In situ monitoring of localized shear stress and fluid flow within developing tissue constructs by Doppler optical coherence tomography
Yali Jia, Pierre O. Bagnaninchi, and Ruikang K. Wang Mechanical stimuli can be introduced to three dimensional (3D) cell cultures by use of perfusion bioreactor. Especially in musculoskeletal tissues, shear stress caused by fluid flow generally increase extra-cellular matrix (ECM) production and cell proliferation. The relationship between the shear s ... [Proc. SPIE Int. Soc. Opt. Eng. 6858, 68580G (2008)] published Wed Feb 6, 2008.