1. Quantification method to objectively evaluate the fibrous structural status of tendons based on polarization-sensitive OCT

    Quantification method to objectively evaluate the fibrous structural status of tendons based on polarization-sensitive OCT

    Histological analysis is widely used to evaluate injured tendons; however, it has the limitation of being semi-quantitative. Hence, we developed a quantification method to objectively evaluate the fibrous structure of tendons, exhibiting the optical property of birefringence, using polarization-sensitive optical coherence tomography (PS-OCT). We used a partial-rupture rat model in which the middle 0.75 cm of the Achilles tendon was cut with a blade. Rats were sacrificed at 2, 4, or 6 weeks after the injury, and PS-OCT and histological analyses were performed. The PS-OCT phase retardation images and score well represented the structural changes of the injured tendon ...

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