1. Passively scanned, single-fiber optical coherence tomography probes for gastrointestinal devices

    Passively scanned, single-fiber optical coherence tomography probes for gastrointestinal devices

    Background/objectives: Optical coherence tomography (OCT) uses low coherence interferometry to obtain depth-resolved tissue reflectivity profiles (M-mode) and transverse beam scanning to create images of two-dimensional tissue morphology (B-mode). Endoscopic OCT imaging probes typically employ proximal or distal mechanical beam scanning mechanisms that increase cost, complexity, and size. Here, we demonstrate in the gastrointestinal (GI) tracts of unsedated human patients, that a passive, single-fiber probe can be used to guide device placement, conduct device-tissue physical contact sensing, and obtain two-dimensional OCT images via M-to-B-mode conversion. Materials and methods: We designed and developed ultrasmall, manually scannable, side- and forward-viewing single fiber-optic ...

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