1. Morphological characteristics of zebrafish's yolk sac for malformation based on orthogonal-polarization-gating optical coherence tomography

    Morphological characteristics of zebrafish's yolk sac for malformation based on orthogonal-polarization-gating optical coherence tomography

    In this study, an automatic algorithm combining an ellipsoid approximation and U-net has been presented for characterization of a zebrafish's yolk sac The polarization-difference-balanced-detection image of zebrafish was obtained based on orthogonal-polarization-gating optical coherence tomography and used to segment the yolk sac region. And ellipsoid can approximate the shape of the three-dimensional yolk sac, and the multiple parameters of volume and the three principal axes (k, l and m) can be used to quantify the yolk sac. In addition, the multiple parameters of two principal axes (l and m) and volume can distinguish the malformation from the normal controlled ...

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