1. Swept-Source Optical Coherence Tomography Detection of Bruch’s Membrane and Choriocapillaris Abnormalities in Sorsby Macular Dystrophy

    Swept-Source Optical Coherence Tomography Detection of Bruch’s Membrane and Choriocapillaris Abnormalities in Sorsby Macular Dystrophy

    Purpose: Swept-source optical coherence tomography angiography (SS-OCTA) was used to analyze Bruch's membrane (BM) and choriocapillaris (CC) abnormalities in undiagnosed family members with Sorsby macular dystrophy (SMD). Methods: In a family with SMD (TIMP3 Tyr191Cys), SS-OCTA imaging was performed using the 6X6mm scan patter and previously validated algorithms to detect abnormalities in BM and the CC, as well as the presence of reticular pseudodrusen (RPD) and macular neovascularization (MNV). Genetic analyses were performed for TIMP3 mutations. Results: Of eight family members, two were previously diagnosed with SMD and six were asymptomatic. SS-OCTA imaging of the 33-year-old proband revealed type ...

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