1. Quantitative optical coherence tomography reveals rod photoreceptor degeneration in early diabetic retinopathy

    Quantitative optical coherence tomography reveals rod photoreceptor degeneration in early diabetic retinopathy

    Purpose: This study is to test the feasibility of optical coherence tomography (OCT) detection of photoreceptor abnormality and to verify the photoreceptor abnormality is rod predominated in early DR . Methods: OCT images were acquired from normal eyes, diabetic eyes with no diabetic retinopathy (NoDR) and mild NPDR. Quantitative features, including thickness measurements quantifying band distances and reflectance intensity features among the external limiting membrane (ELM), inner segment ellipsoid (ISe), interdigitation zone (IZ) and retinal pigment epithelium (RPE) were determined. Comparative OCT analysis of central fovea, parafovea and perifovea were implemented to verify the photoreceptor abnormality is rod predominated in early ...

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