1. Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways

    Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways

    Microscopic evaluation of airway tissue is a long established method in diagnostic and research. Especially the assessment of surgical biopsies is a cornerstone in the diagnostic of airway diseases, but the invasiveness of the preceding excision poses a significant hurdle for a wide application. Furthermore, fixation, dehydration, and staining terminate any biochemical processes and only a static image is created. Therefore, biopsies can not investigate dynamic processes. Airway function, however, is characterized by fast processes such as ciliary beating and mucus transport and in comparison relatively slow processes such as immune cell trafficking. Therefore, techniques that allow imaging of the ...

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