1. Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?

    Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?

    Mitochondria are organelles essential for cellular metabolism that also contribute reflectivity to optical coherence tomography (OCT) via Mie scattering. To find reflectivity sources, we assessed mitochondrial distribution of outer plexiform layer (OPL) using comprehensive volume electron microscopy. Parafoveal retina of a 21-year-old male donor was subject to serial block-face scanning electron microscopy in 5×5×50 nm³ voxels. A convolutional neural network (U-Net) was used to train and generate a deep learning model from manually annotated mitochondria ground truth (Dragonfly 2020.1, Object Research Systems). Using this model, mitochondrial volume and occupancy were calculated as a function of retinal depth ...

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