1. Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity

    Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity

    Purpose To validate retinal capillary density and caliber associations with diabetic retinopathy (DR) severity in different clinical settings. Methods This cross-sectional study assessed retinal capillary density and caliber in the superficial retinal layer of 3-mm OCTA scans centered on the fovea. Images were collected from non-diabetic controls and subjects with mild or referable DR (defined DR worse than mild DR) between February 2016 and December 2019 at secondary and tertiary eye care centers. Vessel Skeleton Density (VSD), a measure of capillary density, and Vessel Diameter Index (VDI), a measure of vascular caliber, were calculated from these images. Discriminatory performance of ...

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