1. Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup

    Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup

    Osteoarthritis (OA) is a degenerative joint disease currently affecting half of all women and one-third of all men aged over 65 and it is predicted to even increase in the next decades. In the variety of causes leading to OA, the first common denominator are changes in the extracellular matrix of the cartilage. In later stages, OA affects the whole joint spreading to higher levels of tissue architecture causing irreversible functional and structural damage. To date, the diagnosis of OA is only formulated in the late stages of the disease. This is also, where most present therapies apply. Since a ...

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