1. Coronary angiography-based shear stress computation to identify high-risk coronary artery plaques: Are we there yet?

    Coronary angiography-based shear stress computation to identify high-risk coronary artery plaques: Are we there yet?

    In the last number of years there has been increasing interest in identifying coronary artery plaques likely to destabilize and cause a future major adverse cardiac event (MACE), with the ultimate goal to inform, and possibly enable, preemptive intervention strategies to prevent that individual plaque's adverse natural history. Intravascular imaging with intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the most precise and accurate methods to characterize the plaque, the arterial wall, and the blood flow patterns surrounding the plaque area. These methods have been the basis for computational fluid dynamics (CFD) calculations of local endothelial or wall ...

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