1. Improved accuracy of tissue glucose measurement using low magnification optical coherence tomography

    Improved accuracy of tissue glucose measurement using low magnification optical coherence tomography

    Optical coherence tomography (OCT) has a comparatively high spatial resolution among tomographic bioimaging techniques and is less affected by changes in physiological conditions such as temperature, blood pressure, and osmolytes in the tissue. OCT detects changes in the refractive index of tissues, which is a function of the tissue glucose concentration (TGC). OCT signal intensity generally decreases with tissue depth, and its slope is expected to show a negative correlation with TGC in the interstitial fluid, reflecting blood glucose concentration (BGC). The currently applied OCT system for measuring TGC does not satisfy the accuracy for clinical demand, mainly because of ...

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