1. Coronary imaging of cardiac allograft vasculopathy predicts current and future deterioration of left ventricular function in patients with orthotopic heart transplantation

    Coronary imaging of cardiac allograft vasculopathy predicts current and future deterioration of left ventricular function in patients with orthotopic heart transplantation

    Background Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT) improve sensitivity of cardiac allograft vasculopathy (CAV) detection compared to invasive coronary angiography (ICA), but their ability to predict clinical events is unknown. We determined whether severe CAV detected with ICA, IVUS or OCT correlates with graft function. Methods Comparison of specific vessel parameters between IVUS and OCT on 20 patients attending for angiography 12–24 months post-orthotopic heart transplant. Serial left ventricular ejection fraction (EF) was recorded prospectively. Results Analyzing 55 coronary arteries, OCT and IVUS correlated well for vessel CAV characteristics. A mean intimal thickness (MIT) OCT >0.25mm ...

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