1. OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

    OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

    Purpose To assess the relationship between best corrected visual acuity (BCVA) and central subfield optical coherence tomography (OCT) features in noninfectious uveitis (NIU)-related macular edema (ME). Design Clinical cohort study from post hoc analysis of two phase 3 clinical trials’ data. Methods Correlation and longitudinal treatment analyses were performed. Of 198 patients with NIU, 134 received suprachoroidally administered CLS-TA (Clearside Biomedical, Inc. proprietary formulation of a triamcinolone acetonide injectable suspension) and 64 received sham, with 12.9% and 72% respectively receiving rescue therapy. Results At baseline, mean BCVA progressively worsened with each ordinal drop in ellipsoid zone (EZ) integrity ...

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