1. Intravascular imaging and histological correlates of medial and intimal calcification in peripheral artery disease

    Intravascular imaging and histological correlates of medial and intimal calcification in peripheral artery disease

    Background: In peripheral artery disease, two different types of calcification are frequently observed, i.e., medial and intimal calcification. Aims: The aim of this study was to determine the ability of intravascular ultrasound (IVUS) imaging and optical frequency domain imaging (OFDI) to detect medial and intimal calcification in human peripheral arteries. Methods: We performed ex vivo intravascular imaging of cadaveric human peripheral arteries with calcifications. IVUS and OFDI images were co-registered with histology. A total of 12 legs from nine patients were examined, and 438 cross-sectional images were co-registered with histology. Results: OFDI could detect 183 of 231 intimal calcifications ...

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