1. Combined Reflection Confocal Microscopy and Optical Coherence Tomography Imaging of Esophageal Biopsy

    Reflection confocal microscopy (RCM) and optical coherence tomography (OCT) are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for histopathologic diagnosis. We have developed a combined RCM and OCT system to compare the accuracy of these imaging techniques for diagnosing esophageal pathology and to evaluate the potential utility of merging the two modalities into a single imaging system. Clinical study was conducted on 32 human esophageal biopsy samples from 23 patients with various histories. Esophageal mucosa was differentiated from gastric mucosa, Barrett's esophagus with intestinal metaplasia was distinguished from ...
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