1. Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography

    Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography

    Background and objectives: Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this study is to utilize optical coherence angiography for vasculature characterization inside and surrounding brain tumors in a murine xenograft brain tumor model. Features included in our analysis include fractional blood volume, vessel tortuosity, diameter, orientation, and directionality. Study design/materials and methods: In this study, five tumorous mice models at 4 weeks of age were imaged. Human glioblastoma cells were injected into the brain and allowed to grow for 4 weeks and then ...

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