1. Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation

    Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation

    Background: It is clinically recognized that collateral vessels can form after retinal vein occlusion (RVO) in some cases and these vessels can lead to spontaneous recovery of the pathological condition. In recent years, optical coherence tomography angiography (OCTA) has become a decisive clinical instrument. Unlike previous angiography tests, OCTA enables the non-invasive visualization of fundus vasculature without the need for administration of a contrast agent. However, it remains to be determined if OCTA depicts the 'true' histological status as several studies have reported artifacts in OCTA imaging. Methods: We generated a laser-induced mouse RVO model, and evaluated the subsequent formation ...

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