1. Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws

    Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws

    Objective To understand the problems involved in using global OCT measures for detecting progression in early glaucoma. Subjects/Methods Eyes from 76 patients and 28 healthy controls (HC) had a least two OCT scans at least 1 year apart. To determine the 95% confidence intervals (CI), 151 eyes (49 HC and 102 patients) had at least two scans within 6 months. All eyes had 24-2 mean deviation ≥-6dB. The average (global) thicknesses of the circumpapillary retinal nerve fibre layer (cRNFL), G ONH , and of the retinal ganglion cell layer plus inner plexiform layer (RGCLP), G mac , were calculated. Using quantile ...

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