1. Optical Coherence Tomography for Quantifying Human Cutaneous Chronic Graft-versus-Host Disease: OCT for cGvHD

    Optical Coherence Tomography for Quantifying Human Cutaneous Chronic Graft-versus-Host Disease: OCT for cGvHD

    Chronic graft versus host disease (cGvHD) is the most common cause of non-relapse mortality after allogeneic hematopoietic cell transplant (alloHCT). Cutaneous cGvHD is characterized by thickening of the skin and connective tissues resulting in discomfort and limitations in mobility. Current assessments of these skin lesions are based on physical examination of their thickening, pinchability, and movability. Optical coherence tomography (OCT) is a non-invasive, high-resolution technique using near infra-red light to interrogate tissues and image the microstructure without the use of contrast agents. We determined the applicability of OCT to human cutaneous cGvHD. Seven patients with varying degrees of cutaneous GvHD ...

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