1. Effects of lipid composition on photothermal optical coherence tomography signals

    Effects of lipid composition on photothermal optical coherence tomography signals

    Significance: Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. Aim: We take the first step in understanding the relation between PT-OCT signals and the endogenous tissue composition by considering the interplay between the opto-thermo-physical properties of tissue as a function of its lipid composition and the ensuing effects on the PT-OCT signals. Approach: Multiparameter theoretical estimates for PT-OCT signal as a function of composition in a two-component lipid–water model are derived and discussed. Experimental data from ...

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