1. Laser scanning reflection-matrix microscopy sees inside intact mouse skull

    Laser scanning reflection-matrix microscopy sees inside intact mouse skull

    Visualizing tissues and neurons inside an animal's skull has long been a challenge for biophotonics techniques, thanks to the skull's thickness and the complex structures inside. Approaches to this problem have included the use of endoscopic platforms in brain imaging, two-photon and three-photon microscopy of small animals, and for surgical purposes the creation of a transparent window in the skull itself. A team at the Institute for Basic Science ( IBS ) in Daejeon, South Korea, has now developed a new approach to tackling the optical aberrations involved in imaging through an intact skull, and tested the system on a ...

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