1. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

    Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

    Introduction: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma that reduces airway smooth muscle (ASM) by radiofrequent energy. No diagnostic method is currently available to assess ASM, other than invasive, focal airway biopsies. Bronchoscopic standard optical coherence tomography (OCT) generates high resolution images of the airways. Polarization sensitive OCT (PS-OCT) provides tissue-specific contrast that might enable ASM detection and quantification. Aim: Use novel PS-OCT to detect ASM and determine changes in ASM before and after BT in severe asthma. Methods: Bronchoscopic PS-OCT was performed from distal to proximal airways in a severe asthma patient before and after BT ...

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