1. Inter- and Intra-Observer Variability in Measurements of Airways Using Optical Coherence Tomography (OCT).

    Purpose: To devise a protocol for the measurement of airways using optical coherence tomography (OCT) with acceptable inter− and intra−observer variability. Methods: 59 subjects from the British Columbia Lung Health Cohort who underwent OCT imaging were studied. OCT images, acquired at the time of bronchoscopy were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis software on 5 consecutive frames when the probe was located in an airway with the same diameter as the probe (1.5mm). The airway lumen and wall areas were measured using the circular ...

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