Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography
Optical imaging for early disease diagnosis, especially cancer, has created significant interest. Label-free methods have gained attention in this regard. The light–matter interaction means that the combination of more than one optical modality for imaging can lead to enhanced specificity and sensitivity. Here we describe efforts using inelastic scattering (Raman) analysis for molecular fingerprinting of tissue combined with morphological information obtained from optical coherence tomography (OCT). This chapter focuses on innovations in these systems that allow us to co-register images at depth simultaneously for both these imaging modes and potential applications for disease diagnosis.