1. Ex-vivo molecular imaging with Upconversion Nanoparticles (UCNPs) using Photo Thermal Optical Coherence Tomography (PTOCT)

    Ex-vivo molecular imaging with Upconversion Nanoparticles (UCNPs) using Photo Thermal Optical Coherence Tomography (PTOCT)

    We demonstrate the photothermal optical coherence tomography (PTOCT) system, with upconversion nanoparticles (UCNPs) as a molecular probe. We synthesize hydrophilic, biocompatible upconversion nanoparticles (UCNPs) using hydrothermal synthesis. We developed the PTOCT system along with the signal processing tool and applied this technique on animal tissue phantom for targeted imaging. The ‘lock-in detection’ of the amplitude modulated photothermal beam (980 nm), which used to excite the UCNPs was the backbone of the signal processing algorithm. The signal processing was further established in different aspects. As an application part, the diffusion dynamics of the UCNPs was performed inside the tissue to study ...

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