1. Visualizing and quantifying cutaneous microvascular reactivity in humans using optical coherence tomography: Impaired dilator function in diabetes

    Visualizing and quantifying cutaneous microvascular reactivity in humans using optical coherence tomography: Impaired dilator function in diabetes

    The pathophysiology and timecourse of impairment in cutaneous microcirculatory function and structure remain poorly understood in diabetics, partly due to the lack of investigational tools capable of directly imaging and quantifying the microvasculature in vivo. We applied a new optical coherence tomography (OCT) technique, at rest and during reactive hyperemia (RH), to assess the skin microvasculature in diabetic people with foot ulcers (DFU, n=13), diabetics without ulcers (DNU, n=9) and matched healthy controls (CON, n=13). OCT images were obtained from the dorsal part of the foot, at rest and 30 seconds after deflation following 5 minutes of ...

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