1. Morphology and physiology together: Is optical coherence tomography the one-stop-shop of invasive cardiology?

    Morphology and physiology together: Is optical coherence tomography the one-stop-shop of invasive cardiology?

    In 1974 Lance Gould demonstrated that maximal coronary flow was progressively reduced by applying external constrictors in animal models [1] and physiology became the gold standard to assess the severity of coronary artery disease. Fractional flow reserve (FFR), measured with invasive intracoronary pressure measurements, proved to obtain the same goal and became the accepted method to study intermediate coronary lesions (European Society of Cardiology Class I and American College/American Heart Association Class IIa, both with Level of Evidence A). The results of the randomized FFR trials supporting this strong recommendation gained more interest in the past few months based ...

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