1. Optical Coherence Tomography Detects Retinal Changes in Hereditary Cerebral Amyloid Angiopathy

    Optical Coherence Tomography Detects Retinal Changes in Hereditary Cerebral Amyloid Angiopathy

    Background Investigating mutation carriers with Dutch‐type hereditary Cerebral Amyloid Angiopathy (D‐CAA), offers the possibility to identify markers in pre‐ and symptomatic stages of CAA. Optical Coherence Tomography (OCT) has shown potential to detect retinal changes in several neurodegenerative diseases. We performed an exploratory study on the thickness of retinal layers as possible (early) biomarker in D‐CAA mutation carriers. Methods D‐CAA mutation carriers (n=8 presymptomatic, n=13 symptomatic, median age 50 years) and (n=9, median age 53 years) controls were scanned using Spectral Domain OCT (SD‐OCT). Symptomatic mutation carriers were defined as having a ...

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