Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery

Entities Mentioned

• Valery V. Tuchin
• Russian Academy of Sciences
• Saratov State University

1. Kinetics, biodistribution, and histological studies were performed to evaluate the particle-size effects on the distribution of 15 nm and 50 nm PEG-coated colloidal gold (CG) particles and 160 nm silica/gold nanoshells (NSs) in rats and rabbits. The above nanoparticles (NPs) were used as a model because of their importance for current biomedical applications such as photothermal therapy, optical coherence tomography, and resonance-scattering imaging. The dynamics of NPs circulation in vivo was evaluated after intravenous administration of 15 nm CG NPs to rabbit, and the maximal concentrations of gold were observed 15-30 min after injection. Rats were injected in the tail ... (Read Full Article)

   Bookmark or Share this article

   
   

   Related Articles

   • Assessing molecular diffusion in tissues using optical coherence tomography
   • also written by Valery V. Tuchin
   • Optical coherence tomography in estimating molecular diffusion of drugs and analytes in ocular tissues
   • also written by Valery V. Tuchin
   • Optimization of Fizeau-based optical coherence tomography with a reference Michelson interferometer
   • also mentions Russian Academy of Sciences
   • Concentration effect on the diffusion of glucose in ocular tissues
   • also written by Valery V. Tuchin
   • Functional imaging and assessment of the glucose diffusion rate in epithelial tissues in optical coherence tomography
   • also written by Valery V. Tuchin

   • Enhanced OCT imaging of embryonic tissue with optical clearing
   • also written by Valery V. Tuchin
   • Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a = 9.3-µm CO2 laser at ablative irradiation intensities with PS-OCT
   • also published in www3.interscience.wiley.com
   • In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach
   • also published in www3.interscience.wiley.com
   • Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy
   • also written by Valery V. Tuchin
   • Principles of Light-Skin Interactions (Book Chapter)
   • also written by Valery V. Tuchin

Login to comment.