1. All Articles

    22681-22704 of 25271 « 1 2 ... 943 944 945 946 947 948 949 ... 1051 1052 1053 »
    1. The role of OCT in glaucoma management

      Clinical examination of the optic nerve and achromatic automated perimetry is the gold standard for the management of glaucoma. However, there is an increasing need for an objective evaluation of the optic nerve structure, particularly for preperimetric glaucoma. Optical coherence tomography (OCT) is a noninvasive tool that measures retinal nerve fiber layer (RNFL) thickness based on its optical properties. Computer image processing algorithms estimate NFL thickness from circumpapillary OCT images that are acquired in cylindrical sections surrounding the optic disc. Average values of NFL thickness can be calculated in the four quadrants or the 12 o’clock position sectors around ...
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    2. High-speed, high-resolution Fourier-domain optical coherence tomography system for retinal imaging in the 1060 nm wavelength region

      A high-speed (47,000 A-scans/s), ultrahigh axial resolution Fourier domain optical coherence tomography (OCT) system for retinal imaging at ~1060 nm, based on a 1024 pixel linear array, 47 kHz readout rate InGaAs camera is presented. When interfaced with a custom superluminescent diode ... [Opt. Lett. 33, 2479-2481 (2008)]
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    3. Detection and treatment of vulnerable plaque

      Advances in the understanding of the role of vulnerable plaque coupled with novel diagnostic and therapeutic approaches create a unique opportunity for cardiovascular events prevention due to rupture of vulnerable plaques. Currently, non-invasive methods do not have enough resolution to identify vulnerable plaques, on the other hand, some invasive methods can define the morphological and anatomic characteristics of vulnerable plaques. These invasive methods include intravascular ultrasound and three dimensional intravascular ultrasound, virtual histology, optical coherence tomography, intravascular magnetic resonance and intracoronary angioscopy. Atherosclerotic plaques causing symptoms require local treatment but the systemic nature of the atherosclerotic process requires global therapeutic ...
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    4. Evaluation of macular abnormalities in Stargardt’s disease using optical coherence tomography and scanning laser ophthalmoscope microperimetry

      Abstract Background  The purpose of this study is to evaluate the diagnostic value of optical coherence tomography (Stratus OCT) and scanning laser ophthalmoscope (SLO) microperimetry in patients with Stargardt’s disease (STGD), and the correlation between macular morphology and visual function in these patients. Methods  Twenty-two patients with STGD (mean age 44 years, range 11 to 71 years) and 20 age-matched healthy control subjects were included in the study. OCT imaging was performed using six radial line scans manually centered on the fovea. SLO microperimetry was used to assess central scotoma and fixation behavior in patients with STGD. Results  Mean ...
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    5. Photon-counting optical coherence-domain reflectometry using superconducting single-photon detectors

      Photon-counting optical coherence-domain reflectometry using superconducting single-photon detectors

      We consider the use of single-photon counting detectors in coherence-domain imaging. Detectors operated in this mode exhibit reduced noise, which leads to increased sensitivity for weak light sources and weakly reflecting samples. In particular, we experimentally demonstrate the possibility of ... [Opt. Express 16, 18118-18130 (2008)]

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    6. Turnkey Devices Incorporate SLED Technology

      Performing in laboratory applications, Exalos’ EBS4000-0000 and EBS8000-0000 turnkey devices with touchscreens enable the use of superluminescent light emitting diode (SLED) technology. The EBS4000-0000 can utilize up to 4 different SLEDs, and the EBS8000-0000 can utilize up to 8 ones with availability as single- or multiple-port optical outputs. The SLEDs offer wavelengths from 650 nm to 1,600 nm and output powers from 1 mW to 25 mW, depending on wavelength. Applications include fiber optic sensing, optical coherence tomography, and optical metrology.
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      Mentions: Exalos
    7. Preoperative optical coherence tomography can predict surgical, acuity outcomes

      Osaka, Japan—Patients with high myopia, macular holes, and no retinal detachment have better visual outcomes compared with patients with high myopia, a macular hole, and a localized retinal detachment with surrounding retinoschisis and compared with patients with high myopia with a macular hole and a retinal detachment within the area of posterior staphyloma and no retinoschisis. This assessement is according to Yasushi Ikuno, MD, associate professor, Department of Ophthalmology, Osaka University Medical School, Osaka, Japan. Macular holes, according to Dr. Ikuno, are a major complication in high myopia; vitrectomy with peeling of the internal limiting membrane peeling and gas ...
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    8. PhD Studentship in Optical Coherence Tomography and Magnetic Resonance Imaging

      Nottingham Trent University School of Science and Technology English Heritage. An exciting new collaborative research project between Nottingham Trent University and the English Heritage is recruiting a PhD student to work on the application of Optical Coherence Tomography and Magnetic Resonance Imaging to the conservation of prehistoric rock art monuments. The studentship offers a stipend of £14,440 (tax free) per annum for three years and Home/EU student fees. A first class or upper second class Honours degree (or equivalent) in a physical science discipline is required. Detailed information can be found on http://www.ntu.ac.uk/research ...
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    9. Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System

      Tomophase to Exhibit First In-vivo Cross-sectional Images of Pulmonary Stenting Using Proprietary OCT System
      Results to be displayed at CHEST meeting in October BURLINGTON, Mass., Oct. 21 /PRNewswire/ -- Tomophase Corporation announced today that it will display the first in-vivo cross-sectional images of implanted pulmonary stents using their proprietary optical coherence tomography (OCT) system at the CHEST meeting in Philadelphia, Oct. 27th through Oct. 29th. The images were captured using the Tomophase OCT System as part of an ongoing research collaboration with Dr. Armin Ernst, Director of Interve
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    10. Towards automated classification of clinical optical coherence tomography data of dense tissues

      The native contrast of optical coherence tomography (OCT) data in dense tissues can pose a challenge for clinical decision making. Automated data evaluation is one way of enhancing the clinical utility of measurements. Methods for extracting information from structural OCT data are appraised here. A-scan analysis allows characterization of layer thickness and scattering parameters, whereas image analysis renders itself to segmentation, texture and speckle analysis. All fully automated approaches combine pre-processing, feature registration, data reduction, and classification. Pre-processing requires de-noising, feature recognition, normalization and refining. In the current literature, image exclusion criteria, initial parameters, or manual input are common requirements ...
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    11. Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes

      Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes
      In frequency-domain optical tomography (FDOT) the quality of the reconstruction result is affected by the choice of the source-modulation frequency. In general the accuracy of the reconstructed image should improve as the source-modulation frequency increases. However, this is only true for noise-free data. Experimental data is typically corrupted by noise and the accuracy is compromised. Assuming the validity of the widely used shot noise model, one can show that the signal-to-noise ratio (SNR) of the amplitude signal decreases with increasing frequency, whereas the SNR of the phase shift reaches peak values in the range between 400 MHz and 800 MHz ...
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    12. Method and an apparatus for shape measurement, and a frequency comb light generator

      A method and an apparatus for shape measurement that is able to observe the deep portion under a skin with high spatial resolution by using a frequency COMB light generator is provided. A frequency COMB light generator for generating multiple frequency COMBs with variable frequency pitch at high operation stability is provided.This apparatus for shape measurement comprises a frequency COMB light generator and an optical interferometer for measuring the distance. The frequency COMB light generator includes a laser light source 11, an optical resonator 13, a COMB pitch regulator 14 and an output port OUT. The optical resonator 13 ...
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    13. Confocal microscope apparatus

      A confocal microscope apparatus capable of rapidly obtaining a tomographic image using OCT measuring. The confocal microscope apparatus for obtaining a tomographic image of a measuring object includes a light modulating section that modulates the frequency of the reference light. The light modulating section includes: a diffraction grating element for dispersing the reference light; a collimator lens for collimating the reference light dispersed by the diffraction grating element; and a reflection mirror for reflecting the reference light transmitted through the collimator lens back to the collimator lens and inputting to the diffraction grating element. The reflection mirror is pivoted on ...
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    14. Control system and apparatus for use with laser excitation and ionization

      A control system and apparatus for use with laser ionization is provided. In another aspect of the present invention, the apparatus includes a laser, pulse shaper, detection device and control system. A further aspect of the present invention employs a femtosecond laser and a mass spectrometer in yet other aspects of the present invention, the control system and apparatus are used in MALDI, chemical bond cleaving, protein sequencing, photodynamic therapy, optical coherence tomography and optical communications processes.
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    15. Eye examination device by means of tomography with a sighting device

      A sighting device is provided for an examination of the eye, including at least one moving target with a programmable form and trajectory, the target being displayed on a visualisation unit, such as an appropriate screen and visible from both eyes during the examination. An in-vivo tomographical eye examination system is also provided, including: a Michelson interferometer, generating a full-field OCT image, adaptable optical apparatus, arranged between the interferometer and an eye for examination, achieving the correction of the wavefronts coming from the eye and also the wavefronts going to the eye, detection apparatus, arranged after the interferometer, permitting the ...
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    16. ODESSA Trial Looks Inside Drug-Eluting Stents With Optical Coherence Tomography (OCT)

      ODESSA Trial Looks Inside Drug-Eluting Stents With Optical Coherence Tomography (OCT)
      October 20, 2008 / Washington, DC -- A new imaging technology, Optical Coherence Tomography (OCT) popped up in a number of presentations and evening symposia at this year's Transcatheter Cardiovascular Therapeutics meeting (TCT 2008). OCT is very new: one of the two currently available systems was first used in humans only five months ago. OCT image from ODESSA Trial, showing covered and uncovered struts of a drug-eluting stent OCT is a catheter-based system which provides a high resolution image of the inner artery surfaces (10 microns) and can easily show if stents have been covered by the body's endothelial cells ...
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    17. Effects of axial, transverse, and oblique sample motion in FD OCT in systems with global or rolling shutter line detector

      This study deals with effects on the interference signal caused by axial, transverse, and oblique motion in spectrometer-based Fourier-domain optical coherence tomography (FD OCT). Two different systems are compared--one with a global shutter line detector and the other with a rolling shutter. We ... [J. Opt. Soc. Am. A 25, 2791-2802 (2008)]
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    18. Search for the perfect tear continues

      Search for the perfect tear continues
      Artificial tear products have a lot of room for improvement, according to new research using advanced imaging techniques. That conclusion stems from findings that the major components of artificial tear products help to formulate a healthy tear film that protects the ocular surface for less than 20 minutes after application. Researchers at the Bascom Palmer Eye Institute, University of Miami, Miami, used serial images from optical coherence tomography (OCT) to demonstrate that major tear preparations, including isotonic sodium chloride solution, increased tear film thickness (TFT) and other variables for at least five minutes after installation. The study, published in the ...
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    19. Keck School researcher David Huang hopes to improve diagnosis of the degenerative eye disease

      Media-Newswire.com) - David Huang, holder of the Charles C. Manger III Chair in Corneal Laser Surgery at the Keck School of Medicine of USC, is the principal investigator of a new $8.9 million grant from the National Institutes of Health to study glaucoma, a leading cause of blindness in the United States. The five-year grant will target the diagnosis and monitoring of glaucoma, a common, chronic degenerative eye disease that does not always present with initial symptoms and is often diagnosed in later stages when vision loss is irreversible. “We hope to improve the diagnosis of glaucoma so people ...
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    20. Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in the Imaging of Anterior Segment Tumors

      Purpose To evaluate the utility of anterior segment optical coherence tomography (OCT) in the imaging of anterior segment tumors and compare the images to ultrasound biomicroscopy (UBM). Design Prospective observational case series. Methods Eighteen eyes of 18 patients with anterior segment tumors were evaluated at Princess Margaret Hospital. The evaluation included clinical examination, clinical photography, anterior segment OCT, and UBM. Comparison of images obtained by both methods was done. Results Anterior segment OCT imaged small hypopigmented tumors with complete penetration. Cysts were incompletely imaged behind the iris pigment epithelium. Highly pigmented tumors, large tumors, and ciliary body tumors were incompletely ...
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    21. Imaging of actinic porokeratosis by optical coherence tomography (OCT)

      Imaging of actinic porokeratosis by optical coherence tomography (OCT)
      Disseminated superficial actinic porokeratosis (DSAP) is a rare, genetically heterogeneous skin disorder. We report a case of a 73-year-old female patient who was diagnosed with DSAP by optical coherence tomography (OCT) and histology. During the last 4 years prior to diagnosis, she had developed numerous (pre)malignant lesions of the skin of the lower legs including actinic keratoses, squamous cell carcinomas and Bowen’s disease. DSAP lesions and actinic keratoses were resistant to topical treatment with imiquimod and retinoids, but improved with photodynamic therapy (PDT).
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    22. Novel neointimal formation over sirolimus-eluting stents identified by coronary angioscopy and optical coherence tomography

      Novel neointimal formation over sirolimus-eluting stents identified by coronary angioscopy and optical coherence tomography
      eointimal proliferation after sirolimus-eluting stent (SES) implantation is generally inhibited by the pharmacological effects of sirolimus in comparison to bare metal stent (BMS). Neointimal hyperplasia after BMS implantation is mainly composed of vascular smooth muscle cells, and is usually observed as a white mass by angioscopy and as a layer of uniform signal intensity without attenuation on optical coherence tomography (OCT). In this case, angioscopic color of the neointima covering the SES was obviously yellow and OCT signal patterns of the neointima showed rapid attenuation similar to lipid tissues in atherosclerotic lesions. These findings suggest that neointima within the SES ...
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    23. Visual system involvement in patients with Friedreich's ataxia

      Optic neuropathy is common in mitochondrial disorders, but poorly characterized in Friedreich's ataxia (FRDA), a recessive condition caused by lack of the mitochondrial protein frataxin. We investigated 26 molecularly confirmed FRDA patients by studying both anterior and posterior sections of the visual pathway using a new, integrated approach. This included visual field testing and optical coherence tomography (OCT), pattern visual evoked potentials (P-VEPs) and diffusion-weighted imaging. The latter was used to study optic radiation by calculating water apparent diffusion coefficients (ADC). All patients suffered optic nerve involvement with their disorder. Different patterns of visual field defects were observed and ...
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