1. All Articles

    73-96 of 27114 « 1 2 3 4 5 6 7 ... 1128 1129 1130 »
    1. Treatment of Periodontal Disease in Systemic Lupus Erythematosus

      Treatment of Periodontal Disease in Systemic Lupus Erythematosus

      Many studies have conducted to evaluate the relationship of systemic inflammatory diseases with periodontal disease. Previous evaluations suggest that there is no significant association between patients with Systemic lupus erythematosus (SLE) and Periodontitis (PD). However, some of the studies have shown relevancy between these two inflammatory diseases and have suggested to explore more for further knowledge. The aim of the study is to establish and investigate a relationship between SLE and PD. The study which will take place in two centers and will recruit 30 patients which will enter a pilot randomized controlled trial. Individuals enrolled into the study will ...

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    2. Laser swept source with controlled mode locking for OCT medical imaging

      Laser swept source with controlled mode locking for OCT medical imaging

      An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. Many high-speed wavelength swept laser sources emit pulses synchronized with the round trip time of the cavity as part of a nonlinear optical frequency red shifting process. Stable pulsation is associated with smooth tuning and low relative intensity noise. Addition of mode-locking methods to this class of lasers can control and stabilize these lasers ...

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    3. Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study

      Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study

      Aims The CLIMA study, on the relationship between c oronary p l aque morphology of the left anter i or descending artery and twelve m onths clinic a l outcome, was designed to explore the predictive value of multiple high-risk plaque features in the same coronary lesion [minimum lumen area (MLA), fibrous cap thickness (FCT), lipid arc circumferential extension, and presence of optical coherence tomography (OCT)-defined macrophages] as detected by OCT. Composite of cardiac death and target segment myocardial infarction was the primary clinical endpoint. Methods and results From January 2013 to December 2016, 1003 patients undergoing OCT evaluation ...

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    4. Measurement of Oral Epithelial Thickness by Optical Coherence Tomography

      Measurement of Oral Epithelial Thickness by Optical Coherence Tomography

      Optical coherence tomography (OCT) is a real-time, in-situ, non-invasive imaging device that is able to perform a cross-sectional evaluation of tissue microstructure based on the specific intensity of back-scattered and reflected light. The aim of the present study was to define normal values of epithelial thickness within the oral cavity. OCT measurements of epithelial thickness were performed in 28 healthy patients at six different locations within the oral cavity. Image analysis was performed using Image J 1.52 software. The healthy epithelium has a mean thickness of 335.59 ± 150.73 µm. According to its location within the oral cavity ...

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    5. Computational Methods to Quantify Human Lens Shape and Optical Properties Using Laser Ray Tracing and Optical Coherence Tomography (Thesis)

      Computational Methods to Quantify Human Lens Shape and Optical Properties Using Laser Ray Tracing and Optical Coherence Tomography (Thesis)

      Vision is worsening on a global scale. Myopia, a visual condition where distant objects appear blurry, is increasing in prevalence at an alarming rate. This condition typically starts during childhood and progressively worsens, potentially leading to more severe visual conditions if left unchecked. Currently, the best treatment method to slow myopic progression is heavily debated as the etiology of myopia is not fully understood. The development of effective long-term solutions require a better understanding of how vision changes with age. The cornea and lens, the length of the human eye, and the surrounding ocular media dictate visual quality. Extensive studies ...

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    6. Methods and systems for combined morphological and angiographic analyses of retinal features

      Methods and systems for combined morphological and angiographic analyses of retinal features

      Methods and systems in ophthalmic imaging are presented that increase the sensitivity of automated diagnoses by the use of a combination of both functional and structural information derived from a variety of ophthalmic imaging modalities. An example method to analyze image data of an eye of a patient includes processing a first image dataset to obtain one or more functional metrics; processing a second image dataset to obtain one or more structural metrics; comparing the one or more structural metrics to the one or more functional metrics; and processing the results of said comparison to derive the probability of a ...

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    7. OCT motion contrast data analysis apparatus and OCT motion contrast data analysis method

      OCT motion contrast data analysis apparatus and OCT motion contrast data analysis method

      An OCT motion contrast data analysis apparatus includes: a processor; and memory storing computer readable instructions, when executed by the processor, causing the OCT motion contrast data analysis apparatus to execute: acquiring OCT motion contrast data of a subject by an optical coherence tomography; and performing an analysis process with respect to the OCT motion contrast data based on an analysis chart set on image data different from the OCT motion contrast data.

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      Mentions: Nidek
    8. Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening

      Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening

      Optical Coherence Tomography (OCT) imaging plays an important role in glaucoma diagnosis in clinical practice. Early detection and timely treatment can prevent glaucoma patients from permanent vision loss. However, only a dearth of automated methods has been developed based on OCT images for glaucoma study. In this paper, we present a novel framework to effectively classify glaucoma OCT images from normal ones. A semi-supervised learning strategy with smoothness assumption is applied for surrogate assignment of missing function regression labels. Besides, the proposed multi-task learning network is capable of exploring the structure and function relationship from the OCT image and visual ...

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    9. Optical coherence tomography and cognitive dysfunction in Parkinson disease

      Optical coherence tomography and cognitive dysfunction in Parkinson disease

      Background Parkinson’s disease (PD) is a progressive neurodegenerative disease of aging. Optical coherence tomography (OCT) is a simple noninvasive imaging technique to estimate the retinal nerve fiber layer (RNFL) thickness. The aim of this study is to measure the changes of the RNFL thickness in patients with Parkinson disease in comparison with the control group and to detect the relationship between these changes in RNFL with cognitive functions and physical disability in Parkinson patients. Methods 20 PD patients (40 eyes) and 20 healthy persons (40 eyes) were enrolled according to the defined criteria. The diagnosis of the patient's ...

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    10. A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)

      A Novel Use of Optical Coherence Tomography for the Assessment of Ocular Torsion (Thesis)

      Abnormal ocular torsion is most frequently the result paresis of the fourth cranial nerve. The presence of torsion can be a barrier to fusion, in which case, surgical intervention is required for a patient to have single vision. Clinically, ocular torsion can be measured either subjectively or objectively, the latter traditionally using the relationship between the fovea and the optic disc. However, previous literature has shown inconsistencies between torsion a patient’s perceived subjective torsion, and the amount of anatomical fundus torsion. Therefore, the aim of the current study was to investigate the relationship of subjective and objective ocular torsion ...

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    11. Diagnostic Ability of Macular Vessel Density in the Ganglion Cell–Inner Plexiform Layer on Optical Coherence Tomographic Angiography for Glaucoma

      Diagnostic Ability of Macular Vessel Density in the Ganglion Cell–Inner Plexiform Layer on Optical Coherence Tomographic Angiography for Glaucoma

      Purpose : The purpose of this study was to analyze the macular vessel density layer-by-layer and compare the diagnostic value of each in diagnosing glaucoma. Methods : This was a prospective comparative cross-sectional study, and the setting was glaucoma referral practice. The study participants were patients with primary open-angle glaucoma undergoing treatment with drugs, and age-matched normal controls who visited our clinic for regular eye examinations for refractive errors. All participants were investigated using macular optical coherence tomographic angiography, fundus photography, and 24-2 visual field (VF) testing. Average vessel densities in the retinal nerve fiber–ganglion cell–inner plexiform layer (IPL), retinal ...

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    12. High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band

      High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band

      We present three-dimensional (3-D) high-resolution spectral-domain optical coherence microscopy (SD-OCM) by using a supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at half-maximum) in the 1700-nm spectral band. By using low-coherence interferometry with SC light and a confocal detection scheme, we realized lateral and axial resolutions of 3.4 and 3.8  μm in tissue ( n   =  1.38), respectively. This is, to the best of our knowledge, the highest 3-D spatial resolution reported among those of Fourier-domain optical coherence imaging techniques in the 1700-nm spectral band. In our SD-OCM, to enhance the imaging depth, a full-range method was ...

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    13. Deep Learning Based Fluid Segmentation in Retinal Optical Coherence Tomography Images

      Deep Learning Based Fluid Segmentation in Retinal Optical Coherence Tomography Images

      Macular Edema (ME) is the accumulation of fluid in the macular region of the eye, and it may lead to the distortion of center vision. It often occurs in diabetic retinopathy. It is important to measure fluid accumulation in ME patients for disease monitor. Segmentation of the fluid region in the retinal layer is an essential step for quantitatively analysis. However, manual segmentation is time consuming and also subjective. In this paper, a new deep learning based segmentation method is proposed. The attention mechanism is introduced to automatically locate the fluid region, which can reduce the number of parameters compared ...

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    14. Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels

      Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels

      Tortuous coronary lesions are associated with adverse outcomes after implantation of bare metal or first-generation drug-eluting stents (DESs). We investigated the impact of lesion angle on vessel wall injuries and stent apposition as assessed by optical coherence tomography (OCT) after second- and newer-generation DES implantation. We investigated 95 de novo lesions treated with a single DES (62 platinum-chromium everolimus-eluting stents and 33 bioresorbable-polymer sirolimus-eluting stents). Post-intervention OCT findings were compared between angled lesions (≥ 45°; n = 33) and non-angled lesions (< 45°; n = 62). The 12-month clinical outcomes were also compared between the groups. Cross-sectional OCT analysis revealed that compared to non-angled ...

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    15. Relationship of Posterior Capsular Opacification and Capsular Bend Type Investigation Based on Swept-source Optical Coherence Tomography

      Relationship of Posterior Capsular Opacification and Capsular Bend Type Investigation Based on Swept-source Optical Coherence Tomography

      Purpose : To investigate the relationship between capsular bend type and posterior capsule opacification (PCO) at a three-dimensional (3D) level using high-speed swept-source optical coherence tomography (SS-OCT). Methods : This was a retrospective study. A total of 99 eyes that underwent standard cataract surgery with phacoemulsification 2 years ago were analyzed. Standard SS-OCT radial scanning was performed in all eyes and the obtained photos were used for morphological observations of the capsular bend-IOL complex, the adhesion of posterior capsule to the IOL optic, and the position of the anterior capsulorhexis. Digital retroillumination photographs were taken of the posterior capsule of each eye ...

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    16. OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      Background Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis. Material and methods This immediate ex-vivo study included skin specimens from 103 patients with suspicious skin lesions. In total, 110 lesions were scanned using OCT immediately following surgical resection. Two experienced OCT reviewers assessed these OCT diagnostic parameters blindly at two different intervals based on the parameters of the ...

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    17. RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge

      RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge

      Retinal swelling due to the accumulation of fluid is associated with the most vision-threatening retinal diseases. Optical coherence tomography (OCT) is the current standard of care in assessing the presence and quantity of retinal fluid and image-guided treatment management. Deep learning methods have made their impact across medical imaging, and many retinal OCT analysis methods have been proposed. However, it is currently not clear how successful they are in interpreting the retinal fluid on OCT, which is due to the lack of standardized benchmarks. To address this, we organized a challenge RETOUCH in conjunction with MICCAI 2017, with eight teams ...

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    18. OCT Feasibility Older Hip Fracture

      OCT Feasibility Older Hip Fracture

      Optical coherent tomography (OCT) is a device used to achieve cross-sectional imaging of tissues. It is often used in ophthalmology and also has application in dermatology, cardiology and other specialities. Usually, in adults, a table-top device is used necessitating the transfer of patients to the location of the device. In children a hand held device is used meaning the device can be taken to the patients' location. To facilitate/ help design a future study, this study's aim is to assess the feasibility of achieving retinal imaging in older people who are recovering from hip fracture surgery using a hand ...

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    19. Average Lens Density Quantification With Swept Source OCT Integrated Into the Iolmaster 700: An Optimized and Automatized Version of the Technique for Cataract Grading

      Average Lens Density Quantification With Swept Source OCT Integrated Into the Iolmaster 700: An Optimized and Automatized Version of the Technique for Cataract Grading

      Purpose To assess an upgraded version of our objective cataract grading method based on lens densitometry on Swept-Source Optical Coherence Tomography (SS-OCT) scans provided by the IOLMaster 700. Settings Single centre study at the Rothschild Foundation, Paris, France. Design Prospective cross-sectional study Methods All patients consulting for cataract evaluation and consenting to study participation were included. History of previous ocular surgery, cornea or retina disorders, and ocular dryness were exclusion criteria. The average lens densitometry (ALD) was measured on SS-OCT scans provided by the IOLMaster 700 using our algorithm developed on MATLAB® software. The ocular scatter index (OSI) was measured ...

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    20. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive optics—in particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected apertures, we improved aberration correction. Since these modifications only slightly increase the run time of the correction, we believe this method can become the algorithm of choice for many ...

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    21. Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL in human eyes. From the segmentation, en face images of RNFL thickness and RNFL birefringence were created. The measured birefringence values are consistent with earlier reports.

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