1. All Articles

    73-96 of 25874 « 1 2 3 4 5 6 7 ... 1076 1077 1078 »
    1. Lens anatomy parameters with intraoperative spectral-domain optical coherence tomography in cataractous eyes

      Lens anatomy parameters with intraoperative spectral-domain optical coherence tomography in cataractous eyes

      Purpose: To study correlations of crystalline lens anatomy and position parameters obtained using intraoperative spectral-domain (SD) optical coherence tomography (OCT) in cataract patients. Methods: This retrospective study evaluated biometry data from 600 eyes of 399 cataract patients (mean age: 69±8.4 years) using intraoperative anterior segment SD-OCT during femtosecond laser-assisted cataract surgery. Lens anatomy and position parameters (anterior chamber depth [ACD] – center of the anterior cornea to the anterior lens capsule, lens thickness [LT] – distance between anterior and posterior lens capsules, and lens meridian position [LMP] – distance from center of the anterior cornea to intersection of the anterior and ...

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    2. Elucidation of microstructural changes in leaves during senescence using spectral domain optical coherence tomography

      Elucidation of microstructural changes in leaves during senescence using spectral domain optical coherence tomography

      Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata . Hayata leaves show autumn phenology and change color from green to yellow and finally red. SD-OCT image analysis shows distinctive features among different layers of the leaves; merging of upper epidermis and palisade layers form thicker layers in red leaves compared to green leaves. Moreover, A-scan analysis showed a significant (p < 0.001) decrease in the attenuation coefficient ...

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      Mentions: Wen-Chuan Kuo
    3. Unsupervised feature extraction of anterior chamber OCT images for ordering and classification

      Unsupervised feature extraction of anterior chamber OCT images for ordering and classification

      We propose an image processing method for ordering anterior chamber optical coherence tomography (OCT) images in a fully unsupervised manner. The method consists of three steps: Firstly we preprocess the images (filtering the noise, aligning and normalizing the resolution); secondly, a distance measure between images is computed for every pair of images; thirdly we apply a machine learning algorithm that exploits the distance measure to order the images in a two-dimensional plane. The method is applied to a large (~1000) database of anterior chamber OCT images of healthy subjects and patients with angle-closure and the resulting unsupervised ordering and classification ...

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    4. Detection of laser-induced bulk damage in optical crystals by swept-source optical coherence tomography

      Detection of laser-induced bulk damage in optical crystals by swept-source optical coherence tomography

      An approach to characterize laser-induced bulk damage in optical crystal materials was demonstrated. With a homemade swept-source optical coherence tomography (SS-OCT) system, we obtained three-dimensional images of the bulk damage produced by laser pulses with wavelength of 351 nm, pulse width of 5 ns, beam diameter of 5.5 mm and fluences from 4.56 J/cm 2 to 9.95 J/cm 2 in Potassium Dihydrogen Phosphate (KDP) crystal. Algorithms based on three-dimensional OCT images were specially designed to count and locate bulk damage pinpoints in KDP crystal, obtaining their equivalent diameter distribution and pinpoint density caused by different ...

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    5. Cake formation of bidisperse suspensions in dead-end microfiltration

      Cake formation of bidisperse suspensions in dead-end microfiltration

      The evolution of the cake during dead-end microfiltration of different compositions of bidisperse feeds was investigated using network modeling and three-dimensional (3D) optical coherence tomography (OCT) imaging. The foulant particles were latex of two different sizes (namely, 3 and 5 μm) and the membrane was polycarbonate track-etched with nominal diameter of 2 μm. The results from the network model indicate that (i) the deposition of the smaller particles on the non-porous area was reduced by the presence of larger particles, whereas that of the larger particles was not affected by the concentration of the smaller ones; and (ii) monodisperse small ...

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    6. SLIME: robust, high-speed 3D microvascular mapping

      SLIME: robust, high-speed 3D microvascular mapping

      Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.

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    7. Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System (Thesis)

      Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System (Thesis)

      This paper serves as a detailed overview of the software developed for the Falloposcope endoscope being developed by the Jennifer Barton Optics Tissue Laboratory. The Falloposcope is designed for a screening procedure for early detection of ovarian cancer in the fallopian tubes. The software controls a charge-coupled device (CCD) camera to perform reflectance and fluorescence imaging, which serves to navigate the endoscope to the fallopian tubes and surveil suspicious tissue regions. It also controls a swept source optical coherence tomography (SS-OCT) imaging system to provide high resolution, cross-sectional tomographic images of these tissue regions. CCD imaging is performed using a ...

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    8. Development of Multimodal Optical System Guided by Optical Coherence Tomography (Thesis)

      Development of Multimodal Optical System Guided by Optical Coherence Tomography (Thesis)

      The goal of this dissertation is to develop multimodal light scattering techniques using optical coherence tomography (OCT) to improve clinical diagnosis. OCT is a noninvasive optical imaging technique that utilizes low coherence interferometry to detect reflected and scattered light from a sample to produce depth resolved images. OCT is an emerging technology for a wide range of biomedical applications, with its largest impact in the field of ophthalmology to assess retinal morphology and abnormalities. Due to its excellent axial resolution, OCT has been often jointly used with a variety of other optical techniques in multimodal platforms for enhanced characterization of ...

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      Mentions: Duke University
    9. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO UNILATERAL RETINAL PIGMENT EPITHELIUM DYSGENESIS TREATED WITH INTRAVITREAL BEVACIZUMAB THERAPY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO UNILATERAL RETINAL PIGMENT EPITHELIUM DYSGENESIS TREATED WITH INTRAVITREAL BEVACIZUMAB THERAPY

      Purpose: To document by optical coherence tomography angiography the presence of a choroidal neovascularization ( CNV ) secondary to unilateral retinal pigment epithelium dysgenesis and describe its changes after treatment with intravitreal bevacizumab . Methods: Case report. Results: A 51-year-old woman referred to our ocular oncology service for a possible choroidal osteoma in her left eye was found to have a unilateral retinal pigment epithelium dysgenesis complicated by CNV . Best-corrected visual acuity at baseline was 20/200. A complete ophthalmological evaluation including color fundus photography, fundus autofluorescence , fluorescein angiography , indocyanine green angiography, optical coherence tomography, and optical coherence tomography angiography was performed. The ...

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    10. Optical Coherence Tomography of the Retina in Schizophrenia: Relationships with Visual and Perceptual Function (Thesis)

      Optical Coherence Tomography of the Retina in Schizophrenia: Relationships with Visual and Perceptual Function (Thesis)

      Background: Visual perceptual impairments are well established in schizophrenia, ranging from deficits in basic visual discrimination to abnormalities in higher-level visual integration. Recent research has identified thinning o f retinal layers in individuals with schizophrenia, which may contribute to visual dysfunction. This study utilized optical coherence tomography to examine retinal integrity in individuals with schizophrenia, and investigated the contributions of retinal structure to low- and higher-level visual functions in schizophrenia. Methods: Participants were 12. individuals with schizophrenia-spectrum disorders and 12 age-matched healthy controls. Optical coherence tomography was utilized to obtain measurements for the retinal nerve fiber layer (RNFL), ganglion cell ...

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    11. Automated phase unwrapping in Doppler optical coherence tomography

      Automated phase unwrapping in Doppler optical coherence tomography

      Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. The voxels affected by phase wrapping are corrected according to the determined flow direction adjacent to the vessel walls. We validated this technique in the rodent ...

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    12. Ocular Morphological Changes in Patients with Restless Legs Syndrome Analyzed by Optical Coherence Tomography

      Ocular Morphological Changes in Patients with Restless Legs Syndrome Analyzed by Optical Coherence Tomography

      Background Two leading hypotheses for restless legs syndrome (RLS) pathophysiology are dopaminergic dysfunction and sympathetic overactivity. Ocular changes occur with both dopaminergic and sympathetic pathologies, and thus may provide unique insights into the pathophysiology of RLS. Methods Thirty-five patients with RLS and 35 healthy individuals were enrolled in the study. Peripapillary retinal nerve fiber layer (RNFL), macular, and choroidal thicknesses were measured by optical coherence tomography (OCT). Results There were no statistically significant differences between the two groups regarding RNFL and macular thicknesses. The subfoveal, temporal and nasal choroidal thicknesses were significantly thinner in patients with RLS compared with normal ...

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      Mentions: Emory University
    13. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Optical coherence tomography (OCT) is an emerging technology for in vivo< airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary information to OCT for airway and lung imaging. We demonstrate OCT and RI of respiratory ciliated epithelial function in ex vivo mouse tracheae. We applied RI to measure cellular metabolism ...

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    14. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process ...

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    15. Product Development Engineer Opening at Opticent Health

      Product Development Engineer Opening at Opticent Health

      Opticent, Inc. (Opticent Health – www.opticenthealth.com) , established in 2015, is a fast growing medical device start-up company commercializing visible-light optical coherence tomography (vis-OCT), a novel imaging modality for a variety of applications, including advanced ophthalmic diagnostics. First developed at Northwestern University, Opticent Health’s core technologies have been embraced by leading researchers in clinical and pre-clinical ophthalmic investigations, which has fueled rapid commercial development of vis-OCT products. Opticent Health is located in Evanston IL, part of the greater Chicago metropolitan area. The company’s management team, with guidance from its medical and technical advisory board, is expanding its engineering ...

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    16. Stent malapposition, strut coverage and atherothrombotic prolapse after percutaneous coronary interventions in ST-segment elevation myocardial infarction

      Stent malapposition, strut coverage and atherothrombotic prolapse after percutaneous coronary interventions in ST-segment elevation myocardial infarction

      Aims Stent implantation in ST-segment elevation myocardial infarction (STEMI) patients can be challenging and sometimes associated with immediate and long-term suboptimal results. Stent malapposition and strut uncoverage, predictors of stent thrombosis, are frequently detected in STEMI patients at medium/long-term follow-up. Nevertheless, data at a short follow-up are missing. We aimed to assess the extent of stent malapposition and struts coverage in the subacute phase of STEMI after stent implantation in primary or rescue percutaneous coronary intervention (PCI). Methods STEMI patients undergone primary or rescue PCI and scheduled for a second coronary angiography after 2–7 days were enrolled. During ...

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    17. Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea

      Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea

      We developed a spectral domain optical coherence tomography (SDOCT) fiber optic probe for imaging and sub-nanometer displacement measurements inside the mammalian cochlea. The probe, 140 μm in diameter, can scan laterally up to 400 μm by means of a piezoelectric bender. Two different sampling rates are used, 10 kHz for high-resolution B-scan imaging, and 100 kHz for displacement measurements in order to span the auditory frequency range of gerbil (~50 kHz). Once the cochlear structures are recognized, the scanning range is gradually decreased and ultimately stopped with the probe pointing at the selected angle to measure the simultaneous displacements of ...

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    18. Senior Software Engineer Opening In Medical devices at Westface Medical

      Senior Software Engineer Opening In Medical devices at Westface Medical

      Senior Software Engineer – Medical devices – C/C++ If you are a Senior Software Engineer with medical device and an embedded C/C++ background, please read on! Based in Truckee, with R&D operations in Redwood City CA, we are a Medical Device startup developing opto-electro-mechanical devices for image-guided surgery. We are looking for a great software engineer to support medical device development from early R&D concepts through prototype and full development including pre-clinical testing, clinical evaluations, and regulatory approval. General Summary: Provides software design, development and support leadership in a small cross-functional product development team developing a state-of-the-art image-guided ...

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      Mentions: WestFace Medical
    19. Mechanical Engineer Opening in Medical devices at Westface Medical

      Mechanical Engineer Opening in Medical devices at Westface Medical

      Mechanical Engineer – Medical devices If you are a Mechanical Engineer with a disposables / durables medical device background, please read on! Based in Truckee, with R&D operations in Redwood City CA, we are a Medical Device startup developing opto-electro-mechanical devices for image-guided surgery. We are looking for a great ME to support medical device development from early R&D concepts through prototype and full development including pre-clinical testing, clinical evaluations, and regulatory approval. General Summary: Provides mechanical design, development and support leadership in a small cross-functional product development team developing a state-of-the-art image-guided surgical system. Works with company principals, other ...

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      Mentions: WestFace Medical
    20. OPTICAL COHERENCE TOMOGRAPHY LEAKAGE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      OPTICAL COHERENCE TOMOGRAPHY LEAKAGE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      Purpose: To test optical coherence tomography leakage in the identification and quantification of choroidal neovascularization–related fluid, its change after anti–vascular endothelial growth factor therapy in neovascular age-related macular degeneration eyes and its relation to functional outcome. Methods: Prospective analysis of a cohort of neovascular age-related macular degeneration cases treated with 2.0-mg intravitreal aflibercept. Eyes included were analyzed before, 1-week, and 1-month after one injection. Best-corrected visual acuity was assessed using Early Treatment Diabetic Retinopathy Study method. Optical coherence tomography leakage maps depicting low optical reflectivity (LOR) sites were acquired with OCT Cirrus AngioPlex (Zeiss, Dublin, CA). The ...

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    21. Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy

      Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy

      Purpose To analyze the choroidal thickness (CT) of each type of myopic maculopathy, and to establish an OCT-based classification of myopic maculopathy. Design Retrospective, hospital-based, cross-sectional study. Participants Highly myopic (HM) eyes that were examined by swept-source OCT. Methods The CT was measured at the subfovea and at 3 mm nasal, temporal, superior, and inferior to the fovea. Myopic maculopathy was classified as tessellation, diffuse atrophy, patchy atrophy, and macular atrophy (MA) based on the fundus photographs. Diffuse atrophy was subdivided into peripapillary diffuse choroidal atrophy (PDCA) or macular diffuse choroidal atrophy (MDCA). Main Outcome Measures The CT of each ...

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    22. New low-cost 12 bit, 50 MS/s PCI Express waveform digitizer from AlazarTech

      New low-cost 12 bit, 50 MS/s PCI Express waveform digitizer from AlazarTech

      AlazarTech , a manufacturer of high-performance, low-cost PC Based Instruments, today announced the release of AlazarTech ATS ® 9130, a dual-channel 50 MS/s, 12 bit waveform digitizer based on the single-lane Gen1 PCI Express bus. ATS9130 features two simultaneous analog input channels that can each be sampled at rates up to 50 MS/s with 12 bit vertical resolution. Each channel has 25 MHz of full power analog input bandwidth and up to 8 Megasamples of on-board acquisition memory buffer. With software selectable attenuation, users can achieve an input voltage range of ±40 mV to ±20 V. “ATS9130 is a continuation ...

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    73-96 of 25874 « 1 2 3 4 5 6 7 ... 1076 1077 1078 »
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