1. All Articles

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    1. COMPARISON OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY PARAMETERS BETWEEN CENTRAL RETINAL VEIN OCCLUSION AND NORMAL EYES: Is Primary Angle Closure a Risk Factor for Central Retinal Vein Occlusion?

      COMPARISON OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY PARAMETERS BETWEEN CENTRAL RETINAL VEIN OCCLUSION AND NORMAL EYES: Is Primary Angle Closure a Risk Factor for Central Retinal Vein Occlusion?

      Purpose: To compare anterior segment parameters in patients with central retinal vein occlusion (CRVO) with normal control subjects by anterior segment optical coherence tomography (AS-OCT). Methods: In this coss-sectional case-control study, 42 eyes from 21 patients with unilateral CRVO and 21 eyes from 21 age- and sex-matched healthy control subjects were recruited. Study eyes were divided into three groups: involved eyes of CRVO patients (CRVO eyes), fellow eyes of CRVO patients (fellow eyes), and control eyes. Complete ocular examination and AS-OCT were performed for each eye. The AS-OCT parameters (anterior chamber depth, scleral spur angle, angle opening distance [AOD] at ...

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    2. Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa

      Spectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa

      Purpose To determine the relationship between prelaminar structural changes of the optic nerve head (ONH) and optic nerve waxy pallor in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) and fundus photography. Methods An observational cross-sectional case control study of patients with RP with and without ONH waxy pallor and controls. Subjects underwent clinical examination, fundus photography, and SD-OCT raster imaging of the ONH. Four independent specialists reviewed the images in a masked fashion. Results Fifty-five eyes of 31 subjects with RP and 28 eyes of 14 controls were included. Optic nerve head waxy pallor was seen in 29 ...

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    3. Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      David Huang, MD, PhD, Peterson Professor of Ophthalmology and Professor of Biomedical Engineering at Oregon Health & Science University, has joined the Research to Prevent Blindness (RPB) Scientific Advisory Board. This will enhance the ability of RPB to evaluate imaging and engineering based grant applications. For information on RPB grant program, please see https://www.rpbusa.org/rpb/grants/grants/

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    4. Intraoperative OCT improves ophthalmic surgery

      Intraoperative OCT improves ophthalmic surgery

      The most popular examination method in ophthalmology today is optical coherence tomography (OCT ). Traditionally, OCT examinations have been performed pre- and post-operatively in vitreo-retinal surgery. While this application of the technology has enabled outcomes to be measured and results to be documented, surgeons have not had the ability to incorporate the results to improve surgical treatments. But with considerable advances to OCT—including high-definition OCT (HD OCT), 3D visualization , and adaptive optics —the integration of these methods into the surgical microscope is logical. The technology is now helping ophthalmologists carry out delicate eye surgeries. In today's integrated microscopy systems ...

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    5. Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.

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    6. Quantitative single-mode fiber based PS-OCT with single input polarization state using Mueller matrix

      Quantitative single-mode fiber based PS-OCT with single input polarization state using Mueller matrix

      We present a simple but effective method to quantitatively measure the birefringence of tissue by an all single-mode fiber (SMF) based polarization-sensitive optical coherence tomography (PS-OCT) with single input polarization state. We theoretically verify that our SMF based PS-OCT system can quantify the phase retardance and optic axis orientation after a simple calibration process using a quarter wave plate (QWP). Based on the proposed method, the quantification of the phase retardance and optic axis orientation of a Berek polarization compensator and biological tissues were demonstrated.

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    7. Haag-Streit UK launch the Optovue AngioVue in the UK

      Haag-Streit UK launch the Optovue AngioVue in the UK

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce the launch of the AngioVue OCT Angiography (OCTA) system, in the UK. The AngioVue is the first commercial OCTA system capable of imaging and displaying the function of the ocular microvasculature, through a non-invasive procedure. The innovative system uses a unique dyeless technique to quickly evaluate the functional blood flow of the retina and optic nerve. This method allows the procedure to be performed in everyday clinical practice and unlike fluorescein angiography, can be repeated as often as required, and with no ...

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      Mentions: Optovue Haag-Streit
    8. Optical Coherence Tomography

      Optical Coherence Tomography

      This sounds interesting - a whizzy new camera (seen above, in front of a copy of a Raphael at the National Gallery) can digitally take cross-sections of a painting. Normally, to find out the exact build up of layers in a painting (from ground layer to the tpyes of pigments used), you need to physically take a sample of paint, flip it on its side, and then look at the cross-section under a microscope (as in the colour photo below). But this new camera - developed at Nottingham Trent University - allows a virtual cross-section to be taken, and the results look as ...

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    9. UC Irvine Receives NIH Grant for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings.

      UC Irvine Receives NIH Grant  for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings.

      University of California Irvine Receives a 2015 NIH Grant for $25,263 for Low-Cost Simple Oral cancer Screening Device for Low-Resource Settings. The principal investigator is Petra Wilder-Smith. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer therapy. The ...

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    10. Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography

      Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography

      Boston University Receives a 2015 NIH Grant for $259,490 for Visualizing Cortical Microstructures by Optical Coherence Tomography. The principal investigator is Katehleen Rockland. The program began in 2015 and ends in 2017. Below is a summary of the propose work.

      Area-specific differences in microstructure and cell-type distribution are well-established across cortical regions in the human brain; and specific morphological changes have been identified in different disease conditions, such as cortical thinning or, at a finer level of resolution, changes in specific pyramidal or non-pyramidal cell populations. These data, however, are based on relatively small sample sizes and can be ...

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    11. Adaptive optimization of reference intensity for optical coherence imaging using galvanometric mirror tilting method

      Adaptive optimization of reference intensity for optical coherence imaging using galvanometric mirror tilting method

      Integration time and reference intensity are important factors for achieving high signal-to-noise ratio (SNR) and sensitivity in optical coherence tomography (OCT). In this context, we present an adaptive optimization method of reference intensity for OCT setup. The reference intensity is automatically controlled by tilting a beam position using a Galvanometric scanning mirror system. Before sample scanning, the OCT system acquires two dimensional intensity map with normalized intensity and variables in color spaces using false-color mapping. Then, the system increases or decreases reference intensity following the map data for optimization with a given algorithm. In our experiments, the proposed method successfully ...

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      Mentions: Korea University
    12. Evaluation of retinal nerve fiber layer thickness measured by optical coherence tomography in Moroccan patients with multiple sclerosis

      Evaluation of retinal nerve fiber layer thickness measured by optical coherence tomography in Moroccan patients with multiple sclerosis

      Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal inflammatory infiltrates, demyelinating lesions and axonal injury. The purpose of the study was to evaluate the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in Moroccan patients with MS and to assess the relationship between RNFL thickness and disease duration, Expanded Disability Status Scale (EDSS) score, visual acuity and automated visual field indices. Materials and methods Thirty-one patients with definite MS and thirty-one disease-free controls were enrolled in the study. After neurologic consultation, ophthalmologic examination including visual acuity, automated visual ...

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    13. Changes in Area of Conjunctiva and Tear Meniscus Measured Using Anterior Segment Optical Coherence Tomography after Conjunctivochalasis Surgery

      Changes in Area of Conjunctiva and Tear Meniscus Measured Using Anterior Segment Optical Coherence Tomography after Conjunctivochalasis Surgery

      Purpose To evaluate cross-sectional areas of conjunctiva and tear meniscus of conjunctivochalasis using Fourier-Domain RTVue-100 optical coherence tomography (OCT) before and after conjunctivochalasis surgery. Methods Thirty-one patients (33 eyes) with symptomatic conjunctivochalasis were recruited for this study between June 2013 and April 2014. All patients underwent crescent-shaped conjunctiva resection and amniotic membrane transplantation. Anterior segment OCT (AS-OCT) imaging was performed and tear break-up time was evaluated prior to and 3 months after the conjunctivochalasis surgery. Cross-sectional areas of conjunctiva and tear meniscus of conjunctivochalasis at 7 locations (1 center, 3 nasal and 3 temporal areas) were measured in all patients ...

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    14. A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy

      A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy

      Raman sensing and microscopy are among the most specific optical technologies to identify the chemical compounds of unknown samples, and to enable label-free biomedical imaging. Here we present a method for stimulated Raman scattering spectroscopy and imaging with a time-encoded (TICO) Raman concept. We use continuous wave, rapidly wavelength-swept probe lasers and combine them with a short-duty-cycle actively modulated pump laser. Hence, we achieve high stimulated Raman gain signal levels, while still benefitting from the narrow linewidth and low noise of continuous wave operation. Our all-fibre TICO-Raman setup uses a Fourier domain mode-locked laser source to achieve a unique combination ...

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    15. Technique to measure volumes of key 'Lab on a Chip' components

      Technique to measure volumes of key 'Lab on a Chip' components

      Imagine shrinking tubes and beakers—in fact, most of a clinical chemistry lab—down to the size of a credit card. When engineers figured out how to do that two decades ago, they enabled complex tests to be performed with tiny "lab on a chip" technology. But until now, there has been no way to accurately measure the size of the tiny vessels they created. Now,scientists at the National Institute of Standards and Technology have found a potential solution to this longstanding manufacturing issue. The NIST approach could meet an important need in the microfluidics industry, which creates devices ...

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    16. Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dual-modality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We ...

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    17. Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      We present an ultra-thin fiber-body endoscopy probe for optical coherence tomography (OCT) which is based on a stepwise transitional core (STC) fiber. In a minimalistic design, our probe was made of spliced specialty fibers that could be directly used for beam probing optics without using a lens. In our probe, the OCT light delivered through a single-mode fiber was efficiently expanded to a large mode field of 24 μm diameter for a low beam divergence. The size of our probe was 85 μm in the probe’s diameter while operated in a 160-μm thick protective tubing. Through theoretical and ...

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    18. Taiwanese researchers find way to detect skin cancer early

      Taiwanese researchers find way to detect skin cancer early

      A research team at prestigious National Taiwan University (NTU) has developed a non-invasive technology that can help detect melanoma, the most deadly type of skin cancers, by up to six months earlier than usual. The team hopes its high-speed and high resolution optical coherence tomography scanner can receive medical certification by as early as 2017 so that it can put it into clinical use as soon as possible. Diagnosing cancer relies primarily on observing tissues and cells, and that is where the scanner can be useful in a timely way, said Shun Chia-tung, a doctor with National Taiwan University Hospital ...

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    19. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

      Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

      Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused ...

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    20. Study shows new technology may improve management of leading causes of blindness

      Study shows new technology may improve management of leading causes of blindness

      Research published today in the Proceedings of the National Academy of Sciences (PNAS) demonstrates that technology invented by researchers at Oregon Health & Science University's Casey Eye Institute can improve the clinical management of the leading causes of blindness. Optical coherence tomography (OCT) angiography could largely replace current dye-based angiography in the management of these diseases. OHSU researchers found that OCT angiography has considerable advantages over conventional techniques for the diagnosis and management of macular degeneration, diabetic eye disease and glaucoma, the leading causes of blindness in the United States. "This is a significant breakthrough technology that could fundamentally change ...

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    21. Swept Source Optical Coherence Tomography in Ocular Diseases Special Interest Group at ARVO

      Swept Source Optical Coherence Tomography in Ocular Diseases Special Interest Group at ARVO

      Moderators: Ludwig M. Heindl(Center of Ophthalmology, University Hospital Cologne, Cologne, Germany) Robert J. Zawadzki (UC Davis Eye Center, University of California Davis, Sacramento, California, US) Speakers: Olaf Meiendresch (Topcon Medical, Willich, Germany) Albert Caramoy (Center of Ophthalmology, University Hospital Cologne, Cologne, Germany) Robert J. Zawadzki (UC Davis Eye Center, Sacramento, USA) Ireneusz Grulkowski (Nicolaus Copernicus University, Torun, Poland Wolfgang Drexler (Medical University of Vienna, Vienna Austria) Robert Huber (Institute of Biomedical Optics, University zu Lübeck, Germany) Organizing Section: Anatomy and Pathology/Oncology (AP) Contributing Sections: Cornea (CO), Glaucoma (GL), Retina (RE), Multidisciplinary Ophthalmic Imaging Group (MOI) Imaging using ...

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    22. Internal fingerprint acquisition from optical coherence tomography fingertip scans

      Internal fingerprint acquisition from optical coherence tomography fingertip scans

      Current surface fingerprint scanners measure the surface topography of skin, resulting in vulnerabilities to surface skin erosion, distortion due to contact with the scanner, and fingerprint counterfeiting. An improved means of fingerprint acquisition is necessitated in these facts. By employing an imaging technique known as Optical Coherence Tomography to the human fingertip skin, a three-dimensional digital reconstruction of subsurface layers of skin can be used for the extraction of an internal fingerprint. The internal fingerprint is robust towards counterfeiting, damage, and distortion, thus providing a replacement for the surface fingerprint. However, OCT scans are corrupted by speckle noise and have ...

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    23. Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE

      Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE

      Objective Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE. Methods Retinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLE patients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests. Results NPSLE ...

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    24. Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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