1. All Articles

    25-48 of 18578 « 1 2 3 4 5 ... 772 773 774 »
    1. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    2. Complex master slave interferometry

      Complex master slave interferometry

      A general theoretical model is developed to improve the novel Spectral Domain Interferometry method denoted as Master/Slave (MS) Interferometry. In this model, two functions, g and h are introduced to describe the modulation chirp of the channeled spectrum signal due to nonlinearities in the decoding process from wavenumber to time and due to dispersion in the interferometer. The utilization of these two functions brings two major improvements to previous implementations of the MS method. A first improvement consists in reducing the number of channeled spectra necessary to be collected at Master stage. In previous MSI implementation, the number of ...

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    3. A New Idea of Fast Three-Dimensional Median Filtering for Despeckling of Optical Coherence Tomography Images

      A New Idea of Fast Three-Dimensional Median Filtering for Despeckling of Optical Coherence Tomography Images

      Median filtering has been widely used in image processing for noise removal because it can significantly reduce the power of noise while limiting edge blurring. This filtering is still a challenging task in the case of three-dimensional images containing up to a billion of voxels, especially for large size filtering windows. The authors encountered the problem when applying median filter to speckle noise reduction in optical coherence tomography images acquired by the Spark OCT systems. In the paper a new approach to the GPU based median smoothing has been proposed, which uses two-step evaluation of local intensity histograms stored in ...

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    4. Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to 20 healthy volunteers (18 Female, 2 male). All the participants underwent optical coherence tomography (OCT) scan, electroretinogram (ERG), visual evoked potentials (VEP), and multifocal electroretinogram (mf-ERG) recording. Results: Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean VEP N80-P100 amplitudes ...

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    5. Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography

      AIM : To assess quantitative changes of the macula in diabetic eyes after cataract surgery using optical coherence tomography (OCT) and to estimate the incidence of development or worsening of macular edema (ME) in diabetic eyes with or without pre-existing ME. METHODS : In this prospective, observational study, 92 eyes of 60 diabetic patients who underwent cataract surgery were evaluated before surgery and 1, 3mo after surgery using OCT. Macular thickness was measured with OCT at nine macular subfields defined by the 9 zones early treatment of diabetic retinopathy study (ETDRS), as well as total macular volume obtained by OCT at 1 ...

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    6. Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

      Dear Sir, I write to present the correlation between microperimetric (MP) values and the density of myelinated retinal nerve fibers (MNFs) in optical coherence tomography (OCT) imaging. MNFs appear as white or gray-white striated patches that correspond in shape to the distribution of retinal nerve fibers and demonstrate frayed borders[1] . Visual system myelination normally begins at the optic tracts at 7mo of gestational age and progresses anteriorly, finishing within 3mo after birth and stopping at the lamina cribrosa. However, this process may progress beyond this level and cause retinal nerve fibers to become myelinated [2-4] . The incidence of MNFs ...

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    7. High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

      High-resolution handheld rigid endomicroscope based on full-field optical coherence tomography

      Full-field optical coherence tomography (FF-OCT) is a powerful tool for nondestructive assessment of biological tissue, i.e., for the structural examination of tissue in depth at a cellular resolution. Mostly known as a microscopy device for ex vivo analysis, FF-OCT has also been adapted to endoscopy setups since it shows good potential for in situ cancer diagnosis and biopsy guidance. Nevertheless, all the attempts to perform endoscopic FF-OCT imaging did not go beyond lab setups. We describe here, to the best of our knowledge, the first handheld FF-OCT endoscope based on a tandem interferometry assembly using incoherent illumination. A common-path ...

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    8. Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      Optical Coherence Tomography Angiography of the Retinal Microvasculature using the Zeiss AngioPlex

      AngioPlex optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
    9. Impact of Culprit Plaque and Atherothrombotic Components on Incomplete Stent Apposition in Patients With ST-Elevation Myocardial Infarction Treated With Everolimus-Eluting Stents – An OCTAVIA Substudy –

      Impact of Culprit Plaque and Atherothrombotic Components on Incomplete Stent Apposition in Patients With ST-Elevation Myocardial Infarction Treated With Everolimus-Eluting Stents – An OCTAVIA Substudy –

      Background: The role of culprit plaque and related atherothrombotic components on incomplete stent apposition (ISA) occurrence after primary percutaneous coronary intervention (p-PCI) is unknown. Methods and Results: ST-segment elevation myocardial infarction (STEMI) patients undergoing p-PCI with an everolimus-eluting stent were prospectively investigated with optical coherence tomography (OCT) of the infarct-related artery before, after stenting and at 9 months. OCT data, aspirated thrombus and serum inflammatory biomarkers were analyzed. 114 patients with 114 lesions were evaluated. Acute ISA occurred in 82 lesions (71.9%), preferentially in larger vessels with a median area of 0.2 mm 2 . The presence of thrombus ...

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    10. Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample

      Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample

      Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electromagnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure ...

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    11. Method and apparatus for imaging of vessel segments

      Method and apparatus for imaging of vessel segments

      An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to ...

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    12. Coronary optical coherence tomography: A practical overview of current clinical applications

      Coronary optical coherence tomography: A practical overview of current clinical applications

      Coronary optical coherence tomography has emerged as the most powerful in-vivo imaging modality to evaluate vessel structure in detail. It is a useful research tool that provides insights into the pathogenesis of coronary artery disease. This technology has an important clinical role that is still being developed. We review the evidence on the wide spectrum of potential clinical applications for coronary optical coherence tomography, which encompass the successive stages in coronary artery disease management: accurate lesion characterization and quantification of stenosis, guidance for the decision to perform percutaneous coronary intervention and subsequent planning, and evaluation of immediate and long-term results ...

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    13. St. Jude Medical Announces Launch of OPTIS Mobile System in Europe and Japan

      St. Jude Medical Announces Launch of OPTIS Mobile System in Europe and Japan

      St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the launch of the company’s OPTIS™ Mobile System in Japan and Europe. The diagnostic system is designed to couple state-of-the-art optical coherence tomography (OCT) and angiography co-registration with fractional flow reserve (FFR) technology into one portable system for hospitals with multiple catheterization labs. OPTIS Mobile Integrated Lab (Photo: Business Wire) Driven by a global increase in vascular disease and enabled by advances in technology, the catheterization lab allows physicians to use minimally invasive percutaneous coronary intervention (PCI) procedures that give patients an alternative to open heart ...

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      Mentions: St. Jude Medical
    14. Association between Cholesterol Crystals and Culprit Lesion Vulnerability in Patients with Acute Coronary Syndrome: an Optical Coherence Tomography Study

      Association between Cholesterol Crystals and Culprit Lesion Vulnerability in Patients with Acute Coronary Syndrome: an Optical Coherence Tomography Study

      Background Cholesterol Crystals (ChCs) are recognized as a hallmark of advanced atherosclerotic lesions. Previous animal and histopathology studies have revealed that Cholesterol crystallization trigger a local inflammatory response and plaque rupture. We sought to investigate the in vivo relationship between ChCs and culprit lesion vulnerability in patients with acute coronary syndrome (ACS). Methods 206 culprit lesions from 206 patients with ACS who underwent optical coherence tomography (OCT) imaging were divided into 2 groups based on the presence or absence of ChCs. Culprit lesions characteristics were compared between ChCs and Non-ChCs groups. Results For overall ACS patients, culprit lesions with ChCs ...

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      Mentions: Jingbo Hou Bo Yu
    15. The Volkswagen Foundation Grant In Biomedical Engineering

      The Volkswagen Foundation Grant In Biomedical Engineering

      The Volkswagen Foundation Grant in Biomedical Engineering . Scientists increasingly succeed in simulating processes of life within artificial systems or in developing novel artificial systems based on fundamental principles of life. These approaches seek a better understanding of fundamental principles of life, and in doing so they open up intriguing and novel perspectives on life to complement the philosophical view. With its initiative, The Volkswagen Foundation aims to support unique and excellent projects at the interface between the natural and life sciences with this particular focus. In view of the ambitious nature of this kind of research the Volkswagen Foundation is ...

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    16. Are Microcalcification and Hemosiderin Really Limitations of OCT in Detection of TCFA?

      Are Microcalcification and Hemosiderin Really Limitations of OCT in Detection of TCFA?

      With great interest, we read the recent work by Fujii et al. (1) published in iJACC reporting the diagnostic accuracy of optical coherence tomography (OCT) and grayscale intravascular ultrasound for the detection of coronary thin cap fibroatheroma (TCFA) with histologic validation in human autopsy hearts. In this publication, Fujii et al. (1) documented a limited capability of OCT and intravascular ultrasound for TCFA identification when each imaging device was solely utilized. The authors attributed the low accuracy of OCT in TCFA detection to 4 reasons: presence of foam cell macrophage, microcalcification, hemosiderin accumulation, and organizing thrombus inclusive of fibrin. However ...

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    17. Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina Assessment With OFDI

      Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina Assessment With OFDI

      Coronary artery spasm plays important roles in the pathogenesis of a wide range of ischemic heart disease. Recent studies have demonstrated that coronary spasm is frequently noted in Caucasians as in Asians (1) . We previously demonstrated that vascular smooth muscle cell hypercontraction through Rho-kinase activation is the key mechanism of the spasm, for which adventitial inflammatory changes may be involved (1) . The adventitia has recently attracted much attention as a source of inflammation as it harbors nutrient blood vessels called vasa vasorum (VV). Indeed, VV plays an important role as a supply route of vascular inflammation in the progression of ...

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    18. Contribution of optical coherence tomography imaging in management of iatrogenic coronary dissection

      Contribution of optical coherence tomography imaging in management of iatrogenic coronary dissection

      Iatrogenic coronary dissection is a rare but potentially serious complication of coronary angiography and angioplasty. Treatment with angioplasty guided only by angiography is often difficult. Optical coherence tomography imaging seems to be an interesting technique to lead the management of iatrogenic coronary dissection. Diagnosis can be made by optical coherence tomography; it can also eliminate differential diagnosis. Furthermore, this technique can guide safely the endovascular treatment.

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    19. Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

      Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

      Purpose : Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young’s modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods : The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results : The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial ...

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    20. Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques

      Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques

      Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaques in vivo in patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the applications of IVUS-OCT technology. Results from cadaver specimens are summarized, which indicated the complementary nature of OCT and IVUS for assessment of vulnerable plaques, plaque composition, and stent-tissue ...

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    21. Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis

      Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis

      Applications are invited for a post-doctoral research associate position in the UC Davis EyePod Small Animal Imaging Laboratory in the Department of Cell Biology and Human Anatomy at the UC Davis Main Campus. The goal of our research is to develop and translate the next generation in vivo cellular resolution multimodal retinal imaging instruments and data analysis tools and to apply them to disease mechanisms and therapeutic interventions that can be investigated in the eye. The ideal candidate will have strong skills in some combination of retinal/microscopic imaging modalities, including but not limited to adaptive optics (AO), OCT, SLO ...

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    22. Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      The metabolic syndrome (MS) is conceptualized as a clustering of risk factors-including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)-that increase the risk for cardiovascular disease and type 2 diabetes mellitus (DM) [1]. Metabolic syndrome is known to be a low-grade systemic inflammatory condition with its origins in the perinatal period and childhood, while recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis

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    23. Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Retinal Imaging Techniques for Diabetic Retinopathy Screening

      Due to the increasing prevalence of diabetes mellitus, demand for diabetic retinopathy (DR) screening platforms is steeply increasing. Early detection and treatment of DR are key public health interventions that can greatly reduce the likelihood of vision loss. Current DR screening programs typically employ retinal fundus photography, which relies on skilled readers for manual DR assessment. However, this is labor-intensive and suffers from inconsistency across sites. Hence, there has been a recent proliferation of automated retinal image analysis software that may potentially alleviate this burden cost-effectively. Furthermore, current screening programs based on 2-dimensional fundus photography do not effectively screen for ...

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    24. High resolution OCT system From NKT Photonics

      High resolution OCT system From NKT Photonics

      Optical Coherence Tomography (OCT) is a non-destructive analysis technique that can provide detailed information on refractive index variations and scattering on a micrometer scale for partly transmitting materials. Powered by our broadband SuperK EXTREME OCT laser in combination with the Thorlabs Ganymede OCT engine, the system provides an ultra high axial resolution of 1.2µm in tissue. With a lateral resolution down to 2.5µm, the system is a versatile tool for a multitude of applications ranging from tomography of small animals to non-destructive testing of industrial materials. The system is extremely flexible and allows the user to ...

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