1. All Articles

    25-48 of 14763 « 1 2 3 4 5 ... 614 615 616 »
    1. Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study

      Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study

      Purpose To compare intraocular lens implantation using a motorized injector vs standard manual injector through a 2.2-mm clear corneal incision. Methods Patients underwent standard phacoemulsification using a 2.2-mm clear corneal incision. Hydrophobic acrylic aspheric intraocular lens (Acrysof SN60WF intraocular lens (IOL)) was inserted using D cartridge with manual monarch injector or autosert motorized injector. IOL safety, final incision size and wound integrity in terms of anterior and posterior wound gape, and descemet’s membrane detachment were compared between the two groups at post-operative day 1 and at 1 month using Anterior Segment Optical Coherence Tomography. Results The study ...

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    2. Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Background —Recent reports show that plaque erosion can be diagnosed in vivo using optical coherence tomography (OCT) in patients with acute coronary syndromes (ACS). However, quantitative OCT image criteria for computer-aided diagnosis of plaque erosion have not been established. Methods and Results —A total of 42 patients with ACS caused by plaque erosion were included. Plaque erosion was identified according to the previously established OCT criteria. Both optical properties and morphological features of the focal eroded region as well as erosion-adjacent region were analyzed using a custom designed computer algorithm. Non-eroded fibrous plaques remote from the erosion site within the ...

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    3. Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy

      Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy

      Purpose: To evaluate the diagnostic accuracy of glaucoma in different stages, different types of glaucoma, and different ethnic groups using Stratus optical coherence tomography (OCT). Methods: We searched MEDLINE to identify available articles on diagnostic accuracy of glaucoma published between January 2004 and December 2011. A PubMed (National Center for Biotechnology Information) search using medical subject headings and keywords was executed using the following terms: "diagnostic accuracy" or "receiver operator characteristic" or "area under curve" or "AUC" and "Stratus OCT" and "glaucoma." The search was subsequently limited to publications in English. The area under a receiver operator characteristic (AUC) curve ...

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    4. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...

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    5. Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis

      Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis

      The occurrence of deteriorated coronary flow associated with distal embolization during percutaneous coronary intervention results in impaired myocardial perfusion and worsens the clinical prognosis. This study aimed to examine the impact of optical coherence tomography (OCT)-determined coronary plaque morphology on the prediction of deteriorated coronary flow after stent implantation in acute as well as stable coronary syndromes (ACS and SAP, respectively). We studied 126 patients who underwent OCT during stenting for ACS ( n = 44) and SAP ( n = 82) with a de novo lesion. Angiographic deteriorated coronary flow was defined as the deterioration of TIMI flow grade after mechanical dilatation ...

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    6. Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      The purpose of this study was to investigate changes in total retinal blood flow (RBF) using Doppler Fourier Domain Optical Coherence Tomography (Doppler FD‐OCT) in response to the manipulation of systemic partial pressure of CO 2 (P ET CO 2 ). Double circular Doppler blood flow scans were captured in nine healthy individuals (mean age ± standard deviation: 27.1 ± 4.1, six males) using the RTVue ™ FD‐OCT (Optovue). P ET CO 2 was manipulated using a custom‐designed computer‐controlled gas blender (RespirAct ™ ) connected to a sequential gas delivery rebreathing circuit. Doppler FD‐OCT measurements were captured at baseline ...

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    7. Light sheet imaging the Airy way

      Light sheet imaging the Airy way

      Recent decades have seen an expansion in the breadth of light-based imaging techniques that address problems in biomedicine. Despite perceived limitations in terms of penetration depth and resolution, optical imaging has made significant strides to encroach upon the traditional territory of other modalities, such as electron microscopy and x-ray. At the nanoscale, optical methods exploit light fields in tandem with the properties of fluorescent proteins to answer biological questions in neuroscience and virology that were previously restricted to electron microscopy. At the larger scale, the same methods are making headway to generate biopsies solely with light. A prime example is ...

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    8. To Be or not TB?

      To Be or not TB?

      Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...

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    9. Diagnosing Macular Degeneration: The Tests that Tell

      Diagnosing Macular Degeneration: The Tests that Tell

      Perhaps you suddenly notice what seems like a constant ‘smudge’ in your central vision. Or maybe straight lines are beginning to seem wavy or distorted. Often, these are the initial symptoms of age-related macular degeneration . Since catching macular degeneration early is imperative in successfully treating the condition, it’s important to acknowledge these symptoms and have a doctor test you for macular degeneration as soon as possible. Through several different tests, physicians can determine if a patient is at risk for AMD, what stage of the disease a patient is at- and how to best stop the disease from progressing ...

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    10. Do you know where your fillers go? An ultrastructural investigation of the lips

      Do you know where your fillers go? An ultrastructural investigation of the lips

      Aim: To investigate the exact location and position of hyaluronic acid fillers in the perioral region by ultrasound and optical coherence tomography. Introduction: To date, there are few in vivo investigations in humans on the exact positioning of injectable hyaluronic acid fillers, and severe complications such as hematoma and thromboembolism are rarely addressed. Materials and methods: There were nine female patients investigated in this pilot study. All of them were periorally injected with hyaluronic acid. The exact product, amount, and locations, as well as the injection techniques, were recorded and compared. Before, immediately after, and 18 days after injection, photo ...

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    11. Multi-Surface and Multi-Field Co-Segmentation of 3-D Retinal Optical Coherence Tomography

      Multi-Surface and Multi-Field Co-Segmentation of 3-D Retinal Optical Coherence Tomography

      When segmenting intraretinal layers from multiple optical coherence tomography (OCT) images forming a mosaic or a set of repeated scans, it is attractive to exploit the additional information from the overlapping areas rather than discarding it as redundant, especially in low contrast and noisy images. However, it is currently not clear how to effectively combine the multiple information sources available in the areas of overlap. In this paper, we propose a novel graphtheoretic method for multi-surface multi-field co-segmentation of intraretinal layers, assuring consistent segmentation of the fields across the overlapped areas. After 2D en-face alignment, all the fields are segmented ...

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    12. Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular cyclotorsion.

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      Mentions: Randy H. Kardon
    13. Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema

      Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema

      Background To compare the anatomic and functional results between optical coherence tomography (OCT)-guided selective focal laser photocoagulation (OCT–laser) and conventional modified Early Treatment Diabetic Retinopathy Study (mETDRS) laser treatment for diabetic macular edema (DME). Methods We analyzed treatment outcomes in 47 consecutive eyes treated with OCT–laser compared to 31 matched eyes treated with mETDRS. In the OCT–laser group, we identified ‘significant actively-leaking microaneurysms on OCT’ (SALMO) which are responsible for edema in OCT B-scan images, and thoroughly ablated them with photocoagulation. Best-corrected visual acuity (BCVA) and retinal thickness by OCT were compared at baseline and 12 ...

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    14. THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      Purpose: To report a novel spectral domain optical coherence tomography finding in exudative macular disease, called the pearl necklace sign. Methods: A retrospective case series of 21 eyes (20 patients) with chronic exudative maculopathy resulting from age-related macular degeneration, diabetic macular edema, branch retinal vein occlusion, retinal arterial macroaneurysm, and Coats disease. Spectral domain optical coherence tomography images were carefully evaluated and correlated with color fundus photography, near-infrared reflectance, and fluorescein angiography. Results: A unique spectral domain optical coherence tomography macular finding of hyperreflective dots in a contiguous ring around the inner wall of cystoid spaces in the outer plexiform ...

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      Mentions: K. Bailey Freund
    15. Photonics innovations win R&D 100 Awards

      Photonics innovations win R&D 100 Awards

      Super-resolution microscopes from Carl Zeiss and Leica Microsystems, a novel radiation detector from Brookhaven National Lab (BNL), and an origami microscope are among more than a dozen optics and photonics innovations to win one of this year's R&D 100 Awards. Intended to recognize the 100 "most technologically significant products" introduced over the past year, the list also includes an all-fiber isolator from AdValue Photonics, an optical coherence tomography (OCT) diagnostic endoscope developed by NinePoint Medical, and a lunar laser communication system co-developed by NASA and MIT's Lincoln Laboratory.

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    16. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used ...

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    17. Do You Hear That? It Sounds Like a Technology Breakthrough

      Do You Hear That? It Sounds Like a Technology Breakthrough

      The inner workings of the ear have been a mystery for decades. However, that’s all about to change thanks to the efforts of a team of researchers determined to shed some light on the hearing process. Researchers from Stanford University and Texas A&M are working on mapping the tissues of the cochlea, the portion of the inner ear responsible for hearing. To map the cochlea, they used a technique known as optical coherence tomography (OCT) on animal models. OCT is similar to ultrasound but generates very high-resolution images, along with terabytes of measurement data. This data must be ...

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    18. Avinger Enrolls First PAD Patient in VISION Global Clinical Trial

      Avinger Enrolls First PAD Patient in VISION Global Clinical Trial

      Avinger Inc., pioneer of the lumivascular approach for treating vascular disease announced today that Dr. John Pigott of Jobst Vascular Institute, Toledo, OH, enrolled the first patient in VISION. VISION is a global IDE clinical trial, approved by the FDA to evaluate Avinger’s PantherisTM catheter for the treatment of Peripheral Artery Disease (PAD). It is estimated that PAD affects 12 million people in the US alone. The PantherisTM system combines directional atherectomy capabilities with real-time intravascular visualization to remove plaque from blocked arteries. The minimally invasive catheter is designed to remove plaque, while avoiding the disruption of normal arterial ...

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    19. Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography

      Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography

      Purpose We sought to assess the corneal thickness of the epithelium and stroma in keratoconic and normal eyes by spectral-domain optical coherence tomography (SD-OCT). Methods Fifty-seven keratoconic and 20 normal eyes were studied. The eyes were examined by SD-OCT, and the keratoconic eyes were subdivided into 2 groups: those showing only smooth corneal thinning and corneal protrusion on the image (KC1 group) and those showing abnormalities in the Bowman layer or in the stroma, or in both (KC2 group). The thicknesses at the corneal vertex and at the superior, inferior, nasal, and temporal cornea 1.5 mm from the corneal ...

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    20. University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for Computational Ophthalmology

      University of California at San Diego Receives at 2014 NIH Grant for $188,364 for Computational Ophthalmology. The principal investigator is Linda Zangwill. The program began in 2014 and ends in 2014. Below is a summary of the proposed work. COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization ...

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    21. University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego receives NIH Grant for Studying Animal Structure and Function

      University of California at San Diego received a 2014 NIH Grant for $167,628 for Animal Structure and Function. The principal investigator is Dirk-Uwe Bartsch. The program began in 2014 and ends in 2015. Below is a summary of the proposed work. The Animal Structure and Function Module will provide new centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The recent growth in the number of faculty in the Department of Ophthalmology conducting animal structure ...

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    22. Anterior Segment Optical Coherence Tomography Guided Nd:YAG Laser Iridocystotomy in Post Traumatic Iris Cyst

      Anterior Segment Optical Coherence Tomography  Guided Nd:YAG Laser Iridocystotomy in  Post Traumatic Iris Cyst

      A 30 year old female presented with a large post traumatic iris cyst obstructing the visual axis, with a corneal scar inferiorly. Anterior segment optical coherence tomography (AS-OCT) was done to identify the areas of corneal attachment and locate the thinnest area of the cyst. Nd:YAG laser iridocystotomy performed subsequently resulted in immediate deflation of the cyst, excellent restoration of visual acuity and no recurrence till 6 months of follow up. AS-OCT guided laser cystotomy has not been reported previously, to the best of our knowledge.

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    23. In-vivo segmentation and quantification of coronary lesions by optical coherence tomography images for a lesion type definition and stenosis grading

      In-vivo segmentation and quantification of coronary lesions by optical coherence tomography images for a lesion type definition and stenosis grading

      Optical coherence tomography (OCT) is a catheter-based medical imaging technique that produces cross-sectional images of blood vessels. This technique is particularly useful for studying coronary atherosclerosis. In this paper, we present a new framework that allows a segmentation and quantification of OCT images of coronary arteries to define the plaque type and stenosis grading. These analyses are usually carried out on-line on the OCT-workstation where measuring is mainly operator-dependent and mouse-based. The aim of this program is to simplify and improve the processing of OCT images for morphometric investigations and to present a fast procedure to obtain 3D geometrical models ...

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    24. En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and In Vivo Confocal Microscopy

      En-face Optical Coherence Tomography as a Novel Tool for Exploring the Ocular Surface: A Pilot Comparative Study to Conventional B-Scans and In Vivo Confocal Microscopy

      Purpose To explore the potential of spectral-domain optical coherence tomography (SD-OCT) using the en-face technology for the imaging of ocular surface diseases and to correlate the findings with in vivo confocal microscopy (IVCM) images. Patients and methods 113 eyes of 75 subjects with various ocular surface diseases were investigated with the RTVue ® anterior-segment en face OCT. En face OCT images were compared to B-scans OCT and IVCM images. Results: Patients with corneal dystrophies, corneal deposits, keratitis, pterygium, conjunctivochalasis, or ocular surface squamous neoplasia and patients who underwent lamellar corneal surgeries were included. En face OCT images showed ocular surface tissue ...

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