1. All Articles

    25-48 of 17071 « 1 2 3 4 5 ... 710 711 712 »
    1. Stereopsis And Optical Coherence Tomography Findings After Epiretinal Membrane Surgery

      Stereopsis And Optical Coherence Tomography Findings After Epiretinal Membrane Surgery

      Purpose: To evaluate stereopsis in patients undergoing vitrectomy for epiretinal membrane and to investigate the relationship between stereopsis and foveal microstructures. Methods: This study included 55 eyes of 55 patients who underwent vitrectomy for unilateral epiretinal membrane and 27 age-matched normal subjects. We examined stereopsis using the Titmus Stereo Test, TNO stereotest, and, optical coherence tomography before surgery and 6 months after surgery. Central foveal thickness, central retinal thickness at the parafovea (CRT-3 mm), macular volume, and retinal layer thickness were measured with the optical coherence tomography software and an image-processing program. Results: Epiretinal membrane surgery significantly improved stereopsis in ...

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    2. Classification Of Sclerochoroidal Calcification Based On Enhanced Depth Imaging Optical Coherence Tomography “MOUNTAIN-LIKE” Features

      Classification Of Sclerochoroidal Calcification Based On Enhanced Depth Imaging Optical Coherence Tomography “MOUNTAIN-LIKE” Features

      Purpose: To describe distinct enhanced depth optical coherence tomography patterns of sclerochoroidal calcification and their correlation to clinical features. Methods: Retrospective chart review of 67 eyes of 46 patients with spectral domain optical coherence tomography imaging. Results: The mean patient age at diagnosis was 68 years. There were 20 (43%) men and 26 (57%) women of white (n = 45, 98%) or Hispanic (n = 1, 2%) heritage. The most prominent sclerochoroidal calcification lesions were located in the superotemporal quadrant (n = 57, 85%) between the temporal arcades and the equator (n = 58, 87%). On enhanced depth optical coherence tomography, the sclerochoroidal calcification ...

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    3. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives NIH Grant  for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      The University of Illinois Urbana-Champaign Receives a 2015 NIH Grant for $490,333 for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investigator is Stephen Boppart. The program begain in 2012 and ends in 2017. Below is a summary of the proosed work. Margin status during the surgical treatment of solid tumors is the most critical factor in determining local recurrence rates. For breast cancer, breast conserving surgeries or lumpectomies are routinely performed. Currently, the surgeon is unable to visualize the microscopic structure at the margin, and conventionally relies on post-operative histological assessment of surgical margins to ...

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    4. Evaluation of eye tissue elasticity by means of sound propagation speed measuring in vivo

      Evaluation of eye tissue elasticity by means of sound propagation speed measuring in vivo

      Introduction: To date, it has never been demonstrated the propagation sound speed in human corneas and lens in vivo. With the advent of Optical Coherence Tomography (OCT), it became possible to determine the dimensions of the ocular tissues without the interference of sound propagation speed and to use this information to define the real propagation sound speed for each patient and individualized structure. Aim: To determine the sound propagation speed in the cornea and lens from patients that theoretically exhibits differences in tissue elasticity (normal corneas and keratoconus, corneas of young and elderly patients, in addition to clear crystalline lens ...

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    5. Attenuation coefficient of the light in skin of BALB/c and C57BL/6 mice

      Attenuation coefficient of the light in skin of BALB/c and C57BL/6 mice

      Optical properties of the biological tissue play an important role to a correct use of optical techniques for therapy and diagnosis. The mice skin presents morphological differences due to characteristics such as gender, body mass and age. Murine models are frequently used in pre-clinical trials in optical therapy and diagnosis. Therefore, the assessment of the skin tissue in animal models is needed for a proper understanding of how light interacts with skin. Noninvasive techniques such as optical coherence tomography (OCT) have been used to obtain optical information of the tissue, as the attenuation coefficient, with the advantage of obtaining sectional ...

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    6. Study of lumineers' interfaces by means of optical coherence tomography

      Study of lumineers' interfaces by means of optical coherence tomography

      OCT has been used to evaluate dental materials, and is employed here to evaluate lumineers for the first time. Lumineers are used as esthetical indirect restoration, and after wearing and aging, several undesirable features such as gaps, bubbles and mismatch can appear in which would only be seen by invasive analysis. The OCT (spectral domain SD-OCT, 930nm central wavelength) was used to evaluate noninvasively the lumineer- cement-tooth interface. We analyzed 20 specimens of lumineers-teeth that were prepared in bovine teeth and randomly allocated in 4 experimental groups (n=5) with two different cementation techniques and two different types of cementing ...

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    7. Visual Outcomes, Visual Fields, and Optical Coherence Tomography in Paediatric Craniopharyngioma

      Visual Outcomes, Visual Fields, and Optical Coherence Tomography in Paediatric Craniopharyngioma

      Ten patients with craniopharyngioma treated for the first time when younger than 18 were included. This study reviews the visual outcomes and provides information on visual field (VF) and optical coherence tomography (OCT) examination of craniopharyngioma. The best kappa concordance coefficients between VF and OCT parameters of atrophy were obtained for the ganglion cell (GC) thickness and the mean retinal nerve fibre layer (RNFL) thickness. The agreement between GC colour maps and VF defects was good. Optic nerve compression may be detected by RNFL measurement and GC analysis, and this may be valuable to predict visual recovery and in uncooperative ...

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    8. Optical Coherence Tomography; A Modern Technique to Detect Oral Mucosal Lesion: A Review

      Optical Coherence Tomography; A Modern Technique to Detect Oral Mucosal Lesion: A Review

      Early detection and management of potentially malignant oral lesions can significantly reduce progression of these lesions into invasive cancer, and would thus reduce morbidity and fatality rate. Cancerous and potentially malignant lesions show dysplastic feature which is mostly detected by biopsy. However, biopsy has a certain constraints like (i) biopsy can cause delay in the result, (ii) experienced pathologist must expound the biopsy sample (iii) sometimes can cause spread of cancer cells, (iv) cannot be done repeatedly. Therefore, in potentially malignant lesions and cancer optical coherence tomography (OCT) is utilized to detect early dysplastic changes. Therefore, we are presenting a ...

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    9. Comparative analysis of gingival phenotype in animal and human experimental models using optical coherence tomography in a non-invasive approach

      Comparative analysis of gingival phenotype in animal and human experimental models using optical coherence tomography in a non-invasive approach

      Imaging methods are widely used in diagnostic and among the diversity of modalities, optical coherence tomography (OCT) is nowadays commercially available and considered the most innovative technique used for imaging applications, in both medical and non-medical applications. In this study, we exploit the OCT technique in the oral cavity for identification and differentiation between free and attached gingiva, as well as determining the gingival phenotype, an important factor to determination of periodontal prognosis in patients. For the animal studies, five porcine jaws were analyzed using a Swept Source SS-OCT system operating at 1325nm and stereomicroscope, as gold pattern. The SSOCT ...

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    10. Analysis of photodynamic cream effect in dental caries using optical coherence tomography

      Analysis of photodynamic cream effect in dental caries using optical coherence tomography

      The aim of this study was to assess the effect in the enamel demineralization of low-intensity infrared laser (λ=810 nm, 100 mW/cm 2 , 90 sec, 4.47 J/cm 2 , 9 J) with or without photodynamic cream fluorinated or not fluorinated, using Optical Coherence Tomography (OCT). Background data: Lasers can be used as tools for the prevention of tooth enamel demineralization. All enamel specimens (n= 105) were analyzed using OCT at baseline, and randomly assigned into seven groups (n=15): C (+), laser application; C(-), no treatment; (F), acid fluoride gel; cream (IV); cream and neutral fluoride (IVF); cream and ...

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    11. New speckle analysis method for optical coherence tomography signal based on autocorrelation

      New speckle analysis method for optical coherence tomography signal based on autocorrelation

      Optical Coherence Tomography (OCT) is a noninvasive imaging technique with high resolution widely used for in vivo applications. Nonetheless, OCT is prone to speckle, a granular noise that degrades the OCT signal. Speckle statistics may, nevertheless, reveal information regarding the scatterers from which it originates. This fact is exploited by techniques such as Speckle Variance-OCT (SVOCT). SVOCT, however, doesn’t provide quantitative information, which is a major drawback for the use of speckle based techniques on OCT. In the present work we attack this problem, proposing a new method for analysis of speckle in OCT signal, based on autocorrelation. We ...

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    12. Optical coherence tomography applied to the evaluation of wear of composite resin for posterior teeth

      Optical coherence tomography applied to the evaluation of wear of composite resin for posterior teeth

      Resin composites are widely used as restorative materials due to their excellent aesthetical and mechanical properties. Posterior teeth are constantly submitted to occlusal stress and upon restoration require more resistant resins. The aim of this study was to analyze in vitro the wear suffered over time by restorations in resin composite in posterior teeth, by Optical Coherence Tomography (OCT). 30 molars had occlusal cavities prepared and were randomly divided into three groups (n=10) and restored with resin composite: G1: Filtek P90 (3M/ESPE), G2: Tetric N-Ceram (Ivoclar Vivadent); G3: Filtek P60 (3M/ESPE). Specimens were subjected to initial analysis ...

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    13. New speckle analysis algorithm for flow visualization in optical coherence tomography images

      New speckle analysis algorithm for flow visualization in optical coherence tomography images

      Optical Coherence Tomography (OCT) is a noninvasive technique capable of generating in vivo high-resolution images. However, OCT images are degraded by a granular and random noise called speckle. Nevertheless, such a noise may be used to gather information regarding the sample, as is exploited by techniques like Speckle Variance – OCT (SV-OCT). SV-OCT is widely used in the literature, but the variance calculation is computationally expensive. Therefore, we propose a new algorithm to employ speckle in identifying flow based on the evaluation of intensity fluctuation between two consecutively acquired OCT images. Our results were compared to those obtained by traditional method ...

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    14. Quantitative Comparison of Retinal Capillary Images Derived By Speckle Variance Optical Coherence Tomography With Histology

      Quantitative Comparison of Retinal Capillary Images Derived By Speckle Variance Optical Coherence Tomography With Histology

      Purpose. The purpose of this study was to correlate human retinal capillary network information derived from a prototype speckle variance optical coherence tomography (svOCT) device with histology to determine the utility of this instrument for quantitative angiography. Methods. A retina location 3 mm superior to the optic disk was imaged with svOCT in 14 healthy human eyes. Qualitative and quantitative features of capillary networks, including capillary diameter and density, were compared with perfusion-labeled histological specimens from the same eccentricity. Twelve human donor eyes with no history of eye disease were used for histological comparisons. Results. svOCT was able to clearly ...

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    15. New technology looks into the eye and brings cells into focus

      New technology looks into the eye and brings cells into focus

      Eye doctors soon could use computing power to help them see individual cells in the back of a patient’s eye, thanks to imaging technology developed by engineers at the University of Illinois. Such detailed pictures of the cells, blood vessels and nerves at the back of the eye could enable earlier diagnosis and better treatment for degenerative eye and neurological diseases. New technology uses computational techniques to more clearly see individual rods and cones, the cells that detect light in the back of the eye | Graphic by Alex Jerez Roman The technique applies adaptive optics – the method astronomers use ...

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    16. Rapid fabrication system for three-dimensional tissues using cell sheet engineering and centrifugation

      Rapid fabrication system for three-dimensional tissues using cell sheet engineering and centrifugation

      Three-dimensional (3-D) tissues can be reconstructed by cell sheet technology, and various clinical researches using these constructed tissues have already been initiated to regenerate damaged tissues. While 3-D tissues can be easily fabricated by layering cell sheets, the attachment period for cell adhesion between a cell sheet and a culture dish, or double-layered cell sheets normally takes 20-30 min. This study proposed a more rapid fabrication system for bioengineered tissue using cell sheet technology and centrifugation. A C2C12 mouse myoblast sheet harvested from a temperature-responsive culture dish will attach tightly to a culture dish or another cell sheet at 37 ...

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    17. Association of Intravascular Ultrasound- and Optical Coherence Tomography-Assessed Coronary Plaque Morphology With Periprocedural Myocardial Injury in Patients With Stable Angina Pectoris

      Association of Intravascular Ultrasound- and Optical Coherence Tomography-Assessed Coronary Plaque Morphology With Periprocedural Myocardial Injury in Patients With Stable Angina Pectoris

      Background: Periprocedural myocardial injury (PMI) is not an uncommon complication and is related to adverse cardiac events after percutaneous coronary intervention (PCI). We investigated the predictors of PMI in patients with stable angina pectoris (SAP) on intravascular imaging. Methods and Results: We enrolled 193 SAP patients who underwent pre-PCI intravascular ultrasound (IVUS) and optical coherence tomography (OCT). Clinical characteristics, lesion morphology, and long-term follow-up data were compared between patients with and without PMI, defined as post-PCI elevation of high-sensitivity cardiac troponin-T. PMI were observed in 79 patients (40.9%). Estimated glomerular filtration rate (odds ratio [OR], 0.973; 95% confidence ...

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    18. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY EVIDENCE OF RETINAL NERVE FIBER LAYER AND GANGLION CELL LOSS IN ADULT PATIENTS WITH NEUROFIBROMATOSIS TYPE 1

      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY EVIDENCE OF RETINAL NERVE FIBER LAYER AND GANGLION CELL LOSS IN ADULT PATIENTS WITH NEUROFIBROMATOSIS TYPE 1

      Purpose: To evaluate peripapillary retinal nerve fiber layer, macular retinal nerve fiber layer, and ganglion cell layer-inner plexiform layer thickness and analyze their correlations in adult patients with neurofibromatosis Type 1 (NF1) and disease-free controls. Methods: This cross-sectional study was performed at the Azienda Policlinico Umberto I, University of Rome "La Sapienza." All participants underwent complete ophthalmologic examination. Spectral domain optical coherence tomography was used to evaluate peripapillary retinal nerve fiber layer and obtain retinal segmentation measurements to assess macular retinal nerve fiber layer and ganglion cell layer-inner plexiform layer at 1,000 [mu]m nasal, temporal, superior, and inferior ...

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    19. CHOROIDAL THICKNESS IN RELATION TO ETHNICITY MEASURED USING ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      CHOROIDAL THICKNESS IN RELATION TO ETHNICITY MEASURED USING ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To investigate the posterior choroidal thickness in healthy subjects of three different ethnicities. Methods: In this prospective cross-sectional study, the choroidal thickness of 88 individuals (176 eyes) was measured using enhanced depth imaging-spectral domain optical coherence tomography. Subfoveal choroidal thickness was measured between the retinal pigment epithelium-Bruch membrane complex and chorioscleral interface. Nasal, temporal, superior, and inferior choroidal thicknesses at 0.5, 1.5, and 3.0 mm locations from the fovea were evaluated as well. Results: Males and females were perfectly matched by number in all groups. The mean age of the entire study population was 27.43 ...

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    20. Surgical microscopes using optical coherence tomography and related systems

      Surgical microscopes using optical coherence tomography and related systems

      Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls ...

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    21. Apparatus, method and system for performing phase-resolved optical frequency domain imaging

      Apparatus, method and system for performing phase-resolved optical frequency domain imaging

      Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component ...

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    22. Broadband infrared light emitting device

      Broadband infrared light emitting device

      There is provided a broadband infrared light emitting device that radiates infrared light having a band broader than a conventional broadband infrared light emitting device. [MEANS FOR SOLVING] The broadband infrared light emitting device at least includes: a light source 4 that emits first excitation light .lamda.1 in a first wavelength range; a first glass phosphor 51 that has an excitation band in a first wavelength range, and when the first excitation light .lamda.1 is incident thereon, emits second excitation light .lamda.2 in a second wavelength range and first infrared light .lamda.3 in a third wavelength ...

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    23. Flexible waveguides for optical coherence tomography

      Flexible waveguides for optical coherence tomography

      A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the ...

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    24. Severe spasm of the left main and spontaneous intramural haematoma: a serial optical coherence tomography study

      Severe spasm of the left main and spontaneous intramural haematoma: a serial optical coherence tomography study

      A 41-year-old woman developed acute myocardial infarction after salbuterol abuse. Coronary angiography showed narrowing of the left main (LM) and of the proximal left anterior descending artery (LAD), and a hazy subocclusion of the mid LAD. Manual and rheolytic thrombectomy were performed without retrieving thrombus and improving flow. Due to haemodynamic instability, we deployed a drug-eluting stent (DES) and performed a first optical coherence tomography (OCT) scan, demonstrating severe spasm of the distal LM, and an extensive intramural haematoma of the proximal LAD, possibly squeezed proximally and distally by stent implantation (Figure 1, top row) . We hypothesised intramural haematoma since ...

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