1. All Articles

    25-48 of 21635 « 1 2 3 4 5 ... 900 901 902 »
    1. INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes

      INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes

      Purpose: To investigate the structural changes of intrapapillary proliferations associated with optic disk pits (ODPs) and optic disk pit maculopathy (ODP-M) using enhanced depth-spectral domain-optical coherence tomography (SD-EDI-OCT) and megahertz optical coherence tomography (MHz-OCT). Methods: Sixteen eyes of patients with ODPs were studied. Papillary and peripapillary areas were repeatedly examined with SD-EDI-OCT over time. To evaluate swept-source OCT, some of the patients additionally received MHz-OCT-imaging. Results: MHz-OCT or SD-EDI images showed the entire form of the pits from opening to bottom in 13 of the 16 cases. The shape of ODPs varied considerably. In patients with unilateral ODP, deep intrapapillary ...

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    2. DIRECTIONAL CHANGES IN TISSUE REFLECTIVITY MAY INFLUENCE FLOW DETECTION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      DIRECTIONAL CHANGES IN TISSUE REFLECTIVITY MAY INFLUENCE FLOW DETECTION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To determine if directional or anatomical changes in tissue reflectivity of Henle fiber layer (HFL) may influence flow detection on optical coherence tomography angiography (OCT-A). Methods: Cross-sectional analysis of consecutive cases undergoing OCT-A. Directional changes in visualization of HFL were either produced manually by moving the beam entrance within the pupil or observed occurring naturally because of tilting of the OCT line-scan within a myopic staphyloma. Areas of enhanced HFL visualization were identified on cross-sectional and en face structural OCT scans. Visualization of OCT-A flow within the superficial and the deep capillary plexuses were compared in areas with and ...

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      Mentions: K. Bailey Freund
    3. Fully Automated Robust System to Detect Retinal Edema, Central Serous Chorioretinopathy, and Age Related Macular Degeneration from Optical Coherence Tomography Images

      Fully Automated Robust System to Detect Retinal Edema, Central Serous Chorioretinopathy, and Age Related Macular Degeneration from Optical Coherence Tomography Images

      Maculopathy is the excessive damage to macula that leads to blindness. It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD). Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities. However, to the best of our knowledge, no research that presents a fully automated system to detect all of these macular syndromes is reported. This paper presents the world’s first ever decision support system to automatically detect RE, CSCR, and ARMD ...

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    4. Image-Guided Laparoscopic Surgical Tool (IGLaST) Based on the Optical Frequency Domain Imaging (OFDI) to Prevent Bleeding

      Image-Guided Laparoscopic Surgical Tool (IGLaST) Based on the Optical Frequency Domain Imaging (OFDI) to Prevent Bleeding

      We present an image-guided laparoscopic surgical tool (IGLaST) to prevent bleeding. By applying optical frequency domain imaging (OFDI) to a specially designed laparoscopic surgical tool, the inside of fatty tissue can be observed before a resection, and the presence and size of blood vessels can be recognized. The optical sensing module on the IGLaST head has a diameter of less than 390 µm and is moved back and forth by a linear servo actuator in the IGLaST body. We proved the feasibility of IGLaST by in vivo imaging inside the fatty tissue of a porcine model. A blood vessel with ...

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      Mentions: Korea University
    5. Intravitreal cysticercosis with full thickness macular hole: management outcome and intraoperative optical coherence tomography features

      Intravitreal cysticercosis with full thickness macular hole: management outcome and intraoperative optical coherence tomography features

      Ocular cysticercosis is a serious condition with a potential for complete vision loss if left untreated. Intravitreal cysticercosis is the most common ocular form of cysticercosis and is associated with retinal detachment, retinal traction, subretinal scarring and vitritis. To the best of our knowledge, there is no report of the occurrence of a live intravitreal cysticercosis with a full thickness macular hole (FTMH) in the literature. We here report a case of live intravitreal cysticercosis with a FTMH along with its management and intraoperative optical coherence tomography features of the live cysticercus.

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    6. Optical coherence tomography-guided PCI

      Optical coherence tomography-guided PCI

      I read with great interest the results of the ILUMIEN III trial by Ziad Ali and colleagues (Nov 26, p 2618–28), 1 which did not show superiority for optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) compared with angiography-guided PCI. No difference was found in the primary endpoint—minimum stent area after PCI—between the two strategies (p=0·12). Although guidance by OCT resulted in fewer untreated dissections than did guidance by angiography (39 vs 61, p=0·006), this difference was driven by an increase in the number of minor dissections in the angiography group compared ...

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    7. Optical coherence tomography-guided PCI – Authors' reply

      Optical coherence tomography-guided PCI – Authors' reply

      We read with interest the Correspondence by Rahman Shah regarding our 2016 ILUMIEN III: OPTIMIZE PCI trial. 1 In nearly all previous studies of percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) or optical coherence tomography (OCT), the most important predictor of follow-up events was the minimum stent area, followed by edge dissections and untreated disease. 2 , 3 Nine randomised trials 4 have compared IVUS guidance versus angiography guidance for PCI with drug-eluting stents (DES). IVUS guidance improved event-free survival by achieving larger acute stent dimensions than angiography guidance. 4 Therefore, before embarking on a definitive trial comparing OCT-guided ...

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    8. Assessment of enamel cracks at adhesive cavosurface margin using three-dimensional swept-source optical coherence tomography

      Assessment of enamel cracks at adhesive cavosurface margin using three-dimensional swept-source optical coherence tomography

      Objectives Swept-source optical coherence tomography (SS-OCT) can construct cross-sectional images of internal biological structures. The aim of this study was to evaluate enamel cracks at the cavosurface margin of composite restorations using SS-OCT. Methods Bowl-shaped cavities were prepared at two locations (mid-coronal and cervical regions) on the enamel surface of 60 bovine teeth. Half of the cavities (30) were treated with phosphoric acid gel. A two-step self-etch adhesive (Clearfil SE Bond) was applied to all cavities and a flowable composite was placed in bulk. After 7 days in water at 37 °C, three-dimensional (3D) images of the specimens were obtained ...

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    9. Second-Generation OCT Module Goes the Extra Mile

      Second-Generation OCT Module Goes the Extra Mile

      Device features increased speed and higher image contrast. D avid M. Brown, MD, a retinal physician with Retina Consultants of Houston, in Texas, was prompted to upgrade to Heidelberg Engineering’s OCT2 module for the Spectralis diagnostic imaging platform because of its increased scanning speed and throughput. “I increasingly found that the process of obtaining optical coherence tomography (OCT) caused patient flow to bottleneck at my practice,” he says. “The OCT2 module helps to mitigate that issue. I can obtain a complete volume scan within 12 to 15 seconds for each eye that is precisely image tracked to the last ...

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    10. Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects

      Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects

      bjectives The objective was to investigate the acute mechanical effects of post-dilatation on bioresorbable scaffolds (BRS) as determined by optical coherence tomography (OCT). Background Post-dilatation with high-pressure balloons is regarded as a key component of BRS implantation for treatment of coronary artery stenoses. However, the impact of post-dilatation on BRS in vivo has not been thoroughly investigated. Methods OCT was performed after the implantation procedure of 51 everolimus-eluting or novolimus-eluting polylactic acid-based BRS with ( n = 27) or without non-compliant balloon post-dilatation ( n = 24). The number of malapposed struts, strut fractures, edge dissections, residual in-scaffold area stenosis, and incomplete scaffold apposition ...

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    11. Optical Coherence Tomography in Neuroretinitis: Epipapillary Infiltrates and Retinal Folds

      Optical Coherence Tomography in Neuroretinitis: Epipapillary Infiltrates and Retinal Folds

      Neuroretinitis is a form of papillitis associated with the delayed onset of an exudative macular star among other inflammatory ocular findings. We describe 4 patients with neuroretinitis who displayed several distinctive and novel findings on spectral-domain optical coherence tomography (OCT) that include "epipapillary infiltrates" and an atypical pattern of inner retinal folds. The recognition of these findings on OCT may help in the early diagnosis of neuroretinitis.

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    12. Role of Disorganization of Retinal Inner Layers as an Optical Coherence Tomography Biomarker in Diabetic and Uveitic Macular Edema

      Role of Disorganization of Retinal Inner Layers as an Optical Coherence Tomography Biomarker in Diabetic and Uveitic Macular Edema

      The role of optical coherence tomography (OCT) in characterizing normal and pathologic retinal architecture is still evolving. Numerous groups have tried to use OCT findings of retinal features as a surrogate for visual acuity in macular edema, but no traditional measure consistently accounts for visual outcomes. Retina specialists are still trying to process the data in the literature regarding this topic, as no good review currently exists. Dilraj S. Grewal, MD, and Glenn J. Jaffe, MD, provide us with an overview of the literature and focus on the role of disorganization of the retinal inner layers (DRIL) as an OCT ...

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      Mentions: Duke University
    13. Optical Coherence Tomography Angiography Features in Melanocytoma of the Optic Nerve

      Optical Coherence Tomography Angiography Features in Melanocytoma of the Optic Nerve

      Optic disc melanocytoma (ODM) is a pigmented tumor with malignant potential characterized clinically as a dark brown to black lesion with feathery margins. The authors report a case of ODM and describe the utility of optical coherence tomography angiography (OCTA) in detecting superficial tumor vascularization. This case report demonstrated the ability of OCTA to reveal the fine abnormal retinal vasculature on the surface of the lesion, a characteristic of ODM, which has been previously correlated with tumor growth.

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    14. Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part Ι): Blood flow velocity imaging

      Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part Ι): Blood flow velocity imaging

      The research goal of the microvascular network imaging with optical coherence tomography (OCT) angiography is to achieve depth resolved blood flow and vessel imaging in vivo in the clinical management of patents. In this review, we review the main phenomena that have been explored in OCT to image the blood flow velocity vector and the vessels of the microcirculation within living tissues. Parameters that limit the accurate measurements of blood flow velocity are then condisered. Finally, initial Clinic diagnosis applications of and future developments are discussed.

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    15. Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part ΙΙ): Microvascular network imaging

      Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part ΙΙ): Microvascular network imaging

      In this work, we review the main phenomena that have been explored in OCT angiography to image the vessels of the microcirculation within living tissues with the emphasis on how the different processing algorithms were derived to circumvent specific limitations. Parameters are then discussed that can quantitatively describe the depth-resolved microvascular network for possible clinic diagnosis applications. Finally,future directions in continuing OCT development are discussed.

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    16. Choriocapillaris Changes Imaged by OCT Angiography After Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Choriocapillaris Changes Imaged by OCT Angiography After Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      BACKGROUND AND OBJECTIVE: To evaluate the choriocapillaris using optical coherence tomographic angiography (OCTA) after half-dose verteporfin photodynamic therapy (hd-PDT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: We studied six eyes (six patients) with chronic CSC treated by hd-PDT. OCTA was performed before, 1 week after, and 1 month after hd-PDT. The area of flow abnormality at the choriocapillaris level within the PDT spot after hd-PDT was compared with that before hd-PDT. RESULTS: Serous retinal detachment was diminished in all eyes, with three achieving complete resolution at 1 month. On OCTA, all eyes showed irregular choriocapillaris flow before hd-PDT ...

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    17. Measurements of the parapapillary atrophy zones in en face optical coherence tomography images

      Measurements of the parapapillary atrophy zones in en face optical coherence tomography images

      Objective To measure the parapapillary atrophy (PPA) area in en face images obtained with swept-source optical coherence tomography (SS-OCT), and to evaluate its relationship to glaucoma, myopia, and age in non-highly myopic subjects. Design Retrospective, cross-sectional study. Participants Fifty eyes of 30 subjects with open-angle glaucoma (G group) and forty-three eyes of 26 healthy control subjects (C group). Eyes with high myopia (spherical equivalent refractive error ≤ -8 diopters or axial length ≥ 26.5 mm) were excluded. Methods Mean age ± standard deviation was 59.9 ± 12.4 years. The beta zone and the gamma zone PPA areas were measured in en ...

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    18. Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis

      Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis

      A 74-year-old man presented 6 hours after sudden painless vision loss in the left eye. He had finger counting vision, normal intraocular pressure, and an afferent pupillary defect. Diagnosis of central retinal artery occlusion was made. Optical coherence tomography angiography performed before (Fig 1 A , C ) and immediately after (Fig 1 B , D ) anterior chamber paracentesis showed dramatic improvement in macular perfusion. Vision was 20/70 at the 1-month visit. Optical coherence tomography at presentation showed acute inner retinal opacification (Fig 1 E ), whereas 10 months later (Fig 1 F ) it illustrated partial preservation of inner retinal laminations, which we ...

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    19. Re: Yarmohammadi et al.: Relationship between optical coherence tomography angiography vessel density and severity of visual field loss in glaucoma (Ophthalmology. 2016;123:2498-2508)

      Re: Yarmohammadi et al.: Relationship between optical coherence tomography angiography vessel density and severity of visual field loss in glaucoma (Ophthalmology. 2016;123:2498-2508)

      To the Editor: We read with interest the article by Yarmohammadi et al. 1 The authors evaluated the association between vessel density measurements using optical coherence tomography angiography and the severity of visual field loss in primary open-angle glaucoma. They found a significant relationship between vessel density and severity of visual field damage. We have 2 questions. First, participants with spherical refraction within ±10 diopters were included. However, results from a recent study 2 showed that high myopia has a major influence on peripapillary vessel density and retinal nerve fiber layer thickness. Thus, to achieve more accurate conclusions, participants with ...

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    20. Swept-source Optical Coherence Tomography Angiography Imaging in a Case of Uveal Melanoma

      Swept-source Optical Coherence Tomography Angiography Imaging in a Case of Uveal Melanoma

      A 52-year-old man was referred to our ocular oncology department for evaluating a uveal mass in his right eye. Fundus examination revealed an amelanotic, mushroom-shaped choroidal melanoma in the nasal periphery (Fig 1 A ) measuring 8 mm in diameter and 5.9 mm in thickness at B-scan ultrasonography (Fig 1B). Swept-source optical coherence tomography angiography (Fig 1 C ) (Zeiss PLEX Elite 9000) allowed a comprehensive study of the mass despite its unfavorable position and thickness with excellent visualization of its intrinsic vasculature and details comparable to indocyanine green angiography (Fig 1 D ). Seven months after stereotactic radiosurgery the patient is ...

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    21. How to Acquire High-Resolution Anatomic Ocular Tissue Information with Optical Coherence Tomography (OCT): Leica Science Lab

      How to Acquire High-Resolution Anatomic Ocular Tissue Information with Optical Coherence Tomography (OCT): Leica Science Lab

      OCT was first demonstrated in 1991 and was quickly recognized as an important tool in ophthalmology, rapidly becoming the standard of care in retinal diagnostics. Today, OCT is one of the most frequently ordered diagnostic tests. OCT technology is continually evolving, becoming increasingly popular in clinical and non-clinical imaging applications, including ophthalmic surgery, gastrointestinal imaging and interventional cardiology. OCT functions by a process very similar to ultrasound – except, of course, that is uses light instead of sound. Low intensity, near-infrared (NIR) light is directed at the patient. A small amount of this light is reflected back to the system and ...

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    22. Volumetric laser endomicroscopy in the management of Barrett's esophagus

      Volumetric laser endomicroscopy in the management of Barrett's esophagus

      Purpose of review: The incidence of esophageal adenocarcinoma is on the rise despite widespread appreciation that the precursor lesion is Barrett's esophagus. Studies have shown that some patients known to have Barrett's esophagus develop cancer despite their enrollment in conventional endoscopic surveillance programs. This highlights the need for advanced endoscopic imaging to help identify early neoplasia and prevent its progression to esophageal cancer. Recently, a wide-field, second-generation optical coherence tomography endoscopic platform called volumetric laser endomicroscopy (VLE) was cleared by the Food and Drug Administration and made commercially available for advanced imaging in Barrett's esophagus. Recent findings ...

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