1. All Articles

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    1. Spectral-Domain Optical Coherence Tomography Measurements of Choroidal Thickness and Outer Retinal Disruption in Macular Telangiectasia Type 2

      Spectral-Domain Optical Coherence Tomography Measurements of Choroidal Thickness and Outer Retinal Disruption in Macular Telangiectasia Type 2

      To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared with healthy eyes. PATIENTS AND METHODS: In this prospective, observational, cohort study, 62 patients (62 eyes) with Mac-Tel2 and 130 healthy controls (130 eyes) underwent a complete ophthalmological examination, spectral-domain optical coherence tomography (SD-OCT) imaging, and axial length measurements. Patients in the study group also underwent color fundus photography, fundus autofluorescence, and fluorescein angiography. En face SD-OCT imaging was used to assess abnormalities involving the photoreceptor inner segment/outer segment/ellipsoid zone (IS/OS/EZ). RESULTS: After adjusting ...

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    2. A Quantitative Evaluation of the Posterior Segment of the Eye Using Spectral-Domain Optical Coherence Tomography in Carotid Artery Stenosis: a Pilot Study

      A Quantitative Evaluation of the Posterior Segment of the Eye Using Spectral-Domain Optical Coherence Tomography in Carotid Artery Stenosis: a Pilot Study

      BACKGROUND AND OBJECTIVE: To evaluate the posterior segment of the eye using spectral-domain optical coherence tomography (SD-OCT) in patients with internal carotid artery (ICA) stenosis. PATIENTS AND METHODS: Prospective study enrolling 25 patients with ICA stenosis (study group) and 25 age- and gender-matched healthy individuals (control group). Macular choroidal thickness (CT) was measured at the fovea; other CT measurements were taken 1,000 µm away from the fovea in the nasal, temporal, superior, and inferior regions by enhanced-depth imaging OCT (EDI-OCT). The thicknesses of the retinal nerve fiber layer (RNFL), macula, and ganglion cell complex (GCC) were measured with SD-OCT ...

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    3. OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      Michelson Diagnostics , the UK-based medical device company focused on multi-beam Optical Coherence Tomography technology, has closed the £2.5m first tranche of its “Series B” financing, led by strategic investor and medical specialist Smith & Nephew alongside new investor Kent County Council as well as existing investors. The £2.5m investment will be used to expand Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-center clinical biopsy avoidance study; and explore further applications in wound care and dentistry. VivoSight is a point-of-care tissue-imaging system that for the first time ...

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    4. Development and Receding of a Coronary Artery Aneurysm After Implantation of a Fully Bioresorbable Scaffold

      Development and Receding of a Coronary Artery Aneurysm After Implantation of a Fully Bioresorbable Scaffold

      A 83-year-old man included in the ABSORB cohort B trial underwent successful percutaneous coronary intervention of the middle left anterior descending artery with a 3.0×18-mm bioresorbable scaffold (Absorb, Abbott Vascular, CA) that was postdilated with a 3.0-mm noncompliant balloon at 24 atm (Figure 1A and 1B). The 2-dimensional and 3-dimensional (3D) optical coherence tomography (OCT) confirmed the absence of structural discontinuity after the procedure (Figure 2B and Figure 3A’). At 6 months, the planned angiography showed the absence of restenosis but an ectasia in the scaffolded segment (Figure 1C). Intravascular ultrasound revealed a focal vessel and lumen ...

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    5. Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser has now been developed for use in the treatment of atherosclerotic cardio-vascular disease. DWH Systems, Inc. of Seminole Florida working with ELAN Vascular Technologies has developed a system whereby three OCT imaging heads monitor a femtosecond ablation laser in real-time, to perform micro ablation on the outer surface of diseased arteries. OCT is used first to acquire a 3D, C-scan map of the diseased portion of an artery then develops an ablation map for the system to follow. As ablation is performed, OCT again monitors the lasers cutting process from multiple angles in ...

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    6. Optical Coherence Tomography Optical Fiber Assembly Capabilities

      Optical Coherence Tomography Optical Fiber Assembly Capabilities

      OFS , a designer, manufacturer, and supplier of fiber optic products, has introduced new OCT optical fiber assembly capabilities. OFS has developed a technology platform to build optical fiber probes with flexible tip lensing designs to meet critical OCT imaging specifications such as: insertion loss, internal back reflection, beam size and working distance. The company says that because it is vertically integrated with preform (glass) manufacturing, it can make a wide range of fibers with features such as select cutoff, specific numerical apertures, graded index fibers and coreless fibers. Furthermore, polishing and fiber tip shaping skills allow them to assemble custom ...

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    7. James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      On February 19 th , the birthday of Nicolaus Copernicus, Professor James G. Fujimoto was awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University in Poland. Professor Fujimoto was awarded the University’s highest academic distinction, Doctor Honoris Causa, by Rector Andrzej Tretyn and Dean Andrzej Kowalczyk in recognition of his contribution to the fields of biomedical optics and medicine, his training and mentoring of young scientists, and his service to the international scientific community. Presentation of the Honorary Doctorate to Prof. Fujimoto by Dean Andrzej Kowalczyk (left) and Rector Andrzej Tretyn (right), photo by Andrzej Romański. The Copernicus University ...

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    8. Frequency combs in molecular fingerprint region

      Frequency combs in molecular fingerprint region

      Silicon nanowire optical waveguides dramatically broaden mid-infrared frequency comb spectra, scientists report. Frequency combs are commercially available in the visible and near-infrared spectral ranges. The mid-infrared spectral region (2-20?m), however, is still emerging. Many applications in spectroscopy, material science, security and industry process control, or chemical, biological and medical sensing would straightforwardly take advantage of mid-infrared photonics devices of higher performance.

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    9. Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      We provide a framework for compensating errors within passive optical quadrature demodulation circuits used in swept-source optical coherence tomography (OCT). Quadrature demodulation allows for detection of both the real and imaginary components of an interference fringe, and this information separates signals from positive and negative depth spaces. To achieve a high extinction (∼60 dB) between these positive and negative signals, the demodulation error must be less than 0.1% in amplitude and phase. It is difficult to construct a system that achieves this low error across the wide spectral and RF bandwidths of high-speed swept-source systems. In a prior work ...

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    10. Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      This study describes microleakage sensing based on swept-source optical coherence tomography (SS-OCT). With a handheld scanning probe, the SS-OCT system can provide portable real-time imaging for clinical diagnosis. Radiography is the traditional clinical imaging instrument used for dentistry; however, it does not provide good contrast images between filling material and the enamel of treated teeth with microleakage. The results of this study show that microleakage can be detected with oral probing using SS-OCT in vivo . The calculated microleakage length was 401  μ m and the width is 148  μ m, which is consistent with the related histological biopsy measurements. The diagnosis of ...

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    11. The changing rates and indications of optical coherence tomography and fundus fluorescein angiography over 5 years

      The changing rates and indications of optical coherence tomography and fundus fluorescein angiography over 5 years

      Purpose. To evaluate the relative frequency of use of fundus fluorescein angiography (FFA) following the introduction of optical coherence tomography (OCT) at a tertiary university ophthalmology practice. Methods. We retrospectively analyzed the demand for and indications of all requests for FFA or OCT during the five years from 2007 to 2011, inclusively, at our tertiary care university hospital department of ophthalmology. Results. In January 2007, out of 194 total imaging studies requested and performed, there were 85 OCTs (43.8% of total imaging studies) and 109 FFAs (56.2%). By January 2011, out of 172 total imaging studies requested and ...

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    12. Feature Of The Week 02/22/15: Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      Feature Of The Week 02/22/15:  Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time-consuming process where the quantification of cardiac defects can be difficult due to problems with accurate section registration. Here we demonstrate the advantages of using optical coherence tomography, a comparatively new and rising technology, to phenotype avian embryo hearts in a model of Fetal Alcohol Syndrome where a binge-like quantity of alcohol/ethanol was introduced at gastrulation. The rapid, consistent imaging protocols allowed for the immediate identification of cardiac anomalies, including ventricular septal defects and misaligned/missing vessels. Interventricular septum ...

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    13. Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Aims: Residual thrombus accumulation around stent struts has been observed after the end of primary PCI and may represent a risk factor for acute stent thrombosis. The aim of this study is to test whether a strategy of prolonged bivalirudin infusion may reduce thrombosis of stent struts as compared to an intraprocedural only administration in subjects undergoing primary PCI. Methods and results: One hundred and sixty patients will be selected from the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) study with all the following inclusion criteria: a) STEMI patients undergoing primary PCI with stent implantation, b ...

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    14. Real-time epidural anesthesia guidance using optical coherence tomography needle probe

      Real-time epidural anesthesia guidance using optical coherence tomography needle probe

      Epidural anesthesia is one of the most widely used anesthesia methods. Due to lack of visual feedback to guide needle navigation, failure rate of epidural anesthesia is up to 20%, and the complication rate of peripheral nerve block approaches 10%, with the potential of permanent nerve damage. To address these difficulties, needle insertion under ultrasound guidance and fluoroscopy has been introduced. However, they do not provide adequate resolution and contrast to distinguish the tissue layers that the needle travels through or to specifically identify the epidural space. To improve the accuracy of epidural space identification, we developed a small hand-held ...

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    15. Algorithms for improved 3-D reconstruction of live mammalian embryo vasculature from optical coherence tomography data

      Algorithms for improved 3-D reconstruction of live mammalian embryo vasculature from optical coherence tomography data

      Background: Robust reconstructions of the three-dimensional network of blood vessels in developing embryos imaged by optical coherence tomography (OCT) are needed for quantifying the longitudinal development of vascular networks in live mammalian embryos, in support of developmental cardiovascular research. Past computational methods [such as speckle variance (SV)] have demonstrated the feasibility of vascular reconstruction, but multiple challenges remain including: the presence of vessel structures at multiple spatial scales, thin blood vessels with weak flow, and artifacts resulting from bulk tissue motion (BTM). Methods: In order to overcome these challenges, this paper introduces a robust and scalable reconstruction algorithm based on ...

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    16. Anterior segment optical coherence tomography evaluation of ocular graft-versus-host disease: a case study

      Anterior segment optical coherence tomography evaluation of ocular graft-versus-host disease: a case study

      To explore ocular graft-versus-host disease (GVHD), anterior segment optical coherence tomography (AS-OCT) imaging of eyelids, tear meniscus, cornea and conjunctiva is performed in subsequent sessions on a patient who has ocular GVHD after allogeneic related donor stem cell transplant. The OCT results are presented together with those from a normal subject. OCT imaging is promising in visualizing several ocular GVHD manifestations, such as abnormal meibomian gland orifice (MGO), conjunctival keratinization, conjunctival hyperemia and chemosis, corneal epithelium opacification, thinning and sloughing. This case study demonstrates the capability of AS-OCT in the imaging and monitoring of ocular GVHD, which may be useful ...

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    17. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Background: Endocervical mucus acts as an important barrier to block human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). Disruption of the mucus layer increases the risk of infection for females. An effective method to image the mucus properties can serve as a pre-screening step to risk-stratify the susceptible population. Methods: We proposed to use optical coherence tomography (OCT) to quantitatively measure the thickness of endocervical mucus. We used a home-built bench-top OCT system to monitor the dynamic change in mucus thickness of a cultivated sample. We also fabricated a prototype endoscopic OCT probe to demonstrate potential in ...

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    18. Spontaneous coronary artery dissection associated with ascending aorta dystrophy : a tear for fear

      Spontaneous coronary artery dissection associated with ascending aorta dystrophy : a tear for fear

      A 36-year old man with a recent history of aortic valve surgery for ascending aorta aneurysm was admitted for a non-ST elevation myocardial infarction. Cardiac MRI depicted a limited necrotic lesion in the anterior wall. Coronary angiography showed no significant stenosis, but a mild distal dynamic tortuosity on left anterior descending artery. Optical coherence tomography analysis confirmed the absence of any significant atherosclerotic infiltration but revealed the presence of a localized short arterial dissection within the kinked zone. The patient was managed with a conservative medical approach. The subsequent evolution was uneventful.

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    19. Dynamic imaging of accommodation by swept-source anterior segment optical coherence tomography

      Dynamic imaging of accommodation by swept-source anterior segment optical coherence tomography

      Purpose To study the accommodation process in normal eyes using a commercially available clinical system based on swept-source anterior segment optical coherence tomography (AS-OCT). Setting Ophthalmology Department, University of Parma, Italy. Design Evaluation of diagnostic technology. Methods Right eyes were analyzed using swept-source AS-OCT (Casia SS-1000). The optical vergence of the internal coaxial fixation target was adjusted during imaging to obtain monocular accommodation stimuli with different amplitudes (0, 3.0, 6.0, and 9.0 diopters [D]). Overlapping of real and conjugate OCT images enabled imaging of all the anterior segment optical surfaces in a single frame. Central corneal thickness ...

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    20. How We Can Use Light to See Inside the Human Body

      How We Can Use Light to See Inside the Human Body

      Human flesh is opaque. As any good dictionary will tell you, that means it has the quality of "n ot transmitting light; being impenetrable to sight." Well, forget that: scientists now can use light to see inside objects that were traditionally off-limits to the human eye—including our bodies. Of course it's already possible to use X-rays, MRI, ultrasound and the like to peer inside human beings, but results are never as crisp and clear as those acquired using visible light imaging. Not only that: optical wavelengths also interact with organic molecules—the one we're made of—so ...

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    21. Haag-Streit UK finalises an exciting agenda for Optometry Tomorrow 2015

      Haag-Streit UK finalises an exciting agenda for Optometry Tomorrow 2015

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce that it will be exhibiting at this year’s Optometry Tomorrow event in Brighton, on the 8th and 9th March, 2015. HS-UK will be exhibiting on stand 30, where it will be showcasing a large selection of its product portfolio, including the recently launched iScan and iFusion OCT devices, the Eidon true colour confocal scanner, DRS retinal camera, Perkins applanation tonometer and Tonosafe disposable prisms. The fully-automated iScan OCT, is easy-to-use and requires minimal training. It has a small footprint and is ...

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    22. Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      We demonstrate three-dimensional structural and functional retinal imaging with line-field parallel swept source imaging (LPSI) at acquisition speeds of up to 1 MHz equivalent A-scan rate with sensitivity better than 93.5 dB at a central wavelength of 840 nm. The results demonstrate competitive sensitivity, speed, image contrast and penetration depth when compared to conventional point scanning OCT. LPSI allows high-speed retinal imaging of function and morphology with commercially available components. We further demonstrate a method that mitigates the effect of the lateral Gaussian intensity distribution across the line focus and demonstrate and discuss the feasibility of high-speed optical angiography ...

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    23. Spectral domain optical coherence tomography imaging of mucopolysaccharidoses I, II, and VI A

      Spectral domain optical coherence tomography imaging of mucopolysaccharidoses I, II, and VI A

      Purpose The purpose of this study was to describe the spectral domain optical coherence tomography (SD-OCT) characteristics of patients with retinal manifestations of mucopolysaccharidoses (MPSs) I, II, and IV A. Design The research was a prospective, observational study. Methods Fourteen consecutive patients with variants of MPS and 15 healthy subjects underwent ophthalmic assessments including fundus examinations and SD-OCT. Results The fundus examinations revealed that four patients (two MPS I and two MPS II ) had pigmented retinopathy in both eyes. In addition, one MPS II patient had cystoid macular edema and two MPS II patients had abnormal disc morphology. SD-OCT revealed ...

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    24. Comparison of Strut Coverage at Six Months by Optical Coherence Tomography with Everolimus Eluting Stent or Bare-Metal Stent Restenosis –vs- Stenosis of Non-Stented Atherosclerotic Narrowing (from the DESERT Study)

      Comparison of Strut Coverage at Six Months by Optical Coherence Tomography with Everolimus Eluting Stent or Bare-Metal Stent Restenosis –vs- Stenosis of Non-Stented Atherosclerotic Narrowing (from the DESERT Study)

      Incomplete struts coverage is a predictor of late stent thrombosis after drug eluting stent (DES) implantation in atherosclerotic lesions. The process of struts coverage in DES implanted for bare-metal stent (BMS) restenosis has never been described. Thirty-two patients with stable coronary artery disease were consecutively selected, 11 with BMS restenosis (group A) and 21 with de-novo atherosclerotic lesions (group B). All patients underwent everolimus eluting stent implantation; coronary angiography and optical coherence tomography (OCT) were performed at 6-month follow-up. Percentage difference in struts coverage between the two groups was the primary end-point. A total of 85773 struts (17891 in group ...

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