1. All Articles

    25-48 of 20237 « 1 2 3 4 5 ... 842 843 844 »
    1. Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Background To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them. Methods Thirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location. Agreement was analyzed by mean difference (AS-OCT minus IVCM), 95 % limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis. Results The average ...

      Read Full Article
    2. The effectiveness of optical coherence tomography for evaluating peri-implant tissue: A pilot study

      The effectiveness of optical coherence tomography for evaluating peri-implant tissue: A pilot study

      Purpose Optical coherence tomography (OCT) has been investigated as a novel diagnostic imaging tool. The utilisation of this equipment has been evaluated through several studies in the field of dentistry. The aim of this preliminary study was to determine through basic experiments the effectiveness of OCT in implant dentistry. Materials and Methods To assess detection ability, we captured OCT images of implants in each of the following situations: (1) implants covered with mucosae of various thicknesses that were harvested from the mandibles of pigs; (2) implants installed in the mandibles of pigs; and (3) implants with abutments and crowns fixed ...

      Read Full Article
    3. SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      Purpose: Swept Source Optical Coherence Tomography validates lamina cribrosa anomaly in optic disk pit. Method: Observational case report. Results: A 25-year-old African American male presented with decreased vision in right eye of 4 days duration. Best corrected visual acuity (BCVA) for distance in right eye was 20/200 and in left eye was 20/20. Dilated fundus examination of right eye showed serous macular detachment of entire posterior pole along with an optic pit on temporal margin of optic disk. En-face image of the optic disk on Swept source OCT (SS-OCT) confirmed defect in the lamina cribrosa in the right ...

      Read Full Article
    4. Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images

      Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images

      We demonstrate the usefulness of utilizing a segmentation step for improving the performance of sparsity based image reconstruction algorithms. In specific, we will focus on retinal optical coherence tomography (OCT) reconstruction and propose a novel segmentation based reconstruction framework with sparse representation, termed segmentation based sparse reconstruction (SSR). The SSR method uses automatically segmented retinal layer information to construct layer-specific structural dictionaries. In addition, the SSR method efficiently exploits patch similarities within each segmented layer to enhance the reconstruction performance. Our experimental results on clinical-grade retinal OCT images demonstrate the effectiveness and efficiency of the proposed SSR method for both ...

      Read Full Article
    5. Automated Internal Classification of Beadless Chinese ZhuJi Fleshwater Pearls based on Optical Coherence Tomography Images

      Automated Internal Classification of Beadless Chinese ZhuJi Fleshwater Pearls based on Optical Coherence Tomography Images

      Optical coherence tomography (OCT) has been applied to inspect the internal defect of beadless Chinese ZhuJi fleshwater pearls. A novel fully automated algorithm is proposed to classify between normal and defective sub-layer in nacre layer. Our algorithm utilizes the graph segmentation approach to estimate the up and down boundaries of defect sub-layers from flattened and cropped image, and also proposes the strategy for edge and weight construction in segmentation process. The vertical gradients of boundary pixels are used to make grading decision. The algorithm is tested by typical pearl samples, and achieves 100% classification accuracy. The experiment result shows the ...

      Read Full Article
    6. Medical image processing apparatus for examining an eye to determine the stage of glaucoma

      Medical image processing apparatus for examining an eye to determine the stage of glaucoma

      This invention is directed towards a medical image processing apparatus capable of providing effective information on glaucoma by integrating the tomographic image of the retina obtained by an optical coherence tomograph (OCT: Optical Coherence Tomography) and visual function information obtained by a perimeter. The medical image processing apparatus associates visual field measurement results with a fundus camera image (S420). The medical image processing apparatus registers, on the fundus camera image associated with the visual field measurement results, a layer thickness distribution which is obtained from an OCT tomographic image and indicates the thickness of the nerve fiber layer in the ...

      Read Full Article
    7. System and method for creating and utilizing multivariate paths for ongoing simultaneous multi-dimensional control to attain single mode sweep operation in an electromagnetic radiation source

      System and method for creating and utilizing multivariate paths for ongoing simultaneous multi-dimensional control to attain single mode sweep operation in an electromagnetic radiation source

      A method for sweeping an electromagnetic radiation source (12) to produce single mode operation having an optimized side-mode suppression ratio over a continuous range of wavelengths within a prescribed temporal profile, the electromagnetic radiation source is configured to output electromagnetic radiation at a given wavelength based upon parameters. The method includes determining a set of parameter combinations that satisfy a condition for a desired set of wavelengths and a maximum side mode suppression ratio over the range of wavelengths. The set of parameter combinations define sub-paths for transitioning from one wavelength to another wavelength. Combinations of select sub-paths provide a ...

      Read Full Article
    8. High Speed Data Acquisitioni n Swept Source Optical Coherence Tomography

      High Speed Data Acquisitioni n Swept Source Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is an imaging technique especially popular in the medical field, developed to obtain information about the morphology of living biological tissue through cross-sectional images with micrometer resolution. One of the most common applications is the visualization of the eye. In the last decade considerable breakthroughs in this technique have happened, mostly due to the improvement of resolution, sensitivity, dynamic range and acquisition speed. An OCT system is being developed from scratch at IBILI to be used for small animal imaging, namely of the eye. Animals with anatomical resemblance to humans are often used in biomedical research ...

      Read Full Article
    9. Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg Engineering received 510(k) clearance from the FDA to market the Spectralis OCT Glaucoma Module Premium Edition, which creates an anatomic map unique to each patient’s eye. The module provides clinicians with objective and automatic measurement parameters for increased diagnostic accuracy, according to a company press release. It utilizes a new technology called Anatomic Positioning System, which uses the center of the fovea and the center of Bruch’s membrane opening to create an anatomic map of the eye. Each scan thereafter is automatically oriented according to each patient’s unique anatomic eye map. In addition, the module ...

      Read Full Article
    10. Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      This study was supported by the Werner H. Spross Foundation (Zurich, Switzerland). The ‘Stiftung wissenschaftliche Forschung, Fonds Ophthalmologie, City Hospital Triemli’ received research grants from Novartis Schweiz AG and Bayer Schweiz AG and payments for invited talks or advisory board participations for M.B and S.M. from Allergan, Novartis, Alimera, Bayer, Roche and Clanotech. None of the authors above has any conflict of interest related to this research. This study was presented as an e-poster (POS- 6771) at the 15th EURETINA Congress in Nice, France (17. – 20.09.2015).

      Read Full Article
      Mentions: Stephan Michels
    11. An Evaluation of Computational Imaging Techniques for Heterogeneous Inverse Scattering

      An Evaluation of Computational Imaging Techniques for Heterogeneous Inverse Scattering

      Inferring internal scattering parameters for general, heterogeneous materials, remains a challenging inverse problem. Its difficulty arises from the complex way in which scattering materials interact with light, as well as the very high dimensionality of the material space implied by heterogeneity. The recent emergence of diverse computational imaging techniques, together with the widespread availability of computing power, present a renewed opportunity for tackling this problem. We take first steps in this direction, by deriving theoretical results, developing an algorithmic framework, and performing quantitative evaluations for the problem of heterogeneous inverse scattering from simulated measurements of different computational imaging configurations.

      Read Full Article
    12. The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      Immunosuppressed transplant recipients have increased risk for the development of basal cell carcinoma skin cancers. While oral vismodegib therapy has been successful in treating locally advanced basal cell tumors, few studies document its use and efficacy in organ transplant patients. In this immunocompromised population, topical imiquimod 5% cream has been shown to be an effective and well-tolerated option for superficial and nodular basal cell carcinomas. To the authors' knowledge, no data documents the use of optical coherence tomography, a noninvasive imaging technique, to monitor progress of such combined therapies on in vivo skin. The authors report the successful treatment of ...

      Read Full Article
    13. Adaptive optics full-field optical coherence tomography

      Adaptive optics full-field optical coherence tomography

      We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level. As a consequence, an image-based algorithm was applied for the optimization process by using the FFOCT image intensity as the metric. Aberration corrections were demonstrated with both an USAF resolution ...

      Read Full Article
    14. In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical coherence tomography (SD-OCT) was employed for depth-resolved retinal imaging. A custom-designed animal holder equipped with ear bar and bite bar was used to minimize eye movements. Dynamic OCT imaging revealed ...

      Read Full Article
      Mentions: Xincheng Yao
    15. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin ...

      Read Full Article
    16. Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection: The Stardust Sign

      Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection:  The Stardust Sign

      Purpose: To report the retinal findings and evolution of a visually symptomatic case of West Nile virus meningoencephalitis. Methods: Case report. Main outcome measures include serologic testing for West Nile virus as well as longitudinal funduscopic examination, fluorescein angiography, and spectral domain optical coherence tomography. Results: A 47-year-old diabetic man was referred for ophthalmic evaluation after hospitalization and treatment for West Nile meningoencephalitis. The patient presented with decreased vision and black spots in the right eye. Baseline visual acuity was 20/100 in the right eye and 20/40 in the left. Funduscopic examination and fluorescein angiography revealed multiple outer-retinal ...

      Read Full Article
      Mentions: Rui Wang
    17. Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Purpose To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. Methods This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5–18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Results Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had ...

      Read Full Article
    18. Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      The Glaucoma Module Premium Edition for SPECTRALIS provides a comprehensive analysis of the optic nerve head, retinal nerve fiber layer, and ganglion cell layer by precisely matching unique scan patterns to the fine anatomic structures relevant in glaucoma diagnostics. By means of a new proprietary technology called the Anatomic Positioning System, the module creates an anatomic map unique to each patient’s eye using two fixed, structural landmarks: the center of the fovea and the center of Bruch’s membrane opening. All subsequent scan protocols are automatically oriented according to each eye’s unique anatomic map, enabling a precise examination ...

      Read Full Article
    19. Postdoctoral Associate: Biophotonics and Computer Vision Stanford University, Stanford, CA

      Postdoctoral Associate: Biophotonics and Computer Vision Stanford University, Stanford, CA

      The Stanford Biomedical Optics Group (http://sbo.stanford.edu), in close collaboration with clinical researchers in the School of Medicine (urology), seeks highly motivated postdoctoral candidates with excellent computer programming and image processing skills along with a good background in optics, microscopy or medical imaging and interest or experience in computer vision. Stanford University provides an outstanding environment for solid technical research with clinical impact. Applicants will work closely with clinical collaborators and will spend a significant amount of time observing and guiding clinical research activities while working on a heavily computer vision programming-oriented research project. Time permitting, candidate may ...

      Read Full Article
    20. New fingerprinting technology will aid law enforcement

      New fingerprinting technology will aid law enforcement

      The CSIR has unveiled a new-generation fingerprint sensing technology to aid in law enforcement and forensic areas. The device, funded by the Department of Science and Technology, is the first prototype, and the next step will be to reduce its size to a hand-held gadget and prepare it for commercialisation. The system is capable of exploring the internal features of an object. Laser scientist Ann Sigh said optical coherence tomography used light to capture in 3D the finest of details from biological tissue and could be likened to ultrasound but using light. She said it was important to note that ...

      Read Full Article
    21. Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Background and aims volumetric laser endomicroscopy (VLE) provides a circumferential scan that enables the visualization of subsurface layers of the esophageal wall at 7 μm resolution. The aims of this study were to identify VLE features ofBarrett’s esophagus (BE) neoplasia and to develop a VLE prediction score. Methods A database of VLE images from endoscopic resection specimens, precisely correlated with histology, from BE patients +/- neoplasia was used. Features potentially predictive for early BE neoplasia were identified by unblinded evaluation of 25 VLE-histology images. In a learning phase, 20 VLE images with or without BE neoplasia were scored by 2 ...

      Read Full Article
    22. Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from ...

      Read Full Article
    23. Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      This is a 3-year, pharmacologically non-interventional study to evaluate OCT as an outcome measure in patients with relapsing remitting multiple sclerosis (RRMS). Approximately 350 RRMS patients, either untreated or treated with an approved MS disease-modifying therapy and approximately 70 reference subjects without ophthalmologic or neurologic disease are enrolled. No study medications are provided. Patients on disease-modifying therapy are treated according to the local prescribing information. For each MS patient and each reference subject, the study consists of Screening (up to 1 month), Baseline, and a 36-month longitudinal data collection phase. Eligibility will be confirmed during Screening.

      Read Full Article
    24. Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions. The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm 2 and 0.270 ± 0.090 mm 2 , respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the ...

      Read Full Article
    25-48 of 20237 « 1 2 3 4 5 ... 842 843 844 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Optical Coherence Tomography News

    See all Optical Coherence Tomography News articles
  4. Organizations in the News

    1. (640 articles) Harvard University
    2. (540 articles) Massachusetts General Hospital
    3. (517 articles) Massachusetts Institute of Technology
    4. (513 articles) National Institutes of Health
    5. (407 articles) Duke University
    6. (342 articles) Johns Hopkins University
    7. (342 articles) University of Miami
    8. (341 articles) Medical University of Vienna
    9. (310 articles) FDA
    10. (307 articles) University of Southern California
  5. People in the News

    1. (356 articles) James G. Fujimoto
    2. (250 articles) David Huang
    3. (247 articles) Joseph A. Izatt
    4. (230 articles) Ruikang K. Wang
    5. (199 articles) Guillermo J. Tearney
    6. (197 articles) Stephen A. Boppart
    7. (188 articles) Adrian G. Podoleanu
    8. (184 articles) Zhongping Chen
    9. (174 articles) Brett E. Bouma
    10. (170 articles) Patrick W. Serruys
  6. OCT Companies in the News

    1. (1466 articles) Carl Zeiss Meditec
    2. (767 articles) St. Jude Medical
    3. (571 articles) Heidelberg Engineering
    4. (501 articles) Optovue
    5. (338 articles) Topcon Medical Systems
    6. (329 articles) Volcano Corporation
    7. (239 articles) Michelson Diagnostics
    8. (211 articles) Bioptigen
    9. (190 articles) Thorlabs
    10. (142 articles) Axsun Technologies