1. All Articles

    25-48 of 23127 « 1 2 3 4 5 ... 962 963 964 »
    1. Optical coherence tomography findings in Parkinson's disease

      Optical coherence tomography findings in Parkinson's disease

      The aim of this study is to compare optical coherence tomography (OCT) findings of retinal thickness (RT) and retinal nerve fiber layer thickness (RNFLT) of idiopathic Parkinson's disease (IPD) patients to those of healthy subjects, and to investigate whether there is any relationship between the severity of the disease and the RNFLT values. This prospective study was included 25 IPD patients and 29 healthy controls. In the IPD group, the Hoehn and Yahr (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), and Mini-Mental State Exam (MMSE) were performed. Intraocular pressure (IOP), visual acuity (VA), spherical equivalent, axial length ...

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    2. Detection of Silent Type I Choroidal Neovascular Membrane in Chronic Central Serous Chorioretinopathy Using En Face Swept-Source Optical Coherence Tomography Angiography

      Detection of Silent Type I Choroidal Neovascular Membrane in Chronic Central Serous Chorioretinopathy Using En Face Swept-Source Optical Coherence Tomography Angiography

      Purpose . To evaluate the efficacy of SS-OCTA in the detection of silent CNV secondary to chronic CSCR compared to that of FFA and SS-OCT. Patients and Methods . A retrospective observational case series reviewing the clinical data, FFA, SS-OCT, and SS-OCTA images of patients with chronic CSCR, and comparing the findings. SS-OCTA detects the CNV complex and delineates it from the surrounding pathological features of chronic CSCR by utilizing the blood flow detection algorithm, OCTARA, and the ultrahigh-definition B-scan images of the retinal microstructure generated by swept-source technology. The bivariate correlation procedure was used for the calculation of the correlation matrix ...

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    3. Automated Segmentation and Quantification of Drusen in Fundus and Optical Coherence Tomography Images for Detection of ARMD

      Automated Segmentation and Quantification of Drusen in Fundus and Optical Coherence Tomography Images for Detection of ARMD

      Age-related macular degeneration (ARMD) is one of the most common retinal syndromes that occurs in elderly people. Different eye testing techniques such as fundus photography and optical coherence tomography (OCT) are used to clinically examine the ARMD-affected patients. Many researchers have worked on detecting ARMD from fundus images, few of them also worked on detecting ARMD from OCT images. However, there are only few systems that establish the correspondence between fundus and OCT images to give an accurate prediction of ARMD pathology. In this paper, we present fully automated decision support system that can automatically detect ARMD by establishing correspondence ...

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    4. High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates

      High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates

      We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz = 834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 µm axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 ...

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    5. Billions of dollars saved with eye imaging technology co-invented by OHSU physician

      Billions of dollars saved with eye imaging technology co-invented by OHSU physician

      A non-invasive imaging technology used to evaluate eye health has saved the U.S. government and patients billions of dollars, a new study reveals. Medicare and its patients saved a combined $11.2 billion between 2008 and 2015 by using optical coherence tomography , also known as OCT, according to a paper published in the American Journal of Ophthalmology . The cost savings are a result of physicians being able to provide personalized care by using OCT scans to decide how often prescription injections are needed to treat eyes with advanced forms of macular degeneration. This often leads to reduced number of ...

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    6. Visible-light optical coherence tomography: a review

      Visible-light optical coherence tomography: a review

      Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a summary of the development of vis-OCT and its demonstrated applications. We also provide perspectives on future technology improvement and applications.

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    7. Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography

      Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography

      In their latest publication on retinal pulse wave velocity measurement using optical co-herence tomography (OCT), Qian Li et al. propose a method to determine the pulse wave velocity in retinal arteries and veins [1]. This should enable a non-invasive determination of biomechanical properties of the vessel network, particularly the elasticity of the vessel walls [2].

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    8. Early Cancer Detection (Book Chapter)

      Early Cancer Detection (Book Chapter)

      Lung cancer is the leading cause of cancer deaths worldwide as the majority of patient shave advanced disease at diagnosis.  Detection and early treatment of pre-invasive and minimally invasive lung cancer can significantly improve the current 5-year survival of <18%,  Endoscopic optical imaging (such as autoflourescence imaging), NBI, and OCT provide sensitive means to rapidly scan the central airways , in order to detect early lung cancer for biopsy confirmation and delineation of the extent of the tumor spread to guide treatment.

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    9. Broadband supercontinuum generation spanning 1.5–13 μm in Ge11.5As24Se64.5 based chalcogenide glass step index optical fiber

      Broadband supercontinuum generation spanning 1.5–13 μm in Ge11.5As24Se64.5 based chalcogenide glass step index optical fiber

      We have reported a design of a step index optical fiber in Ge 11.5 As 24 Se 64.5 chalcogenide glass. The proposed design of optical fiber is analyzed using full vectorial finite element method. The structure offers a high nonlinear coefficient of 1431 W −1  km −1 . Due to this high nonlinearity of the optical fiber a supercontinuum spectrum ranging from 1.5–13 μm is generated in only 10 mm long fiber by applying 50 fs laser secant pulses of 4000 W peak power at the pump wavelength of 3.1 μm. The use of femtosecond pulse ...

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    10. Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer

      Coronary dissection or a recanalized thrombus? Optical coherence tomography has the answer

      Intra-luminal coronary haziness during coronary angiography can be secondary to ulcerated plaque, spontaneous coronary dissection or a thrombus. During percutaneous coronary intervention, management may differ depending upon the etiology of haziness. Intravascular ultrasound and optical coherence tomography have greatly enhanced the differentiation of such intra-luminal haziness. We hereby report two cases of intra-luminal coronary haziness secondary to suspected spontaneous coronary artery dissection, which turned out to be recanalized thrombus on optical coherence tomography imaging.

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    11. Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

      Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

      Background/Aims This study aimed to evaluate blood flow in the choriocapillaris in patients with Bietti crystalline dystrophy (BCD) with CYP4V2 mutations using optical coherence tomography angiography (OCTA), and to explore the parameters associated with visual function. Methods This prospective case-series study included 13 eyes of 13 consecutive patients with BCD with CYP4V2 mutations and 20 healthy eyes. Using OCTA, we obtained en face images of blood flow in the choriocapillaris. The residual choriocapillaris area on en face images in a 10°×10° macular cube was manually measured and graded according to whether the choriocapillaris remained at the subfovea. We ...

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    12. Optical coherence tomography in gynecology: a narrative review

      Optical coherence tomography in gynecology: a narrative review

      Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an overview of the existing gynecologic OCT probes, including those for combination with other diagnostic modalities, and state-of-the-art application of OCT for diagnostics of tumor and nontumor pathologies of female genitalia ...

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    13. Adaptive classifier allows enhanced flow contrast in OCT angiography using a histogram-based motion threshold and 3D Hessian analysis-based shape filtering

      Adaptive classifier allows enhanced flow contrast in OCT angiography using a histogram-based motion threshold and 3D Hessian analysis-based shape filtering

      In this Letter, we propose an adaptive digital classifier for flow contrast enhancement in optical coherence tomography angiography (OCTA). To solve the depth dependence in the initial motion-based classification, a depth-adaptive motion threshold was determined by performing a histogram analysis of an en-face image at each depth and identifying the static and dynamic voxel populations through fitting. In the follow-up shape-based classification, to adapt to the deformed vessel shapes in OCTA, a modified vesselness function along with an anisotropic Gaussian probe kernel was defined, and then a three-dimensional (3D) Hessian analysis-based shape filtering was utilized for effectively removing the residual ...

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    14. Broadband rotary joint for high-speed ultrahigh-resolution endoscopic OCT imaging at 800  nm

      Broadband rotary joint for high-speed ultrahigh-resolution endoscopic OCT imaging at 800  nm

      We report the development of a broadband rotary joint for high-speed ultrahigh-resolution endoscopic optical coherence tomography (OCT) imaging in the 800 nm spectral range. This rotary joint features a pair of achromatic doublets in order to achieve broadband operation for a 3 dB bandwidth over 150 nm. The measured one-way throughput of the rotary joint is greater than 80%, while the fluctuation of the double-pass coupling efficiency during 360 deg rotation is less than ± 5 % ±5% at a near video-rate speed of 20 revolutions/s (rps). The rotary joint is used in conjunction with a diffractive-optics-based endoscope and 800 nm ...

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    15. Phenotypic Characterization of Corneal Endothelial Dystrophy in German Shorthaired and Wirehaired Pointers Using In Vivo Advanced Corneal Imaging and Histopathology

      Phenotypic Characterization of Corneal Endothelial Dystrophy in German Shorthaired and Wirehaired Pointers Using In Vivo Advanced Corneal Imaging and Histopathology

      Purpose: To evaluate corneal morphology using ultrasonic pachymetry (USP), Fourier-domain optical coherence tomography (FD-OCT), and in vivo confocal microscopy (IVCM) in 2 related canine breeds—German shorthaired pointers (GSHPs) and German wirehaired pointers (GWHPs)—with and without corneal endothelial dystrophy (CED). This condition is characterized by premature endothelial cell degeneration leading to concomitant corneal edema and is similar to Fuchs endothelial corneal dystrophy. Methods: Corneas of 10 CED-affected (4 GSHP and 6 GWHP) and 19 unaffected, age-matched (15 GSHP and 4 GWHP) dogs were examined using USP, FD-OCT, and IVCM. A 2-sample t test or Mann–Whitney rank-sum test was ...

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      Mentions: UC Davis
    16. Small Hyperreflective Intraretinal Material Observable on Spectral-Domain Optical Coherence Tomography in High Myopia

      Small Hyperreflective Intraretinal Material Observable on Spectral-Domain Optical Coherence Tomography in High Myopia

      With the rapid adoption of spectraldomain optical coherence tomography (SD-OCT) in clinical practice and recent advances in technology, SD-OCT has become an important tool for detecting and managing retinal pathology. The diagnosis of degenerative changes in pathologic myopia can sometimes be difficult and delayed, as the clinical presentation may be subtle. In this series, SD-OCT proved useful in the detection of small hyperreflective intraretinal material in cases in which retinal changes are minimally visible and may explain visual changes that may not have been otherwise elucidated. The results show that SDOCT in conjunction with clinical examination may provide useful information ...

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    17. Image-guided recording system for spatial and temporal mapping of neuronal activities in brain slice

      Image-guided recording system for spatial and temporal mapping of neuronal activities in brain slice

      In this study, we introduce the novel image-guided recording system (IGRS) for efficient interpretation of neuronal activities in the brain slice. IGRS is designed to combine microelectrode array (MEA) and optical coherence tomography at the customized upright microscope. It allows to record multi-site neuronal signals and image the volumetric brain anatomy in a single body configuration. For convenient interconnection between a brain image and neuronal signals, we developed the automatic mapping protocol which enables for projecting acquired neuronal signals on a brain image. In order to evaluate the performance of IGRS, hippocampal signals of the brain slice were monitored, and ...

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    18. Imaging of the lamina cribrosa and its role in glaucoma: a review

      Imaging of the lamina cribrosa and its role in glaucoma: a review

      The lamina cribrosa of the optic nerve head serves two contrasting roles; it must be porous to allow retinal ganglion cell axons to pass through, and yet at the same time, it must also provide adequate structural support to withstand the stresses and strains across it. Improvements in imaging such as optical coherence tomography image capture and image processing have allowed detailed in vivo studies of lamina cribrosa macro- and micro-architectural characteristics. This has aided our understanding of the optic nerve head as a complex biomechanical structure. In this review, we first aim to frame the biomechanical considerations of lamina ...

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    19. Spending Money to Save Money on Patient Care—The Development of Ocular Coherence Tomography

      Spending Money to Save Money on Patient Care—The Development of Ocular Coherence Tomography

      The rising costs of medical care affect individuals' insurance coverage, shape the medical plans offered by companies, and challenge national policymakers. Several factors drive inflation, including the development and application of potent pharmaceuticals, interventional technologies, and advanced imaging. Ophthalmology patients have benefited tremendously from the novel application of new laser technologies, improved phacoemulsification machines, advanced intraocular lenses, and minimally invasive glaucoma surgery.

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    20. Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Purpose To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Design Observational cohort study. Methods Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT imaging (92134), and anti–vascular endothelial growth factor (anti-VEGF) treatment–specific J-codes (J0178, J2778, J9035, J3490, and J3590). These claims were identified from the Medicare Provider Utilization and Payment Data ...

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    21. New Study Finds Federally-Funded Technology Saved Medicare $9 Billion

      New Study Finds Federally-Funded Technology Saved Medicare $9 Billion

      A new study quantifying a 21-fold return on investment suggests an efficient — and non-partisan — method to cut healthcare spending is to invest in basic research. The paper tracks how a new technology aids doctors in reducing the number of unnecessary drug injections used to treat a blinding condition called wet age-related macular degeneration (AMD). According to the study, Medicare has enjoyed $9 billion in savings over an eight year period from more efficient use of the effective, but expensive, anti-vascular endothelial growth factor (anti-VEGF) agents used to treat wet AMD. This compares favorably to the approximately $400 million investment over ...

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    22. PhD Position in Advanced Ophthalmic Imaging at Indiana University

      PhD Position in Advanced Ophthalmic Imaging at Indiana University

      A PhD student position is available in Don Miller’s laboratory on advanced ophthalmic imaging at Indiana University ( www.opt.indiana.edu/dtmiller/Index.aspx ). The laboratory is looking for a highly motivated student in engineering, optical physics, or a related discipline with an interest to develop cutting-edge optical instrumentation to study noninvasively the retina at the cellular level. The laboratory’s primary focus is on the development and use of adaptive optics and optical coherence tomography (AO-OCT) for high-resolution retinal imaging, technologies the laboratory has been advancing for almost two decades. Our most recent work can be found in ...

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