1. All Articles

    25-48 of 14167 « 1 2 3 4 5 ... 589 590 591 »
    1. Optical Coherence Tomography-guided Bifurcation Stenting of a Coronary Artery Dissection

      Optical Coherence Tomography-guided Bifurcation Stenting of a Coronary Artery Dissection

      Periprocedural guide-wire induced coronary artery dissection is a rare but potentially serious complication of PCI. Immediate stenting of the entry point is one of the therapeutic options but engaging the guide-wire in the true lumen may be challenging. We report a case of a 55-year-old woman with a guide-wire induced coronary dissection that occurred during treatment of a bifurcation lesion. Optical coherence tomography was instrumental to distinguish true form false lumen and thereby guide correct positioning of the guide-wire to successfully treat the lesion using a dedicated bifurcation stent.

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    2. Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Purpose: Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by spectral-domain optical coherence tomography (SD-OCT), and to evaluate the change in the axial diameter of retinal diabetic microaneurysms following treatment. Methods: A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following ...

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    3. Hyperreflective Pyramidal Structures on Optical Coherence Tomography in Geographic Atrophy Areas

      Hyperreflective Pyramidal Structures on Optical Coherence Tomography in Geographic Atrophy Areas

      Purpose: We observed hyperreflective dome-shaped or pyramidal structures (HPS) on spectral domain optical coherence tomography (SD-OCT) in patients affected with geographic atrophy (GA). Our purpose was to describe the multimodal imaging features of HPS identified in areas of GA in patients with age-related macular degeneration. Methods: This is a retrospective case series of patients with GA harboring HPS in atrophic areas. Multimodal imaging examination including infrared reflectance, fundus autofluorescence, and SD-OCT, was performed for each patient. Infrared and fundus autofluorescence appearance and mean SD-OCT height of HPS in GA were analyzed. Results: A total of 36 eyes of 25 patients ...

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    4. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...

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    5. Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

      Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

      Purpose To report the observation of hyper-reflective dots in the vitreous cavity using spectral domain optical coherence tomography (SD-OCT) after uneventful phacoemulsification cataract surgery and to investigate their association with cystoid macular edema (CME). Materials and Methods Medical records of consecutive Asian patients who had no preoperative retinopathy and underwent uneventful phacoemulsification cataract surgery from March 2012 through February 2013 were reviewed. SD-OCTs were performed before, 1 week, and 1 month after surgery. The number of vitreous hyper-reflective dots (VHDs) was counted in 5 OCT images of high-definition 5-line raster scans. The development of CME was assessed using postoperative 1-month ...

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    6. High Power Laser Sources At Exotic Wavelengths

      High Power Laser Sources At Exotic Wavelengths

      High power laser sources at exotic wavelengths may be a step closer as researchers in China report a fibre optic parametric oscillator with record breaking efficiency. The research team believe this could lead to new light sources for a range of biomedical imaging applications. Mature commercial laser platforms are available for common output wavelengths. Some applications, however, require wavelengths that cannot readily be produced with established technologies. Several of these are in the field of biomedical imaging and spectroscopy (e.g. coherent anti-Stokes Raman scattering microscopy and optical coherence tomography). In such systems if the wavelength of light used can ...

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    7. Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system

      Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system

      To quantitatively approach the relationship between optical changes in an accommodated eye and the geometrical deformation of its crystalline lens, a long scan-depth anterior segment OCT equipped wavefront sensor was developed and integrated with a Badal system. With this system, accommodation was stimulated up to 6.0D in the left eye and also measured in the same eye for three subjects. High correlations between the accommodative responses of refractive power and the radius of the anterior lens surface were found for the three subjects (r>0.98). The change in spherical aberration was also highly correlated with the change in ...

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    8. Advancing OCT Algorithmic Standardization

      Advancing OCT Algorithmic Standardization

      Neovascular exudative AMD (wet AMD) continues to rank as a top reason to visit eye care specialists, and the early identification of this disease has important prognostic implications for patients. 1 Advancements in optical coherence tomography (OCT) imaging have surpassed other modalities in the ability to detect the earliest development of wet AMD and prompt treatment initiation, in spite of lack of inter- and intradevice standardization. 2 , 3 Zhang et al. 4 present a novel, automated way to detect changes at the border where choroidal neovascularization (CNV) first affects the retina. They use a technique that presents an automated method ...

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    9. Phase correction using programmable phase modulator (PPM) in optical coherence tomography

      Phase correction using programmable phase modulator (PPM) in optical coherence tomography

      Purpose Adaptive optics is used in optical coherence tomography (OCT) in order to improve lateral resolution based on aberration correction. Methods Experiments were performed to compensate higher order aberrations based on wavefront sensing and correction scheme using adaptive optics. The device utilized for compensation is parallel-aligned nematic liquid crystal spatial light modulator (PAL-SLM), PPM X7550 series. Wavefront of light at the sample path was measured by using OCT for aberration correction. Since the phase information can be obtained from interferogram therefore no additional optics is used. The performance of this device is evaluated for the correction of linear tilt aberration ...

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    10. Full-range Fourier domain Doppler optical coherence tomography based on sinusoidal phase modulation

      Full-range Fourier domain Doppler optical coherence tomography based on sinusoidal phase modulation

      A novel full-range Fourier domain Doppler optical coherence tomography (full-range FD-DOCT) using sinusoidal phase modulation for B-M scan is proposed. In this sinusoidal B-M scan, zero optical path difference (OPD) position does not move corresponding to lateral scanning points in contrast to linear B-M scan. Since high phase sensitivity arises around the zero OPD position, the proposed full-range FD-DOCT can achieve easily high velocity sensitivity without mirror image around the zero OPD position. Velocity sensitivity dependent on the OPD and the interval of scanning points is examined, and flow velocity detection capability is verified through Doppler imaging of a flow ...

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    11. Virtual reality simulator for vitreoretinal surgery using integrated OCT data

      Virtual reality simulator for vitreoretinal surgery using integrated OCT data

      Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT) scans from real patients for practicing vitreoretinal surgery using different pathologic scenarios.

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      Mentions: Igor Kozak
    12. Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      PurposeTo describe the characteristic optical coherence tomography (OCT) findings of the iris in Cogan-Reese syndrome.MethodsA 63-year-old woman was referred for consultation due to diffuse pigmentation of the iris and elevated intraocular pressure (IOP) in the left eye. The clinical examination revealed Cogan-Reese syndrome with pedunculated iris outcroppings on the entire iris surface, and no peripheral anterior synechia. The right eye was normal with normal IOP.ResultsImaging the left iris with the CAM-L cornea lens adapter of the Optovue Fourier-domain OCT (RTVue-OCT) showed a folded iris surface, an increased total iris thickness, and an increased distance between the anterior and ...

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    13. Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography

      Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography

      PurposeTo measure choroidal thickness in patients with pseudoexfoliation (PEX) syndrome and to compare the values with control eyes using enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThirty-four patients with PEX syndrome and 30 age- and sex-matched healthy subjects were included in this study. Only one eye of each of the patients was included. Choroidal thickness was measured manually from the outer border of the retinal pigment epithelium to the inner scleral border at the subfovea, 3 mm temporal to the fovea, and 3 mm nasal to the fovea using EDI-OCT.ResultsA total of 34 eyes from 34 consecutive patients with ...

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    14. Assessment of early occlusal caries pre- and post- sealant application—An imaging approach

      Assessment of early occlusal caries pre- and post- sealant application—An imaging approach

      Background and Objective Clinicians have difficulty assessing and monitoring early occlusal caries. Traditional clinical exam and radiographs are unable to detect the subtle alterations in enamel indicative of de- or re-mineralization, particularly under dental sealants. Although clinicians have used laser fluorescence (LF) to address this gap, this modality has demonstrated weak correlation with histology. The International Caries Detection and Assessment System (ICDAS-II) has demonstrated high sensitivity and specificity for caries detection, but since it is based on visual assessment, it is of no use in areas beneath the most commonly used dental sealants which are opaque. Optical coherence tomography (OCT ...

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    15. Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography

      Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography

      Purpose to distinguish differences in retinal nerve fiber layer (RNFL) thickness and peripapillary total retinal volume between eyes with papilledema, pseudopapilledema, and normal findings. Design Cohort study Methods Forty-two eyes with mild papilledema, 37 eyes with congenitally elevated optic disc (pseudopapilledema), and 34 normal eyes met the inclusion criteria at 1 academic institution (in Iran) and underwent neuro-ophthalmic examination. Spectral-domain optical coherence tomography scans surrounding the optic disc were performed in each eye of patients and subjects. Main outcome measures were mean RNFL thickness and peripapillary total retinal volume measurements (inner and outer rings volumes) that were compared between groups ...

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    16. In vivo analysis of the iris thickness by spectral domain optical coherence tomography

      In vivo analysis of the iris thickness by spectral domain optical coherence tomography

      Purpose To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods 14 healthy volunteers and 14 patients with unilateral Fuchs’ uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators ...

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    17. Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Second-degree scalding is a common dermatological injury. Inappropriate treatment methods in clinical practice always produce scarring, and can lead to skin cancer and other complications in the longer term. In this study optical coherence tomography (OCT) combined with a skin detector was used to monitor the response of second-degree scalded skin tissue irradiated by a CO2 laser. The process of treatment of second-degree scalding was systematically studied from the perspective of tissue optics. The OCT signal intensity was stronger within the whole recovery period in the experimental group undergoing CO2 laser treatment, and the attenuation coefficient (μt) returned ...

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    18. Cornea characterization using a combined multiphoton microscopy and optical coherence tomography system

      Cornea characterization using a combined multiphoton microscopy and optical coherence tomography system

      We present a multimodal imaging system which combines multiphoton microscopy and optical coherence tomography to visualize the morphological structures, and to quantify the refractive index (RI) and thickness of cornea. The morphological similarities and differences at different corneal layers across various species are identified. In the piscine and human corneas, the stromata exhibit thin fibers that indicate an overall collagen direction. Human corneas display collagen micro-folds which cause increased light attenuation. In the murine, porcine and bovine corneas, the stromata show interwoven collagen patterns. The Bowman’s layer and the Descemet’s membrane are also distinguished in some species. The ...

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    19. Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views

      Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views

      This video (, available online at www.giejournal.org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett's esophagus.

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      Mentions: FDA
    20. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Purpose of Review To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to ischemia of the retinal deep capillary plexus (DCP). Recent Findings With the advent of high-definition SD-OCT imaging, we are now able to detect deep capillary ischemia. Although cotton wool spots are caused by ischemia of the superficial capillary plexus, PAMM is caused by ischemia of the DCP, and appears as hyper-reflective, band-like lesions in the middle retina, extending from the ...

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    21. Feature Of The Week 4/13/14: Growth Kinetics of Concave Nanocubes Studied by Optical Coherence Tomography

      Feature Of The Week 4/13/14: Growth Kinetics of Concave Nanocubes Studied by Optical Coherence Tomography

      This work presents the analysis of the growth kinetics of two syntheses of concave gold nanocubes with a mean size of 72 and 108 nm followed by the optical coherence tomography (OCT) technique by acquiring B-scan images each 5 s. In addition, ultra violet-visible (UV-Vis) spectra and mean size from dynamic light scattering (DLS) were acquired during nanoparticle growth to generate kinetic plots in order to corroborate the OCT results. Kinetic plots from OCT images were obtained by plotting contrast enhancement of B-scan images as function of time. Fitting parameters values given by using the classical Kolmogorov-Johnson-Mehl-Avrami (KJMA) equation show ...

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    22. Label-free cell-based assay with spectral-domain optical coherence phase microscopy

      Label-free cell-based assay with spectral-domain optical coherence phase microscopy

      Quantitative measurement of dynamic responses of unstained living cells is of great importance in many applications ranging from investigation of fundamental cellular functions to drug discoveries. Conventional optical methods for label-free cell-based assay examine cellular structural changes proximal to sensor surfaces under external stimuli, but require dedicated nanostructure-patterned substrates for operation. Here, we present a quantitative imaging method, spectral-domain optical coherence phase microscopy (SD-OCPM), as a viable optical platform for label-free cell-based assay. The instrument is based on a low-coherence interferometric microscope that enables quantitative depth-resolved phase measurement of a transparent specimen with high phase stability. We demonstrate SD-OCPM measurement ...

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    23. Optical coherence tomography and visual evoked potentials in healthy persons

      Optical coherence tomography and visual evoked potentials in healthy persons

      Purpose Optical coherence tomography (OCT) and Visual evoked potentials (VEPs) represent non-invasive objective examination of the visual system. While the OCT measures a morphological property of the retina (thickness of the retinal nerve fibre layer – RNFL), the VEP allows assessment a function of the visual system. There are numerous studies describing a mutual involvement of both mentioned aspects in diseases like multiple sclerosis, optic neuritis or glaucoma, however, normative studies of these relationship are missing. In our study we address this issue with an expectation to translate the findings into interpretation of pathological findings. Methods We examined a group of ...

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    24. Structure-Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time Domain and Spectral Domain OCT devices

      Structure-Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time Domain and Spectral Domain OCT devices

      Purpose: To examine the structure-function relationship between two perimetric tests, the Frequency-Doubling Technology (FDT) Matrix and Standard Automated Perimetry (SAP), and two Optical Coherence Tomography (OCT) devices (Time-Domain and Spectral-Domain). Methods: This cross-sectional study included 97 eyes from 29 healthy individuals and 68 individuals with early, moderate, or advanced primary open-angle glaucoma. The correlations between overall and sectorial parameters of retinal nerve fiber layer thickness (RNFL) measured with Stratus and Spectralis OCT and the visual field sensitivity obtained with FDT Matrix and SAP were assessed. The relationship was also evaluated using a previously described linear model. Results: The correlation coefficients ...

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