1. All Articles

    25-48 of 15634 « 1 2 3 4 5 ... 650 651 652 »
    1. Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Evaluation of burn severity is a significant clinical problem with over 2 million burns reported each year in the United States [1]. The magnitude of this clinical need has inspired the development of many technologies to assess burn depth, but none of these have been widely adopted as clinical judgment still relies primarily on visual inspection, with an accuracy of about 70% [2]. A recent study by researchers at Duke University used spectroscopic optical coherence tomography (OCT) to evaluate burned animal tissues in vivo. Spectroscopic OCT is an extension of conventional OCT that can measure depth-resolved scattering and absorption spectra ...

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    2. Multiple Simultaneous Plaque Erosion in 3 Coronary Arteries

      Multiple Simultaneous Plaque Erosion in 3 Coronary Arteries

      We performed optical coherence tomography (OCT) imaging with matched histology in a 34-year-old man with history of smoking and untreated hyperlipidemia who had suffered from epigastric pain and was found dead at home. Multiple plaque erosions in 3 major coronary arteries were discovered (Figure 1 )

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    3. Automatic quantification of intravascular optical coherence tomography (Thesis)

      Automatic quantification of intravascular optical coherence tomography (Thesis)

      As mentioned above, IVOCT, as a novel imaging modality, has played an active role in a wide range of CAD applications, including research and clinical routine. Due to its unparalleled high resolution and the ability to delineate complex vascular structures, IVOCT technology makes many precise measurement and novel applications possible. However, currently, a lot of analyses in IVOCT images are still relying on the manual work which decreases their value. The goal of this thesis is to develop robust and accurate (semi)automated methods that can detect and segment the interesting components in IVOCT pullback runs, such as implanted stent ...

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    4. The cross-correlation in spectral domain based Doppler optical coherence tomography

      The cross-correlation in spectral domain based Doppler optical coherence tomography

      We propose a cross-correlation method which is based on the cross-correlation of two adjacent A-scans of interferogram fringe for imaging the velocities of the blood flowing in vessels. The method was tested by measurements of the velocities of flowing particles within a glass capillary with known mean velocities. Mean standard deviations of flow velocities of the particles determined through the proposed method were compared to those by the conventional phase resolved method. I n vivo imaging of a mouse ear was performed and the Doppler flow velocity maps were reconstructed by both methods. The experimental results demonstrated that the proposed ...

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    5. Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)

      Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)

      Although our knowledge of neuronal function and regional activity has been tremendously enriched in the past decades, coordination of these neurons to form the complex behaviors has yet to be understood. The neuronal pathways (also named connectome) form the structural foundation of the dynamic circuits in the brain. The recent interests in connectome and brainwide database have imposed a pressing need for high-resolution imaging techniques that allows large coverage. This dissertation develops a novel multi-contrast optical coherence tomography (MC-OCT) technique for the application of brainwide imaging and architectural mapping in 3D at high spatiotemporal resolution, with an emphasis on the ...

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    6. Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence

      Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence

      Background : “ Poppers ” is a slang term for a group of alkyl nitrites that are used as recreational drugs . Their inhalative intoxication leads to muscle relaxation, analgesia, and euphoria. Maculopathy is a rare but serious side-effect. Patients/Methods : Clinical, imaging, and electrophysiological findings of seven patients with maculopathy after consumption of poppers were presented. Results : All seven patients were male with a median age of 35 years (range 28–45 years), the median duration of periodical poppers use until the onset of symptoms was 9.8 years (one day to 25 years). Five of seven patients were HIV-positive, one patient was ...

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    7. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

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    8. Morphological phenotyping of mouse hearts using optical coherence tomography

      Morphological phenotyping of mouse hearts using optical coherence tomography

      Transgenic mouse models have been instrumental in the elucidation of the molecular mechanisms behind many genetically based cardiovascular diseases such as Marfan syndrome (MFS). However, the characterization of their cardiac morphology has been hampered by the small size of the mouse heart. In this report, we adapted optical coherence tomography (OCT) for imaging fixed adult mouse hearts, and applied tools from computational anatomy to perform morphometric analyses. The hearts were first optically cleared and imaged from multiple perspectives. The acquired volumes were then corrected for refractive distortions, and registered and stitched together to form a single, high-resolution OCT volume of ...

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    9. Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging

      Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging

      We demonstrate an all-fiber breathing laser as inertia-free swept source (BLISS), with an ultra-compact design, for the emerging ultrafast bioimaging modalities. The unique feature of BLISS is its broadband wavelength-swept operation ( ∼ 60     nm ) with superior temporal stability in terms of both long term (0.08 dB over 27 h) and shot-to-shot power variations (2.1%). More importantly, it enables a wavelength sweep rate of > 10     MHz ( ∼ 7 × 10 8     nm / s )—orders-of-magnitude faster than the existing swept sources based on mechanical or electrical tuning techniques. BLISS thus represents a practical and new generation of swept source operating in the unmet ...

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    10. Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK

      Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK

      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. Send us your talk and poster abstracts! Topics include, but are not limited to: Clinical applications of OCT (e.g. ophthalmology, cardiology, dermatology) Industrial applications of OCT (e.g. nondestructive testing) Life science applications in OCT (e.g. cell biology, tissue engineering) Multimodal applications including OCT (e.g. combination of fluorescence, Raman and OCT) Biophotonics themes ...

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    11. Coherence improvement in dispersion-tuned swept laser by pulse modulation

      Coherence improvement in dispersion-tuned swept laser by pulse modulation

      The dispersion-tuned swept laser (DTSL) is a fast and wideband swept source applicable in swept-source optical coherence tomography (SS-OCT). However, it suffers from coherence degradation at high sweep rates. The coherence in the DTSL, which can be improved by pulse modulation in place of sinusoidal modulation, is demonstrated. A coherence length of 8 mm is obtained at a sweep rate of 50 kHz using 100 ps pulse modulation.

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    12. Noise characterization of supercontinuum sources for low-coherence interferometry applications

      Noise characterization of supercontinuum sources for low-coherence interferometry applications

      We examine the noise properties of supercontinuum light sources when used in low-coherence interferometry applications. The first application is a multiple-scattering low-coherence interferometry (ms2/LCI) system, where high power and long image acquisition times are required to image deep into tissue. For this system, we compare the noise characteristics of two supercontinuum sources from different suppliers. Both sources have long-term drift that limits the amount of time over which signal averaging is advantageous for reducing noise. The second application is a high-resolution optical coherence tomography system, where broadband light is needed for high axial resolution. For this system, we compare ...

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    13. A New OCT-based Method to Generate Virtual Maps of Vitreomacular Interface Pathologies

      A New OCT-based Method to Generate Virtual Maps  of Vitreomacular Interface Pathologies

      Optical coherence tomography (OCT) is the most accurate modality for noninvasive assessment of vitreoretinal interface (VRI). The scientific objective of research presented in this paper was to develop a new OCT-based method for investigation of vitreomacular interface pathologies in human eyes. We propose a new approach for the automatic generation of virtual maps representing the distance between the posterior surface of the hyaloid (PSH) and the inner limiting membrane (ILM) in the vitreomacular traction (VMT) pathology. Volumetric data was acquired from 3 adult patients with VMT. OCT B-scans were processed frame-by-frame and refined by advanced digital imaging algorithms, including application ...

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    14. Perspectives on Imaging the Left Main Coronary Artery Using Intravascular Ultrasound and Optical Coherence Tomography

      Perspectives on Imaging the Left Main Coronary Artery Using Intravascular Ultrasound and Optical Coherence Tomography

      Percutaneous Coronary Intervention (PCI) for significant left main coronary artery (LMCA) stenosis is increasingly being viewed as a viable alternative to Coronary Artery Bypass Grafting (CABG) (1). This is leading to an expectation of increasing numbers of such procedures, with a consequent focus on both the ability to image both lesion severity, and assess more accurately the results of PCI. While there have been advances in physiologic assessment of left main severity using fractional flow reserve (FFR), imaging of the LMCA using Intravascular Ultrasound (IVUS) and more recently Optical Coherence Tomography (OCT) has the specific advantage of being able to ...

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    15. Composition Imaging System for Intravascular Optical Coherence Tomography “Compovision-OCT”

      Composition Imaging System for Intravascular Optical Coherence Tomography “Compovision-OCT”

      We have developed an optical coherence tomography system, Compovision-OCT (CV-OCT) that detects lipid for intravascular diagnosis. This system is developed by combining our proprietary Compovision technology, which visualizes the composition of the object using near-infrared light, and optical coherence tomography, which visualizes the cross-sectional tomographic image of the object using interference of light. The main feature of CV-OCT is that it utilizes the near-infrared light in the 1.7 µm wavelength band, which shows an absorption peak of lipid contained in coronary artery plaque. To achieve a performance needed in clinical applications, this system employs a broadband light source based ...

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    16. Glaucoma Module Premium Edition for SPECTRALIS to be Showcased at Annual Optometric Press Conference

      Glaucoma Module Premium Edition for SPECTRALIS to be Showcased at Annual Optometric Press Conference

      Heidelberg Engineering GmbH, the global ophthalmic imaging company, is presenting the Glaucoma Module Premium Edition for SPECTRALIS at the annual 2014 American Academy of Optometry Professional Press Conference in Denver, CO. The Glaucoma Module Premium Edition for SPECTRALIS* module combines a proprietary technology called Anatomic Positioning System (APS) with a series of unique scan patterns. The APS creates an anatomic map of each eye. The center of the optic nerve head and the fovea are detected via a short pre-scan function. The map is aligned according to these anatomical landmarks, individually for each eye. Subsequent scans are oriented to this ...

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    17. Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography

      Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography

      A microscope-based optical coherence tomography (OCT) device was used to assess the microanatomy of the tympanic membrane in patients with chronic myringitis. A prospective study was designed for this purpose. OCT measurements of the tympanic membrane were done on 11 patients with myringitis with a microscope-based spectral domain OCT system. The in vivo findings were compared with those findings of a control group consisting of 36 patients with retraction pockets or atrophic tympanic membranes ( n = 13), myringosclerosis ( n = 12) and perforations ( n = 11). In active chronic myringitis, the thickness of the tympanic membrane is increased compared to healthy membranes and ...

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    18. Heidelberg training attracts a crowd

      Heidelberg training attracts a crowd

      Heidelberg Engineering has reported that 300 UK eye care professionals have now completed OCT training for its Spectralis instrument. The next training events were to be held at the Heidelberg Engineering Academy in Hemel Hempstead on November 28 and then December 3. ‘We have now fine-tuned the courses to suit our audiences of small groups of people – all with a similar level of optometric knowledge,’ said Christopher Mody, clinical programme manager of Heidelberg.

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    19. Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

      Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

      We accomplished spectral domain optical coherence tomography and auto-fluorescence microscopy for imaging the retina with a single broadband light source centered at 480 nm. This technique is able to provide simultaneous structural imaging and lipofuscin molecular contrast of the retina. Since the two imaging modalities are provided by the same group of photons, their images are intrinsically registered. To test the capabilities of the technique we periodically imaged the retinas of the same rats for four weeks. The images successfully demonstrated lipofuscin accumulation in the retinal pigment epithelium with aging. The experimental results showed that the dual-modal imaging system can ...

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    20. Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Macrophages and intravascular optical coherence tomography bright spots: a quantitative study

      Objectives We hypothesized that bright spots in intravascular optical coherence tomography (IVOCT) images may originate by co-localization of plaque materials of differing indices of refraction (IR). To quantitatively identify bright spots, we developed an algorithm that accounts for factors including tissue depth, distance from light source, and signal-to-noise ratio. We used this algorithm to perform a bright spot analysis of IVOCT images, and compared these results with histologic examination of matching tissue sections. Background Although bright spots are thought to represent macrophages in IVOCT images, studies of alternative etiologies have not been reported. Methods Fresh human coronary arteries (n=14 ...

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    21. Contrast enhancement using Mie spectra representation for spectroscopic optical coherence tomography

      Contrast enhancement using Mie spectra representation for spectroscopic optical coherence tomography

      The paper presents a spectroscopic optical coherence tomography (SOCT) method that offers a tomography imaging contrast in scatterer size. In the method, the depth resolved spectroscopy is modelled as a linear combination of basis spectra from scatterers in a prescribed dictionary. The depth resolved spectroscopy is first reconstructed by searching the optimal expansion of the SOCT spectral measurement over the basis spectra. Then the scatterer sizes corresponding to the spectra in the optimal expansion are used to display the SOCT image. Simulation and experimental studies demonstrated that the proposed contrast can differentiate the scatterer clusters in samples.

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    22. Optical coherence tomography in the 2um wavelength regime for paint and other high opacity materials

      Optical coherence tomography in the 2um wavelength regime for paint and other high opacity materials

      An optical coherence tomography system using a compact fiber source emitting amplified spontaneous emission at central wavelength of 1960 nm with bandwidth of 40 nm is developed to enhance the probing depth in a highly scattering material with low water content. Examples of application to paint are used to demonstrate significantly improved penetration depth in high opacity materials in the 2-μm wavelength regime.

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    23. Endoscope employs custom camera for in-vivo cancer detection

      Endoscope employs custom camera for in-vivo cancer detection

      Early cancer detection is often performed by removing tissue from a patient during a biopsy procedure and then examining the cell structure under a microscope. Identifying which tissue to be removed, however, is not an exact science and patients often need to return for a second biopsy. Since this procedure is both painful and expensive, the ability to ensure the correct tissue is removed speeds the diagnostic procedure while reducing patient stress and expense. To increase the certainty of obtaining cancerous tissue, LLTech (Paris, France; www.lltechimaging.com) is developing a hand-held rigid endoscope that provides surgeons and pathologists to ...

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    25-48 of 15634 « 1 2 3 4 5 ... 650 651 652 »
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