1. All Articles

    25-48 of 19206 « 1 2 3 4 5 ... 799 800 801 »
    1. Objective Evaluation of Functionality of Filtering Bleb Based on Polarization-Sensitive Optical Coherence Tomography

      Objective Evaluation of Functionality of Filtering Bleb Based on Polarization-Sensitive Optical Coherence Tomography

      Purpose : The fibrosis score is a new diagnostic score that we have developed to evaluate the function of bleb structures after glaucoma filtration surgery using polarization-sensitive optical coherence tomography (PS-OCT). This study aims to assess the efficacy of the fibrosis score in discriminating nonfunctional from the functional blebs. Methods : A total of 20 patients who had undergone glaucoma filtration surgery were imaged at different time periods after surgery using PS-OCT. Birefringence tomography of blebs was obtained from PS-OCT, and the fibrosis score was computed for each patient. The fibrosis score is defined as the area of occupation of high birefringence ...

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    2. Optical Coherence Tomography: A Potential Noninvasive Follow-up Tool in Multiple Sclerosis

      Optical Coherence Tomography: A Potential Noninvasive Follow-up Tool in Multiple Sclerosis

      Physicians have been struggling to objectively monitor the disease progression in multiple sclerosis (MS). There have been conflicting reports of significant reduction in retinal ganglion cell layer (RGC) and retinal nerve fiber layer (RNFL) loss in patients with MS. 1 , 2 Loss of RGC and RNFL has been associated with disease-related visual deterioration and general disability and brain atrophy. 3 The longitudinal study by Graham et al . 4 about progressive loss of retinal ganglion cells and axons in fellow eyes of patients with relapsing–remitting MS with optic neuritis can provide substantial grounds for application of optical coherence tomography (OCT ...

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    3. In vivo thickness dynamics measurement of tear film lipid and aqueous layers with optical coherence tomography and maximum-likelihood estimation

      In vivo thickness dynamics measurement of tear film lipid and aqueous layers with optical coherence tomography and maximum-likelihood estimation

      Dry eye disease (DED) is a common ophthalmic condition that is characterized by tear film instability and leads to ocular surface discomfort and visual disturbance. Advancements in the understanding and management of this condition have been limited by our ability to study the tear film secondary to its thin structure and dynamic nature. Here, we report a technique to simultaneously estimate the thickness of both the lipid and aqueous layers of the tear film in vivo using optical coherence tomography and maximum-likelihood estimation. After a blink, the lipid layer was rapidly thickened at an average rate of 10    nm / s ...

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    4. Variability in Spectral-Domain Optical Coherence Tomography over 4 Weeks by Age

      Variability in Spectral-Domain Optical Coherence Tomography over 4 Weeks by Age

      Purpose: To quantify variation in spectral-domain optical coherence tomography (SD-OCT) measures of total retinal thickness (top of inner limiting membrane to top of retinal pigment epithelium, RPE) and RPE thickness measures over a 4-week period and by age. Methods: A total of 76 volunteers aged 40–85 years were seen at three visits over 4 weeks. Two Topcon SD-OCT scans were taken at each visit. Following grid re-centration, total retinal and RPE thickness were determined in nine subfields. Multilevel modeling was used to quantify variance between scans and by age. Results: In the central circle, mean total retinal thickness was ...

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    5. Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University

      Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University

      One research fellow position, one research associate position, and one PhD scholarship is available at School of Electrical & Electronic Engineering. The successful candidates will join a multidisciplinary team of 10 research staff and 10 PhD students and work on collaborative research projects with a focus on microscopic/endoscopic technology development and translational studies. These positions are supported by multiple active grants (Funding amount: $10M; Funding period: 2015-2020) for developing ultrahigh resolution optical coherence tomography technologies suitable for in vivo imaging of cellular structures in human organs. Requirements for research fellow: 1) A PhD’s degree in optical instrumentation, optics and ...

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    6. Enhanced Tissue Ablation Efficiency with a Mid-Infrared Nonlinear Frequency Conversion Laser System and Tissue Interaction Monitoring Using Optical Coherence Tomography

      Enhanced Tissue Ablation Efficiency with a Mid-Infrared Nonlinear Frequency Conversion Laser System and Tissue Interaction Monitoring Using Optical Coherence Tomography

      We report development of optical parametric oscillator (OPO)-based mid-infrared laser system that utilizes a periodically poled nonlinear crystal pumped by a near-infrared (NIR) laser. We obtained a mid-infrared average output of 8 W at an injection current of 20 A from a quasi-phase-matched OPO using an external cavity configuration. Laser tissue ablation efficiency is substantially affected by several parameters, including an optical fluence rate, wavelength of the laser source, and the optical properties of target tissue. Dimensions of wavelength and radiant exposure dependent tissue ablation are quantified using Fourier domain optical coherence tomography and the ablation efficiency was compared ...

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      Mentions: Dae Yu Kim
    7. Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      Purpose : To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. Methods : Forty-five consecutive RRMS patients and 20 age- and sex-matched healthy subjects were enrolled. All patients were followed up for 3 years with annual optical coherence tomography (OCT) scans, which included a peripapillary ring scan protocol for RNFL analysis and a macular radial star-like scan to obtain RGC/inner plexiform layer (IPL) thickness measures. Healthy controls were scanned ...

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    8. NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical, Inc., a transformative medical device company that is pioneering the clinical use of a real-time imaging platform based upon a proprietary optical coherence tomography (OCT) technology, announced today the appointment of John Temple as Vice President of Sales. Mr. Temple reports directly to NinePoint Medical’s President and CEO, Christopher R. von Jako, Ph.D. “We are delighted to welcome such an accomplished sales executive to the NinePoint Medical team. Not only does John bring tremendous commercial leadership experience, but also in-depth gastroenterology industry knowledge and relationships,” said Dr. von Jako. “John’s exceptional track record will be ...

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    9. VivoSight OCT used to visualize vascular networks in melanoma and non-melanoma skin cancers

      VivoSight OCT used to visualize vascular networks in melanoma and non-melanoma skin cancers

      Maidstone, UK, 3rd May 2016 New results have been published in Dermatology Online demonstrating that Michelson Diagnostics’ VivoSight OCT scanner can be used to image the blood vessel networks grown by skin cancers, and showing that skin lesions could be differentiated using their characteristic vascular patterns. This new technology may become a powerful tool in the dermatologists’s toolkit for the diagnosis of skin cancer and other conditions. The paper, entitled “Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns” was by Dr Orit Markowitz and co-workers from SUNY Downstate Medical Center, New Your Harbor ...

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    10. Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique

      Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique

      Software systems, arrangements and processes for evaluating an image associated with at least one portion of an anatomical structure are provided. For example, first information associated with the at least one portion of the anatomical structure second information associated with the at least one portion of the anatomical structure can be received. Third information can be generated by determining a relationship between the first information and the second information. Further, the image can be evaluated using a predetermined pathological scoring criteria and the third information.

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    11. Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography

      Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography

      Exemplary systems, apparatus, methods and computer-accessible medium for generating information regarding at least one sample can be provided. For example, it is possible to receiving first data which is based on at least one first radiation provided to the sample(s) and at least one second radiation provided from the sample(s) that is/are associated with the first radiation(s) It is also possible to generate second data by reducing the influence of first optical effects induced on the first radiation(s) prior to reaching the sample(s), and second optical effects induced on the second radiation(s) after ...

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    12. Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography

      Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography

      Purpose The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). Methods In a prospective, observational, cross-sectional study, glaucomatous ( n = 66) and healthy ( n = 52) eyes were examined by Spectralis OCT, HRT III and Laguna ONhE. The following Laguna ONhE variables were determined: ONH Hb across the vertical disc diameter (8&20 Hb), estimated cup–disc ratio (C/D) and the glaucoma discriminant function (GDF), which combines ...

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    13. Optical coherence tomography Layout Simulation Using MATLAB®

      Optical coherence tomography Layout Simulation Using MATLAB®

      Optical Coherence Tomography (OCT) is a non-invasive optical imaging technique capable of producing 2D images or 3D reconstructions of nonhomogeneous samples. OCT is mainly used in ophthalmology as a powerful tool for the early diagnosis of ocular diseases. With OCT it is possible to obtain high resolution cross-sectional images of ocular structures, such as the retina or the anterior segment. An OCT platform for ocular image acquisition is being developed. It is based on a swept source laser, an InGaAs balanced detector, a data acquisition board installed on a personal computer, and several optical components. The main purpose of this ...

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    14. IEEE Boston Photonics Society Talk on Swept Source Lasers by Bart Johnson

      IEEE Boston Photonics Society Talk on Swept Source Lasers by Bart Johnson

      The development of swept source lasers has made high-speed optical coherence tomography (OCT) cost effective at 1060 and 1310 nm wavelengths. Axsun Technologies manufactures this type of source and has made inroads into ophthalmology and cardiology applications. The 1060 product, for example, tunes 990-1100 nm at a 100 kHz sweep rate. This external cavity diode laser is tuned by a MEMS Fabry-Perot filter. The act of rapidly sweeping the filter induces a mode-locking behavior. This is because when the pulses deplete the gain medium they are red shifted due to the index rise in the semiconductor optical amplifier associated with ...

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    15. Author Response: Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      Author Response: Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      On behalf of the author team, we thank Hu and Ding 1 for noting our study 2 to be interesting. Hu and Ding raise pertinent questions related to reproducibility of the optical coherence tomography angiography (OCTA) images and intra- and interobserver variability. We do acknowledge that the OCTA examination can take a long time, and patient eye movement can be a confounder in any analyses. There are two issues to be considered. One is the reproducibility of the OCTA image and the other is the reproducibility of the local fractal dimension method. In the latter case, as long as the ...

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    16. Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      We read with interest the article by Gadde and colleagues 1 on quantifying vessel density and the foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images using a fully automated local fractal dimension method. The authors concluded that this novel method can calculate retinal vessel density and the FAZ area. They also contended that retinal vessel density was not correlated with age and that the inferior zone of retinal vessel density is largest in the parafoveal region. We congratulate and applaud their interesting and important work on this topic; however, we have one question for the authors ...

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      Mentions: Optovue
    17. LONG-TERM RETROSPECTIVE ANALYSIS OF VISUAL ACUITY AND OPTICAL COHERENCE TOPOGRAPHIC CHANGES AFTER SINGLE VERSUS DOUBLE PEELING DURING VITRECTOMY FOR MACULAR EPIRETINAL MEMBRANES

      LONG-TERM RETROSPECTIVE ANALYSIS OF VISUAL ACUITY AND OPTICAL COHERENCE TOPOGRAPHIC CHANGES AFTER SINGLE VERSUS DOUBLE PEELING DURING VITRECTOMY FOR MACULAR EPIRETINAL MEMBRANES

      Purpose: To determine the long-term effect of internal limiting membrane with associated epiretinal membrane (ERM) peeling versus single peeling alone in terms of best-corrected visual acuity and anatomical outcomes on spectral-domain optical coherence tomography. Methods: This retrospective comparative cohort study of patients who had follow-up of >1 year and underwent surgery for ERM by a single surgeon (S.C.) from January 1, 2008 to December 31, 2012 compared cases in which the internal limiting membrane was stained with brilliant blue G to facilitate double peeling (n = 42) and single peeling (n = 43) of the ERM alone for up to 3 ...

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    18. Calibration Phantoms for Optical Coherence Tomography at Aston University

      Calibration Phantoms for Optical Coherence Tomography at Aston University

      Calibration Phantoms for Optical Coherence Tomography Applications are invited for a three year Postgraduate studentship, supported by the School of Engineering and Applied Science, to be undertaken within the Aston Institute of Photonic Technologies at Aston University. The successful applicant will join an established experimental group working on the design and fabrication of calibration phantoms for optical coherence tomography using femtosecond laser materials processing. The studentship is offered in collaboration with Arden Photonics . The position is available to start in October 2016 (subject to negotiation) Financial Support This studentship includes a fee bursary to cover the home/EU fees rate ...

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    19. Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      We have demonstrated for the first time, to our knowledge, the use of optical coherence tomography (OCT) as an analytical tool for nondestructively characterizing the individual paint layer thickness of multiple layered automotive paints. A graph-based segmentation method was used for automatic analysis of the thickness distribution for the top layers of solid color paints. The thicknesses measured with OCT were in good agreement with the optical microscope and ultrasonic techniques that are the current standard in the automobile industry. Because of its high axial resolution (5.5 μm), the OCT technique was shown to be able to resolve the ...

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      Mentions: Yalin Zheng
    20. SS-OCT PCIe Card from Keysight Technologies

      SS-OCT PCIe Card from Keysight Technologies

      Keysight Technologies Inc. offers swept source optical coherence tomography (SS-OCT) application options for the U5303A compact, dual-channel ADC card, delivering high dynamic range and a high effective number of bits for enhanced image quality. The new options support up to 1 GS/s on the 12-bit, high-speed data acquisition peripheral component interconnect express (PCIe) card. Image acquisition is featured at a rate of 200 kHz, continuously. The real-time processing solution allows OEMs to develop SS-OCT engines using the development environment provided, which includes a graphical user interface and C++ programming language. The new options also ensure improved spurious-free dynamic range ...

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    21. Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for en face plotting. We demonstrate the efficiency of proposed additional algorithms as for the microcirculation imaging of hamsters cheek in vivo as for the preliminary microcirculation imaging of patients after ...

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    22. Optical coherence tomography angiography in pediatric choroidal neovascularization

      Optical coherence tomography angiography in pediatric choroidal neovascularization

      Purpose : To report two cases of pediatric choroidal neovascularization (CNV) and the associated neovascular and retinal findings identified on Optical Coherence Tomography Angiography (OCTA) imaging. Methods : A 14-year-old boy with handheld laser-induced maculopathy-related CNV and a 13-year-old boy with idiopathic CNV were evaluated with visual acuity testing, slit-lamp exam, fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography, and OCTA. Results : Macular CNV were identified in both pediatric patients using OCTA imaging. The first case demonstrated a classic pediatric type II CNV with a "tree-like" pattern and a single vessel in-growth site, while the second case demonstrated ...

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    23. Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      We present a case of a patient with non-ST-elevation myocardial infarction due to very late stent thrombosis, 2 years after a sirolimus-eluting stent implantation (SES). Optical coherence tomography (OCT) imaging identified vessel wall destruction of the whole stented coronary segment with multiple cavity formations along the entire stent length, severe struts malapposition and thrombi. The patient was treated successfully with the implantation of a bare metal stent (BMS). Follow-up OCT imaging at 12 months revealed improvement of vascular healing with complete re-endothelialization of the distal parts of the new BMS, while the stent body remained partly uncover suggesting vascular toxicity ...

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