1. All Articles

    25-48 of 17540 « 1 2 3 4 5 ... 729 730 731 »
    1. Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Purpose : Quantification of retinal layers using automated segmentation of optical coherence tomography (OCT) images allows for longitudinal studies of retinal and neurological disorders in mice. The purpose of this study was to compare the performance of automated retinal layer segmentation algorithms with data from manual segmentation in mice using the Spectralis OCT. Methods : Spectral domain OCT images from 55 mice from three different mouse strains were analyzed in total. The OCT scans from 22 C57Bl/6, 22 BALBc, and 11 C3A.Cg- Pde6b + Prph2 Rd2 /J mice were automatically segmented using three commercially available automated retinal segmentation algorithms and compared ...

      Read Full Article
    2. Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      The accurate observation of physiological changes on in vivo samples of important animal species such as Euphausia superba (Antarctic krill) is an important goal in helping to understand how environmental changes can affect animal development. Using a custom made ‘krill trap’, live un-anaesthetized krill were confined for seven hours, during which three hours of optical imaging were obtained and no subsequent ill effects observed. The trap enabled two imaging methods to be employed: optical coherence tomography (OCT) and microscopy. OCT enabled internal structure and tissues to be imaged to a depth of approximately 2 mm and resolution of approximately 12 ...

      Read Full Article
    3. Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

      Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

      Microscale quantification of cilia-driven fluid flow is an emerging area in medical physiology, including pulmonary and central nervous system physiology. Cilia-driven fluid flow is most completely described by a three-dimensional, three-component (3D3C) vector field. Here, we generate 3D3C velocimetry measurements by synthesizing higher dimensional data from lower dimensional measurements obtained using two separate optical coherence tomography (OCT)-based approaches: digital particle image velocimetry (DPIV) and dynamic light scattering (DLS)-OCT. Building on previous work, we first demonstrate directional DLS-OCT for 1D2C velocimetry measurements in the sub-1 mm/s regime (sub-2.5 inch/minute regime) of cilia-driven fluid flow in Xenopus ...

      Read Full Article
    4. Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

      Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

      Purpose: To discriminate between subclinical fellow eyes of patients with keratoconus (scKCE) and normal eyes (NE) using swept-source Fourier-domain anterior segment optical coherence tomography (SS-OCT). Setting: University Medical Center Hamburg-Eppendorf, Germany. Design: Retrospective cross-sectional study. Methods: NE (both eyes with a KISA% Index <60; N = 213) and scKCE (KISA% Index <60, but an index of >100 in the fellow eye; N = 61) eyes were grouped according to the KISA% Index. Topography and tomography data were obtained by SS-OCT (Casia SS1000) and reviewed retrospectively. Receiver operating characteristics were performed for Casia SS1000 integrated automated parameters and newly computed indices. Additionally, discriminant ...

      Read Full Article
    5. Enamel Quality after Debonding: Evaluation by Optical Coherence Tomography

      Enamel Quality after Debonding: Evaluation by Optical Coherence Tomography

      The aims of this study were to evaluate quantitatively the enamel fractures, adhesive remnants and bracket fragments on enamel after debonding of metal and ceramic brackets, and to quantify the layer of adhesive remnants in depth after two different cleanup procedures. Metal and ceramic brackets were bonded on 120 human incisors and then debonded using two different techniques with Side Cutter (SC) and Anterior Bracket Removal plier (ABR). After this, a high-speed tungsten carbide finishing bur or a low-speed tungsten carbide finishing bur was used. The debonded samples were submitted to enamel assessment with optical coherence tomography (OCT). In sequence ...

      Read Full Article
    6. Real-Time Optical Coherence Tomography Segmentation?

      Real-Time Optical Coherence Tomography Segmentation?

      The recent publication, “Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region” by Tian et al. [1] raises the obvious question of what actually constitutes “real-time” processing? More broadly speaking, the paper reports on some segmentation results of OCT volumes acquired at the macula. The method used is based on graph traversal techniques that, when applied to image segmentation, allow the developer to very easily define boundaries from one side of an image to another in terms of their lowest cost traversal. For this traversal path to make sense, the input image data is first transformed ...

      Read Full Article
    7. Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line

      Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line

      Optical coherence tomography (OCT) with advantages of high resolution and high sensitivity is an emerging optical imaging technology that performs cross-sectional tomographic imaging of microstructure in biological system. In spite of the improvement of the longitudinal resolution by using low coherence light source, the dispersion effect aggravates with the increase of spectral bandwidth, which result in serious image blur and loss of image features. We demonstrate a double-path rapid scanning optical delay line (D-RSOD) structure in reference arm that produce the additional phase delay and group delay independent in OCT. The phase delay determined by grating defocus offset (GDO) of ...

      Read Full Article
    8. Application of fractional flow reserve and optical coherence tomography examinations in a patient presenting with recurrent angina: a case report

      Application of fractional flow reserve and optical coherence tomography examinations in a patient presenting with recurrent angina: a case report

      Introduction We present the different roles of fractional flow reserve and optical coherence tomography in guiding treatment in a patient with recurrent chest pain. Case presentation A 66-year-old Chinese woman presented to our department for the third time for her recurrent chest pain. Her physical examination was unremarkable; her previous two angiography examinations indicated that there was a stenosis of 50 to 70% in her proximal left anterior descending coronary artery. Optimal medical therapy was applied, but her symptoms did not disappear. Coronary angiography was conducted again after admission, accompanied by fractional flow reserve and optical coherence tomography. A lesion ...

      Read Full Article
    9. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the CLN3 gene. Conclusion: In these rare cases of juvenile neuronal ceroid lipofuscinosis, optical coherence tomography enabled unambiguous detection of prominent morphologic abnormalities of the retina at the patient's first ...

      Read Full Article
    10. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY

      Purpose: To describe the optical coherence tomography angiography features of diabetic retinopathy. Methods: Using a 70 kHz optical coherence tomography and the split-spectrum amplitude decorrelation angiography algorithm, 6 mm x 6 mm 3-dimensional angiograms of the macula of 4 patients with diabetic retinopathy were obtained and compared with fluorescein angiography for features cataloged by the Early Treatment of Diabetic Retinopathy Study. Results: Optical coherence tomography angiography detected enlargement and distortion of the foveal avascular zone, retinal capillary dropout, and pruning of arteriolar branches. Areas of capillary loss obscured by fluorescein leakage on fluorescein angiography were more clearly defined on optical ...

      Read Full Article
    11. Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study

      Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study

      Purpose : To evaluate macular thickness (MT) changes, using spectral domain optical coherence tomography (SD-OCT) in patients with optic disc pit (ODP) maculopathy after pars plana vitrectomy (PPV) with or without internal limiting membrane (ILM) peeling. Procedures : Our retrospective study included nine patients with ODP maculopathy, treated with either PPV ( n  = 5) or PPV with ILM peeling ( n  = 4). All participants, who had a mean long-term follow-up of 33.4 ± 7.0 months, underwent a complete ophthalmological examination and SD-OCT. Due to the preoperative macular elevation, the postoperative MT in the operated patients was compared with that of fellow eyes and ...

      Read Full Article
    12. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography

      Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography

      Oxygen supplementation [hyperoxia, increased fraction of inspired oxygen ( FiO 2 )] is an indispensable treatment in the intensive care unit for patients in respiratory failure. Like other treatments or drugs, hyperoxia has a risk-benefit profile that guides its clinical use. While hyperoxia is known to damage respiratory epithelium, it is unknown if damage can result in impaired capacity to generate cilia-driven fluid flow. Here, we demonstrate that quantifying cilia-driven fluid flow velocities in the sub - 100   μ m / s regime (sub-0.25 in./min regime) reveals hyperoxia-mediated damage to the capacity of ciliated respiratory mucosa to generate directional flow. Flow quantification was ...

      Read Full Article
    13. Two-grating Talbot bands spectral-domain interferometer

      Two-grating Talbot bands spectral-domain interferometer

      A configuration for Talbot bands is presented in which two tilted gratings replace the splitter normally used for recombining the signals from the two interferometer arms. The two optical beams from the interferometer are launched by two fiber leads tightly brought together in the front focal plane of a collimating lens. As the tips of the two fibers are slightly off-axis, the emergent beams after the collimating lens are not parallel. In combination with the two tilted gratings, the nonparallel launching of the two beams leads to a total elimination of mirror terms even when the two beams overlap on ...

      Read Full Article
    14. Natural History of Idiopathic Epiretinal Membrane in Eyes with Good Vision Assessed by Spectral-Domain Optical Coherence Tomography

      Natural History of Idiopathic Epiretinal Membrane in Eyes with Good Vision Assessed by Spectral-Domain Optical Coherence Tomography

      Purpose: To investigate the natural history of idiopathic epiretinal membrane (ERM) in eyes with good visual function using optical coherence tomography (OCT). Methods: Sixty-two eyes of 58 patients with idiopathic ERM, visual acuity of 20/40 or better, and no significant metamorphopsia were included. The best corrected visual acuity (BCVA), central macular thickness (CMT), membrane configuration, and ellipsoid zone signal data over 24 months were retrospectively analyzed. Based on OCT findings, ERM configurations were categorized as global attachment (GA), partial attachment (PA), pseudohole, and vitreomacular traction (VMT). Results: The mean BCVA and CMT did not change significantly between baseline and ...

      Read Full Article
    15. Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease - American Journal of Ophthalmology

      Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease - American Journal of Ophthalmology

      Purpose To determine the proportion of shallow irregular pigment epithelial detachments in eyes with pachychoroid features that harbor neovascular tissue and to study the morphology of this tissue with optical coherence tomography (OCT) angiography. Design Prospective consecutive cohort study. Methods Patients with pachychoroid spectrum diagnoses and shallow irregular pigment epithelial detachment in at least one eye (study eye) were included. Charts and multimodal imaging were reviewed to determine a dye-angiography detection rate for type 1 neovascularization in study eyes. All patients then underwent OCT angiography prospectively followed by masked segmentation and grading. Results 22 eyes of 16 patients were included ...

      Read Full Article
      Mentions: K. Bailey Freund
    16. En face optical coherence tomography angiography for corneal neovascularisation

      En face optical coherence tomography angiography for corneal neovascularisation

      Background/aim Recently, there has been an increasing clinical need for objective evaluation of corneal neovascularisation, a condition which cause significant ocular morbidity. We describe the use of a rapid, non-invasive ‘en face’ optical coherence tomography angiography (OCTA) system for the assessment of corneal neovascularisation. Methods Consecutive patients with abnormal corneal neovascularisation were scanned using a commercially available AngioVue OCTA system (Optovue, Fremont, California, USA) with the split-spectrum amplitude decorrelation angiography algorithm, using an anterior segment lens adapter. Each subject had four scans in each eye by a trained operator and two independent masked assessors analysed all images. Main outcome ...

      Read Full Article
    17. Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

      Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

      Optical coherence tomography angiography has recently been used to visualize choroidal neovascularization (CNV) in participants with age-related macular degeneration. Identification and quantification of CNV area is important clinically for disease assessment. An automated algorithm for CNV area detection is presented in this article. It relies on denoising and a saliency detection model to overcome issues such as projection artifacts and the heterogeneity of CNV. Qualitative and quantitative evaluations were performed on scans of 7 participants. Results from the algorithm agreed well with manual delineation of CNV area.

      Read Full Article
    18. First Annual OCT Angiography Summit Signals a New Era in Imaging Technology

      First Annual OCT Angiography Summit Signals a New Era in Imaging Technology

      OCT Angiography: The Next Game Changer in OCT Scientists, clinicians and engineers from throughout the world gathered in Portland, Oregon, USA for the first annual OCT Angiography Summit meeting. Participants spent the day sharing their knowledge and discussing applications of a breakthrough imaging technology that may someday transform the way we diagnose and care for patients with the most common causes of blindness, namely macular degeneration, glaucoma and diabetes. Currently, these innovations are being applied in ophthalmology and are proving to be a superior alternative to dye-based methods for visualizing and measuring blood flow in the back of the eye ...

      Read Full Article
    19. Swept-Source OCT: Patent License Agreement between Massachusetts General Hospital and Heidelberg Engineering

      Swept-Source OCT: Patent License Agreement between Massachusetts General Hospital and Heidelberg Engineering

      Heidelberg Engineering has entered into a patent license agreement with Massachusetts General Hospital (MGH) in Boston. The agreement grants global and exclusive rights to 77 basic patents and patent applications which relate to swept-source OCT technology and its application in ophthalmology. Spectral domain OCT has become indispensable to eye care professionals worldwide to diagnose and follow-up patients with diseases of the posterior segment of the eye, such as age-related macular degeneration, diabetic retinopathy, or glaucoma. Swept-source OCT technology has specific characteristics which are ideal to acquire comprehensive information about a wide variety of properties of the anterior part of the ...

      Read Full Article
    20. Automatic cysts detection in optical coherence tomography images

      Automatic cysts detection in optical coherence tomography images

      The main goal of this work is a presentation of a new algorithm dedicated to cysts detection in Optical Coherence Tomography (OCT) images. Considered in this paper OCT scans concern the eyeball examination in ophthalmology. The proposed approach utilizes different image processing techniques including non-linear complex diffusion and mathematical morphology operations and algorithms, in particular H-Minima Transform, image reconstruction by erosion, geodesic operations etc. The algorithm — to confirm its effectiveness — has been verified based on OCT series

      Read Full Article
    21. SUBRETINAL NEOVASCULARIZATION IN MACULAR TELANGIECTASIA TYPE 2: OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY AND TREATMENT RESPONSE

      SUBRETINAL NEOVASCULARIZATION IN MACULAR TELANGIECTASIA TYPE 2: OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY AND TREATMENT RESPONSE

      Purpose: To report the optical coherence tomographic angiography findings and response to treatment in a case of macular telangiectasia Type 2 with subretinal neovascularization. Methods: Case report. Results: A 64-year-old man with macular telangiectasia Type 2 developed subretinal neovascularization, which was imaged on optical coherence tomographic angiography. He was treated with intravitreal aflibercept, and there was a remarkable reduction of flow in the subretinal neovascular network on optical coherence tomographic angiography. Conclusion: Optical coherence tomographic angiography provides detailed information on the retinal microvasculature and subretinal neovascularization in macular telangiectasia Type 2. It can be used to assess response to treatment.

      Read Full Article
    22. Lateral resolution enhancement using programmable phase modulator in optical coherence tomography

      Lateral resolution enhancement using programmable phase modulator in optical coherence tomography

      Adaptive optics plays an important role in the correction of high-order aberrations to enhance lateral resolution. An OCT system coupled with a programmable phase modulator is designed to verify lateral resolution improvement. The Hamamatsu high-resolution, non-pixelized, optically addressed light modulator (PAL-SLM) PPM X7550 series is used to correct aberrations, utilizing a simple method based on phase information from OCT images. The advantages of this method are its high simplicity and low cost. A raster scanning technique is adopted to scan samples covered with scattering suspension. Metal lines covered with scattering suspension are imaged, and a respective correction is applied to ...

      Read Full Article
    23. Familial Exudative Vitreoretinopathy: Spectral-Domain Optical Coherence Tomography of the Vitreoretinal Interface, Retina, and Choroid

      Familial Exudative Vitreoretinopathy:  Spectral-Domain Optical Coherence Tomography of the Vitreoretinal Interface, Retina, and Choroid

      Purpose The in vivo microstructural features of familial exudative vitreoretinopathy (FEVR) have not been well described. We present new anatomic features of FEVR with functional and genetic correlations. Design Consecutive, retrospective, observational case series. Participants Patients with FEVR treated from 2009 to 2014. Methods We identified 346 patients with FEVR. Those imaged with spectral-domain optical coherence tomography (SD OCT) with or without enhanced depth imaging (EDI) were included, and images were correlated with best-corrected visual acuity (BCVA), widefield angiography, fundus autofluorescence (AF), and wnt signaling pathway mutations. Main Outcome Measures Exploratory SD OCT findings and BCVA. Results A total of ...

      Read Full Article
    25-48 of 17540 « 1 2 3 4 5 ... 729 730 731 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Optical Coherence Tomography News

    See all Optical Coherence Tomography News articles
  4. Organizations in the News

    1. (539 articles) Harvard University
    2. (476 articles) Massachusetts Institute of Technology
    3. (459 articles) Massachusetts General Hospital
    4. (405 articles) National Institutes of Health
    5. (356 articles) Duke University
    6. (308 articles) Johns Hopkins University
    7. (308 articles) Medical University of Vienna
    8. (305 articles) University of Miami
    9. (290 articles) University of Southern California
    10. (261 articles) FDA
  5. People in the News

    1. (325 articles) James G. Fujimoto
    2. (221 articles) Joseph A. Izatt
    3. (207 articles) David Huang
    4. (183 articles) Ruikang K. Wang
    5. (181 articles) Stephen A. Boppart
    6. (168 articles) Guillermo J. Tearney
    7. (167 articles) Zhongping Chen
    8. (167 articles) Adrian G. Podoleanu
    9. (156 articles) Patrick W. Serruys
    10. (153 articles) Brett E. Bouma
  6. OCT Companies in the News

    1. (1369 articles) Carl Zeiss Meditec
    2. (738 articles) St. Jude Medical
    3. (527 articles) Heidelberg Engineering
    4. (390 articles) Optovue
    5. (320 articles) Volcano Corporation
    6. (290 articles) Topcon Medical Systems
    7. (216 articles) Michelson Diagnostics
    8. (190 articles) Bioptigen
    9. (163 articles) Thorlabs
    10. (129 articles) Boston Scientific
  7. OCT Products in the News

    1. (563 articles) Zeiss Stratus OCT
    2. (534 articles) Zeiss Cirrus HD-OCT
    3. (514 articles) Heidelberg Spectralis
    4. (289 articles) Optovue RTVue-100
    5. (209 articles) Zeiss Visante OCT
    6. (143 articles) Lightlab C7 XR OCT Imaging System
    7. (110 articles) Lightlab M3 Imaging Console
    8. (106 articles) Michelson Diagnostics Vivosight
    9. (100 articles) Topcon 3D OCT-1000
    10. (46 articles) Imalux Niris