1. All Articles

    25-48 of 15512 « 1 2 3 4 5 ... 645 646 647 »
    1. Automated 3D Segmentation of Intraretinal Surfaces in SD-OCT Volumes in Normal and Diabetic Mice

      Automated 3D Segmentation of Intraretinal Surfaces in SD-OCT Volumes in Normal and Diabetic Mice

      Purpose: To describe an adaptation of an existing graph-theoretic method (initially developed for human optical coherence tomography [ OCT ] images) for the three-dimensional ( 3D ) automated segmentation of 10 intraretinal surfaces in mice scans, and assess the accuracy of the method and the reproducibility of thickness measurements. Methods: Ten intraretinal surfaces were segmented in repeat spectral domain ( SD )- OCT volumetric images acquired from normal ( n = 8) and diabetic ( n = 10) mice . The accuracy of the method was assessed by computing the border position errors of the automated segmentation with respect to manual tracings obtained from two experts. The reproducibility was statistically assessed ...

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    2. Real-time, noninvasive optical coherence tomography of cross-sectional living cell-sheets in vitro and in vivo

      Real-time, noninvasive optical coherence tomography of cross-sectional living cell-sheets in vitro and in vivo

      Cell sheet technology has a history of application in regenerating various tissues, having successfully completed several clinical trials using autologous cell sheets. Tomographic analysis of living cell sheets is an important tool in the field of cell sheet-based regenerative medicine and tissue engineering to analyze the inner structure of layered living cells. Optical coherence tomography (OCT) is commonly used in ophthalmology to noninvasively analyze cross-sections of target tissues at high resolution. This study used OCT to conduct real-time, noninvasive analysis of living cell sheet cross sections. OCT showed the internal structure of cell sheets in tomographic images synthesized with backscatter ...

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    3. Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Background The aim was to assess the macular parameters of glaucoma in highly myopic subjects. Methods In a retrospective study, we enrolled 72 highly myopic eyes (spherical equivalent up to -6.00 D), of which 31 had early to moderate glaucoma and 41 formed a control group. The diagnosis of early to moderate glaucoma was based on glaucomatous visual-field defects with a mean deviation better than -12 dB. All patients underwent imaging with Stratus optical coherence tomography. We subsequently performed analysis for macular volume and thickness parameters between two groups. Results Using Stratus optical coherence tomography, we found significantly lower ...

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    4. Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Purpose To evaluate first and second order responses on multifocal electroretinogram (mfERG) and with retinal nerve fibre layer thickness (RNFL) on Cirrus spectral domain optical coherence tomography (SD-OCT) in glaucoma. Methods Patients (old and new) diagnosed with primary open angle glaucoma, primary angle closure glaucoma or normal tension glaucoma attending glaucoma services from November 2012 to January 2013 were screened. Ninety-seven eyes fulfilling inclusion criteria were evaluated by Humphrey visual field, Cirrus SD-OCT imaging and mfERG (Veris Science 5.1.10X; EDI, Redwood City, California, USA) for this observational cross-sectional study. The global and averaged quadrant-wise peak-to-trough amplitudes and peak ...

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    5. Non-destructive stress profile determination in chemically tempered glass

      Non-destructive stress profile determination in chemically tempered glass

      Apparatus, systems and methods for improving strength of thin cover glass for electronic devices are disclosed. Optical coherence tomography analysis may reveal fine details of a residual stress profile within chemically strengthened cover glass. One or more parameters of chemical strengthening treatments may be adjusted, based upon the analysis of the residual stress profile.

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    6. Cystic Fibrosis, COPD Patients Could Benefit From Nanoparticle-based Mucus

      Cystic Fibrosis, COPD Patients Could Benefit From Nanoparticle-based Mucus

      An Optical Society release notes that while people might typically regard mucus as an “icky bodily secretion best left wrapped in a tissue,” for a group of researchers from the University of North Carolina at Chapel Hill , “snot is an endlessly fascinating subject.” The team has developed a way to use gold nanoparticles and lasers to measure the viscosity (“stickiness”) of the slimy secretion that lines our airways. The new method could help doctors better monitor and treat lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease .

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    7. Feature of the Week 10/26/14: 3D Polymer Weld Seam Characterization Based on OCT Laser Transmission Welding Applications

      Feature of the Week 10/26/14: 3D Polymer Weld Seam Characterization Based on OCT Laser Transmission Welding Applications

      Plastics have low weight but a high weight to strength ratio and a good corrosion resistance allied to a high degree of freedom on its form design. These characteristics lead plastics to be used in several technical systems with high production and application requirements. Herewith the complete production chain of these components as well as their integration in technical systems are also subjected to high standards. The joining of plastics and polymers is an important step in this process chain, as often at this stage pre-processed parts with a high added value are machined. Especially in high performance production chains ...

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    8. Serial Spectral Domain Ocular Coherence Tomography Measurement of Outer Nuclear Layer Thickness in Rhegmatogenous Retinal Detachment Repair

      Serial Spectral Domain Ocular Coherence Tomography Measurement of Outer Nuclear Layer Thickness in Rhegmatogenous Retinal Detachment Repair

      Introduction : The outer nuclear layer (ONL) contains mostly photoreceptor bodies and reduced post-operative ONL thickness (ONLT) is associated with poor visual outcome in rhegmatogenous retinal detachment (RRD). Methods : Spectral domain ocular coherence tomography was recorded before and 6 weeks following RRD repair in 27 consecutive patients. Results : The repair consisted of combined 20-guage pars plana vitrectomy (PPV) and encirclement in 66.7% of cases, 22.2% underwent PPV alone and 11.1% scleral buckle alone. The mean (± standard deviation) ONLT was reduced in detached retinae (94.1 ± 31.1 microns) compared to the unaffected eye (119.5 ± 26.8 microns ...

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    9. Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, while retinal neurodegeneration can be quantified in vivo using optical coherence tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC–IPL) thinning with global and regional cerebral atrophy on magnetic resonance imaging (MRI). Malay participants aged 60–80 years from the Epidemiology of Dementia in Singapore Study underwent comprehensive examinations, including 3-Tesla cranial MRI. RNFL and GC-IPL thicknesses were obtained from spectral domain-OCT; and cerebral grey and white matter volumes were obtained from MRI scans using a validated segmentation tool. Linear ...

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    10. Spectral domain optical coherence tomography imaging in optic disk pit associated with outer retinal dehiscence

      Spectral domain optical coherence tomography  imaging in optic disk pit associated with outer  retinal dehiscence

      A 37-year-old Bangladeshi male presented with an inferotemporal optic disk pit and serous macular detachment in the left eye. Imaging with spectral domain optical coherence tomography (OCT) revealed a multilayer macular schisis pattern with a small subfoveal outer retinal dehiscence. This case illustrates a rare phenotype of optic disk maculopathy with macular schisis and a small outer retinal layer dehiscence. Spectral domain OCT was a useful adjunct in delineating the retinal layers in optic disk pit maculopathy, and revealed a small area of outer retinal layer dehiscence that could only have been detected on high-resolution OCT.

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    11. Outcomes of everolimus-eluting stent incomplete stent apposition: a serial optical coherence tomography analysis

      Outcomes of everolimus-eluting stent incomplete stent apposition: a serial optical coherence tomography analysis

      Aim The aim of the present study was to evaluate the natural course of acute incomplete stent apposition (ISA) after second-generation everolimus-eluting stent (EES) when compared with first-generation sirolimus-eluting stent (SES) by using optical coherence tomography (OCT). Methods and results From the OCT substudy of the RESET trial, we identified 77 patients (EES = 38 and SES = 39) who successfully underwent serial OCT examination at post-stenting and 8–12-month follow-up. The presence of ISA was assessed in the OCT images, and ISA distance was measured from the centre of the strut blooming to the adjacent lumen border. Incomplete stent apposition was ...

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    12. Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Purpose: To investigate the influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain optical coherence tomography (OCT) on the diagnostic ability of early glaucoma. Methods: Sixty-four early (including 24 pre-perimetric) glaucomatous and 40 normal eyes underwent macular and peripapillary retinal nerve fiber layer (pRNFL) scans (3D-OCT-2000, Topcon). The area under the receiver operating characteristics (AUC) for glaucoma diagnosis was determined from the average thickness of the total 100 grids (6x6 mm), the central 44 grids (3.6x4.8 mm) and the peripheral 56 grids (outside of the 44 grids) and for each macular sublayer ...

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    13. Correlations Amongst Near-Infrared and Short-Wavelength Autofluorescence and Spectral Domain Optical Coherence Tomography in Recessive Stargardt Disease

      Correlations Amongst Near-Infrared and Short-Wavelength Autofluorescence and Spectral Domain Optical Coherence Tomography in Recessive Stargardt Disease

      Purpose: Short-wavelength (SW) fundus autofluorescence (AF) is considered to originate from lipofuscin in retinal pigment epithelium (RPE) and near-infrared (NIR) AF from melanin. In patients with recessive Stargardt disease (STGD1), we correlated SW-AF and NIR-AF with structural information obtained by spectral domain optical coherence tomography (SD-OCT). Methods: Twenty-four STGD1 patients (45 eyes; age 8 to 61 years) carrying confirmed disease-associated ABCA4 mutations were studied prospectively. SW-AF, NIR-AF and SD-OCT images were acquired. Results: Five phenotypes were identified according to features of the central lesion and extent of fundus change. Central zones of reduced NIR-AF were typically larger than areas of ...

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    14. Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Intravascular optical coherence tomography (IVOCT) is a well-established method for the high-resolution investigation of atherosclerosis in vivo. Intravascular near-infrared fluorescence (NIRF) imaging is a novel technique for the assessment of molecular processes associated with coronary artery disease. Integration of NIRF and IVOCT technology in a single catheter provides the capability to simultaneously obtain co-localized anatomical and molecular information from the artery wall. Since NIRF signal intensity attenuates as a function of imaging catheter distance to the vessel wall, the generation of quantitative NIRF data requires an accurate measurement of the vessel wall in IVOCT images. Given that dual modality, intravascular ...

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    15. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

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    16. Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Purpose To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber ...

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    17. Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Speckle reduction in optical coherence tomography (OCT) images plays an important role in facilitating further image analysis. Existing despeckling methods generally tend to provide insufficient speckle suppression or limited detail preservation especially at high speckle corruption. To address this problem, this paper proposes a novel iterative nonlocal means (NLM) method to restore OCT images. Different from the classical NLM method, the proposed method computes the weight using an improved weight function in an iterative way and it determines the decay parameter based on the classification of image pixels. The experiments on the clinical OCT images indicate that the proposed method ...

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    18. Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Purpose To compare foveal shapes in Koreans according to age and gender using spectral domain optical coherence tomography (SD-OCT). Methods This study included 230 eyes of 115 healthy adults. The subjects were divided into three groups: group 1 (20-39 years of age), group 2 (40-59 years of age) and group 3 (60-79 years of age). Using spectralis OCT, we measured central foveal thickness (CFT), regional maximal retinal thickness (MRT), pit diameter and pit depth and compared the differences between the groups. Results The MRT of the superior, inferior and nasal sides in group 1 was higher than in groups 2 ...

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    19. Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. The meeting will be organised around 2-3 invited talks, technical sessions with poster sessions interspersed. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. There is no fee for this meeting, however registration is required. Tea, coffee and lunch will be provided for attendants. Please email Mark.Dickinson@manchester.ac.uk or P.H.Tomlins@qmul.ac.uk or N.Krstajic@ed.ac.uk in ...

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    20. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

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    21. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

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    22. Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young, and elderly subjects. Methods: Doppler FD-OCT blood flow was measured using the RTVue system (Optovue Inc., USA). One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ± 5.1 years) subjects was randomly selected and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e. each separate measurement comprising an upper, and ...

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    23. Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Purpose:To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure (PMAC) eyes, mature cataract eyes and their fellow eyes, and identify those parameters that could be used to differentiate PMAC eyes from those with mature cataract and no PMAC. Methods:In this cross-sectional study a total of 33 PMAC subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth(ACD), anterior chamber area(ACA), iris thickness, iris curvature, lens vault(LV), and angle parameters including angle opening distance(AOD750) and trabecular ...

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