1. All Articles

    25-48 of 16008 « 1 2 3 4 5 ... 665 666 667 »
    1. Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Purpose The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects. Methods Sixteen healthy subjects (eight male/eight female) aged between 20 and 36 years were included in this randomized, double-masked placebo-controlled study. One eye received a single dose of hyaluronic acid (Olixia pure ® ; Croma Pharma, Korneuburg, Austria) eye drops, and the fellow eye received physiologic saline solution as placebo control. The study eye was chosen randomly. TFT as measured with a custom-built Fourier-domain optical coherence tomography (FD-OCT) system was the main outcome variable and ...

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    2. OPTICAL COHERENCE TOMOGRAPHY-BASED POSITIONING REGIMEN FOR MACULAR HOLE SURGERY

      OPTICAL COHERENCE TOMOGRAPHY-BASED POSITIONING REGIMEN FOR MACULAR HOLE SURGERY

      Purpose: To evaluate an optical coherence tomography (OCT)-based positioning regimen for patients undergoing macular hole surgery. Method: We reviewed the medical records of all patients in our practice who underwent macular hole repair, instituting a modified OCT-based positioning regimen from November 1, 2011 through July 31, 2013. The regimen consisted of prone positioning at the conclusion of surgery with daily OCT imaging until the hole was confirmed closed at which point positioning was halted. Clinical data that were collected and recorded included visual acuities, stage of hole, size of hole, chronicity, preoperative and postoperative OCT imaging, and length of ...

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    3. Eccentric morphology of jailed side-branch ostium after stent crossover in coronary bifurcation lesions: A three-dimensional optical coherence tomographic analysis

      Eccentric morphology of jailed side-branch ostium after stent crossover in coronary bifurcation lesions: A three-dimensional optical coherence tomographic analysis

      Background Angiographic stenosis of a jailed side-branch ostium is usually observed after a single-stent crossover at coronary bifurcation lesions. However, the stenosis severity is typically overestimated due to the limited information obtained from two-dimensional morphology by angiography. We evaluated the actual stenosis of jailed side-branch ostium using three-dimensional (3D) optical coherence tomography (OCT). Methods Using 3D reconstructions of OCT data, we analyzed minimal lumen area (MLA) and eccentricity of the jailed side-branch ostium in 41 patients who were treated with single stent crossover at coronary bifurcation lesions and subsequently underwent serial OCT follow-up. Results The MLA of jailed side-branch ostium ...

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    4. Comparison between the measurements of different parameters obtained from optic nerve head analysis by using Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT)

      Comparison between the measurements of different parameters obtained from optic nerve head analysis by using Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT)

      Purpose: A cross-sectional prospective nonrandomized study was undertaken to find out whether Heidelberg retinal tomography (HRT3) and Optical coherence tomography (Stratus OCT) could be used interchangeably for the measurement of different parameters of optic nerve head in clinical practice. Materials and Methods: Measurements of disc area, cup area, rim area and cup-disc area ratio were obtained with the HRT3 and Stratus OCT printouts in 18 patients aged 20 to 70 years. True agreements between methods in measuring disc area, cup area, rim area and cup-disc area ratio were assessed using Bland-Altman statistical analysis. Eighteen patients with a mean age of ...

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    5. Optical Coherence Tomography (Textbook)

      Optical Coherence Tomography (Textbook)

      This book presents the state-of-the-art information regarding optical coherence tomography. Optical coherence tomography (OCT) is an imaging technique providing high-resolution cross-sectional images in several fields of engineering and medicine. OCT images are created by measuring the intensity of reflected or back scattered light which is scanned across the tissue and material. The aim of this book is to present elaborative information on OCT in a wide spectrum of fields including oncology, engineering, ophthalmology and atherosclerosis

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    6. Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

      Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

      Background : The present cross-sectional study has the purpose to investigate the impact of aromatase inhibitors (AIs) on retinal nerve fiber layer (RNFL) thickness, optic nerve and macular function in patients using AIs for breast cancer treatment. Methods : Participants in our study were 41 hormone-receptor-positive earlystage breast cancer patients who were treated with AIs in the adjuvant setting. Moreover, 40 age- and gender-matched control subjects, having neither ocular nor systemic disorders, were included in this study. All participants underwent a complete ophthalmological examination, including best corrected visual acuity (BCVA) assessment, RNFL thickness and central foveal thickness (CFT) measurement, visual evoked potentials ...

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    7. The effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomography Read More: http://informahealthcare.com/doi/abs/10.3109/15569527.2014.990154

      The effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomography   Read More: http://informahealthcare.com/doi/abs/10.3109/15569527.2014.990154

      Objective : The purpose of this study was to examine the vasoreactivity in retina and choroid of the healthy eyes in response to experimentally altered partial arterial pressure of carbon dioxide (PaCO 2 ) using a non-invasive technique, spectral domain optical coherence tomography (SD-OCT). Materials and methods : The study included non-smoking participants between 18 and 35 years of age, having visual acuity of 20/20 and with no systemic and ocular diseases. At baseline, the participants breathed room air (normocapnia). Hypocapnia was created with the help of hyperventilation; for this, the participants were instructed to draw deep and quick breaths, resulting one ...

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    8. Bausch + Lomb Introduces New Software and Advanced OCT Imaging System for VICTUS® Femtosecond Laser Platform

      Bausch + Lomb Introduces New Software and Advanced OCT Imaging System for VICTUS® Femtosecond Laser Platform

      Valeant Pharmaceuticals International, Inc. (NYSE: VRX and TSX: VRX) today announced that its wholly owned subsidiary, Bausch + Lomb, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for an advanced Swept Source OCT (Optical Coherence Tomography) imaging system and updated software for its VICTUS ® Femtosecond Laser Platform that will provide surgeons with a new, redesigned interface. The intuitive interface is designed to allow faster, simpler customized treatment planning to help surgeons improve efficiency and patient-flow during surgical procedures. "With the availability of the advanced OCT imaging and software enhancements, surgeons can monitor treatments in real-time ...

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    9. Optical Coherence Tomography: Detecting Disease Early Through Retinal Imaging

      Optical Coherence Tomography: Detecting Disease Early Through Retinal Imaging

      Early diagnosis of individuals with chronic disease is a global health goal because the sooner a physician can detect a disease in a patient, the better the prognosis. In the U.S. alone, more than 6 million people have diabetes without knowing it, according to a 2009 study. That study estimated the cost of undiagnosed type-2 diabetes in medical services and lost productivity to be $18 billion a year. Eye researchers have observed that many chronic diseases, such as diabetes, hypertension, and cardiovascular and cerebrovascular conditions, leave telltale clues of their presence in the retina. By detecting these clues using ...

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    10. Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography

      Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography

      In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.

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    11. Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Ophthalmologists typically acquire different image modalities to diagnose eye pathologies. They comprise, e.g., Fundus photography, optical coherence tomography, computed tomography, and magnetic resonance imaging (MRI). Yet, these images are often complementary and do express the same pathologies in a different way. Some pathologies are only visible in a particular modality. Thus, it is beneficial for the ophthalmologist to have these modalities fused into a single patient-specific model. The goal of this paper is a fusion of Fundus photography with segmented MRI volumes. This adds information to MRI that was not visible before like vessels and the macula. This paper ...

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    12. Hypersensitivity Reaction in the US Food and Drug Administration-Approved Second-Generation Drug-Eluting Stents: Histopathological Assessment With Ex Vivo Optical Coherence Tomography

      Hypersensitivity Reaction in the US Food and Drug Administration-Approved Second-Generation Drug-Eluting Stents: Histopathological Assessment With Ex Vivo Optical Coherence Tomography

      A 55-year-old white man received 4 coronary stents, 3 Resolute zotarolimus-eluting stents (R-ZES; Medtronic, Santa Rosa, CA) and 1 XIENCE Xpedition (CoCr-EES; Abbott Vascular, Santa Clara, CA), for unstable angina pectoris 238 days antemortem. The patient was found dead and had recently been seen without any complaints. The patient had a history of hypertension, hyperlipidemia, and smoking. At the time of stent placement, coronary angiography revealed diffuse disease in the left anterior descending artery (LAD) with severe stenosis of the proximal LAD and moderate to severe stenosis of the mid LAD. Percutaneous coronary intervention was carried out, and 4 overlapping ...

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    13. Evaluation of Coronary Adventitial Vasa Vasorum Using 3D Optical Coherence Tomography - Animal and Human Studies

      Evaluation of Coronary Adventitial Vasa Vasorum Using 3D Optical Coherence Tomography - Animal and Human Studies

      Objectives This study sought to evaluate adventitial vasa vasorum (VV) in vivo with novel imaging technique of optical coherence tomography (OCT). Methods To verify OCT methods for quantification of VV, we first studied 2 swine carotid arteries in a model of focal angiogenesis by autologous blood injection, and compared microchannel volume (MCV) by OCT and VV by m-CT, and counts of those. In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border. After manually tracing microchannel areas and the boundaries of lumen-intima and media-adventitial in all slices, we reconstructed 3D ...

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    14. Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications

      Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications

      Gas assisted laser machining of materials is a common practice in the manufacturing industry. Advantages in using gas assistance include reducing the likelihood of flare-ups in flammable materials and clearing away ablated material in the cutting path. Current surgical procedures and research do not take advantage of this and in the case for resecting osseous tissue, gas assisted ablation can help minimize charring and clear away debris from the surgical site. In the context of neurosurgery, the objective is to cut through osseous tissue without damaging the underlying neural structures. Different inert gas flow rates used in laser machining could ...

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    15. Simultaneous birefringence imaging and depth phase resolved measurement using a Fourier domain OCT system

      Simultaneous birefringence imaging and depth phase resolved measurement using a Fourier domain OCT system

      A low cost optical coherence tomography (OCT) system to measure simultaneously the birefringence and the internal deformation of a porcine cornea is proposed. The optical system uses polarized light to recover simultaneously the s and p polarization states while a couple of cameras record a fringe pattern that serves to reconstruct the internal structure of the cornea. The p and s interference signals are registered separately in each 2D CMOS array which generates in a single shot an entire B-scan, a feature that allows the tracking of non-repeatable deformations. A birefringence map is generated within the tissue when the p ...

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    16. Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Purpose: We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: The ...

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    17. New neuroretinal rim analysis with spectral domain optical coherence tomography, Spectralis (Heidelberg Engineering, Germany). Preliminary study

      New neuroretinal rim analysis with spectral domain optical coherence tomography, Spectralis (Heidelberg Engineering, Germany). Preliminary study

      Introduction Clinical determination of the outer limits of the optic disk (OD) doesn’t always correspond to the true anatomic limits of the optic nerve head (ONH) defined by the Bruch's membrane opening (BMO). A new index analyzing the OD with optical coherence tomography (OCT), “minimal rim width” (BMO-MRW), evaluates the smallest thickness of the neuroretinal rim between the BMO and the internal limiting membrane. The purpose of this study was to evaluate new software for automatic measurement of the BMO-MRW. Materials and methods This study investigated 95 eyes: 40 control eyes and 55 eyes followed and treated for ...

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    18. Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Background: Otitis media (OM), an infection in the middle ear, is extremely common in the pediatric population. Current gold-standard methods for diagnosis include otoscopy for visualizing the surface features of the tympanic membrane (TM) and making qualitative assessments to determine middle ear content. OM typically presents as an acute infection, but can progress to chronic OM, and after numerous infections and antibiotic treatments over the course of many months, this disease is often treated by surgically inserting small tubes in the TM to relieve pressure, enable drainage, and provide aeration to the middle ear. Diagnosis and monitoring of OM is ...

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    19. Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report

      Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report

      45-year-old man was diagnosed with a 3 mm × 3 mm iris cyst located at 9 o’clock behind iris and protruding into temporal angle by slit lamp examination, gonioscopy, and ultrasound biomicroscopy (UBM). Phase-sensitive optical coherence tomography (PhS-OCT) was applied on this case for the quantitative measurements of trabecular meshwork (TM) motion. The frequency of TM motion was with the same rhythm of the patient’s peripheral pulse. Its amplitude on the closed angle region showed significant smaller than the open angle region. PhS-OCT can be a useful tool for the diagnosis and follow-up in ocular diseases surrounding iridocorneal angle.

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    20. Correlation between Fourier-Domain Optical Coherence Tomography Parameters and HbA1c Level and Diabetes Duration in Early Stage Diabetic Retinopathy

      Correlation between Fourier-Domain Optical Coherence Tomography Parameters and HbA1c Level and Diabetes Duration in Early Stage Diabetic Retinopathy

      We examined a significant correlation between Fourier-domain optical coherence tomography (FD-OCT) parameters and the glycosylated hemoglobin A1c (HbA1c) level and duration of diabetes mellitus (DM) in patients at the early stage of diabetic retinopathy (DR). Thirty eyes of 30 patients with early stage DR that were examined at the Chiba University Hospital were studied. The macular map 5 (MM5), the retinal nerve fiber layer thickness, and the ganglion cell complex thickness were obtained by FD-OCT. The coefficients of correlation between these parameters and the HbA1c level and the DM duration were determined by Spearman rank correlation. The thickness of the ...

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    21. In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF ...

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    22. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), especial swept-source OCT, is preferred. Good publication record and communication skills. Strong programming skills (Matlab, Labview, C++ and GPU programming) are pluses. Research areas: The ...

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    23. New developments in optical coherence tomography

      New developments in optical coherence tomography

      Purpose of review: Optical coherence tomography (OCT) has become the cornerstone technology for clinical ocular imaging in the past few years. The technology is still rapidly evolving with newly developed applications. This manuscript reviews recent innovative OCT applications for glaucoma diagnosis and management. Recent findings: The improvements made in the technology have resulted in increased scanning speed, axial and transverse resolution, and more effective use of the OCT technology as a component of multimodal imaging tools. At the same time, the parallel evolution in novel algorithms makes it possible to efficiently analyze the increased volume of acquired data. Summary: The ...

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    24. Optical coherence tomography based microangiography for quantitative monitoring of structural and vascular changes in a rat model of acute uveitis in vivo: a preliminary study

      Optical coherence tomography based microangiography for quantitative monitoring of structural and vascular changes in a rat model of acute uveitis in vivo: a preliminary study

      Uveitis models in rodents are important in the investigation of pathogenesis in human uveitis and the development of appropriate therapeutic strategies for treatment. Quantitative monitoring of ocular inflammation in small animal models provides an objective metric to assess uveitis progression and/or therapeutic effects. We present a new application of optical coherence tomography (OCT) and OCT-based microangiography (OMAG) to a rat model of acute anterior uveitis induced by intravitreal injection of a killed mycobacterial extract. OCT/OMAG is used to provide noninvasive three-dimensional imaging of the anterior segment of the eyes prior to injection (baseline) and two days post-injection (peak ...

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