1. All Articles

    25-48 of 16796 « 1 2 3 4 5 ... 698 699 700 »
    1. Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis

      Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis

      Optical imaging modalities such as fluorescence (FL) microscopy, multiphoton microscopy, and optical coherence tomography (OCT) have been well established for high optical contrast and high spatial resolution imaging of biological tissues. However, as they are dependent on ballistic photons, these methods fail to image beyond ~1 mm or so inside biological tissue. In contrast, diffuse optical imaging (DOI), which uses multiple scattered photons for imaging, can image much deeper (up to a several centimeters) into the tissue. Unfortunately, due to strong light scattering in tissues, it fails to maintain the high resolution at the deeper imaging depth. Photoacoustic imaging (PAI ...

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    2. Evaluation of choroidal thickness via enhanced depth-imaging optical coherence tomography in patients with systemic hypertension

      Evaluation of choroidal thickness via enhanced depth-imaging optical coherence tomography in patients with systemic hypertension

      Purpose: The purpose was to evaluate choroidal thickness via spectral domain optical coherence tomography (SD-OCT) and to compare the data with those of 24-h blood pressure monitoring, elastic features of the aorta, and left ventricle systolic functions, in patients with systemic hypertension. Materials and Methods: This was a case-control, cross-sectional prospective study. A total of 116 patients with systemic hypertension, and 116 healthy controls over 45 years of age, were included. Subfoveal choroidal thickness (SFCT) was measured using a Heidelberg SD-OCT platform operating in the enhanced depth imaging mode. Patients were also subjected to 24-h ambulatory blood pressure monitoring (ABPM ...

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    3. UTILIZATION OF FUNDUS AUTOFLUORESCENCE, SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY, AND ENHANCED DEPTH IMAGING IN THE CHARACTERIZATION OF BIETTI CRYSTALLINE DYSTROPHY IN DIFFERENT STAGES

      UTILIZATION OF FUNDUS AUTOFLUORESCENCE, SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY, AND ENHANCED DEPTH IMAGING IN THE CHARACTERIZATION OF BIETTI CRYSTALLINE DYSTROPHY IN DIFFERENT STAGES

      Purpose: To characterize Bietti crystalline dystrophy (BCD) in different stages using multiple imaging modalities. Methods: Sixteen participants clinically diagnosed as BCD were included in the retrospective study and were categorized into 3 stages according to fundus photography. Eleven patients were genetically confirmed. Fundus autofluorescence, spectral domain optical coherence tomography, and enhanced depth imaging features of BCD were analyzed. Results: On fundus autofluorescence, the abnormal autofluorescence was shown to enlarge in area and decrease in intensity with stages. Using spectral domain optical coherence tomography, the abnormalities in Stage 1 were observed to localize in outer retinal layers, whereas in Stage 2 ...

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    4. Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography

      Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography

      Purpose To evaluate the diagnostic ability of macular ganglion cell and inner plexiform layer measurements in glaucoma, obtained using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) and to compare to circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements. Methods The study included 106 glaucomatous eyes of 80 subjects and 41 eyes of 22 healthy subjects from the Diagnostic Innovations in Glaucoma Study. Macular ganglion cell and inner plexiform layer (mGCIPL), macular ganglion cell complex (mGCC) and cpRNFL thickness were assessed using SS-OCT and SD-OCT, and area under the receiver operating characteristic curves (AUCs) were calculated to ...

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    5. INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING

      INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING

      Purpose: To evaluate microscope-integrated intrasurgical spectral domain optical coherence tomography during macular surgery in a prospective monocenter study. Methods: Before pars plana vitrectomy and before, during, and after membrane peeling, 512 x 128 macular cube scans were performed using a Carl Zeiss Meditec Cirrus high-definition OCT system adapted to the optical pathway of a Zeiss OPMI VISU 200 surgical microscope and compared with retinal staining. Results: The study included 51 patients with epiretinal membranes, with 8 of those having additional lamellar macular holes, 11 patients with vitreomacular traction, and 8 patients with full-thickness macular holes. Intraoperative spectral domain optical coherence ...

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    6. OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy

      OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy

      Purpose To study the precise structural aspects of a type 2 neovascular membrane in a patient with age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography and perform sequential quantitative analysis of the membrane after ranibizumab therapy. Patients and methods Split-spectrum amplitude-decorrelation (SSADA) OCT angiography macular cubes (3 × 3   mm) were acquired with a light source centered at 840   nm, a bandwidth of 45   nm, and an A-scan-rate of 70   000 scans per second. Visible pathologic vessels were outlined manually on average intensity projection en face images, and the area of the lesion and the vessel density were measured ...

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    7. Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Aims Neovascularization is closely associated with plaque progression in non-heart transplantation subjects; on the other hand, cardiac allograft vasculopathy causes unfavourable outcomes. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) can provide microscopic assessment in vivo . The aim of this study was to investigate the impact of neovascularization on intimal proliferation. Methods and results Both IVUS and OCT were attempted in 45 consecutive patients during annual catheterization after heart transplantation. There were 115 vessels [28 vessels were catheterized within 8 weeks of heart transplantation (baseline)]. IVUS analysis assessed vessel, luminal, and intimal (vessel-lumen) volume using Simpson's method. Qualitative parameters ...

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    8. Emerging optical methods for surveillance of Barrett's oesophagus

      Emerging optical methods for surveillance of Barrett's oesophagus

      The rapid rise in incidence of oesophageal adenocarcinoma has motivated the need for improved methods for surveillance of Barrett's oesophagus. Early neoplasia is flat in morphology and patchy in distribution and is difficult to detect with conventional white light endoscopy (WLE). Light offers numerous advantages for rapidly visualising the oesophagus, and advanced optical methods are being developed for wide-field and cross-sectional imaging to guide tissue biopsy and stage early neoplasia, respectively. We review key features of these promising methods and address their potential to improve detection of Barrett's neoplasia. The clinical performance of key advanced imaging technologies is ...

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    9. Symposium: Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls. June 6th 2015, Rome, Italy

      Symposium: Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls.  June 6th 2015, Rome, Italy

      A symposium is scheduled on June 6th in Rome Italy on the Incorporation of OCT Angiography into Clinical Practice, Drug Development and Clinical Trials: Opportunities and Pitfalls. For more information click HERE .

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    10. New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced imaging, today announced that new clinical data relating to its proprietary NvisionVLE ® Imaging System, will be presented in a series of oral and poster presentations during Digestive Disease Week ® (DDW ® ) 2015. The annual meeting will take place May 16-19th in Washington, DC. The schedule for scientific presentations related to advanced optical coherence tomography (OCT) and the NvisionVLE ® Imaging System at DDW 2015 is provided below. SATURDAY, May 16, 2015 Three posters will be presented on Saturday, May 16 at 9:30am in Hall C of Walter ...

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    11. A lotus root-like appearance in carotid stenosis on optical coherence tomography

      A lotus root-like appearance in carotid stenosis on optical coherence tomography

      An 82-year-old man visited the outpatient clinic of our stroke centre because of dizziness. He had a previous history of stroke without definite sequelae. Severe stenosis in the left proximal internal carotid artery (ICA) was seen on Doppler sonography. Conventional angiography revealed focal severe stenosis with ‘string sign’ in the left proximal ICA and delayed distal run off. Optical coherence tomography showed multiple channels surrounding a narrowed central lumen (lotus root-like appearance). Carotid stent placement with a protection device was done without complications. The patient was discharged in good condition 5 days after the procedure.

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    12. Use of Intracoronary imaging in ST Elevation Myocardial Infarction with coronary artery aneurysm and very late stent thrombosis

      Use of Intracoronary imaging in ST Elevation Myocardial Infarction with coronary artery aneurysm and very late stent thrombosis

      The use of Optical Coherence Tomography (OCT)-guided percutaneous coronary intervention (PCI) has been described in ST-Elevation Myocardial Infarction (STEMI) involving relatively simple culprit lesions [1]. Coronary artery aneurysms have a reported incidence of up to 4.9% among coronary angiograms performed and may present clinically as STEMI either from thrombus formation or embolic phenomena [2]. There has been limited experience described regarding the use of OCT in STEMI with an aneurysm in the infarct related artery (IRA).

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    13. Erasmus MC plans to appoint a PhD candidate in the field Intravascular Optical Coherence Tomography (Heartbeat OCT)

      Erasmus MC plans to appoint a PhD candidate in the field Intravascular Optical Coherence Tomography (Heartbeat OCT)

      Job description In the project Heartbeat OCT we will realize a superfast optical imaging system for use in the coronary arteries, the blood vessels around the heart. Patients who get treated after e.g. a heart attack often benefit from intravascular imaging to guide the treatment. Since the heart is a moving organ, slow imaging can cause motion blur, making the imaging less precise. If the imaging is fast enough, it is possible to image an entire artery in the short time between two heart beats, when the heart does not move. In the present project, we will develop the ...

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    14. Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Purpose To describe qualitative characteristics of drusen in eyes with non-advanced age-related macular degeneration (AMD) using polarization-sensitive optical coherence tomography (OCT). Design Cross-sectional study Methods 25 eyes of 25 patients with early to intermediate (non-advanced) AMD were imaged with polarization-sensitive OCT using macular volume scans. All individual drusen in each B-scan were manually delineated by experts certified by a reading center and graded for six different morphological characteristics based on a defined classification scheme, including the presence of internal depolarizing structures and associated depolarizing foci. With the use of a custom-made software, the central B-scan of each individual druse was ...

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    15. Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Introduction Accuracy of intracoronary imaging to discriminate functionally significant coronary stenosis according to vessel diameter remains to be defined. Methods PubMed, Scopus, and Google Scholar were systematically searched for studies assessing diagnostic accuracy (area under the receiver operating characteristic curve [AUC], the primary end point) and sensitivity and specificity (the secondary end points) of minimal luminal area (MLA) or of minimal luminal diameter (MLD) derived from intravascular ultrasound (IVUS) or optical coherence tomography (OCT) to detect functionally significant stenosis as determined with fractional flow reserve (FFR). Results Fifteen studies were included, 2 with 110 patients analyzing only left main (LM ...

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    16. Retinal nerve fiber layer and ganglion cell complex thicknesses measured with spectral-domain optical coherence tomography in eyes with no light perception due to nonglaucomatous optic neuropathy

      Retinal nerve fiber layer and ganglion cell complex thicknesses measured with spectral-domain optical coherence tomography in eyes with no light perception due to nonglaucomatous optic neuropathy

      PURPOSE: To measure retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) in eyes with no light perception due to nonglaucomatous optic neuropathy using spectral-domain optical coherence tomography. METHODS: Fourteen eyes of 14 patients (9 women, 5 men; mean age 56.0 ± 16.6 (standard deviation) years] with no light perception due to optic neuropathy were recruited to this retrospective study. Only clinically stable eyes were included. Eyes were imaged at least 6 months after the onset of the disease. Five patients lost light perception due to traumatic optic neuropathy, four patients had ischemic optic neuropathy, two ...

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    17. Optical coherence tomography assessment of the mechanistic effects of rotational and orbital atherectomy in severely calcified coronary lesions

      Optical coherence tomography assessment of the mechanistic effects of rotational and orbital atherectomy in severely calcified coronary lesions

      Objectives This study sought to assess the mechanistic effect of rotational atherectomy (RA) and orbital atherectomy (OA) on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background RA and OA are two main approaches to ablate coronary calcium. While small case reports have described the mechanistic effect of RA in calcified coronary lesions, there has been no imaging study to assess the effect of OA on coronary artery architecture and/or compare the effects of two atherectomy devices. Methods This study analyzed 20 consecutive patients with OCT imaging performed after atherectomy and after stent implantation ...

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    18. Optical Coherence Tomography for the Identification of a Rare Case of Keratoconus in Albino Donor Cornea

      Optical Coherence Tomography for the Identification of a Rare Case of Keratoconus in Albino Donor Cornea

      Introduction Keratoconus (KC) is a corneal ectatic disorder characterized by irregular corneal surface elevation, interruptions in the Bowman’s layer, stromal thinning and degeneration [1-3]. Irregular astigmatism and myopia can cause severe visual impairment. Oculocutaneous albinism (OCA) is a group of inherited disorders of melanin biosynthesis characterized by a generalized reduction in pigmentation of hair, skin and eyes. The inheritance pattern of albinism is autosomal recessive. Mutations in the tyrosinase [TYR] gene on chromosome 11 q14-q21 are reportedly common in most cases of OCA. The inheritance patterns of keratoconus are more complex than albinism due to the involvement of environmental ...

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    19. Association of Spectral-Domain Optical Coherence Tomography Findings with Visual Outcome of Macula-Off Rhegmatogenous Retinal Detachment Surgery

      Association of Spectral-Domain Optical Coherence Tomography Findings with Visual Outcome of Macula-Off Rhegmatogenous Retinal Detachment Surgery

      Purpose: To identify prognostic factors for the visual outcome for patients with macula-off rhegmatogenous retinal detachment (RRD). Methods: The medical records of 27 patients (27 eyes) with macula-off RRD were retrospectively investigated. In addition to clinical characteristics, spectral-domain optical coherence tomography (SD OCT) images were analyzed. Results: The central foveal thickness at baseline was 923 ± 499.5 µm, and the mean height of the subretinal fluid was 697.8 ± 463.6 µm. Dropout of backreflection at the fovea was detected on preoperative SD OCT in 8 patients (29.6%). The external limiting membrane was disrupted in 5 patients (18.5 ...

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    20. Effects of Retinal Angiography on Optical Coherence Tomography Measurements

      Effects of Retinal Angiography on Optical Coherence Tomography Measurements

      Purpose: To evaluate the effects of retinal angiography, using fluorescein and indocyanine green dyes, on optical coherence tomography (OCT) measurements. Methods: In total, 76 eyes from 76 consecutive patients were included. Macular cube 512 × 128 combination scanning and optic disc 200 × 200 scanning using spectral-domain (SD)-OCT were performed twice, before and after retinal angiography, with fluorescein or indocyanine green. Signal strength, regional retinal thickness of the 9 Early Treatment Diabetic Retinopathy Study subfields, total macular volume, and retinal nerve fiber layer thickness obtained before and after angiography were compared. Repeatability was also investigated. Results: Comparing the results of OCT ...

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    21. Principal Engineer II - Software Opening at Alcon

      Principal Engineer II - Software Opening at Alcon

      Position Description: Provide technical leadership to software design, development, installation and testing solutions needed to achieve proof of concept milestones for Visualization R&D projects. Responsible for the selection, design, implementation, validation, and documentation of algorithms and tools. Will work and collaborate within multidisciplinary teams to achieve project milestones. Alcon is an Equal Opportunity Employer and participacates in E-Verify. As part of the Novartis Group of Companies, Alcon takes pride in maintaining a diverse environment and our policies are not to discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin ...

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    22. Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Received a 2015 NIH Grant for $780,355 for Intracoronary Imaging of Plaque Collagen in Patients. The principal investigator is Seemantini Nadkarni. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The goal of this proposal is to develop and validate an intracoronary imaging device for the assessment of plaque collagen content and architecture in patients. Acute myocardial infarction (AMI), caused by the rupture of unstable plaque, is the leading cause of death worldwide. Collagen and vascular smooth muscle cells (vSMCs) together impart mechanical stability to a plaque, and ...

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    23. NIDEK launches MP-3 Microperimeter

      NIDEK launches MP-3 Microperimeter

      NIDEK CO., LTD., a global leader in the design, manufacture, and distribution of ophthalmic, optometric, and lens edging equipment, is pleased to announce the launch of the MP-3 Microperimeter. Assessment of retinal morphology has advanced significantly due to the introduction of Optical Coherence Tomography into clinical practice. Advances in the functional evaluation of retinal pathology are due to the use of the microperimeter. The MP-3 measures local retinal sensitivity for functional assessment of the retina. The results can be displayed over a color fundus image, correlating retinal anatomy to retinal function. For enhanced clinical assessment, the MP-3 now includes a ...

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