1. All Articles

    25-48 of 14839 « 1 2 3 4 5 ... 617 618 619 »
    1. Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives NIH Grant for The Center for Biomedical OCT Research and Translation

      Massachusetts General Hospital Receives 2014 NIH Grant For $1,449,151 for The Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly ...

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    2. Improving axial resolution in spectral domain low-coherence interferometry through fast Fourier transform harmonic artifacts

      Improving axial resolution in spectral domain low-coherence interferometry through fast Fourier transform harmonic artifacts

      Low-coherence interferometric setups in the Fourier domain can experience false structures after the Fourier transform procedure due to signal saturation; in fact, these structures are located at multiple frequencies of the original signal, also referred to as harmonics. This study aids in a better understanding of this phenomenon. The aim of the present work was to show that these features can be used to improve differential axial resolution in highly reflective samples. Using an optical coherence tomography system and calibrated step height standards, it was possible to achieve a resolution greater than the light source coherence length.

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      Mentions: Marcus P. Raele
    3. Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Purpose: Previously, we have shown that age-related macular degeneration (AMD) influences glaucoma classification with the ganglion cell complex (GCC) parameters of the RTVue-100 optical coherence tomograph (RTVue-OCT) in nonglaucomatous eyes. Now, we reevaluated the influence of AMD on GCC image segmentation and classification for glaucoma on the same eyes, using a new version of the software. Methods: GCC images of nonglaucomatous eyes [30 healthy, 19 with early/intermediate AMD, 16 with subfoveal choroidal neovascularization (CNV), and 19 after intravitreal antiangiogenic treatment of CNV, CNV-anti-VEGF] were reanalyzed with software versions 6.3 (the currently available version) and 6.12 (a version ...

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    4. Three-dimensional speckle reduction in optical coherence tomography through structural guided filtering

      Three-dimensional speckle reduction in optical coherence tomography through structural guided filtering

      Optical coherence tomography (OCT) is a high-resolution noninvasive technology used in medical imaging for the spatial visualization of biological tissue. Due to its coherent nature, OCT suffers from speckle noise, which significantly degrades the information content of resulting scans. We introduce a new filtering method for three-dimensional OCT images, inspired by film grain removal techniques. By matching structural relatedness along all dimensions, the algorithm builds up vector paths for every voxel in the image volume representing its structural neighborhood. Then, by considering the information redundancy along these paths, our filter is able to reduce speckle noise significantly while simultaneously preserving ...

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    5. Automatic tracking of pupillary dynamics from in vivo functional optical coherence tomography images

      Automatic tracking of pupillary dynamics from in vivo functional optical coherence tomography images

      A major challenge currently faced in measuring visually evoked optical changes in different retinal layers using in vivo and non-invasive functional optical coherence tomography (fOCT) is the need for pupillary dilation drugs to enable reliable measurement of the retinal functional responses. However, there are situations where the use of pupillary dilation drugs is not suitable in both clinical and animal ophthalmic research situations. To overcome this challenge, we propose a new approach to tracking visually evoked pupillary dynamics, based on the use of a fast scanning fOCT system and a novel computerised framework, which can then be used to isolate ...

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    6. Choroidal vessel characterization using en-face optical coherence tomography measurement

      Choroidal vessel characterization using en-face optical coherence tomography measurement

      The choroid plays an important role in the pathogenesis of many diseases of the back section of the eye. A comprehensive visualization and knowledge of the choroid is still lacking despite advances in imaging technologies. En-face Optical Coherence Tomography (OCT) provides detailed images useful to understand choroidal vasculature. In the paper, in order to get essential information about circulation-related ocular diseases, an image processing and measurement procedure is presented, capable of providing an efficient choroidal vessel segmentation and caliber estimation starting from en-face OCT images.

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    7. Histology validation of mapping depth-resolved cardiac fiber orientation in fresh mouse heart using optical polarization tractography

      Histology validation of mapping depth-resolved cardiac fiber orientation in fresh mouse heart using optical polarization tractography

      Myofiber organization in cardiac muscle plays an important role in achieving normal mechanical and electrical heart functions. An imaging tool that can reveal microstructural details of myofiber organization is valuable for both basic research and clinical applications. A high-resolution optical polarization tractography (OPT) was recently developed based on Jones matrix optical coherence tomography (JMOCT). In this study, we validated the accuracy of using OPT for measuring depth-resolved fiber orientation in fresh heart samples by comparing directly with histology images. Systematic image processing algorithms were developed to register OPT with histology images. The pixel-wise differences between the two tractographic results were ...

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    8. Preoperative Progression of Macular Holes

      Preoperative Progression of Macular Holes

      Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre- optical coherence tomography era. By observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression. At our institution macular holes are treated in an elective setting. The majority of macular holes undergo a 2-step sequence of phacoemulsification and intraocular lens implantation followed by vitrectomy. We wish to observe the effect of time and cataract surgery on the progression of macular holes prior to vitrectomy.

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    9. Expert evidence on lost profits inadmissible

      Expert evidence on lost profits inadmissible

      The Supreme Judicial Court has upheld a judge’s decision not to allow expert evidence on lost profits in a commercial dispute over optical coherence tomography (OCT) systems used to image human coronary arteries. Superior Court Judge Margaret R. Hinkle excluded opinion testimony from Roy Weinstein, plaintiff LightLab Imaging's expert economist, on the question of future lost...

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    10. Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Background Optical coherence tomography (OCT) is a noninvasive procedure for analysis of retinal morphology. Significant changes in the thickness of the peripapillary retinal nerve fiber layer (RNFL) in Parkinson's disease (PD) have been reported, and the current study was performed to examine whether such changes can also be detected in an animal model of PD. Methods Optical coherence tomography measurements of peripapillary RNFL thickness, macula volume, and foveal thickness were obtained from 10 normal and five 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated cynomolgus monkeys with stable Parkinsonian signs. Results Average RNFL thickness was significantly decreased in Parkinsonian monkeys compared ...

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    11. Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      The bare-metal Tryton Side Branch (SB) Stent™ (Tryton Medical, Durham, NC, USA) is used with a drug-eluting stent (DES) in the main branch (MB) to treat bifurcation lesions. It is argued that a drug-eluting Tryton-version is needed to improve clinical outcomes, although previous registries have shown good clinical results. More insights in neo-intimal hyperplasia (NIH) growth patterns of the Tryton treatment strategy are needed to decide if and where to drug-coat the stent. Ten patients returned for follow-up angiography (mean follow-up time 393 ± 103 days) and optical coherence tomography (OCT) pullbacks from the MB were obtained in all patients and ...

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    12. Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer

      Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer

      We present a newly developed single mode fiber based swept source polarization sensitive optical coherence tomography system using a single input state at 1040 nm. Two non-polarizing fiber based beam splitters are combined to form a Mach-Zehnder interferometer, while two polarizing beam splitters are used to obtain a polarization sensitive detection. Both types of beam splitters solely feature conventional single mode fibers. Polarization control paddles are used to set and maintain the polarization states in the fibers of the interferometer and detection unit. By use of a special paddle alignment scheme we are able to eliminate any bulk optic wave ...

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    13. The Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy (PIONEER) Study: 2-year Results

      The Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy (PIONEER) Study: 2-year Results

      Purpose To evaluate the feasibility, safety, and utility of intraoperative optical coherence tomography (OCT) for use during ophthalmic surgery. Design Prospective, consecutive, case series Methods A prospective, single-center, consecutive, case series was initiated to assess intraoperative OCT in ophthalmic surgery. Intraoperative scanning was performed with a microscope mounted spectral domain OCT system. Disease specific or procedure-specific imaging protocols (e.g., scan type, pattern, size, orientation, density) were utilized for anterior and posterior segment applications. A surgeon feedback form was recorded as part of the study protocol to answer specific questions regarding intraoperative OCT utility immediately after the surgical procedure was ...

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    14. Intravascular Photoacoustic Tomography of Coronary Atherosclerosis

      Intravascular Photoacoustic Tomography of Coronary Atherosclerosis

      The emergence of coronary angiography in the late 1950s enabled an imaging-based understanding of coronary artery disease and led to surgical and intravascular treatment approaches of coronary luminal stenosis. Based on the increasing familiarity with intracoronary catheter manipulation, miniature intravascular ultrasound probes subsequently were developed. The advantage of direct, intraluminal imaging was initially considered to be its capability to clarify indeterminate luminal findings (e.g., severity of left main stenosis, dissection, in-stent restenosis). However, investigators soon realized that the visualization of the wall/plaque beyond the narrowed lumen with intravascular imaging provided important insights into pathophysiologic aspects of atherosclerosis ( 1 ...

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      Mentions: Cleveland Clinic
    15. Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Optical coherence tomography (OCT) is a high-resolution technology for imaging of biological tissues that has shown tremendous potential for intracoronary use. Based on near-infrared light rather than ultrasound, catheter-based OCT provides cross-sectional images of the vessel wall and related devices in a histology-like manner. At present, OCT is primarily being used in research to better characterize and understand the pathophysiology of vulnerable plaques and to study the acute and long-term effects of coronary stent implantation. The present review provides the interventional cardiologist with a summary of the clinical research involving OCT, with an emphasis on specific challenges and how these ...

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      Mentions: Maria D. Radu
    16. Optical coherence tomography applied to tests of skin care products in humans – a case study

      Optical coherence tomography applied to tests of skin care products in humans – a case study

      Background/purpose When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. Methods We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of ...

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      Mentions: Marcus P. Raele
    17. Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for the corneal thicknesses of the entire cornea in different stages of keratoconus.

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    18. Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) are cross-sectional, noncontact, highresolution diagnostic modalities for posterior and anterior segment (AS) imaging.The AS-OCT provides tomographic imaging of the cornea, iris, lens, and anterior chamber (AC) angle in several ophthalmic diseases. In glaucoma, AS-OCT is utilized to evaluate the morphology of AS structures involved in the pathogenesis of the disease, to obtain morphometric measures of the AC, to evaluate the suitability for laser or surgical approaches, and to assess modifications after treatment. In patients undergoing surgery, AS-OCT is crucial in the evaluation of the filtering bleb functionality, permitting ...

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    19. OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      Purpose: To demonstrate the ability to monitor geographic atrophy (GA) volumetrically through all retinal layers with high-resolution optical coherence tomography difference maps and average macular volume. Methods: Observational case report. Results: Two patients diagnosed with GA were followed up for multiple years with consecutive high-resolution optical coherence tomography studies along with fundus photography and fluorescein angiography or fundus autofluorescence. Difference maps visually reflect macular thinning associated with expansion of GA witnessed on alternative studies. In addition, these maps show progressive macular thinning within previously delineated areas of GA. Average macular volume quantitatively demonstrates the decreasing volume associated with the expanding ...

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    20. Optical Coherence Tomography in Coronary Artery Disease: Toward Sub cellular Imaging

      Optical Coherence Tomography in Coronary Artery  Disease: Toward Sub cellular Imaging

      Intracoronary optical coherence tomography (OCT) is an interferometric imaging technology that uses near-infrared light to provide cross-sectional images with an axial resolution of 10 μm and a transverse of 20-40 μm in vivo. The imaging capabilities of OCT have enabled visualization of important features of coronary plaque, including thrombus, macrophage, neovascularization, stent implantation and stent strut coverage, which have provided new insights for better understanding of this disease. Frequency domain (FD)-OCT is secondgeneration form of OCT that is able to acquire OCT images at a much higher frame. The high-speed imaging capabilities of FD-OCT have made intravascular OCT practical ...

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    21. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    22. Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include ...

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    23. Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Importance Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. Objective To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert retinal thickness measurements from SD-OCT to equivalent values on TD-OCT. Design, Setting, and Participants A cross-sectional observational study was conducted in private and institutional practices. Persons with diabetes mellitus who had at least 1 eye with central-involved diabetic macular ...

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    25-48 of 14839 « 1 2 3 4 5 ... 617 618 619 »
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