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1. Early vascular healing with biodegradable polymer coated sirolimus-eluting coronary stent implantation: assessed by optical coherence tomography results at 4-month follow-up

   Explore Edizioni Minerva Medica May 19 2013 Cardiology

   

   Aim: The aim of this study was to evaluate the strut apposition and neointimal coverage of Supralimus-Core stent struts at 4 months after implantation using optical coherence tomography (OCT). Methods: The Supralimus-Core OCT study is a retrospective, single-center study evaluating strut apposition and neointimal coverage with OCT at 4 months after stent implantation. A total of 12 patients, who had 15 stents implanted were included in the study. The OCT was obtained using a C7-XR FD-OCT (frequency-domain OCT) intravascular imaging system. Strut apposition, neointimal hyperplasia (NIH) thickness and stent coverage on each stent strut were evaluated. Results: A total of ...

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   Mentions: National Institutes of Health Lightlab C7 XR OCT Imaging System St. Jude Medical

2. Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

   Explore Journal of Cardiology May 19 2013 Cardiology

   

   Background Distal embolization during percutaneous coronary intervention (PCI) may deteriorate microvascular reperfusion in patients with ST-elevation myocardial infarction (STEMI). Reperfusion at the coronary microvascular level is important for STEMI and culprit plaque is associated with distal embolization and microvascular reperfusion. ST-segment resolution (ST-R) in the electrocardiogram reflects microvascular reperfusion after primary PCI. Longitudinal extent of lipid pool assessed by optical coherence tomography (OCT) may predict the risk of failure of microvascular reperfusion after primary PCI. Methods and results This study consisted of 39 patients with STEMI who underwent primary PCI within 24 h after the onset of chest pain. Immediately ...

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3. First International En Face OCT Congress in Rome December 14 2013

   Explore Optical Coherence Tomography News May 18 2013

   

   The First international meeting on “en face”OCT in Rome Saturday December 14. Co-organizers are Bruno Lumbroso (Rome) Philip Rosenfeld (Miami) and Gabriel Coscas (Paris). Duration one day. We will discuss next developments of clinical “en face” OCT and clinical applications of this technique. For more information click HERE . Meeting Site ( www.symposiacongressi.eu and secretariat anna.porro@symposiacongressi.eu )).

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   Mentions: Philip J. Rosenfeld Gabriel J. Coscas University of Miami

4. Global OCT imaging market: $645 million industry by 2012

   Explore Market Research Reports May 17 2013 Other Business News

   

   The global OCT imaging market (optical coherence tomography) is suggested to have reached a value of around $525.7 million in 2010, and is believed to have then grown to a total of $645.4 million by the end of 2012. Optical coherence tomography (OCT) is a relatively new technology for performing high-resolution, cross-sectional imaging of tissue structure on the micron scale in situ and in real time. OCT has emerged as a powerful optical imaging instrument and technology. OCT performs high-resolution, cross-sectional tomographic imaging of the internal structure in 3-D materials, including biological tissues. The features of OCT that ...

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   Mentions: FDA

5. St. Jude Medical Announces European Approval of 3-D Vessel Reconstruction Technology to Aid Physicians in Stent Placement

   Explore Optical Coherence Tomography News May 17 2013 Cardiology

   

   St. Jude Press Release - St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced CE Mark approval of its ILUMIEN™ OPTIS™ PCI Optimization System™, a new technology designed to provide physicians with a comprehensive disease assessment tool for treating patients with coronary artery disease (CAD). The system will be on display for the first time in Europe during EuroPCR. 3-D image of a stent inside a coronary artery taken using the ILUMIEN(TM) OPTIS(TM) (Photo: St. Jude Medical, Inc.) The ILUMIEN OPTIS system provides enhancements to the ILUMIEN ™ system, including first-of-its-kind stent planning software tools to ...

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   Mentions: Giulio Guagliumi St. Jude Medical Frank J. Callaghan

6. Influence of Cataract Surgery on Optical Coherence Tomography and Neurophysiology Measurements in Patients With Retinitis Pigmentosa

   Explore American Journal of Ophthalmology May 17 2013 Ophthalmology

   

   Purpose To evaluate the effect of uncomplicated cataract phacoemulsification on the measurements of visual evoked potentials (VEP), pattern electroretinogram (PERG), and macular and retinal nerve fiber layer (RNFL) using 2 spectral-domain optical coherence tomography (OCT) instruments, the Cirrus OCT (Carl Zeiss Meditech) and Spectralis OCT (Heidelberg Engineering), in patients with retinitis pigmentosa (RP), and to assess the reliability of the OCT measurements before and after cataract surgery. Design Observational cross-sectional study. Methods Thirty-five eyes of 35 patients with RP (20 men and 15 women, 45-66 years) who underwent cataract phacoemulsification were studied. At 1 month before and 1 month after ...

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   Mentions: Heidelberg Engineering Carl Zeiss Meditec Miguel Servet University Hospital

7. Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

   Explore Healio.com May 17 2013 Ophthalmology

   

   BACKGROUND AND OBJECTIVE: To analyze choroidal morphology and vascular layers in eyes with retinitis pigmentosa (RP) using spectral-domain optical coherence tomography. PATIENTS AND METHODS: Cross-sectional, retrospective analysis of 14 patients (14 eyes) with RP and 33 healthy subjects (33 eyes) who underwent high-definition one-line raster scanning at a single center. Two independent raters evaluated the morphology, thickness, and vascular layers of the choroid in both groups. RESULTS: The choroid had an irregular shape in 11 of 14 eyes (79%) with RP. The thickest point of choroid was not subfoveal as in healthy eyes, and exaggerated nasal thinning of the choroid ...

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   Mentions: Optovue Jay S. Duker University of São Paulo

8. Congenital Hypertrophy of the Retinal Pigment Epithelium: Choroidal Cavitation Demonstrated on Spectral-Domain OCT

   Explore Healio.com May 17 2013 Ophthalmology

   

   A patient with solitary congenital hypertrophy of the retinal pigment epithelium demonstrated a striking choroidal cavitation on spectral-domain optical coherence tomography (OCT). Although photoreceptor atrophy overlying congenital hypertrophy of the retinal pigment epithelium has been described on time-domain OCT, this patient manifested a previously unrecognized tomographic feature.

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9. Inter-Scan Reproducibility of Geometric Coronary Artery Measurements Using Frequency-Domain Optical Coherence Tomography

   Explore jstage.jst.go.jp May 17 2013 Cardiology

   

   Frequency-domain optical coherence tomography (FD-OCT) is a novel technology which provides high-resolution cross-sectional images of coronary arteries. The aim of this study was to evaluate the inter-scan reproducibility of geometric FD-OCT measurements in the clinical setting. We examined 20 coronary lesions using FD-OCT. Following the FD-OCT image acquisition (1 st pullback), and after the disengagement and re-engagement of the guiding catheter, an additional acquisition (2 nd pullback) was performed using a new FD-OCT catheter. There was excellent correlation for minimum lumen area ( r = 0.99, P < 0.001), lesion length ( r = 0.99, P < 0.001) and lumen volume ( r ...

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   Mentions: Wakayama Medical University Takashi Kubo Takashi Tanimoto

10. High-Definition Optical Coherence Tomography (HD-OCT)

    Explore Agfa HealthCare — May 17 2013 Dermatology , Oncology

    

    Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...

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    Mentions: AGFA Healthcare AGFA SKINTELL

11. Multimodal Imaging of Optic Disc Drusen

    Explore American Journal of Ophthalmology May 17 2013 Ophthalmology

    

    Purpose To evaluate optic disc drusen, extracellular protein deposits known to contain numerous aggregates of mitochondria, using multimodal modalities featuring optical coherence tomography (OCT) and autofluorescence imaging. Design Retrospective observational case series. Methods Eyes with optic nerve drusen were examined with enhanced depth imaging (EDI)-OCT, swept source OCT, and fundus autofluorescence using a fundus camera. Results Twenty-six eyes of 15 patients with optic disc drusen were evaluated. EDI-OCT and swept source OCT showed multiple optic disc drusen at different levels; most were located immediately anterior to the lamina cribrosa. The drusen were ovoid regions of lower reflectivity that were ...

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    Mentions: Richard F. Spaide

12. Visible-light optical coherence tomography for retinal oximetry

    Explore opticsinfobase.org May 16 2013

    

    We applied a visible-light spectroscopic optical coherence tomography (vis-OCT) for in vivo retinal oximetry. To extract hemoglobin oxygen saturation (sO2) in individual retinal vessels, we established a comprehensive analytical model to describe optical absorption, optical scattering, and blood cell packing factor in the whole blood and fit the acquired vis-OCT signals from the bottom of each imaged vessel. We found that averaged sO2 values in arterial and venous bloods were 95% and 72%, respectively.

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    Mentions: Northwestern University Vadim Backman Ji Yi

13. Single-shot speckle reduction and dispersion compensation in optical coherence tomography by compounding fractional Fourier domains

    Explore opticsinfobase.org May 16 2013

    

    We present speckle suppression and dispersion compensation for Fourier-domain optical coherence tomography based on fractional Fourier transforms of a single A scan. A 1.54-fold reduction in speckle contrast was achieved with group velocity dispersion compensation. The method is demonstrated on biological samples using a swept source configuration at 1310 nm and a spectral-domain system at 840 nm

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    Mentions: University of Auckland Frederique Vanholsbeeck

14. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

    Explore Home May 16 2013

    

    Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at days 7 and 21 after implantation and post mortem on the day of noticeable inflammation. A Fourier-domain OCT was programmed for spoke pattern scanning schemes centered at the implant midpoint ...

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    Mentions: Alexander Krüger University of Hannover Laser Zentrum Hannover

15. NinePoint Medical launches esophageal imaging system

    Explore bizjournals May 16 2013 Gastroenterology , Other Business News

    

    Cambridge medical device company NinePoint Medical Inc. on Thursday launched its lead product in the U.S., an imaging system that makes it easier to examine and detect diseases of the esophagus. NinePoint’s proprietary NvisionVLE Imaging System was granted 510(k) clearance in December 2011 to be used as an imaging tool in the evaluation of human tissue microstructure. Last month, it received additional clearance to to include imaging of esophageal tissue microstructure. In June 2012, the device received European CE mark approval .

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    Mentions: Massachusetts General Hospital NinePoint Medical

16. Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma

    Explore Wiley Online Library May 16 2013 Dermatology

    

    We read with interest two recent studies which established that High Definition Optical Coherent Tomography (HD-OCT), a newly released skin imaging technique, facilitates the in vivo diagnosis of non-melanoma skin cancers (1, 2). However, to the best of our knowledge there is no data available regarding HD-OCT and melanoma. A 61-year-old man, skin type II, with a previous history of melanoma 10 years before consulted for a follow-up visit. Clinical and dermoscopic examination pointed to two suspicious pigmented lesions in the right pectoral region and on the left scapula. RCM examination using a commercially available VivaScope ® 1500 (Lucid-Tech Inc., Henrietta ...

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    Mentions: AGFA Healthcare AGFA SKINTELL

17. Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography

    Explore Home - Springer May 16 2013 Otolaryngology

    

    The full-field thickness distribution, three-dimensional surface model and general morphological data of six human tympanic membranes are presented. Cross-sectional images were taken perpendicular through the membranes using a high-resolution optical coherence tomography setup. Five normal membranes and one membrane containing a pathological site are included in this study. The thickness varies strongly across each membrane, and a great deal of inter-specimen variability can be seen in the measurement results, though all membranes show similar features in their respective relative thickness distributions. Mean thickness values across the pars tensa ranged between 79 and 97 μm; all membranes were thinnest in the ...

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    Mentions: Adrian G. Podoleanu University of Kent Adrian Bradu

18. Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers

    Explore Nature Publishing Group May 16 2013 Tunable Sources

    

    Ultrafast lasers have a crucial function in many fields of science; however, up to now, high-energy pulses directly from compact, efficient and low-power semiconductor lasers are not available. Therefore, we introduce a new approach based on temporal compression of the continuous-wave, wavelength-swept output of Fourier domain mode-locked lasers, where a narrowband optical filter is tuned synchronously to the round-trip time of light in a kilometre-long laser cavity. So far, these rapidly swept lasers enabled orders-of-magnitude speed increase in optical coherence tomography. Here we report on the generation of ~60-70 ps pulses at 390 kHz repetition rate. As energy is stored ...

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    Mentions: Robert A. Huber Wolfgang Wieser Thomas Klein

19. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance

    Explore LWW Online May 16 2013 Gastroenterology , Oncology

    

    Purpose of review: This article reviews reports on the prevalence of subsquamous intestinal metaplasia (SSIM) in patients with Barrett's esophagus, and the implications of SSIM in the neoplastic progression of Barrett's esophagus to esophageal adenocarcinoma. Recent findings: Endoscopic eradication therapy for dysplastic Barrett's esophagus has become an encouraging alternative to esophagectomy or continued endoscopic surveillance. However, the presence of SSIM before and after ablation is concerning because this tissue may have potential for malignant progression, is not visible by conventional endoscopy, and may evade detection by random esophageal biopsy sampling methods. Advances in endoscopic high-resolution three-dimensional optical ...

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    Mentions: Harvard University Hiroshi Mashimo

20. From the epicardial adipose tissue to vulnerable coronary plaques

    Explore World J. Gastroenterology May 16 2013 Cardiology

    

    Thin cap fibroatheromas (TCFAs) are the most common underlying substrate in patients suffering acute coronary thrombotic events. Recently, an interesting association between TCFAs and a particular depot of visceral fat called epicardial adipose tissue has been suggested. In this study, we review some basic and clinical aspects of behind this interesting association as well as the value of optical coherence tomography in the diagnosis of TCFAs.

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    Mentions: San Carlos University Hospital Fernando Alfonso

21. NinePoint Medical Announces U.S. Commercial Availability of the NvisionVLE™ Imaging System

    Explore Optical Coherence Tomography News May 16 2013 Gastroenterology , Other Business News

    

    NinePoint Press Release - NinePoint Medical, Inc., an emerging leader in the development of medical devices for advanced optical imaging, today announced the commercial launch of its proprietary NvisionVLE ™ Imaging System in the United States. In addition, NinePoint today announced the launch of its newly redesigned website, www.ninepointmedical.com . In December 2011, the NvisionVLE Imaging System received 510(k) clearance from the U.S. Food and Drug Administration for use as an imaging tool in the evaluation of human tissue microstructure by providing two-dimensional, cross sectional, real-time depth visualization. Last month, NinePoint received 510(k) clearance to expand the System ...

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    Mentions: Massachusetts General Hospital FDA NinePoint Medical

22. Optical Molecular Imaging in the Gastrointestinal Tract

    Explore giendo.theclinics.com May 15 2013 Gastroenterology

    

    Recent developments in optical molecular imaging allow for real-time identification of morphologic and biochemical changes in tissue associated with gastrointestinal neoplasia. This review summarizes widefield and high-resolution imaging modalities in preclinical and clinical evaluation for the detection of colorectal cancer and esophageal cancer. Widefield techniques discussed include high-definition white light endoscopy, narrow band imaging, autofluoresence imaging, and chromoendoscopy; high-resolution techniques discussed include probe-based confocal laser endomicroscopy, high-resolution microendoscopy, and optical coherence tomography. New approaches to enhance image contrast using vital dyes and molecular-specific targeted contrast agents are evaluated.

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    Mentions: Rebecca Richards-Kortum Rice University

23. OCT imaging market led by Carl Zeiss and St. Jude Medical

    Explore uk.finance.yahoo.com May 15 2013 Other Business News

    

    The optical coherence tomography imaging market (OCT) is estimated to have reached a valuation of $645.4 million by the end of 2012, increasing from approximately $525.7 million in 2010. Optical coherence tomography is an optical signal acquisition and processing method. It captures micrometer-resolution, three-dimensional images from within optical scattering media (e.g., biological tissue). Optical coherence tomography is an interferometric technique, typically employing near-infrared light. The use of relatively long wavelength light allows it to penetrate into the scattering medium. OCT is widely accepted for clinical diagnostics in ophthalmology, dentistry, cardiology, dermatology and also has broadened its application ...

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    Mentions: Carl Zeiss Meditec St. Jude Medical

24. Choroidal Thickness Measurement in Myopic Eyes by Enhanced Depth Optical Coherence Tomography

    Explore Ophthalmology May 15 2013 Ophthalmology

    

    Purpose To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI). Design A cross-sectional study. Participants Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated. Methods Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm ...

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    Mentions: Sun Yat-Sen University Dennis S. C. Lam The Chinese University of Hong Kong

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