1. All Articles

    25-48 of 17343 « 1 2 3 4 5 ... 721 722 723 »
    1. Relationship between Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography and Visual Field Severity Indices

      Relationship between Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography and Visual Field Severity Indices

      Purpose Though there are many reports regarding the structure-function relationship in glaucoma, they are too complicated to apply to the routine clinical setting. The aim of this study was to investigate the direct relationship between peripapillary retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual field (VF) severity indices computed by standard automated perimetry. Methods This cross-sectional comparative study included 104 glaucomatous patients and 59 healthy subjects. Peripapillary RNFL thickness was measured by spectral domain (SD) and time domain (TD) OCTs. Four glaucoma VF severity indices, including mean deviation (MD), pattern standard deviation (PSD), Collaborative ...

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    2. Three-Dimensional Morphometric Analysis of the Iris by Swept-Source Anterior Segment Optical Coherence Tomography in a Caucasian Population

      Three-Dimensional Morphometric Analysis of the Iris by Swept-Source Anterior Segment Optical Coherence Tomography in a Caucasian Population

      Purpose : We analyzed by swept-source anterior segment optical coherence tomography (SS-ASOCT) the three-dimensional iris morphology in a Caucasian population, and correlated the findings with iris color, iris sectors, subject age, and sex. Methods : One eye each from consecutive healthy emmetropic (refractive spherical equivalent ±3 diopters) volunteers were selected for the study. The enrolled eye underwent standardized anterior segment photography to assess iris color. Iris images were assessed by SS-ASOCT for volume, thickness, width, and pupil size. Sectoral variations of morphometric data among the superior, nasal, inferior, and temporal sectors were recorded. Results : A total of 135 eyes from 57 males ...

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    3. Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema

      Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema

      Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo , we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for the statistical decision task. Resulting from this, the receiver operating characteristic (ROC) curves for the diagnosis of airway edema with full-range OCT in-vivo images were extracted and areas under ROC ...

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    4. Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin

      Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin

      We have developed ultraviolet (UV)- and visible-light one-shot spectral domain (SD) optical coherence tomography (OCT) that enables in situ imaging of human skin with an arbitrary wavelength in the UV–visible-light region (370–800 nm). We alleviated the computational burden for each color OCT image by physically dispersing the irradiating light with a color filter. The system consists of SD-OCT with multicylindrical lenses; thus, mechanical scanning of the mirror or stage is unnecessary to obtain an OCT image. Therefore, only a few dozens of milliseconds are necessary to obtain single-image data. We acquired OCT images of one subject’s skin ...

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    5. Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

      Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

      Background Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation of deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations of wall apposition from either high-resolution contrast-enhanced cone-beam CT (VasoCT) or intravascular optical coherence tomography (OCT) images. Methods VasoCT and OCT images were obtained after FD implant (n=8 aneurysms) in an experimental sidewall aneurysm model in canines. Surface models of the vessel wall and FD device were extracted, and the distance between them was presented on a two-dimensional flattened ...

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    6. Evaluation of the peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer measurements in patients with iron deficiency anemia with optical coherence tomography

      Evaluation of the peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer measurements in patients with iron deficiency anemia with optical coherence tomography

      Objective : To evaluate the thickness of the peripapillary retinal fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCL+) using optical coherence tomography (OCT) in patients with iron deficiency (ID) anemia. Methods : This study included 73 eyes of 39 patients with ID anemia and 68 eyes of 34 age- and sex-matched healthy subjects. The measurements included the peripapillary RNFL thicknesses as average, 4 quadrant and 12 clock-hour (CH) based and macula GCL+ thicknesses as average and 6 quadrant based. All measurements were completed with Cirrus HD-OCT and the results were compared between the groups. Results : A total of 73 eyes ...

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    7. Foveal microanatomy documented by SD-OCT following treatment of advanced retinoblastoma

      Foveal microanatomy documented by SD-OCT following treatment of advanced retinoblastoma

      Progress in the treatment of retinoblastoma has greatly improved patient survival and globe salvage rates. The introduction of intraoperative spectral domain optical coherence tomography (OCT) allows visualization of foveal anatomy and microstructure to predict visual potential and facilitate planning for visual rehabilitation. Eyes with total retinal detachments secondary to exophytic retinoblastoma have OCT findings of absence or disruption of the external limiting membrane and ellipsoid layers. We document the evolution of foveal microanatomy reconstitution following the use of chemotherapy in a 1-year-old boy and illustrate the restoration of the external limiting membrane and ellipsoid layer, thus achieving normal foveal microanatomy.

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    8. Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      In June 2015, microscopy and imaging systems company Leica Microsystems acquired Bioptigen Inc., a company born from Duke's Pratt School of Engineering. Formed in 2004, Bioptigen has become a leader in optical coherence tomography (OCT), an imaging technique that uses light to capture extremely high-resolution, three-dimensional pictures of the eye. Bioptigen was the brainchild of Duke’s Michael J. Fitzpatrick Professor of Engineering Joseph Izatt and CEO Eric Buckland. Since its launch, the company secured more than 60 issued patents in OCT technology, many of which were licensed from intellectual property developed by Izatt, his students, and collaborators at ...

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    9. SD-OCT Angiography

      SD-OCT Angiography

      The objective of this study is to image retinal vascular alterations in patients with retinal disease using the AngioVue OCT-A system and understand the information these images provide. The investigators will image study participants who have retinal diseases with the AngioVue unit (Optovue) and will collect relevant clinical data to understand the nature of the information contained in images obtained on AngioVue. This study being conducted under an abbreviated IDE. The investigators will analyze data using descriptive statistics. Risks related to light exposure will be managed by ensuring that the exposure to the AngioVue light source is well below maximum ...

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    10. Optical frequency domain imaging with a rapidly swept laser in the 1300nm bio-imaging window

      Optical frequency domain imaging with a rapidly swept laser in the 1300nm bio-imaging window

      Optical frequency domain imaging system (OFDI) in the 1300nm biological imaging window is demonstrated by using a high speed frequency swept laser source. The output of the laser with central wave length of 1320nm is continuously tuned over a bandwidth of 100nm with a repetition rate of 16 KHz. The laser source has an instantaneous coherence length of 6mm and delivers an average power of 12mW. Axial resolution ~ 6μm in the biological tissue and peak sensitivity of 110dB are achieved. The experimentally determined values of the imaging parameters such as the axial resolution, sensitivity and depth range are found ...

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    11. En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      We tested and compared the capability of multiple optical coherence tomography (OCT) angiography methods: phase variance, amplitude decorrelation and speckle variance, with application of the split spectrum technique, to image the choroiretinal complex of the human eye. To test the possibility of OCT imaging stability improvement we utilized a real-time tracking scanning laser ophthalmoscopy (TSLO) system combined with a swept source OCT setup. In addition, we implemented a post- processing volume averaging method for improved angiographic image quality and reduction of motion artifacts. The OCT system operated at the central wavelength of 1040nm to enable sufficient depth penetration into the ...

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    12. University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      The University of Alabama at Birmingham Receives a 2015 NIH Grant for $498,330 to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT. The principal investigator is Steven Mark Rowe. The program began in 2012 and elndsi nin 2016. Below is a summary of the proposed work. Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an anion transporter of chloride and bicarbonate. Defective or deficient CFTR leads to severe mucoobstructive lung disease and severe morbidity and early mortality due to lung infections. Even though substantial advances in ...

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    13. Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Endoscopic diagnosis with histological evidence is necessary to decide the best strategy for treating esophageal squamous cell carcinoma and Barrett’s-associated neoplasia, and the recent development of endoscopic technologies have made possible real-time information of malignant hallmarks. We focused on the development of optical coherence tomography (OCT), the only technology that can depict real-time cross-sectional images with high resolution. With the improvements in image resolution, acquisition rate and demonstrable area of three-dimensional devices with Doppler capability, OCT imaging was shown to enable visualization of structural/ functional alterations in the mucosal/submucosal tissue of the esophagus, resulting in more accurate preoperative ...

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    14. Reflection, phase and en -face sectional imaging of scattering objects using quasi-single-shot wide-field optical coherence tomography

      Reflection, phase and en -face sectional imaging of scattering objects using quasi-single-shot wide-field optical coherence tomography

      We report a quasi-single-shot wide-field optical coherence tomography system that enables to measure the reflection, phase and en - face OCT images from the same setup using the glass jig. The jig consisting of a wedge glass substrate and a glue dot is contacted to the tissue surfaces, and the data within glue dot is used to reduce the phase noise of the interference signal. The reconstructed image size of the object was 4.0 mm × 4.3 mm. The standard deviation (STD) of the phase variation was minimized by 54 % and obtained to be 0.027 rad for the poke ...

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    15. Effects of Refractive Power on Macular Thickness Measurement Using Spectral-Domain Optical Coherence Tomography

      Effects of Refractive Power on Macular Thickness Measurement Using Spectral-Domain Optical Coherence Tomography

      Purpose: To investigate the effects of refractive power on macular thickness measurements by spectral-domain optical coherence tomography (SD-OCT). Subjects and Methods: For this prospective cohort study, a total of 50 eyes from 50 normal subjects with no systemic or ocular disease and no history of ocular surgery were studied from February 2014 to May 2014. We used soft contact lenses with a wide range of diopters to change the refractive power. The macular thickness of uncorrected eyes without contact lenses was measured by SD-OCT, and we compared the findings with the results of subsequent investigations in which macular thickness was ...

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    16. Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography (Thesis)

      Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography (Thesis)

      Optical Coherence Tomography (OCT) is an emerging optical imaging modality that is capable of imaging biological tissues with micron resolution and millimeter penetration depth. In clinical diagnostic imaging and pathology, OCT has helped fill a gap in terms of both resolution and imaging depth, in between traditional fluoroescence based microscopes and non-invasive organ level imaging. In this domain, OCT can be used both as an ex vivo pathological examination tool or in vivo imaging modality.OCT has been successful in ophthalmology owing to its excellent in vivo optical sectioning ability and penetration depth. Over the years, OCT has seen substantial ...

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    17. Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients

      Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients

      Purpose . To evaluate the role of spectral-domain optical coherence tomography (SD-OCT) in early detection of Chloroquine maculopathy in rheumatoid arthritis (RA) patients. Methods . 40 left eyes of 40 female rheumatoid arthritis patients who received treatment chloroquine for more than one year were recruited in the study. All patients had no symptoms or signs of Chloroquine retinopathy. They were evaluated using SD-OCT, where the Central Foveal Thickness (CFT), parafoveal thickness and perifoveal thickness, average Retinal Nerve Fiber Layer (RNFL) thickness, and Ganglion Cell Complex (GCC) measurements were measured and compared to 40 left eyes of 40 normal females. Results . The mean ...

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    18. Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease

      Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease

      Purpose : To develop and apply an objective algorithm for analyzing outer retinal layers imaged by spectral-domain optical coherence tomography (SD-OCT) in patients with Stargardt disease (STGD1). Methods : Horizontal macular B-scans were acquired from 20 visually normal controls and 20 genetically confirmed stage 1 STGD1 patients. The number of outer retinal bands was quantified using a semiautomated algorithm that detected bands using the second derivative of longitudinal reflectivity profiles. The present analysis focused on the three outermost bands, currently associated with the ellipsoid zone (EZ), cone outer segment interdigitation zone (IZ), and retinal pigment epithelium (RPE) complex. Results : The RPE complex ...

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    19. Phase-resolved Doppler Optical Coherence Tomographic features in Retinal Angiomatous Proliferation

      Phase-resolved Doppler Optical Coherence Tomographic features in Retinal Angiomatous Proliferation

      Purpose To study patients diagnosed with retinal angiomatous proliferation (RAP) based on conventional imaging techniques with phase-resolved Doppler optical coherence tomography (OCT) to detect and localize blood flow in RAP lesions and to compare these findings to conventional imaging, which are mostly invasive and give limited information concerning intra- and transretinal blood flow. Design Single-center, consecutive observational case series. Methods Twelve treatment-naïve patients diagnosed with RAP based on fundus examination, fluorescein and indocyanine-green angiography, were included. Median age was 79 years (range 65-90). Patients were imaged with an experimental 1040 nm swept-source phase-resolved Doppler-OCT instrument. Abnormal flow was defined ...

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    20. Age, Gender and Ethnic Variations in Inner and Outer Retinal and Choroidal Thickness on Spectral Domain Optical Coherence Tomography

      Age, Gender and Ethnic Variations in Inner and Outer Retinal and Choroidal Thickness on Spectral Domain Optical Coherence Tomography

      Purpose To evaluate age, gender and ethnic variations in inner and outer retinal and choroidal thickness and foveal pit, using spectral-domain optical coherence tomography (SD-OCT). Design Single-center observational cross-sectional study. Methods Ninety randomly selected, healthy individuals of White, Black and South Asian origin underwent SD-OCT (Spectralis HRA+OCT, Heidelberg engineering, Germany) raster and enhanced-depth imaging scan. Manual measurements of inner and outer retinal thickness and choroidal thickness up to 3mm nasal and temporal to the fovea were performed. The age, gender and ethnic differences in these parameters were analyzed. Results The mean inner retinal thickness was lower by approximately 12 ...

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    21. Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Coronary atherosclerosis continues to be major cause of death in the developed world ( (1) ). Although we have known for at least a century that fissures and ruptures of coronary arteries are the cause of coronary thrombosis and, in the last 2 decades, that plaque erosion and calcified nodule are additional causes of thrombosis, our ability to use this knowledge in a real-time fashion to affect the treatment of patients with acute coronary syndromes (ACS) has been limited ( (2) ). Although angiography-guided percutaneous coronary intervention (PCI) has become the standard of care for treatment of ACS, it provides little understanding of culprit ...

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      Mentions: Emory University
    22. Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Subglottic edema and acquired subglottic stenosis are potentially airway -compromising sequelae in neonates following endotracheal intubation . At present, no imaging modality is capable of in vivo diagnosis of subepithelial airway wall pathology as signs of intubation - related injury . OBJECTIVES: To use Fourier domain long - range optical coherence tomography (LR-OCT) to acquire micrometer-resolution images of the airway wall of intubated neonates in a neonatal intensive care unit (NICU) setting and to analyze images for histopathology and airway wall thickness. METHODS: LR-OCT of the neonatal laryngotracheal airway was performed a total of 94 times on 72 subjects (age 1-175 days, total intubation ...

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    23. Optical coherence tomography detects structural abnormalities of the nasal mucosa in patients with cystic fibrosis

      Optical coherence tomography detects structural abnormalities of the nasal mucosa in patients with cystic fibrosis

      Background Chronic inflammation and remodeling of the airways remain a hallmark of cystic fibrosis (CF). However, knowledge of the associated mucosal micro-anatomical changes is limited. We evaluated the potential of optical coherence tomography (OCT) for in vivo imaging of the upper airway mucosa in CF patients. Methods A flexible OCT probe was used for cross-sectional imaging of the nasal mucosa in 25 CF patients and 25 healthy controls. Results OCT images showed mucosal details including epithelium, basement membrane, lamina propria with seromucinous glands, and underlying cartilaginous structures. Mean nasal mucosa and epithelial layer thickness were increased in CF compared to ...

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