1. All Articles

    1-24 of 15471 1 2 3 4 ... 643 644 645 »
    1. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

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    2. Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Purpose To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber ...

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    3. Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Speckle reduction in optical coherence tomography (OCT) images plays an important role in facilitating further image analysis. Existing despeckling methods generally tend to provide insufficient speckle suppression or limited detail preservation especially at high speckle corruption. To address this problem, this paper proposes a novel iterative nonlocal means (NLM) method to restore OCT images. Different from the classical NLM method, the proposed method computes the weight using an improved weight function in an iterative way and it determines the decay parameter based on the classification of image pixels. The experiments on the clinical OCT images indicate that the proposed method ...

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    4. Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Purpose To compare foveal shapes in Koreans according to age and gender using spectral domain optical coherence tomography (SD-OCT). Methods This study included 230 eyes of 115 healthy adults. The subjects were divided into three groups: group 1 (20-39 years of age), group 2 (40-59 years of age) and group 3 (60-79 years of age). Using spectralis OCT, we measured central foveal thickness (CFT), regional maximal retinal thickness (MRT), pit diameter and pit depth and compared the differences between the groups. Results The MRT of the superior, inferior and nasal sides in group 1 was higher than in groups 2 ...

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    5. Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. The meeting will be organised around 2-3 invited talks, technical sessions with poster sessions interspersed. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. There is no fee for this meeting, however registration is required. Tea, coffee and lunch will be provided for attendants. Please email Mark.Dickinson@manchester.ac.uk or P.H.Tomlins@qmul.ac.uk or N.Krstajic@ed.ac.uk in ...

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    6. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

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    7. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

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    8. Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young, and elderly subjects. Methods: Doppler FD-OCT blood flow was measured using the RTVue system (Optovue Inc., USA). One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ± 5.1 years) subjects was randomly selected and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e. each separate measurement comprising an upper, and ...

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    9. Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Purpose:To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure (PMAC) eyes, mature cataract eyes and their fellow eyes, and identify those parameters that could be used to differentiate PMAC eyes from those with mature cataract and no PMAC. Methods:In this cross-sectional study a total of 33 PMAC subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth(ACD), anterior chamber area(ACA), iris thickness, iris curvature, lens vault(LV), and angle parameters including angle opening distance(AOD750) and trabecular ...

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    10. MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, debuted its NITID TM skin imaging system at the 23 rd Annual European Academy of Dermatology and Venereology Congress in Amsterdam. NITID is a handheld diagnostic device designed to help dermatologists quickly and minimally invasively diagnose skin cancer. Once approved by regulatory bodies, it will be the first point-of-care OCT imaging device that can produce dynamic, real-time, high-resolution diagnostic images with tissue penetration capability of up to two millimeters. “NITID is the result of a decade of research in optical miniaturization technology, and we are thrilled to ...

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    11. Depth extension and sidelobe suppression in optical coherence tomography using pupil filters

      Depth extension and sidelobe suppression in optical coherence tomography using pupil filters

      We demonstrate a new focus engineering scheme to achieve both extended depth of focus (DOF) and sidelobe suppression in spectral-domain optical coherence tomography (SD-OCT) system. Each of the illumination pupil function and the detection pupil function is modulated using an annular pupil filter implemented by center obscuration. The two pupil filters are arranged in a dark-field configuration such that the first sidelobe of the illumination point-spread function (PSF) matches the first minimum of the detection PSF in the lateral focal plane. We tested the feasibility of the proposed scheme numerically, and then constructed a dark-field OCT (DF-OCT) system to further ...

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    12. COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM: Findings on Enhanced Depth Imaging Optical Coherence Tomography in Eight Eyes

      COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM: Findings on Enhanced Depth Imaging Optical Coherence Tomography in Eight Eyes

      Purpose: To assess combined hamartoma of the retina and retinal pigment epithelium with enhanced depth imaging optical coherence tomography. Methods: Retrospective, observational cases series in eight eyes of eight patients, with comparison between affected and unaffected eyes regarding enhanced depth imaging optical coherence tomography features of tumor, fovea, and choroid. Results: The mean age at presentation was 7 years. The tumor was macular (n = 5) or extramacular (n = 3). Enhanced depth imaging optical coherence tomography revealed irregularities in inner retina (n = 8) and/or all retinal layers (n = 3), with epiretinal membrane (n = 8), causing an inner retinal sawtooth (mini-peak ...

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    13. TEMATYS is pleased to announce the release of its new market and technology report "Optical Coherence Tomography for Healthcare and Life Science: Technology and Market Trends"

      TEMATYS is pleased to announce the release of its new market and technology report "Optical Coherence Tomography for Healthcare and Life Science: Technology and Market Trends"

      Optical Coherence Tomography (OCT) is a mature technology well-established on the ophthalmology market. Currently, the ophthalmology OCT market has been slowing down for the last years. However, despite the saturation of the OCT ophthalmology market in developed countries, the OCT market for healthcare and life science is still expected to grow from around € 500M in 2013 to around € 1b in 2019. Strong demand from new biomedical applications, continuous development of innovative technologies, strong demand from developing countries will drive the OCT market growth. The present report provides market forecasts from 2014 to 2019 for the healthcare applications of OCT as ...

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    14. Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Purpose To provide normal macular thickness measurements using Spectral Domain Optical Coherence Tomography (SDOCT, Copernicus, Optopol Technologies, Zawierci, Poland). Methods Fifty eight eyes of 58 healthy subjects were included in this prospective study. All subjects had comprehensive ophthalmic examination including best-corrected visual acuity (BCVA). All the subjects underwent Copernicus SDOCT. Central foveal thickness (CFT) and photoreceptor layer (PRL) thickness were measured and expressed as mean and standard deviation. Mean retinal thickness for each of the 9 regions defined in the Early Treatment Diabetic Retinopathy Study were reported. The data was compared with published literature in Indians using Stratus and Spectralis ...

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    15. Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography

      Findings of secondary corneal amyloidosis  with ultrahigh-resolution optical coherence  tomography

      Purpose: To describe observations by ultrahigh-resolution optical coherence tomography (OCT) in a secondary corneal amyloidosis (SCA) patient with histological analysis of excised tissue. A unique finding under OCT of her fellow eye is also described. Case: A 39-year-old female had suffered from trichiasis in both of her eyes for more than 30 years. Slit-lamp examination showed a milky-white soft mass on her left cornea and a linear opacity on the fellow cornea at the cilia-attached region. OCT demonstrated the presence of a mass region within a thin epithelial layer and no destruction of Bowman’s layer in her left cornea ...

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    16. Optical Coherence Tomography: OCT (Book Chapter)

      Optical Coherence Tomography: OCT (Book Chapter)

      Optical coherence tomography (OCT) allows to measure geometric features inside translucent objects such as organic materials or organic tissues. The principle is based on interferometry. Time-domain and Fourier-domain methods are applied to make visible differences in the refractive index profile of the measuring object. We present the set-up of OCT sensors and show examples of applications such as 3D-imaging of an eye, B-scans of blood vessels or thickness measurements of multi-layer polymer films.

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    17. Optical coherence tomography investigation of ischemic stroke inside a rodent model

      Optical coherence tomography investigation of ischemic stroke inside a rodent model

      Although already in use in several medical domains, only recently optical coherence tomography (OCT) has been applied in the study of ischemic events. In this paper, we will focus on characterizing ischemic stroke, in a rat model, by OCT. Investigations were carried on a set of 25 rats, on which ischemic stroke was inflicted by a transient occlusion of the middle cerebral artery (tMCAO). Animals were sacrificed 1, 3, 7 and 28 days after occlusion. We tested the OCT’s power of detection and discrimination of stroke area compared to both normal, contralateral hemisphere and non-affected brain tissue, together with ...

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    18. An overview of optical coherence tomography for ovarian tissue imaging and characterization

      An overview of optical coherence tomography for ovarian tissue imaging and characterization

      Ovarian cancer has the lowest survival rate among all the gynecologic cancers because it is predominantly diagnosed at late stages due to the lack of reliable symptoms and efficacious screening techniques. Optical coherence tomography (OCT) is an emerging technique that provides high-resolution images of biological tissue in real time, and demonstrates great potential for imaging of ovarian tissue. In this article, we review OCT studies for visualization and diagnosis of human ovaries as well as quantitative extraction of ovarian tissue optical properties for classifying normal and malignant ovaries. OCT combined with other imaging modalities to further improve ovarian tissue diagnosis ...

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    19. Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography

      Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography

      Purpose : The purpose of this study was to classify and detect intraretinal hemorrhage (IRH) in spectral domain optical coherence tomography (SD-OCT). Methods : Initially the presentation of IRH in BRVO-patients in SD-OCT was described by one reader comparing color-fundus (CF) and SD-OCT using dedicated software. Based on these established characteristics, the presence and the severity of IRH in SD-OCT and CF were assessed by two other masked readers and the inter-device and the inter-observer agreement were evaluated. Further the area of IRH was compared. Results : About 895 single B-scans of 24 eyes were analyzed. About 61% of SD-OCT scans and 46 ...

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    20. Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies

      Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies

      In an optical coherence tomography (OCT) scan from a living tissue, red blood cells (RBCs) are the major source of backscattering signal from moving particles within microcirculatory system. Measuring the concentration and velocity of RBC particles allows assessment of RBC flux and flow, respectively, to assess tissue perfusion and oxygen/nutrition exchange rates within micro-structures. In this paper, we propose utilizing spectral estimation techniques to simultaneously quantify bi-directional particle flow and relative flux by spectral estimation of the received OCT signal from moving particles within capillary tubes embedded in tissue mimicking phantoms. The proposed method can be directly utilized for ...

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    21. Very late neoatherosclerotic plaque rupture in drug-eluting stent restenosis

      Very late neoatherosclerotic plaque rupture in drug-eluting stent restenosis

      A 71-year-old man presented in emergency department for non-ST-elevation myocardial infarction. At admission, 12-lead ECG was in sinus rhythm without sign of myocardial ischemia, and troponin slightly increased. The only notable feature of the patient's medical history was single-vessel coronary artery disease revealed 10 years previously, treated by stenting of the second segment of the right coronary artery with a 3.0 x 25 mm bare metal stent. Three months later, intrastent restenosis was managed by implantation of a 3.0 x 28 mm paclitaxel-eluting stent. Two years before the present admission, following a non contributive stress test for ...

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    22. Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: a spectral-domain optical coherence tomographic study

      Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: a spectral-domain optical coherence tomographic study

      Purpose This study was performed to investigate the interocular symmetry of peripapillary retinal nerve fibre layer (RNFL) thickness, as measured by Cirrus high-definition spectral-domain optical coherence tomography (OCT), in healthy eyes. A wide range of subject ages and refractive errors was examined. Methods The retinal nerve fibre layer thickness was measured in 1,234 healthy eyes from 617 subjects using OCT. Interocular differences (right eye minus left eye) in global area and quadrant nerve fibre layer thicknesses were measured. The effect of age and refractive error on interocular nerve fibre layer thickness difference was also examined. Results Means (and standard ...

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    23. Rapid, Accurate, and Non-Invasive Measurement of Zebrafish Axial Length and Other Eye Dimensions Using SD-OCT Allows Longitudinal Analysis of Myopia and Emmetropization

      Rapid, Accurate, and Non-Invasive Measurement of Zebrafish Axial Length and Other Eye Dimensions Using SD-OCT Allows Longitudinal Analysis of Myopia and Emmetropization

      Refractive errors in vision can be caused by aberrant axial length of the eye, irregular corneal shape, or lens abnormalities. Causes of eye length overgrowth include multiple genetic loci, and visual parameters. We evaluate zebrafish as a potential animal model for studies of the genetic, cellular, and signaling basis of emmetropization and myopia. Axial length and other eye dimensions of zebrafish were measured using spectral domain-optical coherence tomography (SD-OCT). We used ocular lens and body metrics to normalize and compare eye size and relative refractive error (difference between observed retinal radial length and controls) in wild-type and lrp2 zebrafish. Zebrafish ...

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    1-24 of 15471 1 2 3 4 ... 643 644 645 »
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