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    1. Supercontinuum generation in silicon nanowire embedded photonic crystal fibers with different core geometries

      Supercontinuum generation in silicon nanowire embedded photonic crystal fibers with different core geometries

      We design various silicon nanowire embedded photonic crystal fibers (SN-PCFs) with different core geometries, namely, circular, rectangular and elliptical using finite element method. Further, we study the optical properties such as group velocity dispersion (GVD), third order dispersion (TOD) of x and y-polarized modes and effective nonlinearity for a wavelength range from 0.8 to 1.6 μm. The proposed structure exhibits almost flat GVD (0.8 to 1.2 μm wavelength), zero GVD (≈ 1.31 μm) and small TOD (0.00069 ps 3 /m) at 1.1 μm wavelength and high nonlinearity (2916 W -1 m -1 ) at 0 ...

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    2. Optical coherence tomography-based predictors for creatine kinase-myocardial band elevation after elective percutaneous coronary intervention for in-stent restenosis

      Optical coherence tomography-based predictors for creatine kinase-myocardial band elevation after elective percutaneous coronary intervention for in-stent restenosis

      Objectives We evaluated whether morphological characteristics of neointimal tissue of in-stent restenosis (ISR) lesions assessed by optical coherence tomography (OCT) affect periprocedural elevation of creatine kinase-myocardial band (CK-MB). Background The impact of neointimal characteristics of ISR lesions on periprocedural myocardial injury has not been sufficiently investigated. Methods A total of 125 patients with ISR lesions underwent elective percutaneous coronary intervention (PCI) and pre-PCI OCT examination. Measurements of CK-MB were performed upon hospitalization, before PCI, and every 8 hr for 24 hr after PCI. CK-MB elevation was defined as levels above the 99th percentile of the upper reference limit. Neoatherosclerosis was ...

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    3. Second International Symposium on Optical Coherence Tomography for Non-Destructive Testing March 25th, 2015

      Second International Symposium on Optical Coherence Tomography for Non-Destructive Testing March 25th, 2015

      Optical Coherence Tomography (OCT) is a well-qualified tool for contactless, structural imaging of various samples. Already well-established in medical applications, in the last years the usage of OCT has been extended to diverse fields of non-destructive testing as well. In course of this progress, various devices for industrial measurements, process monitoring and research were developed. With our invitation to the second international symposium on Optical Coherence Tomography for Non-Destructive Testing OCT4NDT we like to settle a tradition from the well-founded forum for the OCT community. The symposium is intended to serve as a platform enabling an exchange of information on ...

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      Mentions: RECENDT
    4. Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      In current study, we fully integrated near-infrared fluorescence (NIRF) molecular imaging into intravascular OCT structural imaging. The OCT/NIRF single catheter imaging clearly demonstrated the microstructure of atheromata and simultaneously identified ICG-enhancing macrophage abundant lipid-rich areas of the plaques. Ex vivo NIRF imaging evidently validated in vivo OCT-NIRF imaging. NIRF signals on ex vivo fluorescence reflectance imaging colocalized well with in vivo NIRF imaging. In vitro ICG cell uptake, correlative fluorescence microscopy, and histopathology corroborated the in vivo imaging findings. Herein, our research team have solved the issues critical for application of this OCT/NIRF imaging technology to clinical practice ...

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    5. Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

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    6. High-Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator

      High-Definition Optical Coherence Tomography in the Diagnosis of  Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced  Investigator

      Background: Histopathology is the gold standard in the diagnosis of basal cell carcinoma (BCC) but biopsies are invasive and often not the preferred diagnostic method for patients. In this context, non-invasive diagnostic imaging tools such as high definition optical coherence tomography (HD-OCT) have shown promising results in diagnosing BCC in real time, atraumatically and repeatedly. Objective: To evaluate the sensitivity and specificity of HD-OCT in the diagnosis of BCC by an experienced versus an inexperienced investigator and describe typical features in common differential diagnosis of BCC. Patients and methods: Forty three patients with clinical suspicion for BCC were included. The ...

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    7. Predictive Values of Optical Coherence Tomography (OCT) Parameters in Assessment of Glaucoma progression

      Predictive Values of Optical Coherence Tomography (OCT) Parameters in Assessment of Glaucoma progression

      Goal: the purpose of the current study was to estimate the predictive values of optical coherence tomography parameters in early, developed perimetric and terminal glaucoma. Methods: 180 eyes of 120 consecutive patients were evaluated in this retrospective cross sectional pilot study. Copernicus Spectral –domain optical coherence tomography with resolution of 3 mm obtained throught the optic nerve head were included. All examined eyes were divided to four groups (healthy,early, developed perimetric glaucoma and terminal glaucoma). The values of the thicknes of the retinal nerve fibre layer, the size of the disk, the volume of the cup, the E/D ...

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    8. Analysis of peripapilary retinal nerve fiber layer thickness of healthy Chinese from northwestern Shanghai using Cirrus HD-OCT

      Analysis of peripapilary retinal nerve fiber layer thickness of healthy Chinese from northwestern Shanghai using Cirrus HD-OCT

      AIM: To investigate peripapillary retinal nerve fiber layer (RNFL) thickness of healthy Chinese individuals from northwestern Shanghai using Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA, USA). METHODS: The peripapillary RNFL thickness of 720 eyes from 360 healthy Chinese participants were measured using the Optic Disc Cube 200×200 protocol. Each eye was scanned 3 times. Global and each quadrant’s RNFL thickness around the optic nerve were compared between genders, and interocular differences were analyzed. The correlation between global RNFL thickness and age were also assessed in this study. RESULTS: The mean global, superior, nasal, inferior and temporal RNFL ...

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    9. Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent

      Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent

      Aims: The Tryton bifurcation stent has been developed to improve clinical outcomes after treatment of bifurcation lesions. Limited data are available on the use of the Absorb bioresorbable vascular scaffold (BVS) in bifurcation lesions with side branches >2 mm. We present here the acute procedural results and midterm clinical follow-up of the first-in-man combined use of the Tryton stent and the Absorb scaffold for the treatment of complex bifurcation lesions. Methods and results: Ten patients treated with the Tryton stent in combination with Absorb BVS were included in the current report. Offline two- and three-dimensional optical coherence tomography (OCT) analyses ...

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    10. Optical coherence tomography to guide below-the-knee endovascular interventions

      Optical coherence tomography to guide below-the-knee endovascular interventions

      Peripheral arterial disease remains a common cause of leg amputations causing significant morbidity and mortality. Data regarding below-the-knee endovascular interventions is scarce while long-term patency rates via different endovascular revascularization modalities remain limited. OCT offers excellent three dimension endothelial visualization; however its value to guide peripheral interventions has not been studied. We describe the use of OCT to guide endovascular below-the-knee interventions in order to achieve excellent OCT results.

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    11. OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI IN EARLY STAGES OF DIABETIC RETINOPATHY

      OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI IN EARLY STAGES OF DIABETIC RETINOPATHY

      Purpose: To analyze the presence of hyperreflective foci in Type 1 and Type 2 diabetic patients, separately, without clinically significant diabetic macular edema and visual impairment. Methods: Noninvasive, observational prospective study. Seventeen and 19 consecutive Type 1 and Type 2 diabetic patients (33 and 38 eyes), respectively, were recruited. All patients had no clinically significant diabetic macular edema or visual impairment. Two age- and sex-matched control groups were also included. Patients underwent an ophthalmologic examination including spectral domain optical coherence tomography. Hyperreflective foci were counted considering horizontal B-scan passing through the fovea. Results: On spectral domain optical coherence tomography, patients ...

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    12. OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes

      OPTICAL COHERENCE TOMOGRAPHY-GUIDED RANIBIZUMAB INJECTION FOR CYSTOID MACULAR EDEMA IN WELL-CONTROLLED UVEITIS: Twelve-Month Outcomes

      Purpose: To determine whether serial ranibizumab injections are effective in the treatment of cystoid macular edema in patients with chronic controlled noninfectious uveitis. Methods: Five eyes of 5 patients were included in a prospective noncomparative therapeutic trial. They received intravitreal injections of ranibizumab at Day 0 and were followed monthly for 1 year. Injections were repeated monthly if persistent or new cystic edema manifested on optical coherence tomography. The primary outcome measure was the mean change in best-corrected visual acuity from baseline at 12 months. Secondary outcome measures included mean percentage change in central subfield retinal thickness (CST) and incidence ...

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    13. Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis

      Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis

      Background Macular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in healthy individuals using spectral domain optical coherence tomography (SD-OCT). Methods Case-control study of 21 patients with AU and 23 patients with IMU and 34 age-matched healthy controls was performed with Spectralis SD-OCT (Heidelberg Engineering, Germany). High resolution SD-OCT scans and macular mapping were applied for automated measurement of retinal thickness. Standardized, masked manual measurement of the choroidal thickness was performed in the center ...

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    14. Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu wants to figure out how to peer into your soul . . . or at least your brain. An expert in designing computer image processing algorithms, Farsiu is an assistant professor of ophthalmology at Duke Medicine who recently accepted a primary appointment in the Pratt biomedical engineering department with the hopes of strengthening collaborations across the university. “When President Bush said he looked Vladimir Putin in the eye and got a sense of his soul, he was actually on to something,” said Farsiu, who has a long history of collaborating with peers in Duke’s engineering school. “The retina is part ...

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    15. OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

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    16. Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      Software Postdoctoral Position in Optical imaging at Casey Eye Institute, Oregon Health & Science University

      The Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University, is seeking outstanding candidates for the following position in optical imaging research in the field of ophthalmology. Post-Doc (software): optical signal processing, image processing Requirements: PhD degree in a relevant discipline (Biomedical Engineering, Medical Physics, computer science, applied mathematics) is required. Solid background in optical signal processing, (medical) image analysis, segmentation and/or image registration are essential. Experiences in imaging (scanning laser ophthalmoscopy, angiography, microscopy, oximetry, adaptive optics), and software development (GPU programming) are also desirable. The successful candidate will be supervised by ...

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    17. Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch

      Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch

      Most studies evaluating the potential of optical coherence tomography (OCT) for the diagnosis of oral cancer are based on visual assessment of OCT B-scans by trained experts. Human interpretation of the large pool of data acquired by modern high-speed OCT systems, however, can be cumbersome and extremely time consuming. Development of image analysis methods for automated and quantitative OCT image analysis could therefore facilitate the evaluation of such a large volume of data. We report automated algorithms for quantifying structural features that are associated with the malignant transformation of the oral epithelium based on image processing of OCT data. The ...

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    18. Corneal Topographic Analysis of Patients With Mooren Ulcer Using 3-Dimensional Anterior Segment Optical Coherence Tomography

      Corneal Topographic Analysis of Patients With Mooren Ulcer Using 3-Dimensional Anterior Segment Optical Coherence Tomography

      Purpose: To investigate the corneal topography and visual function of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography (3-D AS-OCT). Methods: Fourteen eyes of 9 patients with Mooren ulcer were studied. Pachymetric and axial power maps were obtained by 3-D AS-OCT. The axial power maps were classified into 3 patterns by visual inspection. The distribution of the corneal dioptric power was analyzed by Fourier harmonic expansion. The magnitudes of the spherical component, asymmetry, regular astigmatism, higher-order irregularity, and radial distance from the corneal vertex to the thinnest point of the lesion were determined. Results: The axial power ...

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    19. A survey of current and anticipated use of standard and specialist equipment by UK optometrists

      A survey of current and anticipated use of standard and specialist equipment by UK optometrists

      Purpose To investigate current and anticipated use of equipment and information technology (IT) in community optometric practice in the UK, and to elicit optometrists' views on adoption of specialist equipment and IT. Methods An anonymous online questionnaire was developed, covering use of standard and specialist diagnostic equipment, and IT. The survey was distributed to a random sample of 1300 UK College of Optometrists members. Results Four hundred and thirty-two responses were received (response rate = 35%). Enhanced (locally commissioned) or additional/separately contracted services were provided by 73% of respondents. Services included glaucoma repeat measures (30% of respondents), glaucoma referral refinement ...

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    20. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold;in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular ...

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    21. This is Your Brain's Blood Vessels on Cocaine

      This is Your Brain's Blood Vessels on Cocaine

      New imaging technique shows how cocaine shuts down blood flow in mouse brains A new method for measuring and imaging how quickly blood flows in the brain could help doctors and researchers better understand how drug abuse affects the brain, which may aid in improving brain-cancer surgery and tissue engineering, and lead to better treatment options for recovering drug addicts. The new method, developed by a team of researchers from Stony Brook University in New York, USA and the U.S. National Institutes of Health, was published today in The Optical Society’s ( OSA ) open-access journal Biomedical Optics Express . The ...

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    22. Blood flow dynamics reflect degree of outflow tract banding in Hamburger-Hamilton stage 18 chicken embryos

      Blood flow dynamics reflect degree of outflow tract banding in Hamburger-Hamilton stage 18 chicken embryos

      Altered blood flow during embryonic development has been shown to cause cardiac defects; however, the mechanisms by which the resulting haemodynamic forces trigger heart malformation are unclear. This study used heart outflow tract banding to alter normal haemodynamics in a chick embryo model at HH18 and characterized the immediate blood flow response versus the degree of band tightness. Optical coherence tomography was used to acquire two-dimensional longitudinal structure and Doppler velocity images from control ( n = 16) and banded ( n = 25, 6–64% measured band tightness) embryos, from which structural and velocity data were extracted to estimate haemodynamic measures. Peak blood ...

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    23. Evaluation of two quantitative analysis methods of optical coherence tomography for detection of enamel demineralization and comparison with microhardness

      Evaluation of two quantitative analysis methods of optical coherence tomography for detection of enamel demineralization and comparison with microhardness

      Background and Objective We aimed to evaluate in the same study two quantitative methods for quantification of incipient caries in human dental enamel by using optical coherence tomography (OCT): the optical attenuation coefficient and the area under the A-scan signal, and to compare their results with those obtained from microhardness analysis. Study Design/Materials and Methods One hundred and sixty samples were obtained from 40 sound human third molars, which had their crowns sectioned. Simulated caries were created by a pH cycling method. OCT measurements were performed on the samples, before and after the induced demineralization. We determined the total ...

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