1. All Articles

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    1. Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for the corneal thicknesses of the entire cornea in different stages of keratoconus.

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    2. Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) are cross-sectional, noncontact, highresolution diagnostic modalities for posterior and anterior segment (AS) imaging.The AS-OCT provides tomographic imaging of the cornea, iris, lens, and anterior chamber (AC) angle in several ophthalmic diseases. In glaucoma, AS-OCT is utilized to evaluate the morphology of AS structures involved in the pathogenesis of the disease, to obtain morphometric measures of the AC, to evaluate the suitability for laser or surgical approaches, and to assess modifications after treatment. In patients undergoing surgery, AS-OCT is crucial in the evaluation of the filtering bleb functionality, permitting ...

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    3. OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      Purpose: To demonstrate the ability to monitor geographic atrophy (GA) volumetrically through all retinal layers with high-resolution optical coherence tomography difference maps and average macular volume. Methods: Observational case report. Results: Two patients diagnosed with GA were followed up for multiple years with consecutive high-resolution optical coherence tomography studies along with fundus photography and fluorescein angiography or fundus autofluorescence. Difference maps visually reflect macular thinning associated with expansion of GA witnessed on alternative studies. In addition, these maps show progressive macular thinning within previously delineated areas of GA. Average macular volume quantitatively demonstrates the decreasing volume associated with the expanding ...

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    4. Optical Coherence Tomography in Coronary Artery Disease: Toward Sub cellular Imaging

      Optical Coherence Tomography in Coronary Artery  Disease: Toward Sub cellular Imaging

      Intracoronary optical coherence tomography (OCT) is an interferometric imaging technology that uses near-infrared light to provide cross-sectional images with an axial resolution of 10 μm and a transverse of 20-40 μm in vivo. The imaging capabilities of OCT have enabled visualization of important features of coronary plaque, including thrombus, macrophage, neovascularization, stent implantation and stent strut coverage, which have provided new insights for better understanding of this disease. Frequency domain (FD)-OCT is secondgeneration form of OCT that is able to acquire OCT images at a much higher frame. The high-speed imaging capabilities of FD-OCT have made intravascular OCT practical ...

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    5. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    6. Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include ...

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    7. Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Importance Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. Objective To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert retinal thickness measurements from SD-OCT to equivalent values on TD-OCT. Design, Setting, and Participants A cross-sectional observational study was conducted in private and institutional practices. Persons with diabetes mellitus who had at least 1 eye with central-involved diabetic macular ...

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    8. Highly calcific in-stent restenosis as a substrate for sirolimus-eluting stent very late stent thrombosis

      Highly calcific in-stent restenosis as a substrate for sirolimus-eluting stent very late stent thrombosis

      We describe a case of very late stent thrombosis with documentation of highly calcific restenosis at optical coherence tomography without clear signs of stent malapposition, neoatherosclerosis disruption, or vascular toxicity to stent polymer. To the best of our knowledge, this is one of the first reports dealing with highly calcific restenosis as a potential background to very late stent thrombosis.

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    9. A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      Purpose: To display drusen and geographic atrophy (GA) in a single projection image from three-dimensional spectral domain optical coherence tomography images based on a novel false color fusion strategy. Methods: We present a false color fusion strategy to combine drusen and GA projection images. The drusen projection image is generated with a restricted summed-voxel projection (axial sum of the reflectivity values in a spectral domain optical coherence tomography cube, limited to the region where drusen is present). The GA projection image is generated by incorporating two GA characteristics: bright choroid and thin retina pigment epithelium. The false color fusion method ...

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    10. DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      Purpose: To evaluate changes in the distribution and morphology of intraretinal microexudates and hard exudates (HEs) during intravitreal anti-vascular endothelial growth factor therapy in patients with persistent diabetic macular edema. Methods: Twenty-four patients with persistent diabetic macular edema after photocoagulation were investigated in this prospective cohort study. Each eye was assigned to a loading dose of three anti-vascular endothelial growth factor treatments at monthly intervals. Additional single treatments were performed if diabetic macular edema persisted or recurred. Intraretinal exudates were analyzed over 6 months using spectral domain optical coherence tomography (SD-OCT) and fundus photography. Results: Before treatment, microexudates were detected ...

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    11. Viewing Dentistry in a New Light

      Viewing Dentistry in a New Light

      Dental X-rays expose patients to radiation, require time to process, and can only “see” a limited amount inside the mouth. Now new optical techniques developed by UC San Francisco’s Daniel Fried , PhD, use light to take instantaneous digital images that can provide a better picture of our teeth and could one day zap cavities with pinpoint precision. Daniel Fried, PhD, speaks with Leon Chung, a dental research fellow in his lab. Photo by Susan Merrell Fried, a professor in the School of Dentistry’s Division of Biomaterials and Bioengineering in the Department of Preventive and Restorative Dental Sciences, is ...

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    12. Versatile Swept Source With Adjustable Coherence Length

      Versatile Swept Source With Adjustable Coherence Length

      An electronically controlled optical swept source at 1550 nm using mode locking in a dispersive ring cavity is described. Active mode-locking was achieved by directly modulating the current of a semiconductor optical amplifier (SOA) used as a gain medium. In the static regime, parameters such as linewidth, tuning bandwidth, and contrast were measured, whereas the axial range was determined dynamically. Two types of fiber, dispersion compensation and single mode, are employed in the laser ring cavity. It is demonstrated that the relative lengths of the two types of fiber have little effect on the linewidth, whereas more control on the ...

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    13. New imaging techniques for nonmuscle invasive bladder cancer

      New imaging techniques for nonmuscle invasive bladder cancer

      Purpose of review: Recent advances in imaging techniques provide innovative tools for the detection of bladder cancer. In patients with nonmuscle invasive cancer, there is a need for enhanced visualization of flat growing lesions and multifocal tumors. The aim of new imaging modalities is the improved detection and staging of bladder lesions, as an adjunct to conventional white light endoscopy. Recent findings: Fluorescence cystoscopy with 5-aminolevulinic acid and hexaminolevulinate has been shown to improve the detection of papillary and flat bladder lesions in comparison to conventional white light cystoscopy. Prospective phase III clinical trials have demonstrated advanced diagnostic ability, enhanced ...

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    14. Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Background While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. Objective Evaluation of the potential of High-Definition Optical Coherence Tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and de-cellularisation. Methods Human skin samples were incubated with four different agents: Dispase II, NaCl 1M, Sodium Dodecyl Sulfate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-Definition Optical Coherence Tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by Reflectance Confocal Microscopy (RCM). (Immuno)histopathology ...

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    15. Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for methods to study the interaction between macrophages and crystalline cholesterol. In this study, we demonstrate the feasibility of detecting cholesterol in macrophages in situ using Micro-Optical Coherence Tomography (µOCT), an imaging modality we have recently developed with 1-µm resolution. Macrophages containing cholesterol crystals frequently demonstrated highly scattering constituents in ...

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    16. Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Flight Engineer Alexander Gerst uses the Optical Coherence Tomography camera during an Ocular Health vision test in the Harmony node of the International Space Station. Commander Steve Swanson (left) assists Gerst. Image credit: 
      NASA. Larger image (1 MB): http://www.nasa.gov/sites/default/files/oh_vision_test.jpg

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    17. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    18. Long-Term Outcomes of Neointimal Hyperplasia Without Neoatherosclerosis After Drug-Eluting Stent Implantation

      Long-Term Outcomes of Neointimal Hyperplasia Without Neoatherosclerosis After Drug-Eluting Stent Implantation

      Objectives The aim of this study was to investigate the correlation between in-stent neointimal tissue without features of neoatherosclerosis and long-term clinical outcomes. Background Recent studies have reported differential morphological characteristics of in-stent neointimal tissue assessed by optical coherence tomography (OCT). Methods The study population consisted of 336 patients with 368 drug-eluting stent-treated lesions. Patients received a follow-up OCT examination without any intervention. OCT-based neointima was categorized as homogeneous (n = 227 lesions in 208 patients), heterogeneous (n = 79 lesions in 73 patients), or layered (n = 62 lesions in 55 patients). Major adverse cardiac events (MACE) (a composite of cardiac death ...

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    19. Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose:To compare Subfoveal Choroidal Thickness (SFCT) before and after unenventful cataract surgery using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT). Methods:A prospective study was conducted on 115 eyes of 95 patients who had phacoemulsification. Measurements of SFCT were performed preoperatively and one day (D1), seven days (D7), one month (M1) and three months (M3) after surgery using the EDI OCT technique. Central Retinal Thickness (CRT) was measured before surgery and at M1 and M3. Results:The 95 patients had a mean age of 76±8.3 years. The mean SFCT at baseline was 224±75μm. It ...

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    20. Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Purpose: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT). Methods: 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis software of the OCT system. Limbal ET (LET) in four quadrants was manually measured from OCT images. Results: CET of central 2-mm diameter zone in groups A ...

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    21. Neural Network Analysis of Different Segmentation Strategies of Nerve Fiber Layer Assessment for Glaucoma Diagnosis

      Neural Network Analysis of Different Segmentation Strategies of Nerve Fiber Layer Assessment for Glaucoma Diagnosis

      Purpose: To compare the diagnostic performance of different segmentations of the nerve fiber layer (NFL) thickness measurements using an artificial neural network and to define the optimal number of sectors with best diagnostic ability for glaucoma diagnosis. Methods: A total of 117 glaucoma patients and 123 normal subjects were included in the study. NFL thickness measurements were performed using the Spectralis-OCT (Heidelberg Engineering) to obtain the NFL thickness average; measurements from 2 semicircles, 4 quadrants, and 6, 8, 12, 16, 24, 32, and 64 sectors; and 768 uniformly divided locations around the peripapillary NFL. An artificial neural network evaluation was ...

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    22. Association Between Transient Interface Fluid on Intraoperative OCT and Textural Interface Opacity After DSAEK Surgery in the PIONEER Study

      Association Between Transient Interface Fluid on Intraoperative OCT and Textural Interface Opacity After DSAEK Surgery in the PIONEER Study

      Purpose: The aim of this study was to examine the association between transient interface fluid (TIF) and textural interface opacity (TIO) after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery using intraoperative optical coherence tomography (iOCT) in the PIONEER (Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy) study. Methods: All consecutive eyes that underwent DSAEK between October 2011 and September 2013 from the PIONEER intraoperative and perioperative OCT study were included. iOCT images were captured after lenticule apposition with complete air fill and after air-fluid exchange. Postoperative day 1 OCT images were obtained. Outcome variables included the presence of ...

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    23. Insights of Optical Coherence Tomography in Renal Artery Fibromuscular Dysplasia in a Patient with Spontaneous Coronary Artery Dissection

      Insights of Optical Coherence Tomography in Renal Artery  Fibromuscular Dysplasia in a Patient with Spontaneous Coronary  Artery Dissection

      A 60-year-old woman was admitted for an acute coronary syndrome. Coronary angiography showed a spontaneous coronary artery dissection (SCAD) in the left anterior descending coronary artery (A). A typical image of fibromuscular dysplasia (FMD) was also observed in the right renal artery (B). Optical coherence tomography (OCT) (C) revealed alternating areas of thickening and thinning of the medial layer, corresponding to the typical image of "string of beads" readily identified in the longitudinal reconstruction of the OCT and also in angiography. A very high prevalence of FMD in non-coronary arteries has been recently reported in patients with DCE. Our findings ...

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      Mentions: Fernando Alfonso
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