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    1. IEEE Boston Photonics Society Talk on Swept Source Lasers by Bart Johnson

      IEEE Boston Photonics Society Talk on Swept Source Lasers by Bart Johnson

      The development of swept source lasers has made high-speed optical coherence tomography (OCT) cost effective at 1060 and 1310 nm wavelengths. Axsun Technologies manufactures this type of source and has made inroads into ophthalmology and cardiology applications. The 1060 product, for example, tunes 990-1100 nm at a 100 kHz sweep rate. This external cavity diode laser is tuned by a MEMS Fabry-Perot filter. The act of rapidly sweeping the filter induces a mode-locking behavior. This is because when the pulses deplete the gain medium they are red shifted due to the index rise in the semiconductor optical amplifier associated with ...

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    2. Author Response: Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      Author Response: Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      On behalf of the author team, we thank Hu and Ding 1 for noting our study 2 to be interesting. Hu and Ding raise pertinent questions related to reproducibility of the optical coherence tomography angiography (OCTA) images and intra- and interobserver variability. We do acknowledge that the OCTA examination can take a long time, and patient eye movement can be a confounder in any analyses. There are two issues to be considered. One is the reproducibility of the OCTA image and the other is the reproducibility of the local fractal dimension method. In the latter case, as long as the ...

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    3. Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

      We read with interest the article by Gadde and colleagues 1 on quantifying vessel density and the foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images using a fully automated local fractal dimension method. The authors concluded that this novel method can calculate retinal vessel density and the FAZ area. They also contended that retinal vessel density was not correlated with age and that the inferior zone of retinal vessel density is largest in the parafoveal region. We congratulate and applaud their interesting and important work on this topic; however, we have one question for the authors ...

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      Mentions: Optovue
    4. LONG-TERM RETROSPECTIVE ANALYSIS OF VISUAL ACUITY AND OPTICAL COHERENCE TOPOGRAPHIC CHANGES AFTER SINGLE VERSUS DOUBLE PEELING DURING VITRECTOMY FOR MACULAR EPIRETINAL MEMBRANES

      LONG-TERM RETROSPECTIVE ANALYSIS OF VISUAL ACUITY AND OPTICAL COHERENCE TOPOGRAPHIC CHANGES AFTER SINGLE VERSUS DOUBLE PEELING DURING VITRECTOMY FOR MACULAR EPIRETINAL MEMBRANES

      Purpose: To determine the long-term effect of internal limiting membrane with associated epiretinal membrane (ERM) peeling versus single peeling alone in terms of best-corrected visual acuity and anatomical outcomes on spectral-domain optical coherence tomography. Methods: This retrospective comparative cohort study of patients who had follow-up of >1 year and underwent surgery for ERM by a single surgeon (S.C.) from January 1, 2008 to December 31, 2012 compared cases in which the internal limiting membrane was stained with brilliant blue G to facilitate double peeling (n = 42) and single peeling (n = 43) of the ERM alone for up to 3 ...

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    5. Calibration Phantoms for Optical Coherence Tomography at Aston University

      Calibration Phantoms for Optical Coherence Tomography at Aston University

      Calibration Phantoms for Optical Coherence Tomography Applications are invited for a three year Postgraduate studentship, supported by the School of Engineering and Applied Science, to be undertaken within the Aston Institute of Photonic Technologies at Aston University. The successful applicant will join an established experimental group working on the design and fabrication of calibration phantoms for optical coherence tomography using femtosecond laser materials processing. The studentship is offered in collaboration with Arden Photonics . The position is available to start in October 2016 (subject to negotiation) Financial Support This studentship includes a fee bursary to cover the home/EU fees rate ...

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    6. Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      We have demonstrated for the first time, to our knowledge, the use of optical coherence tomography (OCT) as an analytical tool for nondestructively characterizing the individual paint layer thickness of multiple layered automotive paints. A graph-based segmentation method was used for automatic analysis of the thickness distribution for the top layers of solid color paints. The thicknesses measured with OCT were in good agreement with the optical microscope and ultrasonic techniques that are the current standard in the automobile industry. Because of its high axial resolution (5.5 μm), the OCT technique was shown to be able to resolve the ...

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      Mentions: Yalin Zheng
    7. SS-OCT PCIe Card from Keysight Technologies

      SS-OCT PCIe Card from Keysight Technologies

      Keysight Technologies Inc. offers swept source optical coherence tomography (SS-OCT) application options for the U5303A compact, dual-channel ADC card, delivering high dynamic range and a high effective number of bits for enhanced image quality. The new options support up to 1 GS/s on the 12-bit, high-speed data acquisition peripheral component interconnect express (PCIe) card. Image acquisition is featured at a rate of 200 kHz, continuously. The real-time processing solution allows OEMs to develop SS-OCT engines using the development environment provided, which includes a graphical user interface and C++ programming language. The new options also ensure improved spurious-free dynamic range ...

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    8. Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for en face plotting. We demonstrate the efficiency of proposed additional algorithms as for the microcirculation imaging of hamsters cheek in vivo as for the preliminary microcirculation imaging of patients after ...

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    9. Optical coherence tomography angiography in pediatric choroidal neovascularization

      Optical coherence tomography angiography in pediatric choroidal neovascularization

      Purpose : To report two cases of pediatric choroidal neovascularization (CNV) and the associated neovascular and retinal findings identified on Optical Coherence Tomography Angiography (OCTA) imaging. Methods : A 14-year-old boy with handheld laser-induced maculopathy-related CNV and a 13-year-old boy with idiopathic CNV were evaluated with visual acuity testing, slit-lamp exam, fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography, and OCTA. Results : Macular CNV were identified in both pediatric patients using OCTA imaging. The first case demonstrated a classic pediatric type II CNV with a "tree-like" pattern and a single vessel in-growth site, while the second case demonstrated ...

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    10. Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      We present a case of a patient with non-ST-elevation myocardial infarction due to very late stent thrombosis, 2 years after a sirolimus-eluting stent implantation (SES). Optical coherence tomography (OCT) imaging identified vessel wall destruction of the whole stented coronary segment with multiple cavity formations along the entire stent length, severe struts malapposition and thrombi. The patient was treated successfully with the implantation of a bare metal stent (BMS). Follow-up OCT imaging at 12 months revealed improvement of vascular healing with complete re-endothelialization of the distal parts of the new BMS, while the stent body remained partly uncover suggesting vascular toxicity ...

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    11. Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Purpose To assess the sensitivity and specificity for detecting macular disease with a new optical biometry device with swept-source optical coherence tomography (SS-OCT) used before cataract surgery. Setting Hanusch Hospital, Vienna, Austria. Design Consecutive case series. Methods This study included patients with or without macular disease. All patients were scanned using the new biometry device (IOLMaster 700), which allows a 1.0 mm central retinal scan using SS-OCT technology. Also, all eyes were assessed using a dedicated retinal OCT device (RTVue) on the same day. Two experienced examiners and 1 ophthalmology resident graded all scans individually. Sensitivity and specificity for ...

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    12. Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Laboratories agreed to acquire St. Jude Medical Inc. in a cash-and-stock deal valued at $25 billion that would create one of the leading makers of heart-related devices. Under the deal, Abbott agreed to swap $46.75 in cash and 0.8708 shares for each St. Jude share. The offer values each St. Jude share at about $85, representing a 37% premium to the stock’s closing price Wednesday. Shares of Abbott fell 7% to $40.60 in early trading, while St. Jude rose 25% to $77.70. The companies said the deal merges St. Jude’s strong positions in ...

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      Mentions: St. Jude Medical
    13. Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Orbital Metastasis From Breast Cancer without Significant Changes in CT Scan and MRI

      Dear Editor , Orbital metastasis infrequently occurs in breast cancer ( 1 ); however breast cancer is the most common cause of orbital metastasis ( 2 - 5 ), followed by lung, prostate, gastrointestinal tract, and skin (melanoma) cancers ( 6 , 7 ). Definite diagnosis of an orbital lesion includes an orbital biopsy (either FNA or open biopsy). However, in patients with known metastatic cancer, CT scan or MRI of the orbits can frequently show the presence of a mass, which often involves the orbital fat or extraocular muscles ( 4 , 5 ). On the other hand, these techniques may not completely reflect the metastases. Optical coherence tomography (OCT) is ...

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    14. Optical coherence tomography in oral cancer: A transpiring domain

      Optical coherence tomography in oral cancer: A transpiring domain

      Identification of oral cancer at an early curable stage not only aids in controlling the mortality and morbidity rate but also improves the quality of life of the patient. Indeed, regular monitoring of such life-threatening disease has held an imperative role in cancer diagnostics. Various light-based diagnostics are currently available to the clinician for early diagnosis of oral cancer. Optical coherence tomography (OCT) is one such emerging light-based diagnostic modality that provides noninvasive, real-time images at a depth of 1.5–2 mm and can also be compared to corresponding histopathological sections, hence this procedure can also be referred as ...

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    15. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    16. Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography

      Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography

      The mammary gland extracellular matrix (ECM) is comprised of biopolymers, primarily collagen I, that are created and maintained by stromal fibroblasts. ECM remodeling by fibroblasts results in changes in ECM fiber spacing (pores) that have been shown to play a critical role in the aggressiveness of breast cancer. However, minimally invasive methods to measure the spatial distribution of ECM pore areas within tissues and in vitro 3D culture models are currently lacking. We introduce diffusion-sensitive optical coherence tomography (DS-OCT) to image the nanoscale porosity of ECM by sensing weakly constrained diffusion of gold nanorods (GNRs). DS-OCT combines the principles of ...

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    17. Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development

      Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development

      Ophthotech Corporation (NASDAQ: OPHT) announced today the appointment of Carmen A. Puliafito, MD, MBA, as Chief of Strategic Development. As one of the world's leading experts in ophthalmology and health management, Dr. Puliafito's highly distinguished career includes serving most recently as the Dean of the Keck School of Medicine of the University of Southern California, a position that he held from 2007 to 2016. Under his leadership of 4,000 employees and 1,700 faculty members, the Keck School of Medicine has become one of the nation's preeminent research-intensive medical schools. Dr. Puliafito's prolific accomplishments at ...

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    18. Senior Systems Design Engineer Opening at Carl Zeiss Meditec

      Senior Systems Design Engineer Opening at Carl Zeiss Meditec

      JOB SUMMARY: The Senior Systems Design Engineer will architect, design, specify and validate systems and subsystems; develop algorithms; and contribute to overall system architecture and design. Define and document the subsystem level requirements and architecture. Process tradeoff requested features against architectural decisions. Provide technical direction to a cross-functional product development team in sub system design and troubleshooting. Perform analysis and simulation using modeling tools such as MATLAB, LabVIEW. Critically analyze and verify system performance through simulation, test, and measurements. Lead subsystem and system integration. Perform system level performance verification. Guide and review hardware and software specifications and designs Specify and ...

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    19. Preoperative macular spectral-domain optical coherence tomography in patients considering advanced-technology intraocular lenses for cataract surgery

      Preoperative macular spectral-domain optical coherence tomography in patients considering advanced-technology intraocular lenses for cataract surgery

      Purpose To evaluate spectral-domain optical coherence tomography (SD-OCT) as a strategy for identifying occult macular disease preoperatively in patients scheduled for cataract surgery with implantation of an advanced-technology intraocular lens (IOL). Setting Private practice, Danbury, Connecticut, USA. Design Retrospective consecutive case series. Methods Macular SD-OCT scans were performed on all patients scheduled for cataract surgery and Restor multifocal or toric IOL implantation over a 6-month period. All scans were reviewed for abnormalities of the retina, retinal pigment epithelium, or vitreomacular interface. For subgroup analysis, the following health information was collected: age, sex, smoking history, hypertension, heart disease, hyperlipidemia or hypercholesterolemia ...

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    20. SLO Fundus Imaging Is the Most Sensitive Modality of Multimodal Imaging for Macular Microembolisms with Subtle Signs

      SLO Fundus Imaging Is the Most Sensitive Modality of Multimodal Imaging for Macular Microembolisms with Subtle Signs

      Background. Microemboli of fat or other material into the terminal macular retinal circulation can be difficult to diagnose. We report 2 cases that showed subtle signs where SLO fundus imaging was most sensitive to precisely outline the limits of the inner retina infarction. Patients and Methods. Multimodal imaging analysis was performed including fundus photography, fluorescein angiography, indocyanine green angiography, Optical Coherence Tomography and SLO fundus imaging of 2 cases with suspected infarction of the inner retina. Cases. A 30-year-old man reported a grey central spot OD a few days after being squeezed between two cars with a sacrum fracture. Vision ...

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    21. Spectral Domain Optical Coherence Tomography for the Characterization of Kyrieleis Exudates Involving Both the Fovea and Retinal Vessels

      Spectral Domain Optical Coherence Tomography for the Characterization of Kyrieleis Exudates Involving Both the Fovea and Retinal Vessels

      In 1933 and 1950, Kyrieleis first described the presence of segmental white lesions in the walls of retinal arterioles in a case of ocular tuberculosis [ 1 ], [ 2 ]. These lesions are rarely seen and their pathophysiology remains debated although a relationship with infectious and inflammatory conditions has been proposed [ 3 ]. We report a patient who presented these lesions not only around retinal vessels very much alike those described in the original article but also involving the macular area and retinal veins. Since the patient suffered from dense vitreous haze as a result of an ocular toxoplasmosis relapse, this finding was revealed ...

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    22. Speckle Reduction in 3D Optical Coherence Tomography of Retina by A-Scan Reconstruction

      Speckle Reduction in 3D Optical Coherence Tomography of Retina by A-Scan Reconstruction

      Optical coherence tomography (OCT) is a micrometer-scale, cross-sectional imaging modality for biological tissue. It has been widely used for retinal imaging in ophthalmology. Speckle noise is problematic in OCT. A raw OCT image/volume usually has very poor image quality due to speckle noise, which often obscures the retinal structures. Overlapping scan is often used for speckle reduction in a 2D line-scan. However, it leads to an increase of the data acquisition time. Therefore, it is unpractical in 3D scan as it requires a much longer data acquisition time. In this paper, we propose a new method for speckle reduction ...

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    1-24 of 19168 1 2 3 4 ... 797 798 799 »
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