1. All Articles

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    1. In vivo imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography

      In vivo imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography

      We conducted an initial feasibility study using real-time magneto-motive optical Doppler tomography (MM-ODT) with enhanced contrast to investigate the detection of superparamagnetic iron oxide (SPIO) magnetic nanoparticles implanted into in vivo melanoma tissue. The MM-ODT signals were detected owing to the phase shift of the implanted magnetic nanoparticles, which occurred due to the action of an applied magnetic field. An amplifier circuit-based solenoid was utilized for generating high-intensity oscillating magnetic fields. The MM-ODT system was confirmed as an effective in vivo imaging method for detecting melanoma tissue, with the performance comparable to those of conventional optical coherence tomography and optical ...

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    2. Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

      Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

      We report on the development of a unique sideview handheld hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas the LPDM deflects the tissue Raman signal by 90°, leading to coaligned RS/OCT optical samplings on the tissue. Further study shows that the hybrid RS and OCT technique developed ...

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    3. Tunable Emission Wavelength Stacked InAs/GaAs Quantum Dots by Chemical Beam Epitaxy for Optical Coherence Tomography

      Tunable Emission Wavelength Stacked InAs/GaAs Quantum Dots by Chemical Beam Epitaxy for Optical Coherence Tomography

      We report on Chemical Beam Epitaxy (CBE) growth of wavelength tunable InAs/GaAs quantum dots (QD) based superluminescent diode’s active layer suitable for Optical Coherence Tomography (OCT). The In-flush technique has been employed to fabricate QD with controllable heights, from 5 nm down to 2 nm, allowing a tunable emission band over 160 nm. The emission wavelength blueshift has been ensured by reducing both dots’ height and composition. A structure containing four vertically stacked height-engineered QDs have been fabricated, showing a room temperature broad emission band centered at 1.1 µm. The buried QD layers remain insensitive to the ...

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    4. Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema

      Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema

      Background 26 million people were estimated to be affected by diabetes in 2010 across the globe. Diabetic macular edema (DME) is the most important cause of visual impairment due to diabetic retinopathy. Optical Coherence Tomography (OCT) is a non-invasive modality which produces cross-sectional or three-dimensional, high-resolution images of the retinal layers and quantitative assessment of retinal thickness Aim of study was to study the incidence of different patterns of diabetic macular edema on Optical coherence tomography (OCT), to decide treatment & follow-up protocol. Material & Methods 200 eyes of 167 patients attending the M & J Institute of Ophthalmology and having diabetic macular ...

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    5. Highmark Health’s VITAL Program to Evaluate Avinger’s Novel Treatment for Peripheral Artery Disease

      Highmark Health’s VITAL Program to Evaluate Avinger’s Novel Treatment for Peripheral Artery Disease

      Highmark Health, Allegheny Health Network (AHN) andAvinger, Inc. (NASDAQ:AVGR) announced a collaboration today to evaluate Pantheris™, Avinger’s novel image-guided atherectomy device for the treatment of peripheral artery disease (PAD). The partnership is part of Highmark Health’s VITAL (Verification of Innovation by Testing, Analysis and Learning) Innovation Program. Pantheris, which recently received 510(k) clearance from the United States Food & Drug Administration (FDA), represents an important leap forward in atherectomy, a minimally invasive treatment for PAD in which a catheter-based device is used to remove plaque from a blood vessel. Lumivascular technology utilized in the Pantheris system allows ...

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      Mentions: FDA Avinger
    6. Image registration, averaging, and compounding for high speed extended depth optical coherence tomography

      Image registration, averaging, and compounding for high speed extended depth optical coherence tomography

      An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected ...

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    7. Interferometry employing refractive index dispersion broadening of interference signals

      Interferometry employing refractive index dispersion broadening of interference signals

      An interferometry system includes: a light source, defining a coherence length, an interferometer configured to combine measurement and reference beams to form an output beam, where the interferometer includes a dispersion imbalance between measurement and reference paths large enough to produce a coherence envelope for the system having a width more than twice the coherence length; a phase modulation device configured to introduce a variable phase between the measurement and reference beams; a detector; imaging optics to direct the output beam to the detector and produce an image of the measurement surface; and an electronic processor electronically coupled to the ...

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    8. Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging

      Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging

      An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that ...

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    9. 3D laser coding in glass

      3D laser coding in glass

      This inventive method assures the authenticity of drugs or other valuable substances that reside within product containers, such as syringes. The method includes initially measuring the 3D topology of the glass surface while determining the distance to the glass surface. Thereafter, a desired 3D code is written below the glass surface with a pulsed laser system. The written 3D code is readable using optical coherence topography (OCT) or parallel optical coherence tomography (pOCT) to verify the authenticity of the product container. A system uses this method with a plurality of syringes held within a tray, and a writing apparatus that ...

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    10. Surface emitting laser and optical coherence tomography apparatus

      Surface emitting laser and optical coherence tomography apparatus

      In order to provide a wavelength tunable surface emitting laser capable of improving a wavelength tuning efficiency, provided is a surface emitting laser, including: a first reflector; a semiconductor cavity including an active layer; and a second reflector, the first reflector, the semiconductor cavity, and the second reflector being formed in the stated order, a gap portion being formed between the first reflector and a semiconductor layer, a cavity length being tunable, in which the surface emitting laser has a high reflectivity structure formed between the gap portion and the semiconductor cavity, and an expression of "(.lamda./2).times.m ...

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    11. Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Optical coherence tomography (OCT) is widely used in the diagnosis and detection of glaucomatous progression. Many manufacturers make spectral-domain OCT (SD-OCT) devices, the most widely used type of OCT. In contrast to time-domain OCT, with SD-OCT, a greater area of the retina can be measured without interpolation of data. Additionally, the anterior segment can be imaged using the same machine. Most OCT machines have built-in proprietary software that can measure the peripapillary area as well as the macular region. Most units also have the capability of segmentation analysis, providing data regarding substructures of the retina. These data are presented in ...

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      Mentions: Sanjay G. Asrani
    12. Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Purpose To analyze the morphological features of peripapillary staphylomas associated with high myopia by swept-source optical coherence tomography (OCT). Design Validity analysis. Methods Highly myopic patients (refractive error >8.0 diopters or axial length >26.5 mm) with a peripapillary staphyloma who had undergone swept-source OCT were studied. The non-highly myopic fellow eyes in patients with unilateral high myopia were also studied. The presence of a peripapillary staphyloma was determined by stereoscopic ophthalmoscopic examinations. The OCT features of the peripapillary staphylomas and other peripapillary lesions were evaluated. Results Twenty-five eyes of 16 patients were studied. Twenty-two eyes were highly myopic ...

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    13. A new novolimus-eluting bioresorbable scaffold for large coronary arteries: an OCT study of acute mechanical performance

      A new novolimus-eluting bioresorbable scaffold for large coronary arteries: an OCT study of acute mechanical performance

      Aims To evaluate the acute performance of a novolimus-eluting bioresorbable scaffold (BRS) with a nominal diameter of 4.0 mm (DESolve® XL) using optical coherence tomography (OCT) in terms of appropriate scaffold deployment. Methods and results Ten patients (55.6% male, mean age 60.0 y) undergoing OCT-guided scaffold implantation were enrolled consecutively in this retrospective study. Using data from the final pullback, the following indexes were calculated: mean and minimum area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity and symmetry indexes, strut fracture, and edge dissection. The clinical indication for the procedure was acute coronary syndrome in ...

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    14. Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study)

      Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study)

      Background: The OCTOPUS registry prospectively evaluates the procedural and long-term outcomes of saphenous vein graft (SVG) PCI. The current study assessed the morphology of de novo lesions and in-stent restenosis (ISR) in patients undergoing PCI of SVG. Methods and Results: Optical coherence tomography (OCT) of SVG lesions in consecutive patients presenting with stable CAD and ACS was carried out. Thirty-nine patients (32 de novo and 10 ISR lesions) were included in the registry. ISR occurred in 5 BMS and 5 DES. There were no differences in the presence of plaque rupture and thrombus between de novo lesions and ISR. Lipid-rich ...

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    15. Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography

      Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography

      The imaging depth of optical coherence tomography (OCT) in highly scattering biological tissues (such as luminal organs) is limited, particularly for OCT operating at shorter wavelength regions (such as around 800 nm). For the first time, the optical clearing effect of the mixture of liquid paraffin and glycerol on luminal organs was explored with ultrahigh-resolution spectral domain OCT at 800 nm. Ex vivo studies were performed on pig esophagus and bronchus, and guinea pig esophagus with different volume ratios of the mixture. We found that the mixture of 40% liquid paraffin had the best optical clearing effect on esophageal tissues ...

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    16. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES

      Purpose: To demonstrate the clinical utility of optical coherence tomography (OCT) angiography (OCT-A) in inherited retinal dystrophies complicated by choroidal neovascularization (CNV). Methods: Optical coherence tomography angiography and structural OCT were performed using a 70-kHz spectral domain OCT system using the split-spectrum amplitude-decorrelation angiography algorithm. Semiautomated image processing software was used to segment and measure the CNV. Results: Four participants were enrolled to study the following inherited retinal dystrophies complicated by CNV: choroideremia, EFEMP1-related retinopathy, Best vitelliform dystrophy, and adult-onset vitelliform dystrophy. Interpretation of fluorescein angiography was difficult because of abnormal retinal architecture but suggested the presence of CNV. Structural ...

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    17. Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Objective To assess the agreement between intraoperative measurements of the limbus-insertion distance of the extraocular muscles with those measured by spectral domain optical coherence tomography. Methods An analysis was made of a total of 67 muscles of 21 patients with strabismus. The limbus-insertion distance of the horizontal rectus muscles were measured using pre-operative SD-OCT and intra-operatively in 2 ways: 1) direct, after a conjunctival dissection in patients who underwent surgery, or 2) transconjunctival in patients who were treated with botulinum toxin, or in those who were not going to be operated. The intraclass correlation coefficient and Bland-Altman plots were calculated ...

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    18. Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease

      Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease

      The progression of coronary atherosclerosis has been influenced by the presence of chronic kidney disease (CKD). This study investigated the impact of CKD stages on coronary plaque components observed on optical coherence tomography (OCT). We investigated 296 native coronary lesions with stable angina pectoris treated with stent implantation. All lesions were divided into the three groups according to the values of estimated glomerular filtration rate (eGFR, mL min −1 1.73 m −2 ): the non-CKD group (eGFR ≥60, n = 142), CKD group (15 ≤ eGFR < 60, n = 126), and end-stage kidney disease (ESKD) group (eGFR <15 and/or hemodialysis, n = 28 ...

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    19. Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

      Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

      Background . Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods . A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations’ model ...

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    20. In-stent accordion phenomenon

      In-stent accordion phenomenon

      A 60-year-old female underwent successful stenting of the proximal to distal right coronary artery (RCA). Follow-up angiography was performed 16 months after the index procedure. It revealed moderate in-stent restenosis in the mid-RCA (Fig. 1A). Optical coherence tomography (OCT) was performed to evaluate it. After insertion of the guidewire (SION blue, Asahi Intecc, Nagoya, Japan) into the distal RCA, a short-segment stenosis appeared in the proximal RCA where zotarolimus-eluting stents (Resolute integrity, Medtronic, Minneapolis, MN) were implanted (Fig.

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    21. Everolimus-Eluting Bioresorbable Vascular Scaffolds implanted in Coronary Bifurcation Lesions

      Everolimus-Eluting Bioresorbable Vascular Scaffolds implanted in Coronary Bifurcation Lesions

      Background Limited data are available on bioresorbable vascular scaffolds (BVS) performance in bifurcations lesions and on the impact of BVS wider struts on side-branch impairment. Methods Patients with at least one coronary bifurcation lesion involving a side-branch ≥2 mm in diameter and treated with at least one BVS were examined. Procedural and angiographic data were collected and a dedicated methodology for off-line quantitative coronary angiography (QCA) in bifurcation was applied (eleven-segment model), to assess side-branch impairment occurring any time during the procedure. Two- and three-dimensional QCA was used. Optical coherence tomography (OCT) analysis was performed in a subgroup of patients ...

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    22. Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Optical coherence tomography (OCT) was introduced about two decades ago and has revolutionized ophthalmic practice in recent years. It is a noninvasive noncontact imaging modality that provides a high-resolution cross-sectional image of the cornea, retina, choroid and optic nerve head, analogous to that of the histological section. Advances in OCT technology in signal detection technique from time-domain (TD) to spectral-domain (SD) detection have given us the potential to study various retinal layers more precisely and in less time. SD-OCT better delineates structural changes and fine lesions in the individual retinal layers. Thus, we have gained substantial information about the pathologic ...

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    23. Optovue announces new AngioVue Retina imaging option commercial availability

      Optovue announces new AngioVue Retina imaging option commercial availability

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is pleased to announce the immediate availability of Optovue AngioVue Retina, a proprietary imaging option that provides retina specialists with a non-invasive, dyeless way to quickly visualise blood flow in the retina. AngioVue Retina is configured with essential OCT-A and OCT features, designed specifically for retinal practices to allow adoption of OCT and OCT-A into the clinical workflow with minimal disruption. John Hawley, Senior Vice President of global sales for Optovue, said, “By adding AngioVue Retina to our product portfolio, we are able to help retinal ...

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      Mentions: Optovue Haag-Streit
    24. Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Purpose To describe optical coherence tomography angiography (OCTA) findings in multifocal choroiditis (MFC) with active lesions and to characterize the concordance between the OCTA and other traditional imaging modalities. Design Reliability and validity analysis. Methods Patients with suspected choroidal neovascularization (CNV) or acute inflammatory lesions associated with MFC were assessed in this study. All participants underwent preliminary traditional multimodal imaging including color fundus photography, fundus autofluorescence, near-infrared reflectance imaging, spectral-domain optical coherence tomography, and fluorescence angiography (FA). The participants were prospectively recruited to perform OCTA. OCTA findings of active lesions were compared with other traditional imaging results. Vascular flow signal ...

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