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    1. Oregon Health and Science University Receives NIH Grant for Studying In Vivo Organ of Corti Mechanoelectric Physiology

      Oregon Health and Science University Receives  NIH Grant for Studying In Vivo Organ of Corti Mechanoelectric Physiology

      Oregon Health and Science University Receives a 2015 NIH Grant for $370,365 for Studying In Vivo Organ of Corti Mechanoelectric Physiology. The principal investigator is Alfred Nuttall. THe program began in 1979 and ends in 2016. Below is a summary of the proposed work. A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the basilar membrane, a process known as cochlear amplification (CA). Two questions of broad interest are to be studied; how do the outer hair cells transmit force to activate the CA ...

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    2. Johns Hopkins University Receives NIH Grant for a OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery

      Johns Hopkins University Receives NIH Grant for a OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery

      Johns Hopkins University Receives a 2015 NIH Grant for $445,134 for a OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery. The principal investigator is Jin U. Kang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Contemporary retinal microsurgery is performed by skilled surgeons through operating microscopes, utilizing free hand techniques and manually operated precision micro-instruments. We have assembled an interdisciplinary team including a clinician scientist and vitreoretinal surgeon, an optical device scientist and a systems integrator to translate existing and developing technology in our laboratories into practical application. To ...

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    3. Columbia University Receives NIH Grant for Measures of Human Receptor and Post Receptor Activity

      Columbia University Receives NIH Grant  for Measures of Human Receptor and Post Receptor Activity

      Columbia University Receives a 2015 NIH Grant for $581,231 for Measures of Human Receptor and Post Receptor Activity. The principal investigator is Donald Hood. The program began in 1991 and ends in 2016. Below is a summary of the proposed work. Our long-term objective has been to develop a set of noninvasive techniques for studying the human retina. By applying novel techniques and current theories of phototransduction to the full-field electroretinogram (ERG), we have successfully developed widely-used noninvasive techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices ...

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    4. Cleveland Clinic Receives NIH Grant to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives NIH Grant to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery

      Cleveland Clinic Receives a 2015 NIH Grant for $203,124 to Study Intraoperative Optical Coherence Tomography for Ophthalmic Surgery. The principal investigatgor is Justis Ehlers. The program began in 2013 and ends in 2018. Below is a summary of the proposed work. Optical coherence tomography (OCT) has revolutionized the management of ophthalmic diseases with the precise anatomic information it provides with non-invasive imaging. The high-resolution cross-sectional tissue details make OCT a natural complement to ophthalmic surgery. Intraoperative OCT (iOCT) has the potential to provide real-time feedback to surgeons thus improving surgical care and outcomes. This research activity will focus on ...

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    5. Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractal-based features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of < 0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas ...

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    6. Development of Photothermal Optical Coherence Tomography for In Vivo Imaging of Contrast Agents (Thesis)

      Development of Photothermal Optical Coherence Tomography for In Vivo Imaging of Contrast Agents (Thesis)

      Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation and progression, drug delivery, and treatment response. In cancer in particular, high resolution imaging is essential for capturing spatial heterogeneities in molecular expression and the tumor microenvironment that cause significant barriers to treatment efficacy and drug delivery. Optical coherence tomography (OCT) fills the niche of cellular-level resolution and penetration depths in tissue that exceed those obtained with microscopy, an attractive regime for imaging mouse models of cancer. In this dissertation ...

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    7. Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography

      Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography

      Presented here are new processing techniques for optical coherence tomography (OCT) data that allow for improved visualization and use of full-range OCT images. These techniques minimize the central line artifact and the complex conjugate artifact without requiring additional system hardware or significantly increasing post-processing time. The central line artifact is minimized by normalizing each A-scan to account for ripples at the zero-delay position. The complex conjugate artifact is minimized by segmentation of a layer or layers that cross the zero-delay position, and in some embodiments by further segmentation of other surfaces based on the segmentation of the initial layer or ...

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    8. Microscope Integrated Intraoperative Spectral Domain Optical Coherence Tomography for Cataract Surgery: Uses and Applications

      Microscope Integrated Intraoperative Spectral Domain Optical Coherence Tomography for Cataract Surgery: Uses and Applications

      Aim : To demonstrate the uses and applications of a microscope integrated intraoperative Optical Coherence Tomography in Micro Incision Cataract Surgery (MICS) and Femtosecond Laser Assisted Cataract Surgery (FLACS). Methods : Intraoperative real time imaging using the RESCAN™ 700 (Carl Zeiss Meditec, Oberkochen, Germany) was done for patients undergoing MICS as well as FLACS. The OCT videos were reviewed at each step of the procedure and the findings were noted and analyzed. Results : Microscope Integrated Intraoperative Optical Coherence Tomography was found to be beneficial during all the critical steps of cataract surgery. We were able to qualitatively assess wound morphology in clear ...

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    9. Plaque vulnerability at non-culprit lesions in obese patients with coronary artery disease: Frequency-domain optical coherence tomography analysis

      Plaque vulnerability at non-culprit lesions in obese patients with coronary artery disease: Frequency-domain optical coherence tomography analysis

      Background Obesity is associated with adverse atherosclerotic cardiovascular events. While various metabolic abnormalities associated with obesity promote plaque formation, the morphological phenotype of atherosclerotic plaque has not been well characterized in the setting of obesity. Frequency-domain optical coherence tomography (FD-OCT) enables in vivo visualization of plaque microstructures associated with vulnerability. We characterized plaque microstructures in obese patients. Methods FD-OCT imaging was performed in 308 patients with coronary artery disease undergoing percutaneous coronary intervention. Patients were stratified according to the presence or absence of obesity (body mass index > 30 kg/m 2 ). Plaques in obese ( n  = 129) and non-obese ( n  = 179 ...

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    10. Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression - Online First

      Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression - Online First

      Previous reports of ocular abnormalities in Huntington’s disease (HD) have detailed eye movement disorders. The objective of this case–control study was to investigate optic nerve and macular morphology in HD using optical coherence tomography (OCT). A total of 26 HD patients and 29 controls underwent a thorough ophthalmic examination including spectral domain OCT scans of the macula and peripapillary retinal nerve fibre layer (RNFL). Genetic testing results, disease duration, HD disease burden scores and Unified HD Rating Scale motor scores were acquired for HD patients. Temporal RNFL thickness was significantly reduced in the HD group (62.3 vs ...

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    11. Comparison of long-term in-stent vascular response between abluminal groove-filled biodegradable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent: 3-year OCT follow-up from the TARGET I trial

      Comparison of long-term in-stent vascular response between abluminal groove-filled biodegradable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent: 3-year OCT follow-up from the TARGET I trial

      The study sought to compare long-term optical coherence tomography (OCT)-based in-stent vascular response between the abluminal groove-filled biodegradable polymer sirolimus-eluting stent (SES) and the durable polymer everolimus-eluting stent (EES) in the TARGET I trial. The TARGET I trial was a prospective, multicenter, randomized clinical trial which enrolled 458 patients with single de novo lesions treated by abluminal groove-filled biodegradable polymer SES and EES. A subset of 43 patients underwent angiography and OCT examinations at 3 years. All OCT images were analyzed at 0.4 mm intervals. A similar increase in angiographic late lumen loss was observed in SES and ...

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    12. Optical Coherence Tomography Findings and Visual Outcome after Treatment with Intravitreal Bevacizumab in Parafoveal Telangiectasia

      Optical Coherence Tomography Findings and Visual Outcome after Treatment with Intravitreal Bevacizumab in Parafoveal Telangiectasia

      Methods: A prospective interventional study of 40 patients (80 eyes) with bilateral parafoveal telengectiasis. They were divided into three groups. Group 1 which included 15 patients with PFT were under observation and treated conservatively. Group 2 included 14 patients with PFT complicated by cystoid macular oedema who were treated with intravitreal injection of bevacizumab each (0.1 ml) under aseptic conditions. Group 3 included 11 patients with PFT and choroidal neovascular membranes who were treated with intravitreal injections of bevacizumab. In the three groups pre interventional and post interventional visual acuities were recorded. Pre and post intervention macular thickness was ...

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    13. Design and Fabrication of Optical Polymer Waveguide Devices for Optical Interconnects and Integrated Optical Coherence Tomography (Thesis)

      Design and Fabrication of Optical Polymer Waveguide Devices for Optical Interconnects and Integrated Optical Coherence Tomography (Thesis)

      Optical interconnects is a promising technique to boost the speed of electronic systems through replacing high speed electrical data buses using optical ones. Optical coherence tomography is an attractive imaging technique that has been widely used in medical imaging applications with capability of high resolution subsurface cross sectional imaging in living tissues. Both the optical interconnects and the optical coherence tomography imaging may benefit from the use of integrated optics technology in particular polymer waveguides that can be designed and fabricated to improve the device capability, system compactness, and performance reliability. In this dissertation, we first present our innovative design ...

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    14. Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Importance New methods are needed to compare peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements taken from time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT). Objective To compare the agreement of measured and predicted pRNFLT using different equations based on pRNFLT measurements obtained by TD-OCT and SD-OCT. Design, Setting, and Participants Cross-sectional single-center study that took place at the Department of Ophthalmology, University of Erlangen–Nuremberg from November 16, 2005, to June 3, 2015, and included 138 eyes of control participants, 126 eyes of patients with ocular hypertension, 128 eyes of patients with preperimetric glaucoma, and 160 eyes of ...

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    15. Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Purpose: To assess the repeatability and reproducibility of corneal power values obtained by a Fourier-domain optical coherence tomography (FD-OCT) system (RTVue) and to compare them with the values obtained by a Scheimpflug camera system (Pentacam HR) and by automated keratometry (IOL Master). Methods: Thirty-two eyes from 32 healthy subjects were included in this prospective study. Two experienced observers measured each eye 3 consecutive times with the Pentacam, IOLMaster, and RTVue centered on either the pupil or corneal vertex. The conventional keratometry equivalent (CKE) and anterior (Ka), posterior (Kp), and net (Kn) corneal power values were determined. Results: The corneal power ...

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    16. Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Importance Optical coherence tomography (OCT) has transformed the clinical management of a myriad of ophthalmic conditions. Applying OCT to ophthalmic surgery may have implications for surgical decision making and patient outcomes. Objective To assess the feasibility and effect on surgical decision making of a microscope-integrated intraoperative OCT (iOCT) system. Design, Setting, and Participants Report highlighting the 1-year results (March 2014–February 2015) of the RESCAN 700 portion of the DISCOVER (Determination of Feasibility of Intraoperative Spectral Domain Microscope Combined/Integrated OCT Visualization During En Face Retinal and Ophthalmic Surgery) study, a single-site, multisurgeon, prospective consecutive case series regarding this investigational ...

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    17. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI (n=113) or standard PCI (n=75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8-9.4 ...

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    18. Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography

      Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography

      Purpose : We evaluated the incongruous observation whereby flecks in recessive Stargardt disease (STGD1) can exhibit increased short-wavelength autofluorescence (SW-AF) that originates from retinal pigment epithelium (RPE) lipofuscin, while near-infrared AF (NIR-AF), emitted primarily from RPE melanin, is usually reduced or absent at fleck positions. Methods : Flecks in SW- and NIR-AF images and spectral-domain optical coherence tomography (SD-OCT) scans were studied in 19 STGD1 patients carrying disease-causing ABCA4 mutations. Fleck spatial distribution and progression were recorded in serial AF images. Results : Flecks observed in SW-AF images typically colocalized with darkened foci in NIR-AF images; the NIR-AF profiles were larger. The decreased ...

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    19. Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      In recent years, optical coherence tomography (OCT) has developed into one of the most important imaging techniques in ophthalmology. Nonetheless, this technology is still evolving rapidly as recent developments in multimodal swept-source OCT devices and 4-dimensional real-time OCT demonstrate. Another currently developing sector in OCT application is the intraoperative use of OCT technology. Several approaches have been used to transfer OCT into an intraoperative setting, beginning with OCT-compatible positioning of the anesthetized patient 1 and handheld OCT devices. 2

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    20. Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography

      Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography

      Background and Objectives Optical microangiography (OMAG) is a noninvasive technique capable of imaging 3D microvasculature. OMAG-based optical lymphangiography has been developed for 3D visualization of lymphatic vessels without the need for exogenous contrast agents. In this study, we utilize the optical lymphangiography to investigate dynamic changes in lymphatic response within skin tissue to depilation-induced inflammation by using mouse ear as a simple tissue model. Materials and Methods A spectral-domain optical coherence tomography (OCT) system is used in this study to acquire volumetric images of mouse ear. The system operates under the ultrahigh-sensitive OMAG scanning protocol with five repetitions for each ...

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    21. Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Background To explore the changes in thickness in different areas and layers of the macula under different refractive conditions. Methods Consecutive participants were enrolled in the study. Optical coherence tomography (OCT) images were obtained using a spectral-domain system. We studied the relationships of the full, inner and outer retinal thicknesses of the fovea, parafovea and perifovea relative to the spherical equivalent (SE) and axial length (AL). Results We included 107 eyes; the analysis revealed that the men had thicker foveas (man vs women: 236.70 ± 18.97 μm vs 247.25 ± 16.70 μm P  = 0.002) and inner parafoveas ...

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    22. In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      Vascular abnormalities serve as a key indicator for many skin diseases. Currently available methods in dermatology such as histopathology and dermatoscopy analyze underlying vasculature in human skin but are either invasive, time-consuming, and laborious or incapable of providing 3D images. In this work, we applied for the first time dual-modality photoacoustic and optical coherence tomography that provides complementary information about tissue morphology and vasculature of patients with different types of dermatitis. Its noninvasiveness and relatively short imaging time and the wide range of diseases that it can detect prove the merits of the dual-modality imaging system and show the great ...

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    23. OCT helps identify cancerous brain tissue

      OCT helps identify cancerous brain tissue

      A brain cancer diagnosis can represent a death sentence, with remaining life measured in months to a year or so. Neurosurgery can increase the predicted survival time by up to 200%, depending upon the amount of tumour that can be resected. Distinguishing cancerous tissue from healthy brain tissue can be difficult, however, especially when it has infiltrated white matter. Current imaging detection technologies are suboptimal. Optical coherence tomography (OCT) offers the potential to identify cancerous brain tissue during surgery in an efficient and cost-effective manner. OCT can provide high-resolution volumetric imaging to a millimetre depth and deliver continuous, quantitative feedback ...

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    24. Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction

      Purpose: To evaluate optical coherence tomography meibography (OCT-M) in patients with and without obstructive meibomian gland dysfunction (MGD) and to determine the relationship between OCT-M and ocular surface clinical tests. Methods: Twenty-two patients with MGD and 16 control subjects were included. Each patient underwent an evaluation of ocular surface disease symptoms, lid margin abnormality score, lipid layer thickness evaluation, and meibomian gland (MG) morphological changes using noncontact infrared meibography and OCT-M. OCT-M scans were acquired in 4 different locations. OCT-M parameters including the MG length and width and palpebral conjunctival thickness were evaluated. Results: Within the OCT-M parameters, the mean ...

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      Mentions: Ningli Wang
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