1. All Articles

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    1. Relationship between optic nerve head and retinal nerve fiber layer with central corneal thickness in primary open angle glaucoma: A three-dimensional optical coherence tomography study

      Relationship between optic nerve head and retinal nerve fiber layer with central corneal thickness in primary open angle glaucoma: A three-dimensional optical coherence tomography study

      INTRODUCTION: The purpose of the study is to evaluate the relationship between optic nerve head (ONH) parameters, and retinal nerve fiber layer (RNFL) thickness with central corneal thickness (CCT) in primary open angle glaucoma (POAG) patients by using three dimensional spectral domain optical coherence tomography (3D SD-OCT). METHODS: In this cross-sectional study, a total of 144 eyes of 144 patients (79 female, 65 male) with POAG were studied. Patients were classified as thick cornea group (Group 1) and thin cornea group (Group 2). Group 1 represented eyes with CCT≥540μm and Group 2 with CCT< 540μm. Topographic measurements ...

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    2. Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

      Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

      Purpose To assess the change in the macular layers in the fellow eyes of unilateral retinal vein occlusion (RVO) patients and to evaluate whether certain layers are more affected based on RVO type. Methods This retrospective study included 87 fellow eyes of patients with unilateral RVO (26 central, 61 branch) and 105 eyes of 105 subjects without RVO. Spectral domain optical coherence tomography was used for automatized retinal segmentation. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cells, inner plexiform, inner nuclear, outer plexiform, outer nuclear, photoreceptor layers, overall inner retinal layers and retinal pigment epithelium (RPE) were documented ...

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    3. Corneal Curvature Measurements Utilizing a New Swept-source Optical Coherence Tomography Tomey OA-2000® and Comparison With IOL Master® 500 in Pterygium Patients

      Corneal Curvature Measurements Utilizing a New Swept-source Optical Coherence Tomography Tomey OA-2000® and Comparison With IOL Master® 500 in Pterygium Patients

      Introduction: Corneal curvature (CC) is an important anterior segment parameter. This study compared CC measurements conducted with two optical devices in pterygium eyes. Methods: Sixty pterygium eyes of 30 patients were enrolled in this study. CC was measured three times with the optical biometer and topography-keratometer Tomey OA-2000 (Tomey Corporation, Nagoya, Japan), then with partial optical coherence interferometry (PCI) IOL Master 500 (Carl Zeiss Meditec, Dublin, CA) and data were statistically analysed. Results: The measurements revealed in a mean CC of 43.86 ± 1.57 D with Tomey OA-2000 and 43.84 ± 1.55 D with IOL Master. Distribution of ...

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    4. Optical coherence tomography angiography features of paracentral acute middle maculopathy in a young female in sub-Saharan Africa: A case report

      Optical coherence tomography angiography features of paracentral acute middle maculopathy in a young female in sub-Saharan Africa: A case report

      To report the Optical Coherence Tomography Angiography features of a 33-year-old female presenting with visual loss secondary to a paracentral acute middle maculopathy. A case report of clinical examination findings, Fundus fluorescein angiography and Angiovue optical coherence tomography angiography (OCTA) findings of a paracentral acute middle maculopathy. The Angiovue optical coherence tomography angiography (OCTA) software of the RTVue XR Avanti (Optovue, Inc., Fremont, CA) was used for imaging. Enface OCTA images demonstrate a hypereflective plaque extending from the supero temporal area of the optic disc to the perifovealarea. The 3.0 x 3.0 mm enface OCTA retina thickness map ...

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    5. Retinal optical coherence tomography image enhancement via deep learning

      Retinal optical coherence tomography image enhancement via deep learning

      Optical coherence tomography (OCT) images of the retina are a powerful tool for diagnosing and monitoring eye disease. However, they are plagued by speckle noise, which reduces image quality and reliability of assessment. This paper introduces a novel speckle reduction method inspired by the recent successes of deep learning in medical imaging. We present two versions of the network to reflect the needs and preferences of different end-users. Specifically, we train a convolution neural network to denoise cross-sections from OCT volumes of healthy eyes using either (1) mean-squared error, or (2) a generative adversarial network (GAN) with Wasserstein distance and ...

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    6. Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

      Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

      This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.

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    7. Reproducibility of optical coherence tomography in vein grafts used for coronary revascularization

      Reproducibility of optical coherence tomography in vein grafts used for coronary revascularization

      Background: Optical coherence tomography (OCT) is a high-resolution imaging modality able to provide near-histological images of vessel walls making it possible to distinguish intima and media layers of the vessel wall separately. The use of this imaging technique is increasing while data on the variability and reliability is lacking. The aim of this study was to investigate the reproducibility of frequency-domain OCT in vein grafts used for coronary revascularization. Methods: Five pullbacks were analyzed by the same analyst with a 1-month delay (intraobserver) and by two different analysts (interobserver). Five pairs of pullbacks from the same catheters and vein graft ...

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    8. RELATIONSHIP BETWEEN ABNORMALITIES OF PHOTORECEPTOR MICROSTRUCTURES AND MICROVASCULAR STRUCTURES DETERMINED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH BRANCH RETINAL VEIN OCCLUSION

      RELATIONSHIP BETWEEN ABNORMALITIES OF PHOTORECEPTOR MICROSTRUCTURES AND MICROVASCULAR STRUCTURES DETERMINED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH BRANCH RETINAL VEIN OCCLUSION

      Purpose: To determine whether the size of the foveal avascular zone (FAZ) is significantly correlated with the best-corrected visual acuity (BCVA) and to examine the relationship between the size and microstructural changes of the photoreceptors in eyes with a branch retinal vein occlusion . Methods: The medical records of 69 eyes of patients (mean age, 64.6 ± 11.7 years) with a branch retinal vein occlusion were reviewed after the resolution of macular edema. All the patients underwent optical coherence tomography angiography for measurement of the FAZ area and spectral domain optical coherence tomography for determination of microstructural changes of the ...

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    9. Visualization of the pulp chamber roof and residual dentin thickness by spectral-domain optical coherence tomography in vitro

      Visualization of the pulp chamber roof and residual dentin thickness by spectral-domain optical coherence tomography in vitro

      The aim of this study was to evaluate the ability of spectral-domain optical coherence tomography (SD-OCT) to display the roof of the pulp chamber and to estimate the residual dentin thickness (RDT) of the pulp complex. The roots of 20 extracted human molars were embedded in epoxy resin, and crowns were longitudinally sectioned in the mesial-distal direction, exposing the pulp chamber. The coronal part of the crown was removed up to an RDT to the pulp chamber roof of 2 mm. Samples were imaged by SD-OCT from coronal view and by light microscopy (LM) in the sagittal plane. Using a ...

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    10. Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis

      Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis

      Purpose . To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods . A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results . Significant macular thinning was observed in all ETDRS areas ( ) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors ...

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    11. Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade

      Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade

      Purpose Lid-parallel conjunctival folds (LIPCOF) are a well-accepted clinical sign in dry eye diagnosis. Commonly, LIPCOF is classified by grading the number of folds observed by slit-lamp microscope. This study investigated the relationship between subjective grading scale and LIPCOF morphology imaged by optical coherence tomography (OCT). Methods Temporal and nasal LIPCOF of 42 subjects (mean age 27.3 ± 8.4 (SD) years; 13 M, 29 F) were observed and classified by an experienced optometrist using the Pult LIPCOF grading scale (0: no permanent, lid-parallel conjunctival fold; 1: one fold; 2: two folds, 3: three or more folds). Additionally, LIPCOF cross-sectional ...

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    12. The role of optical coherence tomography in the evaluation of compressive optic neuropathies

      The role of optical coherence tomography in the evaluation of compressive optic neuropathies

      Purpose of review Optical coherence tomography (OCT) is a noninvasive imaging tool routinely used in ophthalmology that provides cross-sectional images of the retina. Compression of the anterior visual pathways results in progressive thinning of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) and this review will highlight the utility of OCT in evaluating patients with this condition. Recent findings The RNFL and macular GCC have been found to highly correlate with visual function in patients with compressive optic neuropathies. Preoperative RNFL and macular GCC thickness have emerged as the most reliable and consistent prognostic factors for ...

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    13. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CHANGES AFTER SUBTHRESHOLD MICROPULSE YELLOW LASER IN DIABETIC MACULAR EDEMA

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CHANGES AFTER SUBTHRESHOLD MICROPULSE YELLOW LASER IN DIABETIC MACULAR EDEMA

      Purpose: To assess changes on optical coherence tomography ( OCT ) angiography in diabetic macular edema (DME) treated with subthreshold micropulse yellow laser (SMPL) over a period of 6 months. Methods: Thirty-five eyes (35 consecutive patients) with treatment-naive DME prospectively underwent (at baseline, 3 and 6 months) best-corrected visual acuity, swept-source OCT angiography / OCT , and fundus autofluorescence . Following parameters were evaluated on OCT angiography in the superficial capillary plexus (SCP) and deep capillary plexus (DCP): the area of foveal avascular zone, number of microaneurysms (MA), area of cysts, and presence of capillary network alterations. Microaneurysm change was also evaluated in 15 fellow ...

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    14. Difference In Treatment Outcomes According To Optical Coherence Tomography–based Stages In Type 3 Neovascularization (RETINAL Angiomatous Proliferation)

      Difference In Treatment Outcomes According To Optical Coherence Tomography–based Stages In Type 3 Neovascularization (RETINAL Angiomatous Proliferation)

      Purpose: To compare 12-month treatment outcomes of Type 3 neovascularization among its different stages as classified using an optical coherence tomography –based method. Methods: This retrospective observational study included 40 patients (40 eyes) who were newly diagnosed with Type 3 neovascularization . The patients were initially administered 3 monthly anti–vascular endothelial growth factor injections. Repeat treatment was performed when recurrence of fluid was noted. Disease staging was classified using the optical coherence tomography –based method. The best-corrected visual acuity at diagnosis and at 12 months and degree of change in best-corrected visual acuity were compared among the different stages of ...

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    15. Avinger Announces Successful Treatment of First Patients Globally with Pantheris SV, a New Image-Guided Atherectomy Device Designed to Treat Smaller Vessels

      Avinger Announces Successful Treatment of First Patients Globally with Pantheris SV, a New Image-Guided Atherectomy Device Designed to Treat Smaller Vessels

      Avinger, Inc. (NASDAQ: AVGR), a commercial-stage medical device company that designs and develops the first-ever image-guided, catheter-based system that diagnoses and treats patients with peripheral artery disease (PAD), today announced the successful treatment of the first nine patients with Pantheris SV (Small Vessel) at two separate hospitals in Germany. Dr. Arne Schwindt, a vascular surgeon at St. Franziskus Hospital Muenster and longtime innovator with Lumivascular technology, performed the first procedures globally. Additional cases were performed by Dr. Ulrich Sunderdiek, an interventional radiologist and cardiac surgeon at Marienhospital Osnabrueck. Pantheris SV was used to successfully treat a variety of lesion types ...

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    16. An Overview of OCT Techniques for Detection of Ophthalmic Syndromes

      An Overview of OCT Techniques for Detection of Ophthalmic Syndromes

      The retina is an essential part of the human eye. It is a very small part at the subsequent pole of the human eye, and it is composed of a tissue cell that can detect the presence of light. The tissue is sensitive enough to detect the amount of light present, its intensity, and a range of different wavelengths as well. These tissues generate nerve signals, and those signals are passed to the brain via the optic nerve. If the retina malfunctions, then different retinal disorders can occur such as diabetic retinopathy, glaucoma, and pathologic myopia. These can be considered ...

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    17. En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      Objective To investigate the application of en face optical coherence tomography (OCT) imaging in eyes with hydroxychloroquine (HCQ) retinopathy. Design Retrospective case series Methods: Setting Institutional Patient Population Sixty-two eyes of 31 Asian patients with HCQ retinopathy. Observation Procedures Macular volume scanning using swept-source OCT was performed in 6 × 6 and 9 × 9 mm areas centered on the fovea. Segmentation of the photoreceptor layers was automatically performed between the inner border of the ellipsoid zone and that of the retinal pigment epithelium-Bruch’s membrane complex to obtain en face OCT images. Findings from the en face images were qualitatively and ...

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    18. A vision exam focused on preemies

      A vision exam focused on preemies

      Many babies born prematurely grow up to be healthy, happy kids. But those who weigh below 2 ¾ pounds at birth could have problems seeing well. This is something Michelle T. Cabrera, an associate professor of ophthalmology at the University of Washington School of Medicine and a pediatric ophthalmologist at Seattle Childrens, wants to help fix. She is using handheld, swept source optical coherence tomography in a study of 50 premature infants. The device obtains high-resolution, cross-sectional images of the vitreous in the babies’ eyes. The vitreous is the eye’s gel-like filling. The pictures Cabrera is taking can show fine ...

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    19. OCT-Guided Percutaneous Coronary Intervention In Bifurcation Lesions

      OCT-Guided Percutaneous Coronary Intervention In Bifurcation Lesions

      Coronary artery bifurcation lesions remain challenging despite significant advancements in stent technology and development of specific bifurcation stenting approaches. Optical coherence tomography (OCT) is the intracoronary imaging technique with the highest resolution and can generate automatically contoured lumen areas across the variable geometry of bifurcation lesions. Knowledge of plaque severity and composition facilitates planning of the best strategy for percutaneous coronary intervention (PCI) and stenting. In particular, the provisional stent strategy preferred in this context can be modified when there is high risk of side-branch compromise at the ostium after main vessel stenting. OCT is unique because it allows the ...

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      Mentions: Carlo Di Mario
    20. Avinger Provides Third Quarter 2018 Shareholder Update

      Avinger Provides Third Quarter 2018 Shareholder Update

      Avinger, Inc. (NASDAQ: AVGR), a commercial-stage medical device company that designs and develops the first-ever image-guided, catheter-based system that diagnoses and treats patients with peripheral artery disease (PAD), today reported results for the third quarter ended September 30, 2018. Third Quarter and Recent Highlights ● Achieved revenue of $2.0 million for the third quarter of 2018 ● Announced in September that physicians at 35 sites globally have successfully treated over 200 patients with the next-generation Pantheris image-guided atherectomy system ● Submitted a new 510(k) application to the U.S Food & Drug Administration (FDA) in August for the Pantheris SV (Small Vessel ...

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      Mentions: Avinger
    21. Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Importance The change in the anatomical dimensions over time and the effect on diurnal intraocular pressure (DIOP) following laser peripheral iridotomy is poorly understood. Background To evaluate change over time in anterior chamber angle anatomy following laser peripheral iridotomy (LPI) in patients with primary angle closure compared to control eyes. Additionally, the effect of LPI on DIOP fluctuation was investigated. Design Longitudinal, prospective, double‐randomized research study. Participants Adults with suspected angle closure or angle closure diagnosis referred to hospital services in the United Kingdom. Methods Thirty‐nine patients newly diagnosed with bilateral primary angle closure/suspects (PAC/PACS) received ...

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    22. Optical Coherence Tomography and Corpus Callosum Index in Cognitive Assessment of Multiple Sclerosis Patients

      Optical Coherence Tomography and Corpus Callosum Index in Cognitive Assessment of Multiple Sclerosis Patients

      Background: Multiple Sclerosis (MS) is a neurodegenerative disease of central nervous system. Different approaches have been developed to study MS progression and cognitive dysfunction as the major symptom of the disease. The current study compared Optical Coherence Tomography (OCT) and Corpus Callosum Index (CCI) for the early evaluation of cognitive dysfunction in MS patients. Objectives: The aim of this study is to compare OCT with CCI in early evaluation of cognitive dysfunction in MS patients. Materials & Methods: In this study, a total number of 30 patients with relapsing-remitting MS referring to outpatient clinic of Shafa Hospital (Kerman, Iran) were selected ...

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    23. Feature-oriented singular value shrinkage for optical coherence tomography image

      Feature-oriented singular value shrinkage for optical coherence tomography image

      Optical coherence tomography (OCT) is a non-invasive optical imaging modality that has been widely used in the field of medical diagnosis. However, OCT images are often degraded by speckle noise. To address this problem, this paper proposes a two-stage feature-oriented singular value shrinkage algorithm in a low-rank approximation framework, for speckle noise reduction and contrast enhancement of intra-retinal layers of OCT images. First, a weighted absolute distance is employed to find nonlocal similar patches that exhibit high correlation to a given reference one. Next, the singular values of the group matrix formed by similar patches are shrunk by mixed thresholding ...

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    24. The Validity of Optical Coherence Tomography Angiography as a Screening Test for the Early Detection of Retinal Changes in Patients with Hydroxychloroquine Therapy

      The Validity of Optical Coherence Tomography Angiography as a Screening Test for the Early Detection of Retinal Changes in Patients with Hydroxychloroquine Therapy

      Purpose : The aim of this study was to quantitatively compare both the vessel density of macular capillary plexuses and the foveal avascular zone (FAZ) areas of patients receiving hydroxychloroquine (HCQ) therapy for more than 5 years while using age- and sex- matched controls. Methods : The patients undergoing HCQ who were screened for toxic effects were evaluated. The FAZ parameters included the area, perimeter, and the acircularity index. The foveal density and vessel density values of both the superficial (SCP) and deep capillary plexuses (DCP) were measured using optical coherence tomography angiography (OCTA). Results : This study included 80 eyes of 40 ...

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