1. All Articles

    1-24 of 16252 1 2 3 4 ... 676 677 678 »
    1. Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      The authors report a new, non-invasive diagnostic method in the diagnosis of retinal cavernous hemangioma (RCH). A 6-year-old girl was referred for a non-clearing retinal hemorrhage of 6 months’ duration. Fourier-domain optical coherence tomography (FD-OCT) showed an intraretinal lesion with cystic-like internal appearance. Optical shadowing was present, preventing establishment of any subretinal component to the lesion. Swept-source OCT (SS-OCT) showed an intraretinal lesion consisting of a group of clearly defined grape-like caverns with overlying preretinal tissue. Wide-field fundus fluorescein angiography (WF-FFA) confirmed the diagnosis of RCH. SS-OCT was superior to FD-OCT in showing the internal anatomy of the RCH and ...

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    2. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 – 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the ...

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    3. Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) quickly produces images that resemble conventional pathology images. We examined endometrium in an intra-operative like fashion (more than forty samples). FFOCT-imaged endometrium was recognizable to pathologists and compared favorably with microscopy of the same samples. Additional image enhancements and acquisition techniques were explored and may improve interpretation accuracy. Wider evaluation of images is ongoing, using more pathologist subjects. FFOCT may revolutionize pathology practice in the future by permitting rapid diagnosis and in vivo diagnosis; this is potentially a disruptive new diagnostic technique in pathology.

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    4. Investigation of the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in reproductive medicine

      Investigation of the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in reproductive medicine

      Introduction and objective: In Europe, nearly every sixth couple in the reproductive age is involuntarily childless. In about 30%, both male and female reveal fertility problems. In about 10% of infertile men, azoospermia is the underlying cause. As conventional therapeutic options are limited, surgical testicular sperm extraction (TESE) is necessary to obtain sperms for assisted reproductive techniques. Regarding the females, up to 30% of all idiopathic infertilities are due to alterations of the uterine tube So far, no imaging technique, which does not require any labelling, is available to evaluate the male and female genital tract at a microscopic level ...

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    5. The use of optical coherence tomography in maxillofacial surgery

      The use of optical coherence tomography in maxillofacial surgery

      The ever-evolving medical field continues to trend toward less invasive approaches to the diagnosis and treatment of pathological conditions. Basic sciences research has allowed for improved technologies that are translated to the clinical sciences. Similarly, advancements in imaging modalities continue to improve and their applications become more varied. As such, surgeons and pathologists are able to depend on smaller samples for tissue diagnosis of pathological disease, where once large sections of tissue were needed. Optical coherence tomography (OCT), a high-resolution imaging technique, has been used extensively in different medical fields to improve diagnostic yield. Its use in dental fields, particularly ...

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    6. Descemet Membrane Endothelial Keratoplasty: Intraoperative and Postoperative Imaging Spectral-Domain Optical Coherence Tomography

      Descemet Membrane Endothelial Keratoplasty: Intraoperative and Postoperative Imaging Spectral-Domain Optical Coherence Tomography

      We describe a case report of using the same handheld spectral-domain anterior segment optical coherence tomography (ASOCT) for rapid intraoperative and postoperative imaging in a case of Descemet membrane endothelial keratoplasty (DMEK). A 67-year-old woman, with Fuchs dystrophy and corneal decompensation, underwent DMEK with intraoperative ASOCT imaging using the handheld Envisu spectral domain ASOCT system (Bioptigen, Inc., Morrisville, NC, USA). We found that this easy-to-use portable system with handheld probe allowed for rapid imaging of the anterior segment during donor manipulation to visualize the orientation of the DMEK donor, as well as to confirm the initial adhesion of the DMEK ...

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    7. Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Purpose: To compare the vascular response after paclitaxel-coated nitinol drug-eluting stent (Zilver PTX) implantation for superficial femoral artery lesions after 6 and 12 months using optical coherence tomography (OCT). Methods: Serial OCT examinations were performed in 5 patients (4 men; mean age 78.4±6.8 years) with 9 Zilver PTX stents at 6- and 12-month follow-up. Variables evaluated included neointimal thickness and apposition on each strut, the incidence of extrastent lumen (ESL), peristrut low-intensity area (PLIA), and neovascularization at 1-mm intervals. Results: A total of 249 matched cross-section images were evaluated and included 4788 and 4826 struts at 6 ...

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    8. Retinal development in albinism: a prospective study using optical coherence tomography in infants and young children

      Retinal development in albinism: a prospective study using optical coherence tomography in infants and young children

      Background Retinal development normally involves migration of the inner retinal layers away from the fovea, migration of the cone photoreceptors into the fovea, and elongation of the photoreceptors over time. This process is arrested prematurely in albinism. However, because retinal development continues at least until the age of 4 years, when development arrests in albinism is uncertain. In this study we outlined the time course of retinal development in children with albinism. Methods We studied 44 children with a diagnosis of albinism and 223 control participants. All participants were aged between 0 and 6 years. We obtained 219 mixed cross-sectional ...

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    9. Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      As part of the Erlangen Graduate School in Advanced Optical Technologies ( SAOT ) granted by the German Excellence Initiative for Cutting-Edge Research at Institutions of Higher Education, the research group of SAOT Juniorprofessor Maximilian Waldner invites applications for a Postdoc Position Research focus of the Lab/Research projects: The research group focuses on the implementation of new optical technologies for the diagnosis and treatment of gastrointestinal diseases. Current projects evaluate the potential of multiphoton microscopy, optical coherence tomography, hyper-spectral imaging techniques, Raman spectroscopy etc. in preclinical models of inflammatory diseases and cancer of the gastrointestinal tract. Prerequisites for the position are ...

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    10. Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?

      Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?

      In isolated airway smooth muscle (ASM) strips, an increase or decrease in ASM length away from its current optimum length causes an immediate reduction in force production followed by a gradual time-dependent recovery in force, a phenomenon termed length adaptation. In situ, length adaptation may be initiated by a change in transmural pressure (Ptm), which is a primary physiological determinant of ASM length. The present study sought to determine the effect of sustained changes in Ptm and therefore, ASM perimeter, on airway function. We measured contractile responses in whole porcine bronchial segments in vitro before and after a ...

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    11. Optical coherence tomography for the diagnosis and evaluation of human otitis media

      Optical coherence tomography for the diagnosis and evaluation of human otitis media

      We report the application of optical coherence tomography (OCT) to the diagnosis and evaluation of otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard and pneumatic otoscopy, are limited to visualizing the surface of the tympanic membrane (TM), OCT effectively reveals the depth-resolved microstructure below the TM with very high spatial resolution, with the potential advantage of its use for diagnosing different types of OM. We examined the use of 840-nm spectral domain-OCT (SD-OCT) clinically, using normal ears and ears with the adhesive and effusion types of OM. Specific features were identified in two-dimensional OCT images of abnormal ...

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    12. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

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    13. Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      The ARVO Special Interest Group meeting on "Optical Coherence Tomography Angiography of the Eye" wwill take place during ARVO 2015 meeting, in Denver Colorado. SIG Session Number: 125 Session Date/Start Time: M ay 3, 2015 from 1:30 PM to 3:00 PM Room: 2C/3C Mile High Ballroom Organizers: David Huang, Philip Rosenfeld, Moderators: Carmen Puliafito, James Fujimoto Participating in the Technology panel: David Huang, Yoshiaki Yasuno, Ruikang Wang, Yali Jia. Clinical panel 1: Phil Rosenfeld, SriniVas Sadda, Jay Duker, Ching-Jygh Chen, Bruno Lumbroso Clinical panel 2: Marco Rispoli, Andre Romano, Richard Rosen, Richard Spaide, Giovanni Staurenghi, Nadia ...

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    14. Angular scan optical coherence tomography imaging and metrology of spherical gradient refractive index preforms

      Angular scan optical coherence tomography imaging and metrology of spherical gradient refractive index preforms

      The fabrication of high-performance spherical gradient refractive index (S-GRIN) optics requires nondestructive metrology techniques to inspect the samples. We have developed an angular-scan, swept-source-based, Fourier-domain optical coherence tomography system centered at 1318 nm with 5 mm imaging depth capable of 180̊ polar scan and 360̊ azimuthal scan to investigate polymeric S-GRIN preforms. We demonstrate a method that enables simultaneous mapping of the group optical thickness, physical thickness, the radially-averaged group refractive index, and the transmitted wavefront of the S-GRIN preforms. The angular scan OCT imaging and metrology enables direct visualization, molding uniformity characterization, and optical property evaluations of the preforms ...

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    15. Retinal angiography with real-time speckle variance optical coherence tomography

      Retinal angiography with real-time speckle variance optical coherence tomography

      This report describes a novel, non-invasive and label-free optical imaging technique, speckle variance optical coherence tomography (svOCT), for visualising blood flow within human retinal capillary networks. This imaging system uses a custom-built swept source OCT system operating at a line rate of 100 kHz. Real-time processing and visualisation is implemented on a consumer grade graphics processing unit. To investigate the quality of microvascular detail acquired with this device we compared images of human capillary networks acquired with svOCT and fluorescein angiography. We found that the density of capillary microvasculature acquired with this svOCT device was visibly greater than fluorescein angiography ...

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    16. Posterior Vitreous Mobility Delineated by Tracking of Optical Coherence Tomography Images in Eyes with Idiopathic Macular Holes

      Posterior Vitreous Mobility Delineated by Tracking of Optical Coherence Tomography Images in Eyes with Idiopathic Macular Holes

      Purpose To demonstrate the posterior vitreous mobility following eye movements in patients forming macular holes, using an optical coherence tomography (OCT) eye tracking system. Design Prospective consecutive interventional case series. Methods Twenty four eyes of seventeen consecutive patients with idiopathic macular hole and the remaining fellow eyes were recruited. Following acquisition of baseline fundus scans, all patients were instructed to perform sets of standardized full excursion, vertical and horizontal eye movements. Immediately after each set of movements an OCT scan registered to the baseline fundus image was obtained using the eye tracking system. Three images were then overlaid using picture-editing ...

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    17. Automated detection of dentinal lesions in OCT images using the RKT transformation

      Automated detection of dentinal lesions in OCT images using the RKT transformation

      Several studies have shown that optical coherence tomography (OCT) can be used to measure the remaining enamel thickness and detect the location of subsurface lesions hidden under the sound enamel. The purpose of this study was to develop algorithms to enhance the visibility of subsurface structures such as hidden occlusal lesions and the dentinal-enamel junction. Extracted teeth with natural occlusal lesions were imaged with OCT with and without added high index fluids. A Rotating Kernel Transformation (RKT) nonlinear image processing filter was applied to PS-OCT images to enhance the visibility of the subsurface lesions under the sound enamel. The filter ...

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    18. Apices of maxillary premolars observed by swept source optical coherence tomography

      Apices of maxillary premolars observed by swept source optical coherence tomography

      Apicoectomy is performed for the management of apical periodontitis when orthograde root canal treatment is not possible or is ineffective. Prior to the surgery, cone beam computed tomography (CBCT) examination is often performed to evaluate the lesion and the adjacent tissues. During the surgical procedure, the root apex is resected and the resected surface is usually observed under dental operating microscope (DOM). However, it is difficult to evaluate the details and the subsurface structure of the root using CBCT and DOM. A new diagnostic system, swept source optical coherence tomography (SS-OCT), has been developed to observe the subsurface anatomical structure ...

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    19. Observation of the pulp horn by swept source optical coherence tomography and cone beam computed tomography

      Observation of the pulp horn by swept source optical coherence tomography and cone beam computed tomography

      Cone-beam computed tomography (CBCT) is one of the most useful diagnostic techniques in dentistry but it involves ionizing radiation, while swept source optical coherence tomography (SS-OCT) has been introduced recently as a nondestructive, real-time, high resolution imaging technique using low-coherence interferometry, which involves no ionizing radiation. The purpose of this study was to evaluate the ability of SS-OCT to detect the pulp horn (PH) in comparison with that of CBCT. Ten extracted human mandibular molars were used. After horizontally removing a half of the tooth crown, the distance from the cut dentin surface to PH was measured using microfocus computed ...

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    20. Signal processing of Spectral Domain Optical Coherence Tomography

      Signal processing of Spectral Domain Optical Coherence Tomography

      Medical imaging techniques that are found in hospitals are X-ray imaging, MRI, ultrasound imaging, CT scan. Recently, a lot of scientific research work is being carried out with the aim of the improvement of these methods and the discovery of new non-invasive techniques. As a result, a new optical imaging technique, called Spectral Domain Optical Coherence Tomography (SD-OCT) was proposed in the early 2000s. Optical Coherence Tomography (OCT) is an emerging imaging technique having resolution in the µm range and depth of imaging in the mm range. In this paper we have described the basic principle, theory, types of OCT ...

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    21. Feature Of The Week 03/01/15: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Feature Of The Week 03/01/15: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. In this study, the diagnostic value of 3-D OCT in comparison to 2-D OCT in the comprehensive grading of human cartilage degeneration is investigated. In total, 53 human osteochondral samples were harvested. The imaging was performed by obtaining a single B-scan image (2-D OCT) and by collecting 100 consecutive B-scan images to generate a volumetric data set (3-D OCT). OCT images were assessed qualitatively according to a modified version of the DJD classification. OCT images were assessed quantitatively by algorithm-based evaluation of ...

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    22. Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

      Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

      Objective: To analyze the retinal ganglion cell layer (RGL) by optical coherence tomography (OCT) in toxic and nutritional optic neuropathy and to correlate its thickness and volume with functional damage. Methods: We conducted an observational cross-sectional study in healthy subjects and in patients with toxic optic neuropathy observed in the Neuro-Ophthalmology Department of Central Lisbon Hospital Center. Complete ophthalmologic examination, OCT (Heidelberg Spectralis), and automated static perimetry were performed. Thickness and macular volume of RGL layer and inner plexiform layer were measured after manual segmentation. Results: The study included 16 eyes of 12 healthy subjects and 16 eyes of 8 ...

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