1. All Articles

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    1. Spectralis optical coherence tomography normal macular thickness in Egyptians

      Spectralis optical coherence tomography normal macular thickness in Egyptians

      Purpose The aim of this study was to determine the normative data of macular thickness in the Egyptian population and to assess the effect of different demographic data and ocular parameters on it using spectral-domain optical coherence tomography (SD-OCT). Patients and methods This cross-sectional study included 105 healthy Egyptian patients who underwent a comprehensive ophthalmic examination, including Spectralis SD-OCT scanning, at Alexandria Main University Hospital. One eye from each patient was chosen randomly to be included in the study. Macular thickness was calculated based on center thickness and nine areas that corresponded to the Early Treatment Diabetes Retinopathy Study map ...

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    2. To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors

      To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors

      Purpose . To analyze and describe corneal and conjunctival tumor thickness and internal characteristics and extension in depth and size and shape measured by two noninvasive techniques, anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Design . Systematic review. Methods . This systematic review is based on a comprehensive search of 4 databases (Medline, Embase, Web of Science, and Cochrane Library). Articles published between January 1, 1999, and December 31, 2015, were included. We searched for articles using the following search terms in various combinations: “optical coherence tomography”, “ultrasound biomicroscopy”, “corneal neoplasm”, “conjunctival neoplasm”, “eye”, “tumor” and “anterior segment tumors”. Inclusion ...

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    3. In Vivo Observation of Lens Regeneration in Rat Using Ultra-Long Scan Depth Optical Coherence Tomography

      In Vivo Observation of Lens Regeneration in Rat Using Ultra-Long Scan Depth Optical Coherence Tomography

      Purpose : To evaluate morphologic changes of lens regeneration in rats in vivo after extracapsular lens extraction (ECLE) by ultra-long scan depth optical coherence tomography (UL-OCT). Methods : A total of 42 Sprague-Dawley rats were used in this study. We performed ECLE on the right eyes of animals in the surgery group ( n = 34). Biomicroscopy and UL-OCT scans were carried out for the surgery group immediately (within 1 hour postoperatively) and at days 1 and 3, weeks 1 and 2, and months 1, 2, and 3 postoperatively. After in vivo examination, three animals of the surgery group were euthanized at each time ...

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    4. The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction

      The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction

      Objectives: The index of microcirculatory resistance (IMR) provides a reproducible assessment of the status of coronary microvasculature in patients with ST-elevation myocardial infarction (STEMI). Frequency-domain optical coherence tomography (FD-OCT) enables detailed assessment of the morphology of coronary plaque. We sought to determine the influence of the initial culprit coronary plaque anatomy within the infarct-related artery on IMR after stenting in STEMI. Patients and methods: In 25 STEMI patients IMR was measured immediately before and after stent implantation. FD-OCT imaging was performed at the same time points and atherothrombotic volume (ATV) before stenting, prolapsed+floating ATV after stenting and [DELTA]ATV ...

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    5. OCT Angiography Module for SPECTRALIS now available outside US

      OCT Angiography Module for SPECTRALIS now available outside US

      The SPECTRALIS ® expandable diagnostic imaging platform can be upgraded with the OCT Angiography Module to perform non-invasive, layer-by-layer examinations of flow in the vascular networks of the retina and choroid. The OCT Angiography Module can be added to new and existing upgradeable SPECTRALIS devices with the OCT2 Module. The multimodal imaging platform allows clinicians to compare OCT angiographies to other modalities such as structural OCT and dye-based angiographies as well as infrared, MultiColor and BluePeak images, dependent on the SPECTRALIS model. “In combination with other imaging modalities, OCT angiography enables a more comprehensive understanding of vascular abnormalities. The SPECTRALIS truly ...

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    6. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer. In this study, we scan axillary lymph nodes ...

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    7. Comparison Between an Electronic Mobile Device and Optical Coherence Tomography to Determine Cup-to-disc Ratio

      Comparison Between an Electronic Mobile Device and Optical Coherence Tomography to Determine Cup-to-disc Ratio

      his study was a non-inferiority trial with masked data analysis. Individuals ranging from 18 to 60 years from both genders that met the pre-defined criteria were included. This study was carried out in Recife at Clinica Oftalmologica Zona Sul and at Centro de Informatica-UFPE. Using both equipment, 5 vertical cup-to-disc ratio (VCDR) evaluations were performed for each eye of the individuals, under midriatic conditions. Evaluations were done by examiners who did not know previously results obtained from other equipment. Data was collected by the main researcher of this research. This study was approved by the ethics committee before it started ...

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    8. A pilot study to assess the morphology and progression of non-carious cervical lesions

      A pilot study to assess the morphology and progression of non-carious cervical lesions

      Objective This longitudinal pilot study aimed to morphologically and quantitatively investigate the progress of non-carious cervical lesions (NCCLs) by using swept-source optical coherence tomography (SS-OCT). Methods The samples examined comprised sets of NCCL epoxy resin replicas obtained from 10 lesions in 6 patients who attended annual dental visits over 4 or 5 years. SS-OCT images of the replicas were analyzed in terms of the maximum depth (D max ) and corresponding vertical width (VW) − using an image analyzer to estimate progression of the NCCLs over time. Results It was found that differences between wedge- and saucer-shaped lesions were morphologically distinguished well ...

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    9. Erasing the Line Between Imaging and Analyzing

      Erasing the Line Between Imaging and Analyzing

      As imaging and sensing technologies grow in both sophistication and accessibility, they do more than just gather data and produce images: They are research tools in their own right, providing scientists with the means to deepen our knowledge both about fundamental biological processes and about causes and progression of disease. Obtaining the images is only the first step. Significant research and clinical advances require new ways of analyzing the data. Current biomedical imaging and sensing technologies include computerized tomography, magnetic resonance imaging, optical coherence tomography, spectroscopy, and ultrasound, to name only a few. These technologies are at the intersection of ...

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    10. The challenge to detect and to treat vulnerable plaques and vulnerable patients

      The challenge to detect and to treat vulnerable plaques and vulnerable patients

      One of many “holy grails” of cardiology is to avoid the occurrence of acute coronary syndromes (ACS). It would be a remarkable improvement in the field if we could develop the capacity to identify the spots of the coronary vessels that are about to become unstable during the following weeks or months. This should be possible if we were able to prevent dissection, rupture or erosion of the coronary wall which usually causes an ACS [1-3]. It is said that this could possibly be realized by identifying those unstable coronary artery lesions that are more prone to result in future ...

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    11. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s, and thus, both 3D volumetric images, reaching up to 20mm × 20mm × 1.2mm, and en face internal fingerprint furrow pattern images could be obtained. Based upon the analyses of the ...

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    12. Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

      Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

      Aim: To image the radial peripapillary capillary (RPC) network with optical coherence tomography angiography (OCTA) and measure its capillary density (CD) in the normal human retina. Materials and Methods: Fifty-two normal participants underwent OCTA imaging with RTVue XR 100 Avanti OCT. The angioflow enface RPCs network was extracted from OCTA and 8 peripapillary sectors with a sector angle of 45 degrees were selected for quantitative analysis: superior nasal, superior temporal, temporal upper, temporal lower, nasal upper, nasal lower, inferior nasal, and inferior temporal. CD was measured within a 3.4-mm circle diameter around the optic nerve head (ONH) using the ...

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    13. Full-range ultrahigh-resolution spectral-domain optical coherence tomography in 1.7 µm wavelength region for deep-penetration and high-resolution imaging of turbid tissues

      Full-range ultrahigh-resolution spectral-domain optical coherence tomography in 1.7 µm wavelength region for deep-penetration and high-resolution imaging of turbid tissues

      For the first time, we developed a full-range ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) technique working in the 1.7 µm wavelength region. This technique allowed high-resolution, deep-tissue imaging. By using a supercontinuum source operating at a wavelength of 1.7 µm, an axial resolution of 3.6 µm in a tissue specimen was achieved. To enhance the imaging depth of UHR-SD-OCT, we performed full-range OCT imaging based on a phase modulation method. We demonstrated the three-dimensional (3D) imaging of a mouse brain with the developed system, and specific structures in the mouse brain were clearly visualized at depths ...

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    14. Green disease in optical coherence tomography diagnosis of glaucoma

      Green disease in optical coherence tomography diagnosis of glaucoma

      Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression.Recent findings: Conditions in which OCT color coding may be falsely negative (i.e., green disease) are identified. Early glaucoma in which retinal nerve fiber layer (RNFL) thickness and optic disc parameters, albeit labeled green, are asymmetric in both eyes may result ...

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      Mentions: Richard K. Lee
    15. Adaptive optics optical coherence tomography in glaucoma

      Adaptive optics optical coherence tomography in glaucoma

      Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT. The incorporation of AO into ophthalmic imaging modalities has enhanced OCT by improving image resolution and quality, particularly in the posterior ...

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    16. Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography

      Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography

      Intravascular optical coherence tomography (IVOCT) is an imaging technique that is used to analyze the underlying cause of cardiovascular disease. Because a catheter is used during imaging, the intensities can be affected by the catheter position. This work aims to analyze the effect of the catheter position on IVOCT image intensities and to propose a compensation method to minimize this effect in order to improve the visualization and the automatic analysis of IVOCT images. The effect of catheter position is modeled with respect to the distance between the catheter and the arterial wall (distance-dependent factor) and the incident angle onto ...

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    17. En Face Optical Coherence Tomography of Cystoid Macular Edema

      En Face Optical Coherence Tomography of Cystoid Macular Edema

      The honeycomb pattern of large and small cystoid abnormalities in the segmented en face swept-source optical coherence tomography (SS-OCT) section through the outer plexiform and inner nuclear layers of the retina is depicted in Figure , A. Intraretinal cystoid spaces in the conventional B-scan SS-OCT image are shown in Figure , B. The en face reconstruction demonstrates the exact nature, extent, and anatomical configuration of the pathology. Cystoid macular edema is a common sequela of intraocular inflammation resulting from many causes like intermediate uveitis and cataract surgery. The commercially available SS-OCT imaging technology has an axial resolution as high as 1 µm ...

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    18. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100′000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies. The optical properties of the eye allow the imaging of the ...

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    19. Selected Topics in Optical Coherence Tomography (Textbook)

      Selected Topics in Optical Coherence Tomography (Textbook)

      This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.

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      Mentions: Gangjun Liu
    20. Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Purpose : To evaluate the effects of phacoemulsification cataract surgery on Schlemm's canal (SC) using swept-source optical coherence tomography (OCT). Methods : Patients with a senile cataract were included. The SC area and diameter were checked by OCT at the baseline and 1 day, 1 week, 1 month, and 6 months after the cataract surgery. Multivariate linear regression analysis was performed for predictors of change in the mean SC area and diameter. Results : Twenty-five eyes (25 patients) were included in the final analysis. After the cataract surgery, there was a significant increase in the SC area and diameter, and a decrease ...

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    21. In Vivo optical coherence tomography visualization of intraplaque neovascularization at the site of coronary vasospasm: a case report

      In Vivo optical coherence tomography visualization of intraplaque neovascularization at the site of coronary vasospasm: a case report

      Background Coronary plaques in patients with coronary vasospastic angina have been characterized by diffuse intima-media thickening with homogeneous fibrous tissue, without confluent necrotic tissue. However, coronary vasospasm can trigger coronary thrombosis, and may play an important role in the pathogenesis of acute coronary syndromes, though the precise morphological mechanisms underlying this process remain unclear. Case presentation A 43-year-old man with a history of multivessel coronary vasospastic angina had been treated with long-acting diltiazem and fluvastatin since 2004. Eleven years later, following 1 month of medication nonadherence, he experienced recurrence of rest angina and myocardial infarction, with elevated high-sensitivity troponin T ...

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    22. Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study

      Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study

      Objective: The addition of cystatin C to creatinine in calculating the estimated glomerular filtration rate (eGFR) is known to improve the risk prediction for cardiovascular events. We sought to investigate the associations between eGFRs calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and coronary plaque phenotype by optical coherence tomography. Patients and methods: We analyzed 181 nonculprit plaques from 116 coronary artery disease patients. For each patient, the eGFR was calculated using the CKD-EPIcreatinine, CKD-EPIcystatin C, and CKD-EPIcombination equations. Patients were divided into three categories according to the eGFR calculated by each equation (>=90, 60-89, and <60 ml ...

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    23. Optical Coherence Tomography (OCT) Intravascular Ultrasound (IVUS) Dual Imaging

      Optical Coherence Tomography (OCT) Intravascular Ultrasound (IVUS) Dual Imaging

      Both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are standardly used and have been extensively studied separately to guide percutaneous coronary intervention and improve long-term outcomes. In this study, the investigators aim to directly compare high-definition IVUS images to OCT in the same patients to determine the differences between each modality as they relate to imaging coronary pathology, with the goal of determining which modality is most appropriate in particular clinical scenarios.

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    24. Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Purpose To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. Methods This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. Results Percentages of non-gradable images for the outline of foveal avascular zone ...

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