1. All Articles

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    1. Global Markets and Technologies for Optical Coherence Tomography (OCT) – Focus on Full Field and Optical Delay

      Global Markets and Technologies for Optical Coherence Tomography (OCT) – Focus on Full Field and Optical Delay

      BCC’s aim in conducting this study is to offer synopsis of the current and future characteristics of the global market for optical coherence tomography (OCT). The key objective is to present a comprehensive analysis and future trend and research of OCT as an important tool for the usage of this technique in imaging. This report explores present and future different OCT techniques and their usage and developments within the OCT market. This report includes different types of OCT techniques such as time domain and large-field high-speed polarization sensitive system, Fourier domain or spectral domain and time-encoded frequency domain or ...

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    2. High-speed ultra-broad tuning MEMS-VCSELs for imaging and spectroscopy

      High-speed ultra-broad tuning MEMS-VCSELs for imaging and spectroscopy

      In the last 2 years, the field of micro-electro-mechanical systems tunable vertical cavity surface-emitting lasers (MEMS-VCSELs) has seen dramatic improvements in laser tuning range and tuning speed, along with expansion into unexplored wavelength bands, enabling new applications. This paper describes the design and performance of high-speed ultra-broad tuning range 1050nm and 1310nm MEMS-VCSELs for medical imaging and spectroscopy. Key results include achievement of the first MEMS-VCSELs at 1050nm and 1310nm, with 100nm tuning demonstrated at 1050nm and 150nm tuning at shown at 1310nm. The latter result represents the widest tuning range of any MEMS-VCSEL at any wavelength. Wide tuning range ...

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    3. Ophthalmic engineering: the development of novel instrumentation to further research in the field

      Ophthalmic engineering: the development of novel instrumentation to further research in the field

      The principle theme of this thesis is the advancement and expansion of ophthalmic research via the collaboration between professional Engineers and professional Optometrists. The aim has been to develop new and novel approaches and solutions to contemporary problems in the field. The work is sub divided into three areas of investigation; 1) High technology systems, 2) Modification of current systems to increase functionality, and 3) Development of smaller more portable and cost effective systems. High Technology Systems: A novel high speed Optical Coherence Tomography (OCT) system with integrated simultaneous high speed photography was developed achieving better operational speed than is ...

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    4. Assessment and In Vivo Scoring of Murine Experimental Autoimmune Uveoretinitis Using Optical Coherence Tomography

      Assessment and In Vivo Scoring of Murine Experimental Autoimmune Uveoretinitis Using Optical Coherence Tomography

      Despite advances in clinical imaging and grading our understanding of retinal immune responses and their morphological correlates in experimental autoimmune uveoretinitis (EAU), has been hindered by the requirement for post-mortem histology. To date, monitoring changes occurring during EAU disease progression and evaluating the effect of therapeutic intervention in real time has not been possible. We wanted to establish whether optical coherence tomography (OCT) could detect intraretinal changes during inflammation and to determine its utility as a tool for accurate scoring of EAU. EAU was induced in C57BL/6J mice and animals evaluated after 15, 26, 36 and 60 days. At ...

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    5. Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion

      Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion

      Purpose To evaluate subfoveal choroidal thickness in patients with central retinal vein occlusion (CRVO) using enhanced depth imaging optical coherence tomography. Design Retrospective observational study. Methods We measured bilateral subfoveal choroidal thickness, averaged for 100 scans, in 36 patients (mean age, 66 ± 15 years; 26 women and 10 men) with unilateral CRVO by using the enhanced depth imaging methods of the Spectralis optical coherence tomography system. Twenty-two patients were treated with intravitreal bevacizumab (1.25 mg/0.05 mL), and subfoveal choroidal thickness was measured before and after treatment. Statistical analysis was performed to compare subfoveal choroidal thickness of CRVO ...

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    6. Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive techniques, but the information obtained by visual fundus examination can be limited. We therefore evaluated the efficacy of optical coherence tomography (OCT) and electroretinography (ERG) to monitor pathological and functional changes of the retina in vivo. OCT imaging and ERG recording as a measure of visual function were compared with visual fundoscopic imaging and histology findings in the same mouse. Our results showed that OCT imaging of the retina was well correlated with clinical and histological observations in mice during ...

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    7. Optical coherence tomography biospeckle imaging for fast monitoring varying surface responses of a plant leaf under ozone stress

      Optical coherence tomography biospeckle imaging for fast monitoring varying surface responses of a plant leaf under ozone stress

      In this study, Optical Coherence Tomography (OCT) was used to investigate the effect of short term ozone exposure on both front and back surfaces of the leaves of Allium tuberosum plant. Plant leaves were subjected to treat with 240ppb level of ozone, and imaging data were acquired from back and front surfaces of the leaves. Variations of the biological activations were monitored based on the biospeckles. Standard deviations (SD) of OCT temporal signal at each point were calculated and used to visualize the effect of ozone exposure. Leaf back surface showed higher SDs in biospeckle OCT signal in comparison to ...

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    8. Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Michelson Diagnostics Press Release - In what is believed to be the first ever study to investigate OCT (Optical Coherence Tomography) imaging of skin cancers in the eyelids and skin surrounding the eye, the Dept of Opthalmology, Maidstone and Tunbridge Wells NHS Trust have shown that OCT scanning can accurately reveal the margins of tumours. The study, which was conducted using the market leading VivoSight OCT scanner manufactured by Michelson Diagnostics, showed a positive correlation between tumour margins located using OCT and histology, the 'gold standard'. This breakthrough could ultimately lead to routine use of OCT scanning to plan delicate eyelid ...

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    9. Neovascular Glaucoma Induced by Peripheral Retinal Ischemia in Neurofibromatosis Type 1: Management and Imaging Features

      Neovascular Glaucoma Induced by Peripheral Retinal Ischemia in Neurofibromatosis Type 1: Management and Imaging Features

      Purpose: To report the case of a young patient affected by neurofibromatosis 1 (NF-1) with peripheral retinal ischemia-induced neovascular glaucoma and the peculiar spectral-domain optical coherence tomography (SD-OCT) features. Material and Methods: A 13-year-old boy affected by NF-1, as diagnosed according to established criteria, was referred with a diagnosis of hypertensive uveitis in his left eye. He underwent a complete ophthalmic examination and comprehensive blood work with viral and immunological tests. The case was documented with fluorescein angiography (FA) and SD-OCT. When the intraocular pressure (IOP) of the left eye decreased and the cornea cleared, FA revealed retinal ischemia and ...

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    10. Anterior Segment Optical Coherence Tomography: Assisted Topographic Corneal Epithelial Thickness Distribution Imaging of a Keratoconus Patient

      Anterior Segment Optical Coherence Tomography: Assisted Topographic Corneal Epithelial Thickness Distribution Imaging of a Keratoconus Patient

      PURPOSE: To evaluate safety, efficacy and ease of measurement of epithelial thickness in a keratoconic patient based on anterior segment optical coherence tomography (AS-OCT). METHODS: A 25-year-old male patient, previously diagnosed with keratoconus, with highly asymmetric manifestation among the two eyes, was subjected to AS-OCT corneal epithelial imaging. We investigated epithelial thickness and epithelial topographic thickness distribution. RESULTS: Mean epithelial thickness was 51.97 ± 0.70 for the less affected right eye (OD), and 55.65 ± 1.22 for the more affected left eye (OS). Topographic epithelial thickness variability for the OD was 1.53 ± 0.21 μm, while for ...

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    11. Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

      Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

      Objectives This study sought to elucidate the underlying mechanism through which drug-eluting balloons (DEB) restore coronary blood flow, by assessing the coronary vessel before, immediately after, and at 6-month follow-up with angiography, optical coherence tomography (OCT), and fractional flow reserve (FFR). Background In-stent restenosis (ISR) treatment remains challenging. Drug-eluting balloons have been shown to be a valid treatment option in several studies. These studies focused on efficiency of the device, whereas the mechanisms of action of DEB in ISR treatment have not been investigated. Methods In this prospective, single-center observational study, patients with ISR were treated with a second-generation DEB ...

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    12. Optical coherence tomography system and method therefor

      Optical coherence tomography system and method therefor

      A method for increasing the imaging rate for an optical coherence tomography system is disclosed. The method comprises generating an interferometric signal by interrogating each of M image points on a sample with a plurality of wavelength bands that are collectively spectrally interleaved, time encoding the interferometric signal, and sampling the time-encoded interferometric signal at a single detector.

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    13. Method and apparatus for detecting contour data and/or optical characteristics of a three-dimensional semitransparent object

      Method and apparatus for detecting contour data and/or optical characteristics of a three-dimensional semitransparent object

      A method for detecting contour data of a three-dimensional object, where a grid of illumination points of a multi-point illumination is projected onto the object using an optical device and the illumination points are then projected back onto a sensor containing pixels. In order to improve signal-noise ratio and reduce background signal, it is proposed that a grid of illumination points of at least two multi-point illuminations are projected onto the object, that the beams of the illuminating points of are modulated in intensity and that a frequency-selective and/or phase-selective detection is performed of mutually associated first and second ...

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    14. Apparatus and method for caries detection

      Apparatus and method for caries detection

      An apparatus for imaging a tooth has at least one illumination source for providing an incident light having a first spectral range for obtaining a reflectance image of the tooth and a second spectral range for exciting a fluorescence image of the tooth. A first polarizer having a first polarization axis and a compensator in the path of the incident light of the first spectral range are disposed to direct light toward the tooth. A second polarizer is disposed to direct light obtained from the tooth toward a sensor and has a second polarization axis that is orthogonal to the ...

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    15. First Human Clinical Images Available with OCTIS™ Thanks to Tomophase Corporation and the Thoraxklinik, University of Heidelberg

      First Human Clinical Images Available with OCTIS™ Thanks to Tomophase Corporation and the Thoraxklinik, University of Heidelberg

      Tomophase Corporation, a leading developer of minimally invasive optical coherence tomography (OCT) tissue imaging devices, announced today that the Thoraxklinik at the University of Heidelberg, Germany has taken the first OCTIS images in clinical patients with the Tomophase OCT Imaging System (OCTIS™). On Tuesday, May 7th Tomophase OCTIS was used for the first time to examine the airways of a patient undergoing bronchoscopy at the Thoraxklinik. The following day another patient was examined. (Courtesy of the Thoraxklinik, University of Heidelberg) The clinicians were quite intrigued of the results and plan to do further work in due course. The Tomophase OCTIS ...

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    16. The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      Purpose To report and analyze the spectral-domain optical coherence tomography (SD-OCT) features of the posterior pole and papillomacular fold (PMF) in posterior microphthalmos (PM) in relation to axial length of the globe and corneal power. Design Comparative case series. Participants Forty eyes of 20 PM patients and 70 eyes of 35 age-matched controls. Methods All PM and control eyes underwent a full biometric evaluation, including axial length and corneal power measurements, and macular SD-OCT. In addition, a novel SD-OCT marker of the posterior pole curvature, termed the posterior pole curvature index (PPCI), was measured along both the vertical and horizontal ...

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    17. Use of optical coherence tomography to guide treatment of an undeployed stent trapped in the right coronary artery to cover a proximal stent outflow dissection

      Use of optical coherence tomography to guide treatment of an undeployed stent trapped in the right coronary artery to cover a proximal stent outflow dissection

      A 73 year old man with a background history of hypercholesterolaemia, type II diabetes, and peripheral vascular disease presented with Canadian Cardiac Society (CCS) class III symptoms. ECG revealed no significant changes and high-sensitivity troponin was negative. Further risk stratification with an exercise stress test was positive (2mm J-point ST depression II, III, AVF), and he was referred for diagnostic coronary angiography.

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    18. A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      Accurate non-invasive assessment of tissue elasticity in vivo is required for early diagnostics of many tissue abnormalities. We have developed a focused air-pulse system that produces a low-pressure and short-duration air stream, which can be used to excite transient surface waves (SWs) in soft tissues. System characteristics were studied using a high-resolution analog pressure transducer to describe the excitation pressure. Results indicate that the excitation pressure provided by the air-pulse system can be easily controlled by the air source pressure, the angle of delivery, and the distance between the tissue surface and the port of the air-pulse system. Furthermore, we ...

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    19. Feature Of The Week 5/19/13: Using Optical Coherence Tomography For Anti-Spoof Fingerprint Detection

      Feature Of The Week 5/19/13: Using Optical Coherence Tomography For Anti-Spoof Fingerprint Detection

      Fingerprint biometrics, including automated fingerprint identification systems (AFIS), currently occupy two-thirds of the biometric market and are expected to remain the dominant player in this area. The technology can be integrated into small, compact devices and the instruments are relatively fast. However, the overall success of using fingerprints for identification and verification purposes greatly depends upon the quality of the fingerprints initially enrolled. For example, fingerprints captured from older people are significantly lower quality than those from younger people due primarily to ridge-wearing and difficulty of interacting effectively with conventional fingerprint scanners. The ramification is that the problem of obtaining ...

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    20. Accurate prediction of collapse temperature using optical coherence tomography-based freeze-drying microscopy

      Accurate prediction of collapse temperature using optical coherence tomography-based freeze-drying microscopy

      The objective of this study was to assess the feasibility of developing and applying a laboratory tool that can provide three-dimensional product structural information during freeze-drying and which can accurately characterize the collapse temperature ( T c ) of pharmaceutical formulations designed for freeze-drying. A single-vial freeze dryer coupled with optical coherence tomography freeze-drying microscopy (OCT–FDM) was developed to investigate the structure and T c of formulations in pharmaceutically relevant products containers (i.e., freeze-drying in vials). OCT–FDM was used to measure the T c and eutectic melt of three formulations in freeze-drying vials. The T c as measured by ...

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    21. Visualisation of a coronary stent presenting late mechanical failure in an aberrant left circumflex artery with coronary computed tomography angiography and optical coherence tomography

      Visualisation of a coronary stent presenting late mechanical failure in an aberrant left circumflex artery with coronary computed tomography angiography and optical coherence tomography

      A 56-year-old male was admitted with NSTEMI and underwent percutaneous coronary intervention with bare metal (cobalt-chromium) stent implantation (3.0×24 mm, 16 atm, post-dilated with 3.0×20 mm non-compliant balloon, 20 atm) in the mid segment of an anomalous circumflex artery (retroaortic course from the right sinus of Valsalva). The patient remained asymptomatic for five years post-procedure, when he presented with mild atypical chest pain. Myocardial stress perfusion scintigraphy detected no transient ischaemia; however, due to his persisting symptoms, a coronary computed tomography angiography was performed. This revealed restenosis and chronic recoil in the implanted stent (Online Figure ...

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    22. Real-Time Subglottic Stenosis Imaging Using Optical Coherence Tomography in the Rabbit

      Real-Time Subglottic Stenosis Imaging Using Optical Coherence Tomography in the Rabbit

      Importance Subglottic stenosis (SGS) is a severe, acquired, potentially life-threatening disease that can be caused by endotracheal tube intubation. Newborns and neonates are particularly susceptible to SGS owing to the small caliber of their airway. Objective To demonstrate optical coherence tomography (OCT) capabilities in detecting injury and scar formation using a rabbit model. Optical coherence tomography may provide a noninvasive, bedside or intensive care unit modality for the identification of early airway trauma with the intention of preventing progression to SGS and can image the upper airway through an existing endotracheal tube coupled with a small fiber-optic probe. Design Rabbits ...

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    23. Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains

      Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains

      Spectral domain optical coherence tomography (SD-OCT) has recently been established as a method for in vivo imaging of fundus and retina in the mouse. It enables more effective studies of retinal diseases including investigations of etiopathologic mechanisms. In order to learn more about longitudinal fundus development and to enable recognition of disease-associated irregularities, we performed confocal scanning laser ophthalmoscopy (cSLO) and SD-OCT measurements in the inbred strains C57BL/6J, C3HeB/FeJ, FVB/NCrl, BALB/cByJ, and 129S2/SvJ when they were between 2 and 6 months of age. In general, cSLO and SD-OCT data did not reveal sex-specific or unilateral ...

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  3. Optical Coherence Tomography News

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