1. All Articles

    1-24 of 22016 1 2 3 4 ... 916 917 918 »
    1. Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Acute coronary syndrome (ACS) is the main cause of death worldwide and the leading cause of disease burden in high-income countries. ACS refers to a constellation of clinical symptoms that are compatible with acute myocardial ischemia. It describes a spectrum of clinical manifestations that result from a common pathophysiological process. The most common cause of ACS are rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis. It was thought that a high-resolution imaging modality would be ideal to detect high-risk plaques before their disruption and the formation of an ...

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    2. Automatic Identification of Intraretinal Cystoid Regions in Optical Coherence Tomography

      Automatic Identification of Intraretinal Cystoid Regions in Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is, nowadays, one of the most referred ophthalmological imaging techniques. OCT imaging offers a window to the eye fundus in a non-invasive way, permitting the inspection of the retinal layers in a cross sectional visualization. For that reason, OCT images are frequently used in the analysis of relevant diseases such as hypertension or diabetes. Among other pathological structures, a correct identification of cystoid regions is a crucial task to achieve an adequate clinical analysis and characterization, as in the case of the analysis of the exudative macular disease. This paper proposes a new methodology for the ...

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    3. Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture radar (SAR). Using numerical simulations and imaging experiments, we verified that this technique can maintain a diffraction-limited transverse resolution along a DOF that is ∼ 10 ∼10 times larger than the ...

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    4. Optical coherence tomography angiography in pre-perimetric open-angle glaucoma

      Optical coherence tomography angiography in pre-perimetric open-angle glaucoma

      Purpose To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. Methods Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated. Receiver operating characteristic curves for OCT angiography parameters were assessed. Results The flow index ( p = 0.021) and vessel density ( p = 0.001) were significantly lower in pre-perimetric glaucoma eyes versus normal ...

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    5. Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography

      Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography

      Background Central vision loss in diabetic retinopathy is commonly related to diabetic macular edema (DME). The objective of this study was to describe changes between consecutive visits on optical coherence tomography angiography (OCTA) of the foveal avascular zone (FAZ) in eyes with DME. Methods 20 eyes from 14 patients with DME were imaged on 2 successive clinic visits separated by at least 1 month. The mean interval between visits was 3.2 months. The only intervention used was intravitreal anti-VEGF in 11 eyes; the others were observed over time without treatment. Two different readers measured FAZ area using a pseudo-automated ...

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    6. Relationship between vessel diameter and depth measurements within the limbus using ultra-high resolution optical coherence tomography

      Relationship between vessel diameter and depth measurements within the limbus using ultra-high resolution optical coherence tomography

      To establish a relationship between the diameter and depth position of vessels in the superior and inferior corneo-scleral limbus using ultra-high resolution optical coherence tomography (UHR-OCT). Methods Volumetric OCT images of the superior and inferior limbus were acquired from 14 healthy subjects with a research-grade UHR-OCT system. Differences in vessel diameter and depth between superior and inferior limbus were analyzed using repeated measured ANOVA in SPSS and R. Results The mean (± SD) superior and inferior diameters were 29 ± 18 μm and 24 ± 18 μm respectively, and the mean (± SD) superior and inferior depths were 177 ± 109 μm and 207 ± 132 ...

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    7. Investigating the influence of organic matter composition on biofilm volumes in reverse osmosis using optical coherence tomography

      Investigating the influence of organic matter composition on biofilm volumes in reverse osmosis using optical coherence tomography

      Biofouling, a critical issue in membrane filtration, is influenced by several factors such as membrane characteristics and feed water quality. The organic matter (OM) composition is known to significantly influence biofilm formation, but few studies on this subject have been reported. Optical coherence tomography (OCT) allows direct monitoring of biofilm development on the membrane surface without the need for membrane autopsy. The purposes of the present study are 1) to quantify biofouling formation on a membrane surface using OCT; 2) to monitor the temporal variation of OM composition during membrane formation; and 3) to investigate the variation of OM composition ...

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    8. Microvascular changes after vitrectomy with internal limiting membrane peeling: an optical coherence tomography angiography study

      Microvascular changes after vitrectomy with internal limiting membrane peeling: an optical coherence tomography angiography study

      Purpose To evaluate superficial capillary plexus (SCP) changes occurring after internal limiting membrane (ILM) peeling for the treatment of idiopathic epiretinal membrane (ERM). Methods A total of 15 eyes of 15 patients affected by idiopathic ERM (eight males and seven females; mean age 59.8 ± 9.6 years) were enrolled in the study. Patients were treated with pars plana vitrectomy followed by ERM and ILM peeling. Subjects were evaluated at baseline and at the week-1 and month-1 follow-up visits. At each visit, patients were evaluated with a complete ophthalmologic evaluation, which included imaging with optical coherence tomography angiography. Results Overall ...

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    9. Automatic identification of side branch and main vascular measurements in intravascular optical coherence tomography images

      Automatic identification of side branch and main vascular measurements in intravascular optical coherence tomography images

      Automatic identification of side branch and main vascular measurements in IVOCT images take critical roles in pre-interventional decision making for coronary artery disease treatment. Very little works have been presented on these tasks. In this paper, we proposed a novel side branch identification algorithm which utilizes a newly defined global curvature feature to identify the ostium of side branch. Based on identification results, the main vascular can be segmented automatically for measurements. In the measurement of main vascular, the diameter of maximum inscribed circle of main vascular is proposed for the first time, which could be helpful in stent size ...

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    10. Motion of intracochlear structures measured with a commercial optical coherence tomography (OCT) system

      Motion of intracochlear structures measured with a commercial optical coherence tomography (OCT) system

      Most knowledge of the motion of cochlear structures has been limited to measurements through the round window at the extreme base of the cochlea or through a hole made in the cochlear capsule, which can modify cochlear mechanics. Optical coherence tomography (OCT) provides the ability to measure shape or motion of structures through a thin layer of tissue or bone. The motion of cochlear structures has been measured in the mouse cochlear apex without making an opening into the cochlea, using a custom OCT system. Here we describe intracochlear vibrometry using a commercial OCT system. Specimens were prepared by opening ...

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      Mentions: Thorlabs
    11. Comparison between choroidal thickness in normal and glaucomatous eyes using spectral-domain optical coherence tomography

      Comparison between choroidal thickness in normal and glaucomatous eyes using spectral-domain optical coherence tomography

      Purpose The aim of this study was to compare choroidal thickness in healthy and glaucomatous eyes using spectral-domain optical coherence tomography. Patients and methods This prospective study was carried out on patients recruited from the Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt, from April 2015 to April 2016. Informed consent was obtained from all participants. The studied participants were divided into two groups: group 1, which included 100 healthy eyes with normal intraocular pressure, and group 2, which included 100 juvenile and adult-onset primary open-angle glaucomatous eyes. All participants had undergone high-definition raster scanning using spectral-domain ...

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    12. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy

      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be presented that integrates optical coherence tomography that is spatially and temporally co-registered with laryngeal videoendoscopic technology through a common path probe. Optical coherence tomography is a non-contact, micron-resolution imaging technology ...

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    13. Frequency-domain optical coherence tomography plaque morphology in stable coronary artery disease: sex differences

      Frequency-domain optical coherence tomography plaque morphology in stable coronary artery disease: sex differences

      Background: The cause for discrepancy in the clinical presentation and outcome of coronary artery disease (CAD) between men and women is not established. Different prevalences of risk factors or specific sex-related atherosclerotic aspects have been advocated as possible explanations. We investigated coronary plaque morphology looking at possible differences in plaque vulnerability between men and women with stable CAD.

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    14. Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

      Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

      When using optical coherence tomography angiography (OCTA), the development of artifacts due to involuntary movements can severely compromise the visualization and subsequent quantitation of tissue microvasculatures. To correct such an occurrence, we propose a motion compensation method to eliminate artifacts from human skin OCTA by means of step-by-step rigid affine registration, rigid subpixel registration, and nonrigid B-spline registration. To accommodate this remedial process, OCTA is conducted using two matching all-depth volume scans. Affine transformation is first performed on the large vessels of the deep reticular dermis, and then the resulting affine parameters are applied to all-depth vasculatures with a further ...

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    15. Compact Optical Delay Line for More Efficient OCT Imaging from Gooch & Housego

      Compact Optical Delay Line for More Efficient OCT Imaging from Gooch & Housego

      Systems Technology Groups presents the G&H small form factor (SFF) delay line. The delay line was specifically designed for the exacting requirements of optical coherence tomography (OCT). OCT is an imaging modality, mainly used in biomedical applications. By using OCT, it is possible to take real-time, high resolution 3D images in a non-invasive manner. OCT is a technique that utilises optical interferometry in which one interferometer arm is the reference optical path and the other is the optical path to the sample being imaged. The technique relies on the precise length alignment between the paths of the two interfering ...

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      Mentions: Gooch & Housego
    16. Optical Coherence Tomography And Infrared Images Of Astrocytic Hamartomas Not Revealed By Funduscopy In Tuberous Sclerosis Complex

      Optical Coherence Tomography And Infrared Images Of Astrocytic Hamartomas Not Revealed By Funduscopy In Tuberous Sclerosis Complex

      Purpose: To detect, describe, and classify the morphologic characteristics of astrocytic hamartomas in tuberous sclerosis complex, using both spectral-domain optical coherence tomography (OCT) and infrared images. Methods: Ten subjects (20 eyes) with tuberous sclerosis complex underwent a complete ophthalmologic examination and multimodality imaging with spectral-domain OCT and infrared images. The imaging protocol included a 30°scan angle of the posterior pole and of the four quadrants. Line scans, detail, raster, and posterior pole patterns were used. The identified astrocytic hamartomas were described and characterized qualitatively and quantitatively. Results: Forty-four hamartomas were detected in 8 patients. In five cases, lesions were ...

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    17. Effect Of Intravitreal Ranibizumab On Ganglion Cell Complex And Peripapillary Retinal Nerve Fiber Layer In Neovascular AGE-RELATED Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Effect Of Intravitreal Ranibizumab On Ganglion Cell Complex And Peripapillary Retinal Nerve Fiber Layer In Neovascular AGE-RELATED Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Purpose: To analyze the changes in ganglion cell complex and peripapillary retinal nerve fiber layer thickness, in central macular thickness and choroidal thickness on spectral domain optical coherence tomography in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. Methods: All consecutive patients with untreated neovascular age-related macular degeneration received loading phase of three monthly intravitreal ranibizumab, followed by retreatments on a pro re nata protocol for 12 months. Primary outcome: changes in ganglion cell complex and retinal nerve fiber layer at the end of follow-up. Secondary outcome: changes in best-corrected visual acuity, central macular thickness, and choroidal ...

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    18. Analysis Of AGE-RELATED Choroidal Layers Thinning In Healthy Eyes Using SWEPT-SOURCE Optical Coherence Tomography

      Analysis Of AGE-RELATED Choroidal Layers Thinning In Healthy Eyes Using SWEPT-SOURCE Optical Coherence Tomography

      Purpose: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography. Methods: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, and no systemic or ocular diseases. Two independent investigators determined the macular horizontal choroidal thickness (CT) and the Haller's layer thickness across a 9 mm line centered at the fovea. Subjects ...

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    19. Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states. Participants were randomly allocated to 60 min of orange juice rinsing (pH 3.8) followed by 60 min of water rinsing (pH 6.7) and vice versa, with a 2-week ...

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    20. Association of Electrochemical Therapy With Optical, Mechanical, and Acoustic Impedance Properties of Porcine Skin

      Association of Electrochemical Therapy With Optical, Mechanical, and Acoustic Impedance Properties of Porcine Skin

      Importance The classic management of burn scars and other injuries to the skin has largely relied on soft-tissue transfer to resurface damaged tissue with local tissue transfer or skin graft placement. In situ generation of electrochemical reactions using needle electrodes and an application of current may be a new approach to treat scars and skin. Objective To examine the changes in optical, mechanical, and acoustic impedance properties in porcine skin after electrochemical therapy. Design, Setting, and Participants This preclinical pilot study, performed from August 1, 2015, to November 1, 2016, investigated the effects of localized pH-driven electrochemical therapy of ex ...

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    21. Optical Coherence Tomography Angiography in Dry Age-related Macular Degeneration

      Optical Coherence Tomography Angiography in Dry Age-related Macular Degeneration

      Optical coherence tomography angiography (OCT-A) is a new imaging modality that provides non-invasive characterization and quantification of the microvasculature in different retinal conditions. The purpose of this paper is to give an updated review of the features of dry age-related macular degeneration investigated by means of new generation OCT-A. We searched PubMed and Medline using the terms “optical coherence tomography angiography” associated with “age-related macular degeneration”, “drusen”, “reticular pseudodrusen,” and “geographic atrophy” and reviewed publications up to January, 2017.

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    22. Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

      Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

      Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e. 1 with 2, 2 with 3, etc) indicated differences in retinal thicknesses and ratios. Overall retinal thickness, ganglion cell layer (GCL) thickness, inner plexiform layer (IPL) thickness, and their ...

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    23. Spectral domain optical coherence tomography findings of patients under treatment for pediatric acute lymphoblastic leukemia

      Spectral domain optical coherence tomography findings of patients under treatment for pediatric acute lymphoblastic leukemia

      Purpose To investigate the use of spectral domain optical coherence tomography (SD-OCT) findings in pediatric acute lymphoblastic leukemia (ALL) patients. Methods Children that were diagnosed with precursor B-cell ALL and classified as belonging to the medium-risk group for relapse were selected for this study. Individuals who were in continuous remission and on maintenance therapy were included in the study group. Cases that had central nervous system involvement were excluded. Age-matched, otherwise healthy children were selected for the control group. Each study participant underwent a comprehensive eye examination and SD-OCT evaluation. Thickness measurements were made within the retinal nerve fiber layer ...

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    1-24 of 22016 1 2 3 4 ... 916 917 918 »
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