1. All Articles

    1-24 of 30363 1 2 3 4 ... 1264 1265 1266 »
    1. Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series

      Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series

      Alopecia areata (AA) is an autoimmune hair loss condition that is difficult to treat and frequently disruptive to the psychosocial well-being of patients. Platelet-rich plasma (PRP) is an innovative therapy that provides concentrated GFs that impart anti-inflammatory effects. Optical coherence tomography (OCT) is a noninvasive imaging modality with the potential for providing quantitative monitoring of AA response to PRP. Our objective is to share our experience using OCT to monitor the therapeutic progress of patients with AA treated with PRP. Two patients with patchy AA and one with alopecia universalis were treated with PRP three times at 6-week intervals as ...

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    2. NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY

      NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY

      PURPOSE: To precisely quantify retinal nonperfusion areas (NPAs) in branch retinal vein occlusion (BRVO) using widefield optical coherence tomography angiography (OCTA), and examine their association with neovascular complications. METHODS: We enrolled 26 patients with treatment-naïve BRVO and prospectively examined them for 12 months. After three monthly ranibizumab injections to treat macular edema, each patient underwent ultra-wide field (UWF) fluorescein angiography (FA) and OCTA. UWF FA was additionally performed at Month 12. For UWF FA, the retinal NPA was measured using the equipment’s built-in software. For OCTA, we used panoramic image montaged from 5 single 12×12 mm 2 ...

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    3. Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography

      Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography

      Purpose: To compare widefield optical coherence tomography-angiography (OCTA) to ultra-widefield fluorescein angiography (UWFA) in the assessment of nonperfusion in retinal vein occlusion (RVO). Methods: Cross-sectional study of 43 eyes of 43 RVO patients examined using both widefield OCTA (Plexelite, Carl Zeiss Meditec) with a panoramic montage of five 12x12mm images and UWFA (Optos®, 200°). Qualitative analysis was performed according to nonperfusion areas (cutoff: 3 disc areas) on widefield OCTA. The quantitative analysis assessed the vascular density (VD) on the widefield OCTA and ischemic index (ISI) on UWFA. Results: ISI on UWFA and VD in the superficial and deep plexus correlated ...

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    4. Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT

      Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT

      Abstract Purpose : To determine the location of (1) the superior–inferior watershed between the fovea and optic disc (extended raphe) at the peripapillary optical coherence tomography (OCT) measurement circle and (2) the raphe, temporal to the fovea. Methods : We used existing data consisting of 2285 traced retinal nerve fiber bundle trajectories from 83 fundus images. For localization of the extended raphe at the 3.46-mm-diameter OCT measurement circle, trajectories were classified as belonging to the superior or inferior hemiretina, using predefined criteria. For the raphe, we localized the endings of trajectories coming from the superior and inferior arcuate bundles. Results ...

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    5. Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

      Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

      Purpose : The purpose of this study was to investigate the effect of device and scan size on quantitative optical coherence tomography angiography (OCT-A) metrics. Methods : The 3 × 3 mm scans from Optovue AngioVue and Zeiss AngioPlex systems were included for 18 eyes of 18 subjects without ocular pathology. The foveal avascular zone (FAZ) was segmented manually by two observers, from which estimates of FAZ area (using both the nominal image scale and the axial length corrected image scale) and acircularity were derived. Three scan sizes (3 mm, 6 mm HD, and 8 mm) from the AngioVue system were included for ...

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    6. Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Purpose : To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods : Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thickness on OCT scans of the right eye of 10 healthy adults. Three OCT systems were used: handheld Leica Envisu, investigational handheld swept-source OCT (UC3), and Heidelberg Spectralis tabletop system. All eyes were imaged five times with each OCT system by each of two imagers. A components of variance analysis provided estimates of repeatability (variation due to random ...

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    7. Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection

      Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection

      Objectives . To evaluate the internal morphology of blebs using anterior-segment optical coherence tomography (AS-OCT) and the surgical outcomes of Ahmed glaucoma valve (AGV) surgery with Tenon capsule resection compared to conventional AGV surgery in patients with refractory glaucoma. Patients and Methods . This randomised prospective study included 30 eyes from 30 patients (age range: 42–55 y) with refractory glaucoma from March 2018 to February 2020. The study included two groups: AGV with the Tenon capsule resection group ( n  = 15) and the conventional AGV surgery group ( n  = 15). Follow-up continued until 6 months after surgery. The primary outcome was intraocular pressure ...

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    8. Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy

      Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy

      Purpose To describe a case of pregnancy-related central serous chorioretinopathy (pCSCR) and the utility of monitoring with optical coherence tomography (OCT) and OCT angiography (OCTA). Observations A 34-year-old female in her third trimester of pregnancy presented with symptomatic visual disturbances of the right eye. Medical history was otherwise unremarkable. Optical coherence tomography (OCT) disclosed a serous retinal detachment with trace subretinal fibrin and elevation of the retinal pigment epithelium (RPE). OCT angiography (OCTA) demonstrated absence of choroidal neovascular membrane (CNV). It was decided to monitor with weekly OCTs until delivery, after which the patient had full resolution of symptoms and ...

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      Mentions: UCLA
    9. Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography

      Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography

      Optical imaging for early disease diagnosis, especially cancer, has created significant interest. Label-free methods have gained attention in this regard. The light–matter interaction means that the combination of more than one optical modality for imaging can lead to enhanced specificity and sensitivity. Here we describe efforts using inelastic scattering (Raman) analysis for molecular fingerprinting of tissue combined with morphological information obtained from optical coherence tomography (OCT). This chapter focuses on innovations in these systems that allow us to co-register images at depth simultaneously for both these imaging modes and potential applications for disease diagnosis.

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    10. Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography

      To preserve the fertility of young female cancer patients, ovarian tissue cryopreservation and transplantation have been investigated as next-generation reproductive medical technologies. Non-invasive visualization of follicles in ovarian tissue and cryopreservation of higher density tissue is essential for effective transplantation. We proposed the use of optical coherence tomography (OCT) that can noninvasively visualize the internal structure of the ovarian tissue. However, a method for quantifying cell density has not yet been established because of the lack of available techniques to visualize follicles noninvasively. We proposed the use of a convolutional neural network (CNN) to extract small features from medical images ...

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    11. Diagnosis of Coronary Heart Disease by Optical Coherence Tomography Using Random Walk Algorithm

      Diagnosis of Coronary Heart Disease by Optical Coherence Tomography Using Random Walk Algorithm

      Objective : The objective is to study the diagnosis of coronary heart disease by optical coherence tomography based on random walk algorithm, so as to assist doctors in diagnosing coronary heart disease. Method : K -means algorithm combined with mathematical morphology provides seed points for random walk algorithm, and realizes semi-automatic segmentation of different kinds of patches. Secondly, by adding the space distance term based on the distance between the edge and the seed point in the weight function, the random walk algorithm is improved, which can make the weak edge patch area not be segmented too much. Results : the results were ...

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    12. Optical coherence tomography angiography findings in patients with ocular and non-ocular Behcet disease

      Optical coherence tomography angiography findings  in patients with ocular and non-ocular Behcet disease

      Purpose: To describe the optical coherence tomography angiography findings in nonocular Behçet disease . Methods: The superficial capillary plexus (SCP) and deep capillary plexus (DCP) and outer retinal and choroidal flow were evaluated using optical coherence tomography angiography . Perimetry was performed to correlate any microvascular and functional changes. Results: Capillary nonperfusion areas were found in the superficial capillary plexus in 16/20 eyes (80%) and in the DCP in 17/20 eyes (85%). Perifoveal capillary arcade disruption and vessel rarefaction were present in both plexuses in all cases. Capillary telangiectasia was present in the superficial capillary plexus in five eyes ...

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    13. Use of computerized campimetry and/or optical coherence tomography for glaucoma diagnosis by non-glaucoma specialists

      Use of computerized campimetry and/or optical coherence tomography for glaucoma diagnosis  by non-glaucoma specialists

      PURPOSE: To compare the use of visual field and/or optical coherence tomography (OCT) combined with color retinography by non-glaucoma specialists for differentiating glaucoma from physiological cupping. METHODS: Eighty patients with glaucoma or physiological cupping (40 of each) were randomized according to the examination used (GI: color retinography, GII: color retinography + visual field, GIII: color retinography + optical coherence tomography, GIV: color retinography + visual field + optical coherence tomography). Twenty non-specialist ophthalmologists diagnosed glaucoma from PowerPoint slide images, without direct patient examination. RESULTS: Inter-examiner agreement was good for GII (ĸ: 0.63; 95%CI, 0.53-0.72), moderate for GIII (ĸ: 0 ...

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    14. Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction

      Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction

      Purpose of Review To review evidence on the utility of spectral domain optical coherence tomography (SD-OCT) in evaluating retinal structure prior cataract surgery and highlight new technologies that can assess retinal function perioperatively. Recent Findings SD-OCT detected clinically unsuspected macular pathology in 4.6–25% of individuals in the pre-operative cataract evaluation. The most common findings were epiretinal membrane and macular degeneration with frequencies that varied by population studied. These conditions have been associated with complication after surgery (e.g., macular edema, visual dissatisfaction). As such, findings on SD-OCT may impact the informed consent process, alter IOL selection, and provide ...

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    15. Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Significance: The optical properties of biological samples provide information about the structural characteristics of the tissue and any changes arising from pathological conditions. Optical coherence tomography (OCT) has proven to be capable of extracting tissue's optical properties using a model that combines the exponential decay due to tissue scattering and the axial point spread function that arises from the confocal nature of the detection system, particularly for higher numerical aperture (NA) measurements. A weakness in estimating the optical properties is the inter-parameter cross-talk between tissue scattering and the confocal parameters defined by the Rayleigh range and the focus depth ...

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    16. Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

      Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

      Purpose: To study the subfoveal choroidal thickness (SFCT), macular ganglion cell layer (GCL-IPL) and central macular thickness (CMT) in Caucasian children, and to analyze these optical coherence tomography (OCT) parameters depending on the spherical equivalent (SE). Methods: Cross-sectional study of SFCT, GCL-IPL, and CMT in Caucasian children, analyzed with spectral-domain OCT Cirrus 5000 and Enhanced-depth imaging technique. Correlation between these three OCT parameters, age, sex, and spherical equivalent was analyzed. The eyes were classified into three groups: group 1 included eyes with SE < 0, group 2 included eyes with SE between 0 and +2.00, and group 3 eyes with ...

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    17. Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma

      Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma

      Purpose: The aim of this study was to investigate the changes in vessel density (VD) in glaucoma patients and to investigate the relationship between VD and structural parameters using optical coherence tomography angiography. Methods: Our study included 25 primary open-angle glaucoma (POAG) patients, 25 pseudoexfoliation glaucoma (PXG) patients and 25 healthy individuals. All patients underwent 6 × 6 mm retinal angiography (upper limit: internal limitan membrane [ILM], lower limit: 10 µm inferior to inner plexiform layer) and 4.5 × 4.5 mm disk angiography (upper limit: ILM, lower limit: posterior border of the retinal nerve fiber layer [RNFL]) via an optical ...

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      Mentions: Optovue
    18. 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility

      3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility

      The three-dimensional (3D) representation of the bifurcation anatomy and disease burden is essential for better understanding of the anatomical complexity of bifurcation disease and planning of stenting strategies. We propose a novel methodology for 3D reconstruction of coronary artery bifurcations based on the integration of angiography, which provides the backbone of the bifurcation, with optical coherence tomography (OCT), which provides the vessel shape. Our methodology introduces several technical novelties to tackle the OCT frame misalignment, correct positioning of the OCT frames at the carina, lumen surface reconstruction, and merging of bifurcation lumens. The accuracy and reproducibility of the methodology were ...

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    19. Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT

      Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT

      Abstract Purpose: To assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device. Methods: This prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images of the anterior segment were obtained using a new swept-source AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking and image averaging from the right eye of all participants. Repeatability as well as inter- and intra-observer reliability of biometric measurements were evaluated. The impact of image tracking and averaging on ciliary muscle measurements was ...

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    20. The evaluation of juvenile ocular hypertension by optical coherence tomography angiography

      The evaluation of juvenile ocular hypertension by optical coherence tomography angiography

      Background Vessel density (VD) of the elderly ocular hypertension patients measured by optical coherence tomography angiography (OCTA) have been reported. However, the studies of VD in juvenile ocular hypertension (JOHT) are limited. We wished to evaluate VD changes using OCTA in JOHT. We also investigated the potential risk parameters of intraocular pressure (IOP) and vertical cup/disc ratio (CDR) with OCTA for observing the development of JOHT. Methods We examined 86 eyes in 45 control (Ctrl) subjects and 65 eyes in 34 patients with JOHT using OCTA at the glaucoma clinic of the Eye, Ear, Nose, and Throat Hospital of ...

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      Mentions: Fudan University
    21. Superficial capillary perfusion on optical coherence tomography angiography differentiates moderate and severe nonproliferative diabetic retinopathy

      Superficial capillary perfusion on optical coherence tomography angiography differentiates moderate and severe nonproliferative diabetic retinopathy

      Purpose To identify objective optical coherence tomography angiography (OCTA) parameters that characterize the spectrum of non-proliferative diabetic retinopathy (NPDR), especially those that distinguish moderate from severe NPDR. Methods Sixty eyes of 60 patients with treatment-naïve NPDR (mild: 21, moderate: 21, severe: 18), 23 eyes with diabetes and no retinopathy, and 24 healthy control eyes were enrolled. OCTA slabs were segmented into superficial (SCP), middle (MCP), and deep capillary plexus (DCP) and thresholded by a new method based on DCP skeletonized vessel length. The foveal avascular zone (FAZ) area, parafoveal vessel density (VD), and adjusted flow index (AFI) from all ...

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    22. Autologous neurosensory free-flap retinal transplantation for refractory chronic macular hole—outcomes evaluated by OCT, microperimetry, and multifocal electroretinography

      Autologous neurosensory free-flap retinal transplantation for refractory chronic macular hole—outcomes evaluated by OCT, microperimetry, and multifocal electroretinography

      Purpose To report the safety, anatomical and functional outcomes of autologous neurosensory retinal transplant in patients with a refractory large unclosed macular hole. Patients and methods This is a prospective case series of four patients with large chronic macular hole that underwent vitrectomy and free-flap neurosensory retinal transplantation surgery with silicone oil tamponade. The hole was closed with an autologous retinal transplant of an approximate diameter of 1.5–1.8 mm, harvested outside the vascular arcades. Anatomical and functional outcomes were assessed using best-corrected visual acuity (BCVA-Snellen), optical coherence tomography (OCT), OCT angiography, microperimetry (MP), and multifocal electroretinography (mfERG ...

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    23. Magnetic resonance imaging and optical coherence tomography correlations in multiple sclerosis beyond anatomical landmarks

      Magnetic resonance imaging and optical coherence tomography correlations in multiple sclerosis beyond anatomical landmarks

      Objective: To investigate multiple sclerosis (MS) optical coherence tomography (OCT) cross-sectional correlations with central nervous system (CNS) magnetic resonance imaging (MRI). Material and methods: Peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner (INL) and outer nuclear layer (ONL) of 54 relapsing remitting (RRMS) and 38 progressive (PMS, 9 primary and 29 secondary) patients were measured. With less than 3 months brain parenchymal fraction (BPF), spinal cord (SC), total gray matter (GM) and white matter volumes were calculated. Demographical and clinical data was compared according to the history of optic neuritis (HON). Relationships between ...

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