1. All Articles

    1-24 of 15634 1 2 3 4 ... 650 651 652 »
    1. Evaluation of IVOCT imaging of coronary artery metallic stents with neointimal coverage

      Evaluation of IVOCT imaging of coronary artery metallic stents with neointimal coverage

      Accuracy of IVOCT for measurement of neointimal thickness and effect of neointima in the appearance of metallic struts in IVOCT images was investigated. Phantom vessels were constructed and coronary stents were deployed and covered with thick (250–400 μm) and thin (30–70 μm) phantom neointima. High resolution Micro-CT images of the stent struts were recorded as a gold standard. IVOCT images of the phantom vessels were acquired with various luminal blood scattering strengths and measured neointimal thicknesses from IVOCT and Micro-CT images were compared. In transparent lumen, comparison of IVOCT and Micro-CT neointima thickness measurements found no significant difference ...

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    2. Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma

      Diagnostic accuracy of the parameters from ganglion cell  complex map, evaluated with SD-OCT in primary open-angle  glaucoma

      Purpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their role in diagnosis of primary open-angle glaucoma patients. Materials and methods: The study included 84 eyes of patients with primary open-angle glaucoma (POAG) and 40 eyes of healthy individuals. All of them underwent complete eye examination, including standard automated perimetry (HFA II) and OCT (RTVue-100). Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (globаl loss volume), FLV (focal loss volume) and RNFL (retinal nerve fiber layer — ONH map) were measured. ROC curves ...

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    3. Scaffold and Edge Vascular Response Following Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffold : A 3-Year Serial Optical Coherence Tomography Study

      Scaffold and Edge Vascular Response Following Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffold : A 3-Year Serial Optical Coherence Tomography Study

      Objectives This study sought to investigate the in-scaffold vascular response (SVR) and edge vascular response (EVR) after implantation of an everolimus-eluting bioresorbable scaffold (BRS) using serial optical coherence tomography (OCT) imaging. Background Although studies using intravascular ultrasound have evaluated the EVR in metal stents and BRSs, there is a lack of OCT-based SVR and EVR assessment after BRS implantation. Methods In the ABSORB Cohort B (ABSORB Clinical Investigation, Cohort B) study, 23 patients (23 lesions) in Cohort B1 and 17 patients (18 lesions) in Cohort B2 underwent truly serial OCT examinations at 3 different time points (Cohort B1: post-procedure, 6 ...

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    4. Recanalized Thrombus Treated With Bioresorbable Vascular Scaffold Insights From Optical Coherence Tomography

      Recanalized Thrombus Treated With Bioresorbable Vascular Scaffold Insights From Optical Coherence Tomography

      A 29-year-old man underwent coronary angiography after non–ST-segment elevation myocardial infarction. He was a current smoker and did not have any other relevant medical history. Coronary angiography revealed a lesion with contrast filling defect and irregular lumen border at the mid-segment of the left anterior descending artery (Figure 1 ). Coronary distal flow was partially preserved. Optical coherence tomography (OCT) was performed to characterize the lesion. Lesion was crossed with a BMW Coronary guidewire (Abbott Vascular, Abbott Park, Illinois) and placed in the distal left anterior descending artery. An OCT catheter (C7-XR, Dragon Fly, LightLab, St. Jude Medical, St. Paul ...

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    5. Leading Irish University Bio-Photonics Laboratory And Compact Imaging Extend Agreement For Innovative Research Collaboration

      Leading Irish University Bio-Photonics Laboratory And Compact Imaging Extend Agreement For Innovative Research Collaboration

      NUI Galway’s TOMI Lab Provides Globally-Recognized Scientific Leadership for Advanced Development of Company’s Mobile OCT Technology The National University of Ireland Galway (NUI Galway) ( www.nuigalway.com.ie ) and Compact Imaging, Inc. (CI) ( www.compactimaging.com ) today jointly announced the extension of their innovative research collaboration in the field of optical coherence tomography (OCT) for a variety of applications, including mobile health monitoring and identity verification. The research agreement will continue the advanced development of CI’s novel multiple reference OCT sensor technology, MRO™, very small, low cost, low operating power OCT architecture ideal for high volume mobile ...

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    6. Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill

      Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill

      The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill seeks a highly motivated Postdoc to perform research in ultrahigh-resolution optical coherence tomography (UHR-OCT). Research activities will involve optical system construction and data acquisition hardware and software. They will also involve biological studies of cells and tissues primarily related to our lab's ongoing efforts in Marine Biology. Candidates with a strong background in optics and data acquisition are particularly sought, but should also demonstrate a genuine interest in biological and biomedical science. A demonstrated record of publication in peer-reviewed journals is required to be competitive for ...

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    7. In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography

      In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography

      No published reports have demonstrated the capability of the optical coherence tomography technique for quantifying the optical coherence tomography signal slope, 1/e light penetration depth, and attenuation coefficient of hyperglycemic blood by an in vitro assessment. The purpose of this study was to investigate the effects of hyperglycemia on optical properties during in vitro blood coagulation by optical coherence tomography. Normal whole blood acted as the control group. After 1-h coagulation, the average optical coherence tomography signal slope decreased approximately 23.3 and 16.7 %, and the 1/e light penetration depths increased approximately 21.5 and 19.2 ...

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    8. Intraocular optical coherence tomography

      Intraocular optical coherence tomography

      Since its introduction as a diagnostic instrument, optical coherence tomography (OCT) has become an essential instrument for ophthalmologists as it offers accurate details on both the vitreoretinal interface and the retinal layers. Initially designed as a pre- and post-operative instrument, today we are attending to its introduction as an intraoperative tool. Inspired by the intravascular use of the OCT, we developed a prototype spectral domain OCT probe for intraocular use. It is therefore possible to make dynamic real-time scans from the vitreous and retina at the posterior pole and in the peripheral retina. This type of endo-OCT may therefore help ...

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    9. Depth-encoded all-fiber swept source polarization sensitive OCT

      Depth-encoded all-fiber swept source polarization sensitive OCT

      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We ...

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    10. Endoscopic imaging in Barrett's esophagus

      Endoscopic imaging in Barrett's esophagus

      Barrett’s esophagus is the only known precursor that predisposes patients to the development of esophageal adenocarcinoma. The current recommended surveillance method is targeted biopsies of any abnormalities followed by random four-quadrant biopsies every 2 cm using standard white light endoscopy. Compliance with this and sampling error are two of the biggest problems. Several novel imaging technologies have been developed to aid the diagnosis of early neoplasia in Barrett’s esophagus. There are emerging data that some of these new modalities can increase the yield of detecting dysplasia. This review will discuss some of the present available techniques and technologies ...

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    11. Application of Improved Homogeneity Similarity-Based Denoising in Optical Coherence Tomography Retinal Images

      Application of Improved Homogeneity Similarity-Based Denoising in Optical Coherence Tomography Retinal Images

      Image denoising is a fundamental preprocessing step of image processing in many applications developed for optical coherence tomography (OCT) retinal imaging—a high-resolution modality for evaluating disease in the eye. To make a homogeneity similarity-based image denoising method more suitable for OCT image removal, we improve it by considering the noise and retinal characteristics of OCT images in two respects: (1) median filtering preprocessing is used to make the noise distribution of OCT images more suitable for patch-based methods; (2) a rectangle neighborhood and region restriction are adopted to accommodate the horizontal stretching of retinal structures when observed in OCT ...

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    12. Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

      Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

      Purpose The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA). Methods The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field. Results The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8 %), followed by the inferior (35.5 %), superior (27.2 %), and nasal quadrants ...

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    13. Optical coherence elastography for tissue characterization: a review

      Optical coherence elastography for tissue characterization: a review

      Optical coherence elastography (OCE) represents the frontier of optical elasticity imaging techniques and focuses on the micro-scale assessment of tissue biomechanics in 3D that is hard to achieve with traditional elastographic methods. Benefit from the advancement of optical coherence tomography, and driven by the increasing requirements in nondestructive biomechanical characterization, this emerging technique recently has experienced a rapid development. In this paper, we start with the description of the mechanical contrast that has been employed by OCE and review the state-of-the-art techniques based on the reported applications and discuss the current technical challenges, emphasizing the unique role of OCE in ...

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    14. Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study

      Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study

      Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and ...

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    15. Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Purpose To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients. Methods In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several epithelium statistics for each eye, including central, superior, inferior, minimum, maximum, minimum − maximum, and map standard deviation, were averaged. Correlations of epithelial thickness with the symptoms of dry eye were calculated. Results The mean ...

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    16. Monte Carlo modeling of angiographic optical coherence tomography

      Monte Carlo modeling of angiographic optical coherence tomography

      Optical coherence tomography (OCT) provides both structural and angiographic imaging modes. Because of its unique capabilities, OCT-based angiography has been increasingly adopted into small animal and human subject imaging. To support the development of the signal and image processing algorithms on which OCT-based angiography depends, we describe here a Monte Carlo-based model of the imaging approach. The model supports arbitrary three-dimensional vascular network geometries and incorporates methods to simulate OCT signal temporal decorrelation. With this model, it will be easier to compare the performance of existing and new angiographic signal processing algorithms, and to quantify the accuracy of vascular segmentation ...

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    17. Suboptimal stent deployment is associated with subacute stent thrombosis: Optical Coherence Tomography insights from a multicenter matched study. From the CLI Foundation investigators: the CLI-THRO study

      Suboptimal stent deployment is associated with subacute stent thrombosis: Optical Coherence Tomography insights from a multicenter matched study. From the CLI Foundation investigators: the CLI-THRO study

      Background Acute or sub-acute stent thrombosis (ST) is a well described complication usually causing acute coronary syndromes (ACS) and in the worst case scenario sudden cardiac death. In this study we aimed at exploring the potential role of optical coherence tomography (OCT) in the understanding of the mechanism of ST. Methods Twenty-one consecutive patients, after ACS due to a definite sub-acute ST, were assessed with OCT and matched 1:2 with 42 patients undergoing OCT for scheduled follow-up. OCT assessment was focused on features indicative of non-optimal stent deployment: under-expansion, malapposition, edge dissection and reference lumen narrowing. Results OCT revealed ...

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    18. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries ...

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    19. UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      Bigio’s team isn’t the only one to encounter this difficulty in attracting funding. Dr. Adam Wax’s group at Duke University has been developing a technique – angle-resolved low-coherence interferometry, or a/LCI – enabling early detection of cancer and other biomedical applications by measuring the average size of cell nuclei using scattered light. The focus of the a/LCI instrument has been Barrett’s esophagus, a precursor to esophageal cancer. But Wax is also looking beyond the upper GI tract. In his research lab at Duke, he and colleagues have been working to develop the technology further, to bring ...

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    20. Optical coherence tomography for an in-vivo study of posterior-capsule-opacification types and their influence on the total-pulse energy required for Nd:YAG Capsulotomy: a case series

      Optical coherence tomography for an in-vivo study of posterior-capsule-opacification types and their influence on the total-pulse energy required for Nd:YAG Capsulotomy: a case series

      Background Posterior capsule opacification (PCO) is the most common post-operative complication associated with cataract surgery and is mostly treated with Nd:YAG laser capsulotomy. Here, we demonstrate the use of high-resolution spectral-domain optical coherence tomography (OCT) as a technique for PCO analysis. Additionally, we evaluate the influence of PCO types and the distance between the intraocular lens (IOL) and the posterior capsule (PC), i.e., the IOL/PC distance, on the total-pulse energy required for the Nd:YAG laser posterior capsulotomy. Methods 47 eyes with PCO scheduled for the Nd:YAG procedure were examined and divided into four categories: fibrosis ...

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    21. Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Purpose To determine the repeatability, reproducibility, and agreement of anterior chamber depth (ACD) measurements obtained with 3 Scheimpflug cameras and an anterior segment optical coherence tomography (AS-OCT) device. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Observational cross-sectional study. Methods Two observers took 3 consecutive measurements in healthy right eyes using each device to assess intraoperator repeatability. The mean values obtained at different sessions by the first operator were used to determine the intersession reproducibility. Three consecutive measurements obtained by the first operator at the first session were averaged and used to assess agreement. Results The ACD measurements ...

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    22. Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

      Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

      The maintenance of urinary bladder elasticity is essential to its functions, including the storage and voiding phases of the micturition cycle. The bladder stiffness can be changed by various pathophysiological conditions. Quantitative measurement of bladder elasticity is an essential step toward understanding various urinary bladder disease processes and improving patient care. As a nondestructive, and noncontact method, laser-induced surface acoustic waves (SAWs) can accurately characterize the elastic properties of different layers of organs such as the urinary bladder. This initial investigation evaluates the feasibility of a noncontact, all-optical method of generating and measuring the elasticity of the urinary bladder. Quantitative ...

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    23. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

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    1-24 of 15634 1 2 3 4 ... 650 651 652 »
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