1. All Articles

    1-24 of 25651 1 2 3 4 ... 1067 1068 1069 »
    1. High-Quality Imaging Brings Vision to Researchers and Patients

      High-Quality Imaging Brings Vision to Researchers and Patients

      The Beginning Macular degeneration is a disease that afflicts 11 million patients in the United States and is estimated to cost the global economy more than $300B annually. The first generation of Optical Coherence Tomography (OCT) was introduced to visualize retinal pathology and was finding a role in the monitoring treatments for age-related macular degeneration (AMD). This first-generation imaging technology suffered from low resolution and low speed. Joseph Izatt, Bioptigen’s scientific co-founder, recognized the value in a new implementation of OCT—Spectral Domain OCT—that operated up to 1000 times faster and had the potential for visualizing structures of ...

      Read Full Article
    2. Optical Coherence Tomography Angiography Evolution of Choroidal Neovascular Membrane in Choroidal Rupture Managed by Intravitreal Bevacizumab

      Optical Coherence Tomography Angiography Evolution of Choroidal Neovascular Membrane in Choroidal Rupture Managed by Intravitreal Bevacizumab

      Purpose . To describe a case of a 25-year-old man with choroidal neovascularization (CNV) secondary to traumatic choroidal rupture treated with intravitreal bevacizumab and to evaluate the vascular structure of the area near the traumatic choroidal rupture. Methods . The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity (BCVA), intraocular pressure, anterior segment and funds examination, and optical coherence tomography angiography (OCTA) at baseline and on each follow-up visit. Fluorescein angiography (FA) was performed at baseline. Intravitreal bevacizumab was administered at the time of choroidal neovascular membrane diagnosis. Results . At baseline, ophthalmoscopic examination of the left eye revealed four subretinal macular ...

      Read Full Article
    3. Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography

      Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography

      Investigation of tumor development is essential in cancer research. In the laboratory, living cell culture is a standard bio-technology for studying cellular response under tested conditions to predict in vivo cellular response. In particular, the colony formation assay has become a standard experiment for characterizing the tumor development in vitro. However, quantification of the growth of cell colonies under a microscope is difficult because they are suspended in a three-dimensional environment. Thus, optical coherence tomography (OCT) imaging was develop in this study to monitor the growth of cell colonies. Cancer cell line of Huh 7 was used and the cells ...

      Read Full Article
    4. Macular colobomata: Comparison of clinical and optical coherence tomography features with serological result

      Macular colobomata: Comparison of clinical and optical coherence tomography features with serological result

      Purpose To assess the correlation between the morphological features and serology in eyes with macular colobomata (MC). Design Retrospective comparative case series Methods Setting: Institutional Study population Patients presenting with MC to the retina clinic over a period of two years (January 2016 to December 2017) Interventional/Observational procedure: Color fundus and swept source optical coherence tomography (SS-OCT, Topcon Inc.) features were reviewed and assessed in three groups based on the serum IgG results: positive for Toxoplasma, positive for Cytomegalovirus (CMV), and serology negative. Main outcome measure Morphological features on clinical and OCT-based examination Results A total of 49 eyes ...

      Read Full Article
    5. Miniature all-fiber axicon probe with extended Bessel focus for optical coherence tomography

      Miniature all-fiber axicon probe with extended Bessel focus for optical coherence tomography

      The trade-off between lateral resolution and depth of focus (DOF) severely limits the capability of endoscopic optical coherence tomography (OCT) for high-resolution deep-tissue imaging. To address this issue, we developed a novel miniature all-fiber axicon OCT probe by inserting a segment of gradient-index (GRIN) fiber between a piece of single-mode fiber (SMF) and an axicon polished from a no-core fiber. The GRIN lens served as a beam expander extending the probe DOF by 5.2 times while maintaining a high lateral resolution of 2 μm. The DOF extension was experimentally verified by measuring the axial profile of the probe output ...

      Read Full Article
      Mentions: Wei Wang
    6. Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography

      Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography

      Biological functions rely on local microvasculature to deliver oxygen and nutrients and carry away metabolic waste. Alterations to local oxygenation levels are manifested in diseases including cancer, diabetes mellitus, etc. The ability to quantify oxygen saturation (sO 2 ) within microvasculature in vivo to assess local tissue oxygenation and metabolic function is highly sought after. Visible light optical coherence tomography (vis-OCT) angiography has shown promise in reaching this goal. However, achieving reliable measurements in small vessels can be challenging due to the reduced contrast and requires data averaging to improve the spectral data quality. Therefore, a method for quality-control of the ...

      Read Full Article
    7. Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy

      Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy

      Purpose To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC). Methods This prospective study included 48 eyes of 41 patients with chronic CSC. Enhanced depth imaging optical coherence tomography and optical coherence tomography angiography (OCTA) images were analyzed. Choroidal area (CA), luminal area (LA), and stromal area (SA) were computed using Image J software. Results One month after hf-PDT, total CA decreased to 1.312 mm 2 from 1.490 mm 2 ( p  < 0.001), LA decreased to 0.981 mm 2 from 1.097 ...

      Read Full Article
    8. Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

      Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

      Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology. OCT and its recent variant, dynamic OCT, permit rapid noninvasive depth-resolved imaging of the capillaries in the superficial dermis via a handheld probe ...

      Read Full Article
    9. Comparison of retinal nerve fiber layer thickness between normal population and patients with diabetes mellitus using optical coherence tomography

      Comparison of retinal nerve fiber layer thickness between normal population and patients with diabetes mellitus using optical coherence tomography

      Objective: To compare the difference in peripapillary Retinal Nerve Fibre Layer (RNFL) thickness between normal population and Type-II diabetic patients without diabetic retinopathy using Spectral Domain Optical Coherence Tomography (SD OCT). Methods: This cross sectional study was carried out at PNS Shifa Naval Hospital, from May 2017 to November 2017. Out of 200 eyes, 100 eyes were of normal individuals and 100 eyes were of Type-II diabetic patients without diabetic retinopathy. Both groups were age and gender matched. Average RNFL thickness, along with RNFL of each quadrant of individuals was noted using SD OCT, and compared between two groups. Results ...

      Read Full Article
    10. Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease

      Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease

      Purpose Automated spectral domain optical coherence tomography (SD-OCT) segmentation algorithms currently do not perform well in segmenting individual intraretinal layers in eyes with Stargardt disease (STGD). We compared selective B-scan segmentation strategies for generating mean retinal layer thickness and preserved area data from SD-OCT scans in patients with STGD1. Methods Forty-five eyes from 40 Stargardt patients were randomly selected from the ongoing Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) study. All eyes underwent SD-OCT using a standard macular volume consisting of 1024 × 49 equally spaced B-scans within a 20 × 20 degree field centered on the ...

      Read Full Article
    11. Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment

      Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment

      Purpose To detect pre- and postoperative retinal changes in fundus autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) and to correlate these with functional outcome in patients with primary rhegmatogenous retinal detachment (RRD). Methods A prospective, 30-month study of patients operated with 25-gauge vitrectomy for primary RRD. Patients were examined preoperatively and after 6 and 30 months, using ultrawide-field AF images (UWFI) (Optos 200Tx) and SD-OCT (Topcon 3D OCT-2000) imaging. Results Of 84 patients (84 eyes) included at baseline, 100.0 and 86.9% were re-examined at month 6 and 30, respectively. Preoperative findings such as macular attachment, detachment ...

      Read Full Article
    12. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barrett’s epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barrett’s tissue challenge BET measurements and the study of relationships between thickness and RFA outcomes. We aimed to quantify BET and compared the reliability of standard and contrast-enhanced VLE images. Methods Baseline VLE scans from BE ...

      Read Full Article
    13. Anterior segment optical coherence tomography and its clinical applications: a review

      Anterior segment optical coherence tomography and its clinical applications: a review

      Anterior segment optical coherence tomography (AS‐OCT) has become one of the cornerstones of non‐contact imaging modalities for assessing such structures as the cornea, anterior chamber angle, aqueous outflow pathway, sclera, and ocular surface structures. As such, it has a broad range of clinical applications, which have been independently reported in the literature. This paper aims to present a review of extant literature on the utility of AS‐OCT and its efficacy in clinical applications, and to evaluate the quality of available evidence. The following databases were searched from inception to 24 June 2018: Medline via Ovid, Cochrane Central ...

      Read Full Article
    14. Full Range Swept-Source Optical Coherence Tomography with Ultra Small Fiber Probes for Biomedical Imaging (Book Chapter)

      Full Range Swept-Source Optical Coherence Tomography with Ultra Small Fiber Probes for Biomedical Imaging (Book Chapter)

      Biomedical imaging is becoming an indispensable branch within bioengineering. This research field has recently expanded due to the requirement of high-level medical diagnostics and rapid development of interdisciplinary modern technologies. This book is designed to present the most recent advances in instrumentation, methods, and image processing as well as clinical applications in important areas of biomedical imaging. It provides broad coverage of the field of biomedical imaging, with particular attention to an engineering viewpoint. The goal of the book is to provide a wide-ranging forum in the biomedical imaging field that integrates interdisciplinary research and development of interest to scientists ...

      Read Full Article
    15. A case of severely calcified neoatherosclerosis-embedded stent struts clearly documented with optical coherence tomography imaging

      A case of severely calcified neoatherosclerosis-embedded stent struts clearly documented with optical coherence tomography imaging

      A 65-year-old Japanese man using peritoneal hemodialysis due to diabetic nephropathy underwent a planned coronary angiography as a preoperative examination. Fourteen years earlier, he had undergone a percutaneous coronary intervention due to acute myocardial infarction and had been implanted with a bare-metal stent in the left anterior descending coronary artery. Although his condition had run a benign course without any recurrence of cardiovascular events, coronary angiography was performed 14 years later in preparation for a living-donor kidney transplantation. Coronary angiography revealed less than 50% restenosis (Figure A). Although Figure B indicates circumferentially covered stent struts, the homogeneous neointima pattern observed ...

      Read Full Article
    16. Extended Coherence Length and Depth Ranging Using a Fourier-Domain Mode-Locked Frequency Comb and Circular Interferometric Ranging

      Extended Coherence Length and Depth Ranging Using a Fourier-Domain Mode-Locked Frequency Comb and Circular Interferometric Ranging

      Fourier-domain mode locking has been a popular laser design for high-speed optical-frequency-domain imaging (OFDI), but achieving long coherence lengths, and therefore imaging range, has been challenging. The narrow linewidth of a Fourier-domain mode-locked (FDML) frequency-comb (FC) laser could provide an attractive platform for high-speed as well as long-range OFDI. Unfortunately, aliasing artifacts arising from signals beyond the principal measurement depth of the free spectral range have prohibited the use of an FDML FC laser for imaging so far. To make the increased coherence length of an FDML FC laser available, methods to manage such artifacts are required. Recently, coherent circular ...

      Read Full Article
    17. Updates on PCI Guidelines and Trials From the European Society of Cardiology (ESC) Congress

      Updates on PCI Guidelines and Trials From the European Society of Cardiology (ESC) Congress

      Radial Access and Provisional T-Stenting Preferred for PCI: Another important procedural recommendation from the ESC was that radial access should be the preferred approach for coronary angiography and PCI (class I recommendation). While this approach has been a standard for many years in the European communities, it has now been codified as part of the ESC guidelines and may one day be part of the ACC/SCAI guidelines. For those addressing bifurcations with stenting, the ESC/EACTS guidelines upgraded provisional T-stenting for bifurcation lesions from class IIa to class I, and upgraded the use of optical coherence tomography (OCT) for ...

      Read Full Article
    18. Optical Coherence Tomography Angiography Study for Evaluation of Microvascular Changes in the Subclinical Diabetic Retinopathy

      Optical Coherence Tomography Angiography Study for Evaluation of Microvascular Changes in the Subclinical Diabetic Retinopathy

      Background: diabetic retinopathy is the specific microvascular complication of diabetes mellitus and affects 1 of 3 with DM. DR remains a leading cause of vision loss in working adult population. Patients with severe levels of DR were reported to have poor quality of life and reduced physical, emotional and social well-being, and they utilize more health care resources. Objective: this study aimed to evaluate the vascular density, perfusion density and foveal avascular parameters changes in subjects with diabetes mellitus showing no manifestations of diabetic retinopathy using optical coherence tomography angiography. Methods: 40 subjects were categorized into two groups, group A ...

      Read Full Article
    19. ASYMPTOMATIC MULTIFOCAL PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH JUVENILE DERMATOMYOSITIS OPTICAL COHERENCE ANGIOGRAPHY FINDINGS

      ASYMPTOMATIC MULTIFOCAL PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH JUVENILE DERMATOMYOSITIS OPTICAL COHERENCE ANGIOGRAPHY FINDINGS

      Purpose: To describe a unique presentation of multifocal paracentral acute middle maculopathy in a young patient with juvenile dermatomyositis including optical coherence tomography angiography findings. Methods: Retrospective single case report. Patient: Seventeen-year-old male patient with a history of juvenile dermatomyositis presented for routine hydroxychloroquine screening. Results: Optical coherence tomography revealed undulations of the outer retinal layers and retinal thinning near the fovea in both eyes. Optical coherence tomography angiography revealed loss of flow void densities in the superficial and deep capillary plexi in both eyes. These findings were consistent with a diagnosis of paracentral acute middle maculopathy . Conclusion: To the ...

      Read Full Article
    20. New method to study biomechanical changes in tissues after laser surgery

      New method to study biomechanical changes in tissues after laser surgery

      Although currently laser surgery is a very popular tool for various vision disorders correction, it is still difficult to ensure proper control over the accuracy, efficiency and safety of such procedures. Therefore, Russian scientists proposed a new method that helps to describe tissue changes after such operations. This method was described in a series of publications in the Journal of Biophotonics , Journal of Biomedical Optics and Laser Physics Letters . For the widespread and safe clinical use of lasers for eye surgeries, it is crucial to ensure high-precision control of the given shape of the fabric and its stability. At the ...

      Read Full Article
    21. Santec Announce a Record Wavelength Scan for an Electrically Pumped VCSEL

      Santec Announce a Record Wavelength Scan for an Electrically Pumped VCSEL

      Santec Corporation (JASDAQ: 6777) Santec, a leading manufacturer of tunable lasers, optical instruments, and fiber-optic components, announces a record 88nm wide continuous wavelength scan for an electrically pumped VCSEL (Vertical Cavity Surface Emitting Laser) light source. This performance record for a 1050nm centered VCSEL is a result of a collaborative effort between Santec, Tokyo Institute of Technology and Tokyo University’s Institute of Industrial Science. This result will be reported at the upcoming Photonics West 2019 meeting in San Francisco [1]. The High-speed Scanning Tunable VCSEL’s element is made up of two parts; the VCSEL, responsible for laser oscillation ...

      Read Full Article
    22. Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography

      Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography

      A 65-year-old man underwent balloon angioplasty and repeat carotid artery stenting (CAS) due to in-stent restenosis (ISR). Intravascular optical coherence tomography (OCT) showed a severe ISR with fibrotic neointimal growth ( figure 1 ). Post 6.0 × 30 mm balloon angioplasty, OCT showed intimal disruption and artery dissection ( figure 2 ). After the 8 × 40 mm stent fully expanded, OCT showed stent struts well apposed, but tissue protrusion from the spaces between stent struts can be observed ( figure 2 ). OCT allowed measurement of intimal hyperplasia after the CAS and observation of intimal disruption and stent strut apposition intraoperatively. 1 , 2

      Read Full Article
    23. Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography

      Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography

      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX ® Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle (C 1 ), 1 ...

      Read Full Article
    1-24 of 25651 1 2 3 4 ... 1067 1068 1069 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Optical Coherence Tomography News

    See all Optical Coherence Tomography News articles
  4. Organizations in the News

    1. (807 articles) Harvard University
    2. (660 articles) Massachusetts General Hospital
    3. (651 articles) National Institutes of Health
    4. (584 articles) Massachusetts Institute of Technology
    5. (496 articles) Duke University
    6. (433 articles) Medical University of Vienna
    7. (420 articles) University of Miami
    8. (396 articles) Johns Hopkins University
    9. (392 articles) Oregon Health & Science University
    10. (378 articles) FDA
  5. People in the News

    1. (405 articles) James G. Fujimoto
    2. (325 articles) David Huang
    3. (283 articles) Ruikang K. Wang
    4. (273 articles) Joseph A. Izatt
    5. (235 articles) Guillermo J. Tearney
    6. (226 articles) Adrian G. Podoleanu
    7. (224 articles) Stephen A. Boppart
    8. (216 articles) Zhongping Chen
    9. (203 articles) Brett E. Bouma
    10. (191 articles) Patrick W. Serruys
  6. OCT Companies in the News

    1. (1645 articles) Carl Zeiss Meditec
    2. (802 articles) St. Jude Medical
    3. (665 articles) Heidelberg Engineering
    4. (664 articles) Optovue
    5. (455 articles) Topcon Medical Systems
    6. (334 articles) Volcano Corporation
    7. (259 articles) Michelson Diagnostics
    8. (237 articles) Thorlabs
    9. (229 articles) Bioptigen
    10. (160 articles) Axsun Technologies