1. All Articles

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    1. Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      The bare-metal Tryton Side Branch (SB) Stent™ (Tryton Medical, Durham, NC, USA) is used with a drug-eluting stent (DES) in the main branch (MB) to treat bifurcation lesions. It is argued that a drug-eluting Tryton-version is needed to improve clinical outcomes, although previous registries have shown good clinical results. More insights in neo-intimal hyperplasia (NIH) growth patterns of the Tryton treatment strategy are needed to decide if and where to drug-coat the stent. Ten patients returned for follow-up angiography (mean follow-up time 393 ± 103 days) and optical coherence tomography (OCT) pullbacks from the MB were obtained in all patients and ...

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    2. Intravascular Photoacoustic Tomography of Coronary Atherosclerosis

      Intravascular Photoacoustic Tomography of Coronary Atherosclerosis

      The emergence of coronary angiography in the late 1950s enabled an imaging-based understanding of coronary artery disease and led to surgical and intravascular treatment approaches of coronary luminal stenosis. Based on the increasing familiarity with intracoronary catheter manipulation, miniature intravascular ultrasound probes subsequently were developed. The advantage of direct, intraluminal imaging was initially considered to be its capability to clarify indeterminate luminal findings (e.g., severity of left main stenosis, dissection, in-stent restenosis). However, investigators soon realized that the visualization of the wall/plaque beyond the narrowed lumen with intravascular imaging provided important insights into pathophysiologic aspects of atherosclerosis ( 1 ...

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      Mentions: Cleveland Clinic
    3. Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Optical coherence tomography (OCT) is a high-resolution technology for imaging of biological tissues that has shown tremendous potential for intracoronary use. Based on near-infrared light rather than ultrasound, catheter-based OCT provides cross-sectional images of the vessel wall and related devices in a histology-like manner. At present, OCT is primarily being used in research to better characterize and understand the pathophysiology of vulnerable plaques and to study the acute and long-term effects of coronary stent implantation. The present review provides the interventional cardiologist with a summary of the clinical research involving OCT, with an emphasis on specific challenges and how these ...

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      Mentions: Maria D. Radu
    4. Optical coherence tomography applied to tests of skin care products in humans – a case study

      Optical coherence tomography applied to tests of skin care products in humans – a case study

      Background/purpose When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. Methods We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of ...

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    5. Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

      The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for the corneal thicknesses of the entire cornea in different stages of keratoconus.

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    6. Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Anterior Segment Optical Coherence Tomography Imaging of Conjunctival Filtering Blebs after Glaucoma Surgery

      Time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) are cross-sectional, noncontact, highresolution diagnostic modalities for posterior and anterior segment (AS) imaging.The AS-OCT provides tomographic imaging of the cornea, iris, lens, and anterior chamber (AC) angle in several ophthalmic diseases. In glaucoma, AS-OCT is utilized to evaluate the morphology of AS structures involved in the pathogenesis of the disease, to obtain morphometric measures of the AC, to evaluate the suitability for laser or surgical approaches, and to assess modifications after treatment. In patients undergoing surgery, AS-OCT is crucial in the evaluation of the filtering bleb functionality, permitting ...

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    7. OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY DIFFERENCE MAPS AND AVERAGE MACULAR VOLUME FOR GEOGRAPHIC ATROPHY

      Purpose: To demonstrate the ability to monitor geographic atrophy (GA) volumetrically through all retinal layers with high-resolution optical coherence tomography difference maps and average macular volume. Methods: Observational case report. Results: Two patients diagnosed with GA were followed up for multiple years with consecutive high-resolution optical coherence tomography studies along with fundus photography and fluorescein angiography or fundus autofluorescence. Difference maps visually reflect macular thinning associated with expansion of GA witnessed on alternative studies. In addition, these maps show progressive macular thinning within previously delineated areas of GA. Average macular volume quantitatively demonstrates the decreasing volume associated with the expanding ...

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    8. Optical Coherence Tomography in Coronary Artery Disease: Toward Sub cellular Imaging

      Optical Coherence Tomography in Coronary Artery  Disease: Toward Sub cellular Imaging

      Intracoronary optical coherence tomography (OCT) is an interferometric imaging technology that uses near-infrared light to provide cross-sectional images with an axial resolution of 10 μm and a transverse of 20-40 μm in vivo. The imaging capabilities of OCT have enabled visualization of important features of coronary plaque, including thrombus, macrophage, neovascularization, stent implantation and stent strut coverage, which have provided new insights for better understanding of this disease. Frequency domain (FD)-OCT is secondgeneration form of OCT that is able to acquire OCT images at a much higher frame. The high-speed imaging capabilities of FD-OCT have made intravascular OCT practical ...

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    9. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    10. Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include ...

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    11. Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Importance Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. Objective To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert retinal thickness measurements from SD-OCT to equivalent values on TD-OCT. Design, Setting, and Participants A cross-sectional observational study was conducted in private and institutional practices. Persons with diabetes mellitus who had at least 1 eye with central-involved diabetic macular ...

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    12. Highly calcific in-stent restenosis as a substrate for sirolimus-eluting stent very late stent thrombosis

      Highly calcific in-stent restenosis as a substrate for sirolimus-eluting stent very late stent thrombosis

      We describe a case of very late stent thrombosis with documentation of highly calcific restenosis at optical coherence tomography without clear signs of stent malapposition, neoatherosclerosis disruption, or vascular toxicity to stent polymer. To the best of our knowledge, this is one of the first reports dealing with highly calcific restenosis as a potential background to very late stent thrombosis.

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    13. A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      A FALSE COLOR FUSION STRATEGY FOR DRUSEN AND GEOGRAPHIC ATROPHY VISUALIZATION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES

      Purpose: To display drusen and geographic atrophy (GA) in a single projection image from three-dimensional spectral domain optical coherence tomography images based on a novel false color fusion strategy. Methods: We present a false color fusion strategy to combine drusen and GA projection images. The drusen projection image is generated with a restricted summed-voxel projection (axial sum of the reflectivity values in a spectral domain optical coherence tomography cube, limited to the region where drusen is present). The GA projection image is generated by incorporating two GA characteristics: bright choroid and thin retina pigment epithelium. The false color fusion method ...

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    14. DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      DISTRIBUTION OF INTRARETINAL EXUDATES IN DIABETIC MACULAR EDEMA DURING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OBSERVED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FUNDUS PHOTOGRAPHY

      Purpose: To evaluate changes in the distribution and morphology of intraretinal microexudates and hard exudates (HEs) during intravitreal anti-vascular endothelial growth factor therapy in patients with persistent diabetic macular edema. Methods: Twenty-four patients with persistent diabetic macular edema after photocoagulation were investigated in this prospective cohort study. Each eye was assigned to a loading dose of three anti-vascular endothelial growth factor treatments at monthly intervals. Additional single treatments were performed if diabetic macular edema persisted or recurred. Intraretinal exudates were analyzed over 6 months using spectral domain optical coherence tomography (SD-OCT) and fundus photography. Results: Before treatment, microexudates were detected ...

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    15. Viewing Dentistry in a New Light

      Viewing Dentistry in a New Light

      Dental X-rays expose patients to radiation, require time to process, and can only “see” a limited amount inside the mouth. Now new optical techniques developed by UC San Francisco’s Daniel Fried , PhD, use light to take instantaneous digital images that can provide a better picture of our teeth and could one day zap cavities with pinpoint precision. Daniel Fried, PhD, speaks with Leon Chung, a dental research fellow in his lab. Photo by Susan Merrell Fried, a professor in the School of Dentistry’s Division of Biomaterials and Bioengineering in the Department of Preventive and Restorative Dental Sciences, is ...

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    16. Versatile Swept Source With Adjustable Coherence Length

      Versatile Swept Source With Adjustable Coherence Length

      An electronically controlled optical swept source at 1550 nm using mode locking in a dispersive ring cavity is described. Active mode-locking was achieved by directly modulating the current of a semiconductor optical amplifier (SOA) used as a gain medium. In the static regime, parameters such as linewidth, tuning bandwidth, and contrast were measured, whereas the axial range was determined dynamically. Two types of fiber, dispersion compensation and single mode, are employed in the laser ring cavity. It is demonstrated that the relative lengths of the two types of fiber have little effect on the linewidth, whereas more control on the ...

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    17. Inverse scattering solutions using low-coherence light

      Inverse scattering solutions using low-coherence light

      We present a new wave-vector-space approach for solving inverse scattering problems. In our formulation, the theories for diffraction tomography and coherence gating are combined to explain 3D reconstruction with low-coherence light. Specifically, we apply this method to solve the scattering problem with broadband fields for transmission and reflection measurements. Our results can be applied to any interferometric measurements with low-coherence light, including optical coherence tomography, angle-resolved low-coherence interferometry, and white-light diffraction tomography.

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    18. New imaging techniques for nonmuscle invasive bladder cancer

      New imaging techniques for nonmuscle invasive bladder cancer

      Purpose of review: Recent advances in imaging techniques provide innovative tools for the detection of bladder cancer. In patients with nonmuscle invasive cancer, there is a need for enhanced visualization of flat growing lesions and multifocal tumors. The aim of new imaging modalities is the improved detection and staging of bladder lesions, as an adjunct to conventional white light endoscopy. Recent findings: Fluorescence cystoscopy with 5-aminolevulinic acid and hexaminolevulinate has been shown to improve the detection of papillary and flat bladder lesions in comparison to conventional white light cystoscopy. Prospective phase III clinical trials have demonstrated advanced diagnostic ability, enhanced ...

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    19. Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Background While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. Objective Evaluation of the potential of High-Definition Optical Coherence Tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and de-cellularisation. Methods Human skin samples were incubated with four different agents: Dispase II, NaCl 1M, Sodium Dodecyl Sulfate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-Definition Optical Coherence Tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by Reflectance Confocal Microscopy (RCM). (Immuno)histopathology ...

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    20. Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for methods to study the interaction between macrophages and crystalline cholesterol. In this study, we demonstrate the feasibility of detecting cholesterol in macrophages in situ using Micro-Optical Coherence Tomography (µOCT), an imaging modality we have recently developed with 1-µm resolution. Macrophages containing cholesterol crystals frequently demonstrated highly scattering constituents in ...

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    21. Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Astronaut Using Optical Coherence Tomography during an Ocular Health vision Test on the International Space Station

      Flight Engineer Alexander Gerst uses the Optical Coherence Tomography camera during an Ocular Health vision test in the Harmony node of the International Space Station. Commander Steve Swanson (left) assists Gerst. Image credit: NASA. Larger image (1 MB): http://www.nasa.gov/sites/default/files/oh_vision_test.jpg

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    22. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    23. Long-Term Outcomes of Neointimal Hyperplasia Without Neoatherosclerosis After Drug-Eluting Stent Implantation

      Long-Term Outcomes of Neointimal Hyperplasia Without Neoatherosclerosis After Drug-Eluting Stent Implantation

      Objectives The aim of this study was to investigate the correlation between in-stent neointimal tissue without features of neoatherosclerosis and long-term clinical outcomes. Background Recent studies have reported differential morphological characteristics of in-stent neointimal tissue assessed by optical coherence tomography (OCT). Methods The study population consisted of 336 patients with 368 drug-eluting stent-treated lesions. Patients received a follow-up OCT examination without any intervention. OCT-based neointima was categorized as homogeneous (n = 227 lesions in 208 patients), heterogeneous (n = 79 lesions in 73 patients), or layered (n = 62 lesions in 55 patients). Major adverse cardiac events (MACE) (a composite of cardiac death ...

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