1. All Articles

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    1. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dynamics

      University of Washington Receives a 2020 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dynamics. The principal investigator is Tueng Shen. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical properties are closely linked to its primary optical function, its response to surgical interventions, and the results of routine eye tests such as intraocular pressure measurements, corneal biomechanics has not been a topic of major research interest. Topography, tonometry ...

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    2. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives a 2020 NIH Grant for $188,771for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is an application for an Exploratory/Developmental Research Grant which brings together a team of experts in ophthalmic imaging, surgery and robotics to advance the state of the art in image-guided robotic microsurgical intervention. Corneal transplants are one of the most commonly performed allograft procedures worldwide, although there remains a substantial risk of immune rejection or graft failure. An alternative form of corneal transplantation ...

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    3. Optical Coherence Tomography Angiography in Glaucoma Care

      Optical Coherence Tomography Angiography in Glaucoma Care

      Purpose: To provide the reader with information on the principal techniques of optical coherence tomography angiography (OCTA); the current literature on OCTA reproducibility; its applications to glaucoma detection and monitoring of progression; and the role of OCTA in the assessment of the vascular component in glaucoma pathogenesis. Methods: A literature review of the pertinent publications for the OCTA in relation to the development, techniques, and its use in glaucoma was carried out. Results: Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. OCTA ...

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    4. Imaging of Atrioventricular Nodal Conduction Tissue in Porcine Hearts Using Optical Coherence Tomography

      Imaging of Atrioventricular Nodal Conduction Tissue in Porcine Hearts Using Optical Coherence Tomography

      Optical coherence tomography (OCT) employs near-infrared light to image the microstructure of different tissues. Clinically, it has been used to image the walls of coronary arteries. In research settings, one of the applications for OCT is visualizing endocardial and subendocardial structures. The present experiment sought to determine whether OCT can identify native conduction tissues in adult porcine hearts. During the study, the right atrial endocardial surfaces of excised adult porcine hearts were exposed. The triangle of Koch was imaged with the OCT system and the conduction tissue was identified. The area was then prepared for histologic examination with Masson’s ...

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    5. Penetration capability of near infrared Laguerre–Gaussian beams through highly scattering media

      Penetration capability of near infrared Laguerre–Gaussian beams through highly scattering media

      The higher capability of optical vortex beams of penetrating turbid media (e.g., biological fluids) with respect to the conventional Gaussian beams is, for the first time to our knowledge, demonstrated in the 1.3 µm wavelength range which is conventionally used for optical coherence tomography procedures in endoscopic intravascular scenarios. The effect has been demonstrated by performing transmittance measurements through suspensions of polystyrene microspheres in water with various particulate concentrations and, in reflection, by using samples of human blood with different thicknesses. The reduced backscattering/increased transmittance into such highly scattering media of Laguerre–Gaussian beams with respect to ...

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    6. Microangiography method and system based on full-space modulation spectrum splitting and angle compounding

      Microangiography method and system based on full-space modulation spectrum splitting and angle compounding

      A microangiography method and system based on full-space modulation spectrum splitting and angle compounding is disclosed. Label-free three-dimensional optical coherence tomography angiography is realized by combining the three-dimensional space resolution capability of an optical coherence tomography and the motion recognition capability of a dynamic scattering technology. Probe light of different incident angles is encoded with a transverse scanning modulation spectrum in a spatial frequency domain, incident angle-resolved sub-angiograms which are independent of one another are obtained by splitting the modulation spectrum, and an angiogram with multiple space angles compounded is realized. Conjugate mirror images are removed from a depth (z ...

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    7. What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review

      What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review

      Background: Optical coherence tomography (OCT) has recently been introduced in the operating theatre. The aim of this review is to present the actual role of microscope-integrated optical coherence tomography (MI-OCT) in ophthalmology. Method: A total of 314 studies were identified, following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. After full-text evaluation, 81 studies discussing MI-OCT applications in ophthalmology were included. Results: At present, three microscope-integrated optical coherence tomography systems are commercially available. MI-OCT can help anterior and posterior segment surgeons in the decision-making process, providing direct visualization of anatomic planes before ...

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    8. LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp. Receives Small Business Innovation Research Phase II Award from the US National Institutes of Health (NIH)

      LighTopTech Corp., an upstate New York-based company building innovative optical instruments to bring to market disruptive imaging technologies industrial and medical fields, has been awarded a Phase II Small Business Innovation Research (SBIR) award by the National Eye Institute of the National Institutes of Health (NIH). The NIH Phase II award will allow LighTopTech to develop the first 3D high-definition imaging instrument based on Gabor-Domain Optical Coherence Microscopy (GDOCM) for quantitative assessment of corneal tissue at eye banks. LighTopTech will develop and apply machine learning methods to automatically segment the endothelial cells of the cornea and count them to assess ...

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    9. Pulmonary Optical Coherence Tomography in COVID-19 Patients

      Pulmonary Optical Coherence Tomography in COVID-19 Patients

      To evaluate by intravascular OCT study the presence of microvascular pulmonary thrombosis in patients with COVID-19, high D-dimer levels and contrast CT scan negative for pulmonary thrombosis. We'll also evaluate the extension of microvascular pulmonary thrombosis in patients with contrast CT scan positive for pulmonary embolism in areas where contrast CT scan was negative.

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      Mentions: Cordis
    10. 30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      Although intravascular ultrasound (IVUS) is an important tool in guiding complex coronary interventions, the resolution of existing commercial IVUS devices is considerably poorer than that of optical coherence tomography. Dual-frequency IVUS (DF IVUS), incorporating a second, higher frequency transducer, has been proposed as a possible method of overcoming this limitation. Although preliminary studies have shown that DF IVUS can produce complementary images, including large-scale morphology and high detail of superficial features, it has not yet been determined that this approach would be feasible in a more clinically relevant environment. The purpose of this study was to demonstrate the first in ...

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    11. Wide-field optical coherence tomography angiography for the detection of proliferative diabetic retinopathy

      Wide-field optical coherence tomography angiography for the detection of proliferative diabetic retinopathy

      Purpose To compare the ability of wide-field optical coherence tomography angiography (WF-OCTA) to that of ultra-wide field fluorescein angiography (UWF-FA) and ultra-wide-field color fundus photography (UWF-CP) to detect retinal neovascularization (NV) in eyes with proliferative diabetic retinopathy (PDR). Methods In this cross-sectional study, naïve patients with active PDR underwent UWF-FA and UWF-CP using the Optos 200Tx and WF-OCTA with 12 × 12 mm fields of five visual fixations using the PLEX Elite 9000. NV was defined on OCTA when the co-registered B-scan with flow overlay of the vitreoretinal interface (VRI) segmentation showed extraretinal proliferation. Three masked readers examined the UWF-FA ...

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    12. Cross‐scanning optical coherence tomography angiography for eye motion correction

      Cross‐scanning optical coherence tomography angiography for eye motion correction

      We propose a cross‐scanning optical coherence tomography (CS‐OCT) system to correct eye motion artifacts in OCT angiography images. This system employs a dual illumination configuration with two orthogonally polarized beams, each of which simultaneously perform raster scanning in perpendicular direction with each other over the same area. In the reference arm, a polarization delay unit is used to acquire the two orthogonally polarized interferograms with a single photodetector by introducing different optical delay lines. The two cross‐scanned volume data are affected by the same eye motion but in two orthogonal directions. We developed a motion correction algorithm ...

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      Mentions: Korea University
    13. Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology

      Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology

      Purpose To report a carefully studied case of high voltage electrical injury of the retina and optic nerve with anatomically reversible retinoschisis. Methods Observational case report. Results A 22 year old power company worker was electrocuted with 12,000 V, with his left forehead being the exit point of the current. After regaining consciousness he reported decreased vision with both eyes. He was extensively tested with optical coherence tomography (OCT) and angiography (OCT-A), fundus photography, fluorescein angiography (FA), multifocal electroretinography (mfERG), full field electroretinography (ffERG), visual evoked potentials (VEP), and Goldmann-type Octopus automated perimetry in addition to careful clinical examinations ...

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    14. Measurement of optic axis orientation with single-mode fiber-based polarization-sensitive optical coherence tomography

      Measurement of optic axis orientation with single-mode fiber-based polarization-sensitive optical coherence tomography

      An algorithm is presented that can be used to obtain accurate optic axis orientation of birefringent tissue samples. A single-mode fiber (SMF)-based polarization-sensitive optical coherence tomography with a single linearly polarized incident light was used in the measurements in which the light reflected from the sample and detected by the spectrometer is linearly polarized light at 45 deg with respect to the experimental horizontal axis. By employing polarization controllers to completely specify the parameters of the fiber system, the absolute optic axis orientation could then be estimated accurately by analyzing the Mueller matrices of the fiber system and sample ...

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    15. Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis)

      Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis)

      This thesis makes several important contributions to polarisation-sensitive optical coherence tomography (PS-OCT) through developing no el methods to effectively extract local contrast from birefringence and the orientation of the associated optic axis, at conventional and ultra-high resolution.

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    16. Fundus fluorescein angiography and optical coherence tomography findings in ocular and non-ocular Behҫet’s disease

      Fundus fluorescein angiography and optical coherence tomography findings in ocular and non-ocular Behҫet’s disease

      Aim of the work This study aimed at early detection of fundus fluorescein angiography (FFA) findings and optical coherence tomography (OCT) changes denoting active posterior uveitis in Behçet’s Disease (BD) patients before they are clinically evident. Patients and methods This study included 50 BD patients subgrouped according to ocular involvement into ocular and non-ocular Behçet patients. All patients underwent thorough ophthalmological examination. Fundus examination was done to detect signs of intermediate and/or posterior uveitis. OCT conventional and enhanced depth techniques were used for assessment of the macular area and choroidal thickness respectively. FFA was done for ...

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    17. Optical Coherence Tomography as a Diagnostic Adjunct for Ocular Surface Lesions

      Optical Coherence Tomography as a Diagnostic Adjunct for Ocular Surface Lesions

      We describe a series of four cases with ocular surface lesions, where optical coherence tomography (OCT) proved to be a useful tool for diagnosis and/or management. These cases included pterygium with cyst, suspected ocular surface squamous neoplasia, nodular scleritis and an inclusion cyst. The ability of OCT to reveal the internal characteristics and the true location of lesion may help, in judicious decisions regarding excisional biopsy in future.

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    18. The impact of therapeutic mediastinal radiation on stent healing in cancer patients: An optical coherence tomography study.

      The impact of therapeutic mediastinal radiation on stent healing in cancer patients: An optical coherence tomography study.

      Background: Cancer is a prothrombotic and proinflammatory state. Understanding stent healing in cancer patients could modify the approach to antiplatelet regimen and facilitate cancer treatment. Mediastinal radiation therapy brings an additional layer of complexity to an already challenging clinical scenario in cancer patients undergoing percutaneous coronary intervention (PCI). We sought to compare stent healing patterns with and without a history of mediastinal radiation therapy using optical coherence tomography (OCT) data. Methods: All cancer patients that underwent PCI and follow-up OCT less than 12 months post-PCI between 2009-2018 were retrospectively identified from our institutional cardiac catheterization laboratory registry. Stent healing, which ...

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    19. Optical Coherence Tomography and Its Non-medical Applications (Textbook)

      Optical Coherence Tomography and Its Non-medical Applications (Textbook)

      Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhanci...

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    20. Deep learning architectures analysis for age-related macular degeneration segmentation on optical coherence tomography scans

      Deep learning architectures analysis for age-related macular degeneration segmentation on optical coherence tomography scans

      Background and Objectives: Aged people usually are more to be diagnosed with retinal diseases in developed countries. Retinal capillaries leakage into the retina swells and causes an acute vision loss, which is called age-related macular degeneration (AMD). The disease can not be adequately diagnosed solely using fundus images as depth information is not available. The variations in retina volume assist in monitoring ophthalmological abnormalities. Therefore, high-fidelity AMD segmentation in optical coherence tomography (OCT) imaging modality has raised the attention of researchers as well as those of the medical doctors. Many methods across the years encompassing machine learning approaches and convolutional ...

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    21. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and their associated cardiovascular disease. Homology between the eye and the kidney suggests that noninvasive imaging of the retinal vessels can detect these microvascular alterations to improve targeting of at-risk patients ...

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    22. Degree of luminal narrowing and composition of thrombus in plaque erosion

      Degree of luminal narrowing and composition of thrombus in plaque erosion

      As the degree of luminal narrowing increases, shear stress increases, and high shear stress is known to activate platelets. However, the relationship between the degree of luminal narrowing and the composition of thrombus in patients with plaque erosion has not been studied. A total of 148 patients with plaque erosion and thrombus detected by optical coherence tomography were divided into tertiles based on the minimum lumen area (MLA) at the culprit lesion. Thrombus was categorized as platelet-rich or fibrin-rich. Among 148 patients, 50 (34%) were in the mild stenosis group, 49 (33%) were in the moderate stenosis group, and 49 ...

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    23. Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Purpose To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy. Design Observational cases report. Methods Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3. Results Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening. Conclusions In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a ...

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    24. Assessment of Cardiac Allograft Vasculopathy from OCT Images: Automated Analysis is as Good as Expert-Guided Approach

      Assessment of Cardiac Allograft Vasculopathy from OCT Images: Automated Analysis is as Good as Expert-Guided Approach

      Purpose Cardiac Allograft Vasculopathy (CAV) is a frequent complication after heart transplantation (HTx). To help identify patients at risk of CAV, 3D quantitative analysis of coronary wall thickening is of major importance. Until now, substantial manual tracing effort was required. We report a fully automated approach using optical coherence tomography (OCT) imaging. Methods Lumen surface, intimal and medial layers were identified using our LOGISMOS segmentation framework. Coronary wall regions with layered appearance were automatically identified in each OCT frame using deep learning. These segmentation and classification approaches were newly combined in one fully automated system. The comparison between fully automated ...

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