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1. Bioptigen Receives FDA Clearance to Market Envisu Imaging Systems in the USA Explore Optical Coherence Tomography News (4 hours, 43 min ago) Ophthalmology , Other Business News Bioptigen Press Release - Devices become first OCT systems cleared for hand-held ophthalmic imaging of children Bioptigen Inc. has received 510(k) clearance from the U.S. Food and Drug Administration to begin marketing its hand-held Envisu Spectral Domain Ophthalmic Imaging System (SDOIS) devices for patient use. The Envisu SDOIS aids in the diagnosis of physiological and pathological conditions of the eye through non-contact optical imaging. In receiving this regulatory clearance, Bioptigen’s Envisu SDOIS become the first optical coherence tomography imaging systems commercially available in the United States for hand-held and pediatric imaging. Envisu’s ergonomic, hand-held scanner enables imaging ... (Read Full Article)

   Comment Mentions:   National Institutes of Health   Eric L. Buckland   Bioptigen

2. SD-OCT in Pigmented Paravenous Retinochoroidal Atrophy Explore Healio.com (6 hours, 42 min ago) Ophthalmology Pigmented paravenous retinochoroidal atrophy (PPRCA) is a rare disease characterized by bilateral retinochoroidal atrophy and pigmentation along the retinal veins. The authors describe spectral-domain optical coherence tomography (SD-OCT) in a case of PPRCA. The right macula showed a lamellar macular hole. In addition, scans were taken through the affected areas along the retinal veins that revealed the location of the pigment and other features. These findings have not been reported previously. (Read Full Article)

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3. Enhanced Depth Imaging Optical Coherence Tomography: Choroidal Thickness and Correlations With Age, Refractive Error, and Axial Length Explore Healio.com (6 hours, 53 min ago) Ophthalmology BACKGROUND AND OBJECTIVE: To evaluate choroidal thickness at five macular locations and assess the correlations between choroidal thickness at these locations with age, refractive error, and axial length. PATIENTS AND METHODS: Eighty-four eyes from 42 healthy adult volunteers were included. Enhanced depth imaging by spectral-domain optical coherence tomography was performed, and choroidal thickness was measured at five macular locations: subfoveal and 3 mm nasal, temporal, superior, and inferior. Correlations of choroidal thickness at each location with age, refractive error, and axial length were analyzed. RESULTS: Mean choroidal thicknesses at the subfoveal, superior, inferior, temporal, and nasal locations were 293, 308 ... (Read Full Article)

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4. Correlations Between Digital planimetry and optical Coherence tomography, Confocal scanning laser ophthalmoscopy in assessment of optic Disc parameters Explore Medicina (13 hours, 47 min ago) Ophthalmology Objective and Aim. In routine clinical practice, laser methods for the evaluation of optic disc parameters are expensive and not accessible for all ophthalmologists; therefore, there is a need for less expensive technique. The aim of this study was to assess correlations between the parameters of the optic disc measured by digital planimetry (DP), optical coherence tomography (OCT), and confocal scanning laser ophthalmoscopy (CSLO) in healthy and glaucoma patients with the normal biometric parameters of the eye. Material and Methods. This case-control study enrolled 40 patients with glaucoma and 32 healthy patients with the normal biometric parameters of the eye ... (Read Full Article)

   Comment Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

5. Analysis of the efficiency of hair removal by different optical methods: comparison of Trichoscan, reflectance confocal microscopy, and optical coherence tomography Explore Linking to Scitation Content (13 hours, 52 min ago) Dermatology Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and hair growth after hair removal for a defined period of five days. The application of these techniques was demonstrated by measuring hair growth on the lower leg of six female volunteers. After removal of the hair shaft with a shaving system, the hair follicle infundibula and the length of the growing hairs were ... (Read Full Article)

   Comment Mentions:   Thorlabs

6. Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system Explore SpringerLink Home (14 hours, 1 minute ago) Ophthalmology BACKGROUND: We have recently developed a microscope-integrated spectral-domain optical coherence tomography (MIOCT) device towards intrasurgical cross-sectional imaging of surgical maneuvers. In this report, we explore the capability of MIOCT to acquire real-time video imaging of vitreoretinal surgical maneuvers without post-processing modifications. METHODS: Standard 3-port vitrectomy was performed in human during scheduled surgery as well as in cadaveric porcine eyes. MIOCT imaging of human subjects was performed in healthy normal volunteers and intraoperatively at a normal pause immediately following surgical manipulations, under an Institutional Review Board-approved protocol, with informed consent from all subjects. Video MIOCT imaging of live surgical manipulations was ... (Read Full Article)

   Comment Mentions:   Joseph A. Izatt   Duke University   Paul Hahn

7. Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD Explore iovs.org (May 16 2012) Ophthalmology Purpose: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tomography (SDOCT) hyperreflective foci in eyes with non-advanced AMD. Methods: A prospective cross-sectional analysis of 314 eyes (314 subjects) with intermediate AMD was performed in the multicenter AREDS2 Ancillary SDOCT Study to correlate hyperpigmentary changes on color fundus photographs (CFP) with abnormal morphology on SDOCT. Spatial coregistration was performed with an automated algorithm in 2 non-overlapping subsets of 20 study eyes with double-masked CFP and SDOCT grading by certified ... (Read Full Article)

   Comment Mentions:   National Institutes of Health   Duke University   Cleveland Clinic

8. Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using optical coherence tomography Explore iovs.org (May 16 2012) Neurology , Ophthalmology Objective: To compare retinal nerve fiber layer (RNFL) and macular thickness measurements in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO) with or without history of optic neuritis and in controls using Fourier-domain (FD) optical coherence tomography (OCT). Methods: Patients with MS (n=60), NMO (n=33), longitudinal extensive transverse myelitis (LETM) (n=28) and healthy controls (n=41) were submitted to ophthalmic examination, including automated perimetry, and to FD-OCT RNFL and macular thickness measurements. Five groups of eyes were compared: MS with or without previous optic neuritis, NMO, LETM and controls. Correlation between OCT and visual field (VF ... (Read Full Article)

   Comment Mentions:   University of São Paulo

9. Morphologic Analysis in Pathologic Myopia Using High-Penetration Optical Coherence Tomography Explore iovs.org (May 16 2012) Ophthalmology PURPOSE. To retrospectively evaluate the morphologic choroidal and scleral characteristics in eyes with pathologic myopia using high-penetration optical coherence tomography (HP-OCT). METHODS. The subfoveal choroidal and scleral thicknesses were measured using the prototype HP-OCT with a 1,060-nm light source. We also measured the scleral thickness 3 mm superior, inferior, nasal, and temporal to the fovea on the horizontal and vertical OCT sections. The axial length (AL) in all eyes was measured using optical biometry. RESULTS. Fifty-eight eyes of 35 patients (7 men, 28 women; mean age, 65.5 years) with an AL exceeding 26.5-mm were examined. The mean ... (Read Full Article)

   Comment Mentions:   Topcon Medical Systems   Masahiro Akiba

10. Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters Explore eurointervention.org (May 16 2012) Cardiology Aims: The aim of this study was to assess the ability of optical coherence tomography (OCT) to guide recrossing during percutaneous coronary interventions in bifurcations and to reduce strut malapposition. (Read Full Article)

    Comment Mentions:   Imperial College London   Carlo Di Mario   Royal Brompton Hospital

11. Coronary artery perforation imaged through 3-dimensional optical coherence tomography Explore eurointervention.org (May 16 2012) Cardiology A 54-year-old man with non-ST elevation myocardial infarction (NSTEMI) underwent percutaneous coronary intervention (PCI) for a severe stenosis in the first marginal branch of the left circumflex coronary artery (LCx-OM1) (Figure 1). (Read Full Article)

    Comment Mentions:   Terumo Cardiovascular Systems   Francesco Prati

12. Optical coherence tomography for biofilm detection in chronic rhinosinusitis with nasal polyposis Explore SpringerLink Home (May 16 2012) Otolaryngology Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease that seems to be associated with the presence of microbial biofilms and corresponding subepithelial inflammatory reactions. Optical coherence tomography (OCT) might be applied to detect bacterial and fungal biofilms in patients with CRSwNP. A total of 27 patients with CRSwNP undergoing endoscopic sinus surgery (ESS) were analyzed. The negative control group consisted of six patients undergoing septoplasty for nasal obstruction without CRSwNP. The nasal polyps and inferior turbinate mucosa specimens applied as negative controls were processed to OCT analysis and H.E. and Gram staining. Biofilm was detected in 22 ... (Read Full Article)

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13. Offline fusion of co-registered intravascular ultrasound and frequency domain optical coherence tomography images for the analysis of human atherosclerotic plaques Explore eurointervention.org (May 16 2012) Cardiology Aims: To demonstrate the feasibility and potential usefulness of an offline fusion of matched optical coherence tomography (OCT) and intravascular ultrasound (IVUS)/virtual histology (IVUS-VH) images. (Read Full Article)

    Comment Mentions:   Patrick W. Serruys   Hector M. Garcia-Garcia   University of Bern

14. Optic Nerve Head Quantification in Idiopathic Intracranial Hypertension by Spectral Domain OCT Explore PLoS ONE (May 15 2012) Neurology , Ophthalmology Objective To evaluate 3D spectral domain optical coherence tomography (SDOCT) volume scans as a tool for quantification of optic nerve head (ONH) volume as a potential marker for treatment effectiveness and disease progression in idiopathic intracranial hypertension (IIH). Design and Patients Cross-sectional pilot trial comparing 19 IIH patients and controls matched for gender, age and body mass index. Each participant underwent SDOCT. A custom segmentation algorithm was developed to quantify ONH volume (ONHV) and height (ONHH) in 3D volume scans. Results Whereas peripapillary retinal nerve fiber layer thickness did not show differences between controls and IIH patients, the newly developed ... (Read Full Article)

    Comment Mentions:   Heidelberg Engineering   Heidelberg Spectralis

15. One-step Continuous Synthesis of Biocompatible Gold Nanorods for Optical Coherence Tomography Explore RSC Publishing Home (May 15 2012) We present a one-step flow process to synthesize biocompatible gold nanorods with tunable absorption and bio-compatible surface ligands. Photothermal optical coherence tomography (OCT) of human breast tissue is demonstrated successfully using tailored gold nanorods designed to have strong absorption in the near infrared wavelength range. (Read Full Article)

    Comment Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Chao Zhou

16. Axial resolution improvement by modulated deconvolution in Fourier domain optical coherence tomography Explore Linking to Scitation Content (May 15 2012) Ophthalmology A novel technique for axial resolution improvement in Fourier domain optical coherence tomography (FDOCT) is presented. The technique is based on the deconvolution of modulated optical coherence tomography signals. In FDOCT, the real part of the Fourier transform of the interferogram is modulated by a frequency which depends on the position of the interferogram in k space. A slight numerical k shift results in a different modulation frequency. By adding two shifted signals, beating can appear in the A-scan. When the amount of shifting is appropriately selected, deconvolution of the resulting depth profile, using suitable modulated kernels, yields a narrower ... (Read Full Article)

    Comment Mentions:   Costas D. Pitris   University of Cyprus

17. Endoscopic optical coherence tomography device for forward imaging with broad field of view Explore Linking to Scitation Content (May 15 2012) Otolaryngology One current challenge of studying human tympanic membranes (TM) with optical coherence tomography (OCT) is the implementation of optics that avoid direct contact with the inflamed tissue. At the moment, no commercial device is available. We report an optics design for contactless forward imaging endoscopic optical coherence tomography (EOCT) with a large working distance (WD) and a broad field of view (FOV) by restricting the overall diameter of the probe to be small (3.5 mm), ensuring a sufficient numerical aperture. Our system uses a gradient-index (GRIN) relay lens and a GRIN objective lens, and executes a fan-shaped optical scanning ... (Read Full Article)

    Comment Mentions:   Julia Walther   Dresden University of Technology   Edmund Koch

18. Tissue surface as the reference arm in Fourier domain optical coherence tomography Explore Linking to Scitation Content (May 15 2012) We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image ... (Read Full Article)

    Comment Mentions:   University of St. Andrews   Nikola Krstajic

19. Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries Explore Linking to Scitation Content (May 15 2012) The authors describe the development of an ultrafast three-dimensional (3D) optical coherence tomography (OCT) imaging system that provides real-time intraoperative video images of the surgical site to assist surgeons during microsurgical procedures. This system is based on a full-range complex conjugate free Fourier-domain OCT (FD-OCT). The system was built in a CPU-GPU heterogeneous computing architecture capable of video OCT image processing. The system displays at a maximum speed of 10  volume/?startsend? for an image volume size of 160×80×1024 (X×Y×Z) pixels. We have used this system to visualize and guide two prototypical microsurgical maneuvers: microvascular anastomosis ... (Read Full Article)

    Comment Mentions:   Johns Hopkins University   Jin U. Kang   Kang Zhang

20. Methods, systems and computer program products for mixed-density optical coherence tomography (OCT) imaging Explore uspto.gov (May 15 2012) Patents Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set. (Read Full Article)

    Comment Mentions:   Eric L. Buckland   Cynthia A. Toth   Bioptigen

21. In vivo structural and flow imaging Explore uspto.gov (May 15 2012) Patents , Doppler Embodiments of the present invention include but are not limited to methods and systems for optical coherence imaging. A method for optical coherence imaging may comprise scanning a sample with an incident beam from a light source; detecting one or more spectral interference signals from the sample; modulating the one or more spectral interference signals by a linear translation of a reference mirror while scanning the sample in a cross-sectional direction; and obtaining at least one image of the sample from the modulated one or more spectral interference signals, the at least one image including a selected one of a ... (Read Full Article)

    Comment Mentions:   Oregon Health & Science University   Ruikang K. Wang

22. Fitting a neural prosthesis using impedance and electrode height Explore uspto.gov (May 15 2012) Ophthalmology , Patents The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement. (Read Full Article)

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23. Detection of progressive macular thickness loss using optical coherence tomography in glaucoma suspect and glaucomatous eyes Explore Nature Publishing Group (May 14 2012) Ophthalmology Aims To examine the rate of macular thickness loss using time-domain optical coherence tomography (OCT) in functionally progressing versus non-progressing eyes, determined by standard automated perimetry (SAP). Methods Glaucoma suspects (GS) and glaucomatous (G) eyes underwent SAP and OCT imaging every 6 months. Functional progression was determined using pointwise linear regression, defined as 2 contiguous locations losing ≥1.0 dB/year at P<1.0% in the same hemifield. The annual rate of macular thickness loss was calculated from inner and outer regions of the macular map. Results 72 eyes (43 GS and 29G) with ≥30 months of follow-up were enroled. Fourteen eyes demonstrated SAP progression. The annual rate of macular thickness loss (μm/year) in progressing eyes was faster (all P<0.05) than non-progressing eyes in temporal outer (−1.90±2.97 vs 0.33±2.77), nasal inner (−1.70±2.66 vs 0.14±2.76), superior inner (−2.15±4.57 vs 0.51±2.99), temporal inner quadrants (−2.58±5.05 vs −0.38±2.34), and the average of inner macular quadrants (−1.84±2.90 vs 0.03±2.10). The rate of loss in the nasal inner (P=0.02) and temporal outer (P=0.02) macular regions was associated with optic disc haemorrhage. Conclusions Eyes with SAP progression have significantly greater rates of macular thickness loss consistent with glaucomatous retinal ganglion cell atrophy, as compared with non-progressing eyes. (Read Full Article)

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24. Differentiation Between Normal Renal Tissue and Renal Tumours Using Functional Optical Coherence Tomography: A Phase I In Vivo Human Study Explore Wiley Online Library (May 14 2012) Urology No abstract provided. (Read Full Article)

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