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Popular Articles
The Evolution of Spectral Domain OCT
Ophthalmic Optical Coherence Tomography Market: Past, Present, & Future
Lightlab Imaging, Axsun Technologies, and Volcano Corporation in Legal Dispute
Morphology and Epidermal Thickness of Normal Skin Imaged by Optical Coherence Tomography.
GE Healthcare and LightLab Imaging Inc. Collaborate on Cardiovascular Imaging
Serious complications of cosmetic NewColorIris implantation
Still evolving, OCT technology has revolutionized diagnostics
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Optical Coherence Tomography News
OCT Guidance for Femtosecond Laser Treatment of Presbyopia
Australia & New Zealand Optical Coherence Tomography Workshop May 7th, 2010
1st Massachusetts General Hospital OCT Registry Symposium Scheduled for March 13, 2010
Cement not included – 10:1 return on investment from federal infrastructure investment in photonics
Measurements of Biomechanics by Dynamic Optical Coherence Elastography
Manual-Scanning Optical Coherence Tomography (OCT) Probe Based on Position Tracking
Lightlab Imaging, Axsun Technologies, and Volcano Corporation in Legal Dispute – Part II
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OCT Products in the News
(276 articles) Zeiss Stratus OCT
(90 articles) Zeiss Cirrus HD-OCT
(85 articles) Zeiss Visante OCT
(65 articles) Heidelberg Spectralis
(47 articles) Optovue RTVue-100
(41 articles) Lightlab ImageWire
(34 articles) Lightlab M3 Imaging Console
(25 articles) Topcon 3D OCT-1000
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Organizations in the News
(182 articles) Massachusetts Institute of Technology
(140 articles) Harvard University
(110 articles) Duke University
(109 articles) Massachusetts General Hospital
(94 articles) Medical University of Vienna
(93 articles) Keck School of Medicine
(74 articles) University of Miami
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Optical Coherence Tomography of the Larynx Using the Niris System
Explore Article BCDecker (3 hours, 18 min ago) Otolaryngology
OBJECTIVES:To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.METHODS:Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 μm and a depth scanning range of 2.2 mm, obtaining images of 200 × 200 pixels ...
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Comment on Article Mentions: Imalux Zhongping Chen Jeong H. Kim
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Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology
Explore Article PR Newswire (6 hours, 38 min ago) Cardiology , Other Business News
e ABSORB trial is a prospective, non-randomized (open label), two-phase study that enrolled 131 patients from Australia, Belgium, Denmark, France, the Netherlands, New Zealand, Poland and Switzerland. Key endpoints of the study include assessments of safety – MACE and treated site thrombosis rates – at 30 days; six, nine, 12, 18 and 24 months; with additional annual clinical follow-up for up to five years, as well as an assessment of the acute performance of the bioresorbable vascular scaffold, including successful deployment of the system. Other key endpoints of the study include imaging assessments by angiography, intravascular ultrasound (IVUS), optical coherence ... (Read Full Article)
Comment on Article Mentions: Patrick W. Serruys Thoraxcenter at Erasmus University Medical Center
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Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography
Explore Article Optical Coherence Tomography News (19 hours, 58 min ago) Ophthalmology
Feature Of The Week 3/14/10: Photoacoustic Ophthalmoscopy (PAOM) is based on Laser-scanning Optical Resolution Photoacoustic Microscopy (LS-OR-PAM), which is a branch of photoacoustic microscopy (PAM). LS-OR-PAM was first developed with the collaboration of Dr. Hao Zhang's lab at University of Wisconsin-Milwaukee and Dr. Shuliang Jiao lab at University of Southern California. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high ...
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Comment on Article Mentions: Shuliang Jiao University of Wisconsin Keck School of Medicine
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A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa
Explore Article iovs.org (Mar 14 2010) Ophthalmology
Purpose: To explore the relationship between visual field sensitivity and photoreceptor layer thickness in patients with retinitis pigmentosa (RP). Methods: Static automated perimetry with Humphrey Field Analyzer (central 30-2 threshold program with spot size III) and frequency domain optical coherence tomography (fd-OCT) scans with Spectralis HRA+OCT were obtained from 10 age-matched normal controls and 20 patients with RP retaining good central vision (better than 20/32). The OS+ thickness [the distance between retinal pigment epithelium (RPE)/Bruch's membrane (BM) to the photoreceptor inner-outer segment junction], outer nuclear layer (ONL) and total retinal thickness were measured at locations corresponding to visual field test ... (Read Full Article)
Comment on Article Mentions: Heidelberg Spectralis Columbia University Heidelberg Engineering
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Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats
Explore Article ScienceDirect (Mar 14 2010) Neurology , Ophthalmology
Purpose To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants. Methods Donor retinal sheets were isolated from E19 fetuses of transgenic rats expressing human alkaline phosphatase (hPAP), and transplanted to the subretinal space of 19–56 days old S334ter-3 rat recipients with fast retinal degeneration (average age at surgery 32 days). A total of 143 rats were imaged 1 day to 2.8 months after surgery, using a Fourier-domain optical coherence tomography (FDOCT) system, with an axial resolution of 3.5 μm. The CCD A-line integration time was set at 200 μs ...
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Comment on Article Mentions: Zhongping Chen UC Irvine
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Fundus Autofluorescence, Optical Coherence Tomography, and Electroretinogram Findings in Choroidal Sclerosis
Explore Article LWW Online (Mar 14 2010) Ophthalmology
Purpose: The purpose of this study was to describe fundus autofluorescence (FAF), optical coherence tomography, and electroretinogram findings in choroidal sclerosis. Methods: This is a retrospective case series. Eight eyes of four patients with choroidal sclerosis were evaluated with FAF, optical coherence tomography, and electroretinogram testing. Results: In all eight eyes, FAF imaging showed hypofluorescent placoid lesions corresponding to areas of chorioretinal atrophy seen on stereo biomicroscopy. Prominent hyperfluorescent linear markings underlying regions of atrophic disease were observed in all eyes, likely representative of normal choroidal vessel autofluorescence. In two eyes, FAF showed punctate hypofluorescent lesions in the fovea that ... (Read Full Article)
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Optical coherence tomography in diabetic macular edema
Explore Article LWW Online (Mar 14 2010) Ophthalmology
Purpose of review: Because optical coherence tomography (OCT) has developed quite rapidly in recent years, the purpose of this review is to synthesize much of the recent literature on the use of OCT in the diagnosis and management of diabetic macular edema (DME). Recent findings: OCT has become increasingly utilized in clinical management and in research protocols in the approach to DME. Spectral domain OCT has given clinicians and researchers an even greater pathophysiologic understanding of DME. Summary: OCT has now added another quantitative dimension in the assessment of DME and could lead to better visual outcomes via earlier detection ... (Read Full Article)
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Can preoperative anterior chamber angle width predict magnitude of intraocular pressure change after cataract surgery?
Explore Article NRC Research Press Publishing Services (Mar 13 2010) Ophthalmology
Objective: To determine whether preoperative anterior chamber angle width, captured by anterior segment optical coherence tomography (AS-OCT), can be a predictor of intraocular pressure (IOP) change following cataract surgery. Design: Prospective comparative observational study. Participants: Fifty-three eyes of 53 patients awaiting cataract surgery were included. Methods: Measurement of anterior chamber angle width and IOP using AS-OCT and Goldmann’s applanation tonometry, respectively, were performed before and 6 months after phacoemulsification and intraocular lens implantation. Preoperative and postoperative measurements were compared using paired t test. The prediction rule defined success as ≥20% IOP reduction from the baseline preoperative IOP measurement. Multivariate regression ...
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Comment on Article Mentions: Carl Zeiss Meditec Zeiss Visante OCT
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Volcano Announces Activities at the ACC 2010
Explore Article ptca.org (Mar 12 2010) Cardiology , Other Business News
March 11, 2010 -- San Diego -- Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision intravascular therapy guidance tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, announced today its participation in the Annual Scientific Sessions of the American College of Cardiology (ACC) Conference from March 14th to March 16th in Atlanta, GA. "The Percutaneous Coronary Intervention (PCI) procedures that benefit from our technology are very complex, often involving multi-vessel disease, bifurcations, left mains, chronic total occlusions, intermediate lesions, or various combinations," commented Joe Burnett, Executive Vice President at Volcano. "Our message, ... (Read Full Article)
Comment on Article Mentions: GE Healthcare Siemens Volcano
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Volcano Expands Access to FFR with Ability to Integrate with the Majority of Hemodynamic Monitoring Systems
Explore Article PR Newswire (Mar 12 2010) Cardiology , Other Business News
SAN DIEGO, March 12 /PRNewswire-FirstCall/ -- Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision intravascular therapy guidance tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, announced today its Fractional Flow Reserve (FFR) technology can now integrate with the FFR modules of hemodynamic monitoring systems from GE, Siemens, McKesson, and Mennen. "Utilization of Volcano's physiology (functional measurement) products has grown 79% in the last year, driven primarily by the landmark FAME data and recent elevation of the level of evidence for FFR in the ACC/AHA/SCAI PCI Guidelines to Level A," commented Scott ... (Read Full Article)
Comment on Article Mentions: GE Healthcare Siemens Volcano
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Ultra-high speed full range complex spectral domain optical coherence tomography for volumetric imaging at 140,000 A scans per second
Explore Article SPIE Digital Library (Mar 11 2010) Ophthalmology
We demonstrate an ultra-high speed full rang spectral domain optical coherence tomography system based on CMOS camera at 140,000 A-scans per second. By implementing beam-offset method, a constant modulation frequency is introduced into each B-scan that enables the reconstruction of the full range complex SDOCT images from in vivo biological specimens. To make use of the full acquisition capacity of detection camera used in the system, we developed system control software that streams the raw spectral fringe data directly into the computer memory. The feasibly of our high speed full range SDOCT system is demonstrated for imaging the dynamics of ...
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Comment on Article Mentions: Ruikang K. Wang Lin An Oregon Health & Science University
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Lihong Wang and Hsin-I Wu receive Goodman Book Writing Award from SPIE and OSA
Explore Article Home: SPIE.org (Mar 11 2010)
BELLINGHAM, Washington, and WASHINGTON, D.C., USA -- Lihong V. Wang and Hsin-I Wu are recipients of the 2010 Joseph W. Goodman Book Writing Award for their book Biomedical Optics: Principles and Imaging, the Optical Society (OSA) and SPIE have announced. The Goodman Award, a biennial award funded by a personal gift from Joseph W. and Hon Mai Goodman, recognizes a recent and outstanding book in the field of optics and photonics that has contributed significantly to research, teaching, or the optics and photonics industry. This year, the Goodman Book Writing Award will be bestowed upon Wang and Wu at the ...
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Comment on Article Mentions: Lihong V. Wang Texas A&M University Hsin-i Wu
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Swings and roundabouts: Intravascular Optical Coherence Tomography (OCT) in the evaluation of the left main stem coronary artery
Explore Article International Journal of Cardiology (Mar 11 2010) Cardiology
The imaging detail provided by Intravascular Ultrasound (IVUS) has contributed to 2 recent advances in the treatment of atherosclerotic left main stem coronary artery disease. First, the imaging of stent strut expansion has contributed to an increasing acceptance of left main stem stenting as an alternative to surgery , and second, precise measurements of the plaque area and residual lumenal area have allowed for improved quantification of left main lesion severity . (Read Full Article)
Comment on Article Mentions: University of Sydney
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Correlation Between Morphologic Features on Spectral-Domain Optical Coherence Tomography and Angiographic Leakage Patterns in Macular Edema
Explore Article LWW Online (Mar 11 2010) Ophthalmology
Purpose: The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular edema, and vein occlusion. Methods: Eighty-seven consecutive patients (107 eyes) with macular edema from 5 different etiologies were imaged by simultaneous scanning laser ophthalmoscopy/OCT to study the morphologic patterns of edema on SD-OCT and then correlated/colocalized with the fluorescein angiographic patterns of leakage. Statistical analysis was done to analyze the differences in the morphologic OCT pattern by different diseases. Results: Spectral-domain OCT ... (Read Full Article)
Comment on Article Mentions: UCSD Francesca Mojana Igor Kozak
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Nanoshells for Photothermal Cancer Therapy
Explore Article SpringerLink Home (Mar 11 2010) Oncology
Cancer is a leading cause of death in the United States and contributes to yearly rising health care costs. Current methods of treating cancer involve surgical removal of easily accessible tumors, radiation therapy, and chemotherapy. These methods do not always result in full treatment of the cancer and can in many cases damage healthy cells both surrounding the tissue area and systemically. Nanoshells are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near-infrared (NIR) region where light transmits deeply into tissue. When injected systemically, these particles have been shown to accumulate in the tumor due ...
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Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy
Explore Article SpringerLink Home (Mar 11 2010) Oncology
Gold nanorods (GNRs) are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics. GNRs can support nonlinear optical microscopies based on two-photon-excited luminescence and can enhance the contrast of biomedical imaging modalities such as optical coherence tomography and photoacoustic tomography. GNRs are also efficient at mediating the conversion of NIR light energy into heat and can generate localized photothermal effects. However, future clinical applications will require the rigorous removal of CTAB, a micellar surfactant used in GNR synthesis, and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific ...
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Comment on Article Mentions: Purdue University Alexander Wei
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Potential of optical coherence tomography for early diagnosis of oral malignancies
Explore Article Expert Reviews (Mar 11 2010) Oncology
With nearly 1,500,000 new patients diagnosed every year in the USA, cancer poses a considerable challenge to healthcare today. Oral cancer is responsible for a sizeable portion of deaths due to cancer, primarily because it is diagnosed at a late stage when the prognosis is poor. Current methods for diagnosing oral cancer need to be augmented by better early detection, monitoring and screening modalities. A new approach is needed that provides real-time, accurate, noninvasive diagnosis. The results of early clinical trials using in vivo optical coherence tomography for the diagnosis of oral dysplasia and malignancy are encouraging. (Read Full Article)
Comment on Article Mentions: UC Irvine Petra Wilder-Smith
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High Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration
Explore Article iovs.org (Mar 11 2010) Ophthalmology
Purpose: To investigate to use of high resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVM) associated with exudative age-related macular degeneration (eAMD). Methods: An Fd-OCT instrument with axial resolution of 4 to 4.5 µm and transverse resolution of 10 to 15 µm was used to image 21 eyes (19 subjects) with newly-diagnosed eAMD. A raster series of 100 B-scans separated by 60 µm was used study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed 3-dimensional macular volume. Results: A highly reflective subretinal ... (Read Full Article)
Comment on Article Mentions: UC Davis Robert J. Zawadzki Susanna S. Park
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Early trabeculectomy bleb walls on anterior-segment optical coherence tomography
Explore Article SpringerLink Home (Mar 11 2010) Ophthalmology
Background To correlate the cross-sectional features of filtering blebs on anterior-segment optical coherence tomography (AS-OCT) 2 weeks after trabeculectomy with bleb function at 6 months. Methods Forty-eight eyes followed for 6 months or more after trabeculectomy with mitomycin C were included. Bleb wall reflectivity of developing blebs on AS-OCT 2 weeks postoperatively was correlated with mature bleb function at 6-month postoperative visit. Results Developing bleb walls at 2 weeks were classified as uniform in 10/48 eyes (20.8%) and multiform in 38/48 eyes (79.2%). Blebs with uniform reflectivity were significantly more likely to have worse function at 6 months (P < 0.001). Multiform ...
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Comment on Article Mentions: Kyoto University Graduate School of Medicine Masanori Hangai Nagahisa Yoshimura
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MP learns about key issues for people with sight loss
Explore Article politics.co.uk (Mar 11 2010) Ophthalmology
At a recent Parliamentary reception, Andrew Miller, MP for Ellesmere Port and Neston, met blind and partially sighted campaigners who are working at local level to secure a better deal for people with sight loss. The event celebrated the work of the cross-party parliamentary group on Eye Health and Visual Impairment, which meets to raise parliamentarians' awareness of issues affecting people with sight loss and on prevention of sight loss. Andrew Miller said "On average around 3,000 people in every parliamentary constituency have sight loss. This was an excellent opportunity for me to learn about the equipment available to people ... (Read Full Article)
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Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography
Explore Article SpringerLink Home (Mar 11 2010) Dermatology , Doppler
We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in blood vessel phantom and in vivo subcutaneous ...
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Comment on Article Mentions: Medical University of Vienna University of Otago Igor V. Meglinski
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Noninvasive Detection of Vulnerable Plaques: Are We There Yet?
Explore Article JACC (Mar 10 2010) Cardiology
We read with great interest the study by Motoyama et al. (1) demonstrating that patients with low-attenuation and positively remodeled plaques—as detected by computed tomography angiography (CTA)—were more likely to suffer from acute coronary syndromes (ACS) during follow-up. A total of 10,037 coronary segments >2 mm in diameter were analyzed in 1,059 patients; after a follow-up >2 years, 15 of these patients suffered ACS. Adverse CTA features (remodelling and/or low attenuation) were powerful predictors of ACS development after adjustment (hazard ratio: 22.8). This study is provocative indeed, considering that, up to now, the diagnosis of vulnerable plaque (VP) (defined as ... (Read Full Article)
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A new device for assessing changes in skin viscoelasticity using indentation and optical measurement
Explore Article www3.interscience.wiley.com (Mar 10 2010) Dermatology
Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ...
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Comment on Article Mentions: Imperial College London University of Limerick
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Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma
Explore Article SpringerLink Home (Mar 10 2010) Ophthalmology
Abstract Background To compare the peripapillary retinal nerve fiber layer (RNFL) thickness in eyes affected by non-arteritic ischemic optic neuropathy (NAION) or glaucoma as determined by optical coherence tomography (OCT). Methods This cross-sectional institutional study included 18 eyes with NAION (at least 6 months since the acute event) and 29 eyes with glaucoma, both having localized visual field (VF) defects confined to one hemifield. Twenty-nine normal subjects served as controls. The fast RNFL thickness protocol (3.4) of the Stratus OCT (Carl Zeiss Meditec, Dublin, CA, USA) was used. The RNFL thickness and inferior maximum/temporal average (Imax/Tavg) and superior maximum/temporal average (Smax/Tavg) data corresponding ...
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Comment on Article Mentions: Zeiss Stratus OCT Carl Zeiss Meditec
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