1. All Articles

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    1. Clinical Case of the Month Leica Microscope with OCT Guidance

      Clinical Case of the Month Leica Microscope with OCT Guidance

      "I have used Leica microscopes for over 12 years. Leica's ability to customize their platform to my needs has been very valuable given my particular needs. As a retina surgeon I rely heavily on my microscope for highresolution visualization during surgery. Leica's introduction of an integrated OCT will serve as an important tool in my educational efforts and I believe that patient outcomes may be enhanced. This technology will surely aid us in our understanding of the vitreoretinal interface and other retinal pathologies requiring surgery."

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      Mentions: Leica
    2. Seeing, understanding how we hear

      Seeing, understanding how we hear

      Cutting-edge technology is giving QEII Health Sciences Centre clinicians a close up look at the inner workings of the human ear. “We are the only place in the world that has managed to measure ear vibrations in humans. We are definitely the furthest ahead,” says Dr. Manohar Bance, QEII ear surgeon. When it comes to middle ear dysfunctions, surgeries to cut open the tympanic membrane, or eardrum, are frequently conducted on patients in attempt to identify problems and restore vibrating connections. Anything that can block the passage of vibrations will lead to hearing loss. Fluid is one thing, which is ...

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    3. The Best Motivations for Photonics Entrepreneurs - An interview with Eric Swanson

      The Best Motivations for Photonics Entrepreneurs - An interview with Eric Swanson

      I figure we have much to learn from a very successful serial photonics entrepreneur, Eric Swanson. Eric is a co-founder or founding board member of five companies: Advanced Ophthalmic Devices, Lightlab Imaging, Sycamore Networks, Acacia Communications, and Curata. These companies have evolved over time and shipped over $1 billion in products worldwide. He is an OSA Fellow, IEEE Fellow, a co-recipient of the 2017 Russ Prize, and an active participant in a variety of volunteer activities. Milton Chang: It is remarkable that OCT has been able to move in 25 years from proof-of-principle to an FDA-approved instrument used pervasively in ...

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    4. Optical Coherence Tomography for the Noninvasive Detection of Elevated Intracranial Pressure A New Role for the Ophthalmologist?

      Optical Coherence Tomography for the Noninvasive Detection of Elevated Intracranial Pressure A New Role for the Ophthalmologist?

      Lumbar puncture is the usual confirmatory procedure for the diagnosis of idiopathic intracranial hypertension. However, the lumbar cerebrospinal fluid pressure does not always reflect the intracranial pressure (ICP), especially in children. 1 Therefore, direct ICP monitoring is the gold standard for ascertainment of ICP. However, this procedure is more invasive, requiring general anesthesia and hospital admission to monitor ICP over a period of days. It also carries low risk for central nervous system infection or injury. Consequently, newer techniques are being devised to noninvasively monitor ICP. 2

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    5. Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study

      Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study

      Purpose: To study whether there is a difference in central macular thickness (CMT) and peripapillary retinal nerve fiber layer (RNFL) thickness between the two eyes of individuals having anisometropia >1 diopter (D) using spectral domain optical coherence tomography (OCT). Material and methods: One hundred and one subjects, 31 with myopic anisometropia, 28 with astigmatic anisometropia, and 42 with hypermetropic anisometropia, were enrolled in the study. After informed consent, detailed ophthalmological examination was performed for every patient including cycloplegic refraction, best corrected visual acuity, slit lamp, and fundus examination. After routine ophthalmic examination peripapillary RNFL and CMT were measured using spectral ...

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    6. Postdoctoral Research in Ophthalmic Imaging at NYU Langone Eye Center

      Postdoctoral Research in Ophthalmic Imaging at NYU Langone Eye Center

      The Ophthalmic Imaging Research Laboratory at the New York University is looking for a Postdoctoral Associate to join our multidisciplinary, innovative and vibrant team of clinicians, engineers, software specialists, and biostatisticians. Our research is mostly funded by federal grants and focused on using advanced imaging devices and tools in order to detect and monitor glaucoma – a leading cause of blindness – and investigate new theories about the cause and pathology of the disease. Our translational research has led to numerous important implication on clinical management. The advertised position will primarily be focused on development of advanced optical imaging approaches and novel ...

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    7. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly imaged by two OCT systems: one system centered at 1,300 nm with 6.5 μm axial resolution and 15 μm lateral resolution, and the other centered at 800 nm ...

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    8. Intraoperative assessment of laryngeal pathologies with optical coherence tomography integrated into a surgical microscope

      Intraoperative assessment of laryngeal pathologies with optical coherence tomography integrated into a surgical microscope

      Objective Endoscopic examination followed by tissue biopsy is the gold standard in the evaluation of lesions of the upper aerodigestive tract. However, it can be difficult to distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical coherence tomography (OCT) is a non-invasive technique which acquires high-resolution, cross-sectional images of tissue in vivo . Integrated into a surgical microscope, it allows the intraoperative evaluation of lesions simultaneously with microscopic visualization. Study Design In a prospective case series, we evaluated the use of OCT integrated into a surgical microscope during microlaryngoscopy to help differentiating various laryngeal pathologies. Methods 33 patients with laryngeal pathologies ...

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    9. Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

      Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

      We demonstrated FF OCM(full field optical coherence microscopy) using an ultrathin forward-imaging SMMF (short multimode fiber) probe of 50 μm core diameter, 125 μm diameter, and 7.4 mm length, which is a typical graded-index multimode fiber for optical communications. The axial resolution was measured to be 2.20 μm, which is close to the calculated axial resolution of 2.06 μm. The lateral resolution was evaluated to be 4.38 μm using a test pattern. Assuming that the FWHM of the contrast is the DOF (depth of focus), the DOF of the signal is obtained at 36 μm ...

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    10. High frame-rate en face optical coherence tomography system using KTN optical beam deflector

      High frame-rate en face optical coherence tomography system using KTN optical beam deflector

      We developed high frame-rate en face optical coherence tomography (OCT) system using KTa 1-x Nb x O 3 (KTN) optical beam deflector. In the imaging system, the fast scanning was performed at 200 kHz by the KTN optical beam deflector, while the slow scanning was performed at 800 Hz by the galvanometer mirror. As a preliminary experiment, we succeeded in obtaining en face OCT images of human fingerprint with a frame rate of 800 fps. This is the highest frame-rate obtained using time-domain (TD) en face OCT imaging. The 3D-OCT image of sweat gland was also obtained by our imaging ...

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    11. Speckle variance optical coherence tomography using an SS-OCT system and an extended k-sampling clock

      Speckle variance optical coherence tomography using an SS-OCT system and an extended k-sampling clock

      is vacant or filled with material having a refractive index different from the tissue, the observed structure is deformed significantly. This deformation artifact can be minimized by filling the cavity with liquid having a refractive index nearly equal to the tissue. Furthermore, by using dynamical OCT method, cavity image intensity can be significantly enhanced compared with the tissue. This image contrast improvement may allow imaging of cavity structures inside deep in tissues. In this paper, we demonstrate good contrast of speckle variance OCT imaging of phantoms. A trial of deep OCT imaging is introduced with which we can extend the ...

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    12. Master/slave: the ideal tool for coherence revival based optical coherence tomography imaging instruments

      Master/slave: the ideal tool for coherence revival based optical coherence tomography imaging instruments

      In this communication, we present the utility of the Master/Slave (MS) method in combination with the coherence revival technique to obtain full axial range Optical Coherence Tomography (OCT) cross-section images. The MS method eliminates two major drawbacks of the conventional Fourier Transformed (FT) based OCT technology when applied to the coherence revival technique: the need of data re-sampling as well as the need to compensate for unbalanced dispersion in the interferometer.

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    13. Ultralong-range optical coherence tomography-based angiography by akinetic swept source

      Ultralong-range optical coherence tomography-based angiography by akinetic swept source

      Most of current OCT-based angiography suffers from small FOV with short imaging range. Here we implement an ultralong-range OCT system for vascular imaging based on an akinetic swept source. This swept-source OCT (SS-OCT) system enables us to achieve up to 46 mm long imaging range with unprecedented roll-off performance. To compare with traditional spectral domain OCT (SD-OCT) system, we demonstrated the vascular imaging of the entire mice brain with wide FOV by this ultralong-range SS-OCT system and captured the blood flow images at different depth position, which shows the great advantages and bright future of this ultralong-range SS-OCT in vascular ...

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    14. Dual-beam angular compounding for speckle reduction in optical coherence tomography

      Dual-beam angular compounding for speckle reduction in optical coherence tomography

      Optical coherence tomography (OCT), as a low-coherence interferometric imaging technique, inevitably suffers from speckle noise, which can reduce image quality and signal-to-noise (SNR). In this paper, we present a dual-beam angular compounding method to reduce speckle noise and improve SNR of OCT image. Two separated parallel light beams are created on the sample arm using a 1x2 optical fiber coupler and are focused into samples at different angles. The epi-detection scheme creates three different light path combinations of these two light beams above. The three combinations produce three images in single B-scan, which are completely separated in depth. The three ...

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    15. Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Optical Coherence Tomography (OCT) offers real-time high-resolution three-dimensional images of tissue microstructures. In this study, we used OCT skin images acquired from ten volunteers, neither of whom had any skin conditions addressing the features of their anatomic location. OCT segmented images are analyzed based on their optical properties (attenuation coefficient) and textural image features e.g., contrast, correlation, homogeneity, energy, entropy, etc. Utilizing the information and referring to their clinical insight, we aim to make a comprehensive computational model for the healthy skin. The derived parameters represent the OCT microstructural morphology and might provide biological information for generating an atlas ...

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    16. High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

      High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

      In this study, we developed and applied highly-scattering large gold nanorods (LGNRs) and custom spectral detection algorithms for high sensitivity contrast-enhanced optical coherence tomography (OCT). We were able to detect LGNRs at a concentration as low as 50 pM in blood. We used this approach for noninvasive 3D imaging of blood vessels deep in solid tumors in living mice. Additionally, we demonstrated multiplexed imaging of spectrally-distinct LGNRs that enabled observations of functional drainage in lymphatic networks. This method, which we call MOZART, provides a platform for molecular imaging and characterization of tissue noninvasively at cellular resolution

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    17. Gold nanoparticles evaluation using functional optical coherence tomography

      Gold nanoparticles evaluation using functional optical coherence tomography

      The main object of this research was to assess the ability to characterize the gold nanoparticles using optical modalities like optical coherence tomography. Since the nanoparticles, especially gold one, have been very attractive for medical diagnosis and treatment the amount of research activities have been growing rapidly. The nanoparticles designed for different applications like contrast agents or drugs delivery change the optical features of tissue in different way. Therefore, the expanded analysis of scattering optical signal may lead to obtain much more useful information about the tissues health and the treatment efficiency. The noninvasive measurements of the concentration and distribution ...

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    18. High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      We propose a maximum a-posteriori (MAP) intensity estimator to improve the image contrast of polarization diversity (PD)-OCT imaging to achieve high contrast polarization-artifact-free images. The MAP estimator compensates for the inevitable reduction of signal-to-noise ratio (SNR) in PD-OCT caused by the splitting of power into two polarization detection channels. It also has low noise-offset in low intensity regions such as the vitreous. This method is applied to posterior eye images, and shows high-contrast, polarization-artifact-free images. This method also enables attenuation coefficient imaging with finer differentiation of attenuation levels.

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    19. Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal imaging systems that combine scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) have demonstrated the utility of concurrent en face and volumetric imaging for aiming, eye tracking, bulk motion compensation, mosaicking, and contrast enhancement. However, this additional functionality trades off with increased system complexity and cost because both SLO and OCT generally require dedicated light sources, galvanometer scanners, relay and imaging optics, detectors, and control and digitization electronics. We previously demonstrated multimodal ophthalmic imaging using swept-source spectrally encoded SLO and OCT (SS-SESLO-OCT). Here, we present system enhancements and a new optical design that increase our SS-SESLO-OCT data throughput ...

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    20. Classification of human ovarian tissue using full field optical coherence tomography

      Classification of human ovarian tissue using full field optical coherence tomography

      The feasibility of a full-field optical coherence tomography (FFOCT) system for rapid wide field optical analysis of normal and malignant human ovarian tissue pathologies was demonstrated. Five features were extracted from the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples.

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    21. Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

      Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

      Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at ~1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of ~10 nanometers, the proposed 4D ...

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    22. Design and optimization of a miniaturized imaging probe for simultaneous endomicroscopy and optical coherence tomography

      Design and optimization of a miniaturized imaging probe for simultaneous endomicroscopy and optical coherence tomography

      A highly-integrated MEMS-based bimodal probe design with integrated piezoelectric fiber scanner for simultaneous endomicroscopy and optical coherence tomography (OCT) is presented. The two modalities rely on spectrally-separated optical paths that run partially in parallel through a micro-optical bench system, which has dimensions of only 13 x 2 x 3mm 3 (l x w x h). An integrated tubular piezoelectric fiber scanner is used to perform en face scanning required for three dimensional OCT measurements. This scanning engine has an outer diameter of 0.9mm and a length of 9mm, and features custom fabricated 10 μm thick polyimide flexible interconnect lines ...

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    23. Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample to study the correlation between PS-OCT and SHG microscopy. Qualitative conjecture has been made that the phase retardation measured by PS-OCT is affected by the relationship between the collagen fiber ...

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    24. Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Ophthalmic diagnostic imaging using optical coherence tomography (OCT) is limited by bulk eye motions and a fundamental trade-off between field-of-view (FOV) and sampling density. Here, we introduced a novel multi-volumetric registration and mosaicking method using our previously described multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) system. Our SS-SESLO-OCT acquires an entire en face fundus SESLO image simultaneously with every OCT cross-section at 200 frames-per-second. In vivo human retinal imaging was performed in a healthy volunteer, and three volumetric datasets were acquired with the volunteer moving freely and refixating between each acquisition. In post-processing, SESLO frames were used ...

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