1. All Articles

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    1. Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies

      Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies

      The use of optical coherence tomography to diagnose conditions that predominantly affect the photoreceptor layer is postulated as a technique that allows to evaluate the relationship between retinal changes and loss of visual acuity. Two clinical cases are presented on patients with a bilateral decrease of their visual acuity and alteration in chromatic perception. Optical coherence tomography revealed subfoveal focal hypo-reflective defects on the hyper-reflective band (known as the ellipsoid zone).

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    2. Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players

      Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players

      The main hypothesis is that exposure to repeated shocks is associated with a greater decrease in the thickness of optical nerve fibres. In order to show a association between the occurrence of concussions (in number and severity) and the variation in the thickness of the retinal nerve fibre layer, all participating rugby players will have an ophthalmologic examination (OCT and (retinophotography) at the beginning and end of the Rugby season.

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    3. Research Scientist for Optical Diagnostic at Carestream Dental

      Research Scientist for Optical Diagnostic at Carestream Dental

      We are seeking a Research Scientist for Optical Diagnostics to be part of an innovative research team that develops new optical devices for improving measurements and diagnoses in dentistry. Position Description: Research Scientist who will research and develop new optical technologies for dental measurements and diagnostics Conceptualize and demonstrate new applications of optics and photonics in solving problems in modern dentistry and advancing the field Design, implement, and develop experimental and protype systems and perform clinical evaluation Collaborate with a multi-disciplinary team to translate technology solution into commercial product H-1B Candidates are welcome to apply Requirements Required Skills and Experience ...

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    4. Apelin as a Potential Treatment for Chronic Kidney Disease

      Apelin as a Potential Treatment for Chronic Kidney Disease

      Chronic kidney disease (CKD) affects 8-16% of the world's population, and is independently associated with cardiovascular disease (CVD). As renal function declines, rates of major adverse cardiovascular events, cardiovascular and all-cause mortality increase. In addition to hypertension, increased arterial stiffness is characteristic of CKD, a marker of CVD risk, and an independent predictor of mortality in CKD patients. The endothelium is an important regulator of arterial stiffness, and endothelial dysfunction is a feature of CKD and a predictor of CVD. Current treatment of CKD is limited and aims to reduce blood pressure and proteinuria through the use of angiotensin ...

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    5. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected in a subset ...

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    6. Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Purpose To evaluate optical coherence tomographic angiography (OCTA) findings on retinal microcirculation in hyperopic anisometropic amblyopia compared with fellow eyes and nonamblyopic control eyes. Methods A total of 40 pediatric patients with hyperopic anisometropic amblyopia and 57 control subjects were recruited, and 137 eyes (40 amblyopic, 40 fellow, and 57 control eyes) were evaluated. Data on best-corrected visual acuity (logMAR), axial length (mm), refractive error, and OCTA findings (foveal avascular zone parameters, macular vascular density in superficial and deep retinal capillary plexus, central macular thickness) were recorded in amblyopic, fellow, and control eyes. Results Compared with fellow and control eyes ...

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    7. Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes

      Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes

      Imaging choriocapillaris (CC) is a long-term challenge for commercial OCT angiography (OCTA) systems due to limited transverse resolution. Effects of transverse resolution on the visualization of a CC microvascular network are explored and demonstrated in this paper. We use three probe beams with sizes of ~1.12 mm, ~2.51 mm and ~3.50 mm at the pupil plane, which deliver an estimated transverse resolution at the retina of 17.5 µm, 8.8 µm and 7.0 µm, respectively, to investigate the ability of OCTA to resolve the CC capillary vessels. The complex optical microangiography algorithm is applied to ...

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    8. PhD Studentship Opening at The University of Liverpool

      PhD Studentship Opening at The University of Liverpool

      PhD studentship in the development of optical coherence tomography (OCT) and artificial intelligence (AI) for precisely and automatically measurement of the corneal power. Successful students will receive a studentship of tuition fees paid at the Home/EU rate for 3.5 years and a stipend of £15,009 per annum for 3.5 years. In addition, students will have access to a research support fund of £1,000 per annum for purchasing equipment, consumables and conference costs co-managed by the academic supervisor. The project is supported by the University of Liverpool Doctoral Network in Future Digital Health, which is directed ...

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    9. Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

      Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

      Purpose To describe swept source-OCT (SS-OCT) and swept source-OCT angiography (SS-OCTA) findings in eyes with posterior microphthalmos (PM). Methods Twelve eyes (six patients) with PM were evaluated using SS-OCT and SS-OCTA. Structural changes, subfoveal choroidal thickness (SFCT), and perifoveal capillary changes with qualitative and quantitative assessments were analyzed. Twenty eyes served as control group. Results SS-OCT findings included elevated retinal papillo-macular fold (75%), retinal pigment epithelium folds (83%), macular cystoid spaces (42%), subretinal fluid (17%), and increased visibility of posterior vitreous cortex and hyaloid (42%). Mean SFCT in PM and in control eyes were 430.33 ± 157.48 µm and ...

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    10. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Purpose To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE). Methods In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE + MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses of the macula was determined by OCTA (optical coherence tomography angiography, RTVue-XR, Optovue). The mean defect was determined by visual field examination (mode 30-2, Humphrey Field Analyzer). The duration of ...

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    11. Anterior Segment Optical Coherence Tomography Images in Microsporidial Keratoconjunctivitis

      Anterior Segment Optical Coherence Tomography Images in Microsporidial Keratoconjunctivitis

      Purpose: To describe the findings of anterior segment optical coherence tomography (AS-OCT) in patients with microsporidial keratoconjunctivitis . Methods: The observational study included 13 eyes from 13 patients. Slit-lamp photography and AS-OCT were performed using the Swept source OCT before corneal scraping . All cases were positive for Gram-chromotrope (modified trichrome) staining for Microsporidia spp. Results: Three significant AS-OCT findings were observed. First, hyperreflective dots were limited to the epithelial layers of the cornea, and second, there were no extensions into the stromal layer in all cases. Last, hyperreflective dots slightly raised above the epithelial surface were observed in most cases (12 ...

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    12. Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral positions immediately open at Boston University School of Medicine, Boston Medical Center. About the position : We are looking for highly motivated individuals to join the lab, to develop novel optical imaging techniques for ophthalmic and endoscopic applications. Candidates with experiences on ophthalmic imaging, endoscopy, optical coherence tomography, fiber sensing and imaging system will be highly competitive. The position will require PhD degree on scientific discipline, for example, electrical engineering, computer science, biomedical engineering etc. The position also requires good communication skill, willingness for collaboration, and is expected to independently publish scientific papers. Please contact the PI, Dr. Ji Yi ...

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    13. Role of Intracoronary Imaging in Plaque Identification

      Role of Intracoronary Imaging in Plaque Identification

      NSTE-ACS patients are more likely to exhibit high-risk plaque characteristics in non-culprit lesions. Both IVUS and OCT imaging techniques interact in a complementary manner to provide morphological characterization of the atherosclerotic coronary plaques and help identification of high-risk vulnerable plaques. Using morphological parameters obtained from OCT and IVUS, a new plaque vulnerability score will be established for more precise definition of the most vulnerable plaques that carry the greatest risk of rupture and subsequent detrimental clinical outcomes in the future. Such score might help in targeting these plaques with certain therapeutic interventions aiming to their stabilization.

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    14. Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Avinger, Inc. (AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of patients with Peripheral Artery Disease (PAD), today announced that physicians in 78 clinical sites have successfully treated more than 1,000 patients with the next-generation Pantheris image-guided atherectomy system. The next-generation Pantheris was launched on a limited basis in the U.S. following receipt of 510(k) clearance by the U.S. Food and Drug Administration (FDA) in late May 2018 and features a number of improvements intended to augment the performance and reliability of the product. Importantly ...

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      Mentions: FDA Avinger
    15. Progress in Multimodal En Face Imaging: feature introduction

      Progress in Multimodal En Face Imaging: feature introduction

      This feature issue contains papers that report on the most recent advances in the field of en face optical coherence tomography (OCT) and of combinations of modalities facilitated by the en face view. Hardware configurations for delivery of en face OCT images are described as well as specific signal and image processing techniques tailored to deliver relevant clinical diagnoses. The value of the en face perspective for enabling multimodality is illustrated by several combination modalities.

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    16. Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that ...

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      Mentions: Xincheng Yao
    17. Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients

      Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients

      Background To analyze the optical coherence tomography (OCT) characteristics and visual outcome of vitrectomy in myopic foveoschisis (MF) patients and identify prognostic factors. Methods This study is a retrospective clinical cohort study in tertiary care hospital. Thirty-two eyes of 32 patients who underwent MF-related vitrectomy in were investigated retrospectively. Best-corrected visual acuity (BCVA) measured at 1 year post surgery and changes in central foveal thickness (CFT) and co-existing macular pathologies, such as foveal detachment (FD), lamellar holes, and macular holes were the main outcome measures. Prognostic factors were identified using multivariate linear regression analysis. Results Average BCVA (in logarithm of ...

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    18. Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC) (OPACITY)

      Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC) (OPACITY)

      Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina. The investigating team used this approach in patients with acute, recurrent and persistent subtypes of Central Serous Chorioretinopathy (CSC) to check for possible Choriocapillaris hypoperfusion. The presence or absence of these microvascular changes was explored in both eyes of the patients and compared to a control group of healthy volunteers. The possibility of a correlation between Choriocapillaris flow deficits, age and spontaneous resolution of serous retinal detachment was also evaluated. This study was conducted in an effort to improve one ...

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    19. Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Ping An Insurance (Group) Company of China, Ltd. is pleased to announce that its technology arm, Ping An Technology, has completed a prospective multi-center clinical trial for the world's first intelligent optical coherence tomography (OCT) retinal disease screening system. The screening system is jointly developed by Ping An Technology and US-based Optovue, Inc. It is the first artificial intelligence (AI) imaging and screening system in the world that seamlessly integrates an OCT retinal imaging device and AI lesion detection software. The clinical trial was conducted at three well-known research institutions, the Eye and ENT Hospital of Fudan University in ...

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    20. Projection resolved optical coherence tomography angiography to distinguish flow signal in retinal angiomatous proliferation from flow artifact

      Projection resolved optical coherence tomography angiography to distinguish flow signal in retinal angiomatous proliferation from flow artifact

      Purpose To investigate whether hyperreflective foci (HRF) exhibit flow projection artifact on OCTA, and study the efficacy of commercial projection artifact removal software (PAR-OCTA, Optovue, Inc), and a custom projection resolved OCTA (PR-OCTA) in distinguishing artifacts from true flow in retinal angiomatous proliferation (RAP). Methods The study included five eyes with HRF representing pigment migration in dry age-related macular degeneration (AMD), five eyes with leaking treatment- naïve RAP, and ten eyes with diabetic hard exudates. We examined flow signal on OCTA cross-sections using PAR, and performed PR-OCTA to study the effect of increasingly stringent projection removal thresholds. Flow signal ...

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    21. Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma

      Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma

      Purpose To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images. Design Prospective, cross-sectional study. Methods Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain AS-OCTA images of the corneal limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The vessel density ...

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