1. All Articles

    1-24 of 15839 1 2 3 4 ... 658 659 660 »
    1. Research Engineer/Software Programmer Position at Doheny Eye Institute UCLA

      Research Engineer/Software Programmer Position at Doheny Eye Institute UCLA

      GOAL: Develop graphical user interface (GUI) tools in Windows and web-based applications. RESEARCH LABORATORY: Doheny Image Analysis Laboratory (DIAL) at Doheny Eye Institute/University of California, Los Angeles PROJECT DESCRIPTION: We are a rapidly growing and interdisciplinary group to investigate new approaches for image segmentation, registration, visualization, and analysis in various multimodal ophthalmic images at Doheny Eye Institute, standing among the top recipients of medical research grants from the National Institutes of Health, which fund 80% of all vision research in America. We are particularly interested in the development of graphical user interface tools for Windows and web-based applications including ...

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    2. Microscopic OCT imaging with focus extension by ultrahigh-speed acousto-optic tunable lens and stroboscopic illumination

      Microscopic OCT imaging with focus extension by ultrahigh-speed acousto-optic tunable lens and stroboscopic illumination

      We develop high-resolution optical coherence tomography (OCT) system with high-speed acousto-optic tunable lens. Stroboscopic pulsed illumination is used for the first time to perform time-resolved OCT imaging with acousto-optic tunable focusing. The operation of ultrahigh-speed tunable acousto-optic lens is demonstrated theoretically and experimentally. Focal position tuning at MHz frequency range is experimentally shown in the imaging system leading to OCT images with extended depth of focus. Imaging with active optical elements is helpful for improvement of photon collection efficiency, depth of focus and enhancement of the image quality.

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    3. The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina

      The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina

      Purpose: We developed a novel technique using a drug microperfusion device and time-lapse optical coherence tomography (OCT) for accelerated drug screening and retinotoxin characterization. Methods: Using an ex vivo rabbit eyecup preparation, we studied retinotoxin effects in real-time by microperfusing small retinal areas under a transparent fluoropolymer tube. Known retinotoxic agents were applied to the retina for 5 minute periods while changes in retinal structure, thickness, and reflectance were monitored with OCT. The OCT images of two agents with dissimilar mechanisms, cyanide and kainic acid, were compared with their structural changes seen histologically. Results: We found the actions of retinotoxic ...

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    4. Management of intrastromal glass foreign body based on anterior segment optical coherence tomography and Pentacam analysis

      Management of intrastromal glass foreign body based on anterior segment optical coherence tomography and Pentacam analysis

      We read with interest the article by Huda et al. [ 1 ] which reported the clinical aspects and the imaging of a patient with intrastromal glass foreign bodies after a road traffic accident using both anterior segment optical coherence tomography (AS-OCT) and ocular Pentacam, and “demonstrated that AS-OCT and ocular Pentacam are effective and necessary procedures for both the diagnosis and follow-up of intracorneal foreign bodies”. While this paper contributed to our understanding of how AS-OCT and ocular Pentacam may potentially affect the management protocol in these cases, there are relevant additions that we will like to highlight. We encountered a ...

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    5. Pulmonary vein stenosis after radiofrequency ablation: in vivo optical coherence tomography insights

      Pulmonary vein stenosis after radiofrequency ablation: in vivo optical coherence tomography insights

      A 56-year-old woman with paroxysmal atrial fibrillation refractory to medical treatment developed left inferior pulmonary vein (LIPV) stenosis 3 months after catheter ablation. Radiofrequency was delivered at the antrum of the vein, but some ostial applications were needed to achieve vein disconnection at the carina between both the left PV. She complained of cough and effort dyspnoea. Computed tomography angiography showed severe proximal stenosis in the LIPV, and percutaneous intervention for stent implantation was planned. Vein pulmonary angiography showed an ostial stenosis of the LIPV ( Panel A ). Optical coherence tomography (OCT) is an imaging technique that provides high-resolution (up to ...

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    6. Spectral Domain OCT Imaging Techniques in Tamoxifen Retinopathy

      Spectral Domain OCT Imaging Techniques in Tamoxifen Retinopathy

      Purpose: To highlight the use of high-density spectral domain optical coherence tomography (SD-OCT) in the detection of tamoxifen retinopathy. Case Report: An 82-year-old asymptomatic woman with a history of tamoxifen therapy for breast cancer was found to have bilateral refractile retinal deposits on fundus examination. Detection on SD-OCT was compared across imaging techniques. High-density SD-OCT demonstrated hyperreflective deposits in the inner retinal layers of each eye consistent with the diagnosis of tamoxifen retinopathy. Conclusions: The optimal SD-OCT scan technique depends on the ocular condition being imaged. High-density scan techniques require longer acquisition time but may enhance the detection of focal ...

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    7. Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold: OCT Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of

      Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold: OCT Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of

      Objectives This study sought to describe the frequency and clinical impact of acute scaffold disruption and late strut discontinuity of the second-generation Absorb bioresorbable polymeric vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, California) in the ABSORB (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) cohort B study by optical coherence tomography (OCT) post-procedure and at 6, 12, 24, and 36 months. Background Fully bioresorbable scaffolds are a novel approach to treatment for coronary narrowing that provides transient vessel support with drug delivery capability without ...

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    8. ARVO Imaging in the Eye Conference Denver Colorado, May 2, 2015

      ARVO Imaging in the Eye Conference Denver Colorado, May 2, 2015

      Join your colleagues for the ARVO Imaging Conference (formerly ISIE), Saturday, May 2, 2015 in Denver. This one-day conference takes place the day before the ARVO Annual Meeting. See more information by clicking HERE . The ARVO Imaging Conference is highly recommended by your peers as a valuable source of in-depth information on the newest techniques and technologies in imaging. “This conference pulls together all the various imaging modalities with all tissues and diseases. It provides not only an invaluable insight into new and state-of-the-art technology across the board, but it also introduces the participants into a bit of every exciting ...

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    9. Case Western Reserve University Posdoctoral Fellow Positions Open

      Case Western Reserve University Posdoctoral Fellow Positions Open

      The Jenkins lab at Case Western Reserve University (Deparments of Pediatrics and Biomedical Engineering) is looking for sharp, enthusiastic, well-trained individuals for postdoctoral fellow positions. Project opportunities include the development of optical pacing, optical inhibition (blocking action potential propagation), and optical imaging (e.g. OCT) technology for cardiovascular and neural applications. Applicants are expected to have earned a Ph.D. in biomedical engineering or a related field. Specific experience in building optical imaging systems or infrared stimulation is especially preferred, but the primary qualifications are outstanding technical proficiency and research skill. Successful applicants will be expected to work in an ...

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    10. Assessment of Coronary Plaque Composition Using Optical Coherence Tomography

      Assessment of Coronary Plaque Composition Using Optical Coherence Tomography

      The investigators hypothesis is that local activation of the endogenous Lp-PLA2 plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and mechanical properties that characterize plaque vulnerability. Thus, the investigators study will characterize prospectively the correlation between the functional and structural vascular wall properties, and the activity of the Lp-PLA2 pathway.

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    11. Motion Artefact Correction in Retinal Optical Coherence Tomography Using Local Symmetry

      Motion Artefact Correction in Retinal Optical Coherence Tomography Using Local Symmetry

      Patient movements during the acquisition of SD-OCT scans create substantial motion artefacts in the volumetric data that hinder registration and 3D analysis and can be mistaken for pathologies. In this paper we propose a method to correct these artefacts using a single volume scan while still retaining the overall shape of the retina. The method was quantitatively validated using a set of synthetic SD-OCT volumes and qualitatively by a group of trained OCT grading experts on 100 SD-OCT scans. Furthermore, we compared the motion compensation estimation by the proposed method with a hardware eye tracker on 100 SD-OCT volumes.

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    12. Quantitative Optical Coherence Tomography Analysis for Late In-Stent Restenotic Lesions

      Quantitative Optical Coherence Tomography Analysis for Late In-Stent Restenotic Lesions

      Coronary optical coherence tomography (OCT) has the potential to identify in-stent neoatherosclerosis, which is a possible risk factor for late acute coronary events after drug-eluting stent implantation. The purpose of this study was to investigate differences between mid-term and late in-stent restenosis after stent implantation by quantitative and semiautomated tissue property analysis using OCT. In total, 1063 OCT image frames of 16 lesions in 15 patients were analyzed. This included 346 frames of 6 lesions in late in-stent restenosis, which was defined as restenosis that was not detected at 6 to 12 months but ≥ 12 months after follow-up coronary angiography ...

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    13. In vivo imaging of human vasculature in the chorioretinal complex using phase-variance contrast method with phase-stabilized 1-μm swept-source optical coherence tomography

      In vivo imaging of human vasculature in the chorioretinal complex using phase-variance contrast method with phase-stabilized 1-μm swept-source optical coherence tomography

      We present a noninvasive phase-variance (pv)–based motion contrast method for depth-resolved imaging of the human chorioretinal complex microcirculation with a newly developed phase-stabilized high speed (100-kHz A-scans/s) 1 - μ m swept-source optical coherence tomography (SSOCT) system. Compared to our previous spectral-domain (spectrometer based) pv-spectral domain OCT (SDOCT) system, this system has the advantages of higher sensitivity, reduced fringe wash-out for high blood flow speeds and deeper penetration in choroid. High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. This process does not require additional calibration hardware and complex numerical procedures. Our phase stabilization ...

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    14. Test-Retest Variability of Retinal Nerve Fiber Layer Thickness and Macular Ganglion Cell-Inner Plexiform Layer Thickness Measurements Using Spectral-Domain Optical Coherence Tomography

      Test-Retest Variability of Retinal Nerve Fiber Layer Thickness and Macular Ganglion Cell-Inner Plexiform Layer Thickness Measurements Using Spectral-Domain Optical Coherence Tomography

      Purpose: To evaluate the test-retest variability of spectral-domain optical coherence tomography (OCT) in measurement of retinal nerve fiber layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness. Methods: A total of 65 eyes of healthy subjects were enrolled in this observational cross-sectional study. RNFL thickness and GCIPL thickness were measured using the repeat scan optic cube and macular cube protocol using Cirrus HD-OCT (software version 6.0). A single operator obtained 3 measurements during 1 session to determine test-retest variability. Intrasession repeatability was defined by intraclass correlation, limits of agreement, and coefficient of variation. Results: The mean age ...

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    15. Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions

      Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions

      The statistical model of scattered by flowing Brownian particles coherent radiation is suggested. The model includes the random Doppler shifts caused by particle Brownian motion and the speckle fluctuations caused primarily by the flow motion of particles. Analytical expressions are obtained for the correlation function, power spectrum, and spectral width of scattered radiation in the imaging geometry typically used in optical coherence tomography (OCT). It is shown that the spectral density has the Voigt shape, a well-known spectral profile from atomic and molecular spectroscopy. The approach enables the choice of the experimental regimes for the measurement of Brownian particle motion ...

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    16. Law Firm Launches Investigation of the Board of Directors of Volcano Corporation Regarding the Fairness of the Sale of the Company to Royal Philips

      Law Firm Launches Investigation of the Board of Directors of Volcano Corporation Regarding the Fairness of the Sale of the Company to Royal Philips

      Levi & Korsinsky is investigating the Board of Directors of Volcano Corporation ("Volcano" or "the Company") (Nasdaq: VOLC ) for possible breaches of fiduciary duty and other violations of state law in connection with the sale of the Company to Royal Philips . Click here to learn more about the investigation: http://zlk.9nl.com/volcano-volc . Under the terms of the transaction, Volcano shareholders will receive $18.00 in cash for each share of Volcano stock they own. The investigation concerns whether the Board of Volcano breached their fiduciary duties to stockholders by failing to adequately shop the Company before agreeing to enter ...

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    17. Optically buffered Jones-matrix-based multifunctional optical coherence tomography with polarization mode dispersion correction

      Optically buffered Jones-matrix-based multifunctional optical coherence tomography with polarization mode dispersion correction

      Polarization mode dispersion (PMD) degrades the performance of Jones-matrix-based polarization-sensitive multifunctional optical coherence tomography (JM-OCT). The problem is specially acute for optically buffered JM-OCT, because the long fiber in the optical buffering module induces a large amount of PMD. This paper aims at presenting a method to correct the effect of PMD in JM-OCT. We first mathematically model the PMD in JM-OCT and then derive a method to correct the PMD. This method is a combination of simple hardware modification and subsequent software correction. The hardware modification is introduction of two polarizers which transform the PMD into global complex modulation ...

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    18. USC Eye Institute Adds 12 Faculty Physician Scientists in 2014

      USC Eye Institute Adds 12 Faculty Physician Scientists in 2014

      The University of Southern California (USC) Eye Institute has recruited 12 physician scientists from some of the world’s leading institutions, specializing in the diagnosis and treatment of a wide spectrum of vision disorders. The recruitment is part of an overarching growth strategy that anticipates increased demand in eye care services. According to the National Eye Institute, more than 65 percent of Americans 40 years or older suffer from some sort of vision impairment – ranging from near- or far-sightedness to blindness. That number is expected to swell as the population ages. Each physician recruit contributes expertise in a unique area ...

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    19. Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes

      Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes

      Purpose To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. Methods Corneal measurements of 110 normal eyes (one eye per subject) and 70 keratoconic eyes were obtained from both devices and compared. Agreement was determined using the Bland–Altman analysis 95% limits of agreement (LoA). Results The Pentacam measured significantly greater keratometry readings in the flattest (K1) and steepest meridians (K2) in normal and keratoconic eyes. The 95% LoA in normal eyes were −0.32 to 0.59 ...

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    20. Multimodality imaging of attenuated plaque using grayscale and virtual histology intravascular ultrasound and optical coherent tomography

      Multimodality imaging of attenuated plaque using grayscale and virtual histology intravascular ultrasound and optical coherent tomography

      Background Although attenuated plaque is a marker for plaque vulnerability, the quantification and its implication have not been known. Methods Multimodality pre-procedural imaging using grayscale intravascular ultrasound (IVUS), virtual histology-IVUS (VH-IVUS) and optical coherence tomography (OCT) were performed in 115 coronary lesions with diameter stenosis (DS) >30% and plaque burden ≥50% and compared the diagnostic accuracies for detecting thin-cap fibroatheromas (TCFA). Results A maximal arc of attenuation (40MHz IVUS) ≥29.0° was the cut-off for predicting VH-TCFA (sensitivity 74%, specificity 66%); and OCT-TCFA (sensitivity 89%, specificity 64%), while a maximal arc attenuation≥29.0° (20MHz IVUS) showed a poor sensitivity ...

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    21. Philips to acquire Volcano to expand global leadership position in image-guided therapy market

      Philips to acquire Volcano to expand global leadership position in image-guided therapy market

      Royal Philips (NYSE: PHG; AEX: PHIA) and Volcano Corporation (NASDAQ:VOLC), a global leader in catheter-based imaging and measurement solutions for cardiovascular applications, today announced that they have entered into a definitive merger agreement. Pursuant to the agreement, Philips will commence a tender offer to acquire all of the issued and outstanding shares of Volcano for USD 18.00 per share, or a total equity purchase price of USD 1 billion (approx. EUR 800 million), to be paid in cash upon completion. The board of directors of Volcano has unanimously approved the transaction and recommends the offer to its shareholders ...

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    22. MEMS scanning micromirror for optical coherence tomography

      MEMS scanning micromirror for optical coherence tomography

      This paper describes an endoscopic-inspired imaging system employing a micro-electromechanical system (MEMS) micromirror scanner to achieve beam scanning for optical coherence tomography (OCT) imaging. Miniaturization of a scanning mirror using MEMS technology can allow a fully functional imaging probe to be contained in a package sufficiently small for utilization in a working channel of a standard gastroesophageal endoscope. This work employs advanced image processing techniques to enhance the images acquired using the MEMS scanner to correct non-idealities in mirror performance. The experimental results demonstrate the effectiveness of the proposed technique.

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    1-24 of 15839 1 2 3 4 ... 658 659 660 »
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