1. All Articles

    1-24 of 18523 1 2 3 4 ... 770 771 772 »
    1. A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”)

      A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”)

      Purpose The purpose was to illustrate small melanocytic choroidal tumors with speckle-noise free swept-source optical coherence tomography (SSOCT). Methods Twenty-five small melanocytic choroidal tumors in 24 eyes underwent 1050 nm OCT. All tumors were measured manually with the built-in caliper tool and compared to data derived from a semiautomated algorithm that removed speckle noise but preserved the structure of the tumors from the SSOCT data. Results The average manual measurements for the horizontal, vertical, and axial diameters were 1535.28 μm (range, 547–2807 μm), 1713.8 μm (range, 574–3921 μm), and 227.28 μm (range, 115–489 μm ...

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    2. Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Purpose To compare subfoveal choroidal thickness (GCSF) in patients with diabetic macular oedema (DMO) and healthy subjects using swept source optical coherence tomography (SS-OCT). Method Cross-sectional study including 50 eyes of 36 patients with DMO, and 47 eyes of 34 patients as a control group. GCSF was measured in both groups, analysing between the eyes with DMO according to the type of oedema (predominantly cystic or diffuse). Results The study groups were homogeneous in terms of mean age (63.4 years for DMO and 62.65 years for controls; P =.36) and the mean axial length (23.21 mm for ...

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    3. Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa

      Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa

      Purpose To assess relationships between structural and functional biomarkers, including new topographic measures of visual field sensitivity, in patients with autosomal dominant retinitis pigmentosa. Methods Spectral domain optical coherence tomography line scans and hill of vision (HOV) sensitivity surfaces from full-field standard automated perimetry were semi-automatically aligned for 60 eyes of 35 patients. Structural biomarkers were extracted from outer retina b-scans along horizontal and vertical midlines. Functional biomarkers were extracted from local sensitivity profiles along the b-scans and from the full visual field. These included topographic measures of functional transition such as the contour of most rapid sensitivity decline around ...

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    4. Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Purpose To describe the use of a novel intra-ocular side-scanning probe enabling the acquisition of spectral-domain optical coherence tomography (SD-OCT) images during surgery in a series of patients with complex forms of retinal detachment. Methods A 23-gauge, side-scanning SD-OCT probe (C7 System; LightLab Imaging, Inc/St Jude Medical, St. Paul, MN, USA) in a 20-gauge catheter, was used to acquire the intra-operative OCT images in seven patients with vitreoretinal diseases. Twenty-five gauge pars plana vitrectomy (PPV) was performed in every patient in a standard fashion. After enlarging the temporal sclerotomy to a 20-gauge port, all the patients were scanned with ...

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    5. Examining the past

      Examining the past

      Greetings! Today I thought I’d dip into the technology file and have a look at some research into new techniques developed to examine our artifacts. A painting in a museum tells us one story but what lies beneath its surface may tell quite another. Most great masterpieces are covered with varnish, sometimes several coats applied at different times over their history. The varnish was originally applied to protect the paint underneath and make the colors more vivid, but over the centuries it can degrade. Conservators carefully clean off the old varnish and replace it with new, but to do ...

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    6. Segmentation Errors in Macular Ganglion Cell Analysis as Determined by Optical Coherence Tomography

      Segmentation Errors in Macular Ganglion Cell Analysis as Determined by Optical Coherence Tomography

      Purpose To investigate the prevalence, features, associated factors, and reproducibility of segmentation errors in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement as determined by optical coherence tomography (OCT). Design Cross-sectional study. Participants Five hundred thirty-eight glaucomatous and healthy eyes from 290 subjects with OCT-measured macular GCIPL thickness were enrolled. Eyes with macular disorders, including epiretinal membrane, macular degeneration, macular hole, and myopic maculopathy, were excluded. Methods By inspecting 128 cross-sectional OCT B-scan images per eye, the presence (yes vs. no), layer (anterior vs. posterior border), location (quadrants), and area (diffuse vs. focal) of macular GCIPL segmentation error were ...

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    7. Macular Changes Following Strabismus Surgery Confirmed by the Use of Optical Coherence Tomography

      Macular Changes Following Strabismus Surgery Confirmed by the Use of Optical Coherence Tomography

      Although temporary changes in corneal curvature following strabismus surgery have been described, there has been little known about macular changes occurring as well. Optical coherence tomography (OCT) can detect even subclinical postoperative changes. In this issue, Mintz et al. have documented subclinical increases in the foveal and perifoveal macular thickness following strabismus surgery using OCT. The etiology of these OCT findings is currently unclear. Perhaps, as expressed by the authors, it might be due to changes in the mechanical forces or postoperative inflammation and changes in the blood–retinal barrier. The macular thickness changes following strabismus surgery were relatively small ...

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    8. Macular Thickness Following Strabismus Surgery as Determined by Optical Coherence Tomography

      Macular Thickness Following Strabismus Surgery as Determined by Optical Coherence Tomography

      PURPOSE: To investigate macular changes following strabismus surgery by using optical coherence tomography (OCT). METHODS: The authors prospectively evaluated 60 eyes of 30 patients undergoing unilateral extraocular muscle surgery. OCT measurements employing the fast macular thickness mapping protocol were performed 1 day prior to surgery and 1 day postoperatively. Postoperative macular changes in the study eye that was operated on (n = 30) were compared with the fellow control eye (n = 30, controls). RESULTS: There was an increase in mean ± standard deviation central foveal thickness (CFT) in the operated eyes, from 201.63 ± 18.36 µm at baseline to 206.03 ...

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    9. Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

      Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

      Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the guinea pig cochlear apex in two directions with minimal surgery ...

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    10. Optovue Releases AngioAnalytics, World's First OCTA Blood Vessel Measurement Technology

      Optovue Releases AngioAnalytics, World's First OCTA Blood Vessel Measurement Technology

      Optovue , the global leader in the development and commercialization of optical coherence tomography angiography (OCTA), today announced commercial availability of AngioAnalytics™*, the next generation of its OCTA technology available on the AngioVue™ ** Imaging System, for use outside of the U.S. This new capability enables clinicians to quantify the density of blood flow in the retina, the light-sensitive portion of the eye, to help manage diseases that cause progressive blindness such as diabetic retinopathy or acute macular degeneration. Optovue also announced it will host an educational symposium at the World Ophthalmology Congress ( WOC 2016 ) entitled, "The Transformative Power of Quantitative ...

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    11. OCT: advances in primary eye care

      OCT: advances in primary eye care

      With the increasing use of the optical coherence tomography in primary eye care practices, it is perhaps not surprising that an annual conference dedicated to this area is becoming established. The Topcon University-supported National OCT Conference attracted speakers and delegates from the UK and beyond. Over 22-23 November, the conference covered a range of topics from ocular pathology to business modelling in clinical practice, and also offered a clue as to future developments in OCT technology. Here we summarise the key learning points that emerged. OCT Evolution Professor Paulo Stanga (Manchester), who was instrumental in introducing OCT to UK clinical ...

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    12. Correction of aberrations in digital holography using the phase gradient autofocus technique

      Correction of aberrations in digital holography using the phase gradient autofocus technique

      We propose a method for correcting aberrations in digital holography based on the principles of computational adaptive optics using the phase gradient autofocus technique that demands no reference measurements. The method requires a priori information on the relative positions of the elements of the optical setup. It is applicable for sufficiently smooth optical aberrations. This technique does not impose any restrictions on the magnitude of the scattered optical field phase distortions caused by the object structure. The efficacy of the proposed method is demonstrated through numerical simulation and experimental verification.

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    13. Automated Early Detection of Glaucoma in Wavelet Domain Using Optical Coherence Tomography Images

      Automated Early Detection of Glaucoma in Wavelet Domain Using Optical Coherence Tomography Images

      Glaucoma is a chronic eye disease now-a-days that leads to visual impairment and blindness worldwide. Neurodegeneration of the optic nerve in association with changes in the parapapillary region induces glaucoma. Hence, the premature detection of optic nerve damage may permit early detection of glaucoma. In this paper, an image classification system is developed for early stage glaucoma diagnosis based on Discrete Wavelet Transform (DWT) using Optical Coherence Tomography (OCT) images. After DWT decomposition, significant wavelet coefficients are selected using t-test class separability criteria and fed into the Support Vector Machine (SVM) classifier for automated diagnosis. The proposed approach effectively classifies ...

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    14. Use of intravascular ultrasound vs. optical coherence tomography for mechanism and patterns of in-stent restenosis among bare metal stents and drug eluting stents

      Use of intravascular ultrasound vs. optical coherence tomography for mechanism and patterns of in-stent restenosis among bare metal stents and drug eluting stents

      This article is a perspective responses to the “Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents” by Goto et al ., The above mentioned article outlines the use of intravascular ultrasound (IVUS) in visualizing the patterns and mechanisms of in-stent restenosis (ISR) post percutaneous coronary intervention (PCI). Although IVUS is an appropriate method of choice for this scenario, IVUS has certain limitations which can be overcome by using optical coherent tomography (OCT). OCT is not only able to overcome IVUS’s limitations but is also able to provide additional information to ...

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    15. Optical Coherence Tomography in Very Late DES Thrombosis

      Optical Coherence Tomography in Very Late DES Thrombosis

      Study Questions: What are the mechanisms underlying very late stent thrombosis (VLST), as assessed by optical coherence tomography (OCT) in patients treated with early- and newer-generation drug-eluting stents (DES)? Methods: Between August 2010 and December 2014, 64 patients were investigated at the time-point of VLST as part of an international OCT registry. OCT pullbacks were performed after restoration of flow and analyzed at 0.4 mm. A total of 38 early- and 20 newer-generation DES were suitable for analysis. The investigators reported frame-level, segment-level, and stent-level analyses. Results: VLST occurred at a median time of 4.7 years (interquartile range ...

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    16. Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study

      Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study

      Background Many glaucoma referrals from the community to hospital eye services are unnecessary. Imaging technologies can potentially be useful to triage this population. Objectives To assess the diagnostic performance and cost-effectiveness of imaging technologies as triage tests for identifying people with glaucoma. Design Within-patient comparative diagnostic accuracy study. Markov economic model comparing the cost-effectiveness of a triage test with usual care. Setting Secondary care. Participants Adults referred from the community to hospital eye services for possible glaucoma. Interventions Heidelberg Retinal Tomography (HRT), including two diagnostic algorithms, glaucoma probability score (HRT-GPS) and Moorfields regression analysis (HRT-MRA); scanning laser polarimetry [glaucoma diagnostics ...

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    17. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Employer Description Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. Led by Guillermo ...

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    18. Optical Coherence Tomography Angiography of Choroidal Neovascularization Associated with Tuberculous Serpiginous-like Choroiditis

      Optical Coherence Tomography Angiography of Choroidal Neovascularization Associated with Tuberculous Serpiginous-like Choroiditis

      Choroidal neovascularization secondary to tuberculous serpiginous-like choroiditis (Tb-SLC) is uncommon and requires further invasive imaging, such as fluorescein and indocyanine green angiography. We evaluate the optical coherence tomography angiography (OCTA) findings in a patient with a Tb-SLC and present the use of this investigation as a non-invasive diagnostic and follow-up clinical tool in this disease.

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    19. Optical coherence tomography angiography characteristics of polypoidal choroidal vasculopathy

      Optical coherence tomography angiography characteristics of polypoidal choroidal vasculopathy

      Purpose To analyse the morphological characteristics of polypoidal choroidal vasculopathy (PCV) on optical coherence tomography angiography (OCT-A). Methods Prospective study with consecutive patients affected with PCV were included. All patients underwent a complete ophthalmological examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. Results Twelve eyes of 12 patients (mean age 72.6±10.5 years; 4 men and 8 women) were included for analysis. In all eyes (12/12) the segmentation of the choriocapillaris layer on OCT-A revealed the branching vascular network (BVN) as a hyperflow lesion. OCT-A segmentation of the choriocapillaris layer in correspondence ...

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    20. Systems and methods for sub-aperture based aberration measurement and correction in interferometric imaging

      Systems and methods for sub-aperture based aberration measurement and correction in interferometric imaging

      Systems and methods for sub-aperture correlation based wavefront measurement in a thick sample and correction as a post processing technique for interferometric imaging to achieve near diffraction limited resolution are described. Theory, simulation and experimental results are presented for the case of full field interference microscopy. The inventive technique can be applied to any coherent interferometric imaging technique and does not require knowledge of any system parameters. In one embodiment of the present invention, a fast and simple way to correct for defocus aberration is described. A variety of applications for the inventive method are presented.

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    21. Optical coherence tomography system having real-time artifact and saturation correction

      Optical coherence tomography system having real-time artifact and saturation correction

      An optical coherence tomography system having real-time artifact and saturation correction includes an optical coherence tomography unit, and a signal processing and display system adapted to communicate with the optical coherence tomography unit to receive imaging signals therefrom. The optical coherence tomography system is a Fourier Domain optical coherence tomography system. The signal processing and display system includes a parallel processor configured to correct the imaging signals, in real time, to at least partially remove image artifacts and saturation based on a subset of image data within an image frame.

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    22. Apparatus and method for generating tomography image

      Apparatus and method for generating tomography image

      A method of generating a tomography image includes performing a depth scan on one spot on a surface of a subject using modulated light received from a spatial light modulator, obtaining depth scan data for each of a plurality of patterns of the spatial light modulator by repeating the depth scan on the spot for each of the plurality of patterns, forming a matrix R representing a vector space based on a correlation of signal values of the depth scan data for each of the plurality of patterns, performing a matrix decomposition on the matrix R, dividing the vector space ...

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    23. ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY

      ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY

      Purpose: To describe changes in three-dimensional choroidal volume and thickness with full raster scans of enhanced depth imaging optical coherence tomography in patients with birdshot retinochoroidopathy. Methods: This prospective case series collected spectral domain optical coherence tomography images with the enhanced depth imaging technique from eight eyes of eight patients with birdshot retinochoroidopathy including four active patients (four eyes) and four quiet patients (four eyes). Fifty scans of each patient were manually segmented before automated built-in calibration software was used. Results: Of all active patients, there were no statistically significant differences in the total choroidal volume and mean central choroidal ...

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