1. All Articles

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    1. Self-sweeping laser could dramatically shrink 3-D mapping systems

      Self-sweeping laser could dramatically shrink 3-D mapping systems

      A new approach that uses light to move mirrors could usher in a new generation of laser technology for a wide range of applications, including remote sensing, self-driving car navigation and 3D biomedical imaging. A team of University of California, Berkeley, engineers led by Connie Chang-Hasnain, a professor of electrical engineering and computer sciences, used a novel concept to automate the way a light source changes its wavelength as it sweeps the surrounding landscape. They report their findings in the journal Scientific Reports , to be published Thursday, Sept. 3. The advance could have implications for imaging technology using LIDAR, or ...

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    2. Laser optomechanics

      Laser optomechanics

      Cavity optomechanics explores the interaction between optical field and mechanical motion. So far, this interaction has relied on the detuning between a passive optical resonator and an external pump laser. Here, we report a new scheme with mutual coupling between a mechanical oscillator supporting the mirror of a laser and the optical field generated by the laser itself. The optically active cavity greatly enhances the light-matter energy transfer. In this work, we use an electrically-pumped vertical-cavity surface-emitting laser (VCSEL) with an ultra-light-weight (130 pg) high-contrast-grating (HCG) mirror, whose reflectivity spectrum is designed to facilitate strong optomechanical coupling, to demonstrate optomechanically-induced ...

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    3. Optical Coherence Tomography for nanoparticles quantitative characterization

      Optical Coherence Tomography for nanoparticles quantitative characterization

      The unique features of nanocomposite materials depend on the type and size of nanoparticles, as well as their placement in the composite matrices. Therefore the nanocomposites manufacturing process requires inline control over certain parameters of nanoparticles such as dispersion and concentration. Keeping track of nanoparticles parameters inside a matrix is currently a difficult task due to lack of a fast, reliable and cost effective way of measurement that can be used for large volume samples. For this purpose the Optical Coherence Tomography (OCT) has been used. OCT is an optical measurement method, which is a non-destructive and non-invasive technique. It ...

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    4. Effect of Refractive Status and Axial Length on Peripapillary Retinal Nerve Fibre Layer Thickness: An Analysis Using 3D OCT

      Effect of Refractive Status and Axial Length on Peripapillary Retinal Nerve Fibre Layer Thickness: An Analysis Using 3D OCT

      Background: Accurate measurement of retinal nerve fiber layer (RNFL) is now possible with the high resolution optical coherence tomography (OCT). Effect of refractive status of the eye on RNFL thickness may be relevant in the diagnosis of glaucoma and other optic nerve diseases. Aim: To assess the RNFL thickness and compare its correlation with refractive status and axial length of the eye. Material and Methods: Three hundred eyes of 150 patients were included in this study, who underwent RNFL analysis using TOPCON 3D OCT 2000. Analysis of variance has been used to find the significance of study parameters between the ...

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    5. Detection of subsurface defects and measurement of thickness of screen layers made of graphene and carbon nanotubes with application of full-field optical coherence tomography in Linnik configuration

      Detection of subsurface defects and measurement of thickness of screen layers made of graphene and carbon nanotubes with application of full-field optical coherence tomography in Linnik configuration

      Optical coherence tomography (OCT) is noncontact and nondestructive interferometric method which allows visualization of internal structure of an investigated sample. Till now it has found many applications in measurements of biological tissues, technical materials and conservation of art. Optical coherence tomography in full-field configuration is a great technique for visualization of subsurface structures of measured sample with high resolution. In this technique, en-face data acquisition is applied, which allows application of microscope objectives with high numerical aperture while the depth of field is not a problem. These objectives allow obtaining ultra high transverse resolution like in traditional microscopy. Additionally, light ...

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    6. Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

      Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

      Importance Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography. Observations Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both ...

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    7. High-definition optical coherence tomography – an aid to clinical practice and research in dermatology

      High-definition optical coherence tomography – an aid to clinical practice and research in dermatology

      At present, beyond clinical assessment, the diagnosis of skin diseases is primarily made histologically. However, skin biopsies have many disadvantages, including pain, scarring, risk of infection, and sampling error. With recent advances in skin imaging technology, the clinical use of imaging methods for the practical management of skin diseases has become an option. The in vivo high-definition optical coherence tomography (HD-OCT) has recently been developed and commercialized (Skintell®; Agfa, Belgium). Compared with conventional OCT, it has a higher resolution; compared with reflectance confocal microscopy, it has a shorter time for image acquisition as well as a greater penetration depth and ...

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    8. THINKING LEAN: Improving Vitreoretinal Clinic Efficiency by Decentralizing Optical Coherence Tomography

      THINKING LEAN: Improving Vitreoretinal Clinic Efficiency by Decentralizing Optical Coherence Tomography

      Purpose: Patients in vitreoretinal clinic have long wait times that could be reduced by improving the efficiency of patient flow. The objective of this study was to determine whether decentralizing optical coherence tomography (OCT) into the technicians' room would reduce patient wait times and improve clinic efficiency. Methods: Randomized, single-center, clinical trial for 1 month without follow-up at Byers Eye Institute at Stanford. Subjects were return patients of three vitreoretinal specialists in March 2013. The intervention consisted of decentralizing OCT devices from the central photography suite into the technician screening rooms. Total clinic times and total wait times throughout subject ...

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    9. Relationships Between Indices of Retinal Thinning as Revealed by Spectral Domain Optical Coherence Tomography, and Visual and Cognitive Impairments in Schizophrenia

      Relationships Between Indices of Retinal Thinning as Revealed by Spectral Domain Optical Coherence Tomography, and Visual and Cognitive Impairments in Schizophrenia

      Schizophrenia is a neuropsychiatric disorder in which visual processing abnormalities are common. An unanswered question in this field is the extent to which some of these functional impairments (e.g., contrast sensitivity) may be due to altered retinal structure and function. This question has gained in importance with two recent studies showing retinal nerve fiber layer (RNFL) thinning in schizophrenia, as revealed by spectral domain optical coherence tomography (SD-OCT). OCT is a noncontact imaging technology that can image retinal structure (including thickness) in vivo with a resolution of 10 microns or less using optical backscattering of light. It has been ...

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      Mentions: Richard B. Rosen
    10. Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography

      Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography

      Purpose : The purpose of this study is to demonstrate three-dimensional (3D) graphing based on optical coherence tomography (OCT) angiography for characterization of the inner retinal vascular architecture and determination of its topologic principles. Methods : Rat eyes ( N = 3) were imaged with a 1300-nm spectral/Fourier domain OCT microscope. A topologic model of the inner retinal vascular network was obtained from OCT angiography data using a combination of automated and manually-guided image processing techniques. Using a resistive network model, with experimentally-quantified flow in major retinal vessels near the optic nerve head as boundary conditions, theoretical changes in the distribution of flow ...

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    11. Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes

      Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes

      Purpose : To study lamina cribrosa (LC) depth variation measured by spectral-domain optical coherence tomography (SD-OCT) in four glaucomatous optic disc phenotypes. Methods : In this cross-sectional study, 59 normal eyes and 180 open-angle glaucoma (OAG) eyes were grouped into 56 focally injured discs (FI), 30 generalized enlargement of the optic cup discs (GE), 69 myopic glaucomatous discs (MY), and 25 senile sclerotic discs (SS). They were imaged by enhanced depth imaging SD-OCT, obtaining multiple horizontal and vertical optic disc B-scans. Mean and maximum LC depths were measured relative to Bruch's membrane opening (BMO) and the anterior sclera (AS) reference planes ...

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      Mentions: Masanori Hangai
    12. New cataract and refractive imaging platform to be unveiled by Heidelberg Engineering at European Society of Cataract and Refractive Surgery

      New cataract and refractive imaging platform to be unveiled by Heidelberg Engineering at European Society of Cataract and Refractive Surgery

      Heidelberg Engineering will offer a preview of its cataract and refractive imaging platform* during this year’s Congress of the European Society of Cataract and Refractive Surgery (ESCRS) in Barcelona. The platform is based on an upgradable, modular design, which allows configuration to each product to the specific diagnostic workflow in a practice or clinic. Main options include: IOL biometry, corneal topography/tomography, anterior segment biometry and anterior segment imaging. The new platform is based on swept-source OCT technology. An important characteristic of the new platform is the fact that all measurements and analysis are based on high-resolution diagnostic images ...

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    13. Anterior Segment Optical Coherence Tomography Assessment After Laser Capsulotomy in Pseudophakic Eyes With Pseudoexfoliation

      Anterior Segment Optical Coherence Tomography Assessment After Laser Capsulotomy in Pseudophakic Eyes With Pseudoexfoliation

      Purpose: To assess changes in anterior-chamber depth (ACD) and angle width after neodymium:yttrium aluminum garnet (Nd:YAG) laser capsulotomy pseudophakia in eyes with pseudoexfoliation (PEX). Methods: This prospective and interventional case series study included 25 pseudophakic eyes of 25 patients with PEX and 26 pseudophakic eyes of 26 patients without PEX scheduled for Nd:YAG laser capsulotomy in a single institution. Anterior-chamber depth and angle width were measured with anterior segment optical coherence tomography before and three days after Nd:YAG laser capsulotomy. Preoperative and postoperative measurements of ACD and angle width included the angle opening distance (AOD), measured ...

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    14. The correlation between visual acuity outcomes and optical coherence tomography parameters following surgery for diabetic epiretinal membrane and taut posterior hyaloid

      The correlation between visual acuity outcomes and optical coherence tomography parameters following surgery for diabetic epiretinal membrane and taut posterior hyaloid

      Purpose: To evaluate the relationship between visual outcomes and the determinants detected by spectral domain optical coherence tomography (OCT) in eyes with epiretinal membrane (ERM) and/or taut posterior hyaloid (TPH) that underwent pars plana vitrectomy (PPV). Materials and methods: A total of 30 participants with diabetic ERM and TPH were included in the study. All study participants underwent PPV. Preoperative and postoperative best corrected visual acuity (BCVA), peripapillary retinal nerve fiber layer (RNFL), macular RNFL, ganglion cell layer, inner plexiform layer, and ganglion cell complex thicknesses were measured in each participant. Linear regression analyses were performed to determine the ...

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    15. Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy

      Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy

      We achieved human retinal imaging using visible-light optical coherence tomography (vis-OCT) guided by an integrated scanning laser ophthalmoscopy (SLO). We adapted a spectral domain OCT configuration and used a supercontinuum laser as the illumating source. The center wavelength was 564 nm and the bandwidth was 115 nm, which provided a 0.97 µm axial resolution measured in air. We characterized the sensitivity to be 86 dB with 226 µW incidence power on the pupil. We also integrated an SLO that shared the same optical path of the vis-OCT sample arm for alignment purposes. We demonstrated the retinal imaging from both ...

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    16. ZEISS Sets the Pace in OCT Innovation with First FDA 510(k) Clearance of OCT Angiography Technology

      ZEISS Sets the Pace in OCT Innovation with First FDA 510(k) Clearance of OCT Angiography Technology

      D ZEISS Medical Technology announces that its AngioPlex OCT Angiography is the first such technology to receive 510(k) clearance from the U.S. Food and Drug Administration (FDA). “OCT angiography ushers in a new era in the evaluation of the retina in diabetic retinopathy and macular degeneration” With a single additional OCT scan that takes just seconds on the CIRRUS HD-OCT system from ZEISS, ophthalmologists can now utilize optical coherence tomography (OCT) images to assess the blood vessels (vasculature) of the retina at a depth and clarity never available before. AngioPlex OCT Angiography delivers high-resolution, depth-resolved visualization of the ...

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    17. Optical Coherence Tomography Glaucoma Detection Based On Retinal Vessel Relief Height

      Optical Coherence Tomography Glaucoma Detection Based On Retinal Vessel Relief Height

      Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach, a retinal vessel relief height relative to a retinal plane may be calculated from OCT image data and the presence or absence of a glaucoma condition may be determined based on the retinal vessel relief height.

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    18. Optical systems for whole eye imaging and biometry

      Optical systems for whole eye imaging and biometry

      Scanning optical beam imaging systems for imaging extended structures of an eye and providing biometry of an eye are provided. The systems include a focal system for shifting the focus of the scanning system from the front to the back of the eye. The systems provide for converging rays that can scan through the pupil of the eye, enabling scanning of the anterior and posterior segments of the eye using a common objective and a fixed working distance.

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    19. Superluminescent diode and optical coherence tomography apparatus including the superluminescent diode

      Superluminescent diode and optical coherence tomography apparatus including the superluminescent diode

      A superluminescent diode which amplifies light through stimulated amplification and outputs emitted beams from one of edges at two ends includes a cladding layer of a first conductivity type formed on a semiconductor substrate, an active layer formed on the cladding layer of the first conductivity type, a cladding layer of a second conductivity type formed on the active layer, and a multilayer film formed at the other edge opposite to the one edge that emits the beams, reflectance of which has wavelength dependence, and a spectral shape of the emitted beams output from the one edge is controllable by ...

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    20. System and method for generating and utilizing a valid sweep vector to obviate spurious data and increase sweep rate in an akinetic path-based swept laser

      System and method for generating and utilizing a valid sweep vector to obviate spurious data and increase sweep rate in an akinetic path-based swept laser

      A system and method for triggering data acquisition in a semiconductor laser system including outputting electromagnetic energy from the semiconductor laser over a range of wavelengths according to a signaling path. The signaling path includes a plurality of discrete data inputs to the semiconductor laser for outputting electromagnetic energy over a range of wavelengths and the signaling path includes one or more perturbances in transitioning from one wavelength to another wavelength along the signaling path. A series of triggering signals are generated for input to a measurement system by the semiconductor laser. The electromagnetic energy output from the semiconductor laser ...

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    21. Bioresorbable vascular scaffold overlap evaluation with optical coherence tomography after implantation with or without enhanced stent visualization system (WOLFIE study): a two-centre prospective comparison

      Bioresorbable vascular scaffold overlap evaluation with optical coherence tomography after implantation with or without enhanced stent visualization system (WOLFIE study): a two-centre prospective comparison

      To assess if enhanced stent visualization (ESV)-guided implantation of overlapping bioresorbable vascular scaffold (BVS) is superior to angiography alone-guided implantation in the reduction of overlap length. WOLFIE is a two-centre prospective open study enrolling 30 patients treated with implantation of at least two overlapping BVS. In the first centre (London), BVS implantation was guided by conventional angiography, while in the second centre (Ferrara), an ESV system was systematically employed. The primary endpoint of the study was overlap length. Secondary endpoints were: stacked struts number, area, thickness, and amount of clusters. In the ESV-guided group, overlap length was significantly lower ...

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    22. Call for Papers: OCT Special Issue

      Call for Papers: OCT Special Issue

      I In 2016, IOVS will publish a special issue on a technology that exemplifies the clinically relevant scope of the journal: Optical Coherence Tomography (OCT). IOVS welcomes manuscripts from any discipline using OCT technology to answer fundamental or clinically relevant questions in ophthalmology or vision research. Submitted manuscripts should describe original, hypothesis-driven work. Multimedia submissions are encouraged. Topics may include (but not limited to): Advances in OCT technology Advances in OCT signal and image processing Multimodal imaging which involves OCT Novel contrast mechanisms and functional OCT Fundamental and preclinical applications of OCT Clinical applications of OCT in eye diseases Using ...

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    23. GaAs-Based Superluminescent Light-Emitting Diodes with 290-nm Emission Bandwidth by Using Hybrid Quantum Well/Quantum Dot Structures

      GaAs-Based Superluminescent Light-Emitting Diodes with 290-nm Emission Bandwidth by Using Hybrid Quantum Well/Quantum Dot Structures

      A high-performance superluminescent light-emitting diode (SLD) based upon a hybrid quantum well (QW)/quantum dot (QD) active element is reported and is assessed with regard to the resolution obtainable in an optical coherence tomography system. We report on the appearance of strong emission from higher order optical transition from the QW in a hybrid QW/QD structure. This additional emission broadening method contributes significantly to obtaining a 3-dB linewidth of 290 nm centered at 1200 nm, with 2.4 mW at room temperature.

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  2. Popular Articles

  3. Optical Coherence Tomography News

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