1. All Articles

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    1. Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Optical coherence tomography (OCT) can be utilized with significant speckle reduction techniques and highly-scattering contrast agents for noninvasive, contrast-enhanced imaging of living tissues at the cellular scale. The advantages of reduced speckle noise and improved targeted contrast can be harnessed to track objects as small as 2 μm in vivo, which enables applications for cell tracking and quantification in living subjects. Here we demonstrate the use of Large Gold Nanorods (LGNRs) as contrast agents for detecting individual micron-sized polystyrene beads and single myeloma cells in blood circulation using speckle modulating-OCT (SM-OCT). This report marks the first time that OCT has ...

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    2. Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Background To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with nonproliferative DR (up to ETDRS Level 53) were evaluated with OCTA (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Seven-field photographs of the fundus were taken for DR staging according to the ETDRS-grading scheme. The vessel density in the superficial and deep capillary plexus (SCP and DCP, respectively ...

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    3. Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them ...

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    4. Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease

      Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease

      Following on from a previous finding that there was a significant association between the increase in inflammatory monocytes after AMI and microcirculation impairment, and another that direct rennin inhibitors mediate the suppression of inflammatory monocytes after AMI to improve myocardial relief rate, the researchers are setting out to: discover the significance of peripheral blood monocytes in microcirculation impairment; clarify the influence of renin/aldosterone (the renin-angiotensin-aldosterone system is the most important system involved in the regulation of systemic blood pressure, renal blood flow, and monocytes recruitment); and establish a treatment. Initially, the team conducted clinical research involving 50 patients with ...

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      Mentions: Yuichi Ozaki
    5. Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Objectives Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. This study describes UVFP microanatomy and identifies possible vocal fold atrophy using OCT. Methods Three UVFP patients (ages 1, 11, and 17 years) underwent bilateral OCT imaging using a ...

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    6. Optical coherence tomography for diagnosis of BCC

      Optical coherence tomography for diagnosis of BCC

      Basal cell carcinoma (BCC) is the most common form of skin cancer in the world. Its incidence in Europe has increased at an alarming rate of 5.5% per year over the past four decades. In the U.K., the incidence of BCC has risen at a rate six times higher than in the rest of Europe. The diagnosis of BCC typically requires a biopsy of the skin and careful analysis under a microscope. Optical coherence tomography (OCT) is an imaging tool that uses light to visualize the layers underneath the skin surface in real‐time without the need to ...

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    7. MUcociliary Clearance IN Stroke

      MUcociliary Clearance IN Stroke

      Survival and functional outcome of stroke is strongly depending on the occurence of pneumonia (stroke-associated pneumonia, SAP). Early diagnose and treatment of SAP is paramount in the treatment of stroke patients. While dysphagia strongly contributes to its pathogenesis, recent years have also shown a strong risk-modulation by CNS injury induced immunosuppression, making stroke patients more susceptible to SAP. Additionally, murine models of stroke showed changes in mucociliary clearance as possible contributors to SAP. It remains unclear, whether structural integrity and mucociliary clearance of the respiratory epithel change in stroke patients, and whether these changes might contribute to the occurence of ...

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    8. Optical Coherence Tomography Investigations and Modeling of the Sintering of Ceramic Crowns

      Optical Coherence Tomography Investigations and Modeling of the Sintering of Ceramic Crowns

      Dental prostheses are sintered in ovens that sometimes suffer from a loss of calibration. This can lead to variations of the sintering temperature outside the range recommended by the manufacturer. Stress and even fractures in dental ceramics may occur, and this leads to the necessity to rebuild the dental construct. The aim of this work is to monitor the quality of sintering processes using an established biomedical imaging technique—optical coherence tomography (OCT). Conventional current procedures imply the fabrication of supplemental samples that add to the expenses and are only evaluated visually. To our knowledge, we were the first to ...

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    9. Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Optovue , the global leader in the development of optical coherence tomography (OCT) and OCT angiography (OCTA), will launch its new AngioWellness™ scan at Vision Expo East in New York , March 21-24, 2019 . The AngioWellness scan utilizes Optovue's advanced AngioVue ® OCTA technology to quickly assess and diagnose new pathologies in patients, including diabetic patients and those who may be at risk for glaucoma. Sample AngioWellness Report AngioWellness combines structural information on retinal and ganglion cell thickness with objective metrics on retinal vasculature into one easy-to-read report. The first of its kind patient-monitoring tool was designed to help eye care professionals ...

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      Mentions: Optovue
    10. Photonics21 digs in for next phase of continental R&D

      Photonics21 digs in for next phase of continental R&D

      Laser pen for ‘while you wait' cancer test The Photonics21 team says that another successful PPP-related development has been delivered by the Automatic Detection of VAscular Networks for Cancer Evaluation (ADVANCE) project team. They have produced a portable laser scanner that can diagnose a malignant melanoma in less than one minute, promising to become what its developers describe as "the world‘s first while-you-wait test for skin cancer." The imaging system, intended to eliminate discomfort and uncertainty for patients, is able to fit every stage of disease identification within the short time of a single doctor's appointment. Using a ...

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    11. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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    12. Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Importance At one end of the coronary artery disease (CAD) spectrum, there are patients with multiple recurrent acute coronary syndromes (rACS), and at the other end there are those with long-standing clinical stability. Predicting the natural history of these patients is challenging because unstable plaques often heal without resulting in ACS. Objective To assess in vivo the coronary atherosclerotic phenotype as well as the prevalence and characteristics of healed coronary plaques by optical coherence tomography (OCT) imaging in patients at the extremes of the CAD spectrum. Design, Setting, and Participants This is an observational, single-center cohort study with prospective clinical ...

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    13. Cross-polarization optical coherence tomography for brain tumor imaging

      Cross-polarization optical coherence tomography for brain tumor imaging

      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) – OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An ...

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    14. Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Background / Objectives Automatic algorithms for stent struts segmentation in optical coherence tomography (OCT) images of coronary arteries have been developed over the years, particularly with application on metallic stents. The aim of this study is three-fold: (1) to develop and to validate a segmentation algorithm for the detection of both lumen contours and polymeric bioresorbable scaffold struts from 8-bit OCT images, (2) to develop a method for automatic OCT pullback quality assessment, and (3) to demonstrate the applicability of the segmentation algorithm for the creation of patient-specific stented coronary artery for local hemodynamics analysis. Methods The proposed OCT segmentation algorithm ...

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    15. Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Purpose Despite the controversial effect of elevated heart rate on progression of cardiac allograft vasculopathy (CAV), heart-rate-slowing agents are frequently prescribed with the assumption that higher heart rate predicts worse outcomes in cardiovascular disease. Methods This prospective 2-center trial investigated progression of CAV in 116 heart transplant (HTx) patients. Both baseline (1 month after HTx) and follow-up (12 months after HTx) examinations by coronary optical coherence tomography (OCT) were analyzed using highly automated 3D graph-based segmentation software. Mean heart rate was assessed by 24-hour ambulatory ECG monitoring at baseline and at 12-month follow-ups after HTx. Results During the first post-transplant ...

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    16. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Optical coherence tomography angiography (OCTA) has been widely used for <i>en face</i> visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the “tail” artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (<i>g</i><sub>1</sub>-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating arterioles from venules in the 3-D image. <i>g</i><sub>1</sub>   (  τ  )   is calculated from repeated optical coherence tomography (OCT) acquisitions for each spatial ...

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    17. Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Background/Purpose Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality used to assess coronary arteries and as an adjunctive tool for optimization of percutaneous coronary interventions. Overall, the rate of complications and adverse events related to intravascular imaging is low. Limited data exist on the most commonly reported complications and modes of failure related to the use of OCT. Therefore, we analyzed the post-marketing surveillance data from the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to assess the reported complications and failure modes for OCT and reviewed techniques to optimize device use. Methods ...

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    18. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Objectives Surgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic algorithm to improve on the current method of clinical evaluation of surgical margin in oral cancer. Materials and methods We have used a modified handheld OCT device with automated algorithm ...

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    19. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation remain poorly understood. Methods A total of 65 SCAD patients (68 vessels) who underwent acute OCT imaging as part of routine clinical care were included. Images were classified by the ...

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    20. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method is validated on phantoms composed of layers of different materials. Articular cartilage samples from adult swine are segmented with the method. The characteristics in each segmented zone are also examined ...

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    21. Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.

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    22. Distance, diameter and area determining device

      Distance, diameter and area determining device

      An elongated member such as a catheter that uses ultrasound or optical coherence tomography "OCT") technology to approximate the dimensions of a structure into which the catheter has been placed. The catheter includes multiple ultrasound transducers arranged in an annular or circumferential configuration on, embedded into or within the body of the elongated member so that distance measurements can be obtained between the elongated member and the wall of the immediately facing structure (e.g., a fluid-filled lumen). Utilizing these measurements, the present invention approximates for the physician the shape and size of the structure into which the elongated member ...

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    23. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the ...

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