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Popular Articles
The Evolution of Spectral Domain OCT
Ophthalmic Optical Coherence Tomography Market: Past, Present, & Future
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Optical Coherence Tomography News
Postdoctoral Position in The Biomedical Optics Laboratory at the University of Houston
Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010
Free Use of OCT Imaging System for One Month Sponsored by Thorlabs and OCT News
Postdoctoral Research Associate in Optical Engineering : Vanderbilt University, Nashville, TN
Senior Software Engineer Opening at Diagnostic Photonics
OSA Launches New Journal Biomedical Express
St. Jude Medical Files Patent Infringement Lawsuit Against Volcano Corporation in the U.S.
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OCT Products in the News
(315 articles) Zeiss Stratus OCT
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Organizations in the News
(195 articles) Massachusetts Institute of Technology
(169 articles) Harvard University
(137 articles) Massachusetts General Hospital
(129 articles) Duke University
(111 articles) University of Southern California
(107 articles) Medical University of Vienna
(91 articles) University of Miami
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Measurement of signal intensity depth profiles in rat brains with cardiac arrest maintaining primary temperature by wide-field optical coherence tomography
Explore Article opticsinfobase.org (Aug 31 2010)
We have already reported that after an injection for euthanasia, the signal intensity of optical coherence tomography (OCT) images are 2.7 times increased before cardiac arrest (CA) using OCT and rat brains without temperature control to show the potential of OCT to monitor tissue viability in brains [Appl. Opt. 48, 4354 (2009)]. In this paper, we similarly measured maintaining the primary temperature of rat brains. It was confirmed that when maintaining the primary temperature, the time courses of the ratios of signal intensity (RSIs) were almost the same as those without temperature control. RSIs after CA varied from 1.6 to ...
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Comment on Article Mentions: Manabu Sato Yamagata University
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Elastographic contrast generation in optical coherence tomography from a localized shear stress
Explore Article IOPscience (Aug 31 2010)
A technique for generating contrast in two-dimensional shear strain elastograms from a localized stress is presented. The technique involves generating a non-uniform, localized stress via a magnetically actuated implant. Its effectiveness is demonstrated using finite-element simulations and a phantom study provides experimental verification of this. The method is applied to a superficial cancerous lesion model represented as a stiff inclusion in normal tissue. The lesion was best distinguished from its surroundings using total shear strain elastograms, rather than individual strain components. In experimental phantom studies, the lesion was imaged using optical coherence tomography (OCT) and could still be distinguished in ...
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Comment on Article Mentions: Michelson Diagnostics Jon Holmes Pete H. Tomlins
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Fundus oculi observation device, a fundus oculi image display device and a fundus oculi image display method
Explore Article uspto.gov (Aug 31 2010)
A fundus oculi observation device comprises: a first image forming part for optically obtaining data and then forming a fluorescence image of a fundus oculi of an eye administered with a fluorescent agent in advance based on the obtained data; a second image forming part for optically obtaining data and then forming a tomographic image of the fundus oculi based on the obtained data; a display; and a controller for causing said display to display said fluorescence image formed by said first image forming part side-by-side with said tomographic image formed by said second image forming part, as well as ...
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Comment on Article Mentions: Topcon Medical Systems
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Optical fiber and broadband light source
Explore Article uspto.gov (Aug 31 2010)
An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area ...
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Miniaturized imaging device including utility aperture and SSID
Explore Article uspto.gov (Aug 31 2010)
The present invention is drawn toward miniaturized imaging devices. In one embodiment, the device can include a utility guide having at least one aperture configured for supporting utilities, and an SSID carried by the utility guide. The SSID can include an imaging array on a top surface, and a conductive element on a side surface, wherein the imaging array is electrically coupled to the conductive element. Further, a lens can be optically coupled to the imaging array, and an umbilical, including a conductive line, can be carried by the at least one aperture. The conductive line can be electrically coupled ...
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Method and apparatus for measurement of optical properties in tissue
Explore Article uspto.gov (Aug 31 2010)
A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
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Comment on Article Mentions: Stephen A. Boppart Julian J. Armstrong David D. Sampson
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Catheter device with a position sensor system for treating a vessel blockage using image monitoring
Explore Article uspto.gov (Aug 31 2010)
The invention relates to a catheter device, with a position sensor system, for treatment of a partial or complete vessel blockage under image monitoring, with the catheter device featuring a treatment catheter of a vessel blockage, especially by removal or destruction of plaque and/or expansion of the vessel, which is embodied as an integrated unit, especially as a combination catheter, with an OCT catheter and an IVUS catheter for image monitoring and with the position sensor system.
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Comment on Article Mentions: Siemens
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Evaluation of optical coherence tomography findings in age-related macular degeneration: a reproducibility study of two independent reading centres
Explore Article BJO Online (Aug 30 2010)
Background/aims To determine the reproducibility among readers of two independent certified centres, the Vienna Reading Center (VRC) and the University of Wisconsin-Madison Reading Center (UW-FPRC) for optical coherence tomography (OCT) images in age-related macular degeneration (AMD). Methods Fast macular thickness scans and 6 mm cross hair scans were obtained from 100 eyes with all subtypes of AMD using Stratus OCT. Consensus readings were performed by two certified OCT readers of each reading center using their grading protocol. Common variables of both grading protocols, such as presence of cystoid spaces, subretinal fluid, vitreomacular traction and retinal pigment epithelial detachment, were compared ...
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Comment on Article Mentions: University of Wisconsin Medical University of Vienna Zeiss Stratus OCT
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Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia
Explore Article BJO Online (Aug 30 2010)
Aim To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. Methods Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 and MM7 scan). The sensitivity and specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Area under the receiver operator characteristic (AUROC) curves were generated to assess the ability of each parameter to detect glaucomatous changes. Results 73 normal controls and 77 glaucoma ...
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Comment on Article Mentions: University of Ulsan Optovue RTVue-100 Yonsei University
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Postdoctoral Position in The Biomedical Optics Laboratory at the University of Houston
Explore Article Optical Coherence Tomography News (Aug 29 2010)
The Biomedical Optics Laboratory (http://www.egr.uh.edu/bol/) in Department of Biomedical Engineering at the University of Houston, TX invites applications for a postdoctoral scholar position in the area of optical coherence tomography (OCT) imaging and biophotonics. The initial appointment will be full-time, for a 12 month period. Salary will be based on level of experience. Renewal of the appointment will be contingent upon the availability of adequate funding and performance. The position is available immediately and review of the applications is ongoing. Applicants must have strong experience and interest in OCT system development and software engineering (using LabView , C/C++, OpenMP, multithreading). ...
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Comment on Article Mentions: Kirill V. Larin University of Houston
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Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010
Explore Article Optical Coherence Tomography News (Aug 29 2010)
The Industrial Materials Institute (IMI) organizes a one-day symposium on Optical Coherence Tomography (OCT) on Tuesday September 28, 2010, at Université Laval (Quebec City). The goals of the symposium are to increase networking between research groups and to provide interested parties an overview of the current status of OCT research in Canada.
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Comment on Article Mentions: Novacam Technologies Kostadinka K. Bizheva Victor X. D. Yang
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Advances in Diagnostic Bronchoscopy
Explore Article ajrccm.atsjournals.org (Aug 28 2010)
Diagnostic bronchoscopy has undergone two major paradigm shifts in the last 40 years. First, the advent of flexible bronchoscopy gave chest physicians improved access to the tracheobronchial tree with a rapid learning curve and greater patient comfort compared with rigid bronchoscopy. The second paradigm shift has evolved over the last 5 years with the proliferation of new technologies that have significantly enhanced the diagnostic capabilities of flexible bronchoscopy compared with traditional methods. At the forefront of these new technologies is endobronchial ultrasound. In its various forms, endobronchial ultrasound has improved diagnostic yield for pulmonary masses, nodules, intrathoracic adenopathy, and disease ...
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A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
Explore Article Oxford Journals (Aug 27 2010)
Following an episode of optic neuritis, thinning of the retinal nerve fibre layer, which indicates axonal loss, is observed using optical coherence tomography. The longitudinal course of the retinal changes has not been well characterized. We performed a serial optical coherence tomography study in patients presenting with optic neuritis in order to define the temporal evolution of retinal nerve fibre layer changes and to estimate sample sizes for proof-of-concept trials of neuroprotection using retinal nerve fibre layer loss as the outcome measure. Twenty-three patients (7 male, 16 female, mean age 31 years) with acute clinically isolated unilateral optic neuritis were ...
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Comment on Article Mentions: University College London
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Advice for Students Interested in Optics and Photonics from Leaders in the Optics and Photonics Community
Explore Article YouTube (Aug 27 2010)
SPIE asked leaders in the optics and photonics community to give some advice to students interested in the field. Astronomers, professors, CEOs, a Nobel Prize winner, and others all give their answer to the question, "What advice would you give to a student or young professional interested in optics and/or photonics?" This is a small collection of their responses
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Comment on Article Mentions: Massachusetts Institute of Technology James G. Fujimoto Oregon Health & Science University
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Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation
Explore Article opticsinfobase.org (Aug 27 2010)
Stephanie J. Chiu, , Peter Nicholas, Cynthia A. Toth, Joseph A. Izatt, Sina FarsiuSegmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach for segmenting retinal layers in Spectral ... [Opt. Express 18, 19413-19428 (2010)]
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Comment on Article Mentions: Cynthia A. Toth Joseph A. Izatt Duke University
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Jim Fujimoto talks about biophotonics and optical coherence tomography
Explore Article YouTube (Aug 26 2010)
James. G. Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT). The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT). The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT. Fujimoto's area of research involves the development and application of femtosecond laser technology, studies of ultrafast phenomena, and laser medicine and surgery. He is chair of the annual Biomedical ...
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Comment on Article Mentions: Massachusetts Institute of Technology James G. Fujimoto
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Free Use of OCT Imaging System for One Month Sponsored by Thorlabs and OCT News
Explore Article Optical Coherence Tomography News (Aug 26 2010)
Thorlabs, in collaboration with OCT News, is pleased to offer FREE use of a 1300 nm Swept Source OCT Imaging System for one month to two qualified research groups. Thorlabs is dedicated to promoting photonics-based research around the world and has a long history of collaborating with and supporting academic and other non-profit institutions. Our mission is to help advance the photonics industry by providing optical products inspired by true customer needs. We also have a rapidly growing family of imaging-related products including a variety of OCT imaging systems. In particular, Thorlabs' best selling OCT system is the OCS1300SS Swept ... (Read Full Article)
Comment on Article Mentions: Thorlabs
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Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units
Explore Article opticsinfobase.org (Aug 26 2010)
The real-time display of full-range, 2048 axial pixel×1024 lateral pixel, Fourier-domain optical-coherence tomography (FD-OCT) images is demonstrated. The required speed was achieved by using dual graphic processing units (GPUs) with many stream processors to realize highly parallel processing. We used a zero-filling technique, including a forward Fourier transform, a zero padding to increase the axial data-array size to 8192, an inverse-Fourier transform back to the spectral domain, a linear interpolation from wavelength to wavenumber, a lateral Hilbert transform to obtain the complex spectrum, a Fourier transform to obtain the axial profiles, and a log scaling. The data-transfer time of the ...
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Comment on Article Mentions: Yuuki Watanabe Yamagata University
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Postdoctoral Research Associate in Optical Engineering : Vanderbilt University, Nashville, TN
Explore Article Optical Coherence Tomography News (Aug 25 2010)
Science jobs from Vanderbilt University Department of Biomedical Engineering: Description:Applications are invited for a Postdoctoral research Associate position in the Department of Biomedical Engineering at Vanderbilt University. The objective of our research is to engineer imaging techniques for the quantitative assessment of molecular and hemodynamic changes associated with oncogenesis and cancer progression. The Postdoctoral Research Associate will be involved in the development and application of optical coherence tomography (OCT) systems for pre-clinical studies and will work in collaboration with engineers and biologists. The applicant will have access to state-of-the-art resources in biomedical photonics. This position will also provide a unique ...
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Comment on Article Mentions: Melissa C. Skala
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Optical Coherence Tomography for Corneal Diseases
Explore Article LWW Online (Aug 25 2010)
Anterior segment optical coherence tomography (OCT) is currently used for investigating the distribution of the corneal thickness, shape of the stromal interface after lamellar corneal surgery, association between host and corneal graft in keratoplasty, dimension of the anterior chamber, and lesions of the corneal diseases. In addition, the advances of OCT technology has enabled three-dimensional imaging, tissue imaging, cell imaging, and topographic analysis. In this review, examples of tissue imaging with 840-nm spectral-domain OCT, cell imaging with full-field OCT, and corneal topographic analysis with 1,310-nm swept-source OCT were introduced.
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Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
Explore Article ScienceDirect (Aug 25 2010)
In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that increasing the force used for MN application resulted in a significant increase in ...
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Relationship Between Arterial and Fibrous Cap Remodeling: A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study
Explore Article Circulation (Aug 25 2010)
Background—Positive arterial remodeling and thin fibrous cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the fibrous cap thickness and the relationship between serial arterial remodeling and changes in fibrous cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in fibrous cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results—Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 ...
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Comment on Article Mentions: Stanford University Hiroyuki Okura Teruyoshi Kume
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Evaluation of stent placement and outcomes with optical coherence tomography
Explore Article futuremedicine.com (Aug 25 2010)
Optical coherence tomography (OCT) is an imaging modality based on fiberoptic technology. OCT imaging systems use optical imaging catheters that emit near-infrared light to produce high resolution, real-time images. The frequencies and bandwidths of infrared light are far higher than medical ultrasound signals, resulting in greatly increased image resolution, which is approximately ten-times higher than that of intravascular ultrasound. Compared with conventional imaging modalities, OCT is superior for the evaluation of vulnerable plaque features, which may be associated with a higher risk of peri-interventional myocardial infarction, such as plaque rupture, thrombus, thin-capped fibroatheroma and macrophages within the fibrous caps. OCT ...
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Comment on Article Mentions: Junya Shite Toshiro Shinke Kobe University Graduate School of Medicine
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Versatile corneal, anterior segment imaging technologies improve accuracy
Explore Article OSN Supersite (Aug 25 2010)
An eclectic array of anterior segment testing and measurement technologies enable cataract and refractive surgeons to accurately assess anatomic features to optimize clinical and visual outcomes. Anterior segment optical coherence tomography, very high-frequency ultrasound biomicroscopy and Scheimpflug photography help surgeons assess corneal thickness and topography, anterior chamber depth and axial length, and iris and ciliary body status. Used alone or in combination, these modalities also help surgeons manage complications.
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Comment on Article Mentions: Optovue Carl Zeiss Meditec David Huang
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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