1. Recent Articles From Around The Web

    1. Multimodality coronary imaging to predict periprocedural myocardial necrosis after an elective percutaneous coronary intervention

      Multimodality coronary imaging to predict periprocedural myocardial necrosis after an elective percutaneous coronary intervention

      Background Although multiple imaging modalities have been tested to predict periprocedural myocardial necrosis (PMN), the superior predictive efficacy of these imaging findings has not been established fully. We sought to evaluate which findings of the coronary imaging tools would best provide predictive efficacy of PMN among optical coherence tomography (OCT), intravascular ultrasound (IVUS), and coronary computed tomography (CCT) angiography. Patients and methods A total of 130 patients with stable angina pectoris who underwent OCT, IVUS, and CCT examinations for a single de-novo preprocedural lesion were investigated. PMN was defined on the basis of two different thresholds of cardiac troponin I ...

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    2. SURGICAL REMOVAL OF EPIRETINAL MEMBRANE WITH AND WITHOUT REMOVAL OF INTERNAL LIMITING MEMBRANE: Comparative Study of Visual Acuity, Features of Optical Coherence Tomography, and Recurrence Rate

      SURGICAL REMOVAL OF EPIRETINAL MEMBRANE WITH AND WITHOUT REMOVAL OF INTERNAL LIMITING MEMBRANE: Comparative Study of Visual Acuity, Features of Optical Coherence Tomography, and Recurrence Rate

      Purpose: To study and compare visual acuity, foveal thickness, outer limiting layer, ellipsoid zone, and recurrence rate in patients undergoing removal of the epiretinal membrane with and without the removal of the internal limiting membrane (ILM). Methods: Sixty-three patients who had the epiretinal membrane removed by a single surgeon were randomly assigned into 2 groups: Group 1 without additional removal of the ILM and Group 2 with removal of the ILM. Patients were followed up and evaluated at the first month, third month, and sixth month, postoperatively. Results: Patients from both groups had a gradual improvement in their vision over ...

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    3. Automatic Side Branch Ostium Detection and Main Vascular Segmentation in Intravascular Optical Coherence Tomography Images

      Automatic Side Branch Ostium Detection and Main Vascular Segmentation in Intravascular Optical Coherence Tomography Images

      Intravascular optical coherence tomography (IVOCT) is the state-of-the-art imaging modality in percutaneous coronary intervention (PCI) planning and evaluation, in which side branch ostium and main vascular measurements play critical roles. However, manual measurement is time consuming and labor intensive. In this paper, we propose a fully automatic method for side branch ostium detection and main vascular segmentation to make up manual deficiency. In our method, side branch ostium points are firstly detected and subsequently used to divide the lumen contour into side branch and main vascular regions. Based on the division, main vascular contour is then smoothly fitted for segmentation ...

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    4. Optical Coherence Tomography in Patients With Chronic Migraine: Literature Review and Update

      Optical Coherence Tomography in Patients With Chronic Migraine: Literature Review and Update

      Migraine is a chronic disease characterized by unilateral, pulsating, and often moderate-to-severe recurrent episodes of headache with nausea and vomiting. It affects approximately 15% of the general population, yet the underlying pathophysiological mechanisms are not fully understood. Optical coherence tomography (OCT) is a safe and reproducible diagnostic technique that utilizes infrared wavelengths and has a sensitivity of 8-10 micrometers. It can be used to measure thinning of the retinal nerve fiber layer (RNFL) in some neurological disorders. Although ophthalmologists are often the first specialists to examine patients with migraine, few studies have addressed the involvement of the optic nerve and ...

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    5. IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To examine the involvement of the retinal pigment epithelium (RPE) in the presence of vitelliform macular lesions (VML) in Best vitelliform macular dystrophy (BVMD), autosomal recessive bestrophinopathy, and adult-onset vitelliform macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT). Methods: A total of 35 eyes of 18 patients were imaged using a PS-OCT system and blue light fundus autofluorescence imaging. Pathogenic mutations in the BEST1 gene, 3 of which were new, were detected in all patients with BVMD and autosomal recessive bestrophinopathy. Results: Polarization-sensitive optical coherence tomography showed a characteristic pattern in all three diseases with nondepolarizing material in the ...

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    6. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany ...

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    7. In Vivo Non-Destructive Monitoring of Capsicum Annuum Seed Growth with Diverse NaCl Concentrations Using Optical Detection Technique

      In Vivo Non-Destructive Monitoring of Capsicum Annuum Seed Growth with Diverse NaCl Concentrations Using Optical Detection Technique

      We demonstrate that optical coherence tomography (OCT) is a plausible optical tool for in vivo detection of plant seeds and its morphological changes during growth. To investigate the direct impact of salt stress on seed germination, the experiment was conducted using Capsicum annuum seeds that were treated with different molar concentrations of NaCl. To determine the optimal concentration for the seed growth, the seeds were monitored for nine consecutive days. In vivo two-dimensional OCT images of the treated seeds were obtained and compared with the images of seeds that were grown using sterile distilled water. The obtained results confirm the ...

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    8. Widely tunable short cavity laser

      Widely tunable short cavity laser

      A tunable source includes a short-cavity laser optimized for performance and reliability in SSOCT imaging systems, spectroscopic detection systems, and other types of detection and sensing systems. The short cavity laser has a large free spectral range cavity, fast tuning response and single transverse, longitudinal and polarization mode operation, and includes embodiments for fast and wide tuning, and optimized spectral shaping. Disclosed are both electrical and optical pumping in a MEMS-VCSEL geometry with mirror and gain regions optimized for wide tuning, high output power, and a variety of preferred wavelength ranges; and a semiconductor optical amplifier, combined with the short-cavity ...

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    9. Spectral-Domain Optical Coherence Tomography Angiography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

      Spectral-Domain Optical Coherence Tomography Angiography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

      Purpose: To compare the diagnostic ability of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV). Methods: Retrospective review of 47 eyes with PCV imaged with ICGA and OCTA. For each eye, it was determined which imaging modality better delineated the PCV complex. The presence of a branching vascular network (BVN) and polyp(s) were noted. Results: PCV was better visualized with ICGA in 21 eyes (44.7%) and with OCTA in 9 eyes (19.2%). The results were comparable in 17 eyes (36.2%). Of the 44 eyes with BVN on ICGA, 41 ...

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    10. Optical Coherence Tomography in Macular Diseases and Glaucoma - Basic Knowledge

      Optical Coherence Tomography in Macular Diseases and Glaucoma - Basic Knowledge

      OCT has shed a discerning light on conditions related to vitreo-retinal interface such as vitreo-macular traction and macular holes. Another significant use of OCT is in its ability to enhance long follow ups of various retinal conditions in a quantitative and non -invasive manner. OCT images contain much information on the retina structure and have an important role in the evaluation of the disease progression and the response to therapy.

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    11. The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

      The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

      We read with interest the article by Tan et al. 1 entitled “The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy.” We congratulate the authors for the excellent description of the origins and long-term evolution of an optical coherence tomography (OCT) feature named “plateau” in nascent geographic atrophy and for proposing its histologic correlate. Querques et al. 2 first reported this tomographic signature in geographic atrophy with the name of “wedge-shaped subretinal hyporeflectivity.” However, the authors renamed this finding for the following reasons. First, they raise concerns for having two “hyporeflective wedge'' descriptors in the ...

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    12. Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography

      Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography

      Purpose: To map and view the effects of age, gender, and axial length on seven individual retinal layers around the optic nerve head (ONH). Methods: We scanned 242 healthy patients using the Spectralis spectral domain optical coherence tomography in an outpatient setting. The layers were observed on the Early Treatment Diabetic Retinopathy Study sectors using the standard Spectralis Family Acquisition Module 6.0.11.0. The center was the ONH, the inner circle (IC) was 1–3 mm away, and the outer circle (OC) was 3–6 mm away. The seven layers were retinal nerve fiber layer (RNFL), ganglion cell ...

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    13. Study by ARVO authors finds vision research pays for itself

      Study by ARVO authors finds vision research pays for itself

      Manage ARVO e-News Search Back Issues In This Issue Just published: Study by ARVO authors finds vision research pays for itself Events and education Registration is open for the Ocular Oncogenesis and Oncology Conference Take the Online Education courses: Big data and Demystifying statistics Members in the news In memoriam In remembrance U.S. Advocacy Updated NIH clinical trials definition goes into effect ARVOJobs Openings in several U.S. cities Grants and awards Funding opportunities Awards Just published: Study by ARVO authors finds vision research pays for itself Researchers have shown that optical coherence tomography (OCT) has saved Medicare $9 ...

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  5. Picture Gallery

    Post Doc Position for Adaptive Optics Optical Coherence Tomography at the Medical University Vienna New Study Finds Federally-Funded Technology Saved Medicare $9 Billion PhD Position in Advanced Ophthalmic Imaging at Indiana University Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease Research Associate / Research Fellow Microscope-in-a-Needle at the University of Western Australia IVUS-Guided Versus OCT-Guided Coronary Stent Implantation: A Critical Appraisal A Radio Podcast from New Retina Radio on OCT and Anti-VEGF, A Biography Multimodality coronary imaging to predict periprocedural myocardial necrosis after an elective percutaneous coronary intervention SURGICAL REMOVAL OF EPIRETINAL MEMBRANE WITH AND WITHOUT REMOVAL OF INTERNAL LIMITING MEMBRANE: Comparative Study of Visual Acuity, Features of Optical Coherence Tomography, and Recurrence Rate Automatic Side Branch Ostium Detection and Main Vascular Segmentation in Intravascular Optical Coherence Tomography Images Optical Coherence Tomography in Patients With Chronic Migraine: Literature Review and Update
  6. Recent Quotes

    1. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen
    2. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    3. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    4. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei
    5. Combining en-face OCT with movement detection within blood vessels, we get OCT-A, and with it a new imaging era.
      By Eric H. Souied
    6. Obtaining the Category III CPT code for OCT of the skin is an important step towards our goal of obtaining reimbursement and coverage, and we welcome the new codes that can be used by clinicians to record their clinical use of VivoSight OCT in their practice.
      By Jon Holmes
    7. We showed that you can take effectively any OCT system out there and, with minimal changes, boost its resolution to the point where it can detect anatomical features smaller than the size of a typical cell.
      By Adam de la Zerda
    8. This honor highlights the commitment Avinger has to bring the most advanced technology to market for physicians dedicated to treating PAD and their patients who are affected by this disease...Pantheris radically changes the treatment of vascular disease and the Edison Award represents a win for our entire Lumivascular portfolio.
      By John B. Simpson
    9. While we have been actively advancing our lesion assessment technology for the last two years, we are very pleased to see that the significant Series B investment will give MedLumics the means to complete our best-in-class product, conduct a series of international clinical trials to prove its safety and efficacy, and market it to specialist centers. As the company advances and grows into new areas, we will now expand and develop the team internationally.
      By Eduardo Margallo Balbás
    10. It's the most rapidly adopted ophthalmic technology in history.
      By Joel S. Schuman