1. Recent Articles From Around The Web

    1. Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Patients undergo collection of tears, saliva, buccal mucosa, and fecal samples before stem cell transplant, at 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients also undergo collection of blood samples before stem cell transplant, at 1-2, 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients may undergo skin and mouth biopsy over 15-30 minutes before stem cell transplant, at 2-3 and 12 months after stem cell transplant, and at cGVHD onset. Patients undergo digital pictures of the eyes, mouth and skin, and optical ...

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    2. Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      The advent of optical coherence tomography angiography (OCTA), a relatively new tool to image the retinal and choroidal microvasculature with depth-resolved capability, has been met with great excitement by some ophthalmologists. This noninvasive technology is a potentially valuable instrument to differentiate flow impairment in the superficial vs deep retinal capillary plexus, and it can quantify nonperfusion in eyes with retinal vascular disease. Moreover, OCTA has advanced understanding of the microvascular morphology of choroidal neovascularization and has demonstrated its various growth patterns.  It also has highlighted the potential importance of inner choroidal flow impairments associated with the development and progression of ...

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    3. Artificial Intelligence and Healthcare: Products and Procedures

      Artificial Intelligence and Healthcare: Products and Procedures

      This paper focuses on statutory regulation of learning machines that qualify as medical devices. After a brief case study, the article takes a procedural perspective and presents the main features of the European regulatory framework that applies to medical devices in order to identify the regulatory peculiarities in the use of machine learning. In this context, the Chapter will analyse the immanent risks of machine learning applications as medical devices as well as the role of machine learning in their regulation. The overall finding is that due to its lack of expertise and material equipment the state activates private companies ...

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    4. Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      The overall goal of this book is to provide the reader with an understanding of the new minimally invasive techniques that are available for the purpose of diagnostic imaging in dentistry and to explain their impact on clinical practice. The book concentrates very much on those techniques that are clinically applicable and useful to dentists NOW, although it also provides a fascinating view to the future. The chapters are divided according to the major clinical topics in dentistry. Each chapter provides considerable visual content, including flow charts, schematics, and photographs. The principles of the technologies presented are discussed in an ...

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    5. Machine learning, imaging technique may boost colon cancer diagnosis

      Machine learning, imaging technique may boost colon cancer diagnosis

      Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...

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    6. Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Background/Objectives Choroidal thinning has been suggested in Leber’s hereditary optic neuropathy (LHON). No study has been conducted of the choroid in relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought to measure choroidal thickness in chronic LHON and to correlate thickness changes with the RGC-IPL. Subjects/Methods Chronic LHON, 11778 mitochondrial DNA (mtDNA) mutation, patients (26 eyes; mean age: 35.1 ± 16.1 years) were prospectively recruited at Doheny Eye Center, University of California Los Angeles from March 2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 ± 11.1 years) were enroled ...

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    7. Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Combined central retinal artery and vein occlusion is an uncommon vascular pathology that can cause severe and permanent visual impairment. Optical coherence tomography angiography (OCTA) is a newly available, noninvasive imaging technique that can potentially improve understanding of the structural and vascular implications and prognosis of this infrequent pathology. The present report describes the principal clinical findings in a case of combined central retinal artery and vein occlusion, as detected by the different imaging modalities available in a tertiary referral hospital. OCTA wide-field montage images identified an extensive area of nonperfusion on the macula with involvement of the entire retina ...

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    8. Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Optical coherence tomography angiography (OCT-A) represents the most recent modality in retinal imaging for non-invasive and depth-selective visualization of blood flow in retinal vessels. With regard to quantitative OCTA measurements for early detection of subclinical alterations, it is of great interest, which intra- and extra-ocular factors affect the results of OCTA measurements. Here, we performed OCTA imaging of the central retina in 65 eyes of 65 young healthy female and male participants and evaluated individual physical fitness levels by standard lactate diagnostic using an incremental maximal performance running test. The main finding was that OCTA measurements of the foveal avascular ...

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    9. Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      At clinical conferences and in publications, use of the term real world is widespread. It describes physicians’ accumulated experience in treating patients. It is contrasted with academic trials. Randomized clinical trials differ from practice in that they have fixed prespecified inclusion and exclusion criteria, adherence to a prespecified protocol, and ideally good patient retention. Randomized clinical trials have an advantage against observational studies when comparing treatments because they largely control for confounders, bias, and chance. Patient and treatment selection bias, losses to follow-up, outcome measurement, and imaging variability as well as many other confounding and bias factors can have large ...

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    10. Prevalence of dengue-related fundus and macular optical coherence tomography findings among inpatients in a regional referral hospital

      Prevalence of dengue-related fundus and macular optical coherence tomography findings among inpatients in a regional referral hospital

      Purpose: To investigate the prevalence of fundus and macular optical coherence tomography (OCT) findings, and the spectrum of dengue-related fundus presentation in a Malaysian tertiary hospital. The associations between platelet count and haematocrit level with fundus and macular OCT findings were also investigated. Design: Cross-sectional study. Methods: The study was conducted at Hospital Raja Permaisuri Bainun, Ipoh, from June to August 2015. Patients who consented to participate underwent a comprehensive ocular examination. Examination included a best-corrected distance (6 m) and near visual acuities, standard black-on-white Amsler chart testing, pupillary light reflex, fundus examination, followed by dilated fundus photographs and OCT ...

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    11. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a systematic literature review to assess the percentage of articles that report correcting the scale of their OCTA images for individual differences in retinal magnification. Evidence Review A PubMed (MEDLINE) search ...

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    12. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical ...

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    13. Monte Carlo Methods for Simulation of Optical Coherence Tomography of Turbid Media

      Monte Carlo Methods for Simulation of Optical Coherence Tomography of Turbid Media

      We describe two importance sampling techniques for a standard Monte Carlo (MC) method that could enable fast simulation of signals from optical coherence tomography (OCT) imaging systems. These OCT signals are generated due to diffusive reflections from either multilayered or arbitrary shaped, turbid media, for example, tissue. Such signals typically consist of ballistic and quasi-ballistic components, of scattered photons inside the medium, in addition to photons that undergo multiple scattering. We show that MC simulation of these OCT signals using importance sampling reduces its computation time on a serial processor by up to three orders of magnitude compared to its ...

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  2. Organizations in the News

    1. (2 articles) Johns Hopkins University
    2. (2 articles) Nanyang Technological University
    3. (1 articles) UCLA
    4. (1 articles) University of Houston
    5. (1 articles) Medical University of Vienna
    6. (1 articles) Korea University
    7. (1 articles) Singapore Eye Research Institute
    8. (1 articles) Cornell University
    9. (1 articles) Washington University in St. Louis
    10. (1 articles) SUNY at Stony Brook
  3. People in the News

    1. (2 articles) Linbo Liu
    2. (1 articles) Srinivas R. Sadda
    3. (1 articles) Jodhbir S. Mehta
    4. (1 articles) David L. Wilson
    5. (1 articles) Santiago Jiménez-Valero
    6. (1 articles) Gary S. Mintz
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    9. (1 articles) Marc D. Feldman
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    11. (1 articles) Fred K. Chen
    12. (1 articles) Hiram G. Bezerra
    13. (1 articles) Quing Zhu
    14. (1 articles) Kirill V. Larin
    15. (1 articles) Ursula Schmidt-Erfurth
  4. OCT Companies in the News

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  5. Picture Gallery

    GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital Australia’s Cylite promises the next generation OCT PhD Opening at Indiana University Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing Intravascular Polarimetry in Patients With Coronary Artery Disease
  6. Recent Quotes

    1. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    2. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    3. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    4. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    5. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    6. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    7. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    8. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    9. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    10. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood