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  3. Organizations in the News

    (1 articles) Ryerson University

    (1 articles) National Research Council Canada

    (1 articles) Yonsei University

    (1 articles) University of Ulsan

    (1 articles) Yamagata University

    (1 articles) University of Western Australia

    (1 articles) University of Illinois at Urbana-Champaign

    (1 articles) Harvard University

    (1 articles) University of Houston

    (1 articles) Oregon Health & Science University

  4. People in the News

    (1 articles) Alex Grimwood

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    (1 articles) Sebastien Vergnole

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  5. OCT Companies in the News

    (1 articles) Carl Zeiss Meditec

    (1 articles) Siemens

    (1 articles) Novacam Technologies

    (1 articles) Topcon Medical Systems

    (1 articles) Michelson Diagnostics

  6. OCT Products in the News

    (1 articles) Optovue RTVue-100

    (1 articles) Zeiss Stratus OCT

  7. Picture Gallery

  8. Popular Articles

  9. Recent Quotes

    1. “ Confocal microscopy of the cornea has been around for a long time but it still doesn’t have a lot of specificity in looking at microorganisms...Some sort of in vivo staining or fluorescence that allows us to really distinguish infections or microorganisms with confocal imaging would be great ”
      By David Huang
    2. “ There are a few circumstances where mapping the posterior surface is also useful, for example, in post-LASIK cataract surgery intraocular lens calculations, where measuring the anterior surface alone is not sufficient to really accurately measure the net corneal power. ”
      By David Huang
    3. “ OCT is also becoming enormously important in diagnosing and understanding cardiac disease as well as understanding diseases of the windpipe...We're still funding work to study airway injury in windpipes due to smoke inhalation or chemical inhalation. And again, we're using OCT to do that. ”
      By Howard Schlossberg
    4. “ The goal is to get this in the hands of physicians who can learn about OCT and then practice, using our simulation techniques. ”
      By Karl Wilkens
    5. “ Combining OCT with a balloon deployment system provides an improved platform for angioplasty balloon development and can also be used in the development of next-generation minimally invasive devices for percutaneous -- through the skin -- coronary interventions...It's now possible to monitor balloon inflation within an artery phantom (model) or an excised artery to assess the efficiency of innovative balloon angioplasty or stent deployment procedures. ”
      By Guy Lamouche
    6. “ OCT can be used for a variety of organs, but ovarian cancer caught my attention because it is such a devastating disease...It is a challenge because the ovaries are inside the body and there is no screening technique that works well and most women don’t have any symptoms until it is very advanced...So if we want to look at them with OCT you would have to get right up against the ovary. That won’t work in the general population, but there is a group of women who have high risk of ovarian cancer doctors often recommend removing them. Now that might not be a difficult decision to make in your 60s but that is a terrible decision to have to make in your 20s. Our idea is that if we could tell with certainty the ovaries were normal then that woman could keep her ovaries and just be screened every couple of years. ”
      By Jennifer K. Barton
    7. “ We continued to drive growth in both our intravascular ultrasound (IVUS) and Functional Measurement (FM) businesses, which grew 25 and 51 percent year-over-year, respectively. In the quarter, overall IVUS disposable revenues increased 29 percent versus the prior year, and our FM business increased 50 percent in both the U.S. and Europe...During the quarter, we introduced significant enhancements to our IVUS and FM disposables and our multi-modality console operating software, and commenced the European launch of our VIBE RX Vascular Imaging Catheter. In addition, we completed a number of cases utilizing the latest version of our Optical Coherence Tomography (OCT) catheter and system. ”
      By Scott Huennekens
    8. “ We continued to drive growth in both our intravascular ultrasound (IVUS) and Functional Measurement (FM) businesses, which grew 25 and 51 percent year-over-year, respectively. In the quarter, overall IVUS disposable revenues increased 29 percent versus the prior year, and our FM business increased 50 percent in both the U.S. and Europe...During the quarter, we introduced significant enhancements to our IVUS and FM disposables and our multi-modality console operating software, and commenced the European launch of our VIBE RX Vascular Imaging Catheter. In addition, we completed a number of cases utilizing the latest version of our Optical Coherence Tomography (OCT) catheter and system. ”
      By Scott Huennekens
    9. “ The difference in quality between an OCT image and an IVUS image has been described as analogous to the difference between an analog black-and-white television with a rabbit ear antenna and a digital color television with an high-definition image...We think OCT has the potential to obsolete IVUS imaging in the practices of many physicians. ”
      By Daniel J. Starks
    10. “ St. Jude Medical has made significant investments in the interventional cardiology space, including the coronary assessment and more recently the coronary imaging markets....From clinical research to important product advancements, Radi Medical Systems and now St. Jude Medical have contributed considerably to the success of this marketplace. As a company that values the innovations we bring to the marketplace, we intend to protect our intellectual property. ”
      By Frank Callaghan

  1. Advice to Students from Leaders in the Optics and Photonics Community

  2. Featured Articles

    1. Measurement of signal intensity depth profiles in rat brains with cardiac arrest maintaining primary temperature by wide-field optical coherence tomography

      Explore Article opticsinfobase.org (Aug 31 2010) Neurology

      Measurement of signal intensity depth profiles in rat brains with cardiac arrest maintaining primary temperature by wide-field optical coherence tomography We have already reported that after an injection for euthanasia, the signal intensity of optical coherence tomography (OCT) images are 2.7 times increased before cardiac arrest (CA) using OCT and rat brains without temperature control to show the potential of OCT to monitor tissue viability in brains [Appl. Opt. 48, 4354 (2009)]. In this paper, we similarly measured maintaining the primary temperature of rat brains. It was confirmed that when maintaining the primary temperature, the time courses of the ratios of signal intensity (RSIs) were almost the same as those without temperature control. RSIs after CA varied from 1.6 to ... (Read Full Article)

      Comment on Article Mentions:   Manabu Sato   Yamagata University

    2. Elastographic contrast generation in optical coherence tomography from a localized shear stress

      Explore Article IOPscience (Aug 31 2010)

      Elastographic contrast generation in optical coherence tomography from a localized shear stress A technique for generating contrast in two-dimensional shear strain elastograms from a localized stress is presented. The technique involves generating a non-uniform, localized stress via a magnetically actuated implant. Its effectiveness is demonstrated using finite-element simulations and a phantom study provides experimental verification of this. The method is applied to a superficial cancerous lesion model represented as a stiff inclusion in normal tissue. The lesion was best distinguished from its surroundings using total shear strain elastograms, rather than individual strain components. In experimental phantom studies, the lesion was imaged using optical coherence tomography (OCT) and could still be distinguished in ... (Read Full Article)

      Comment on Article Mentions:   Michelson Diagnostics   Jon Holmes   Pete H. Tomlins

    3. Method and apparatus for measurement of optical properties in tissue

      Explore Article uspto.gov (Aug 31 2010) Patents , Probes

      Method and apparatus for measurement of optical properties in tissue A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source. (Read Full Article)

      Comment on Article Mentions:   Stephen A. Boppart   Julian J. Armstrong   David D. Sampson

    4. Postdoctoral Position in The Biomedical Optics Laboratory at the University of Houston

      Explore Article Optical Coherence Tomography News (Aug 29 2010) Jobs & Studentships

      Postdoctoral Position in The Biomedical Optics Laboratory at the University of Houston The Biomedical Optics Laboratory (http://www.egr.uh.edu/bol/) in Department of Biomedical Engineering at the University of Houston, TX invites applications for a postdoctoral scholar position in the area of optical coherence tomography (OCT) imaging and biophotonics. The initial appointment will be full-time, for a 12 month period. Salary will be based on level of experience. Renewal of the appointment will be contingent upon the availability of adequate funding and performance. The position is available immediately and review of the applications is ongoing. Applicants must have strong experience and interest in OCT system development and software engineering (using LabView , C/C++, OpenMP, multithreading). ... (Read Full Article)

      Comment on Article Mentions:   Kirill V. Larin   University of Houston

    5. Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010

      Explore Article Optical Coherence Tomography News (Aug 29 2010)

      Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010 The Industrial Materials Institute (IMI) organizes a one-day symposium on Optical Coherence Tomography (OCT) on Tuesday September 28, 2010, at Université Laval (Quebec City). The goals of the symposium are to increase networking between research groups and to provide interested parties an overview of the current status of OCT research in Canada. (Read Full Article)

      Comment on Article Mentions:   Novacam Technologies   Kostadinka K. Bizheva   Victor X. D. Yang

    6. Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation

      Explore Article opticsinfobase.org (Aug 27 2010) Ophthalmology

      Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation Stephanie J. Chiu, , Peter Nicholas, Cynthia A. Toth, Joseph A. Izatt, Sina FarsiuSegmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach for segmenting retinal layers in Spectral ... [Opt. Express 18, 19413-19428 (2010)] (Read Full Article)

      Comment on Article Mentions:   Cynthia A. Toth   Joseph A. Izatt   Duke University

    7. Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units

      Explore Article opticsinfobase.org (Aug 26 2010)

      Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units The real-time display of full-range, 2048 axial pixel×1024 lateral pixel, Fourier-domain optical-coherence tomography (FD-OCT) images is demonstrated. The required speed was achieved by using dual graphic processing units (GPUs) with many stream processors to realize highly parallel processing. We used a zero-filling technique, including a forward Fourier transform, a zero padding to increase the axial data-array size to 8192, an inverse-Fourier transform back to the spectral domain, a linear interpolation from wavelength to wavenumber, a lateral Hilbert transform to obtain the complex spectrum, a Fourier transform to obtain the axial profiles, and a log scaling. The data-transfer time of the ... (Read Full Article)

      Comment on Article Mentions:   Yuuki Watanabe   Yamagata University

    8. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

      Explore Article ScienceDirect (Aug 25 2010) Dermatology

      Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that increasing the force used for MN application resulted in a significant increase in ... (Read Full Article)

      Comment on Article

    9. Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry

      Explore Article opticsinfobase.org (Aug 25 2010) Oncology

      Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated ... (Read Full Article)

      Comment on Article Mentions:   Francisco E. Robles   Yizheng Zhu   Duke University

    10. Senior Software Engineer Opening at Diagnostic Photonics

      Explore Article Optical Coherence Tomography News (Aug 24 2010) Jobs & Studentships

      Senior Software Engineer Opening at Diagnostic Photonics Senior Software Engineer Leadership. Responsibility. Impact. We are seeking a bright, energetic, and motivated senior software engineer to lead the development of the system software and user interface for a revolutionary medical imaging system. Our product could one day be used in imaging applications for millions of Americans each year, and we endeavor to improve the quality of human life. The senior software engineer will work with other talented engineers and university researchers on the company’s world-class imaging technology. We are offering a compensation package that includes a competitive base salary and an opportunity for stock options. Benefits include 401(k), ... (Read Full Article)

      Comment on Article Mentions:   Diagnostic Photonics

    11. Changes and Current State of Diagnosis of Lung Cancer After Development of the Flexible Bronchofiberscope

      Explore Article Oxford Journals (Aug 24 2010) Oncology , Pulmonology

      Changes and Current State of Diagnosis of Lung Cancer After Development of the Flexible Bronchofiberscope The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now enables diagnosis of extramural bronchial lesions. Bronchoscopy is also used for the treatment of early hilar lung cancer, and in patients with airway stenosis due to advanced cancer, laser therapy, brachytherapy, and stenting can be performed. The bronchofiberscope is also very useful for tissue sampling from the lung periphery. ... (Read Full Article)

      Comment on Article

    12. 5th International Graduate Summer School - Biophotonics '11 - May 14, 2011 in Ven, Sweden

      Explore Article Biomedical Optics and New Laser Systems (Aug 24 2010)

      5th International Graduate Summer School - Biophotonics '11 - May 14, 2011 in Ven, Sweden Over the past decade, optical methods and instruments based on light interacting with tissue have emerged as powerful techniques for bio-medical diagnostics, monitoring wide spectra of tissue function and pathology together with therapy. The purpose of the 5th International Graduate summer school Biophotonics '11 is to provide education for students at the highest international level within these areas. Moreover, by inviting renowned lecturers from all over the world, the educational program is held in an international atmosphere enhancing exchange of scientific ideas and technological advances within the fields of biomedical optics and closely related areas. The 5th International Graduate summer ... (Read Full Article)

      Comment on Article

    13. PhD scholarship in non-contact assessment of food quality using optical imaging methods at Technical University of Denmark

      Explore Article Optical Coherence Tomography News (Aug 24 2010) Jobs & Studentships

      PhD scholarship in non-contact assessment of food quality using optical imaging methods at Technical University of Denmark DTU Fotonik seeks a qualified candidate for a vacant PhD position. Candidates are invited to apply following the online procedure below.Project descriptionThe aim of the research project is to relate relevant food quality characteristics to optical properties of the food material. In particular, utilizing multiple scattering effects to quantify parameters such as scatterer size, orientation, and density distributions. In this project, different methodologies will be investigated. One method is based on extracting optical properties from diffuse reflectance profiles relating the optical properties to the physical properties of the sample. Another method is based on optical coherence microscopy from which optical ... (Read Full Article)

      Comment on Article Mentions:   Peter E. Andersen   Technical University of Denmark

    14. Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial

      Explore Article Heart (Aug 24 2010) Cardiology

      Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial Background A potentially adverse vascular response to overlapping drug eluting stents (DES) has been suggested in current research. Objective To evaluate the impact of baseline disease severity at the site of stent overlap. Methods and results This is a substudy of ODESSA, a prospective, randomised controlled trial designed to evaluate healing of overlapping stents. 71/77 patients with a total of 86 overlapping stents were studied: 25 sirolimus, 24 paclitaxel, 26 zotarolimus-eluting stents; and 11 bare metal stents (BMS). Patients were categorised into high-grade stenosis (HGS, ≥70% diameter stenosis) and low-grade stenosis (LGS, <70%) at the site of stent overlap. Angiography ... (Read Full Article)

      Comment on Article Mentions:   Case Western Reserve University   National Institutes of Health   LightLab Imaging

    15. >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging

      Explore Article opticsinfobase.org (Aug 23 2010) Tunable Sources

      >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging We demonstrate a high-speed wavelength-swept laser with a tuning range of 104nm (1228–1332nm) and a repetition rate of 403kHz. The design of the laser utilizes a high-finesse polygon-based wavelength-scanning filter and a short-length unidirectional ring resonator. Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98dB with single-side ranging depth of 1.7mm over 4dB sensitivity roll-off. (Read Full Article)

      Comment on Article Mentions:   Wang Yuhl Oh   Benjamin J. Vakoc   Milen Shishkov

    16. Piezo motors, actuators streamline medical device performance

      Explore Article Control Engineering (Aug 23 2010)

      Piezo motors, actuators streamline medical device performance For the execution of precise movements with medical equipment, the latest piezoceramic motors and actuators are more compact, require lower voltage, deliver higher torque, have shorter response time, generate less heat, and are nonmagnetic and vacuum compatible, compared to conventional electromagnetic motors. Improvements in the design of medical equipment for better streamlined functionality and performance are influenced by research, design, modeling, testing, prototyping, and U.S. FDA and EU approvals of new mechatronic devices, or the integration of changes to existing designs. These usually represent a sizable capital investment of resources well before the equipment goes into serial production. Design considerations ... (Read Full Article)

      Comment on Article

    17. Combined image-processing algorithms for improved optical coherence tomography of prostate nerves

      Explore Article SPIE Digital Library (Aug 20 2010) Urology

      Combined image-processing algorithms for improved optical coherence tomography of prostate nerves Cavernous nerves course along the surface of the prostate gland and are responsible for erectile function. These nerves are at risk of injury during surgical removal of a cancerous prostate gland. In this work, a combination of segmentation, denoising, and edge detection algorithms are applied to time-domain optical coherence tomography (OCT) images of rat prostate to improve identification of cavernous nerves. First, OCT images of the prostate are segmented to differentiate the cavernous nerves from the prostate gland. Then, a locally adaptive denoising algorithm using a dual-tree complex wavelet transform is applied to reduce speckle noise. Finally, edge detection is ... (Read Full Article)

      Comment on Article Mentions:   Nathaniel M. Fried   Shahab Chitchian   Johns Hopkins University

    18. Parametric imaging of cancer with optical coherence tomography

      Explore Article SPIE Digital Library (Aug 19 2010) Oncology

      Parametric imaging of cancer with optical coherence tomography We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images. (Read Full Article)

      Comment on Article Mentions:   University of Western Australia   Steven L. Jacques   Loretta Scolaro

    19. Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography

      Explore Article The Journal of Urology (Aug 17 2010) Oncology , Urology

      Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography Purpose: We examined the usefulness of 3-dimensional optical coherence tomography to enhance the diagnosis of urothelial carcinoma in situ.Materials and Methods: By expressing SV40T antigen with uroplakin II promoter, carcinoma in situ readily develops in SV40T transgenic mice at about ages 8 to 20 weeks and then frank high grade papillary carcinoma develops in bladder epithelium. We examined 10 control and 40 SV40T mice during weeks 8 to 20 after birth by parallel en face white light imaging and 3-dimensional optical coherence tomography, and compared results with histology findings. We applied quantitative analysis of computer aided detection to 3-dimensional tomography ... (Read Full Article)

      Comment on Article Mentions:   SUNY at Stony Brook   Yingtian Pan

    20. The Vulnerable Atherosclerotic Plaque: Scope of the Literature

      Explore Article Annals of Internal Medicine (Aug 17 2010) Cardiology

      The Vulnerable Atherosclerotic Plaque: Scope of the Literature The scope of recent literature on the concept of “vulnerable plaque” was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial denudation, fissured cap, severe stenosis, or combinations of these findings. In 242 primary studies, histopathology, biomarkers and imaging of carotid and coronary artery plaques were evaluated for features suggestive of vulnerability. Notably, 89% of these studies were cross-sectional in design and exclusively conducted in patients with known cardiovascular disease. None of the imaging ... (Read Full Article)

      Comment on Article Mentions:   Tufts University

    21. See all featured articles >>

  3. Recent Articles From Around The Web

    1. Fundus oculi observation device, a fundus oculi image display device and a fundus oculi image display method

      Explore Article uspto.gov (Aug 31 2010) Ophthalmology , Patents

      Fundus oculi observation device, a fundus oculi image display device and a fundus oculi image display method A fundus oculi observation device comprises: a first image forming part for optically obtaining data and then forming a fluorescence image of a fundus oculi of an eye administered with a fluorescent agent in advance based on the obtained data; a second image forming part for optically obtaining data and then forming a tomographic image of the fundus oculi based on the obtained data; a display; and a controller for causing said display to display said fluorescence image formed by said first image forming part side-by-side with said tomographic image formed by said second image forming part, as well as ... (Read Full Article)

      Comment on Article Mentions:   Topcon Medical Systems

    2. Optical fiber and broadband light source

      Explore Article uspto.gov (Aug 31 2010) Patents , Broadband Sources

      Optical fiber and broadband light source An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area ... (Read Full Article)

      Comment on Article

    3. Miniaturized imaging device including utility aperture and SSID

      Explore Article uspto.gov (Aug 31 2010) Patents

      Miniaturized imaging device including utility aperture and SSID The present invention is drawn toward miniaturized imaging devices. In one embodiment, the device can include a utility guide having at least one aperture configured for supporting utilities, and an SSID carried by the utility guide. The SSID can include an imaging array on a top surface, and a conductive element on a side surface, wherein the imaging array is electrically coupled to the conductive element. Further, a lens can be optically coupled to the imaging array, and an umbilical, including a conductive line, can be carried by the at least one aperture. The conductive line can be electrically coupled ... (Read Full Article)

      Comment on Article

    4. Catheter device with a position sensor system for treating a vessel blockage using image monitoring

      Explore Article uspto.gov (Aug 31 2010) Cardiology , Patents

      Catheter device with a position sensor system for treating a vessel blockage using image monitoring The invention relates to a catheter device, with a position sensor system, for treatment of a partial or complete vessel blockage under image monitoring, with the catheter device featuring a treatment catheter of a vessel blockage, especially by removal or destruction of plaque and/or expansion of the vessel, which is embodied as an integrated unit, especially as a combination catheter, with an OCT catheter and an IVUS catheter for image monitoring and with the position sensor system. (Read Full Article)

      Comment on Article Mentions:   Siemens

    5. Evaluation of optical coherence tomography findings in age-related macular degeneration: a reproducibility study of two independent reading centres

      Explore Article BJO Online (Aug 30 2010) Ophthalmology

      Evaluation of optical coherence tomography findings in age-related macular degeneration: a reproducibility study of two independent reading centres Background/aims To determine the reproducibility among readers of two independent certified centres, the Vienna Reading Center (VRC) and the University of Wisconsin-Madison Reading Center (UW-FPRC) for optical coherence tomography (OCT) images in age-related macular degeneration (AMD). Methods Fast macular thickness scans and 6 mm cross hair scans were obtained from 100 eyes with all subtypes of AMD using Stratus OCT. Consensus readings were performed by two certified OCT readers of each reading center using their grading protocol. Common variables of both grading protocols, such as presence of cystoid spaces, subretinal fluid, vitreomacular traction and retinal pigment epithelial detachment, were compared ... (Read Full Article)

      Comment on Article Mentions:   University of Wisconsin   Medical University of Vienna   Zeiss Stratus OCT

    6. Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia

      Explore Article BJO Online (Aug 30 2010) Ophthalmology

      Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia Aim To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. Methods Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 and MM7 scan). The sensitivity and specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Area under the receiver operator characteristic (AUROC) curves were generated to assess the ability of each parameter to detect glaucomatous changes. Results 73 normal controls and 77 glaucoma ... (Read Full Article)

      Comment on Article Mentions:   University of Ulsan   Optovue RTVue-100   Yonsei University

    7. Advances in Diagnostic Bronchoscopy

      Explore Article ajrccm.atsjournals.org (Aug 28 2010) Pulmonology

      Advances in Diagnostic Bronchoscopy Diagnostic bronchoscopy has undergone two major paradigm shifts in the last 40 years. First, the advent of flexible bronchoscopy gave chest physicians improved access to the tracheobronchial tree with a rapid learning curve and greater patient comfort compared with rigid bronchoscopy. The second paradigm shift has evolved over the last 5 years with the proliferation of new technologies that have significantly enhanced the diagnostic capabilities of flexible bronchoscopy compared with traditional methods. At the forefront of these new technologies is endobronchial ultrasound. In its various forms, endobronchial ultrasound has improved diagnostic yield for pulmonary masses, nodules, intrathoracic adenopathy, and disease ... (Read Full Article)

      Comment on Article

    8. A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials

      Explore Article Oxford Journals (Aug 27 2010) Neurology , Ophthalmology

      A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials Following an episode of optic neuritis, thinning of the retinal nerve fibre layer, which indicates axonal loss, is observed using optical coherence tomography. The longitudinal course of the retinal changes has not been well characterized. We performed a serial optical coherence tomography study in patients presenting with optic neuritis in order to define the temporal evolution of retinal nerve fibre layer changes and to estimate sample sizes for proof-of-concept trials of neuroprotection using retinal nerve fibre layer loss as the outcome measure. Twenty-three patients (7 male, 16 female, mean age 31 years) with acute clinically isolated unilateral optic neuritis were ... (Read Full Article)

      Comment on Article Mentions:   University College London

    9. Advice for Students Interested in Optics and Photonics from Leaders in the Optics and Photonics Community

      Explore Article YouTube (Aug 27 2010) Jobs & Studentships

      Advice for Students Interested in Optics and Photonics from Leaders in the Optics and Photonics Community SPIE asked leaders in the optics and photonics community to give some advice to students interested in the field. Astronomers, professors, CEOs, a Nobel Prize winner, and others all give their answer to the question, "What advice would you give to a student or young professional interested in optics and/or photonics?" This is a small collection of their responses (Read Full Article)

      Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Oregon Health & Science University

    10. Jim Fujimoto talks about biophotonics and optical coherence tomography

      Explore Article YouTube (Aug 26 2010)

      Jim Fujimoto talks about biophotonics and optical coherence tomography James. G. Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT). The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT). The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT. Fujimoto's area of research involves the development and application of femtosecond laser technology, studies of ultrafast phenomena, and laser medicine and surgery. He is chair of the annual Biomedical ... (Read Full Article)

      Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto

    11. Free Use of OCT Imaging System for One Month Sponsored by Thorlabs and OCT News

      Explore Article Optical Coherence Tomography News (Aug 26 2010)

      Thorlabs, in collaboration with OCT News, is pleased to offer FREE use of a 1300 nm Swept Source OCT Imaging System for one month to two qualified research groups. Thorlabs is dedicated to promoting photonics-based research around the world and has a long history of collaborating with and supporting academic and other non-profit institutions. Our mission is to help advance the photonics industry by providing optical products inspired by true customer needs. We also have a rapidly growing family of imaging-related products including a variety of OCT imaging systems. In particular, Thorlabs' best selling OCT system is the OCS1300SS Swept ... (Read Full Article)

      Comment on Article Mentions:   Thorlabs

    12. Postdoctoral Research Associate in Optical Engineering : Vanderbilt University, Nashville, TN

      Explore Article Optical Coherence Tomography News (Aug 25 2010) Jobs & Studentships

      Postdoctoral Research Associate in Optical Engineering : Vanderbilt University, Nashville, TN Science jobs from Vanderbilt University Department of Biomedical Engineering: Description:Applications are invited for a Postdoctoral research Associate position in the Department of Biomedical Engineering at Vanderbilt University. The objective of our research is to engineer imaging techniques for the quantitative assessment of molecular and hemodynamic changes associated with oncogenesis and cancer progression. The Postdoctoral Research Associate will be involved in the development and application of optical coherence tomography (OCT) systems for pre-clinical studies and will work in collaboration with engineers and biologists. The applicant will have access to state-of-the-art resources in biomedical photonics. This position will also provide a unique ... (Read Full Article)

      Comment on Article Mentions:   Melissa C. Skala

    13. Optical Coherence Tomography for Corneal Diseases

      Explore Article LWW Online (Aug 25 2010) Ophthalmology

      Optical Coherence Tomography for Corneal Diseases Anterior segment optical coherence tomography (OCT) is currently used for investigating the distribution of the corneal thickness, shape of the stromal interface after lamellar corneal surgery, association between host and corneal graft in keratoplasty, dimension of the anterior chamber, and lesions of the corneal diseases. In addition, the advances of OCT technology has enabled three-dimensional imaging, tissue imaging, cell imaging, and topographic analysis. In this review, examples of tissue imaging with 840-nm spectral-domain OCT, cell imaging with full-field OCT, and corneal topographic analysis with 1,310-nm swept-source OCT were introduced. (Read Full Article)

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    14. Relationship Between Arterial and Fibrous Cap Remodeling: A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study

      Explore Article Circulation (Aug 25 2010) Cardiology

      Relationship Between Arterial and Fibrous Cap Remodeling: A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study Background—Positive arterial remodeling and thin fibrous cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the fibrous cap thickness and the relationship between serial arterial remodeling and changes in fibrous cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in fibrous cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results—Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 ... (Read Full Article)

      Comment on Article Mentions:   Stanford University   Hiroyuki Okura   Teruyoshi Kume

    15. Evaluation of stent placement and outcomes with optical coherence tomography

      Explore Article futuremedicine.com (Aug 25 2010) Cardiology

      Evaluation of stent placement and outcomes with optical coherence tomography Optical coherence tomography (OCT) is an imaging modality based on fiberoptic technology. OCT imaging systems use optical imaging catheters that emit near-infrared light to produce high resolution, real-time images. The frequencies and bandwidths of infrared light are far higher than medical ultrasound signals, resulting in greatly increased image resolution, which is approximately ten-times higher than that of intravascular ultrasound. Compared with conventional imaging modalities, OCT is superior for the evaluation of vulnerable plaque features, which may be associated with a higher risk of peri-interventional myocardial infarction, such as plaque rupture, thrombus, thin-capped fibroatheroma and macrophages within the fibrous caps. OCT ... (Read Full Article)

      Comment on Article Mentions:   Junya Shite   Toshiro Shinke   Kobe University Graduate School of Medicine

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