1. Feature Of The Week

    Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia.

    Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people.

    Design, Setting, and Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. The pilot study phase was conducted from March 2006 to June 2006, and the main cohort underwent examination for baseline measures from April 2007 to October 2010. Four basic cognitive tests were performed at baseline, which were then repeated in a subset of participants approximately 3 years later. We analyzed eyes with high-quality optical coherence tomography images, excluding those with eye disease or vision loss, a history of ocular or neurological disease, or diabetes. We explored associations between RNFL thickness and cognitive function using multivariable logistic regression modeling to control for demographic as well as physiologic and ocular variation.

    Main Outcomes and Measures: Odds ratios (ORs) for cognitive performance in the lowest fifth percentile in at least 2 of 4 cognitive tests at baseline, or worsening results on at least 1 cognitive test at follow-up. These analyses were adjusted for age, sex, race/ethnicity, height, refraction, intraocular pressure, education, and socioeconomic status.

    Results: A total of 32 038 people were included at baseline testing, for whom the mean age was 56.0 years and of whom 17 172 (53.6%) were women. A thinner RNFL was associated with worse cognitive performance on baseline assessment. A multivariable regression controlling for potential confounders showed that those in the thinnest quintile of RNFL were 11% more likely to fail at least 1 cognitive test (95% CI, 2.0%-2.1%; P = .01). Follow-up cognitive tests were performed for 1251 participants (3.9%). Participants with an RNFL thickness in the 2 thinnest quintiles were almost twice as likely to have at least 1 test score be worse at follow-up cognitive testing (quintile 1: OR, 1.92; 95% CI, 1.29-2.85; P < .001; quintile 2: OR, 2.08; 95% CI, 1.40-3.08; P < .001).

    Conclusions and Relevance: A thinner RNFL is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline. This preclinical observation has implications for future research, prevention, and treatment of dementia.

    The research took place at the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology.

    For more information see recent Article. Courtesy Praveen Patel from Moorfields Eye Hospital and the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and the UCL Institute of Ophthalmology. To share this article click Here.

  2. Recent Articles From Around The Web

    1. Late clinical outcome of suboptimal stent implantation defined by intracoronary optical coherence tomography

      Late clinical outcome of suboptimal stent implantation defined by intracoronary optical coherence tomography

      Optical coherence tomography (OCT) is an intravascular imaging technique that provides high-resolution (10-20 μm) images. During percutaneous coronary intervention (PCI), OCT offers useful information to guide treatment strategies and assess optimal stent implantation (Figure 1) . However, OCT remains markedly underused in the real world. For further integration of OCT into clinical practice, it is necessary to accumulate evidence showing that OCT has a beneficial impact on the outcomes of PCI. In 2012 and 2015, Prati et al 1,2 reported the clinical benefits of OCT guidance in PCI using data

      Read Full Article
    2. MULTIMODAL IMAGING OF MACULAR CHOROIDAL MACROVESSEL: A REPORT OF TWO CASES

      MULTIMODAL IMAGING OF MACULAR CHOROIDAL MACROVESSEL: A REPORT OF TWO CASES

      Purpose: To report two cases of macular choroidal macrovessel with description of multimodal imaging and review of published cases. Methods: Medical and imaging records were retrospectively reviewed. A literature review was performed to identify other cases of macular choroidal macrovessel published between 1990 and 2018. Results: There were 2 patients referred for evaluation of a potential choroidal tumor , including a 55-year-old white woman with no visual symptoms and a 68-year-old white woman with blurred vision. Funduscopic examination in each case revealed a focal area of choroidal elevation in the temporal foveal area with a single, dilated, slightly tortuous choroidal vessel ...

      Read Full Article
    3. Choroidal Thickness Changes Following Vitrectomy in Epiretinal Membrane Based on the Optical Coherence Tomography Pattern

      Choroidal Thickness Changes Following Vitrectomy in Epiretinal Membrane Based on the Optical Coherence Tomography Pattern

      Purpose To analyze the influence of morphological classification in epiretinal membrane (ERM) based on surgical outcomes and optical coherence tomography (OCT) of the postoperative choroidal thickness. Methods This observational study included 122 eyes with ERM who underwent vitrectomy. Using OCT, the preoperative ERM was classified into six types: cystoid macular edema (CME), convex, flat, normal foveal contour (Normal), pseudolamellar hole (PLH), and vitreomacular traction (VMT). The preoperative multifocal electroretinogram (mfERG), postoperative change in subfoveal choroidal thickness (SCT), central macular thickness (CMT), and best-corrected visual acuity (BCVA) were compared. Results Preoperative subfoveal choroidal thickness increased in the VMT type compared to ...

      Read Full Article
    4. Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine

      Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine

      Objective: This study aimed to compare, using optical coherence tomography (OCT), the outcomes of bioabsorbable drug-eluting stent with those of bare metal stent (BMS) following implantation in porcine iliac artery. Methods: After the placement of BMS and bioabsorbable drug-eluting stents, we used OCT and digital subtraction angiography to investigate stent appositions, arterial neointima, evagination, and restenosis at 1 and 3 months. Results: At 1 and 3 months after stent implantation, OCT study was performed to investigate 32 stents and 21 788 struts. Thirty-three malapposed struts were found in the bioabsorbable drug-eluting stent groups and 2 were found in BMS groups ...

      Read Full Article
    5. Comparison of Anterior Segment Measurements between Scheimpflug Camera and New Module of Optical Coherence Tomography

      Comparison of Anterior Segment Measurements between Scheimpflug Camera and New Module of Optical Coherence Tomography

      Purpose We compared the anterior segment measurements using a Scheimpflug camera (Pentacam® [Oculus Inc., Wetzlar, Germany]) and a new anterior segment module of optical coherence tomography (Cirrus HD-OCT 5000® [Carl Zeiss Meditec, Dublin, CA, USA]). Methods Anterior segment measurements were evaluated in 47 eyes of 26 patients who visited for the purpose of cataract surgery. Measurements of the central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber angle (ACA; nasal and temporal side), and angle to angle distance (ATA) were compared between the Pentacam® and the new anterior segment module of the Cirrus HD-OCT 5000®. Results The mean CCTs ...

      Read Full Article
    6. Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography

      Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography

      Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography (OCTA) based on optical microangiography (OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA (Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density (VAD), vessel skeleton density (VSD), vessel diameter index (VDI), vessel ...

      Read Full Article
    7. Anterior Segment Optical Coherence Tomography Analysis of Iris Morphometric Changes Induced by Prostaglandin Analogues Treatment in Patients with Primary Open Angle Glaucoma or Ocular Hypertension

      Anterior Segment Optical Coherence Tomography Analysis of Iris Morphometric Changes Induced by Prostaglandin Analogues Treatment in Patients with Primary Open Angle Glaucoma or Ocular Hypertension

      Background: The study aimed to evaluate iris thickness changes in patients with Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) under treatment with Prostaglandin Analogues (PG). Objectives: Primary outcome measures were iris thickness at the region of Dilator Muscle Region (DMR) and Sphincter Muscle Region (SMR). DMR/SMR ratio was also evaluated. The secondary outcome was the correlation between PG treatment length and iris parameters. Methods: The charts of patients with POAG or OHT who underwent Visante OCT were retrospectively selected. The patients were divided in a group using PG for at least 6 months and a group using ...

      Read Full Article
    8. Differences in coronary plaque morphology between East Asian and Western White patients: an optical coherence tomography study

      Differences in coronary plaque morphology between East Asian and Western White patients: an optical coherence tomography study

      Aims Prevalence of coronary artery disease as well as cardiac mortality varies between Asian and White patients. However, the link between race and plaque characteristics in patients with coronary artery disease remains largely unexplored. Thus, we aimed to investigate the detailed culprit plaque characteristics between East Asian and White patients using optical coherence tomography . Patients and methods A total of 101 East Asians were matched to 101 White patients. Matching parameters included age, sex, clinical presentation, hyperlipidemia, diabetes mellitus, and lesion location. Results There were no differences in underlying pathology (rupture vs. erosion) of acute coronary syndrome ( P =0.935 ...

      Read Full Article
    9. Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment

      Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment

      Background To describe the patterns and outcomes of contusion maculopathy after ocular contusions resulting from accidental impact with sporting equipment. Methods We conducted a retrospective study of interventional case series. Patient Population: Twenty-one eyes of 21 patients who sustained blunt ocular trauma while playing a sport. Intervention/Observation Procedure(s): Surgery or observation by optical coherence tomography (OCT). Main Outcome Measure(s): The morphologic changes within the macula in the early stages after injury and changes in visual function in the early and recovery stages after injury. Results In the early stage, OCT visualized four injury patterns: type Ι, commotio retinae ...

      Read Full Article
      Mentions: Gunma University
    10. ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions

      ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions

      Purpose: To assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of diabetic retinopathy with optical coherence tomography angiography and central visual analyzer. Methods: This was an observational case–control study of diabetic patients without diabetic retinopathy and nondiabetic controls. Patients underwent optical coherence tomography angiography imaging and visual acuity testing using the central visual analyzer. The foveal avascular zone area and the capillary density in the superficial and deep capillary plexuses were measured manually by a masked grader. Results: Sixty eyes from 35 diabetic patients were included in the study group, and 45 eyes from ...

      Read Full Article
    11. SENSITIVITY OF 840-nm SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN DETECTING TYPE 1 NEOVASCULARIZATION ACCORDING TO THE HEIGHT OF THE ASSOCIATED PIGMENT EPITHELIAL DETACHMENT

      SENSITIVITY OF 840-nm SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN DETECTING TYPE 1 NEOVASCULARIZATION ACCORDING TO THE HEIGHT OF THE ASSOCIATED PIGMENT EPITHELIAL DETACHMENT

      Purpose: To evaluate the ability of optical coherence tomography angiography (OCTA) to detect abnormal vascular blood flow in Type 1 neovascularization (NV) with or without significant pigment epithelial detachment (PED). Methods: Consecutive age-related macular degeneration patients with either treatment-naive or anti–vascular endothelial growth factor–treated Type 1 NV were divided into 2 groups based on the PED height on structural OCT: greater than 250 μ m (Group 1) versus less than 250 μ m (Group 2). Two independent senior retina specialists analyzed the OCTA images (Zeiss Angioplex OCT, Carl Zeiss AG, Jena, Germany) using the automatic slabs alone (first reader) versus ...

      Read Full Article
    12. Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

      Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

      Objectives The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography . Background In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. Methods Angiography and intravascular optical coherence tomography were used to investigate etiologic factors of neoatherosclerosis in patients presenting with stent thrombosis >1 year after implantation (very late stent thrombosis [VLST]). Clinical data were collected according to a standardized protocol. Optical coherence tomographic acquisitions were analyzed in a core laboratory. Cox regression analysis was performed to identify factors associated ...

      Read Full Article
    13. Quantitative Comparison of Retinal Vascular Features in Optical Coherence Tomography Angiography Images From Three Different Devices

      Quantitative Comparison of Retinal Vascular Features in Optical Coherence Tomography Angiography Images From Three Different Devices

      BACKGROUND AND OBJECTIVE: To compare optical coherence tomography angiography (OCTA) images from three different devices. PATIENTS AND METHODS: This was a prospective, observational, cross-sectional study. All eyes (n = 24) were imaged thrice each time with swept-source OCT (DRI OCT Triton Plus; Topcon, Tokyo, Japan), spectral-domain OCTA (AngioVue; Optovue, Fremont, CA), and SD-OCT Angioplex (Cirrus HD-OCT 5000; Carl Zeiss Meditec, Jena, Germany). Outcome measures were foveal avascular zone (FAZ) area, vessel density, spacing between large vessels (SLV), and spacing between small vessels (SSV). They were calculated using local fractal analyses and Frangi filter. RESULTS: The vascular parameters showed good to excellent ...

      Read Full Article
    14. Heidelberg Engineering Prepares Leadership Team for the Future

      Heidelberg Engineering Prepares Leadership Team for the Future

      Heidelberg Engineering GmbH announced today changes to the leadership team responsible to consistently deliver the company’s brand promise of excellence and innovation, supported by knowledge and confidence. Having worked alongside the founders Dr. Gerhard Zinser and Christoph Schoess for over 23 years, Dr. Tilman Otto will continue to lead R&D. New to the leadership team, Ali Tafreshi who has served in sales, marketing and research capacities in both the US and German organizations for 6 years, will head up Product Management and Clinical Affairs. Dr. Gerhard Zinser carefully handpicked this powerful combination of technical and clinical talent to ...

      Read Full Article
    15. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (2 articles) Capital Medical University
    2. (2 articles) University of Washington
    3. (1 articles) Harvard University
    4. (1 articles) Massachusetts General Hospital
    5. (1 articles) Imperial College London
    6. (1 articles) Kyung Hee University
    7. (1 articles) Royal Brompton Hospital
    8. (1 articles) New York Eye and Ear Infirmary
    9. (1 articles) University of Bonn
    10. (1 articles) National Yang-Ming University
  3. People in the News

    1. (2 articles) Carlo Di Mario
    2. (1 articles) Dirk-Uwe G. Bartsch
    3. (1 articles) Frank G. Holz
    4. (1 articles) Joseph Carroll
    5. (1 articles) Masamichi Takano
    6. (1 articles) Robert A. Byrne
    7. (1 articles) Tom Adriaenssens
    8. (1 articles) Christos V. Bourantas
    9. (1 articles) Michael Joner
    10. (1 articles) Ik-Kyung Jang
    11. (1 articles) Wen-Chuan Kuo
    12. (1 articles) Richard B. Rosen
    13. (1 articles) Hang Lee
    14. (1 articles) William R. Freeman
    15. (1 articles) Ole Massow
  4. OCT Companies in the News

    1. (5 articles) Carl Zeiss Meditec
    2. (2 articles) Optovue
    3. (1 articles) Thorlabs
    4. (1 articles) Topcon Medical Systems
    5. (1 articles) Heidelberg Engineering
    6. (1 articles) Canon Medical Systems
  5. Picture Gallery

    Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance? Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography Wasatch Photonics extends Cobra OCT spectrometer product line to shorter wavelengths and greater depths Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography Three-dimensional graph-based skin layer segmentation in optical coherence tomography images for roughness estimation Two PhD Studentships in Medical Physics & Biomedical Engineering at the University College London Coronary Artery Intraplaque Microvessels by Optical Coherence Tomography Correlate With Vulnerable Plaque and Predict Clinical Outcomes in Patients With Ischemic Angina Late clinical outcome of suboptimal stent implantation defined by intracoronary optical coherence tomography
  6. Recent Quotes

    1. The Ganymede series has proven to be an excellent tool for a multitude of imaging applications,...The Thorlabs OCT application team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    2. I am honored and incredibly excited to take on this leadership role during such a pivotal point in the company’s history and look forward to working with Merit Medical on our new strategic partnership. I would like to extend my sincere thanks to Chris for his service to NinePoint and mentorship to me over the past four-years. I am fortunate to be surrounded by a truly talented team with exciting and innovative products in the pipeline. Together, we look forward to continuing our important mission towards early detection of cancer.
      By Eman Namati
    3. We are thrilled to receive marketing clearance for our innovative AngioAnalytics technology as part of the AngioVue System to aid physicians in the early detection and management of sight-threatening eye diseases in the U.S.,” said Jay Wei, founder and chief executive officer of Optovue. “Analytic measurement tools will shift the treatment paradigm because they provide an objective measure of treatment efficacy, thereby enabling truly customized patient management and improved patient care...The information provided by AngioAnalytics may help to change the clinical management of diabetic retinopathy, age-related macular degeneration and other diseases that progressively cause blindness for millions of people. We will continue to advance AngioAnalytics as we believe quantification is the gateway to widespread and global adoption of OCTA.
      By Jay Wei
    4. This is the world's first intravascular imaging system for clinical use with the capability to acquire both IVUS and OCT images using a single catheter. IVUS and OCT are the two most commonly used intravascular imaging technologies in addition to angiography...The Novasight Hybrid System provides the resolution and contrast of OCT with the larger field of view of IVUS, and displays the images in a precisely co-registered fashion.
      By Brian K. Courtney
    5. We started with middle ear infections because of our personal experience with this disease as both parents and patients. Our novel application of optical coherence tomography revolutionizes the diagnosis, treatment and monitoring of the middle ear infections that affect 80% of children.
      By Ryan L. Shelton
    6. With the assistance of the next generation Pantheris system, we helped restore blood flow within the previously blocked segment of the artery and most importantly achieved a great outcome for the patient.
      By Arne G. Schwindt
    7. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen
    8. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    9. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    10. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei