1. Feature Of The Week

    OCT_Edit is a Matlab program with a graphical interface used to edit optical coherence tomography images. It works with raw k-clocked sample files, rather than bitmap images directly. Because of this, it can do background subtraction and dispersion compensation to create new sample files with a minimum loss of information. Windowing functions, color maps, black and white level cropping can be tried out very quickly.

    Watching the video tutorial within the presentation is the easiest way to learn about the capabilities of OCT_Edit.
    The editor source code and example image files are available for free upon request. Please email us at info@axsun.com.

    Courtesy Bart Johnson from Axsun Technologies.. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Blood flow changes are highly related to neural activities in the retina. It has been reported that neural activity increases when flickering light stimulation of the retina is used. It is known that blood flow changes with flickering light stimulation can be altered in patients with vascular disease and that measurement of flicker-induced vasodilatation is an easily applied tool for monitoring functional microvascular alterations. However, details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood due to the limitation of existing techniques. In this study, flickering light stimulation was applied to mouse retinas to ...

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      Mentions: Xincheng Yao
    2. Ultrathin forward-imaging short multimode fiber probe for full-field optical coherence microscopy

      Ultrathin forward-imaging short multimode fiber probe for full-field optical coherence microscopy

      To extend the applications of optical coherence tomography (OCT) to the fields of physiology and clinical medicine, less invasive, robust, and reliable optical probes are required. Thus, we demonstrate an ultrathin forward-imaging short multimode fiber (SMMF) optical coherence microscopy (OCM) probe with a 50 μm core diameter, 125 μm total diameter, and 5.12 mm length. Imaging conditions and magnification were analyzed, and they correspond closely to the measured results. The dispersion of the SMMF was investigated, and the modal dispersion coefficient was found to be 2.3% of the material dispersion coefficient. The axial resolution was minimized at 2 ...

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    3. Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression

      Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression

      Purpose : We assessed the application of the choroidal vascularity index (CVI) in the follow-up of Vogt-Koyanagi-Harada disease (VKH) patients derived from image binarization of enhanced depth imaging optical coherence tomography (EDI-OCT) images with Fiji software. Our secondary objective was to derive the retinochoroidal vascularity index based on en face fundus fluorescein and indocyanine green angiography (FFA and ICGA). Methods : In this retrospective cohort study, EDI-OCT scans of 18 eyes of 9 patients with VKH were obtained at baseline within 2 weeks of acute presentation, and again at 6 to 12 months. Images with poor quality were excluded. Choroidal thickness (CT ...

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    4. Volumetric Image Classification using Homogeneous Decomposition and Dictionary Learning: A Study Using Retinal Optical Coherence Tomography for Detecting Age-related Macular Degeneration

      Volumetric Image Classification using Homogeneous Decomposition and Dictionary Learning: A Study Using Retinal Optical Coherence Tomography for Detecting Age-related Macular Degeneration

      Three-Dimensional (3D) (volumetric) diagnostic imaging techniques are indispensable with respect to the diagnosis and management of many medical conditions. However there is a lack of automated diagnosis techniques to facilitate such 3D image analysis (although some support tools do exist). This paper proposes a novel framework for volumetric medical image classification founded on homogeneous decomposition and dictionary learning. In the proposed framework each image (volume) is recursively decomposed until homogeneous regions are arrived at. Each region is represented using a Histogram of Oriented Gradients (HOG) which is transformed into a set of feature vectors. The Gaussian Mixture Model (GMM) is ...

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    5. Post-Mortem Corneal Thickness Measurements with a Portable Optical Coherence Tomography System: a Reliability Study

      Post-Mortem Corneal Thickness Measurements with a Portable Optical Coherence Tomography System: a Reliability Study

      The purpose of this study was to determine the repeatability and reproducibility of post-mortem central corneal thickness (CCT) measurements by using a real-time, portable optical coherence tomography (OCT) system on an animal model, and to prospectively evaluate the time-course of post-mortem changes in CCT. Forty-six ocular globes of sheep ( Ovis aries ) were analyzed with a portable spectral-domain OCT device by two operators at different postmortem intervals (PMIs) as follows: immediately (i.e. within 10 minutes), at the 30 th minute, at the 1 st , 6 th , 12 th , 24 th and 48 th hour, and later (up to the 96 ...

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    6. Retinal nerve fiber and optic disc morphology using spectral-domain optical coherence tomography in scleroderma patients

      Retinal nerve fiber and optic disc morphology using spectral-domain optical coherence tomography in scleroderma patients

      To evaluate the optic nerve head parameters and peripapillary retinal nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in a systemic sclerosis (SSc) cohort and age-matched controls to determine whether SSc patients have an increased risk of normal-tension glaucoma (NTG). We examined 30 patients (3 male, 27 female) with SSc and 28 age- and sex-matched controls. Retinal nerve fiber and optic disc morphology were evaluated using Cirrus SD-OCT. Optic disc morphology measurements including disc area, rim area, average and vertical cup/disc (C/D) ratio, and cup volume were not significantly different between the study groups. The average and ...

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    7. Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optic disc cavernous haemangiomas are either found incidentally or after presentation with vitreous haemorrhage. They are characterised by a cluster of grapes appearance to the multiple vascular saccules that make up the tumour. They are more often found in the retinal periphery but rarely occur at the optic disc. Optical coherence tomography (OCT) imaging may be a useful non-invasive imaging modality to follow-up these lesions. We present the case of an asymptomatic 60-year-old lady referred from her optometrist with a lesion overlying the optic disc and the ensuing diagnosis of cavernous haemangioma using fundus fluorescein angiography and OCT.

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    8. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Aims The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score , and explored its association with the prevalence of HRPs and clinical outcomes. Methods and results A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT. ESS was calculated using computational fluid dynamics and classified into low, moderate, and high in 3-mm-long subsegments. In each subsegment ...

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    9. High-resolution and nondestructive profile measurement by spectral-domain optical coherence tomography with a visible broadband light source for optical-device fabrication

      High-resolution and nondestructive profile measurement by spectral-domain optical coherence tomography with a visible broadband light source for optical-device fabrication

      We developed a spectral-domain optical coherence tomography (OCT) using a visible broadband light source (vis-OCT) for application to high-resolution and nondestructive profile measurement and imaging in semiconductor optical-device fabrication. By using visible broadband light centered at 625 nm and with spectral bandwidth of 260 nm, an axial resolution of 0.69 µm in air was obtained. This was effective for inspection of a transparent photoresist film with thickness of 1–2 µm coated on a semiconductor wafer; the interface between the photoresist film and its substrate and the interface between the photoresist and air were resolved, and the film thickness ...

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    10. Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography

      Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography

      Purpose : We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA). Methods : A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of these patients were compared to those from indocyanine green angiography (ICGA). Semiautomated segmentation was used to further analyze the polypoidal lesion and the BVN. Results : We studied 13 eyes of ...

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    11. Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Physical Sciences Incorporated Receives a 2016 NIH Grant for $475,423 for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2011 and ends in 2017. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Caliber Imaging & Diagnostics Inc. (Caliber ID), proposes to develop a hand-held reflectance confocal microscopy - optical coherence tomography (RCM-OCT) imaging probe and clinically evaluate its potential use for guiding laser ablation therapy of BCC basal cell carcinoma (BCC). While RCM provides en ...

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    12. Brigham and Women's Hospital Receives a NIH Grant for Aortic Valve Microcalicifacation

      Brigham and Women's Hospital Receives a NIH Grant for Aortic Valve Microcalicifacation

      Brigham and Women's Hospital Receives a 2016 NIH Grant for $415,740 for Aortic Valve Microcalicifacation. The principal investigator is Elena Aikawa. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of valvular interstitial cell (VIC)-derived matrix vesicles, precursors of microcalcification, offering the novel mechanism of calcific aortic valve disease (CAVD). Our pilot studies showed that S100A9 - a recently identified biomarker of acute cardiovascular events - is expressed by VIC and a component of ...

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    13. Role of Tractional Forces and Internal Limiting Membrane in Macular Hole Formation: Insights from Intraoperative Optical Coherence Tomography

      Role of Tractional Forces and Internal Limiting Membrane in Macular Hole Formation: Insights from Intraoperative Optical Coherence Tomography

      We report the case of a 69-year-old patient who underwent vitrectomy for vitreomacular traction (VMT) and developed a postoperative macular hole that was observed 1 week after surgery. The hole did not close by in-office fluid-gas exchange alone, but was achieved after repeat surgery with internal limiting membrane (ILM) peeling. Intraoperative OCT (iOCT) images from the first surgery revealed an occult macular hole that formed after VMT release. We discuss how iOCT findings provide insight into the role of the ILM in macular hole formation and emphasize the importance of carefully inspecting iOCT images in real time to avoid missing ...

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      Mentions: UC Davis
    14. Swept-Source Optical Coherence Tomography Detecting Intraoperative Acute Descemet's Fold Formation

      Swept-Source Optical Coherence Tomography Detecting Intraoperative Acute Descemet's Fold Formation

      Background: To present an intraoperative acute Descemet’s fold formation using swept-source optical coherence tomography (SS-OCT) imaging. Case Report: A 67-year-old man complaining of reduced visual acuity in the left eye. A 25-gauge pars plana vitrectomy combined with phacoemulsification cataract surgery was performed to remove the vitreomacular traction. When hydro-sealing was performed, striae rapidly spread in the cornea. SS-OCT B-scan images performed on postoperative day 1 revealed a wavy Descemet’s membrane that might correspond to Descemet’s folds. Pairs of hypo- and hyperreflective narrow lesions running from the wavy Descemet’s membrane to almost half of the thickness of ...

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    15. Correlation between central foveal thickness as measured by OCT andHbA1c level in diabetes retinopathy

      Correlation between central foveal thickness as measured by OCT andHbA1c level in diabetes retinopathy

      bjectives: To evaluate the correlation between Glycosylated Haemoglobin (HbA1c) level and central foveal thickness measured by Optical coherence tomography (OCT) in patients with type 2 diabetes mellitus.Materials and methods:This was a retrospective single center study of 6 month duration including patients of pre-proliferative stage of type 2 diabetes mellitus. Clinically significant macular oedema (CSME) was diagnosed by using OCT. OCT examination by ‘RT optovue, Fremont, CA’ and HbA1c measured by specific high-pressure liquid chromatography methods. If patient have both eye macular oedema, eye with thicker macular oedema was used for statistical analysis. Exclusion of patients who received intraocular ...

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      Mentions: Optovue
    16. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
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      Broadband Sources, Probes, Tunable Sources
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      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (2 articles) Tufts University
    2. (2 articles) UCLA
    3. (2 articles) National Institutes of Health
    4. (2 articles) University of Miami
    5. (1 articles) Lehigh University
    6. (1 articles) UC Davis
    7. (1 articles) Kyoto University Graduate School of Medicine
    8. (1 articles) Simon Fraser University
    9. (1 articles) University of Freiburg
    10. (1 articles) Brigham and Women’s Hospital
  3. People in the News

    1. (2 articles) Jay S. Duker
    2. (1 articles) Marinko V. Sarunic
    3. (1 articles) Chao Zhou
    4. (1 articles) Carol L. Shields
    5. (1 articles) Daniël M. de Bruin
    6. (1 articles) Jean J. M. C. H. de la Rosette
    7. (1 articles) Nicolai Brill
    8. (1 articles) Sven Nebelung
    9. (1 articles) Nicolas Foin
    10. (1 articles) Dirk J. Faber
    11. (1 articles) Ton G. van Leeuwen
    12. (1 articles) Daniel S. Fried
    13. (1 articles) Theo M. de Reijke
    14. (1 articles) Robert Schmitt
    15. (1 articles) Sieun Lee
  4. OCT Companies in the News

    1. (2 articles) Optovue
    2. (1 articles) Exalos
    3. (1 articles) Bioptigen
    4. (1 articles) Topcon Medical Systems
    5. (1 articles) Heidelberg Engineering
    6. (1 articles) Leica
    7. (1 articles) Physical Sciences Incorporated
  5. OCT Products in the News

    1. (3 articles) Zeiss Cirrus HD-OCT
    2. (2 articles) Heidelberg Spectralis
    3. (1 articles) Optovue RTVue-100
  6. Picture Gallery

    Loose powder detection and surface characterization in selective laser sintering via optical coherence tomography The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography The Development, Commercialization, and Impact of Optical Coherence Tomography Key Developments for Partial Coherence Biometry and Optical Coherence Tomography in the Human Eye Made in Vienna Optical Coherence Tomography and the Development of Antiangiogenic Therapies in Neovascular Age-Related Macular Degeneration MIT’s 10-Material 3D Printer Heading to Production? Minimal basilar membrane motion in low-frequency hearing Special Issue: 25 Years of Optical Coherence Tomography Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy Quantitative measurement and real-time tracking of high intensity focused ultrasound using phase-sensitive optical coherence tomography: Feasibility study
  7. Recent Quotes

    1. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      By David Huang
    2. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      By Wolfgang Drexler
    3. This gives us a very controlled way of looking at ovarian cancer.
      By Jennifer K. Barton
    4. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      By Jennifer K. Barton
    5. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    6. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
      By Philip J. Rosenfeld
    7. Our goal with MicroAngio is to provide a flexible tool that can be used in an optimal fashion for a wide range of applications...MicroAngio comes with customized probes and fixtures for small animal retinal, dorsal window chamber and brain imaging. We also provide a suite of algorithms for data analysis essential for angiographic imaging.”
      By Nishant Mohan
    8. In the majority of cases it is clinically and dermoscopically possible to differentiate between AK and BCC, but there are difficult situations, especially in early cases or during topical therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear...This data published shows that VivoSight OCT is not only able to differentiate between the two diseases by means of epidermal thickness and signal intensity measurements but also able to be used as a non-invasive technique to determine and monitor the treatment. This technology significantly improves the diagnostic methods currently used resulting in better outcomes for patients.
      By Julia Welzel
    9. We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness...Since we first introduced this technology to markets outside the U.S. fourteen months ago, the technology is in daily clinical use at over 525 clinical sites where it provides a more patient-friendly approach to diseases of the retina that lead to progressive blindness.
      By Jay Wei
    10. In the field of OCT imaging and biometry, size, price and operating power are three critical elements to commercialization in mass market applications...Our MRO system is the first version of OCT with the size, cost and operating power profile to address high volume applications in areas such as mobile personal health monitoring and biometric security.
      By Don Bogue