1. Recent Articles From Around The Web

    1. IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION

      IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION

      n imaging technique developed at the Biophotonics Imaging Laboratory at the Beckman Institute was named one of the 10 best microscopy innovations of 2019 by Microscopy Today, the official magazine of the Microscopy Society of America. Dr. Stephen Boppart, a professor of bioengineering and of electrical and computer engineering Simultaneous label-free autofluorescence multi-harmonic (SLAM) microscopy is a new imaging technology developed by senior research scientist Haohua Tu, bioengineering graduate student Sixian You, and a team of researchers at the Biophotonics Imaging Laboratory, led by Dr. Stephen Boppart, a professor of bioengineering and of electrical and computer engineering at Illinois, and ...

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    2. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives a 2019 NIH Grant for $1,230,507 for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease .The principal investigator is Danny Wang. Below is a summary of the proposed work. While Alzheimer's disease (AD) is the most common cause of dementia, the contribution of vascular factors to cognitive impairment and dementia is becoming increasingly recognized. Vascular cognitive impairment and dementia (VCID) is most commonly caused by cerebral small vessel disease (SVD). To date, cerebral small vessels including arterioles, capillaries and venules are inaccessible to existing imaging technologies. Characteristic parenchymal lesions on ...

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    3. Columbia University Receives NIH Grant for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity

      Columbia University Receives a 2019 NIH Grant for $636,552 for Measures of Human Receptor and post Receptor Activity. The principal investigator is Donald Hood. Below is a summary of the proposed work. Our long-term objective has been to develop noninvasive techniques for studying the human retina for both basic science and clinical purposes. By applying current theories of phototransduction to the full-field electroretinogram (ERG), we successfully developed widely used techniques for studying the global activity of the rod and cone receptors, as well as the rod bipolar cells. These indices of objective retinal function are appropriate outcome measures for ...

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    4. Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation

      Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation

      Purpose : To investigate the pathogenesis of Multiple Evanescent White Dot Syndrome (MEWDS) using multimodal imaging (MMI). Methods : Retrospective case series of 7 patients with acute MEWDS. Each patient underwent: near-infrared reflectance (IR), blue and near-infrared autofluorescence (FAF and NIRAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), enhanced depth imaging optical coherence tomography (EDI-OCT) on Spectralis, and optical coherence tomography angiography on OCTA Spectralis, XR Avanti or Plex Elite 9000. Results : OCTA and FA findings of early hyperfluorescence depict an unaffected choriocapillaris. On ICGA early to late hypofluorescent lesions corresponded to the hyporeflectivity on IR, consistent with altered reflectivity of the ...

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    5. MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION

      MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION

      Purpose: To report a rare case of choroidal neovascularization (CNV) developed 2 years after successful treatment of ocular syphilis , identified by optical coherence tomography angiography . Methods: Case report. Results: A 31-year-old man with a history of syphilitic chorioretinitis developed a CNV 2 years after clinical remission of the infection. Structural optical coherence tomography (OCT) and optical coherence tomography angiography were helpful in providing detailed evidence of an extrafoveal CNV in an easy and noninvasive way. In comparison, the identification of CNV on fluorescein angiography was difficult because of the retinal blood barrier breakdown and intense choroidal background fluorescence for diffuse ...

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    6. Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber

      Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber

      As is generally known, broad-band near-infrared Supercontinuum (SC) is significant for the applications such as pump-probe spectroscopy, nonlinear spectroscopy, frequency combs, or nonlinear optical parametric amplification. We present the first detailed demonstration of approximate near-infrared, octave-spanning SC generation in all-normal dispersion CS2 single-hole liquid core optical fiber (LCOF). By solving the generalized nonlinear Schrödinger equation, the SC at different parameters can be calculated. The influence of important parameters including but not limited to fiber core-diameter, pump wavelength, pump power, and pulse width, on the supercontinuum generation (SCG) of CS2 infiltrated LCOF can be analyzed for optimization of near-infrared SC ...

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    7. Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging

      Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging

      Glioblastoma is a primary malignant brain tumor characterized by highly infiltrative glioma cells. Vasculature and white matter tracts are considered to be the preferred and fastest routes for glioma invasion through brain tissue. In this study, we systematically quantified the routes and motility of the U251 human glioblastoma cell line in mouse brain slices by multimodal imaging. Specifically, we used polarization-sensitive optical coherence tomography to delineate nerve fiber tracts while confocal fluorescence microscopy was used to image cell migration and brain vasculature. Somewhat surprisingly, we found that in mouse brain slices, U251 glioma cells do not follow white matter tracts ...

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    8. Optical Coherence Tomography Angiography in Monitoring Proliferative Macular Telangiectasia Type 2 Treatment Response

      Optical Coherence Tomography Angiography in Monitoring Proliferative Macular Telangiectasia Type 2 Treatment Response

      BACKGROUND AND OBJECTIVE: Difficulty exists in the follow-up of proliferative macular telangiectasia type 2 (MacTel 2) cases after anti-vascular endothelial growth factor (VEGF) treatment due to staining in fluorescein angiography (FA) and alteration in retinal layers by optical coherence tomography (OCT). Herein, the authors report three cases in which OCT angiography (OCTA) could resolve this issue. PATIENTS AND METHODS: In this retrospective, observational case series, diagnosis of MacTel 2 was made based on clinical examination, FA, OCT, and OCTA at presentation. Regression of neovessels was monitored by OCT and OCTA. RESULTS: OCTA could delineate neovessels before treatment in all cases ...

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    9. Effect of Hemodialysis on Anterior Chamber Angle Measured by Anterior Segment Optical Coherence Tomography

      Effect of Hemodialysis on Anterior Chamber Angle Measured by Anterior Segment Optical Coherence Tomography

      Purpose . To investigate the effect of hemodialysis (HD) on the anterior chamber angle by anterior segment optical coherence tomography (ASOCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD). Methods . A prospective observational study was performed on 20 patients who underwent HD for ESKD. Anterior chamber angle images were obtained by 16 mm line scan of ASOCT. The angle opening distance (AOD) and the trabecular-iris space area (TISA) were determined using the ImageJ program. Additional 12 mm horizontal and 9 mm vertical wide-field scans centered on the posterior pole were performed for the measurement of peripapillary retinal nerve ...

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    10. Classification of human stomach cancer using morphological feature analysis from optical coherence tomography images

      Classification of human stomach cancer using morphological feature analysis from optical coherence tomography images

      Optical coherence tomography is radiation-free, and it is considered a tool of optical biopsy. Classification of normal and cancerous tissues is very important for the guidance of surgeons. Here, we develop the morphological feature analysis-based classification (MFAC) method, combining it with machine learning to identify cancerous tissues. We extract five quantitative morphological features from one OCT image through the structured analysis. Five classifiers are involved to make a classification: the support vector machine, the K -nearest neighbor, the random forest, logic regression, and the conventional threshold method. Sensitivity, specificity, and accuracy are used to evaluate these classifiers and are compared ...

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    11. High Resolution Imaging in Microscopy and Ophthalmology New Frontiers in Biomedical Optics (Textbook)

      High Resolution Imaging in Microscopy and Ophthalmology New Frontiers in Biomedical Optics (Textbook)

      Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional tissue imaging. It typically uses light in the near-infrared spectral range which has a penetration depth of several hundred microns in tissue. The backscattered light is measured with an interferometric set-up to reconstruct the depth profile of the sample at the selected location. A scanning OCT beam allows for acquisition of cross-sectional images of the tissue structure. Different technical methods are introduced and compared regarding their properties like sensitivity, imaging speed and penetration depth. Regardless of the technical realization, axial resolution and imaging range of an OCT system are determined ...

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    12. Clinical efficacy of optical coherence tomography to predict the visual outcome after endoscopic endonasal surgery for suprasellar tumors

      Clinical efficacy of optical coherence tomography to predict the visual outcome after endoscopic endonasal surgery for suprasellar tumors

      Objective Prediction of visual outcome following endoscopic endonasal tumor resection still remains a challenge. We investigated the prognostic value of preoperative peripapillary retinal nerve fiber layer (pRNFL) using the optical coherence tomography (OCT) for visual outcome after endoscopic endonasal surgery (EES) for suprasellar tumors. Methods We retrospectively analyzed 122 patients who underwent EES for sellar and suprasellar tumors between January 2016 and January 2018. We retrospectively analyzed the pre- and post-operative relationship between pRNFL thickness and visual outcome, based on the visual acuity (visual acuity score, VAS) and visual field (mean deviation, MD). Results Preoperatively, 216 eyes (mean 94.3 ...

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    13. Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet’s Disease and Healthy Controls

      Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet’s Disease and Healthy Controls

      Purpose : To investigate optical coherence tomography angiography (OCTA) findings in patients with Behçet’s disease (BD). Methods : Ninety-four eyes of 49 patients with BD and 53 eyes of 53 healthy subjects were included. Vascular density (VD), foveal avascular zone (FAZ) area, perifoveal capillary hypoperfusion, perifoveal capillary network disorganization, and FAZ irregularity were analyzed. Results : OCTA revealed retinal VD reduction and higher perifoveal capillary hypoperfusion, perifoveal capillary network disorganization and FAZ irregularity in ocular Behçet’s compared to nonocular Behçet’s ( p = .000). However, compared to normal eyes, there was no difference between any OCTA measurements in nonocular ...

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    14. Diagnostic accuracy of 320-row computed tomography for characterizing coronary atherosclerotic plaques: Comparison with intravascular optical coherence tomography

      Diagnostic accuracy of 320-row computed tomography for characterizing coronary atherosclerotic plaques: Comparison with intravascular optical coherence tomography

      Background/Purpose. This study sought to determine the diagnostic accuracy of 320-row computed tomography (320CT) for characterizing coronary atherosclerotic plaques in comparison with optical coherence tomography (OCT). Methods/Materials. From 32 patients, 42 coronary segments were evaluated and co-registered by both 320CT and OCT. 320CT vulnerable plaque characteristics included low attenuation plaque (LAP) (<30HU), napkin-ring sign (NRS), positive remodeling (PR) and spotty calcification (SC). The presence of macrophage, neovascularization and cholesterol crystals was also determined by OCT. Results Minimal lumen area was 2.78 ± 1.23 mm by OCT and 3.29 ± 1.49 mm by 320CT ( p < 0.001 ...

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    15. Incidence of Irvine Gass Syndrome after Phacoemulsification with Spectral-Domain Optical Coherence Tomography

      Incidence of Irvine Gass Syndrome after Phacoemulsification with Spectral-Domain Optical Coherence Tomography

      Purpose : Incidence of significant and non-significant macular edema found using spectral-domain optical coherence tomography (SD-OCT) following cataract surgery. Methods : Prospective, cohort series conducted at the Croix Rousse University Hospital. Significant macular edema (SME) was defined as the presence of fluid with an increase of 30% or more in central subfield macular thickness compared to baseline on SD-OCT at 6 weeks and non-significant macula edema (NSME) as an increase of less than 30%. Results : Nine hundred and twenty-eight eyes in 638 patients were included in the study. Incidence of Irvine Gass (IG) syndrome was 9%, 2.3% of patients presented SME ...

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    Optical coherence refraction tomography Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging
  6. Recent Quotes

    1. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    2. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    3. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    4. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    5. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    6. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    7. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    8. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    9. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden
    10. We are very excited and honored to partner with the team at Adachi. Adachi’s strong market presence in Otolaryngology, as well as their expertise in navigating Japanese regulatory and reimbursement pathways, will ensure a powerful launch of the TOMi Scope in the Japanese marketplace. We see this partnership as further validation of our technology and its potential to impact healthcare in a meaningful way. We look forward to a long and fruitful relationship with Adachi.
      By Ryan L. Shelton