1. Recent Articles From Around The Web

    1. Optical coherence tomography for dynamic axial correction of an optical end-effector for robot-guided surgical laser ablation

      Optical coherence tomography for dynamic axial correction of an optical end-effector for robot-guided surgical laser ablation

      Robot-guided laser ablation for surgical applications potentially offers many advantages compared to by-hand mechanical tissue cutting. However, given that tissue can be rough and/or uneven, ablation quality can be compromised if the beam waist deviates significantly from the target tissue surface. Therefore, we present a method that uses optical coherence tomography (OCT) for dynamic refocusing of robot-guided surgical laser ablation. A 7-DOF robotic manipulator with an OCT-equipped optical payload was used to simulate robotic guided laser osteotomy. M-mode OCT feedback is used for continuous surface detection to correct for axial deviations along the ablation path due to surface nonuniformity ...

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    2. Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Background To evaluate the efficacy of optical coherence tomography angiography (OCTA) in identifying changes in the choriocapillaris layer after low-fluence verteporfin photodynamic therapy (vPDT) in patients affected by chronic central serous chorioretinopathy (CSCR). Methods Low-fluence vPDT was performed on 28 eyes of 27 patients with CSCR. All patients underwent the following tests at baseline and 6 months after treatment: best corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT and OCTA. Results Subretinal fluid was completely absorbed in 18 of the 28 affected eyes (64.3%) after low-fluence vPDT (“responders”), and incompletely absorbed in 10 eyes ...

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    3. Automatic Classification of Retinal Optical Coherence Tomography Images With Layer Guided Convolutional Neural Network

      Automatic Classification of Retinal Optical Coherence Tomography Images With Layer Guided Convolutional Neural Network

      Optical coherence tomography (OCT) enables instant and direct imaging of morphological retinal tissue and has become an essential imaging modality for ophthalmology diagnosis. As one of the important morphological retinal characteristics, the structural information of retinal layers provides meaningful diagnostic information and is closely related to several retinal diseases. In this letter, we propose a novel layer guided convolutional neural network (LGCNN) to identify normal retina and three common types of macular pathologies, namely, diabetic macular edema, drusen, and choroidal neovascularization. Specifically, an efficient segmentation network is first employed to generate the retinal layer segmentation maps, which can delineate two ...

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    4. Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity

      Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity

      ims: A novel method for computation of fractional flow reserve (FFR) from optical coherence tomography (OCT) was developed recently. This study aimed to evaluate the diagnostic accuracy of a new OCT-based FFR (OFR) computational approach, using wire-based FFR as the reference standard. Methods and results: Patients who underwent both OCT and FFR prior to intervention were analysed. The lumen of the interrogated vessel and the ostia of the side branches were automatically delineated and used to compute OFR. Bifurcation fractal laws were applied to correct the change in reference lumen size due to the step-down phenomenon. OFR was compared with ...

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    5. Segmentation of Retinal Cysts From Optical Coherence Tomography Volumes Via Selective Enhancement

      Segmentation of Retinal Cysts From Optical Coherence Tomography Volumes Via Selective Enhancement

      Automated and accurate segmentation of cystoid structures in optical coherence tomography (OCT) is of interest in the early detection of retinal diseases. It is, however, a challenging task. We propose a novel method for localizing cysts in 3-D OCT volumes. The proposed work is biologically inspired and based on selective enhancement of the cysts, by inducing motion to a given OCT slice. A convolutional neural network is designed to learn a mapping function that combines the result of multiple such motions to produce a probability map for cyst locations in a given slice. The final segmentation of cysts is obtained ...

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    6. OCT Signs Associated With Fellow Eye AMD Progression

      OCT Signs Associated With Fellow Eye AMD Progression

      Researchers confirmed that four previously reported optical coherence tomography (OCT) risk factors were associated with progression to late age-related macular degeneration (AMD) in the fellow eyes of participants newly diagnosed with macular neovascularization. This multicenter, prospective, randomized, double-masked, active treatment-controlled phase 3 clinical trial evaluated 501 eyes of 501 patients with macular neovascularization secondary to neovascular AMD and early or intermediate AMD in the fellow eye. The team reviewed OCT scans and assessed baseline features, including intraretinal hypereflective foci (IHRF), hyporeflective foci (hRF) within drusenoid lesions (DLs), subretinal drusenoid deposits (SDDs) and drusen volume (DV) ≥ 0.03 mm 3 . Masked ...

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    7. Comparison of foveal avascular zone between optical coherence tomography angiography and fluorescein angiography in patients with retinal vein occlusion

      Comparison of foveal avascular zone between optical coherence tomography angiography and fluorescein angiography in patients with retinal vein occlusion

      Objective To compare area of foveal avascular zone (FAZ) in different retinal vascular layers in optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) in patients with retinal vein occlusion (RVO). Design and methods Prospective cross-sectional comparative study in 47 eyes of 47 patients. FA was recorded with the Zeiss FF450plusIR camera and OCTA was obtained with the Zeiss Cirrus 5000 equipped with the AngioPlex module. Area of FAZ was graded by two independent investigators and calculated with Adobe Photoshop. Analysis for the total study population as well as subgroup analysis for branch retinal vein occlusion (BRVO), central retinal vein ...

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    8. Measuring mechanical wave speed, dispersion, and viscoelastic modulus of the cornea using optical coherence elastography

      Measuring mechanical wave speed, dispersion, and viscoelastic modulus of the cornea using optical coherence elastography

      Acoustic wave velocity measurement based on optical coherence tomography (OCT) is a promising approach to assess the mechanical properties of biological tissues and soft materials. While studies to date have demonstrated proof of concept of different ways to excite and detect mechanical waves, the quantitative performance of this modality as mechanical measurement has been underdeveloped. Here, we investigate the frequency dependent measurement of the wave propagation in viscoelastic tissues, using a piezoelectric point-contact probe driven with various waveforms. We found that a frequency range of 2–10 kHz is a good window for corneal elastography, in which the lowest-order flexural ...

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    9. Intraoperative optical coherence tomographic findings may predict postoperative visual outcome in eyes with idiopathic macular hole

      Intraoperative optical coherence tomographic findings may predict postoperative visual outcome in eyes with idiopathic macular hole

      Purpose To determine the significance of the correlation between the intraoperative optical coherence tomographic (OCT) findings and the postoperative retinal morphology and physiology in eyes with an idiopathic macular hole (MH). Design Retrospective interventional case control study. Subjects Pars plana vitrectomy with internal limiting membrane (ILM) peeling and air tamponade was performed on 33 eyes with idiopathic MHs. All of the eyes were followed for at least 6 months. Methods The intraoperative OCT (Rescan, Carl Zeiss Meditec) images were used to detect the presence of residual fragments at the edge of the MH, and the eyes were divided into those ...

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    10. Assessment of posterior capsular integrity on optical coherence tomography

      Assessment of posterior capsular integrity on optical coherence tomography

      The integrity of posterior capsule is of paramount importance to cataract surgeon. Careful preoperative assessment is routinely performed to avoid undesirable intraoperative complications. Routine slit-lamp-based assessment provides a detailed understanding of the posterior capsule, provided that lens matter is optically clear to an acceptable extent. However, the presence of opacity along the posterior capsule with a hidden defect such as posterior polar cataract may pose a challenge to decipher the intactness of the capsule. 1 Under such circumstances, noninvasive imaging modalities, such as anterior segment optical coherence tomography (OCT), is at surgeons rescue during the preoperative period. Therefore, here we ...

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    11. An averaged intensity difference detection algorithm for identification of human gingival sulcus in optical coherence tomography images

      An averaged intensity difference detection algorithm for identification of human gingival sulcus in optical coherence tomography images

      In the past decade, there has been an increase in the development of sensitive, highresolution, non-invasive diagnostic methods for periodontic diseases. Optical coherence tomography (OCT) has attracted considerable attention in clinical settings. In this study, a reliable, robust algorithm for the detection of gingival sulcus in 2D OCT cross-sectional images is proposed. Previously, the measurement of gingival sulcus in OCT images has been performed by manual identification using two-dimensional (2D) cross-sectional images. The automated detection of gingival sulcus continuity in 2D OCT images may help medical practitioners to assess important features of gingival tissues. The Sobel and canny operators have ...

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    12. Localized compliance measurement of the airway wall using anatomic optical coherence elastography

      Localized compliance measurement of the airway wall using anatomic optical coherence elastography

      We describe an elastographic method to circumferentially-resolve airway wall compliance using endoscopic, anatomic optical coherence tomography (aOCT) combined with an intraluminal pressure catheter. The method was first demonstrated on notched silicone phantoms of known elastic modulus under respiratory ventilation, where localized compliance measurements were validated against those predicted by finite element modeling. Then, ex vivo porcine tracheas were scanned, and the pattern of compliance was found to be consistent with histological identification of the locations of (stiff) cartilage and (soft) muscle. This quantitative method may aid in diagnosis and monitoring of collapsible airway wall tissues in obstructive respiratory disorders.

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    13. Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

      Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

      Background The association between mean platelet volume (MPV) and coronary plaque vulnerability in patients with non-ST-elevation ACS (NSTE-ACS) has not been investigated. We performed a retrospective study to evaluate the association between MPV and plaque vulnerability using optical coherence tomography (OCT). Methods Consecutive NSTE-ACS patients who underwent pre-intervention OCT examination in our center were included in this study. Features of coronary plaques in the culprit arteries were classified as rupture, nonrupture with thin-cap fibroatheroma (TCFA), and nonrupture and non-TCFA. ROC analyses were used to determine the predictive efficacy of MPV for plaque rupture, and multivariate logistic regression analysis was performed ...

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    14. Optical coherence tomography angiography of perilimbal vasculature: validation of a standardised imaging algorithm

      Optical coherence tomography angiography of perilimbal vasculature: validation of a standardised imaging algorithm

      Purpose To test the reliability and accuracy of a standardised non-invasive imaging algorithm using optical coherence tomography angiography (OCTA) in detecting and quantifying pharmacologically induced changes in the perilimbal vasculature. Methods In this prospective observational imaging study, 370 angiograms of 15 normal eyes and 10 eyes with nasal pterygiums were obtained using a commercially available OCTA system with split-spectrum amplitude-decorrelation angiography technology. Postprocessing of the images to quantify the area occupied by the blood vessels was performed using the Fiji software. The main outcome measures were reliability (intraobserver and interobserver agreement) and accuracy of the standardised algorithm in detecting and ...

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  5. Picture Gallery

    Convective Nozaki-Bekki holes in a long cavity OCT laser Research Associate in Biophotonics Openings at the Univesity of Sheffield (2 openings) Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo Upper limit for angular compounding speckle reduction GGold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study Expert consensus published on use of imaging to guide heart attack treatment Research Scientist for Optical Diagnostic at Carestream Dental Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study PhD Studentship Opening at The University of Liverpool
  6. Recent Quotes

    1. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    2. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    3. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    4. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    5. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    6. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden
    7. We are very excited and honored to partner with the team at Adachi. Adachi’s strong market presence in Otolaryngology, as well as their expertise in navigating Japanese regulatory and reimbursement pathways, will ensure a powerful launch of the TOMi Scope in the Japanese marketplace. We see this partnership as further validation of our technology and its potential to impact healthcare in a meaningful way. We look forward to a long and fruitful relationship with Adachi.
      By Ryan L. Shelton
    8. You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube...Many lesions in the mouth have been re-mineralized and...no longer need inter­vention,” said Fried. “Dentists have trouble telling the difference between active and arrested lesions; this new technology has the potential of differentiating them.
      By Daniel S. Fried
    9. OCT [already] has changed the practice of ophthalmol­ogy...It’s been very successful for retinal imaging...and it’s also very promising for dentistry...If the dentist doesn’t know if [a lesion] is active or arrested,” said Fried, “with OCT, you can actually see the lesion struc­ture, how deep it is and if it has a definitive surface zone suggesting that remineralization has occurred.
      By Daniel S. Fried
    10. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson