1. Recent Articles From Around The Web

    1. Free-Floating Pigmented Vitreous Cyst: Optical Coherence Tomography Findings

      Free-Floating Pigmented Vitreous Cyst: Optical Coherence Tomography Findings

      A 54-year-old woman presented with a chronic floater in the right eye. Dilated fundus examination revealed a pigmented free-floating vitreous cyst (Fig 1 A , Optos, Marlborough, MA). Saccades caused quick and fluid movements of the mobile sphere. Spectral-domain optical coherence tomography (SD OCT) (Fig 1 B , Spectralis; Heidelberg, Heidelberg, Germany) demonstrated a round, hyperreflective shell with hyporeflective contents. The lesion is anterior to the upper limit of the OCT and appears as a reflected image with shadowing of the underlying retina.

      Read Full Article
    2. Micrometer-resolution in-fiber OCT probe with tunable working distance

      Micrometer-resolution in-fiber OCT probe with tunable working distance

      Optical coherence tomography (OCT) is an attractive modality in biomedical imaging systems due to its non-invasive imaging character. Since the image quality of OCT may be limited by the decrease of transverse resolution away from the focus spot, working distance tunable probe can be a strategy to overcome such limitation and maintain high transverse resolution at different imaging depths. In this paper, a miniature, working distance-tunable in-fiber OCT probe is demonstrated. The influences of the graded index fiber (GIF) length as well as the air cavity length on the working distance and the transverse resolution are simulated and discussed. Experimental ...

      Read Full Article
    3. Angular compounding by full-channel B-scan modulation encoding for optical coherence tomography speckle reduction

      Angular compounding by full-channel B-scan modulation encoding for optical coherence tomography speckle reduction

      We describe an angular compounding method by full-channel B-scan modulation encoding for speckle reduction in optical coherence tomography. The complex-valued spectral interferogram (SI) is reconstructed by removing one of the conjugate terms in the depth space. Fourier transform of the complex SI along the lateral direction enables a full-channel (with both negative and positive Fourier space) for B-scan modulation in the spatial frequency ( ν ν ) domain. A full-size probe beam, determined by the scanning mirror size, is centered on the mirror pivot, which allows the negative and positive half-channels working in parallel. Compared with the existing method, where only a half-channel (negative ...

      Read Full Article
    4. Calibration of optical coherence tomography angiography with a microfluidic chip

      Calibration of optical coherence tomography angiography with a microfluidic chip

      A microfluidic chip with microchannels ranging from 8 to 96    μ m 96  μm was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width. SSADA could differentiate nonflowing blood inside the microfluidic channels from static paper. The SSADA decorrelation value was approximately linear with blood flow velocity up to a threshold V sat Vsat of 5.83 ± 1.33    mm / s 5.83 ...

      Read Full Article
    5. Anterior segment optical coherence tomography of silicone oil keratopathy

      Anterior segment optical coherence tomography of silicone oil keratopathy

      A 77-year-old woman underwent pars plana vitrectomy for recurrent retinal detachment with silicone oil injection 10 years before presentation. Also the patient was placed on antiglaucoma medications. The patient had a history of recurrent corneal ulcerations in both eyes due to severe dry eyes. Examination revealed no light perception with a disfiguring central opaque corneal bulge in the left eye (figure 1). Anterior segment optical coherence tomography (OCT) revealed a marked thickening …

      Read Full Article
    6. Time-Series Interactions of Gene Expression, Vascular Growth and Hemodynamics during Early Embryonic Arterial Development

      Time-Series Interactions of Gene Expression, Vascular Growth and Hemodynamics during Early Embryonic Arterial Development

      The role of hemodynamic forces within the embryo as biomechanical regulators for cardiovascular morphogenesis, growth, and remodeling is well supported through the experimental studies. Furthermore, clinical experience suggests that perturbed flow disrupts the normal vascular growth process as one etiology for congenital heart diseases (CHD) and for fetal adaptation to CHD. However, the relationships between hemodynamics, gene expression and embryonic vascular growth are poorly defined due to the lack of concurrent, sequential in vivo data. In this study, a long-term, time-lapse optical coherence tomography (OCT) imaging campaign was conducted to acquire simultaneous blood velocity, pulsatile micro-pressure and morphometric data for ...

      Read Full Article
      Mentions: Thorlabs
    7. Retinal and choroidal thicknesses measured with swept-source optical coherence tomography after surgery for idiopathic macular hole

      Retinal and choroidal thicknesses measured with swept-source optical coherence tomography after surgery for idiopathic macular hole

      To evaluate the changes in retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), retinal thickness (RT), and subfoveal choroidal thickness (SFCT) in eyes that received pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH) and to compare these data with data from fellow eyes and healthy controls. This cross-sectional study included 49 subjects. Eighteen eyes that underwent surgery for IMH, 18 fellow eyes, and 31 eyes of the healthy controls were designated as group 1, group 2, and group 3, respectively. The RNFLT, GCLT, RT, and SFCT were measured by using ...

      Read Full Article
    8. Comparison of the marginal adaptation of direct and indirect composite inlay restorations with optical coherence tomography

      Comparison of the marginal adaptation of direct and indirect composite inlay restorations with optical coherence tomography

      Objective The purpose of the study was to use the photonic imaging modality of optical coherence tomography (OCT) to compare the marginal adaptation of composite inlays fabricated by direct and indirect techniques. Material and Methods Class II cavities were prepared on 34 extracted human molar teeth. The cavities were randomly divided into two groups according to the inlay fabrication technique. The first group was directly restored on cavities with a composite (Esthet X HD, Dentsply, Germany) after isolating. The second group was indirectly restored with the same composite material. Marginal adaptations were scanned before cementation with an invisible infrared light ...

      Read Full Article
      Mentions: Thorlabs
    9. A Case of Wyburn-Mason Syndrome with Facial Nevus Flammeus and the Associated Optical Coherence Tomography Findings

      A Case of Wyburn-Mason Syndrome with Facial Nevus Flammeus and the Associated Optical Coherence Tomography Findings

      Purpose To describe a case of Wyburn-Mason Syndrome, which is a rare phakomatosis, and its associated optical coherence tomography findings. Case summary A 5-year-old boy was referred to our clinic for decreased vision in his right eye. He had nevus flammeus on his right forehead, upper eyelid, and cheek. His best corrected visual acuity was hand motion in the right eye, in which a relative afferent pupillary defect was noted. Fundus examination of the right eye showed marked dilation and tortuosity of retinal vessels, which could not be discriminated between arteries and veins on the posterior pole. Optical coherence tomography ...

      Read Full Article
    10. Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Purpose : Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. Methods : In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mice. Data was compared with FA and confocal microscopy of flat-mount histology stained with isolectin IB4. For quantitative analysis the National Cancer Institute's AngioTool software was used. Vessel density, the number of vessel junctions, and endpoints were measured and compared between the imaging ...

      Read Full Article
    11. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      Purpose: To examine the retinal and choroidal foveal and parafoveal vasculature in patients with bilateral geographic atrophy (GA) secondary to age-related macular degeneration using optical coherence tomography angiography (OCTA). Methods: Fourteen eyes from 7 patients with and without fovea-sparing bilateral GA at St. Erik Eye Hospital. All patients were examined by optical coherence tomography angiography, en face OCT and fundus autofluorescence (FAF). Segmented optical coherence tomography angiography flow scans were obtained from the superficial retinal vascular layer (SL) and the choriocapillaris (CC) and correlated with areas of retinal pigment epithelial (RPE) loss on fundus autofluorescence. The foveal avascular zone (FAZ ...

      Read Full Article
    12. CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To visualize choroidal blood flow in larger vessels in highly myopic eyes using a phenomenon of the projection artifact to in the sclera using optical coherence tomography angiography. Methods: The retrospective study included 92 eyes (54 patients) with greater than 8 diopters of myopia. All eyes were examined using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The blood flow in choroidal vessels was evaluated by attempting to directly segment the choroid and also by placing the segmentation layer behind the choroid, within the sclera. Subfoveal choroidal thickness was also measured at the same time. The ...

      Read Full Article
    13. CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      Purpose: To report subclinical retinal hemangioblastoma detected by enhanced depth imaging optical coherence tomography and fluorescein angiography in at-risk twins. Methods: Case report. Results: A set of twins, age 7 years, (Twin A and Twin B) with known family history of von Hippel-Lindau disease (gene test positive) and no systemic manifestations were evaluated. Visual acuity was 20/20 in both eyes of both twins. Anterior segment examination and intraocular pressures were unremarkable in both eyes. Twin A showed no clinically visible tumor in the right eye, and a clinically evident 4-mm hemangioblastoma in the superior retina of the left eye ...

      Read Full Article
    14. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (1 articles) University of Zurich
    2. (1 articles) Center for Ophthalmic Optics and Lasers
    3. (1 articles) Harvard University
    4. (1 articles) UC Irvine
    5. (1 articles) University of Illinois at Urbana-Champaign
    6. (1 articles) Asan Medical Center
    7. (1 articles) University of Florida
    8. (1 articles) University of Ulsan
    9. (1 articles) Oregon Health & Science University
    10. (1 articles) Zhejiang University
  3. People in the News

    1. (1 articles) Zhihua Ding
    2. (1 articles) P. Scott Carney
    3. (1 articles) Gangjun Liu
    4. (1 articles) David Huang
    5. (1 articles) Brian J. F. Wong
    6. (1 articles) Huikai K. Xie
    7. (1 articles) Zhongping Chen
    8. (1 articles) Yali Jia
    9. (1 articles) Peng Li
    10. (1 articles) Stephen A. Boppart
  4. OCT Companies in the News

    1. (2 articles) Thorlabs
    2. (1 articles) WiO Technology Limited
    3. (1 articles) Optos
  5. OCT Products in the News

    1. (1 articles) Heidelberg Spectralis
  6. Picture Gallery

    Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range Hybrid averaging offers high-flow contrast by cost apportionment among imaging time, axial, and lateral resolution in optical coherence tomography angiography Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography Optical Assessment of Soft Contact Lens Edge-Thickness Optical Coherence Tomography for Lesion Assessment Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging Postdoctoral Fellows Openings at Northwestern University Postdoctoral Position in OCT at the University of Houston Optics Augments Reality and Brings 3D Medicine into Focus
  7. Recent Quotes

    1. We are excited to bring to market groundbreaking technologies that provide valuable new, detailed information about the microvasculature of the eye, in a manner that reduces the burden for both the patient and the clinic staff...DualTrac Motion Correction allows for improved imaging and quicker data collection to further the clinical utility of OCTA technology by accommodating natural eye movement.
      By Jay Wei
    2. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      By David Huang
    3. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      By Wolfgang Drexler
    4. This gives us a very controlled way of looking at ovarian cancer.
      By Jennifer K. Barton
    5. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      By Jennifer K. Barton
    6. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    7. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
      By Philip J. Rosenfeld
    8. Our goal with MicroAngio is to provide a flexible tool that can be used in an optimal fashion for a wide range of applications...MicroAngio comes with customized probes and fixtures for small animal retinal, dorsal window chamber and brain imaging. We also provide a suite of algorithms for data analysis essential for angiographic imaging.”
      By Nishant Mohan
    9. In the majority of cases it is clinically and dermoscopically possible to differentiate between AK and BCC, but there are difficult situations, especially in early cases or during topical therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear...This data published shows that VivoSight OCT is not only able to differentiate between the two diseases by means of epidermal thickness and signal intensity measurements but also able to be used as a non-invasive technique to determine and monitor the treatment. This technology significantly improves the diagnostic methods currently used resulting in better outcomes for patients.
      By Julia Welzel
    10. We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness...Since we first introduced this technology to markets outside the U.S. fourteen months ago, the technology is in daily clinical use at over 525 clinical sites where it provides a more patient-friendly approach to diseases of the retina that lead to progressive blindness.
      By Jay Wei