1. Recent Articles From Around The Web

    1. Paravascular abnormalities observed by spectral domain optical coherence tomography are risk factors for retinoschisis in eyes with high myopia

      Paravascular abnormalities observed by spectral domain optical coherence tomography are risk factors for retinoschisis in eyes with high myopia

      Purpose To investigate the retinal features and distribution of paravascular abnormalities (PVAs) and their relationship with retinoschisis in eyes with high myopia. Methods One hundred and fifty-two eyes of 88 patients with high myopia [refractive error greater than −6 dioptres (D) or axial length (AL) ≥26.5 mm] who had undergone comprehensive ophthalmic examinations were evaluated in this cross-sectional study. Multiple optical coherence tomography (OCT) scans were performed to study the microstructural alterations adjacent to the retinal vascular arcades and the entire macular area. The presence and distribution patterns of various PVAs, retinoschisis and the association between these parameters were ...

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    2. OPTICAL COHERENCE TOMOGRAPHY 2: DIAGNOSTIC TOOL TO STUDY PERIPHERAL VITREORETINAL PATHOLOGIES

      OPTICAL COHERENCE TOMOGRAPHY 2: DIAGNOSTIC TOOL TO STUDY PERIPHERAL VITREORETINAL PATHOLOGIES

      Purpose: To investigate the utility of new wide-field optical coherence tomography (OCT) device in the evaluation of mid and far retinal periphery and to show its feasibility and advantages in clinical practice. Methods: Consecutive patients underwent a complete ophthalmologic examination including standard OCT and new prototype OCT2 derived from Heidelberg Spectralis. Results: Thirty-one eyes of 31 patients were studied with a total of 44 lesions, including 18 retinal detachments, 15 retinal holes and tears, 9 retinoschisis, and 2 retinal tufts. Fourteen (32%) lesions were found in mid and 30 (68%) in far periphery with 9 (20%) lesions in the superior ...

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    3. Interocular Symmetry of Vascular Density and Association with Central Macular Thickness of Healthy Adults by Optical Coherence Tomography Angiography

      Interocular Symmetry of Vascular Density and Association with Central Macular Thickness of Healthy Adults by Optical Coherence Tomography Angiography

      In order to analyze the interocular correlation of vascular density, foveal avascular zone (FAZ) size, central macular thickness (CMT), and to investigate the relationship between vascular density and CMT in normal eyes, retinal vascular density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) networks, FAZ size, and CMT were visualized by optical coherence tomography (OCT) angiography. A total of 174 eyes of 87 normal Chinese subjects were enrolled in the study. The results showed that FAZ and CMT measurements are not statistically significant between right and left eyes, but right eyes had higher vascular density in ...

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    4. In vitro determination of Mexican Mestizo hair shaft diameter using optical coherence tomography

      In vitro determination of Mexican Mestizo hair shaft diameter using optical coherence tomography

      Background Mexican mestizo population has a pluriethnic mixture of Amerindian, European and African ancestry, predominant in most Latin American countries. Until now, there are no reports about hair characteristics in this population, necessary to define normal values, for hair diseases evaluation and comparison among other ethnic groups. Methods The VivoSight ® swept-source multibeam optical coherence tomography system was used to evaluate hair diameter and shape in 30 females. Three hair samples from each volunteer were measured transversely along three distances, generating nine cross-sectional images, two measurements per image and 18 measurements per patient for a total of 540 diameter measurements. Results ...

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    5. Intraoperative optical coherence tomography to evaluate the effect of the eyelid speculum on corneal pachymetry during accelerated corneal cross-linking (9 mW/cm2)

      Intraoperative optical coherence tomography to evaluate the effect of the eyelid speculum on corneal pachymetry during accelerated corneal cross-linking (9 mW/cm2)

      Purpose To investigate intraoperative anterior segment optical coherence tomography (AS-OCT) to compare pachymetry changes between two methods (group 1: speculum-on, group 2: speculum-off during riboflavin instillation stage) during corneal cross-linking /CXL) (9 mW/cm 2 for 10 min) in keratoconic patients. Methods In this interventional case series, 11 eyes (11 patients) in group 1 and 14 eyes (14 patients) in group 2 were enrolled. Pachymetry measurements by spectral domain OCT was performed at baseline, after epithelial removal, after 30 min of imbibition with riboflavin, and after UV irradiation. Repeated measures analysis of variance was used to compare the trend of ...

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    6. Prediction of scar size in rats six months after burns based on early post injury polarization-sensitive optical frequency domain imaging

      Prediction of scar size in rats six months after burns based on early post injury polarization-sensitive optical frequency domain imaging

      Hypertrophic scars remain a major clinical problem in the rehabilitation of burn survivors and lead to physical, aesthetic, functional, psychological, and social stresses. Prediction of healing outcome and scar formation is critical for deciding on the best treatment plan. Both subjective and objective scales have been devised to assess scar severity. Whereas scales of the first type preclude cross-comparison between observers, those of the second type are based on imaging modalities that either lack the ability to image individual layers of the scar or only provide very limited fields of view. To overcome these deficiencies, this work aimed at developing ...

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    7. Optical coherence tomography in diagnosis and monitoring multiple sclerosis

      Optical coherence tomography in diagnosis and monitoring multiple sclerosis

      This paper presents application of optical coherence tomography (OCT) for diagnosis and monitoring of multiple sclerosis (MS). The peripapillary retinal nerve fibre layer thinning and the reduced total macular volume analysis are shown. With the course of the MS, the severity of these abnormalities increases which reflects the progressive degeneration of retinal ganglion cells and nerve fibres. The OCT parameters are sensitive, non-invasive indicators useful in assessing the progression of inflammation and neurodegeneration in MS.

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    8. Very Late Scaffold Thrombosis: Insights from Optical Coherence Tomography and Histopathology

      Very Late Scaffold Thrombosis: Insights from Optical Coherence Tomography and Histopathology

      Aims: to investigate and understand the mechanisms of very late scaffold thrombosis 13 months following implantation in the setting of bare metal in-stent restenosis. Methods and results: we collected consecutive angiography, optical coherence tomography and full autopsy evaluation in a 79-year old patients presenting with cardiogenic shock and undergoing rescue PCI after suffering very late scaffold thrombosis. Combined assessment of angiography, optical coherence tomography and histopathology revealed heterogenous vascular healing 13 months following implantation of a bioresorbable vascular scaffold with presence of scaffold struts fully integrated into neointimal tissue while others remained uncovered and malapposed. Furthermore, plaque rupture within the ...

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    9. Six-month postoperative outcomes of intraoperative OCT-guided surgical cystotomy for refractory cystoid macular edema in diabetic eyes

      Six-month postoperative outcomes of intraoperative OCT-guided surgical cystotomy for refractory cystoid macular edema in diabetic eyes

      ... Purpose: This study evaluated the outcomes of surgical cystotomy for recurrent diabetic cystoid macular edema (CME). Patients and methods: We analyzed 20 eyes with a clinical diagnosis of diabetic retinopathy and refractory CME. Release of vitreoretinal adhesion, epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling and cystotomy guided by intraoperative optical coherence tomography (iOCT) were performed in every patient. Pars plana vitrectomy was also performed in 17 patients, 11 of whom also underwent lensectomy and intraocular lens implantation. Central retinal thickness (CRT), central minimum macular thickness (CMMT), macular volume (MV) and best-corrected visual acuity (BCVA) were compared preoperatively and ...

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    10. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based the functional contrasts provided by the CP-OCT system. The feasibility of using A-line profiles from the two orthogonal polarization ...

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    11. Zero-contrast percutaneous coronary intervention guided by dextran-based optical coherence tomography

      Zero-contrast percutaneous coronary intervention guided by dextran-based optical coherence tomography

      Subjects with advanced chronic kidney disease (CKD) and coronary artery disease are often denied percutaneous coronary intervention (PCI) due to the aversion to the risk of contrast-induced nephropathy. We present the case of a 76-year-old man with stage 4 CKD requiring coronary revascularization. Zero-contrast PCI was successfully performed using dextran-based optical coherence tomography (OCT) guidance. Our report suggests the feasibility of dextran-based OCT-guided zero-contrast PCI in patients with advanced CKD. Further studies should evaluate the safety and efficacy of this novel approach.

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    12. Neuroimaging diagnostic and monitoring approaches in ophthalmology

      Neuroimaging diagnostic and monitoring approaches in ophthalmology

      Purpose of review We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA). Recent findings Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Swept-source OCT and enhanced-depth imaging OCT are refining the fine-grained analysis of the optic nerve head in the diagnosis of papilledema and optic nerve drusen. OCT-angiography is opening up new avenues to the study of the vasculature of ...

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    13. Clinical Outcomes Following Intravascular Imaging-Guided Versus Coronary Angiography–Guided Percutaneous Coronary Intervention With Stent Implantation

      Clinical Outcomes Following Intravascular Imaging-Guided Versus Coronary Angiography–Guided Percutaneous Coronary Intervention With Stent Implantation

      Objectives The authors sought to explore the comparative clinical efficacy of different imaging modalities for guiding percutaneous coronary interventions (PCI). Background Coronary angiography (CA) is the standard imaging modality for intraprocedural guidance of PCI. Intracoronary imaging techniques, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), can overcome some limitations of CA. Methods Comprehensive hierarchical Bayesian network meta-analysis of randomized clinical trials and adjusted observational studies comparing clinical outcomes of PCI with stent implantation guided by CA, IVUS, or OCT. Results A total of 31 studies encompassing 17,882 patients were included. Compared with CA guidance, the risks of all-cause ...

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    14. Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

      Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

      Background Angiotensin receptor blockers (ARBs) are known for its anti-inflammatory and anti-proliferative effects. The aim of the study was to evaluate long-term effects of ARBs on morphologic characteristics of stent restenosis in patients with coronary artery disease requiring stent implantation by optical coherence tomography (OCT). Methods Patients with coronary artery disease having history of drug-eluting stent implantation ( n  = 407) were analyzed on the basis of ARB therapy as the ARB group ( n  = 162) and the non-ARB group ( n  = 245). Neointimal characterizations were performed at lesions with diameter stenosis >30% with OCT in each group. Major adverse cardiovascular events (MACEs), lumen ...

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    15. Medium-term Anatomical Results of Laser Peripheral Iridoplasty: An Anterior Segment Optical Coherence Tomography Study

      Medium-term Anatomical Results of Laser Peripheral Iridoplasty: An Anterior Segment Optical Coherence Tomography Study

      Aim To evaluate by anterior segment optical coherence tomography (AS-OCT) the medium-term (mean duration 3.2 years) anatomical changes in the anterior chamber angle (ACA) after laser peripheral iridoplasty. Materials and methods This is a longitudinal, retrospective case series of 31 eyes of 31 patients with primary angle-closure suspicion, primary angle closure (PAC), or primary angle-closure glaucoma (PACG) who underwent laser peripheral iridoplasty. All patients had persistent iridotrabecular contact (ITC) despite the presence of a patent peripheral iridotomy (PI). An AS-OCT was performed in dark conditions before and after laser iridoplasty. Quadrants of ITC, intraocular pressure (IOP), and the AS-OCT ...

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    Heidelberg Engineering Announces the Passing of its Co-Founder Dr. Gerhard Zinser Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy The Future of Imaging in Detecting Glaucoma Progression Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography Multi-shaping technique reduces sidelobe magnitude in optical coherence tomography Postdoctoral Research Fellowships  in Optical Coherence Tomography at the Wellman Center for Photomedicine Massachusetts General Hospital Boston, MA USA OCT Amplitude and Speckle Statistics of Discrete Random Media Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser OCT power package reveals subsurface details during ophthalmic surgery Q-switch-pumped supercontinuum for ultra-high resolution optical coherence tomography OCT for the People Paravascular abnormalities observed by spectral domain optical coherence tomography are risk factors for retinoschisis in eyes with high myopia
  6. Recent Quotes

    1. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    2. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    3. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei
    4. Combining en-face OCT with movement detection within blood vessels, we get OCT-A, and with it a new imaging era.
      By Eric H. Souied
    5. Obtaining the Category III CPT code for OCT of the skin is an important step towards our goal of obtaining reimbursement and coverage, and we welcome the new codes that can be used by clinicians to record their clinical use of VivoSight OCT in their practice.
      By Jon Holmes
    6. We showed that you can take effectively any OCT system out there and, with minimal changes, boost its resolution to the point where it can detect anatomical features smaller than the size of a typical cell.
      By Adam de la Zerda
    7. This honor highlights the commitment Avinger has to bring the most advanced technology to market for physicians dedicated to treating PAD and their patients who are affected by this disease...Pantheris radically changes the treatment of vascular disease and the Edison Award represents a win for our entire Lumivascular portfolio.
      By John B. Simpson
    8. While we have been actively advancing our lesion assessment technology for the last two years, we are very pleased to see that the significant Series B investment will give MedLumics the means to complete our best-in-class product, conduct a series of international clinical trials to prove its safety and efficacy, and market it to specialist centers. As the company advances and grows into new areas, we will now expand and develop the team internationally.
      By Eduardo Margallo Balbás
    9. It's the most rapidly adopted ophthalmic technology in history.
      By Joel S. Schuman
    10. Our OCT Angiography congresses is a major force in promoting the transition from FA to OCTA by educating the ophthalmologists .
      By Bruno Lumbroso