1. Recent Articles From Around The Web

    1. Diagnostic accuracy of OCTA and OCT for myopic choroidal neovascularisation: a systematic review and meta-analysis

      Diagnostic accuracy of OCTA and OCT for myopic choroidal neovascularisation: a systematic review and meta-analysis

      Background/objectives: The purpose of this project was to systematically review and meta-analyse studies assessing the diagnostic accuracy of optical coherence tomography angiography (OCTA) and optical coherence tomography (OCT) for myopic choroidal neovascularisation (mCNV). Fluorescein angiography (FA) was accepted as the reference standard. Methods: PUBMED and EMBASE were searched from inception to March 2021 for studies evaluating the test accuracy of OCTA and/or OCT for diagnosing mCNV. The Preferred Reporting Items for Systematic Reviews and Meta-analyses of Diagnostic Test Accuracy Studies guideline was followed, and the Grading of Recommendations, Assessment, Development and Evaluation approach was used to frame clinical ...

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    2. Assessment of optic disk by disk damage likelihood scale staging using slit-lamp biomicroscopy and optical coherence tomography in diagnosing primary open-angle glaucoma

      Assessment of optic disk by disk damage likelihood scale staging using slit-lamp biomicroscopy and optical coherence tomography in diagnosing primary open-angle glaucoma

      Purpose: The current study was aimed at assessment of optic disk by disk damage likelihood scale (DDLS) staging using slit-lamp biomicroscopy and optical coherence tomography (OCT) in diagnosing primary open-angle glaucoma (POAG) patients. Methods: This was a cross-sectional observational study of 106 POAG patients, which was conducted from April 2017 to April 2018. All patients underwent slit-lamp fundoscopy with a +78 D lens and high-definition (HD)-OCT, and the vertical cup disk ratios (VCDRs) were recorded. Disk size and neuroretinal rim assessment were done, and the disk was then staged using the recent version, which stages the optic nerve head ...

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    3. Central macular thickness and subfoveal choroidal thickness changes on spectral domain optical coherence tomography after cataract surgery in pediatric population

      Central macular thickness and subfoveal choroidal thickness changes on spectral domain optical coherence tomography after cataract surgery in pediatric population

      Purpose: To evaluate the central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) changes on spectral domain optical coherence tomography (SD-OCT) after cataract surgery with intraocular lens (IOL) implantation in a pediatric population. Methods: This was a longitudinal, prospective, interventional study which included 90 pediatric patients who underwent cataract extraction with IOL implantation. Serial SD-OCT scans were done at postoperative day 1, 1-month, and 3-month follow-up. CMT and SFCT were measured at each visit. Results: A statistically significant increase in CMT was noted at 1 month (from 199.3 μm to 210.04 μm) post surgery, which declined over a ...

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    4. Anterior segment optical coherence tomography characteristics and management of a unique spectrum of foreign bodies in the cornea and anterior chamber

      Anterior segment optical coherence tomography characteristics and management of a unique spectrum of foreign bodies in the cornea and anterior chamber

      Purpose: To report anterior-segment optical coherence tomography (ASOCT) characteristics of different types of corneal and anterior chamber (AC) foreign bodies (FBs) and their usefulness in diagnosis and management. Methods: This is a retrospective descriptive clinical study involving 11 eyes of 11 patients who presented at the outpatient department of a tertiary ophthalmic care center from January 2017 to January 2022. All patients had a diagnosed or suspected corneal FB. All participants underwent a comprehensive ophthalmological examination, followed by slit-lamp photography and ASOCT. FB removal was done where required by an external, internal, or combined approach. Results: The mean age of ...

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    5. Increase in anterior chamber angle depth after topical pilocarpine measured by spectral domain optical coherence tomography: A possible additional indicator for laser peripheral iridotomy in primary angle-closure suspects in an opportunistic set-up

      Increase in anterior chamber angle depth after topical pilocarpine measured by spectral domain optical coherence tomography: A possible additional indicator for laser peripheral iridotomy in primary angle-closure suspects in an opportunistic set-up

      Purpose: Indication of laser peripheral iridotomy (LPI) is often conjectural due to dependency on gonioscopy and strict dichotomous classification of occludability. Indentation gonioscopy is the gold standard but is under-utilized for various reasons. The prevalence of primary angle closure disease (PACD) in eastern India is 1.5-1.9%, with a 22% five-year progression rate. Many angle closure patients may go blind without timely diagnosis and iridotomy. General ophthalmologists need alternate, validated methods for diagnoses. Pilocarpine eye drop causes miosis, and flattens the iris, producing angle changes detectable by spectral domain optical coherence tomography (SD-OCT). We hypothesized that the amount of ...

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    6. Comparison of peripapillary capillary plexus using optical coherence tomography angiography and retinal nerve fibre layer analysis using spectral domain optical coherence tomography in glaucoma patients, glaucoma suspects, and healthy subjects

      Comparison of peripapillary capillary plexus using optical coherence tomography angiography and retinal nerve fibre layer analysis using spectral domain optical coherence tomography in glaucoma patients, glaucoma suspects, and healthy subjects

      Purpose: To assess the association between radial peripapillary capillary (RPC) plexus using optical coherence tomography angiography (OCTA) and retinal nerve fibre layer (RNFL) thickness using spectral domain OCT (SD-OCT) in primary open-angle glaucoma (POAG) patients, glaucoma suspects, and healthy subjects. Methods: In this single-centre cross-sectional observational study, POAG, glaucoma suspects, and healthy patients underwent OCT-RNFL and optic nerve head angiography scans. The RNFL thickness and the vascular parameters obtained from RPC plexus, including perfusion density (PD), flux index (FI), and vessel density (VD), were analysed. Results: In all, 120 eyes of 120 patients, including 40 POAG patients, 40 glaucoma suspects ...

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    7. Assessment of Tear Meniscus Dimensions Using Anterior Segment Optical Coherence Tomography in Vitamin D Deficiency in a Pediatric Population

      Assessment of Tear Meniscus Dimensions Using Anterior Segment Optical Coherence Tomography in Vitamin D Deficiency in a Pediatric Population

      Background: To investigate of the effect of vitamin D (Vit-D) deficiency on the tear film in children and compare it with that of healthy subjects. Methods: This prospective and cross-sectional study comprised 75 eyes of children who had Vit-D deficiency (Group 1) and 85 eyes of age- and gender-matched healthy children (Group 2). The tear-film break-up time (TF-BUT) and Schirmer test values, as well as the Ocular Surface Disease Index (OSDI) scores were recorded for the participants in all of the groups. Measurement of the tear meniscus area (TMA) and tear meniscus height (TMH) was performed 2 times in the ...

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    8. Diagnostic ability of superficial vascular density measured by optical coherence tomography angiography to differentiate high myopic eyes from eyes with primary open angle glaucoma

      Diagnostic ability of superficial vascular density measured by optical coherence tomography angiography to differentiate high myopic eyes from eyes with primary open angle glaucoma

      Purpose: To determine if high myopia and glaucoma can be differentiated based on the measurement of superficial vascular density in the peripapillary and macular areas by using Optical Coherence Tomography Angiography (OCTA). Methods: This prospective, observational, cross-sectional, comparative study was conducted on patients between 40 and 60 years of age diagnosed as primary open-angle glaucoma (POAG) or high myopia and compared with age-matched controls. The main outcome measures were the difference in SVD% in peripapillary and macular areas in POAG and high myopic eyes. Detailed ophthalmic examination and OCTA of the disc and peripapillary area and macula were performed. The ...

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    9. Functional features in patients with idiopathic macular hole treatment via OCT angiography

      Functional features in patients with idiopathic macular hole treatment via OCT angiography

      To evaluate the optical coherence tomography (OCT) angiography features in patients with idiopathic macular hole (IMH) before and after vitrectomy. This prospective study included 25 patients diagnosed with IMH in Shanxi eye hospital from August 2019 to December 2021. The study was divided into 3 groups: IMH eyes, fellow eyes and normal eyes. All unilateral IMH eyes underwent vitrectomy. There were significant differences in superficial retinal blood flow density (SRBFD, P < .001) and choroidal blood flow density (CBFD) between IMH and healthy control eyes before operation (P < .05). There was significant difference in SRBFD between fellow eyes and normal eyes ...

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    10. Canadians are Skipping Regular Eye Exams Despite Available Vision Benefits

      Canadians are Skipping Regular Eye Exams Despite Available Vision Benefits

      Canadians who have unused vision benefits are urged to have a comprehensive eye exam before many annual benefits expire at the end of the year as Specsavers data reveals a concerning percentage of Canadians may be at risk for undetected eye disease because of missed eye exam appointments.... As part of Specsavers' commitment to accessible eyecare, and to better facilitate early detection of sight-threatening diseases, Specsavers makes OCT technology available as part of every comprehensive eye exam conducted by independent optometrists at Specsavers locations. The 3D eye scan using OCT technology is non-invasive and only takes a few seconds, allowing ...

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      Mentions: Specsavers
    11. Generative adversarial network-based deep learning approach in classification of retinal conditions with optical coherence tomography images

      Generative adversarial network-based deep learning approach in classification of retinal conditions with optical coherence tomography images

      Purpose: To determine whether a deep learning approach using generative adversarial networks (GANs) is beneficial for the classification of retinal conditions with Optical coherence tomography (OCT) images. Methods: Our study utilized 84,452 retinal OCT images obtained from a publicly available dataset (Kermany Dataset). Employing GAN, synthetic OCT images are produced to balance classes of retinal disorders. A deep learning classification model is constructed using pretrained deep neural networks (DNNs), and outcomes are evaluated using 2082 images collected from patients who visited the Department of Ophthalmology and the Department of Endocrinology and Metabolism at the Tri-service General Hospital in Taipei ...

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    12. Choroidal layer segmentation in OCT images by a boundary enhancement network

      Choroidal layer segmentation in OCT images by a boundary enhancement network

      Morphological changes of the choroid have been proved to be associated with the occurrence and pathological mechanism of many ophthalmic diseases. Optical Coherence Tomography (OCT) is a non-invasive technique for imaging of ocular biological tissues, that can reveal the structure of the retinal and choroidal layers in micron-scale resolution. However, unlike the retinal layer, the interface between the choroidal layer and the sclera is ambiguous in OCT, which makes it difficult for ophthalmologists to identify with certainty. In this paper, we propose a novel boundary-enhanced encoder-decoder architecture for choroid segmentation in retinal OCT images, in which a Boundary Enhancement Module ...

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    13. How to use three-dimensional optical coherence tomography effectively in coronary bifurcation stenting

      How to use three-dimensional optical coherence tomography effectively in coronary bifurcation stenting

      Imaging-guided coronary bifurcation intervention has improved clinical outcomes due to the appropriate size selection of the devices and optimization of the procedure (sufficient stent expansion, reduction of stent malapposition, appropriate stent landing zone, and detection of vessel dissection). In particular, three-dimensional optical coherence tomography (3D OCT) facilitates clear visualization of stent configuration and guidewire position, which promotes optimal guidewire crossing to the side branch. Successive side branch dilation leads to wide ostial dilation with less strut malapposition. However, the link connection of the stent located on the bifurcated carina has been found to be an impediment to sufficient opening of ...

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    14. Optical coherence tomography changes in ankylosing spondylitis patients on long-term adalimumab treatment

      Optical coherence tomography changes in ankylosing spondylitis patients on long-term adalimumab treatment

      OBJECTIVE: Long-term ocular effects of tumor necrosis factor-alpha inhibitors remain to be elucidated. This study aimed to examine the long-term effects of adalimumab use on neural tissue of the anterior visual pathways using optical coherence tomography in patients with ankylosing spondylitis. METHODS: This was a single-center, open-label, cross-sectional study conducted at the Giresun University Faculty of Medicine, Physical Medicine and Rehabilitation Department, between November 2019 and August 2020. This study included 26 ankylosing spondylitis patients receiving adalimumab for at least 1 year and 21 healthy controls. All subjects underwent a full ophthalmological examination and optical coherence tomography examination with the ...

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    15. Ganglion cell complex thickness with spectral domain optical coherence tomography and correlations in a normative pediatric South Asian cohort

      Ganglion cell complex thickness with spectral domain optical coherence tomography and correlations in a normative pediatric South Asian cohort

      Spectral domain optical coherence tomography (SD-OCT) was used to assess the perifoveal Ganglion cell complex (GCC) thickness in healthy Pakistani children. 174 eyes of 87 healthy children (3 to 16 years) were included after a thorough eye examination. Significant refractive error was excluded (>± 5 DS), glaucoma, ocular pathology, intraocular surgery, trauma, and systemic ailments. The perifoveal GCC analysis was done by Optopol Revo 80® high resolution SD-OCT. The average age was 11.1 ± 3.12 years. The average GCC thickness globally was 120.01 ± 76.74 μm, superiorly; 117.51 ± 8.77 μm, superonasally; 120.47 ± 8.78 μm, superotemporally ...

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  4. Picture Gallery

    Intraoperative Use of Wide-Field Optical Coherence Tomography to Evaluate Tissue Microstructure in the Oral Cavity and Oropharynx RetinAI launches Discovery CORE™: an AI-powered, collaborative platform to accelerate Clinical & Academic Research, & RWE analysis in ophthalmology A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals Photonic Advances Enhance Imaging Techniques Lymphography method based on time-autocorrelated optical coherence tomography Pre- and Post-doctoral Positions in Biomedical Optics and Biomechanics Opening at University of Houston Research Assistant / Research Associate Opening at University of Kent Diagnostic accuracy of OCTA and OCT for myopic choroidal neovascularisation: a systematic review and meta-analysis Assessment of optic disk by disk damage likelihood scale staging using slit-lamp biomicroscopy and optical coherence tomography in diagnosing primary open-angle glaucoma Central macular thickness and subfoveal choroidal thickness changes on spectral domain optical coherence tomography after cataract surgery in pediatric population Anterior segment optical coherence tomography characteristics and management of a unique spectrum of foreign bodies in the cornea and anterior chamber Increase in anterior chamber angle depth after topical pilocarpine measured by spectral domain optical coherence tomography: A possible additional indicator for laser peripheral iridotomy in primary angle-closure suspects in an opportunistic set-up
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu