1. Feature Of The Week: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

    Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. In this study, the diagnostic value of 3-D OCT in comparison to 2-D OCT in the comprehensive grading of human cartilage degeneration is investigated. In total, 53 human osteochondral samples were harvested. The imaging was performed by obtaining a single B-scan image (2-D OCT) and by collecting 100 consecutive B-scan images to generate a volumetric data set (3-D OCT). OCT images were assessed qualitatively according to a modified version of the DJD classification. OCT images were assessed quantitatively by algorithm-based evaluation of surface irregularity, tissue homogeneity and signal attenuation. In conclusion, the generation of 3-D volumetric datasets as well as multiple reconstructions such as rendering, surface topography, parametric and cross-sectional views proved to be of potential diagnostic value.

    For more information see recent Article. Courtesy of Nicolai Brill and Sven Nebelung from RWTH Aachen University. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Multi-wafer bonding technology for the integration of a micromachined Mirau interferometer

      Multi-wafer bonding technology for the integration of a micromachined Mirau interferometer

      The paper presents the multi-wafer bonding technology as well as the integration of electrical connection to the zscanner wafer of the micromachined array-type Mirau interferometer. A Mirau interferometer, which is a key-component of optical coherence tomography (OCT) microsystem, consists of a microlens doublet, a MOEMS Z-scanner, a focusadjustment spacer and a beam splitter plate. For the integration of this MOEMS device heterogeneous bonding of Si, glass and SOI wafers is necessary. Previously, most of the existing methods for multilayer wafer bonding require annealing at high temperature, i.e., 1100°C. To be compatible with MEMS devices, bonding of different material ...

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    2. Rotational MEMS mirror with latching arm for silicon photonics

      Rotational MEMS mirror with latching arm for silicon photonics

      We present an innovative rotational MEMS mirror that can control the direction of propagation of light beams inside of planar waveguides implemented in silicon photonics. Potential applications include but are not limited to optical telecommunications, medical imaging, scan and spectrometry. The mirror has a half-cylinder shape with a radius of 300 μm that provides low and constant optical losses over the full angular displacement range. A circular comb drive structure is anchored such that it allows free or latched rotation experimentally demonstrated over 8.5° (X-Y planar rotational movement) using 290V electrostatic actuation. The entire MEMS structure was implemented using ...

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    3. Macular thickness assessed with spectral domain OCT in a population-based study of children: normative data, repeatability and reproducibility and comparison with time domain OCT

      Macular thickness assessed with spectral domain OCT in a population-based study of children: normative data, repeatability and reproducibility and comparison with time domain OCT

      Purpose To collect data on macular thickness assessed with Cirrus OCT in healthy children in a population-based study, to examine the repeatability and reproducibility, and to compare the values with Stratus OCT. Methods Fifty-eight 6- to 15-year-old children, born at term, were examined. Best-corrected visual acuity and refraction were assessed. One examiner performed three OCT assessments, and the repeatability was calculated. Thereafter, a second examiner repeated the examinations to calculate the reproducibility. One eye was randomized to be included in the normal material. Finally, the second examiner assessed the macular thickness with the Stratus OCT. Results The mean value (±SD ...

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    4. Application of swept-source optical coherent tomography to caries diagnosis

      Application of swept-source optical coherent tomography to caries diagnosis

      Swept-source optical coherence tomography(SS-OCT) is a new imaging technology using optical light with the wavelengths around 1300nm. The SS-OCT provides us the 3 dimensional image with much higher resolution than dental X-ray. The extent of caries lesion is very clearly observed in the obtained image. The purposes of this article is to introduce the recent research on the SS-OCT imaging of tooth and to discuss the possibility of clinical application of the SS-OCT for diagnosing occlusal caries, inter-proximal caries, recurrent caries, root caries, cracks, and monitoring the early caries lesion.

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    5. A fully static OCT sensor using a glass integrated optic chip bonded to a CCD linear camera

      A fully static OCT sensor using a glass integrated optic chip bonded to a CCD linear camera

      A fully static OCT device is proposed. The glass integrated optic technology is used to have a large Fourier interferogram along an edge of the glass chip bonded on CCD linear detector array without protective glass window. After having described the system principles, first measurements will be presented. For that an optical signal coming from a SLED is divided in two equal parts injected respectively in a reference input and a probe input. It will be demonstrated that an optical phase difference measurement close to 600µm in the air can be achieved with an optical contrast of 30dB.

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    6. Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Objectives Fibrous cap thickness is the most critical component of plaque stability. Therefore, in vivo quantification of cap thickness could yield valuable information for estimating the risk of plaque rupture. In the context of preoperative planning and perioperative decision making, intracoronary optical coherence tomography imaging can provide a very detailed characterization of the arterial wall structure. However, visual interpretation of the images is laborious, subject to variability, and therefore not always sufficiently reliable for immediate decision of treatment. Methods A novel semiautomatic segmentation method to quantify coronary fibrous cap thickness in optical coherence tomography is introduced. To cope with the ...

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    7. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      Background and Objective Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography-based microangiography in detecting high-resolution, three-dimensional structural, and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. Materials and Methods A real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1,310 ...

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    8. Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Background:This study evaluated the ability of a newly developed integrated backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, Japan) to detect optical coherence tomography (OCT)-verified thin cap fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI).Methods and Results:One hundred culprit lesions in 100 consecutive patients with ischemic heart disease who consented to repeated IVUS and OCT prior to PCI were studied. Of 100 lesions, 48 had OCT-verified TCFA with a cap thickness <65 µm. Such lesions had larger percentage lipid area and lipid angle >2 quadrants on IB-IVUS. A ...

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    9. Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisen grade >2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups: non-atrophic papilledema and atrophic papilledema. Automated SD-OCT segmentation was performed on patients with non-atrophic papilledema and age-matched controls for each of the 9 regions of the Early Treatment Diabetic Retinopathy ...

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    10. Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Background Nobori is a biolimus A9-eluting stent (BES) featured with a biodegradable polymer coated on the abluminal side only. We previously reported that favorable vessel healing was achieved at 6-12 months after BES implantation. However, detailed long-term vessel reaction post-BES deployment is unclear. Methods Twenty-two BESs were serially evaluated by optical coherence tomography (OCT) at 6, 12, and 24 months post-stenting. Average neointimal thickness, uncovered struts and neointimal unevenness score (NUS: each cross section as maximum neointimal thickness in one cross section divided by the average neointimal thickness of the same cross-section) were manually measured. In addition, we evaluated the ...

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    11. Association between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography

      Association between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography

      Purpose: This study aimed to evaluate an association between hypertension and macular thickness. Methods: Eight hundreds and twenty-seven Korean adults composed of 163 pairs of twins and their family members were included in this population-based cross-sectional study. Macular thickness was measured with optical coherence tomography at nine macular subfields defined by the Early Treatment of Diabetic Retinopathy Study. Cardiometabolic risk factors, including body mass index (BMI), hypertension, diabetes, lipid profiles, and smoking status, were assessed. Linear mixed regression analysis was conducted with consideration of familial correlations and adjustment for covariates. Results: Age-, sex-, and axial length-adjusted analysis showed that systemic ...

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    12. Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

      Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

      Objective To evaluate the effect of pre-conditioning enamel white spot lesion (WSL) surfaces using bioactive glass (BAG) air-abrasion prior to remineralization therapy. Methods Ninety human enamel samples with artificial WSLs were assigned to three WSL surface pre-conditioning groups ( n = 30): (a) air-abrasion with BAG-polyacrylic acid (PAA-BAG) powder, (b) acid-etching using 37% phosphoric acid gel (positive control) and (c) unconditioned (negative control). Each group was further divided into three subgroups according to the following remineralization therapy ( n = 10): (I) BAG paste (36 wt.% BAG), (II) BAG slurry (100 wt.% BAG) and (III) de-ionized water (negative control). The average surface roughness and ...

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    13. Quantitative Analysis of Microdistortions in Bowman's Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections

      Quantitative Analysis of Microdistortions in Bowman's Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections

      PURPOSE: To quantitatively analyze the characteristics of Bowman’s layer microdistortions after femtosecond laser small incision lenticule extraction (SMILE) among different myopic corrections, and their correlations with stromal lenticule thickness. METHODS: In this nonrandomized, prospective, controlled study, 63 eyes of 32 consecutive patients undergoing SMILE were divided into three groups according to the preoperative spherical equivalent (SE): greater than −6.00 D (20 eyes), −3.00 to −6.00 D (26 eyes), and −3.00 D or less (17 eyes). Measurement by slit-lamp microscope, uncorrected distance visual acuity (UDVA), manifest refraction, and Fourier-domain optical coherence tomography (FD-OCT) were conducted preoperatively ...

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      Mentions: Fudan University
    14. Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      The authors report a new, non-invasive diagnostic method in the diagnosis of retinal cavernous hemangioma (RCH). A 6-year-old girl was referred for a non-clearing retinal hemorrhage of 6 months’ duration. Fourier-domain optical coherence tomography (FD-OCT) showed an intraretinal lesion with cystic-like internal appearance. Optical shadowing was present, preventing establishment of any subretinal component to the lesion. Swept-source OCT (SS-OCT) showed an intraretinal lesion consisting of a group of clearly defined grape-like caverns with overlying preretinal tissue. Wide-field fundus fluorescein angiography (WF-FFA) confirmed the diagnosis of RCH. SS-OCT was superior to FD-OCT in showing the internal anatomy of the RCH and ...

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    1. (3 articles) National Institutes of Health
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    1. (2 articles) Bioptigen
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    1. (1 articles) Heidelberg Spectralis
    2. (1 articles) Thorlabs OCT Imaging Systems
    3. (1 articles) LLTech Light-CT Scanner
    4. (1 articles) Imalux Niris
    5. (1 articles) Zeiss Stratus OCT
    6. (1 articles) Zeiss Cirrus HD-OCT
  6. Picture Gallery

    Technological platform for vertical multi-wafer integration of miniature imaging instruments Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice Optical coherence tomography for the diagnosis and evaluation of human otitis media Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography NASA presents Heidelberg Engineering the NASA Certificate of Appreciation Parametric imaging of viscoelasticity using optical coherence elastography Automated peroperative assessment of stents apposition from OCT pullbacks Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation
  7. Recent Quotes

    1. we are very proud of the fact that our systems development work allows ELAN Vascular to take their application to trial on diseased animals with the goals of the development project meet 100%.
      By Douglas Hamilton
    2. Ultimately, our goal is to try to understand how this pathway influences cardiac hypertrophy, not only within the context of specific conditions like Noonan syndrome, but also in the more general context of hypertension and high blood pressure, with the hopes of finding new targets to treat this disease.
      By Matthew J. Wolf
    3. Jon Holmes, Co-Founder, Michelson Diagnostics, added: “delighted that Andy has joined the team at Michelson as CEO. Our ability to attract a CEO with such impressive credentials is a testament both to the team’s achievements to date and to the potential commercial opportunity of the VivoSight OCT system in non-melanoma skin cancer. With Andy now on board to spearhead our commercial growth, I look forward to driving the VivoSight OCT technology development and clinical validation into other clinical applications where we believe it can make a significant impact on patient diagnosis and treatment monitoring.
      By Jon Holmes
    4. Our miniature OCT architecture, MRO™, can be implemented within the size, cost and power requirements of mobile and wearable devices...These new patents further expand our IP coverage of the space, providing partners and licensees robust protection for the investments they make in bringing products that incorporate MRO™ sensors to market.
      By Don Bogue
    5. Innovation in health care is an ongoing journey for all of us. The current state of change in the health care environment provides many opportunities to be more pioneering with our roles in providing the highest-quality care and most personalized experiences for our patients.
      By Marco A. Costa
    6. Marco epitomizes the ideal of a global physician-scientist who is, at heart, an innovator. He combines a scientific mindset with creativity to achieve extraordinary results.
      By Jeff Peters
    7. We are excited to add these two highly accomplished industry and academic leaders to round out our Board. Their strategic support and guidance will be key as we continue to advance our ophthalmology pipeline toward commercialization including our lead product candidate, EBI-005.
      By Abbie Celniker
    8. We are very pleased to receive this award from the NCBiotech Center... The work advanced under this loan will bring ophthalmic surgeons a step closer to realizing the full potential of intrasurgical OCT.
      By Eric L. Buckland
    9. I would recommend OCT together with arthroscopy in all situations as soon as there are enough studies (on their combined use) and it is available in veterinary medicine at a reasonable price.
      By Tytti Niemelä
    10. The USC Eye Institute is pioneering the development of novel treatments for eye diseases that cause vision loss and contributing critical scientific knowledge to advance the field of ophthalmology.
      By Carmen A. Puliafito