1. Recent Articles From Around The Web

    1. Photonics21 digs in for next phase of continental R&D

      Photonics21 digs in for next phase of continental R&D

      Laser pen for ‘while you wait' cancer test The Photonics21 team says that another successful PPP-related development has been delivered by the Automatic Detection of VAscular Networks for Cancer Evaluation (ADVANCE) project team. They have produced a portable laser scanner that can diagnose a malignant melanoma in less than one minute, promising to become what its developers describe as "the world‘s first while-you-wait test for skin cancer." The imaging system, intended to eliminate discomfort and uncertainty for patients, is able to fit every stage of disease identification within the short time of a single doctor's appointment. Using a ...

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    2. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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    3. Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Importance At one end of the coronary artery disease (CAD) spectrum, there are patients with multiple recurrent acute coronary syndromes (rACS), and at the other end there are those with long-standing clinical stability. Predicting the natural history of these patients is challenging because unstable plaques often heal without resulting in ACS. Objective To assess in vivo the coronary atherosclerotic phenotype as well as the prevalence and characteristics of healed coronary plaques by optical coherence tomography (OCT) imaging in patients at the extremes of the CAD spectrum. Design, Setting, and Participants This is an observational, single-center cohort study with prospective clinical ...

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    4. Cross-polarization optical coherence tomography for brain tumor imaging

      Cross-polarization optical coherence tomography for brain tumor imaging

      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) – OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An ...

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    5. Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Background / Objectives Automatic algorithms for stent struts segmentation in optical coherence tomography (OCT) images of coronary arteries have been developed over the years, particularly with application on metallic stents. The aim of this study is three-fold: (1) to develop and to validate a segmentation algorithm for the detection of both lumen contours and polymeric bioresorbable scaffold struts from 8-bit OCT images, (2) to develop a method for automatic OCT pullback quality assessment, and (3) to demonstrate the applicability of the segmentation algorithm for the creation of patient-specific stented coronary artery for local hemodynamics analysis. Methods The proposed OCT segmentation algorithm ...

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    6. Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Purpose Despite the controversial effect of elevated heart rate on progression of cardiac allograft vasculopathy (CAV), heart-rate-slowing agents are frequently prescribed with the assumption that higher heart rate predicts worse outcomes in cardiovascular disease. Methods This prospective 2-center trial investigated progression of CAV in 116 heart transplant (HTx) patients. Both baseline (1 month after HTx) and follow-up (12 months after HTx) examinations by coronary optical coherence tomography (OCT) were analyzed using highly automated 3D graph-based segmentation software. Mean heart rate was assessed by 24-hour ambulatory ECG monitoring at baseline and at 12-month follow-ups after HTx. Results During the first post-transplant ...

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    7. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Optical coherence tomography angiography (OCTA) has been widely used for <i>en face</i> visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the “tail” artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (<i>g</i><sub>1</sub>-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating arterioles from venules in the 3-D image. <i>g</i><sub>1</sub>   (  τ  )   is calculated from repeated optical coherence tomography (OCT) acquisitions for each spatial ...

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    8. Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Background/Purpose Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality used to assess coronary arteries and as an adjunctive tool for optimization of percutaneous coronary interventions. Overall, the rate of complications and adverse events related to intravascular imaging is low. Limited data exist on the most commonly reported complications and modes of failure related to the use of OCT. Therefore, we analyzed the post-marketing surveillance data from the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to assess the reported complications and failure modes for OCT and reviewed techniques to optimize device use. Methods ...

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    9. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Objectives Surgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic algorithm to improve on the current method of clinical evaluation of surgical margin in oral cancer. Materials and methods We have used a modified handheld OCT device with automated algorithm ...

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    10. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation remain poorly understood. Methods A total of 65 SCAD patients (68 vessels) who underwent acute OCT imaging as part of routine clinical care were included. Images were classified by the ...

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    11. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method is validated on phantoms composed of layers of different materials. Articular cartilage samples from adult swine are segmented with the method. The characteristics in each segmented zone are also examined ...

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    12. Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.

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    13. Distance, diameter and area determining device

      Distance, diameter and area determining device

      An elongated member such as a catheter that uses ultrasound or optical coherence tomography "OCT") technology to approximate the dimensions of a structure into which the catheter has been placed. The catheter includes multiple ultrasound transducers arranged in an annular or circumferential configuration on, embedded into or within the body of the elongated member so that distance measurements can be obtained between the elongated member and the wall of the immediately facing structure (e.g., a fluid-filled lumen). Utilizing these measurements, the present invention approximates for the physician the shape and size of the structure into which the elongated member ...

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    14. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the ...

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  2. Organizations in the News

    1. (3 articles) Center for Ophthalmic Optics and Lasers
    2. (3 articles) Oregon Health & Science University
    3. (3 articles) University of Western Australia
    4. (2 articles) UCLA
    5. (2 articles) Institute of Applied Physics
    6. (2 articles) Harvard University
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  3. People in the News

    1. (3 articles) David Huang
    2. (2 articles) Grigory V. Gelikonov
    3. (2 articles) Brendan F. Kennedy
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    5. (2 articles) Elena V. Zagaynova
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    13. (1 articles) Marcus P. Raele
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    15. (1 articles) Elliot M. Frohman
  4. OCT Companies in the News

    1. (1 articles) Topcon Medical Systems
    2. (1 articles) Conavi Medical Inc.
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    5. (1 articles) Michelson Diagnostics
    6. (1 articles) Canon Medical Systems
  5. Picture Gallery

    Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures Finger-mounted quantitative micro-elastography Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms? Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy Analysis of spatial resolution in phase-sensitive compression optical coherence elastography Postdoctoral/Research Fellow Opening at Australian National University The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly Functional retinal imaging using adaptive optics swept-source OCT at 1.6  MHz Local wavefront mapping in tissue using computational adaptive optics OCT Chief Technology Officer Opening at PhotoniCare
  6. Recent Quotes

    1. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    2. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden
    3. We are very excited and honored to partner with the team at Adachi. Adachi’s strong market presence in Otolaryngology, as well as their expertise in navigating Japanese regulatory and reimbursement pathways, will ensure a powerful launch of the TOMi Scope in the Japanese marketplace. We see this partnership as further validation of our technology and its potential to impact healthcare in a meaningful way. We look forward to a long and fruitful relationship with Adachi.
      By Ryan L. Shelton
    4. You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube...Many lesions in the mouth have been re-mineralized and...no longer need inter­vention,” said Fried. “Dentists have trouble telling the difference between active and arrested lesions; this new technology has the potential of differentiating them.
      By Daniel S. Fried
    5. OCT [already] has changed the practice of ophthalmol­ogy...It’s been very successful for retinal imaging...and it’s also very promising for dentistry...If the dentist doesn’t know if [a lesion] is active or arrested,” said Fried, “with OCT, you can actually see the lesion struc­ture, how deep it is and if it has a definitive surface zone suggesting that remineralization has occurred.
      By Daniel S. Fried
    6. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson
    7. Rox and I would like to take this opportunity to thank SPIE, program track chairs, conference chairs, and all of you in the com¬munity for the opportunity and the privilege to serve as co-chairs of BiOS all these years.
      By James G. Fujimoto
    8. Among the developments in the past 2 years, OCTA is by far the most important...Clinically, OCTA represents a paradigm change in angiography. It requires no dye injection, is faster (no waiting for dye transit), noninvasive, cheaper, and it can be used at every visit for screening and monitoring. OCTA will be used a lot more that fluorescein angiography ever was.
      By David Huang
    9. ATS9130 is a continuation of our effort to provide cost-effective yet powerful products to OEMs...ATS9130 provides data streaming, a feature that is usually absent in products in this price range.
      By Muneeb Khalid
    10. We see the power of OCT being utilized in several new areas, and appropriate software development tools are essential to speed up that progress. This software platform is a critical step in reaching our mission of OCT for all.
      By Nishant Mohan