Optical Coherence Tomography News

Feature Of The Week: Conical-Scan Polarization-Sensitive Optical Coherence Tomography (CS-PS-OCT)

We report on a new articular cartilage imaging technique with potential for clinical arthroscopic use, by supplementing the variable-incidence-angle polarization-sensitive optical coherence tomography method (VIA-PS-OCT) previously developed by us with a conical beam scan protocol. In the protocol, the beam is scanned such that the k-vector sweeps out a conical surface whose apex is chosen, for convenience, to lie at the tissue surface. In the implementation reported here we achieve this by mounting the sample on a motorized rotation stage with the sample surface roughly parallel to the stage rotating plane (i.e. normal to the stage rotation axis). The stage is mounted and tilted at a certain angle typically 45o with respect to the laser illumination beam direction. Conical scan PS-OCT (CS-PS-OCT) imaging is then obtained by acquiring successive A-scans over rotation spans of 0-360 degrees at an interval of 1 degree. During imaging the illumination beam is fixed and intersects the stage rotation axis at a fixed measurement point on the sample surface. Therefore, the azimuthal angle between the beam and the tissue normal varies continuously and a polar B-scan of depth-resolved retardance is plotted.

The technique is validated on bovine tendon by comparing experimental data with simulated data generated using the extended Jones matrix calculus. A unique capability of this new optical technique is that it can locate the “brushing direction” of collagen fibers in articular cartilage, which is structural information that extends beyond established methods such as split-line photography or birefringent fast-axis measurement in that it is uniquely defined over the full azimuthal-angle range of (-π, +π).

The technique could facilitate the translation of the VIA-PS-OCT technique to the clinic by simplifying the requirements for the beam delivery probe, e.g. launching a low numerical aperture (NA) beam into a high NA objective lens.

The mapping of this direction over the cartilage surface may offer insights into the optimal design of tissue-engineering scaffolds for cartilage repair, which are growing in sophistication through the use of additive manufacturing techniques. There is also an increasing interest in determining the regional structure of collagen fibers in cartilage in order to improve the accuracy of mechanical models of the tissue. New insights from CS-PS-OCT may then be of use in such studies.

For more information see recent Article. Courtesy Zenghai Lu and Stephen Matcher from the University of Sheffield. To share this article click Here.
Featured Articles
1. New Endoscopic Technology Helps Diagnose Esophageal Cancer Quickly
  
  Explore YouTube Apr 23 2014 Gastroenterology
  
  Esophageal cancer is one of the fastest growing cancer's in America and Pam Sain has been raising money to to raise awareness and get in the fight. After losing her father to esophageal cancer, she began the Taste of Point Orlando event to raise money. The proceeds from those events have gone to purchase new endoscopic technology to help diagnose esophageal cancer more quickly. Something Pam believes could have saved her father. Pam herself was one of the first patients to have an endoscopy with the new device as she is an acid reflux sufferer. To learn more visit ...
  Read Full Article
  
  Comment
  
  Mentions: NinePoint Medical NinePoint Nvision VLE Imaging System
2. Bioptigen Unveils the Envisu IntraSurgical OCT System for Real-time Imaging During Ophthalmic Surgery
  
  Explore Optical Coherence Tomography News Apr 22 2014 Other Business News
  
  Bioptigen Inc. today unveiled the Envisu IntraSurgical OCT for real-time imaging during ophthalmic surgical procedures. Key attributes of the Envisu IntraSurgical OCT include a wide, flat scan for accurate structural reproduction, and focal controls that operate independently of the microscope. These innovations will provide the surgeon with maximal versatility to assess surface and sub-surface tissue structures during surgical manipulations. Bioptigen’s Envisu IntraSurgical OCT is modularly designed for compatibility with new and existing operating microscopes to extend the power of OCT to surgical ophthalmology. "This advance brings surgeons one step closer to realizing the full value of intraoperative OCT", said ...
  Read Full Article
  
  Comment
  
  Mentions: Eric L. Buckland Bioptigen University of Miami
3. Two Postdoctoral Positions in Optical imaging at Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA
  
  Explore Optical Coherence Tomography News Apr 19 2014 Ophthalmology , Jobs & Studentships
  
  The Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University, is seeking outstanding candidates for the following positions in optical imaging research in the field of ophthalmology. v Post-Doc (hardware): develop optical imaging instruments Requirements: Skills in optics (optical design, microscope or fiber optics). Experience of programming with C++ or LabView for data acquisition and equipment control. Experience of optical coherence tomography (OCT) is desirable but not a must. PhD degree in a relevant discipline (Optics, Electrical Engineering, Biomedical Engineering, Physics). The successful candidate will be supervised by David Huang, MD, PhD and ...
  Read Full Article
  
  Comment
  
  Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers
4. Swept-source OCT and glaucoma
  
  Explore eyeworld.org Apr 18 2014 Ophthalmology , Tunable Sources
  
  A technology being investigated for use in posterior segment imaging may have a role in glaucoma diagnosis, according to the literature First there was time-domain optical coherence tomography (TD-OCT), then spectral-domain OCT (SD-OCT); now a newer technology—swept-source OCT—may be able to image structures that the previous technologies could not, according to researchers involved in clinical studies of the device. "With swept-source technology, a frequency swept light source and a high speed detector are used to detect the interference signal as a function of time, instead of a spectrometer and camera as in spectral-domain technology," explained James G. Fujimoto ...
  Read Full Article
  
  Comment
  
  Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto
5. Intra-operative OCT devices for ophthalmic use: an overview
  
  Explore Home - Springer Apr 17 2014 Ophthalmology
  
  It is feasible to bring the currently most used examination method in ophthalmology, optical coherence tomography (OCT), into ophthalmic surgery to enhance information and control for the surgeon and increase outcome for the patient. In this overview, the currently commercially available OCT devices intending intra-operative OCT imaging are described. Further experience with these systems might not only aid in solving current problems but also open our minds to detect processes so far unknown and help answer questions so far unaddressed.
  Read Full Article
  
  Comment
  
  Mentions: Optovue Heidelberg Engineering Cornell University
6. Measurement of wavefront aberrations and lens deformation in the accommodated eye with optical coherence tomography-equipped wavefront system
  
  Explore opticsinfobase.org Apr 16 2014 Ophthalmology
  
  To quantitatively approach the relationship between optical changes in an accommodated eye and the geometrical deformation of its crystalline lens, a long scan-depth anterior segment OCT equipped wavefront sensor was developed and integrated with a Badal system. With this system, accommodation was stimulated up to 6.0D in the left eye and also measured in the same eye for three subjects. High correlations between the accommodative responses of refractive power and the radius of the anterior lens surface were found for the three subjects (r>0.98). The change in spherical aberration was also highly correlated with the change in ...
  Read Full Article
  
  Comment
  
  Mentions: Jianhua Wang University of Miami
7. Virtual reality simulator for vitreoretinal surgery using integrated OCT data
  
  Explore Medical Journals Publisher Apr 15 2014 Ophthalmology
  
  Operative practice using surgical simulators has become a part of training in many surgical specialties, including ophthalmology. We introduce a virtual reality retina surgery simulator capable of integrating optical coherence tomography (OCT) scans from real patients for practicing vitreoretinal surgery using different pathologic scenarios.
  Read Full Article
  
  Comment
  
  Mentions: Igor Kozak
8. Assessment of early occlusal caries pre- and post- sealant application—An imaging approach
  
  Explore Wiley Online Library Apr 15 2014 Dentistry
  
  Background and Objective Clinicians have difficulty assessing and monitoring early occlusal caries. Traditional clinical exam and radiographs are unable to detect the subtle alterations in enamel indicative of de- or re-mineralization, particularly under dental sealants. Although clinicians have used laser fluorescence (LF) to address this gap, this modality has demonstrated weak correlation with histology. The International Caries Detection and Assessment System (ICDAS-II) has demonstrated high sensitivity and specificity for caries detection, but since it is based on visual assessment, it is of no use in areas beneath the most commonly used dental sealants which are opaque. Optical coherence tomography (OCT ...
  Read Full Article
  
  Comment
  
  Mentions: University of Michigan Zhongping Chen UC Irvine
9. Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views
  
  Explore Gastrointestinal Endoscopy Apr 13 2014 Gastroenterology
  
  This video (, available online at www.giejournal.org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett's esophagus.
  Read Full Article
  
  Comment
  
  Mentions: FDA
10. Postdoctoral Associate Position in Biophotonics at Stanford University
  
  Explore Optical Coherence Tomography News Apr 11 2014 Jobs & Studentships
  
  The Stanford Biomedical Optics Group (PI: Audrey K Ellerbee), in collaboration with clinical researchers in the School of Medicine (urology and embryology), seeks highly motivated postdoctoral candidates with a strong experimental background and solid theoretical preparation in optics, microscopy, medical imaging and image processing. Stanford University provides an outstanding environment for solid technical research with clinical impact. A postdoctoral position is available related to active research in the following areas: optical coherence tomography, endoscopic probe development, spectroscopy. Start date: Immediate. Term: Up to 2 years. Requirements: Applicants should have received a Ph.D. in Electrical Engineering, Physics / Applied Physics, Optics ...
  Read Full Article
  
  Comment
  
  Mentions: Stanford University Audrey K. Ellerbee
11. Expanding OCT: Quanitifying the Cornea’s Optical Performance
  
  Explore osa-opn.org Apr 11 2014 Ophthalmology
  
  Optical coherence tomography, a well-known method for imaging the retina, may allow physicians to perform quantitative metrology of the eye’s own optics. Swept-source OCT allows for simultaneous imaging of the cornea, iris and retina in living patients. Laser refractive surgeries such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) have brought better vision to tens of millions worldwide. But these techniques also exact a cost: because they work by reshaping the eye’s cornea, they make accurate measurement of the cornea’s optical parameters after surgery unreliable using conventional tools. That’s important, not only because inaccurate ...
  Read Full Article
  
  Comment
  
  Mentions: Joseph A. Izatt Duke University
12. Postdoctoral Research Fellowships in Optical Coherence Tomography at Wellman Center for Photomedicine Massachusetts General Hospital
  
  Explore Optical Coherence Tomography News Apr 10 2014 Jobs & Studentships
  
  A Postdoctoral research fellowship in the area of In Vivo Microscopy is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow at Harvard Medical School. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new in vivo microscopy technologies with applications in basic and clinical research. The fellowship will focus on the development and clinical application of advanced in vivo microscopy imaging ...
  Read Full Article
  
  Comment
  
  Mentions: Guillermo J. Tearney Massachusetts Institute of Technology Massachusetts General Hospital
13. Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography
  
  Explore Oxford Journals Apr 10 2014 Oncology
  
  Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiotherapy (IMRT) for a patient with choroidal metastasis from breast cancer with more accuracy than had been previously possible. We made replanning adaptive radiotherapy (ART) three times based on the rapid tumor shrinkage detected by weekly assessments with SS-OCT. Accordingly, the planning target volume (PTV) decreased from 1.6 cm 3 to 0.61 cm 3 (38%), with 0.95 cm 3 (59%) and ...
  Read Full Article
  
  Comment
  
  Mentions: Osaka University
14. St. Jude Medical Recognized as Innovative Technology Supplier of the Year by Nation’s Largest Health Care Contracting Organization
  
  Explore Optical Coherence Tomography News Apr 10 2014 Cardiology , Other Business News
  
  St. Jude Medical, Inc . ( STJ ), a global medical device company, was recognized by Novation as the 2013 Innovative Technology Supplier of the Year. Novation members selected the St Jude Medical ILUMIEN™ PCI Optimization System based on their experience using the technology to deliver improved patient outcomes. Novation works with its more than 100,000 members and affiliates to identify innovative technology that improves patient care or reduces the risk of harm to patients or providers, while simultaneously raising the standard of patient care and safety. “Novation’s goals of improving patient outcomes through innovative technology align with our mission at ...
  Read Full Article
  
  Comment
  
  Mentions: St. Jude Medical St. Jude Ilumien System
15. Business Forum: Professional society in our photonics ecosystem
  
  Explore Laser Focus World Apr 7 2014
  
  This is the second in a series of interviews of CEOs of our professional societies to give us a better understanding of the ecosystem of our industry. It is a pleasure for me to chat with Eugene Arthurs, someone I have known for more than 30 years. Arthurs is CEO of the International Society for Optics and Photonics after joining SPIE as executive director in 1999. Prior to this, he was president and CEO of Cleveland Crystals (CCI); before that, he was with Quantronix and Oriel. Arthurs received his B.Sc. with honors in Physics and his Ph.D. in ...
  Read Full Article
  
  Comment
  
  Mentions: California Institute of Technology Queen's University Belfast
16. Spatial Heterogeneity of Neoatherosclerosis, and its Relationship with Neovascularization and Adjacent Plaque Characteristics: Optical Coherence Tomography Study
  
  Explore American Heart Journal Apr 7 2014 Cardiology
  
  Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). NA was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results NA was more frequent in PS and ...
  Read Full Article
  
  Comment
  
  Mentions: University of Pittsburgh Massachusetts General Hospital Ik-Kyung Jang
17. Imalux Ceases Operation
  
  Explore Optical Coherence Tomography News Apr 3 2014 Other Business News
  
  Imalux Corporation has announced that it has ceased operations due to various challenges to become a profitable on-going business. Imalux Corporation was one of the earliest OCT startup companies and received its first seed funding in 2000. Imalux opened operations in Cleveland Ohio with a strong technology connection to the Institute of Applied Physics in Russia. With the visionary leadership of Paul Amazeen and Felix Feldchtein Imalux developed the Niris product line that offered unique endoscopy imaging capabilities. Niris systems were delivered to customer's worldwide offering physicians the ability to identify structural changes in tissues, guide surgical interventions and ...
  Read Full Article
  
  Comment
  
  Mentions: Paul Amazeen Imalux Felix I. Feldchtein
18. International Workshop on Tissue Phantoms and Standardization in Biophotonics at University of Maryland, May 21, 2014
  
  Explore Optical Coherence Tomography News Apr 3 2014
  
  The primary objective of the proposed scientific exchange and conference program is to facilitate development of phantom-based test methods, build a foundation upon which rigorous, least burdensome consensus standards can be achieved and ensure FDA’s readiness to evaluate innovative and emerging optical imaging technologies. A number of key challenges will be addressed in the proposed workshop. Currently, there is a general lack of knowledge in the biophotonics field regarding international consensus standards, including their importance and the extent and type of effort required for their development. Greater understanding and appreciation will likely lead to an increase in the amount ...
  Read Full Article
  
  Comment
  
  Mentions: University of Maryland University of Pittsburgh National Institutes of Health
19. NIDEK Announces FDA Clearance of the RS-3000 Advance
  
  Explore Optical Coherence Tomography News Apr 2 2014 Ophthalmology , Other Business News
  
  NIDEK, Inc. a global leader in the design, manufacturing, and distribution of ophthalmic equipment, is pleased to announce FDA clearance of the RS-3000 Advance . This premier OCT system incorporating Scanning Laser Ophthalmoscope is designed for comprehensive evaluation of the retina and choroid. The RS-3000 Advance provides exquisite detail of the retinal and choroidal microstructures to assist in clinical diagnosis. Features include the choroidal mode, which allows detailed evaluation of the choroid. A wide area scan of 9 mm x 9 mm ensures excellent overall coverage of the retinal structures. Microsaccades and other involuntary eye movements are compensated by the Tracing ...
  Read Full Article
  
  Comment
  
  Mentions: Nidek FDA Nidek RS-3000
20. MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Mar 31 2014 Dermatology , Funding
  
  MedLumics , a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, today announced the kick off of a three-year initiative to translate the latest OCT research into new clinical applications. Called the “BiopsyPen Project,” the effort is led by MedLumics and the Medical University of Vienna, with participation from a consortium of European members including VTT Finland, Delft University of Technology, Exalos AG, the Polytechnic University of Madrid, and Optocap Ltd. Together, the organizations are working to develop the second generation of a compact handheld diagnostic imaging system that will radically transform the capability of biophotonic technologies for ...
  Read Full Article
  
  Comment
  
  Mentions: Wolfgang Drexler Exalos Medical University of Vienna
21. NinePoint Medical Completes $34 Million Series B Financing to Expand Commercialization of its Breakthrough NvisionVLE™ Imaging System
  
  Explore Optical Coherence Tomography News Mar 19 2014 Gastroenterology , Funding , Other Business News
  
  NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced optical imaging, today announced it has completed a $34 million Series B financing led by Corning Incorporated (NYSE: GLW), along with founding investors Third Rock Ventures and Prospect Venture Partners. The company also announced the addition of three new members to its board of directors: Curt Weinstein from Corning, and independent directors Tom Miller and Mark Stautberg. Proceeds from the financing will support the ongoing commercial launch of the NvisionVLE Imaging System in the U.S., as well as development of the company’s expanded product ...
  Read Full Article
  
  Comment
  
  Mentions: Massachusetts General Hospital Boston Scientific Siemens
22. Eric Swanson Hot Topics presentation: Clinical Translation in OCT: Role of Research, Funding, and Entrepreneurism
  
  Explore Home: SPIE.org Mar 16 2014
  
  Eric Swanson discusses the migration of optical coherence tomography (OCT) into clinical practice in, "Clinical Translation in OCT: Role of Research, Funding, and Entrepreneurism." The translation from research to successful clinical impact is challenging and often the process passes through several stages including product development, initial sales and product iteration, market growth, and, finally, the next generation products. Each step can take several years, requiring persistence and perseverance on the parts of technologists and investors alike. The first release of a reliable, manufacturable, and supportable commercial product into the hands of clinicians is a critical milestone. It allows for fine ...
  Read Full Article
  
  Comment
  
  Mentions: Massachusetts Institute of Technology Eric A. Swanson NinePoint Medical
23. See all articles
Recent Articles From Around The Web
1. Intricacies in the analysis and interpretation of optical coherence tomography findings
  
  Explore eurointervention.org 13 min ago Cardiology
  
  The assessment of arterial wall healing following DES implantation with the use of optical coherence tomography (OCT) has become a standard in the systematic evaluation of coronary stents. As a result, the number of scientific manuscripts on stents and OCT has proliferated, and stent characteristics including strut coverage and malapposition are reported based on their association with stent thrombosis in observational studies1. In this issue of EuroIntervention, Kim and colleagues2 present the results of a randomised comparison between new-generation biodegradable biolimus-eluting stents…
  Read Full Article
  
  Comment
  
  Mentions: Stephan Windecker Bern University Hospital
2. The University of Illinois at Urbana-Champaign Announces Illinois Proof-of-Concept Program Award Recipients
  
  Explore businesswire.com 4 hours, 34 min ago Funding
  
  The Office of Technology Management (OTM) is proud to announce the 2014 awardees of the Illinois Proof-of-Concept (I-POC) Fund. I-POC enables development of projects that demonstrate an innovation’s market viability to potential investors and partners. Stephen Boppart , from the Beckman Institute for Advanced Science and Technology and the College of Engineering, for his Quantitative Pneumatic Otoscope , which uses optical coherence tomography (OCT) to visualize middle ear contents
  Read Full Article
  
  Comment
  
  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign
3. Subfoveal Choroidal Thickness in Patients with Chronic Heart Failure Analyzed by Spectral-Domain Optical Coherence Tomography
  
  Explore Informa Healthcare 7 hours, 13 min ago Ophthalmology
  
  Purpose : To evaluate the subfoveal choroidal thickness (SFCT) measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in eyes of chronic heart failure (CHF) patients. Methods : Fifty-six patients with CHF and 56 age- and gender-matched healthy individuals were enrolled. The SFCT was measured by EDI-OCT. The ejection fraction of left ventricle (EFLV), age, intraocular pressure (IOP), axial length (AL), systolic and diastolic blood pressure, and ocular perfusion pressure (OPP) were also measured. Results : Mean SFCT was 181.2 ± 80.23 μm in the study group and 283.6 ± 52.4 μm in the control group ( p = 0.000). There was ...
  Read Full Article
  
  Comment
4. Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm
  
  Explore SPIE | Journal 7 hours, 15 min ago Ophthalmology
  
  We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μ m, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument’s utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens ...
  Read Full Article
  
  Comment
  
  Mentions: Ruikang K. Wang
5. Agreement of Retinal Nerve Fiber Layer Defect Location Between Red-Free Fundus Photography and Cirrus HD-OCT Maps
  
  Explore Informa Healthcare 7 hours, 17 min ago Ophthalmology
  
  Purpose : To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. Methods : We examined 380 RNFL defects that showed clear margins in red-free fundus photographs. The OCT deviation and thickness maps were overlaid on the corresponding red-free fundus photographs. A reference line was drawn between the disc center and the macular center. Lines were also drawn between the optic disc center and the point where the RNFL defect margins crossed the OCT scan circle. The ...
  Read Full Article
  
  Comment
  
  Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT
6. Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus
  
  Explore Informa Healthcare 7 hours, 19 min ago Ophthalmology
  
  Purpose : New optical coherence tomography (OCT) devices with anterior segment module are able to measure the tear meniscus height (TMH) and tear meniscus area (TMA). Since the borders of the area and the height are to be marked by an examiner, the measurements are prone to be subjective. Herein, we aimed to evaluate the interexaminer reproducibility of the tear meniscus measurements with OCT. Materials and Methods : In this prospective cross-sectional study, both eyes of 300 consecutive patients with and without dry eye were studied. Following routine ophthalmologic examination, tear-film OCT images were obtained. Two examiners, who were unaware of the ...
  Read Full Article
  
  Comment
7. Monitor Corneal Epithelial Healing Under Bandage Contact Lens Using Ultrahigh-Resolution Optical Coherence Tomography After Pterygium Surgery
  
  Explore LWW Online Apr 23 2014 Ophthalmology
  
  Objective: To monitor corneal epithelial healing under bandage contact lens (BCL) using ultrahigh-resolution optical coherence tomography (UHR-OCT) after pterygium surgery. Methods: Thirty-nine eyes of 39 patients undergoing pterygium excision and conjunctival autografting were randomly allocated into 2 groups: 20 eyes were covered with silicone hydrogel BCLs at the end of surgery and 19 eyes served as a control. Ultrahigh-resolution optical coherence tomography scans of the cornea were performed sequentially at 1, 2, and 3 days, and then every other day until the end of re-epithelialization after surgery. Complete epithelial healing was verified with fluorescein staining examination after removal of BCLs ...
  Read Full Article
  
  Comment
  
  Mentions: Wenzhou Medical College Meixiao Shen
8. Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green
  
  Explore BJO Online Apr 23 2014 Ophthalmology
  
  Optical coherence tomography (OCT)-based visualisation of ophthalmic anatomy has transformed the clinical practice of ophthalmology. The translation of OCT into the surgical theatre is currently being actively researched and may provide a paradigm shift in surgical practice. Enhanced visualisation of tissues and tissue planes may provide further iterative improvement in surgeon feedback. Contrast-enhanced intraoperative OCT ( i OCT) has been previously described with triamcinolone. In this report, we describe the OCT features and contrast enhancement noted with indocyanine green using i OCT in human subjects as well as an ex vivo analysis in porcine eyes.
  Read Full Article
  
  Comment
  
  Mentions: Case Western Reserve University Cleveland Clinic Yuankai K. Tao
9. Detection of early changes in caries lesion using QLF-D and OCT
  
  Explore KoreaMed Synapse Apr 22 2014 Dentistry
  
  Objectives We aimed to compare the differences in caries lesion changes when measured by QLF-D as fluorescence loss and by SS-OCT as lesion depth with respect to demineralized time, during formation of artificial early caries lesion. We also demonstrated that QLF-D and SS-OCT can be used effectively in monitoring the longitudinal progression of simulated caries lesions. Methods Ten bovine incisors were sectioned (5×4 mm) and embedded in epoxy resin. An acid-resistant nail varnish was applied to a part of the tooth surfaces to protect sound enamel (2×4 mm). To generate lesions, each specimen was immersed in 40 ml ...
  Read Full Article
  
  Comment
  
  Mentions: Yonsei University
10. Relationship Between Presence of Foveal Bulge in Optical Coherence Tomographic Images and Visual Acuity After Rhegmatogenous Retinal Detachment Repair
  
  Explore LWW Online Apr 22 2014 Ophthalmology
  
  Purpose: To determine whether a significant correlation exists between the presence of a bulge in the photoreceptor inner segment/outer segment line and the best-corrected visual acuity in eyes after successful rhegmatogenous retinal detachment (RRD) repair. Methods: Patients who had undergone successful RRD repair and had an intact inner segment/outer segment line at the central fovea in the spectral-domain optical coherence tomographic images were retrospectively studied. Thirty-five eyes of 35 patients were evaluated, and the eyes were classified preoperatively into those with macula-on RRD (n = 14) and those with macula-off RRD (n = 21). Examination of the spectral-domain optical coherence ...
  Read Full Article
  
  Comment
11. Constructing 3D models of the pediatric upper airway from long range optical coherence tomography image
  
  Explore Conference Proceedings Apr 22 2014 Pulmonology
  
  Long-range optical coherence tomography has been developed to image the upper airway, obtaining high resolution, cross-sectional images of the hollow structure. The information obtained from the anatomical structure of the airway is important to objectively identify regions of airway obstruction. This paper describes a technique to create 3D reconstructions of the upper airway from LR-OCT images. Herein we outline the necessary steps to generate these 3D models, including image processing techniques, manual tissue segmentation in Mimics, anatomical curvature bending, and the final STL model rendition. These 3D models were used to qualitatively analyze structural changes before and after surgical interventions ...
  Read Full Article
  
  Comment
  
  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
12. Imaging of Naive Myopic Choroidal Neovascularization by Spectral-Domain Optical Coherence Tomography
  
  Explore Karger Publishers Apr 22 2014 Ophthalmology
  
  Purpose: To assess the tomographic features of myopic choroidal neovascularization by spectral-domain optical coherence tomography. Methods: We consecutively reviewed the charts of patients with pathologic myopia, recent visual acuity deterioration and active macular neovascularization. Specific tomographic changes were studied in 25 eyes by two authors independently. Results: The mean age of patients eligible for the study was 63.4 (±18.2) years. Main tomographic outcomes were the hyperreflectivity of the lesion in 88% of cases (95% CI 0.74-1.02), absence of the external limiting membrane in 88% (95% CI 0.84-1.02), and retinal thickening in 83% (95% CI ...
  Read Full Article
  
  Comment
  
  Mentions: Luisa Pierro
13. Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach
  
  Explore Optical Coherence Tomography News Apr 22 2014 Ophthalmology , Funding
  
  Iowa City VA Received a 2014 NIH Grant for Glaucoma Assessment using a Multimodality Image Analysis Approach. The principle investigator is Mona Garvin. The program began in 2012 and ends in 2015. Below is a summary of the proposed work. This Career Development Award-2 (CDA-2) is for supporting an early-career engineering faculty member for three years. It will provide the means to train a young researcher currently possessing broad image analysis experience and narrowly focused expertise in one ophthalmic imaging modality (optical coherence tomography, OCT) in a multitude of ophthalmic modalities and clinical areas, with a special focus on glaucoma ...
  Read Full Article
  
  Comment
  
  Mentions: University of Iowa Mona K. Garvin
14. Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy
  
  Explore LWW Online Apr 22 2014 Ophthalmology
  
  Purpose: To determine the effects of diabetic retinopathy (DR), increased foveal thickness (FT), and adaptive optics (AO) on wavefront aberrations and Shack-Hartmann (SH) image quality. Methods: Shack-Hartmann aberrometry and wavefront error correction were performed with a bench-top AO retinal imaging system in 10 healthy control and 19 DR subjects. Spectral domain optical coherence tomography was performed and central FT was measured. Based on the FT data in the control group, subjects in the DR group were categorized into two subgroups: those with normal FT and those with increased FT. Shack-Hartmann image quality was assessed based on spot areas, and high-order ...
  Read Full Article
  
  Comment
15. Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma
  
  Explore jdcr.eu Apr 22 2014 Dermatology
  
  Over the past few years melanoma has grown into a disease of socio-economic importance due to the increasing incidence and persistently high mortality rates. Melanoma is a malignant tumor with a high tendency to metastasize. Therefore, an extremely important part of the therapeutic process is to identify the disease at an early stage: in situ or stage I. Many tools for early diagnosis of melanoma are available today, including dermoscopy, videodermoscopy and in vivo reflectance confocal microscopy. Other methods such as high frequency ultrasound, optical coherence tomography and electrical impedance spectroscopy may serve as additional diagnostic aids. Modern imaging techniques ...
  Read Full Article
  
  Comment