1. Featured Articles

    1. PhD studentship in AI-Enabled OCT at Liverpool University, UK

      Explore Optical Coherence Tomography News Jobs & Studentships
      PhD studentship in AI-Enabled OCT at Liverpool University, UK

      An EPSRC funded PhD studentship is available in the Laboratory of Professor Shen of Department of Electrical Engineering and Electronics, Liverpool University, UK. This project aims to develop artificial intelligence (AI)-enabled OCT techniques for imaging the corneal nerves in a non-contact manner. The candidate will be expected to refine and optimise the novel OCT instrumentation to achieve the required resolution and speed for imaging corneal nerves. The successful PhD candidate will benefit from working with a multidisciplinary team covering areas of imaging technology, AI and computer science, tissue engineering and medicine. Applicants should have (or expect to obtain by ...

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    2. Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis

      Applications are invited for a post-doctoral research associate position in the UC Davis EyePod Small Animal Ocular Imaging Laboratory affiliated with Center for Vision Science ( http://cvs.ucdavis.edu ) at the UC Davis Main Campus. The goal of our research is to develop and translate the next generation in vivo cellular resolution multimodal retinal imaging instruments and data analysis tools from basic science to clinics and to apply them to in vivo study of disease mechanisms and therapeutic interventions. The ideal candidate will have strong skills in some combination of retinal/microscopic imaging modalities, including OCT, SLO, multispectral imaging, fluorescence ...

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      Mentions: UC Davis Robert J. Zawadzki

    3. Remote monitoring with Home OCT

      Explore intravitrealexperts.com Ophthalmology
      Remote monitoring with Home OCT

      In this video, Anat Loewenstein, MD, MHA, speaks about a Home OCT device. This technology has been tested in studies, and patients have been given the chance to try it at home, following a few, simple instructions. Some of them also speak here. Home monitoring is one of the most promising new frontiers in healthcare, leading to: reduced number of patient visits reduced patient burden increased safety in the time of COVID-19 more frequent, consistent gathering and assessment of data timely, personalized treatment schedules

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      Mentions: Notal Vision

    4. Myths Associated With Optical Coherence Tomography for Glaucoma

      Explore glaucomaphysician.net Ophthalmology
      Myths Associated With Optical Coherence Tomography for Glaucoma

      D onald C. Hood, PhD, is the James F. Bender Professor of Psychology and Professor of Ophthalmic Sciences at Columbia University in New York, New York. His work has focused on improving the utility of optical coherence tomography (OCT) imaging in glaucoma treatment. He lectures on the lessons he has learned about the use of OCT, and how these lessons can aid the clinician in understanding and diagnosing glaucoma. Here, Glaucoma Physician talks with Dr. Hood about myths he believes glaucoma specialists hold about OCT for glaucoma. Q: How is OCT currently used in glaucoma management? A: Optical coherence tomography ...

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      Mentions: Columbia University Donald C. Hood

    5. Susana Marcos to lead Center for Visual Science

      Explore University of Rochester Ophthalmology
      Susana Marcos to lead Center for Visual Science

      Internationally recognized pioneer in vision science and its applications is named the next director of one of the University’s most highly regarded research centers. (Courtesy of Susana Marcos) Susana Marcos, an internationally recognized expert in the optics of the eye and the interactions of light with the retina, will become the David R. Williams Director of the Center for Visual Science at the University of Rochester . Her appointment will take effect July 1. The named position is endowed with a $2 million gift from John and Barbara Bruning. John, a member of the University’s Board of Trustees and ...

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      Mentions: University of Rochester Susana Marcos P. Scott Carney

    6. Material-specific imaging of nanolayers using extreme ultraviolet coherence tomography

      Explore OSA | OSA Publishing NDE/NDT , Other Business News
      Material-specific imaging of nanolayers using extreme ultraviolet coherence tomography

      Scientific and technological progress depend substantially on the ability to image on the nanoscale. In order to investigate complex, functional, nanoscopic structures like, e.g., semiconductor devices, multilayer optics, or stacks of 2D materials, the imaging techniques not only have to provide images but should also provide quantitative information. We report the material-specific characterization of nanoscopic buried structures with extreme ultraviolet coherence tomography. The method is demonstrated at a laser-driven broadband extreme ultraviolet radiation source, based on high-harmonic generation. We show that, besides nanoscopic axial resolution, the spectral reflectivity of all layers in a sample can be obtained using algorithmic ...

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    7. A sharper look at the interior of semiconductors

      Explore PhysOrg.com Ophthalmology
      A sharper look at the interior of semiconductors

      Images provide information—what we can observe with our own eyes enables us to understand. Constantly expanding the field of perception into dimensions that are initially hidden from the naked eye, drives science forward. Today, increasingly powerful microscopes let us see into the cells and tissues of living organisms, into the world of microorganisms as well as into inanimate nature. But even the best microscopes have their limits. "To be able to observe structures and processes down to the nanoscale level and below, we need new methods and technologies," says Dr. Silvio Fuchs from the Institute of Optics and Quantum ...

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    8. Integrated Quad-Scanner Strategy-Based Optical Coherence Tomography for the Whole-Directional Volumetric Imaging of a Sample

      Explore MDPI Open Access Journals Platform
      Integrated Quad-Scanner Strategy-Based Optical Coherence Tomography for the Whole-Directional Volumetric Imaging of a Sample

      Whole-directional scanning methodology is required to observe distinctive features of an entire physical structure with a three dimensional (3D) visualization. However, the implementation of whole-directional scanning is challenging for conventional optical coherence tomography (OCT), which scans a limited portion of the sample by utilizing unidirectional and bidirectional scanning methods. Therefore, in this paper an integrated quad-scanner (QS) strategy-based OCT method was implemented to obtain the whole-directional volumetry of a sample by employing four scanning arms installed around the sample. The simultaneous and sequential image acquisition capabilities are the conceptual key points of the proposed QS-OCT method, and were implemented using ...

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      Mentions: Jeehyun Kim Kyungpook National University Ruchire Eranga Wijesinghe

    9. Forensic Problems, Optical Solutions

      Explore osa-opn.org NDE/NDT
      Forensic Problems, Optical Solutions

      Since first hitting the scene in 1991, optical coherence tomography (OCT) has become a leviathan among biomedical imaging techniques, due to the method’s nondestructive ability to resolve layers of tissue. In ophthalmology, especially, OCT has been revolutionary, imaging retinal layers noninvasively through an approximately one-inch-thick watery window—the human eye. Now, U.K. researchers in applied optics, forensic science and the document-examination industry have joined forces to apply OCT to the high-resolution subsurface analysis of multilayered identification documents (Sci. Justice, doi: 10.1016/j.scijus.2020.12.001 ). The method can reportedly detect forged passports or national ID cards ...

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  2. Recent Articles From Around The Web

    1. On-Chip Beam Splitting Strategies Based on SWG Assisted Directional Coupler for 850 nm Optical Coherence Tomography - A Numerical Study

      Explore IEEE Xplore
      On-Chip Beam Splitting Strategies Based on SWG Assisted Directional Coupler for 850 nm Optical Coherence Tomography - A Numerical Study

      A subwavelength gratings (SWG) assisted directional coupler (DC) is proposed to work as beam splitter (BS) for 850 nm chip-based optical coherence tomography (OCT). The bandwidth of the SWG assisted DC is maximized to 110 nm by selecting appropriate SWG geometries including its duty cycle and period. The axial point spread functions (PSFs) derived from the BS transmittances proves the optimized bandwidth is broad enough to support axial resolution higher than 4 μ m . Meanwhile, the SWG period can be manipulated to match the center wavelength between BS and light source so that the wavelength mismatching induced resolution degradation is effectively ...

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    2. Role of Optical Coherence Tomography Angiography in Following-up Choroidal Neovascular Membranes during the Course of Aflibercept Therapy

      Explore journaljammr.com Ophthalmology
      Role of Optical Coherence Tomography Angiography in Following-up Choroidal Neovascular Membranes during the Course of Aflibercept Therapy

      Aims: To evaluate the mean area of choroidal neovascularization (CNV) and the flow area within the CNV and determine their value in monitoring the effect of aflibercept therapy. Study Design: prospective, interventional study. Place and Duration of Study: Tanta University Hospital in the period between March 2017 and March 2019. Methodology: OCT angiography images were obtained using the AngioVue (Optovue Inc., CA, USA). For quantitative analysis of the mean area of CNV and the flow area within the CNV, the CNV was manually delineated with the help of the manufacturer’s automated software, and the parameters of interest were automatically ...

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      Mentions: Optovue

    3. An Update on Choroidal Layer Segmentation Methods in Optical Coherence Tomography Images: a Review

      Explore jbpe.sums.ac.ir Ophthalmology
      An Update on Choroidal Layer Segmentation Methods in Optical Coherence Tomography Images: a Review

      Choroid is one of the structural layers, playing a significant role in physiology of the eye and lying between the sclera and the retina. The segmentation of this layer could guide ophthalmologists in diagnosing most of the eye pathologies such as choroidal tumors and polypoidal choroidal vasculopathy. High signal-to-noise ratio and high speed imaging in Spectral-Domain Optical Coherence Tomography (SD-OCT) make choroidal imaging feasible. Several variables such as pre-operative axial length (AXL), time of day and age affect thickness of the choroidal vascularization and should be considered for segmentation of this layer. These days most of the eye specialists manually ...

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    4. Stalagmite-like pre-retinal deposits in the optical coherence tomography of two vitrectomy patients with panuveitis

      Explore ScienceDirect Ophthalmology
      Stalagmite-like pre-retinal deposits in the optical coherence tomography of two vitrectomy patients with panuveitis

      Two patients with panuveitis are presented in whom, after undergoing a vitrectomy, the optical coherence tomography (OCT) revealed some unusual pre-retinal hyper-reflective deposits with the shape of stalagmites, distributed in a multifocal and perivascular pattern. Case 1: 51-year-old male with panuveitis in the right eye. After diagnostic-therapeutic vitrectomy, OCT showed pre-retinal stalagmite-like deposits. There was no clear aetiology, and the deposits persisted over the time. Case 2: 76-year-old woman with panuveitis in the right eye. After a surgery for cataract-vitrectomy and epiretinal membrane peeling, OCT revealed pre-retinal stalagmite-like deposits. The analysis reported elevated Toxoplasma IgG titres. Clarithromycin and corticosteroid were ...

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    5. In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      Explore SPIE Digital Library Dermatology
      In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      Significance: Melanocytic nevi represent the most common dermal melanocytic lesions in humans. Nevus is typically diagnosed clinically with the naked eye or with dermoscopy. However, it is essential to identify the type of nevus by invasive biopsy for histopathological examination. The use of noninvasive imaging tools can be used to evaluate the types of nevi to reduce unnecessary excisions of benign entities. Aim: To evaluate the feasibility of using en face and cross-sectional full-field optical coherence tomography (FF-OCT) in differentiation of melanocytic nevi that can facilitate the reduction of unnecessary excisions of benign entities. Approach: Dual-mode Mirau-type FF-OCT for cross-sectional ...

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    6. Changes in peripapillary and macular vascular density after laser selective trabeculoplasty: an optical coherence tomography angiography study

      Explore Wiley Online Library Ophthalmology
      Changes in peripapillary and macular vascular density after laser selective trabeculoplasty: an optical coherence tomography angiography study

      Objectives: To determine the effect of laser trabeculoplasty on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT-A). Methods: This was a prospective observational study performed at the Glaucoma Research Centre, Montchoisi Clinic, Lausanne, Switzerland. Thirty-seven eyes with primary open-angle glaucoma from 21 patients were included. Optical coherence tomography angiography (OCT-A) scans were performed before laser trabeculoplasty and at 2 and 6 months after the procedure. AngioVue AngioAnalytic (Optovue Inc, Fremont, CA, USA) software was used to analyse the RNFL, FAZ, peripapillary and ...

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      Mentions: Optovue Harsha L. Rao

    7. Application of optical coherence tomography to study the structural features of oral mucosa in biopsy tissues of oral dysplasia and carcinomas

      Explore Home - Springer
      Application of optical coherence tomography to study the structural features of oral mucosa in biopsy tissues of oral dysplasia and carcinomas

      Objective: This study aims to examine the ability of optical coherence tomography (OCT) to differentiate ex vivo epithelial structure of benign disorders, dysplastic, and oral squamous cell carcinoma (OSCC) in comparison with the structure of normal marginal mucosa of oral biopsies. As a secondary objective, we examined the inter- and intra-observer variations of OCT measurements of two calibrated assessors. Materials and methods: Oral biopsies (n = 44) were scanned using the swept source OCT (SSOCT) and grouped by pathology diagnosis to benign, dysplasia or carcinoma. Two trained and calibrated assessors scored on the five OCT variables: thickness of keratin layer (KL ...

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    8. Kinetic and static perimetry after 16 years and additional OCT-A analysis in eyes with long-lasting optic disc drusen

      Explore Journals | PLOS Ophthalmology
      Kinetic and static perimetry after 16 years and additional OCT-A analysis in eyes with long-lasting optic disc drusen

      The aim of the study is to evaluate the progression of visual field (VF) defects over 16 years of observation and to assess abnormalities in vessels and retinal nerve fibre layer (RNFL) thickness in patients with optic disc drusen (ODD). Both static automated perimetry (SAP) and semi-automated kinetic perimetry (SKP) were performed in 16 eyes of 8 patients (mean age 54 years) with ODD among 26 eyes of 13 patients examined 16 years before. The area of I2e, I4e, III4e, and V4e isopters was measured in deg2. The MD and PSD parameters were estimated using SAP. Optical coherence tomography angiography ...

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    9. On the Nature of Murine Radiation-Induced Subcapsular Cataracts: Optical Coherence Tomography-Based Fine Classification, In Vivo Dynamics and Impact on Visual Acuity

      Explore Allen Press Developmental Biology , Ophthalmology
      On the Nature of Murine Radiation-Induced Subcapsular Cataracts: Optical Coherence Tomography-Based Fine Classification, In Vivo Dynamics and Impact on Visual Acuity

      Ionizing radiation is widely known to induce various kinds of lens cataracts, of which posterior subcapsular cataracts (PSCs) have the highest prevalence. Despite some studies regarding the epidemiology and biology of radiation-induced PSCs, the mechanism underscoring the formation of this type of lesions and their dose dependency remain uncertain. Within the current study, our team investigated the in vivo characteristics of PSCs in B6C3F1 mice (F1-hybrids of BL6 × C3H) that received 0.5–2 Gy γ-ray irradiation after postnatal day 70. For purposes of assessing lenticular damages, spectral domain optical coherence tomography was utilized, and the visual acuity of the ...

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    10. Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

      The purpose of this research study is to develop a better understanding of vascular stains and to improve the usual laser treatment for vascular stain by using optical coherence tomography (OCT). This study is being done at the University of Wisconsin-Madison (UW-Madison) and University of California, Irvine. A total of about 85 people will participate in this study.

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      Mentions: University of Wisconsin

    11. Refractive Precision of Ray Tracing IOL Calculations Based on OCT Data versus Traditional IOL Calculation Formulas Based on Reflectometry in Patients with a History of Laser Vision Correction for Myopia

      Explore Medical Journals Publisher Ophthalmology
      Refractive Precision of Ray Tracing IOL Calculations Based on OCT Data versus Traditional IOL Calculation Formulas Based on Reflectometry in Patients with a History of Laser Vision Correction for Myopia

      Purpose: To compare the refractive predictability of ray tracing IOL calculations based on OCT data versus traditional IOL calculation formulas based on reflectometry in patients with a history of previous myopic laser vision correction (LVC). Patients and Methods: This was a prospective interventional single-arm study of IOL calculations for cataract and refractive lens exchange (RLE) patients with a history of myopic LVC. Preoperative biometric data were collected using an optical low coherence reflectometry (OLCR) device (Haag-Streit Lenstar 900) and two optical coherence tomography (OCT) devices (Tomey Casia SS-1000 and Heidelberg Engineering Anterion). Traditional post LVC formulas (Barret True-K no-history and ...

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      Mentions: Tomey Corporation Haag-Streit

    12. Assessing accommodative presbyopic biometric changes of the entire anterior segment using single swept-source OCT image acquisitions

      Explore Nature Publishing Group Ophthalmology
      Assessing accommodative presbyopic biometric changes of the entire anterior segment using single swept-source OCT image acquisitions

      Background/Objectives To evaluate biometric changes throughout the anterior chamber during accommodation and presbyopia using single image acquisition swept-source anterior-segment optical coherence tomography (AS-OCT). Subject/Methods Anterior-segment images were obtained using a new swept-source AS-OCT device (ANTERION, Heidelberg Engineering) from healthy volunteers ( n  = 71) across two centers in this prospective observational case series. In one image acquisition, cornea through posterior lens, including the ciliary muscle on both sides of the right eye, was imaged. Subjects undertook no accommodative effort and −1, −3, and −5 D of target vergence. Two-way repeated measures ANOVA modeling was performed for ciliary muscle measurements, lens ...

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      Mentions: Heidelberg Engineering University of Southern California Srinivas R. Sadda

    13. Customized Slab-Segmentation Method for Projection-Artifact Elimination in Best Vitelliform Macular Dystrophy: A Swept-Source Optical Coherence Tomography Angiography Study

      Explore Medical Journals Publisher Ophthalmology
      Customized Slab-Segmentation Method for Projection-Artifact Elimination in Best Vitelliform Macular Dystrophy: A Swept-Source Optical Coherence Tomography Angiography Study

      Purpose: To assess the efficacy of customized slab segmentation in eliminating projection artifacts in swept-source optical coherence tomography angiography (SS-OCTA) images of Best vitelliform macular dystrophy (BVMD). Methods: Prospective case series including different stages of BVMD. We analyzed SS-OCTA images for flow signals in the outer retina and coregistered B-scan images for distortion of the segmentation slabs defining the outer retina. We applied a customized method for slab realignment whenever BVMD lesions produced distortion of the slabs. Afterward, we checked the images to determine whether the previously noted flow signal had persisted or disappeared, described as “true flow” or “pseudoflow ...

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    14. Corneal Epithelial Thickness Profile in Healthy Portuguese Children by High-Definition Optical Coherence Tomography

      Explore Medical Journals Publisher Ophthalmology
      Corneal Epithelial Thickness Profile in Healthy Portuguese Children by High-Definition Optical Coherence Tomography

      Introduction and Objective: To evaluate corneal epithelial thickness (ET) and corneal thickness (CT) profiles in healthy eyes of Portuguese children and provide information to establish the first normative Caucasian database for these age group. Methods: Sixty healthy eyes of 60 children aged between 8 and 18 were evaluated using the Cirrus high-definition optical coherence tomography device. The average ET and CT were assessed using Cirrus Review Software with predefined concentric corneal ring-shaped zones. Specific regions of ET (central, superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal and inferonasal) were also assessed. The mean ET, the mean CT and the difference of ...

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    15. Prediction model for best focus, power, and spherical aberration of the cornea: Raytracing on a large dataset of OCT data

      Explore Journals | PLOS Ophthalmology
      Prediction model for best focus, power, and spherical aberration of the cornea: Raytracing on a large dataset of OCT data

      Purpose To analyse corneal power based on a large optical coherence tomography dataset using raytracing, and to evaluate corneal power with respect to the corneal front apex plane for different definitions of best focus. Methods A large OCT dataset (10,218 eyes of 8,430 patients) from the Casia 2 (Tomey, Japan) was post-processed in MATLAB (MathWorks, USA). Using radius of curvature, corneal front and back surface asphericity, central corneal thickness, and pupil size (aperture) a bundle of rays was traced through the cornea. Various best focus definitions were tested: a) minimum wavefront error, b) root mean squared ray scatter ...

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      Mentions: Tomey Corporation Saarland University
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    1. (2 articles) Columbia University
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    PhD studentship in AI-Enabled OCT at Liverpool University, UK Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis Remote monitoring with Home OCT Myths Associated With Optical Coherence Tomography for Glaucoma Susana Marcos to lead Center for Visual Science Material-specific imaging of nanolayers using extreme ultraviolet coherence tomography A sharper look at the interior of semiconductors Integrated Quad-Scanner Strategy-Based Optical Coherence Tomography for the Whole-Directional Volumetric Imaging of a Sample Forensic Problems, Optical Solutions On-Chip Beam Splitting Strategies Based on SWG Assisted Directional Coupler for 850 nm Optical Coherence Tomography - A Numerical Study Role of Optical Coherence Tomography Angiography in Following-up Choroidal Neovascular Membranes during the Course of Aflibercept Therapy An Update on Choroidal Layer Segmentation Methods in Optical Coherence Tomography Images: a Review

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    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
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