1. Recent Articles From Around The Web

    1. GaAs-Based Superluminescent Light-Emitting Diodes with 290-nm Emission Bandwidth by Using Hybrid Quantum Well/Quantum Dot Structures

      GaAs-Based Superluminescent Light-Emitting Diodes with 290-nm Emission Bandwidth by Using Hybrid Quantum Well/Quantum Dot Structures

      A high-performance superluminescent light-emitting diode (SLD) based upon a hybrid quantum well (QW)/quantum dot (QD) active element is reported and is assessed with regard to the resolution obtainable in an optical coherence tomography system. We report on the appearance of strong emission from higher order optical transition from the QW in a hybrid QW/QD structure. This additional emission broadening method contributes significantly to obtaining a 3-dB linewidth of 290 nm centered at 1200 nm, with 2.4 mW at room temperature.

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    2. Observation of drying process of multilayered paint using fOCT based on dynamic speckles

      Observation of drying process of multilayered paint using fOCT based on dynamic speckles

      Recently, a demand for the precise observation of a multilayered paint system have been increasing such as in car industry. However, conventional methods can observe only the surface condition of the paint. In this study, we propose a new method to observe a three dimensional drying process of the multilayered paint using functional Optical Coherence Tomography (fOCT). In this method, the dynamic speckles that appear in OCT signal were utilized. The temporal properties of the dynamic speckle is related to the Brownian motion of the scattering particles in the paint, and thus depends on the drying condition. Autocorrelation function of ...

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    3. Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Purpose : Quantification of retinal layers using automated segmentation of optical coherence tomography (OCT) images allows for longitudinal studies of retinal and neurological disorders in mice. The purpose of this study was to compare the performance of automated retinal layer segmentation algorithms with data from manual segmentation in mice using the Spectralis OCT. Methods : Spectral domain OCT images from 55 mice from three different mouse strains were analyzed in total. The OCT scans from 22 C57Bl/6, 22 BALBc, and 11 C3A.Cg- Pde6b + Prph2 Rd2 /J mice were automatically segmented using three commercially available automated retinal segmentation algorithms and compared ...

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    4. Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques

      The accurate observation of physiological changes on in vivo samples of important animal species such as Euphausia superba (Antarctic krill) is an important goal in helping to understand how environmental changes can affect animal development. Using a custom made ‘krill trap’, live un-anaesthetized krill were confined for seven hours, during which three hours of optical imaging were obtained and no subsequent ill effects observed. The trap enabled two imaging methods to be employed: optical coherence tomography (OCT) and microscopy. OCT enabled internal structure and tissues to be imaged to a depth of approximately 2 mm and resolution of approximately 12 ...

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    5. Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

      Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

      Microscale quantification of cilia-driven fluid flow is an emerging area in medical physiology, including pulmonary and central nervous system physiology. Cilia-driven fluid flow is most completely described by a three-dimensional, three-component (3D3C) vector field. Here, we generate 3D3C velocimetry measurements by synthesizing higher dimensional data from lower dimensional measurements obtained using two separate optical coherence tomography (OCT)-based approaches: digital particle image velocimetry (DPIV) and dynamic light scattering (DLS)-OCT. Building on previous work, we first demonstrate directional DLS-OCT for 1D2C velocimetry measurements in the sub-1 mm/s regime (sub-2.5 inch/minute regime) of cilia-driven fluid flow in Xenopus ...

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    6. Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

      Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

      Purpose: To discriminate between subclinical fellow eyes of patients with keratoconus (scKCE) and normal eyes (NE) using swept-source Fourier-domain anterior segment optical coherence tomography (SS-OCT). Setting: University Medical Center Hamburg-Eppendorf, Germany. Design: Retrospective cross-sectional study. Methods: NE (both eyes with a KISA% Index <60; N = 213) and scKCE (KISA% Index <60, but an index of >100 in the fellow eye; N = 61) eyes were grouped according to the KISA% Index. Topography and tomography data were obtained by SS-OCT (Casia SS1000) and reviewed retrospectively. Receiver operating characteristics were performed for Casia SS1000 integrated automated parameters and newly computed indices. Additionally, discriminant ...

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    7. Enamel Quality after Debonding: Evaluation by Optical Coherence Tomography

      Enamel Quality after Debonding: Evaluation by Optical Coherence Tomography

      The aims of this study were to evaluate quantitatively the enamel fractures, adhesive remnants and bracket fragments on enamel after debonding of metal and ceramic brackets, and to quantify the layer of adhesive remnants in depth after two different cleanup procedures. Metal and ceramic brackets were bonded on 120 human incisors and then debonded using two different techniques with Side Cutter (SC) and Anterior Bracket Removal plier (ABR). After this, a high-speed tungsten carbide finishing bur or a low-speed tungsten carbide finishing bur was used. The debonded samples were submitted to enamel assessment with optical coherence tomography (OCT). In sequence ...

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    8. Real-Time Optical Coherence Tomography Segmentation?

      Real-Time Optical Coherence Tomography Segmentation?

      The recent publication, “Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region” by Tian et al. [1] raises the obvious question of what actually constitutes “real-time” processing? More broadly speaking, the paper reports on some segmentation results of OCT volumes acquired at the macula. The method used is based on graph traversal techniques that, when applied to image segmentation, allow the developer to very easily define boundaries from one side of an image to another in terms of their lowest cost traversal. For this traversal path to make sense, the input image data is first transformed ...

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    9. Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line

      Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line

      Optical coherence tomography (OCT) with advantages of high resolution and high sensitivity is an emerging optical imaging technology that performs cross-sectional tomographic imaging of microstructure in biological system. In spite of the improvement of the longitudinal resolution by using low coherence light source, the dispersion effect aggravates with the increase of spectral bandwidth, which result in serious image blur and loss of image features. We demonstrate a double-path rapid scanning optical delay line (D-RSOD) structure in reference arm that produce the additional phase delay and group delay independent in OCT. The phase delay determined by grating defocus offset (GDO) of ...

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    10. Application of fractional flow reserve and optical coherence tomography examinations in a patient presenting with recurrent angina: a case report

      Application of fractional flow reserve and optical coherence tomography examinations in a patient presenting with recurrent angina: a case report

      Introduction We present the different roles of fractional flow reserve and optical coherence tomography in guiding treatment in a patient with recurrent chest pain. Case presentation A 66-year-old Chinese woman presented to our department for the third time for her recurrent chest pain. Her physical examination was unremarkable; her previous two angiography examinations indicated that there was a stenosis of 50 to 70% in her proximal left anterior descending coronary artery. Optimal medical therapy was applied, but her symptoms did not disappear. Coronary angiography was conducted again after admission, accompanied by fractional flow reserve and optical coherence tomography. A lesion ...

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    11. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the CLN3 gene. Conclusion: In these rare cases of juvenile neuronal ceroid lipofuscinosis, optical coherence tomography enabled unambiguous detection of prominent morphologic abnormalities of the retina at the patient's first ...

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    12. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY

      Purpose: To describe the optical coherence tomography angiography features of diabetic retinopathy. Methods: Using a 70 kHz optical coherence tomography and the split-spectrum amplitude decorrelation angiography algorithm, 6 mm x 6 mm 3-dimensional angiograms of the macula of 4 patients with diabetic retinopathy were obtained and compared with fluorescein angiography for features cataloged by the Early Treatment of Diabetic Retinopathy Study. Results: Optical coherence tomography angiography detected enlargement and distortion of the foveal avascular zone, retinal capillary dropout, and pruning of arteriolar branches. Areas of capillary loss obscured by fluorescein leakage on fluorescein angiography were more clearly defined on optical ...

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    13. Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study

      Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study

      Purpose : To evaluate macular thickness (MT) changes, using spectral domain optical coherence tomography (SD-OCT) in patients with optic disc pit (ODP) maculopathy after pars plana vitrectomy (PPV) with or without internal limiting membrane (ILM) peeling. Procedures : Our retrospective study included nine patients with ODP maculopathy, treated with either PPV ( n  = 5) or PPV with ILM peeling ( n  = 4). All participants, who had a mean long-term follow-up of 33.4 ± 7.0 months, underwent a complete ophthalmological examination and SD-OCT. Due to the preoperative macular elevation, the postoperative MT in the operated patients was compared with that of fellow eyes and ...

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    14. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography

      Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography

      Oxygen supplementation [hyperoxia, increased fraction of inspired oxygen ( FiO 2 )] is an indispensable treatment in the intensive care unit for patients in respiratory failure. Like other treatments or drugs, hyperoxia has a risk-benefit profile that guides its clinical use. While hyperoxia is known to damage respiratory epithelium, it is unknown if damage can result in impaired capacity to generate cilia-driven fluid flow. Here, we demonstrate that quantifying cilia-driven fluid flow velocities in the sub - 100   μ m / s regime (sub-0.25 in./min regime) reveals hyperoxia-mediated damage to the capacity of ciliated respiratory mucosa to generate directional flow. Flow quantification was ...

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    3D optical phase reconstruction within PMMA samples using a spectral OCT system Two-grating Talbot bands spectral-domain interferometer Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography First Annual OCT Angiography Summit Signals a New Era in Imaging Technology Swept-Source OCT: Patent License Agreement between Massachusetts General Hospital and Heidelberg Engineering Optical identification based on time domain optical coherence tomography Degree of polarization (uniformity) and depolarization index: unambiguous depolarization contrast for optical coherence tomography OCT Medical Imaging Inc. Receives fast-track SBIR funding for “Clinical evaluation and development of a diagnostic multi-modal intravascular imaging system Post Doctoral Opening In Novel Optical Microscopy Technologies for Neuroscience Applications at Northwestern University Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses Observation of white spot lesions using swept source optical coherence tomography (SS-OCT): in vitro and in vivo study Experimental investigation of intravascular OCT for imaging of intracranial aneurysms
  7. Recent Quotes

    1. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      By Stephen A. Boppart
    2. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      By Stephen A. Boppart
    3. Based on this pivotal research, we believe that VivoSight scans should become the gold standard for non-invasive diagnosis and monitoring of non-melanoma skin cancer...We are now expanding the availability of our new generation VivoSight scanner in Germany and select territories in Europe.
      By Andy Hill
    4. We are delighted to join Leica Microsystems. Together, we believe we can jointly leverage our ophthalmic imaging technologies, address broader research and clinical markets, and more efficiently complete the next steps in integrating OCT imaging capabilities into the operating room.
      By Eric L. Buckland
    5. These acute results from the VISION study have exceeded even my high expectations going into the trial...Never before have we been able to see the arterial wall during atherectomy, nor have I seen these types of results, with this much control over the procedure outcomes and so little adjunctive therapy required to achieve the desired angiographic results, with only 4% of lesions treated receiving placement of a stent. Based on the data we have seen to date, I believe we continue to be on track to meet or exceed our primary safety endpoint once all six-month follow-up data becomes available.
      By John B. Simpson
    6. The ophthalmic optical coherence tomography (OCT) application was one of the key drivers.
      By John Roush
    7. Why it's a big deal is that OCT is the most commonly ordered test in ophthalmology.
      By David Wilson
    8. What's new is ability to use the OCT device to create an angiogram that actually is better than the one you get from injecting the dye.
      By David Wilson
    9. This is a tremendously exciting approach to granting that fosters the innovative thinking and scientific collaboration that are critical for the future of breast cancer research.
      By Judith A. Salerno
    10. OSA is greatly honored to recognize these leaders in the field of optics.
      By Elizabeth Rogan