1. Featured Articles

    1. Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing

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      Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing

      Perimeter Medical Imaging, Inc., the leader in real-time tissue imaging in the operating suite is pleased to announce the completion of a pre-public financing round raising $C4.4million. Perimeter intends to go public via a reverse takeover (RTO) with New World Resources (NW) in Q4 of this year. Funds raised in this pre-public round and anticipated RTO will support the commercialization of Perimeter's U.S. Food and Drug Administration (FDA) cleared OTISTM medical imaging technology. OTISTM is deployed in the surgical suite, empowering surgeons with real-time tissue imaging to help optimize cancer surgery outcomes. "We are pleased to have ...

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      Mentions: Perimeter Medical Imaging

    2. Culprit lesion morphology in young patients with st-segment elevated myocardial infarction: A clinical, angiographic and optical coherence tomography study

      Explore atherosclerosis-journal.com Cardiology
      Culprit lesion morphology in young patients with st-segment elevated myocardial infarction: A clinical, angiographic and optical coherence tomography study

      Background and aims About 20% of patients with ST-segment elevated myocardial infarction (STEMI) are young adults. Morphological characteristics of culprit lesion in young STEMI patients have not been systematically evaluated in vivo . The present study aimed to investigate culprit lesion characteristics in young patients versus older patients using optical coherence tomography (OCT). Methods 1442 STEMI patients who underwent OCT examination of culprit lesion were included and divided into young group (age ≤50 years, n = 400) and older group (age >50 years, n = 1042). Clinical characteristics, angiography and OCT findings were compared between the two groups. Results Culprit lesions in STEMI ...

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      Mentions: Harbin Medical University Jingbo Hou Bo Yu

    3. Optical coherence refraction tomography

      Explore Nature Publishing Group
      Optical coherence refraction tomography

      Optical coherence tomography (OCT) is a cross-sectional, micrometre-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and therefore tend to have better axial than lateral resolution. Such anisotropic resolution can obscure fine ultrastructural features. Furthermore, conventional OCT suffers from refraction-induced image distortions. Here, we introduce optical coherence refraction tomography (OCRT), which extends the superior axial resolution to the lateral dimension, synthesizing undistorted cross-sectional image reconstructions from multiple conventional images acquired with angular diversity. In correcting refraction-induced distortions to register the OCT images, OCRT also achieves spatially ...

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      Mentions: Joseph A. Izatt Duke University Sina Farsiu

    4. Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory

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      Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory

      Immediate opening at Duke University Biomedical Engineering Department for a postdoc interested in interdisciplinary applications of image analysis and computer vision with emphasis on optical coherence tomography image analysis. Postdoc will be supervised by Prof. Sina Farsiu ( http://people.duke.edu/~sf59/ ). The candidate must have a demonstrated strong background in image processing as evidenced by publication of papers in high-impact peer-reviewed journals. Programming skill in MATLAB/Python is required. PhD in EE, BME, or CS. Prior experience in ophthalmic sciences, optical coherence tomography, adaptive optics is a plus but not necessary. Projects can be chosen based on the interests ...

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      Mentions: Duke University Sina Farsiu

    5. Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

      Explore Science Translational Medicine Pulmonology
      Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

      Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although impairment of mucociliary clearance contributes to severe morbidity and mortality in people with CF, a clear understanding of the pathophysiology is lacking. This is, in part, due to the absence of clinical imaging techniques capable of capturing CFTR-dependent functional metrics at the cellular level. Here, we report the clinical translation of a 1-μm resolution micro-optical coherence tomography (μOCT) technology to quantitatively characterize the functional microanatomy of human upper airways. Using a minimally invasive intranasal imaging approach, we performed a clinical ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital University of Alabama

    6. High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band

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      High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band

      We present three-dimensional (3-D) high-resolution spectral-domain optical coherence microscopy (SD-OCM) by using a supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at half-maximum) in the 1700-nm spectral band. By using low-coherence interferometry with SC light and a confocal detection scheme, we realized lateral and axial resolutions of 3.4 and 3.8  μm in tissue ( n   =  1.38), respectively. This is, to the best of our knowledge, the highest 3-D spatial resolution reported among those of Fourier-domain optical coherence imaging techniques in the 1700-nm spectral band. In our SD-OCM, to enhance the imaging depth, a full-range method was ...

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      Mentions: Nagoya University Norihiko Nishizawa

    7. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Explore OSA | OSA Publishing
      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive optics—in particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected apertures, we improved aberration correction. Since these modifications only slightly increase the run time of the correction, we believe this method can become the algorithm of choice for many ...

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      Mentions: Gereon Hüttmann University of Lübeck Hendrik Spahr
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  2. Recent Articles From Around The Web

    1. The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis)

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      The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis)

      Efforts to reduce the size and costs of optical coherence tomography systems (OCT) for consumer applications, in general, focus on Fourier-domain OCT, due to its potential to be integrated on an optical chip, implementing the interferometer and the spectrometer together as a compact system. An alternative and near-term solution is multiple reference OCT. This technique utilizes a partial mirror in the reference arm to enhance the axial imaging depth of traditional time-domain OCT. The motivation of this thesis is to investigate the performance and sensitivity characteristics of multiple reference OCT in comparison to time-domain OCT. Due to the partial mirror ...

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      Mentions: National University of Ireland, Galway

    2. Calibration-free time-stretch optical coherence tomography with large imaging depth

      Explore OSA | OSA Publishing
      Calibration-free time-stretch optical coherence tomography with large imaging depth

      We demonstrate a calibration-free time-stretch optical coherence tomography (TS-OCT), based on an optical higher order dispersion compensation scheme, which substitutes the digital calibration with optical dispersion compensation. As a result, the acquired raw data can directly perform the Fourier transform, and data processing time is greatly reduced by 82%, compared with the digital calibration. Moreover, because of the high-sensitivity and calibration-free characteristics, the high-order dispersion compensation-based TS-OCT can increase sensitivity roll-off by 2.6 times to 6.91 mm/dB and effective imaging depth by 14.2% to 16 mm. The in vivo biological tissue imaging has been demonstrated, with ...

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    3. Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?

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      Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?

      Purpose: This study assesses the frequency of projection artifacts in optical coherence tomography angiography (OCTA) en face images and compares images before and after applying a 3-dimensional projection artifact removal (3D-PAR) algorithm. Methods: This is a single-center, retrospective study that included consecutive patients with any underlying diagnosis who had OCTA obtained from January to March 2017. Patients with various retinal diseases and also healthy eyes were included. All participants underwent imaging with a scan area of 3 mm × 3 mm. The 4 default en face slabs were analyzed: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR), and ...

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      Mentions: University of Toronto Mount Sinai School of Medicine

    4. Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Explore Wiley Online Library Ophthalmology
      Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Purpose To image retinal blood vessels in patients with Waldenström's macroglobulinemia using optical coherence tomography (OCT). Methods Retrospective case series examining fundus photographs and OCT scans of 16 eyes in eight patients with Waldenström's macroglobulinemia. Analyses included intravascular OCT reflectivity profiles and vessel diameters, and their relation to total immunoglobulin M (IgM) levels. Results In six out of eight patients, cross‐sectional OCT scans of larger retinal vessels (diameter > 100 μm) showed normal intravascular reflectivity and retrovascular shadowing. In two patients with the highest total IgM > 60 g/l, altered intravascular reflectivity, distinct anterior and posterior ...

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    5. Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

      Explore BIR Publications
      Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

      OBJECTIVES: Optical coherence tomography (OCT) is a non-invasive technique based on optical imaging with a micrometre resolution. The purpose of this study is to investigate the potential role of OCT in evaluating oral mucosa bullous diseases. METHODS: two patients with bullous pemphigoid (BP) and one patient with pemphigus vulgaris (PV) were examined and images of their oral lesions were performed using OCT. RESULTS: In OCT images, the BP blister has a clearly different morphology from the PV one compared to the blistering level. CONCLUSION: This exploratory study suggests that the OCT is able to distinguish epithelial and subepithelial layer in ...

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    6. The use of anterior segment optical coherence tomography (ASOCT) in demonstrating recurrence of vitreoretinal lymphoma (VRL) in the anterior vitreous

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      The use of anterior segment optical coherence tomography (ASOCT) in demonstrating recurrence of vitreoretinal lymphoma (VRL) in the anterior vitreous

      Background Primary vitreoretinal lymphoma (VRL) is a rare disease with 30–380 new cases in the United States per year. Its insidious process and spread to the central nervous system (CNS) leads to a mean 5-year survival rate from 41.4 to 71%. Medical treatment of VRL has been summarized extensively in the literature and involves intraocular rituximab and methotrexate as first line agents in unilateral VRL, with systemic chemotherapy to be considered in bilateral or CNS-involving disease. In addition, therapeutic “debulking” vitrectomy has been reported in the literature, with some limited success. Despite this, recurrence rate is high and ...

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    7. PHD POSITION – OPTICAL COHERENCE TOMOGRAPHY ON AGRO-FOOD PRODUCTS

      Explore Optical Coherence Tomography News Other Non-Medical , Jobs & Studentships
      PHD POSITION – OPTICAL COHERENCE TOMOGRAPHY ON AGRO-FOOD PRODUCTS

      (ref. BAP-2019-576) The MeBioS group performs groundbreaking research on innovative sensor technologies and the associated data analysis methods to understand and control the quality of products and ongoing processes. The research on sensors mainly focusses on optical sensor systems (spectroscopy, hyperspectral imaging, thermography, smart cameras,…). While the data research involves the optimal design of experiments, chemometrics, process monitoring and control, as well as artificial intelligence and deep learning. OCT/OCM is a challenging new technique for non-destructive 3D imaging of biological tissues, without the need for sample preparation! Project Monitoring living tissues and organisms for an extended period of time ...

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      Mentions: K. U. Leuven

    8. Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      Explore Wiley Online Library Cardiology
      Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture held annually, bringing together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community. During the SCAI 2019 Scientific Sessions, relevant topics in interventional cardiology were identified with the goals of defining the state of the field, current challenges, and future directions. Topics were determined by nomination, and solidified through a voting process ultimately vetted by SCAI leadership and the industry relations committee. The 2019 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b ...

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    9. Optical coherence tomography angiography of foveal neovascularisation in proliferative diabetic retinopathy

      Explore casereports.bmj.com Ophthalmology
      Optical coherence tomography angiography of foveal neovascularisation in proliferative diabetic retinopathy

      A 52-year-old man, a known case of type 2 diabetes mellitus and hypertension, who presented to us with bilateral diminution of vision since 1 year. He was diagnosed as a case of bilateral proliferative diabetic retinopathy and hypertensive retinopathy. A non-invasive imaging modality, optical coherence tomography angiography (OCTA), detected foveal neovascularisation in a background of diffuse diabetic macular oedema which would have been obscured by other investigations like fluorescein angiography.

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      Mentions: L V Prasad Eye Institute

    11. Anterior Segment Optical Coherence Tomography Angiography in Patients Following Cultivated Oral Mucosal Epithelial Transplantation

      Explore American Journal of Ophthalmology Ophthalmology
      Anterior Segment Optical Coherence Tomography Angiography in Patients Following Cultivated Oral Mucosal Epithelial Transplantation

      Purpose To analyze corneal neovascularization using anterior segment optical coherence tomography angiography (AS-OCTA) in patients following cultivated oral mucosal epithelial sheet transplantation (COMET). Design Observational case series. Methods Nine eyes in 7 patients were analyzed. Four images of corneal quadrant were obtained by AS-OCTA from each patient during follow-up post-COMET in the Department of Ophthalmology at Osaka University Hospital. The depth of corneal neovascularization was evaluated using en face and B-scan images. Each quadrant image was classified as one of the following five types: stromal, predominantly stromal, epithelial, predominantly epithelial, or avascular. The image quality of slit-lamp photography and AS-OCTA ...

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    12. Repeatability of quantitative measurements of retinal layers with SD-OCT and agreement between vertical and horizontal scan protocols in healthy eyes

      Explore Journals | PLOS Ophthalmology
      Repeatability of quantitative measurements of retinal layers with SD-OCT and agreement between vertical and horizontal scan protocols in healthy eyes

      Purpose To evaluate the repeatability of the new spectral domain optical coherence tomography (HOCT-1F), and also to evaluate the agreement between vertical and horizontal scan protocols. In addition, we also evaluated the relation between the repeatability and age. Methods Three consecutive measurements of the inner limiting membrane–retinal pigment epithelium (ILM-RPE), inner limiting membrane–inner plexiform layer (ILM-IPL) from macular horizontal and vertical scans, and inner limiting membrane–retinal nerve fiber layer (ILM-RNFL) from optic disc horizontal scan. 159 subjects were included in the analysis. The within subject standard deviation (Sw) and the repeatability limits (R limit ) are used to ...

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    13. Time-domain optical coherence tomography system based on moving-optical-wedge interferometer

      Explore ScienceDirect
      Time-domain optical coherence tomography system based on moving-optical-wedge interferometer

      In this work we present a time-domain optical coherence tomography system based on moving-optical-wedge interferometer. This device has the advantage of suppressing motion artifact. The major problem with such a system is dispersion in the wedge material. We propose an algorithm for compensation of such dispersion. Moreover, we investigate the effect of dispersion in resolution. So, we introduced artificial high dispersion in the wedge material to clarify this effect. Resolution is improved from 10 µm to 5 µm. Thus we can consider dispersion is a bless in improving resolution.

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    15. Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large ...

      Explore jove.com
      Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large ...

      Microbial biofilms form complex architectures at interphases and develop into highly scale-dependent spatial patterns. Here, we introduce an experimental system (hard- and software) for the automated acquisition of 3D optical coherence tomography (OCT) datasets. This toolset allows the non-invasive and multi-scale characterization of biofilm morphogenesis in space and time.

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      16. See all articles
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    1. (1 articles) Topcon Medical Systems
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    Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing Culprit lesion morphology in young patients with st-segment elevated myocardial infarction: A clinical, angiographic and optical coherence tomography study Optical coherence refraction tomography Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography? Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

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    1. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
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    2. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
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    7. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
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