1. Featured Articles

    1. Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      Explore jstage.jst.go.jp Cardiology
      Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      I ntravascular optical coherence tomography (OCT) is a light-based imaging modality that enables detailed visualization of the intraluminal structures in coronary arteries. High-resolution (10–20μm) cross-sectional images are generated by measuring the echo time delay and intensity of light that is reflected or backscattered from the internal structures in tissues.1,2 OCT is clinically useful during percutaneous coronary intervention (PCI) to assess lesion severity, optimize stent implantation, and characterize atherosclerotic plaques, including the identification of thin-cap fibroatheroma (TCFA) and lipid-rich plaques, which are reportedly responsible for periprocedural complications. OCT can also be used to assess the mechanism for ...

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      Mentions: Toshiro Shinke

    2. Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

      Explore ScienceDirect Ophthalmology
      Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

      Abstract Purpose To compare the diagnostic performance of human gradings versus predictions provided by a machine-to-machine (M2M) deep learning (DL) algorithm trained to quantify retinal nerve fiber layer (RNFL) damage on fundus photographs. Design Evaluation of a machine learning algorithm. Methods A M2M DL algorithm trained with RNFL thickness parameters from spectral-domain optical coherence tomography was applied to a subset of 490 fundus photos of 490 eyes of 370 subjects graded by two glaucoma specialists for the probability of glaucomatous optical neuropathy (GON), and estimates of cup-to-disc (C/D) ratios. Spearman correlations with standard automated perimetry (SAP) global indices were ...

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      Mentions: Duke University Felipe A. Medeiros

    3. Deep learning-based automated detection of retinal diseases using optical coherence tomography images

      Explore OSA | OSA Publishing Ophthalmology
      Deep learning-based automated detection of retinal diseases using optical coherence tomography images

      Retinal disease classification is a significant problem in computer-aided diagnosis (CAD) for medical applications. This paper is focused on a 4-class classification problem to automatically detect choroidal neovascularization (CNV), diabetic macular edema (DME), DRUSEN, and NORMAL in optical coherence tomography (OCT) images. The proposed classification algorithm adopted an ensemble of four classification model instances to identify retinal OCT images, each of which was based on an improved residual neural network (ResNet50). The experiment followed a patient-level 10-fold cross-validation process, on development retinal OCT image dataset. The proposed approach achieved 0.973 (95% confidence interval [CI], 0.971–0.975) classification ...

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      Mentions: Florida International University

    4. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Explore IEEE Xplore Cardiology
      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between two adjoining OCT A-line datasets. By interpretation of the velocity field as measured around the zero phase shift, the flow direction at specific angles can be qualitatively estimated. Imaging experiments ...

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      Mentions: Robert A. Huber Gijs van Soest Anton F. W. van der Steen

    6. Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      Explore OSA | OSA Publishing
      Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      There exists an unmet need for an optical coherence tomography (OCT) delivery scheme that is simple, robust, and applicable to general surgical applications. To deliver the beam in a narrow form factor, optical borescopes present an attractive potential solution. We present a method for enabling endoscopic delivery of OCT using a handheld rigid borescope adapted to a low-cost OCT engine. The system reduces the distal profile of the scanner, enabling application of the system in otherwise hard-to-access regions. The clinical potential of this design is demonstrated through real-time quantification of articular cartilage thickness, a primary biomarker of joint health during ...

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      Mentions: Duke University Adam Wax

    7. Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging

      Explore Home - Springer Cardiology
      Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging

      The three-dimensional reconstruction of optical coherence tomography and optical frequency domain imaging (3D-OCT/OFDI) helps optimize bifurcation percutaneous coronary interventions (PCIs) with side branch (SB) dilatation by identifying the optimal rewiring position. 3D-OCT/OFDI’s diagnostic performance for assessing the rewiring position into a jailed SB is unknown. We retrospectively evaluated the diagnostic performances of a conventional (ver. 1.1) and a new (ver. 1.2) online 3D-OFDI reconstruction system based on an offline 3D reconstruction system’s performance. We analyzed 45 patients’ 52 OFDI pullbacks with main vessel stenting followed by rewiring into a jailed SB for coronary bifurcation ...

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      Mentions: Takayuki Okamura

    8. Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm

      Explore Optical Coherence Tomography News Other Business News , Tunable Sources
      Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm

      Thorlabs announced today that it has released next-generation versions of its MEMS-VCSEL Swept-Wavelength Laser Sources. The new SL10 series, centered at 1060 nm, complements the already well-established SL13 series at 1300 nm and is available with four different sweep rates ranging from 60 kHz to 400 kHz. Based on a patented microelectromechanical system (MEMS) tunable vertical cavity surface emitting laser (VCSEL), these light sources feature a record-breaking coherence length of over 100 mm and include an active power control that maintains constant output power over the lifetime of the laser. All drive electronics and trigger signals needed to seamlessly integrate ...

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      Mentions: Thorlabs

    9. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Explore European Respiratory Journal Pulmonology
      Excess mucus viscosity and airway dehydration impact COPD airway clearance

      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical coherence tomography. Mucus changes in primary human airway epithelial cells and ex vivo ferret airways were assessed by histology and particle tracking microrheology. Linear mixed models for repeated measures identified ...

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      Mentions: Guillermo J. Tearney Johns Hopkins University Massachusetts General Hospital

    11. Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography

      Explore Nature Publishing Group
      Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography

      The non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength range, we used a combination of zero-delay acquisition and focus tracking that ensures optimal system sensitivity at any depth inside the sample. Subsequently, we developed an analysis model to adequately ...

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      Mentions: University of Twente Nienke Bosschaart

    12. Does lining class-II cavities with flowable composite improve the interfacial adaptation?

      Explore Taylor & Francis Online Dentistry
      Does lining class-II cavities with flowable composite improve the interfacial adaptation?

      The objective of this study was to assess in-vitro interfacial cavity adaptation of different adhesive/composites systems in class-II restoration using SS-OCT and to confirm the findings with a confocal laser scanning microscope (CLSM). Standardized rectangular-shaped class-II cavities were prepared on 24 extracted human molar teeth, bonded with adhesive and lined with flowable composite. Cavities were further restored by bulk filling using packable composite. Specimens were divided into four groups ( n  = 7) according to restorative materials used; PrimeFil with Estelite Posterior composites (PF; Tokuyama Dental), Clearfil Tri-S Bond Plus with Majesty LV flowable and Majesty Posterior composites (TS; Kuraray Noritake ...

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      Mentions: University of Washington Alireza Sadr Junji Tagami

    13. Automatic fibroatheroma identification in intravascular optical coherence tomography volumes

      Explore Home - Springer Cardiology
      Automatic fibroatheroma identification in intravascular optical coherence tomography volumes

      Coronary heart disease is the most common type of heart disease that leads to heart attacks. The identification of vulnerable plaques, especially the thin-cap fibroatheroma (TCFA), is crucial to the diagnosis of coronary artery disease. Intravascular optical coherence tomography (IVOCT), an emerging imaging modality, has been proven to be useful for the identification of vulnerable plaques. In this work, we propose an approach to identify the volumes with fibroatheroma frames automatically. In the proposed method, we first detect the lumen using a graph-search based method from unfolded images. Then a region of interest starting from the lumen boundary is cropped ...

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      Mentions: National University of Singapore Wakayama Medical University Chinese Academy of Sciences

    14. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Explore LWW Online Otolaryngology
      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney

    15. Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      Explore Healio.com Ophthalmology
      Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      BACKGROUND AND OBJECTIVE: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease. PATIENTS AND METHODS: A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties. RESULTS: This study included 16 patients. Texture was heterogeneous in all eyes in the SC and VKH groups, and in four eyes (40%) in the APMPPE group. Most ...

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    16. Ph.D. positions in Optical Imaging and Vision Science at Indiana University Bloomington

      Explore Optical Coherence Tomography News Jobs & Studentships
      Ph.D. positions in Optical Imaging and Vision Science at Indiana University Bloomington

      Two Ph.D. positions are available in Dr. Tankam’s laboratory in the Frontiers of Optical Imaging and Biology at Indiana University School of Optometry. The group focuses on developing cutting-edge optical imaging systems, including high-resolution optical coherence tomography and fluorescence microscopy, to enable new investigations in the biomedical research field. The group uses a translational approach to study disease mechanisms; from the fundamental understanding of biological processes involved in normal and pathological conditions in animal models to the early diagnostic and monitoring of disease progression in human subjects. The laboratory is looking for highly motivated students from various background ...

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      Mentions: Indiana University

    17. Cardiovascular OCT Imaging (Textbook)

      Explore Home - Springer Cardiology , Textbooks
      Cardiovascular OCT Imaging (Textbook)

      This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    18. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      Explore OSA | OSA Publishing
      Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      We report the use of an electrically tunable lens (ETL) in a 1.3 μm spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral blood flow imaging of all cortical layers by stitching the OCTA images automatically captured at six focal depths. Capillary vasculature and axial blood flow velocity were revealed in distinctive cortical ...

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      Mentions: University of Washington Ruikang K. Wang

    19. Metasurface-based focus-tunable mirror

      Explore OSA | OSA Publishing Probes
      Metasurface-based focus-tunable mirror

      Varifocal mirrors, which have various applications in optical coherent tomography and three-dimensional displays, are traditionally based on the fluid pressure or mechanical pusher to deform the mirror. The limitations of conventional varifocal mirrors are obvious, such as the heavy size of the device and constraints of tunability, due to their mechanical pressure control elements. The reprogrammable metasurface, a new flat photonic device with multifunction in an ultrathin dimension, paves the way towards an ultrathin and lightweight mirror with precise phase profile. Here, an active reconfigurable metasurface is proposed to achieve the manipulation of the wavefront. The meta-atom in the metasurface ...

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    20. Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography”

      Explore Optical Coherence Tomography News Jobs & Studentships
      Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography”

      School of Physical Sciences Location: Canterbury Salary: £32,500 Grade: Marie Curie Post Type: Full Time Contract Type: Fixed Term - 36 Months Release Date: Thursday 10 October 2019 Closing Date: 23.59 hours GMT on Monday 30 December 2019 (unless otherwise stated) Reference: STM-074-19 We are recruiting for three PhD Studentships in the fields of Optics and Laser Physics, with emphasis on optical coherence tomography for a period of 36 months with a start date anytime between 1st February 2020 and 31 January 2021, within the Applied Optics Group, School of Physical Sciences. These are supported by the Marie Curie ...

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      Mentions: Université Pierre et Marie Curie University of Kent
    21. See all articles

  2. Recent Articles From Around The Web

    1. Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

      Explore Hindawi Publishing Corporation Ophthalmology
      Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

      Background . The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP). Methods . This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes. Heterogeneity was evaluated using the chi-squared test based on the values of and I 2 . Results . Seven studies were included in this meta-analysis. The vessel density values measured in the superficial ...

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    2. The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      Purpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 5–18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20 ...

      Read Full Article
      Mentions: Sun Yat-Sen University

    3. Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography

      Explore Home - Springer Ophthalmology
      Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography

      Purpose To evaluate the three-dimensional choroidal vascularity index (CVI) in the eyes with treatment-naïve acute central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS OCT). Methods In this prospective cross-sectional study, OCT and OCT angiography covered an area of 12 × 12 mm centered on the fovea. Three-dimensional CVI was defined as the ratio of the choroidal vascular luminal volume to the total choroidal volume. The location of pigment epithelial detachment (PED) and the area with abnormal perfusion at choriocapillary layer were compared with the distribution of the three-dimensional CVI. Results Thirty-two eyes with treatment-naïve acute CSC, 18 ...

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      Mentions: Chinese Academy of Sciences

    4. Optical coherence tomography angiography assessment of retinal microvascular changes in diabetic eyes in an urban safety-net hospital

      Explore ScienceDirect Ophthalmology
      Optical coherence tomography angiography assessment of retinal microvascular changes in diabetic eyes in an urban safety-net hospital

      PURPOSE To determine whether quantitative optical coherence tomography angiography (OCTA) parameters can be used to distinguish among eyes at various stages of diabetic retinopathy (DR) in an urban safety-net hospital population. DESIGN Prospective cross-sectional study PARTICIPANTS 329 eyes from 329 patients were included in this study; 90 nondiabetic patients, 170 diabetic patients without retinopathy, 57 diabetes with mild to moderate NPDR, and 12 diabetes with severe NPDR to PDR. METHODS Patients underwent OCTA imaging and ultra-widefield fundus photography at Zuckerberg San Francisco General Hospital and Trauma Center between April and October 2018. For participants with diabetes, imaging was classified according ...

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      Mentions: UCSF

    5. Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Explore TVST Journal Ophthalmology
      Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Purpose : To analyze imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in diabetic retinopathy (DR). Methods : We conducted a prospective, observational study at Massachusetts Eye and Ear from December 2018 to March 2019. Proliferative diabetic retinopathy (PDR), nonproliferative diabetic retinopathy (NPDR), diabetic patients with no diabetic retinopathy (DR), and healthy control eyes were included. All patients were imaged with a SS-OCTA and the Montage Angio (15 × 9 mm) was used for analysis. Images were independently evaluated by two graders using the motion artifact score (MAS). All statistical analyses were performed using SPSS 25.0 and ...

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      Mentions: Harvard University Massachusetts Eye and Ear Infirmary

    6. Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model

      Explore OSA | OSA Publishing Neurology
      Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model

      The optical attenuation coefficient (OAC) estimated using optical coherence tomography (OAC-OCT) offers a label-free 3D mapping of tissue infarction, but the physiological origin of the OAC contrast remains unclear. For effectively suppressing OAC fluctuations, we propose a hybrid (wavelength/angle) division multiplexing (HDM) method, which improved the OAC contrast by 70.7% in tissue phantoms. To test the feasibility of OAC-based infarction detection, triphenyltetrazolium chloride (TTC) staining was performed on fresh ex vivo brain slices, and the TTC-defined infarction was used as the ground truth. Sharp OAC contrast was observed between the TTC-defined infarction (1.09 mm −1 ) and normal ...

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      Mentions: Zhejiang University Peng Li

    7. Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imagingv

      Explore Wiley Online Library Neurology
      Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imagingv

      Optical coherence tomography can differentiate brain regions with intrinsic contrast and at a micron scale resolution. Such a device can be particularly useful as a realtime neurosurgical guidance tool. We present, to our knowledge, the first full‐field swept‐source optical coherence tomography system operating near a wavelength of 1310 nm. The proof‐of‐concept system was integrated with an endoscopic probe tip, that is compatible with deep brain stimulation keyhole neurosurgery. Neuroimaging experiments were performed on ex vivo brain tissues and in vivo in rat brains. Using classification algorithms involving texture features and optical attenuation, images were successfully classified ...

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      Mentions: University of Toronto

    8. Etching-enabled extreme miniaturization of graded-index fiber-based optical coherence tomography probes

      Explore SPIE Digital Library Probes
      Etching-enabled extreme miniaturization of graded-index fiber-based optical coherence tomography probes

      We introduced and validated a method to miniaturize graded-index (GRIN) fiber-based optical coherence tomography (OCT) probes down to 70  μm in diameter. The probes consist in an assembly of single-mode (SM), coreless (CL), and graded-index (GRIN) fibers. We opted for a probe design enabling controlled size reduction by hydrogen fluoride etching. The fabrication approach prevents nonuniform etching for both the GRIN and SM fiber components, while it requires no probe polishing postetching. We found that the miniaturized probes present insignificant loss of sensitivity (∼1  dB) compared to their thicker (125  μm) counterparts. We also showed that their focusing capabilities remain ...

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      Mentions: University of Montreal University of British Columbia

    9. Repeatability of Optical Coherence Tomography Angiography in Uveitic Eyes

      Explore TVST Journal Ophthalmology
      Repeatability of Optical Coherence Tomography Angiography in Uveitic Eyes

      Purpose : To investigate the intravisit repeatability of optical coherence tomography angiography (OCTA) in a cohort of uveitis patients. Methods : One hundred ten patients were imaged twice per eye, per visit, using the Zeiss Cirrus HD-OCT Model 5000 device. To calculate choriocapillaris flow void area (CC FV) 6 × 6-mm images were used, and 3 × 3-mm images were used to calculate vessel density (VD) and the foveal avascular zone area (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Repeatability was measured using Bland-Altman analyses and intraclass correlation coefficients (ICC) with associated coefficient of variation (CV). Results : The level ...

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      Mentions: National Institutes of Health

    11. Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers

      Explore uspto.gov Patents
      Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers

      This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers (SOAs) can be configured to maintain a respective polarization state in an optical input signal provided from a light source (e.g., a broadband light source). The different polarization states can be combined by an optical combiner (e.g., a polarization maintaining fiber coupler) and provided to drive a reference arm and a sample arm implemented in an OCT system.

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      Mentions: Andrew M. Rollins Case Western Reserve University Hui Wang

    12. Apparatus and method for generating 3-D data for an anatomical target using optical fiber shape sensing

      Explore uspto.gov Patents , Probes
      Apparatus and method for generating 3-D data for an anatomical target using optical fiber shape sensing

      A fiber housing includes multiple shape sensing cores and a single optical core. A distal end of the fiber housing is positionable to direct the single optical core to a current point of an anatomical target. Collimated light over a first range of frequencies is projected from the single optical core to the current point. OFDR is used to detect reflected light scattered from the current point and to process the detected light to determine a distance to the current point. Light over a second range of frequencies is projected through the multiple shape sensing optical cores to the distal ...

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    13. Speckle reduction in optical coherence tomography images

      Explore uspto.gov Patents
      Speckle reduction in optical coherence tomography images

      An optical coherence tomography (OCT) image composed of a plurality of A-scans of a structure is analyzed by defining, for each A-scan, a set of neighboring A-scans surrounding the A-slices scan. Following an optional de-noising step, the neighboring A-scans are aligned in the imaging direction, then a matrix X is formed from the aligned A-scans, and matrix completion is performed to obtain a reduced speckle noise image.

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      Mentions: Topcon Medical Systems

    14. Absolute linear-in-k spectrometer designs enabled by freeform optics

      Explore OSA | OSA Publishing
      Absolute linear-in-k spectrometer designs enabled by freeform optics

      Linear-in-wavenumber, k , spectrometers have the merits of saving signal processing time and improving the sensitivity of spectral-domain optical coherence tomography (SD-OCT) by avoiding post- k -interpolation. We report on an approach leveraging freeform optics to linearize spectrometers in k to achieve an extremely low residual k -nonlinearity in design. A freeform lens reduced the k -nonlinearity from 2.47% for a benchmark spectrometer to 2.79 × 10 −5 % and 3.36 × 10 −9 % using the Fringe Zernike coefficients up to the 16 th term and 37 th term, respectively. A simulation model was developed to evaluate the performance of SD-OCT ...

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      Mentions: University of Rochester Jannick P. Rolland

    15. Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa

      Explore Home - Springer Ophthalmology
      Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa

      Purpose To investigate the association of retinal biomarkers with the choroidal parameters in retinitis pigmentosa (RP). Methods This prospective study included 69 eyes of 36 patients with RP. Choroidal vascularity index (CVI) was defined as the ratio of luminal area to stromal area after binarization on EDI–OCT images. Choroidal thickness (CT); peripapillary CT, the disruptions of the ellipsoid zone (EZ) and external limiting membrane (ELM); and the existence of disorganization of the retinal inner layers (DRIL) and epiretinal membrane (ERM) in central 1000 μm were noted. Results Having DRIL and the disruption of EZ and ELM was significantly associated ...

      Read Full Article
      16. See all articles
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  9. Picture Gallery

    Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ― Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs Deep learning-based automated detection of retinal diseases using optical coherence tomography images Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography Robot prototype shows promise for microsurgery on eyes and aneurysms Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm Excess mucus viscosity and airway dehydration impact COPD airway clearance Optovue's 10-Part Video Series on Ophthalmic OCT Interpretation. Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography Does lining class-II cavities with flowable composite improve the interfacial adaptation?

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    1. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    2. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    3. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    4. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    5. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    6. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    7. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    8. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    9. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    10. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney