1. Recent Articles From Around The Web

    1. Optical coherence tomography imaging in keratoconus

      Optical coherence tomography imaging in keratoconus

      Invited Review: Optical coherence tomography (OCT) is being increasingly used as a tool in the diagnosis and management of keratoconus. While elevation‐based topography remains essential, there is an expanding role for cross‐sectional OCT imaging in the diagnosis of the disease. Images and measurements of corneal thickness, and in particular, epithelial thickness, may be important in diagnosing early cases, and following procedures such as intrastromal corneal ring segments, corneal transplants and corneal collagen cross‐linking.

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    2. Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Objective: To evaluate the use of nanosilver fluoride in the enamel remineralization process through optical coherence tomography . Material and Methods: All samples were submitted to demineralization process by pH cycling during 14 days and randomly distributed into three groups (n = 11): Nanosilver Fluoride (NSF), Sodium fluoride (NaF), and negative control. Optical coherence tomography images were acquired at three different moments: initial stage (T0), post caries formation (T1), and post pH cycling (T2). The integrity of the enamel surface and the measurement of the volume loss for the tissue after pH cycling in comparison to initial images were obtained from optical ...

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    3. Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      BACKGROUND AND OBJECTIVE: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH). PATIENTS AND METHODS: A case series of eight patients diagnosed with IRAH. RESULTS: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions. Fundus autofluorescence (FAF) changes were seen in all eight cases. Ocular ultrasound was able to identify a lesion in only five of the seven cases. Optical coherence tomography ...

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    4. Choroidal Vascularity Index Using Swept-Source and Spectral-Domain Optical Coherence Tomography: A Comparative Study

      Choroidal Vascularity Index Using Swept-Source and Spectral-Domain Optical Coherence Tomography: A Comparative Study

      BACKGROUND AND OBJECTIVE: Choroidal vascularity index (CVI) is a noninvasive tool to assess choroidal structure. The objective of the current study was to compare the CVI measurements on swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) scans using the same image binarization protocol. PATIENTS AND METHODS: This prospective study was conducted from July 2016 through January 2017 and involved 54 healthy volunteers at a tertiary referral eye care institute in Southern India. Choroidal scans were obtained using both SS- and SD-OCT machines. An automated binarization algorithm was used to compute CVI. RESULTS: The mean CVI with SS-OCT scans was ...

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    5. Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD‐OCT)

      Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD‐OCT)

      Purpose The purpose of this case series is to evaluate the use of spectral domain optical coherence tomography (SD‐OCT) imaging in equine corneal disease to demonstrate the feasibility, diagnostic effectiveness, and limitations of this imaging modality. Methods Retrospective study: Handheld SD‐OCT (Envisu, Bioptigen Inc, Morrisville, NC) was used for high‐resolution imaging of horses with corneal disease presenting to the North Carolina State University Equine Ophthalmology Service from 2013 to 2018. Results Fourteen horses were included in this study, including six horses with corneal ulceration, three with stromal abscesses (SA), three with immune‐mediated keratitis (IMMK), and two ...

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      Mentions: Bioptigen
    6. Attention to Lesion: Lesion-Aware Convolutional Neural Network for Retinal Optical Coherence Tomography Image Classification

      Attention to Lesion: Lesion-Aware Convolutional Neural Network for Retinal Optical Coherence Tomography Image Classification

      Automatic and accurate classification of retinal optical coherence tomography (OCT) images is essential to assist ophthalmologist in the diagnosis and grading of macular diseases. Clinically, ophthalmologists usually diagnose macular diseases according to the structures of macular lesions, whose morphologies, size, and numbers are important criteria. In this paper, we propose a novel lesion-aware convolutional neural network (LACNN) method for retinal OCT image classification, in which retinal lesions within OCT images are utilized to guide the CNN to achieve more accurate classification. The LACNN simulates the ophthalmologists’ diagnosis that focuses on local lesion-related regions when analyzing the OCT image. Specifically, we ...

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    7. Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment

      Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment

      Objective To use optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in assessing myocardial bridging (MB) vessel size and wall thickness. Background During stent implantation, MB is associated with complications, especially perforation. Methods OCT and IVUS were performed in 56 patients with typical angiographic “milking” from November 2016 to May 2017. The vessel area and thickness in the MB segments and adjacent proximal and distal reference segments were measured and compared with eight normal left anterior descending (LAD) segment (no atherosclerosis in a segment that was at least 20 mm long and that began ~40 mm distal to the LAD ...

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    8. Telecentric broadband objective lenses for optical coherence tomography

      Telecentric broadband objective lenses for optical coherence tomography

      Freeform optical components enable significant advances for optical systems. A major challenge for freeform optics is the current lack of metrology methods with measurement uncertainty on the order of tens of nanometers or less. Towards addressing this challenge, optical coherence tomography (OCT) is a viable technique. In the context of low uncertainty metrology, the design requirements pertaining to the sample arm of an OCT metrology system are explicitly addressed in this paper. Two telecentric, broadband, diffraction limited, custom objective lens designs are presented with their design strategies. One objective lens was fabricated and experimentally tested for wavefront performance and telecentricity ...

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    9. (Cost)-Effectiveness of OCT in BCC (ROCTI)

      (Cost)-Effectiveness of OCT in BCC (ROCTI)

      Skin cancer incidence rises worldwide due to high sun exposure and ageing. Basal cell carcinoma (BCC) is the most prevalent form, with a lifetime risk of 16-20% in the Netherlands. Currently, the gold standard for diagnosing and subtyping basal cell carcinoma (BCC) is a punch biopsy. Since this technique is invasive, new non-invasive diagnostic methods have been developed, including optical coherence tomography (OCT). In patients with clinical and dermoscopic suspicion of BCC, OCT makes it possible to confirm and subtype BCC with high confidence, thereby obviating the need for a punch biopsy in a substantial part of patients. Hence, BCC ...

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    10. Precision analysis and optimization in phase decorrelation OCT velocimetry

      Precision analysis and optimization in phase decorrelation OCT velocimetry

      Quantitative flow velocimetry in Optical Coherence Tomography is used to determine both the axial and lateral flow component at the level of individual voxels. The lateral flow is determined by analyzing the statistical properties of reflected electro-magnetic fields for repeated measurements at (nearly) the same location. The precision or statistical fluctuation of the quantitative velocity estimation depends on the number of repeated measurements and the method to determine quantitative flow velocity. In this paper, both a method to determine quantitative flow velocity and a model for the prediction of the statistical fluctuations of velocity estimations are developed to analyze and ...

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    11. Image-guided vibrometry system integrated with spectral- and time-domain optical coherence tomography

      Image-guided vibrometry system integrated with spectral- and time-domain optical coherence tomography

      Vibrometry using optical coherence tomography (OCT) can provide valuable information for investigating either the mechanical properties or the physiological function of biological tissues, especially the hearing organs. Real-time imaging of the measured tissues provides structure imaging and spatial guidance for and is thus highly demanded by such vibrometry. However, the traditional time-domain OCT (TD-OCT) systems, although capable of subnanometric vibrometry at large ranges of frequencies, are unable to offer an imaging speed that is high enough to acquire depth-resolved images for guidance. The spectral-domain OCT (SD-OCT) systems, although allowing image-guided vibrometry, are challenged in measuring vibration at high frequencies, particularly ...

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    12. Faster, wider, deeper: imaging advances in focus at Hot Topics session

      Faster, wider, deeper: imaging advances in focus at Hot Topics session

      Continuing the theme, Yoshiaki Yasuno from the University of Tsukuba in Japan followed Xu with a talk on extending optical coherence tomography (OCT) toward multiple-contrast imaging. Yasuno notes that although several such extensions, like Doppler OCT, OCT angiography, and polarization-sensitive OCT, have been investigated for several years, image interpretation is often complicated, so the clinical value of the techniques has only been recognized recently. The Tsukuba group studies various forms of OCT and their applications in ophthalmology and dermatology. Work being presented at Photonics West 2019 included compression-based, polarization-sensitive optical coherence elastography (PS-OCE), developed for simultaneous analysis of bire¬fringence ...

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    1. Applications:

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  2. Organizations in the News

    1. (2 articles) UCLA
    2. (2 articles) National Institutes of Health
    3. (2 articles) University of Tsukuba
    4. (2 articles) Massachusetts General Hospital
    5. (2 articles) UC Davis
    6. (2 articles) Cornell University
    7. (2 articles) VU University Amsterdam
    8. (1 articles) Stanford University
    9. (1 articles) Harvard University
    10. (1 articles) Leiden University
  3. People in the News

    1. (2 articles) Yoshiaki Yasuno
    2. (1 articles) Vivek J. Srinivasan
    3. (1 articles) Guillermo J. Tearney
    4. (1 articles) Anita Mahadevan-Jansen
    5. (1 articles) Michalina J. Góra
    6. (1 articles) John S. Werner
    7. (1 articles) Yuhua Zhang
    8. (1 articles) Rox Anderson
    9. (1 articles) Jon Holmes
    10. (1 articles) Anderson S. L. Gomes
    11. (1 articles) Giovanni Gregori
    12. (1 articles) Norman S. Nishioka
    13. (1 articles) Philip J. Rosenfeld
    14. (1 articles) Ravi S. Jonnal
    15. (1 articles) Chia-Pin Liang
  4. OCT Companies in the News

    1. (2 articles) Optovue
    2. (2 articles) Carl Zeiss Meditec
    3. (2 articles) Bioptigen
    4. (1 articles) Movu
    5. (1 articles) Tomey Corporation
    6. (1 articles) Santec
    7. (1 articles) MedLumics
    8. (1 articles) Nidek
    9. (1 articles) Heidelberg Engineering
    10. (1 articles) Michelson Diagnostics
  5. Picture Gallery

    BiOS Hot Topics: Changing of the Guard Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients System Engineer Opening at Heidelberg Engineering in Lübeck Germany Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo SPECTRALIS OCT2 Module Improves Speed and Efficiency on the International Space Station Toward a multimodal fusion of layered cultural object images: complementarity of optical coherence tomography and terahertz time-domain imaging in the heritage field Optical coherence tomography imaging in keratoconus https://doi.org/10.1111/cxo.12880 Bacillary layer detachment: a novel optical coherence tomography finding as part of blunt eye trauma
  6. Recent Quotes

    1. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson
    2. Rox and I would like to take this opportunity to thank SPIE, program track chairs, conference chairs, and all of you in the com¬munity for the opportunity and the privilege to serve as co-chairs of BiOS all these years.
      By James G. Fujimoto
    3. Among the developments in the past 2 years, OCTA is by far the most important...Clinically, OCTA represents a paradigm change in angiography. It requires no dye injection, is faster (no waiting for dye transit), noninvasive, cheaper, and it can be used at every visit for screening and monitoring. OCTA will be used a lot more that fluorescein angiography ever was.
      By David Huang
    4. ATS9130 is a continuation of our effort to provide cost-effective yet powerful products to OEMs...ATS9130 provides data streaming, a feature that is usually absent in products in this price range.
      By Muneeb Khalid
    5. We see the power of OCT being utilized in several new areas, and appropriate software development tools are essential to speed up that progress. This software platform is a critical step in reaching our mission of OCT for all.
      By Nishant Mohan
    6. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      By Jay S. Duker
    7. The SBIR program democratizes funding for emerging companies, providing critical financial resources to regions of the country that may not have access to the venture capital of the major metropolitan areas.
      By Eric L. Buckland
    8. The VEGA series swept source OCT imaging systems have proven to be an excellent tool for a multitude of imaging applications. With this system series update, we aimed to increase the performance and ease of use for customers...The OCT applications team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    9. It’s an interesting time in this market...Level 4 and 5 autonomy needs a level of performance, range, resolution, frame rate, and immunity that legacy ToF sensors just can’t deliver. Couple that to cost goals that can only be met with a true all-semiconductor solution and you see the challenge. We have the huge advantage that we’ve been designing and manufacturing the core technology in this FMCW LiDAR sensor for more than 10 years.
      By Michael P. Minneman
    10. The initiation of our first U.S. based home OCT clinical trial is an important step towards bringing this leading-edge technology to eAMD patients, their caregivers, and the eye care community...Our collaboration with Wasatch Photonics will continue to be instrumental to our organization as the U.S. Food and Drug Administration (FDA) recently granted our Home Optical Coherence Tomography (OCT) System with ‘Breakthrough Device Designation’, a program designed to expedite patient access to novel technologies.
      By Susan Orr