1. Recent Articles From Around The Web

    1. Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study

      Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study

      Previous studies have reported a circadian variation in the onset of ST-segment elevation myocardial infarction (STEMI). However, underlying mechanisms for the circadian variation have not been fully elucidated. We investigated the relationship between onset of STEMI and the underlying pathology using optical coherence tomography (OCT). Patients with a diagnosis of STEMI were selected from a multicenter OCT registry. Patients were divided into 4 groups based on the estimated time of onset (00:00–05:59, 06:00–11:59, 12:00–17:59, or 18:00–23:59). Underlying pathologies of MI (plaque rupture, plaque erosion, and calcified plaque) were ...

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    2. Nonculprit Lesion Plaque Morphology in Patients With ST-Segment–Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography Substudys

      Nonculprit Lesion Plaque Morphology in Patients With ST-Segment–Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography Substudys

      Background: Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment–elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown. Methods: In a prospective substudy of the COMPLETEs trial (Complete vs Culprit-Only Revascularization to Treat Multi-Vessel Disease After Early PCI for STEMI), we performed optical coherence tomography of at least 2 coronary arteries before nonculprit lesion percutaneous coronary intervention in 93 patients with ST-segment–elevation myocardial infarction and multivessel disease; and the ST-segment–elevation myocardial infarction culprit vessel if there was unstented segment amenable to imaging ...

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    3. Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study

      Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study

      We evaluated the impact of diurnal variation on choroidal and retinal microvasculature and structural measurements using a swept-source optical coherence tomography angiography machine (SS-OCTA; PLEX Elite 9,000, Carl Zeiss Meditec, Inc., Dublin, USA). Fourteen participants who were without ocular diseases underwent SS-OCTA imaging using 3 × 3-mm 2 macular scan pattern on two separate days at five time points. Choriocapillaris flow voids were generated to determine its density (percentage), size (μm) and numbers. Perfusion densities of the large superficial vessels, as well as capillaries on superficial and deep vascular plexuses were generated from retinal angiograms. Subfoveal choroidal and retinal thicknesses ...

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    4. Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

      Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

      Purpose To investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage. Study design Retrospective cross-sectional study. Methods A total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses. Results Age ( P = 0.010) and signal strength ( P < 0.001) were associated with macular vessel density in healthy eyes. In glaucomatous eyes, age, signal strength, ganglion ...

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    5. Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging

      Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging

      Purpose : To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin–melanolipofuscin (LM), mitochondria, and nuclei. Methods : A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An aligned image stack was generated using serial block-face scanning electron microscopy and was annotated by expert readers (TrakEM, ImageJ). Acquired measures included cell body and nuclear volume ( n = 17); organelle count in apical processes ( n = 17) and cell bodies ( n = 8); distance of cell body organelles along a normalized apical–basal axis ( n = 8); and dimensions ...

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    6. Unique corneal tomography features of allergic eye disease identified by OCT imaging and artificial intelligence

      Unique corneal tomography features of allergic eye disease identified by OCT imaging and artificial intelligence

      The purpose of this study was to assess unique corneal tomographic parameters of allergic eye disease (AED) using optical coherence tomography (OCT) and artificial intelligence (AI). A total of 57 eyes diagnosed with AED were included. The curvature and aberrations of the air‐epithelium (A‐E) and epithelium‐Bowman's layer (E‐B) interfaces were calculated. Random forest AI models were built combing this data with the parameters of healthy, forme fruste keratoconus (FFKC) and KC eyes. The AI models were cross‐validated with 3‐fold random sampling. Each model was limited to 10 trees. The AI model incorporating both ...

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    7. Swept-source and multimodal OCT technologies offer clinical advantages

      Swept-source and multimodal OCT technologies offer clinical advantages

      Investing the time, money and resources in new technologies is vitally important, allowing earlier diagnosis, increasing patient confidence and ensuring that decisions are made based on the best data available. Contemporary optical coherence tomography (OCT) devices are providing clinicians with incredible visual data, reporting tools, and operational benefits. Although “trading up” comes with a considerable (and often intimidating) price tag, in my experience the clinical and business value inherent to these instruments justifies the expenditure. The modern OCT devices available today—whether those devices offer swept-source (SS) or spectral-domain (SD) imaging technology—are multimodal, meaning clinicians can capture an incredible ...

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    8. Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study

      Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study

      This study aimed to evaluate the early vascular response of ultra-thin strut bioresorbable polymer sirolimus-eluting stents (BP SES) using optical frequency domain imaging (OFDI). Ultra-thin strut BP SES have superior outcomes in terms of efficacy and safety endpoints when compared to other thin strut new-generation stents. However, the factors contributing to the superiority of BP SES over other thin strut new-generation stents are unclear. A total of 32 patients with multivessel disease requiring staged procedures at 1 month were enrolled from 3 cardiovascular institutions; of these, 31 were immediately assessed by OFDI ( n  = 31). All patients were assessed at 1 ...

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    9. OCT, OCTA show promise in screening for DR

      OCT, OCTA show promise in screening for DR

      As COVID-19 c h a nges practice operations, telehealth is on the rise as a viable option for patients who may not obtain in-person eye care. 1 Currently, video and telephone-based consultations are garnishing the most attention; however, telemedicine has been making waves in eye care for the past several years, particularly when it comes to the retina. Guided by the principles outlined by the Early Treatment Diabetic Retinopathy Study (ETDRS), an important function of primary eyec are is the grading of diabetic retinopathy (DR) to allow for the appropriate identification of patients with vision-threatening disease. 2 Recently, artificial intelligence ...

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    10. Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

      Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

      Fluorescence-guided surgery is a state-of-the-art approach for intraoperative imaging during neurosurgical removal of tumor tissue. While the visualization of high-grade gliomas is reliable, lower grade glioma often lack visible fluorescence signals. Here, we present a hybrid prototype combining visible light optical coherence microscopy (OCM) and high-resolution fluorescence imaging for assessment of brain tumor samples acquired by 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery. OCM provides high-resolution information of the inherent tissue scattering and absorption properties of tissue. We here explore quantitative attenuation coefficients derived from volumetric OCM intensity data and quantitative high-resolution 5-ALA fluorescence as potential biomarkers for tissue malignancy including otherwise ...

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    11. Thromboembolic or atherosclerotic? Optical coherence tomography in determining the cause of myocardial infarction with ST-segment elevation

      Thromboembolic or atherosclerotic? Optical coherence tomography in determining the cause of myocardial infarction with ST-segment elevation

      In the last years, due to its high image resolution, Optical Coherence Tomography (OCT) has been largely exploited in the assessment of atherosclerotic plaque features. The results obtained in the OCT imaging may determine the choice of optimal treatment technique [1,2]. A 55-year-old man with no history of any cardiovascular disease was admitted to the hospital with typical severe retrosternal pain. Acute myocardial infarction with ST-segment elevation (STEMI) was diagnosed. Immediate coronary angiography showed large thrombus causing subtotal occlusion in the medial and distal segments of the right coronary artery (RCA) with TIMI flow 2 and the occlusion of ...

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    12. Application of Artificial Intelligence in Targeting Retinal Diseases

      Application of Artificial Intelligence in Targeting Retinal Diseases

      Retinal diseases affect an increasing number of patients worldwide because of the aging population. Request for diagnostic imaging in ophthalmology is ramping up, while the number of specialists keeps shrinking. Cutting-edge technology embedding artificial intelligence (AI) algorithms is thus advocated to help ophthalmologists perform their clinical tasks as well as a source for novel biomarkers. In particular, optical coherence tomography (OCT) evaluation of the retina can be augmented by algorithms based on machine learning and deep learning to early detect, qualitatively localize and quantitatively measure epi/intra/subretinal abnormalities or pathological features of macular or neural diseases. In this paper ...

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    13. Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous

      Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous

      Purpose We describe a case of posterior capsule rupture during femtosecond laser-assisted cataract surgery (FLACS) due to direct exposure of the posterior capsule to the laser beam. Observations A 47-year-old man underwent FLACS for anterior capsule opacity. The CATALYS® system automatically detected the posterior capsule from the optical coherence tomography (OCT) images, after which the operator manually adjusted the line of posterior capsule. Femtosecond laser irradiation was presumed to be completed successfully. However, upon insertion of a phaco-tip, the diced nucleus of the lens dropped into the vitreous chamber. Reviewing intraoperative OCT images of the treatment summary to check the ...

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  2. Organizations in the News

    1. (7 articles) National Institutes of Health
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  3. People in the News

    1. (2 articles) Srinivas R. Sadda
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  4. OCT Companies in the News

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  5. Picture Gallery

    Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography A Method for the Assessment of Textile Pilling Tendency Using Optical Coherence Tomography Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning Frequency-doubled FDML-MOPA laser in the visible Post-doctoral Scholar Position in OCT Endoscopy at the University of North Carolina at Chapel Hill The analysis of prostate tissue by optical coherence tomography (Thesis) Sensorless adaptive-optics optical coherence tomographic angiography Wasatch Photonics adds 1600 nm OCT spectrometer for deep tissue imaging New Research Finds Abbott's Optical Coherence Tomography Imaging Changed Treatment Decisions in 88% of Artery Blockages Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study Assessing atherothrombotic burden with optical coherence tomography analysis may facilitate post‐PCI prognostication and antiplatelet therapy Nonculprit Lesion Plaque Morphology in Patients With ST-Segment–Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography Substudys
  6. Recent Quotes

    1. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    2. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    3. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    4. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    5. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    6. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    7. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    8. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen
    9. We hope that this new lab between SNEC-SERI and NTU will be the start of an important programme to utilise engineering solutions to help and improve care of our patients with eye problems.
      By Tin Aung
    10. “At PhotoniCare we set out to solve the massive problem of frequent misdiagnosis of middle ear infections, and the overuse of antibiotics and referrals to surgery in children that result...We thank the FDA for clearing our TOMi Scope under a new product code unique to our technology, and look forward to bringing this innovation to doctors and patients very soon.”
      By Ryan L. Shelton