1. Featured Articles

    1. Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      A postdoctoral research fellow position is available in the Center for Ophthalmic Optics & Lasers Lab ( www.coollab.net ), Casey Eye Institute, Oregon Health & Science University. This is an outstanding opportunity for a candidate to use optical coherence tomography to conduct visual optics research in an academic ophthalmology setting. The researcher on this position will work with a team of scientists, engineers and physicians to develop ultrahigh-performance OCT systems for comprehensive optical characterization of the anterior eye and wide-field ocular surface topography, to improve post-refractive surgery intraocular lens power calculation, therapeutic scleral lens design, diagnosis and classification of corneal shape irregularities ...

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      Mentions: National Institutes of Health David Huang Oregon Health & Science University

    2. Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Conavi Medical Inc. is pleased to announce that it has received a Health Canada Medical Device License for the Novasight Hybrid System. This patented technology is the only clinical system that enables simultaneous imaging of coronary arteries with both intravascular ultrasound (IVUS) and optical coherence tomography (OCT), and was invented at Sunnybrook Research Institute. Angioplasty and stenting is performed four million times around the world every year as an important part of the treatment of coronary artery disease, including patients suffering from heart attacks and angina. Recent randomized studies with existing IVUS systems have shown that intravascular imaging has the ...

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      Mentions: Sunnybrook Health Sciences Centre Brian K. Courtney Conavi Medical Inc.

    3. Finger-mounted quantitative micro-elastography

      Explore OSA | OSA Publishing Probes
      Finger-mounted quantitative micro-elastography

      We present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is rigidly affixed to a 3D-printed thimble that is mounted on the finger. Analogous to manual palpation, the probe compresses the tissue through the force exerted by the finger. The resulting ...

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      Mentions: University of Western Australia University of St. Andrews Andrea Curatolo

    4. Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms?

      Explore Duke Health Neurology , Ophthalmology
      Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms?

      A quick eye exam might one day allow eye doctors to check up on both your eyeglasses prescription and your brain health. A study of more than 200 people at the Duke Eye Center published March 11 in the journal Ophthalmology Retina suggests the loss of blood vessels in the retina could signal Alzheimer’s disease. In people with healthy brains, microscopic blood vessels form a dense web at the back of the eye inside the retina, as seen in 133 participants in a control group. In the eyes of 39 people with Alzheimer’s disease, that web was less ...

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      Mentions: National Institutes of Health Duke University

    5. Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Explore Ophthalmology Retina Neurology , Ophthalmology
      Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

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      Mentions: Duke University Carl Zeiss Meditec

    6. Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy

      Explore Nature Publishing Group
      Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy

      Cellular traction forces (CTFs) play an integral role in both physiological processes and disease, and are a topic of interest in mechanobiology. Traction force microscopy (TFM) is a family of methods used to quantify CTFs in a variety of settings. State-of-the-art 3D TFM methods typically rely on confocal fluorescence microscopy, which can impose limitations on acquisition speed, volumetric coverage, and temporal sampling or coverage. In this report, we present the first quantitative implementation of a new TFM technique: traction force optical coherence microscopy (TF-OCM). TF-OCM leverages the capabilities of optical coherence microscopy and computational adaptive optics (CAO) to enable the ...

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      Mentions: Cornell University Steven G. Adie

    7. Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

      Explore OSA | OSA Publishing
      Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

      Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution ...

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      Mentions: University of Western Australia Brendan F. Kennedy

    8. Postdoctoral/Research Fellow Opening at Australian National University

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral/Research Fellow Opening at Australian National University

      Job Title: Postdoctoral/Research Fellow Location: Canberra / ACT Salary package: $71,509 - $111,365 per annum plus 17% superannuation Terms: Full time, Continuing Contingent Funded (1 year with possibility of renewal) Applications close: 02 Apr 2019 11:55:00 PM AUS Eastern Daylight Time Description: The Department of Quantum Science, Research School of Physics and Engineering at the Australian National University has a research collaboration with an industry partner to develop technology for the inspection of inorganic and organic materials. The Postdoctoral / Research Fellow will be a key member of a multi-disciplinary team to develop next-generation automatic three-dimensional volumetric imaging ...

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    9. The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly

      Explore American Journal of Ophthalmology Ophthalmology
      The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly

      Purpose To describe the synergistic benefits and cost-savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab, in the treatment of exudative age-related macular degeneration (AMD) Design Retrospective literature review and personal perspective. Methods Retrospective literature review and personal perspective. Results The introduction of the first clinically useful OCT instrument coincided with early phase clinical trials of a drug that would become known as ranibizumab. OCT provided a non-invasive imaging strategy that unambiguously showed the macular fluid associated with exudative AMD and the ability of anti-VEGF therapy to resolve this fluid ...

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      Mentions: Philip J. Rosenfeld University of Miami

    10. Functional retinal imaging using adaptive optics swept-source OCT at 1.6  MHz

      Explore OSA | OSA Publishing
      Functional retinal imaging using adaptive optics swept-source OCT at 1.6  MHz

      Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus ...

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      Mentions: John S. Werner Robert J. Zawadzki UCSD

    11. Local wavefront mapping in tissue using computational adaptive optics OCT

      Explore OSA | OSA Publishing
      Local wavefront mapping in tissue using computational adaptive optics OCT

      The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Fredrick A. South

    12. Chief Technology Officer Opening at PhotoniCare

      Explore Optical Coherence Tomography News
      Chief Technology Officer Opening at PhotoniCare

      PhotoniCare, Inc. (www.photoni.care) is a medical device manufacturer located in Champaign, IL. We believe better decisions in patient care need to be made at the front lines of medicine, prior to specialty care, so we can improve outcomes and save on downstream healthcare costs. As a result, we’ve developed a low-cost handheld imaging platform that uses light to see through tissue. Our first product on this platform is empowering front- line providers to make better decisions about middle ear infections, the leading cause of hearing loss, antibiotic use, and surgeries in children. PhotoniCare has developed the TOMi ...

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      Mentions: FDA PhotoniCare

    13. PhotoniCare, Inc. Signs Exclusive Distribution Agreement with Adachi Co., LTD to Commercialize the TOMi Scope in Japan

      Explore Optical Coherence Tomography News Other Business News , Partnership
      PhotoniCare, Inc. Signs Exclusive Distribution Agreement with Adachi Co., LTD to Commercialize the TOMi Scope in Japan

      PhotoniCare, Inc., a medical device company headquartered in Champaign, Illinois, has signed an exclusive distribution agreement with Adachi Co., LTD , (Osaka, Japan) to commercialize PhotoniCare’s TOMi ™ Scope device throughout Japan. PhotoniCare’s TOMi Scope uses an advanced light-based technology to see through the eardrum. For the first time, physicians can view a high-resolution depth image on-screen to directly visualize the middle ear contents. Current diagnostic tools can only provide a view of the surface of the eardrum, so physicians are left to guess, or, unfortunately, employ invasive surgical procedures to diagnosis middle ear pathologies. PhotoniCare’s non-invasive solution eliminates ...

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      Mentions: University of Illinois at Urbana-Champaign Ryan L. Shelton PhotoniCare

    14. Deep Learning for Prediction of AMD Progression: A Pilot Study

      Explore IOVS Journal Ophthalmology
      Deep Learning for Prediction of AMD Progression: A Pilot Study

      Purpose : To develop and assess a method for predicting the likelihood of converting from early/intermediate to advanced wet age-related macular degeneration (AMD) using optical coherence tomography (OCT) imaging and methods of deep learning. Methods : Seventy-one eyes of 71 patients with confirmed early/intermediate AMD with contralateral wet AMD were imaged with OCT three times over 2 years (baseline, year 1, year 2). These eyes were divided into two groups: eyes that had not converted to wet AMD ( n = 40) at year 2 and those that had ( n = 31). Two deep convolutional neural networks (CNN) were evaluated using 5-fold cross ...

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      Mentions: Jonathan D. Oakley Voxeleron

    15. Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Explore Journals NDE/NDT
      Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Coral reefs are highly productive photosynthetic systems and coral optics studies suggest that such high efficiency is due to optimized light scattering by coral tissue and skeleton. Here, we characterize the inherent optical properties, i.e. the scattering coefficient, μ s , and the anisotropy of scattering, g , of eight intact coral species using optical coherence tomography (OCT). Specifically, we describe light scattering by coral skeletons, coenoarc tissues, polyp tentacles and areas covered by fluorescent pigments (FP). Our results reveal that light scattering between coral species ranges from μ s = 3 mm −1 ( Stylophora pistillata ) to μ s = 25 mm −1 ( Echinopora lamelosa ) . For ...

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      Mentions: University of Copenhagen Steven L. Jacques Daniel Wangpraseurt

    16. AO-OCT Comes into Focus

      Explore Photonics.com Ophthalmology
      AO-OCT Comes into Focus

      Adaptive optics (AO) technology is often used to correct for wavefront distortions imparted when light travels through complex optical systems, enhancing image resolution and facilitating diffraction-limited optics. It has played a particularly prominent role in ophthalmic imaging, where retinal tissue imaging is limited by inherent aberrations in the eye. Given the widespread adoption of OCT in clinical diagnostics over the last 20 years, these two techniques should be natural partners. But because of technological limitations on both sides, practical applications of AO-OCT have been difficult to implement. Improved imaging AO refers to a family of techniques used for correcting distortions ...

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      Mentions: University of Maryland Daniel X. Hammer Wasatch Photonics

    17. Fried Illuminates the Future of Dentistry

      Explore NIH Record Newsletter Dentistry
      Fried Illuminates the Future of Dentistry

      For anyone who dreads going to the dentist, there may be light at the end of the tunnel. Advances in laser and light-based imaging technologies may soon change the face of modern dentistry. Dr. Daniel Fried Tooth enamel is almost transparent at longer wavelengths, making it possible to shine near-infrared light on a tooth to detect dental decay. “You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube.” Light-based imaging is minimally invasive, providing a safer alternative to an X-ray’s ionizing ...

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      Mentions: Daniel S. Fried UCSF

    18. Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR

      Explore SPIE Digital Library Tunable Sources
      Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR

      A 1060 nm optically pumped tunable VCSEL was formed from an InGaAs/AlGaAs/GaAs half-VCSEL bonded to a MEMS movable mirror on a silicon substrate. The VCSEL was co-packaged in a 14-pin butterfly module with an 825 nm pump laser and a 1060 nm semiconductor optical amplifier. The co-packaged device exhibited shot-noise-limited sensitivity with up to 50 mW output power and 75 nm tunability. Ophthalmic OCT, especially whole-eye imaging and ocular biometry, is considered the primary application of this device. However, we have also investigated LiDAR to greater than 10 meter ranges with non-mechanical beam steering through angular diffraction from ...

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      Mentions: Axsun Technologies Bart Johnson

    19. Soliton microcomb based spectral domain optical coherence tomography

      Explore arxiv.org Broadband Sources
      Soliton microcomb based spectral domain optical coherence tomography

      Spectral domain optical coherence tomography (SD-OCT) has become a widely applied minimally invasive technique for bio-medical imaging[1–4], and industrial process control[5]. One of the most commonly used light source for SD-OCT is based on superluminescent diodes (SLD), which provide a low-noise broadband coverage.[6] Recent advances have allowed creating photonic integrated chipscale frequency combs, that provide an attractive alternative illumination scheme for SD-OCT. Yet to date, the use of such soliton micro-combs in OCT has not been demonstrated or considered. Here we explore the use of soliton microcombs in spectral domain OCT. By using photonic chipscale Si3N4 ...

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      Mentions: Carl Zeiss Meditec Polytechnique Montreal Theo Lasser

    20. BiOS Hot Topics: Changing of the Guard

      Explore Home: SPIE.org
      BiOS Hot Topics: Changing of the Guard

      The near-capacity crowd at their ultimate session this week broke into applause as Rox Anderson opened with "This is the largest meeting in the world for biomedical optics, and that's because of you!" He added that the reason BiOS has grown so popular is the diversity of the intellect and specialties that are featured in the symposium, such as those involved in medicine, bioscience, and physics. James Fujimoto introduced the new BiOS co-chairs, Jennifer Barton of the University of Arizona and Wolfgang Drexler of the University of Vienna. Touching on the impressive backgrounds of each, Fujimoto noted, "we know ...

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      Mentions: James G. Fujimoto Wolfgang Drexler Leiden University

    21. Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      Explore OSA | OSA Publishing
      Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      We propose a simplification for a robust and easy to implement fast phase unwrapping (FPU) algorithm that is used to solve the phase wrapping problem encountered in various fields of optical imaging and metrology. We show that the number of necessary computations using the algorithm can be reduced compared to its original version. FPU can be easily extended from two to three spatial dimensions. We demonstrate the applicability of the two- and three-dimensional FPU algorithm for Doppler optical coherence tomography (DOCT) in numerical simulations, and in the imaging of a flow phantom and blood flow in the human retina in ...

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      Mentions: Nicolaus Copernicus University Maciej Szkulmowski Iwona Gorczynska

    22. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Explore Nature Publishing Group Neurology , Oncology
      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

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      Mentions: Institute of Applied Physics Grigory V. Gelikonov Elena V. Zagaynova

    23. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Explore OSA | OSA Publishing Gastroenterology
      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    24. System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      Explore Optical Coherence Tomography News Jobs & Studentships
      System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      We are looking for In order to support our development department in Lübeck, we are looking for a professionally and personally convincing personality. We offer you an exciting and responsible position in a fast-growing company. Our Lübeck site specialises in OCT technology and systems integration. With your high understanding of systems, you will accompany a project from the initial conception, through the definition of the architecture, the construction of prototypes to testing and handover to production. Your responsibilities System development from the basic concept to production Evaluation of new technological possibilities Definition and elaboration of the system architecture ...

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      Mentions: Heidelberg Engineering
    25. See all articles

  2. Recent Articles From Around The Web

    1. Photonics21 digs in for next phase of continental R&D

      Explore Home: SPIE.org
      Photonics21 digs in for next phase of continental R&D

      Laser pen for ‘while you wait' cancer test The Photonics21 team says that another successful PPP-related development has been delivered by the Automatic Detection of VAscular Networks for Cancer Evaluation (ADVANCE) project team. They have produced a portable laser scanner that can diagnose a malignant melanoma in less than one minute, promising to become what its developers describe as "the world‘s first while-you-wait test for skin cancer." The imaging system, intended to eliminate discomfort and uncertainty for patients, is able to fit every stage of disease identification within the short time of a single doctor's appointment. Using a ...

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      Mentions: Michelson Diagnostics Jon Holmes

    2. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      Explore Optical Coherence Tomography News Gastroenterology , Funding
      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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      Mentions: National Institutes of Health NinePoint Medical Eman Namati

    3. Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Explore The JAMA Network Cardiology
      Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Importance At one end of the coronary artery disease (CAD) spectrum, there are patients with multiple recurrent acute coronary syndromes (rACS), and at the other end there are those with long-standing clinical stability. Predicting the natural history of these patients is challenging because unstable plaques often heal without resulting in ACS. Objective To assess in vivo the coronary atherosclerotic phenotype as well as the prevalence and characteristics of healed coronary plaques by optical coherence tomography (OCT) imaging in patients at the extremes of the CAD spectrum. Design, Setting, and Participants This is an observational, single-center cohort study with prospective clinical ...

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      Mentions: Mount Sinai School of Medicine Massachusetts General Hospital Harvard University

    4. Cross-polarization optical coherence tomography for brain tumor imaging

      Explore Frontiers Neurology
      Cross-polarization optical coherence tomography for brain tumor imaging

      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) – OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An ...

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      Mentions: Institute of Applied Physics Grigory V. Gelikonov Pavel A. Shilyagin

    5. Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Explore Journals | PLOS Cardiology
      Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Background / Objectives Automatic algorithms for stent struts segmentation in optical coherence tomography (OCT) images of coronary arteries have been developed over the years, particularly with application on metallic stents. The aim of this study is three-fold: (1) to develop and to validate a segmentation algorithm for the detection of both lumen contours and polymeric bioresorbable scaffold struts from 8-bit OCT images, (2) to develop a method for automatic OCT pullback quality assessment, and (3) to demonstrate the applicability of the segmentation algorithm for the creation of patient-specific stented coronary artery for local hemodynamics analysis. Methods The proposed OCT segmentation algorithm ...

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    6. Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Explore ScienceDirect Cardiology
      Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Purpose Despite the controversial effect of elevated heart rate on progression of cardiac allograft vasculopathy (CAV), heart-rate-slowing agents are frequently prescribed with the assumption that higher heart rate predicts worse outcomes in cardiovascular disease. Methods This prospective 2-center trial investigated progression of CAV in 116 heart transplant (HTx) patients. Both baseline (1 month after HTx) and follow-up (12 months after HTx) examinations by coronary optical coherence tomography (OCT) were analyzed using highly automated 3D graph-based segmentation software. Mean heart rate was assessed by 24-hour ambulatory ECG monitoring at baseline and at 12-month follow-ups after HTx. Results During the first post-transplant ...

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      Mentions: University of Iowa Milan Sonka

    7. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Explore SPIE Digital Library
      Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

      Optical coherence tomography angiography (OCTA) has been widely used for <i>en face</i> visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the “tail” artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (<i>g</i><sub>1</sub>-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating arterioles from venules in the 3-D image. <i>g</i><sub>1</sub>   (  τ  )   is calculated from repeated optical coherence tomography (OCT) acquisitions for each spatial ...

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      Mentions: Boston University David A. Boas

    8. Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Explore ScienceDirect Cardiology

      Background/Purpose Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality used to assess coronary arteries and as an adjunctive tool for optimization of percutaneous coronary interventions. Overall, the rate of complications and adverse events related to intravascular imaging is low. Limited data exist on the most commonly reported complications and modes of failure related to the use of OCT. Therefore, we analyzed the post-marketing surveillance data from the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to assess the reported complications and failure modes for OCT and reviewed techniques to optimize device use. Methods ...

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    9. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Explore ScienceDirect
      Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Objectives Surgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic algorithm to improve on the current method of clinical evaluation of surgical margin in oral cancer. Materials and methods We have used a modified handheld OCT device with automated algorithm ...

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      Mentions: Zhongping Chen UC Irvine Petra E. Wilder-Smith

    10. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Explore ScienceDirect Cardiology
      Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography

      Objectives This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. Background SCAD is an increasingly recognized cause of acute coronary syndromes , characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation remain poorly understood. Methods A total of 65 SCAD patients (68 vessels) who underwent acute OCT imaging as part of routine clinical care were included. Images were classified by the ...

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      Mentions: Royal Brompton Hospital Gijs van Soest San Carlos University Hospital

    11. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      Explore SPIE Digital Library
      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method is validated on phantoms composed of layers of different materials. Articular cartilage samples from adult swine are segmented with the method. The characteristics in each segmented zone are also examined ...

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      Mentions: University of British Columbia Simon Fraser University Myeong Jin Ju

    13. Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Explore uspto.gov Ophthalmology , Patents
      Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.

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      Mentions: David Huang Oregon Health & Science University Yali Jia

    14. Distance, diameter and area determining device

      Explore uspto.gov Patents
      Distance, diameter and area determining device

      An elongated member such as a catheter that uses ultrasound or optical coherence tomography "OCT") technology to approximate the dimensions of a structure into which the catheter has been placed. The catheter includes multiple ultrasound transducers arranged in an annular or circumferential configuration on, embedded into or within the body of the elongated member so that distance measurements can be obtained between the elongated member and the wall of the immediately facing structure (e.g., a fluid-filled lumen). Utilizing these measurements, the present invention approximates for the physician the shape and size of the structure into which the elongated member ...

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    15. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Explore uspto.gov Ophthalmology , Patents
      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the ...

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      Mentions: Zhongping Chen UC Riverside Wenjuan Qi
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