1. Recent Articles From Around The Web

    1. Disease activation maps for subgingival dental calculus identification based on intelligent dental optical coherence tomography

      Disease activation maps for subgingival dental calculus identification based on intelligent dental optical coherence tomography

      During the treatment of periodontitis, removal of dental calculus is essential but still tricky despite developments of several imaging modalities. In this research, we propose a novel approach to provide an intuitive guidance, to automatically detect the present of subgingival calculus, and to identify the site of the lesion in optical coherence tomography images based on convolutional neural network model and the class activation maps technique. Our result shows good visualizations of dental calculus both in B‐scan and in volumetric view. We believe the improvement can break down the technical barrier and finally facilitate the prevalence of dental optical ...

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    2. Acute coronary syndrome demonstrating plaque rupture in calcified plaque visualized by optical coherence tomography and near-infrared spectroscopy combined with intravascular ultrasound

      Acute coronary syndrome demonstrating plaque rupture in calcified plaque visualized by optical coherence tomography and near-infrared spectroscopy combined with intravascular ultrasound

      Optical coherence tomography (OCT) can visualize calcification of the coronary plaque as a low-intensity lesion with sharp borders. However, residual lipid tissue inside the calcification could pose a problem in plaque evaluation by OCT. We present a case of acute coronary syndrome (ACS) demonstrating plaque rupture in the calcified plaque. In this case, OCT demonstrated a cavity suspected to represent rupture in the calcified plaque and near-infrared spectroscopy revealed a lipid component behind the calcified plaque. Although calcified plaque is not considered a reason for ACS except for calcified nodules, residual lipid tissue inside the calcification might cause ACS if ...

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    3. Utilization of Optical Coherence Tomography to Assess Coronary Vessel Constriction after Ablation

      Utilization of Optical Coherence Tomography to Assess Coronary Vessel Constriction after Ablation

      Epicardial ablations are being utilized as alternative techniques to the current endocardial procedures. An epicardial approach offers some advantages, especially when treating ventricular arrhythmias, e.g., those that have epicardial or transmural sites of origin. However the potential collateral damage from these applied myocardial surface ablations has not been fully explored. In order to better visualize and understand such effects on acute coronary functioning, we have employed intracoronary optical coherence tomography (OCT) of ablated cardiac tissues. Ex-vivo swine hearts were reanimated utilizing Visible Heart® Laboratories methodologies, then the midsection of the LAD was anatomically characterized via OCT before and after ...

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    4. Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study

      Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study

      Background: Central serous chorioretinopathy (CSC) is a common macular condition characterized by detachment of the neuroretina and is a frequent cause of central vision loss in adults. Among the various therapeutic strategies, subthreshold microsecond pulsed laser (SML) treatment has become a useful option. Despite the suggested involvement of choroidal circulatory disturbances in CSC, effects of this treatment on macular microperfusion have not been fully evaluated yet. Herein, we report the impact of SML on retinal and choroidal microvascular flow using non-invasive optical coherence tomography (OCT) angiography (OCTA). Methods: In this study, CSC patients with persistent subretinal fluid (SRF) with or ...

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    5. Optical coherent tomography for the diagnostic of non-obstructive coronary artery myocardial infarction

      Optical coherent tomography for the diagnostic of non-obstructive coronary artery myocardial infarction

      Funding Acknowledgements Type of funding sources: None. The widespread use of coronary angiography (CAG) in patients with acute coronary syndrome led to the understanding that in some patients myocardial infarction (MI) occurs against angiographically unchanged or slightly modified coronary arteries (CA). In such cases, the so-called "type 2 IM" is diagnosed in some patients, however, to determine the true cause of MI, a modern method of investigation such as optical coherence tomography (OCT) is needed to visualize the intima of the CA and detect a minimal atherosclerotic process. The purpose of the study was to establish the etiology of MI ...

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    6. Deep Learning-based Diagnosis of Glaucoma Using Wide-field Optical Coherence Tomography Images

      Deep Learning-based Diagnosis of Glaucoma Using Wide-field Optical Coherence Tomography Images

      Purpose: (1) To evaluate the performance of a deep learning (DL) classifier in detecting glaucoma, based on wide-field swept-source optical coherence tomography (SS-OCT) images. (2) To assess the performance of DL-based fusion methods in diagnosing glaucoma using a variety of wide-field SS-OCT images and compare their diagnostic abilities with that of conventional parameter-based methods. Methods: Overall, 675 eyes, including 258 healthy eyes and 417 eyes with glaucoma were enrolled in this retrospective observational study. Each single-page wide-field report (12×9 mm) of wide-field SS-OCT imaging provides different types of images that reflect the state of the eyes. A DL-based automated ...

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    7. Optical Coherence Tomography Angiography following Scleral Buckling Surgery

      Optical Coherence Tomography Angiography following Scleral Buckling Surgery

      Introduction: The retinal changes following scleral buckling surgery (SBS) for rhegmatogenous retinal detachment (RRD) have been rarely evaluated with optical coherence tomography angiography (OCTA). Methods: A 40 years old male presented with subtotal RD involving the macula and had best corrected visual acuity of logmar 2.3 in the affected right eye. Five months after applying 120 degree scleral buckle, swept source optical coherence tomography (SSOCT) and swept source optical coherence tomography angiography (SS-OCTA) were done. Result: At five months post-surgery, despite a settled retina in the operated eye, the patient had vision of logmar 1 and thin retinal nerve ...

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    8. Capsule Network-based architectures for the segmentation of sub-retinal serous fluid in optical coherence tomography images of central serous chorioretinopathy

      Capsule Network-based architectures for the segmentation of sub-retinal serous fluid in optical coherence tomography images of central serous chorioretinopathy

      Central serous chorioretinopathy (CSCR) is a chorioretinal disorder of the eye characterized by serous detachment of the neurosensory retina at the posterior pole of the eye. CSCR results from the accumulation of subretinal fluid (SRF) due to idiopathic defects at the level of the retinal pigment epithelial (RPE) that allows serous fluid from the choriocapillaris to diffuse into the subretinal space between RPE and neurosensory retinal layers. This condition is presently investigated by clinicians using invasive angiography or non-invasive optical coherence tomography (OCT) imaging. OCT images provide a representation of the fluid underlying the retina, and in the absence of ...

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    9. Functional regulation of an outer retina hyporeflective band on optical coherence tomography images

      Functional regulation of an outer retina hyporeflective band on optical coherence tomography images

      Human and animal retinal optical coherence tomography (OCT) images show a hyporeflective band (HB) between the photoreceptor tip and retinal pigment epithelium layers whose mechanisms are unclear. In mice, HB magnitude and the external limiting membrane-retinal pigment epithelium (ELM-RPE) thickness appear to be dependent on light exposure, which is known to alter photoreceptor mitochondria respiration. Here, we test the hypothesis that these two OCT biomarkers are linked to metabolic activity of the retina. Acetazolamide, which acidifies the subretinal space, had no significant impact on HB magnitude but produced ELM-RPE thinning. Mitochondrial stimulation with 2,4-dinitrophenol reduced both HB magnitude and ...

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    10. Volume Rendering of Angiographic Optical Coherence Tomography Angiography in Fovea Plana and Normal Foveal Pit

      Volume Rendering of Angiographic Optical Coherence Tomography Angiography in Fovea Plana and Normal Foveal Pit

      This paper aims to study adaptative vascular arrangements in idiopathic fovea plana with volume-rendered optical coherence tomography angiography (OCTA). A retrospective review of two cases of idiopathic fovea plana (mean age: 26.5 years) and two age-matched controls imaged with OCTA was conducted using spectral-domain OCTA (RTVue XR Avanti, Optovue, Inc., Fremont, CA) equipped with the AngioVue software. Both en face OCTA slabs and OCTA b scans were processed through Fiji software (http://fiji.sc; software version 2.0.0-rc-68/1.52e), and then extracted as image sequences for volume rendering reconstructions using the ImageVis3D volume rendering system (3.1 ...

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    11. Cilioretinal Arteries Influence Optic Nerve Head, Peripapillary and Macular Vessel Densities in Healthy Eyes - An Optical Coherence Tomography Angiography Study

      Cilioretinal Arteries Influence Optic Nerve Head, Peripapillary and Macular Vessel Densities in Healthy Eyes - An Optical Coherence Tomography Angiography Study

      Aim: To analyze the influence of a cilioretinal artery on macular and peripapillary vessel density in healthy eyes as measured using optical coherence tomography angiography (OCTA). Methods: 83 eyes of 83 patients were included in this study. Optical coherence tomography angiography was performed using the RTVue XR Avanti with AngioVue (Optovue Inc).The macula was imaged with a 3 × 3-mm scan, whereas for the optic nerve head (ONH) a 4.5 × 4.5-mm scan was taken. OCTA images of the ONH were screened for the presence of a CRA. Results: In 31 eyes, a CRA was detected (37,3%). The ...

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      Mentions: Optovue
    12. A spatial resolution evaluation method of endoscopic optical coherence tomography system using the annular phantom

      A spatial resolution evaluation method of endoscopic optical coherence tomography system using the annular phantom

      As an important biomedical imaging method, endoscopic optical coherence tomography (OCT) is necessary to check its performance regularly. The ordinary plane phantoms are only able to evaluate part of image tangent to the probe. In this research, a spatial resolution estimate method of the endoscope OCT system is proposed. The annular phantom, made by uniformly distributing golden scattered microparticles in polydimethylsiloxane (PDMS), can provide dynamic scanning imaging evaluation of endoscopic OCT system, closer to its actual working status. The point spread function (PSF) analysis method is used to analyze the imaging results of the annular phantom with the endoscopic OCT ...

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    13. Utilization of spectral domain optical coherence tomography to identify posterior vitreous detachment in patients with a retinal detachment

      Utilization of spectral domain optical coherence tomography to identify posterior vitreous detachment in patients with a retinal detachment

      Purpose: To compare posterior vitreous detachment (PVD) identification rate between clinical examination vs. spectral domain optical coherence tomography (SD-OCT) in patients with retinal detachment (RD). Methods: Data from the Primary Retinal detachment Outcomes (PRO) study was utilized for this retrospective cross-sectional study of 506 patients. SD-OCT scans were reviewed to detect separation of the posterior hyaloid face from the retina and the optic nerve on all 31 raster cuts of a 30 x 30 scan. Statistical analysis was performed to compare SD-OCT identified PVD with PVD identified on slit lamp biomicroscopy. Results: There was a significant difference in rate of ...

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    14. Volumetric Optical Imaging and Quantitative Analysis of Age-Related Changes in Anterior Human Vitreous

      Volumetric Optical Imaging and Quantitative Analysis of Age-Related Changes in Anterior Human Vitreous

      Purpose : The purpose of this study was to characterize age-related changes in anterior human vitreous with 3-D swept source optical coherence tomography (SS-OCT) and evaluate associations with axial length (AL) and contrast sensitivity function (CSF). Methods : There were 49 phakic eyes in 49 patients (40.0 ± 19.3 years) had 3-D volumetric scanning of the lens and retrolental vitreous with SS-OCT at 1050 nm. OCT-derived indices of vitreous optical density (VOD), vitreous opacification ratio (VOR), and lens optical density (LOD) were correlated with AL and double-pass assessment of retinal point spread function (Objective Scatter Index [OSI]). CSF was measured using ...

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    15. Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation

      Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation

      Purpose: To investigate the characteristics of treatment-naïve nonexudative macular neovascularization (MNV) in age-related macular degeneration before the onset of exudation using swept-source optical coherence tomography angiography. Methods: MNV area, choriocapillaris (CC) flow deficits (FDs), vessel area density (VAD), vessel skeleton density (VSD), retinal pigment epithelial detachment (PED) volume, mean choroidal thickness (MCT), and choroid vascularity index (CVI) measurements were assessed at two visits prior to exudation. We compared measurements made at the second visit and the rate of change between visits in eyes with and without exudation. The differences in these parameters between eyes with and without subsequent exudation ...

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    A Reliable Business Process Management & Outsourcing Company Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital A review of low-cost and portable optical coherence tomography Microparticle-Based Biochemical Sensing Using Optical Coherence Tomography and Deep Learning AI Spots Individual Neurons in the Eye Better than Human Expert Nanoscope presents novel gene delivery and electrophysiology platforms at ARVO Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections 4-D Imaging of Beating Tissues using Optical Coherence Tomography Disease activation maps for subgingival dental calculus identification based on intelligent dental optical coherence tomography Acute coronary syndrome demonstrating plaque rupture in calcified plaque visualized by optical coherence tomography and near-infrared spectroscopy combined with intravascular ultrasound
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu