1. Feature Of The Week Section is on Vacation until September

    The Feature of the Week Section is on summary vacation till September due to large fraction of OCT News subscribers being on a holiday schedule.
  2. Recent Articles From Around The Web

    1. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Speckle statistics of flowing scatterers have been well documented in the literature. Speckle variance optical coherence tomography exploits the large variance values of intensity changes in time caused mainly by the random backscattering of light resulting from translational activity of red blood cells to map out the microvascular networks. A method to map out the microvasculature malformation of skin based on the time-domain histograms of individual pixels is presented with results obtained from both normal skin and skin containing vascular malformation. Results demonstrated that this method can potentially map out deeper blood vessels and enhance the visualization of microvasculature in ...

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    2. Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinica

      Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinica

      Aims: Little is known about the respective healing responses and clinical efficacy and safety of drug-eluting balloons (DEB) and the second generation of drug-eluting stents (DES) when used to treat in-stent restenosis (ISR). In this study, we set out to compare prospectively the healing characteristics, as assessed by optical coherence tomography (OCT), of DEB versus DES after treatment of ISR in bare metal stents (BMS). Methods and results: Fifty patients with BMS ISR were randomised to treatment with a paclitaxel-eluting balloon vs. an everolimus-eluting stent (EES). The primary endpoint was the percentage of uncovered struts, assessed with OCT at nine ...

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    3. Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

      Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

      Purpose: To compare the abilities of standard automated perimetry (SAP) and spectral-domain optical coherence tomography (SDOCT) in diagnosing eyes with glaucomatous optic neuropathy (GON). Methods: In a cross-sectional study, 280 eyes of 175 subjects referred to tertiary eye care center by general ophthalmologists for a glaucoma evaluation underwent retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) imaging with SDOCT. All subjects had at least 2 reliable and repeatable SAP. Two glaucoma experts masked to clinical and SAP results classified the optic nerves into GON and nonglaucomatous groups based on digital optic disc photographs. Ability of SDOCT parameters and ...

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      Mentions: Harsha L. Rao
    4. Optical Coherence Tomography of a Cystic Retinal Tuft

      Optical Coherence Tomography of a Cystic Retinal Tuft

      Cystic retinal tuft (CRT) is a developmental vitreoretinal abnormality found in 5% of autopsy eyes. Clinical examination reveals a focal, elevated gliotic lesion in the peripheral retina associated with vitreous traction (Figure, A and B). Histopathological analysis demonstrates a dome-shaped area with internal microcysts, glial cell proliferation, outer retinal degeneration, and photoreceptor loss.

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    5. A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography

      A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography

      Introduction Since optical coherence tomography (OCT) is well suited for measuring small dimensional changes on tooth surfaces, OCT has great potential for monitoring tooth erosion. Previous studies have shown that enamel areas ablated by a carbon dioxide laser manifested lower rates of erosion compared to the non-ablated areas. The purpose of this study was to develop a model to monitor erosion in vitro that could potentially be used in vivo . Methods Thirteen bovine enamel blocks were used in this in vitro study. Each 10 mm × 2 mm block was partitioned into five regions, the central region was unprotected, the adjacent ...

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    6. Optical coherence tomography demonstrating macular retinal nerve fiber thinning in advanced optic disc drusen

      Optical coherence tomography demonstrating macular retinal nerve fiber thinning in advanced optic disc drusen

      Optic disc drusen (ODD) are extracellular proteinaceous excrescences in the optic nerve head. They enlarge over time and can cause damage to nerve fibers with resulting loss of visual field. The authors report a case of advanced ODD in which macular optical coherence tomography demonstrated retinal nerve fiber thinning. A single case report of a 42-year-old woman with known ODD presented to the eye clinic with worsening field of vision which was impacting on her daily life. The patient was subject to full ophthalmic examination as well as Goldmann visual field testing, optic disc photography and optical coherence tomography (OCT ...

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    7. UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      University of California at Irvine Received a 2014 NIH Grant for $598,705 for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging. The principal investigator is Zhongping Chen. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution ...

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    8. Optical coherence tomography as highly accurate optical tracking system

      Optical coherence tomography (OCT) guided laser cochleostomy enables the ablation accuracy on tens of micrometer scale and therefore also requires a high patient tracking accuracy on the same order of magnitude, which however exceeds the ability of the conventional optical or electromagnetic tracking systems. We have developed a novel approach of using OCT itself as a highly accurate optical tracking system by ablating tiny artificial landmarks surrounding the cochleostomy on the target bone surface and locating them in the online acquired 3D OCT Volumes. The mechanism enables a direct tracking of the target area with respect to the laser optics ...

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    9. Fractional Flow Reserve and Optical Coherence Tomography

      Fractional Flow Reserve and Optical Coherence Tomography

      Angiography has long been considered the gold standard in guiding coronary interventional therapies. However, well-documented limitations of angiography necessitate the use of more advanced imaging and functional hemodynamic evaluation to arrive at optimal decisions regarding revascularization.1 Contemporary guideline-driven practice dictates revascularization only for ischemia-causing lesions and medical therapy for other lesions.2,3 For this reason, accurate assessment of the functional significance of a lesion (ischemic vs. nonischemic) using noninvasive or invasive techniques is very important.

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    10. Optical Coherence Tomography Velocimetry of Colloidal Suspensions

      Optical Coherence Tomography Velocimetry of Colloidal Suspensions

      Optical coherence tomography velocimetry combined with a rheometer and optical modulation techniques provides increased sensitivity to the low shear rate motion of complex fluid systems. Optical modulation coupled with a new interferometer design yields improved signal to noise ratios and is demonstrated with optically opaque colloidal suspensions. Thus the measureable range of shear velocities with complex fluids can be as low as ~40 µms-1, more than an order of magnitude improvement on the previous lower limit of ~700 µms-1. Furthermore the apparatus demonstrates improved sensitivity to the measurement of velocity. The instrument was used to study two hard sphere colloidal ...

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    11. SEDUCEd by optical coherence tomography in drug-eluting balloon assessment

      SEDUCEd by optical coherence tomography in drug-eluting balloon assessment

      In everyday practice, percutaneous coronary intervention using a bare metal stent (BMS) is still frequently performed and the chance of incurring in-stent restenosis (ISR) is not negligible. Different treatment modalities for BMS ISR are still an important area of discussion. One of the most appealing is the drug-eluting balloon (DEB). This device has been proven angiographically and clinically superior to an uncoated balloon in BMS ISR1,2. Moreover, in the same type of lesion, DEBs have also shown angiographic and clinical results at least comparable to first-generation drug-eluting stents (DES), with a trend towards lower angiographic restenosis and lower ...

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    12. Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

      Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

      Purpose To evaluate the effect of optic nerve head drusen (ONHD) on the retinal nerve fiber layer (RNFL) and macular ganglion cell–inner plexiform layer (GCIPL) using Cirrus optical coherence tomography (OCT). Methods Fifty-seven eyes of thirty patients with ONHD and thirty-eight eyes of twenty age-matched and sex-matched control subjects underwent circumpapillary and macular scanning using Cirrus OCT. The percentages of eyes with abnormal GCIPL and RNFL values according to the Cirrus normative data were analysed and compared. Results Overall, eyes with ONHD showed abnormally reduced values for average and minimum GCIPL thicknesses in 35 % and 45 % of cases compared ...

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    13. Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Purpose To describe a spectral domain optical coherence (OCT)-assisted method of measuring retinal vessel diameters. Methods All Patients with an OCT circle scan centered at the optic nerve head using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels both on IR and spectral domain OCT (SD-OCT). Vessel width and vessel types obtained by IR were documented as ground truth. From OCT, measurements of each vessel, including horizontal vessel contour diameter, vertical vessel contour diameter, horizontal hyperreflective core diameter, and reflectance shadowing width, were ...

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    14. Postdoctoral Research Associate at University of Liverpool

      Postdoctoral Research Associate at University of Liverpool

      £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include OCT sensor instrumentation ...

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    15. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this study, the potential of combining structural information from optical coherence tomography (OCT) and molecular information from line-scan Raman microscopy (LSRM) for such an application is presented. The results show a ...

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  2. Organizations in the News

    1. (3 articles) Case Western Reserve University
    2. (2 articles) National Institutes of Health
    3. (1 articles) University of Catania
    4. (1 articles) University of Houston
    5. (1 articles) Medical University of Vienna
    6. (1 articles) Azienda Ospedaliera San Paolo
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  3. People in the News

    1. (2 articles) Michael W. Jenkins
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    5. (1 articles) Daniel S. Fried
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    13. (1 articles) Hui Wang
    14. (1 articles) Eric J. Seibel
    15. (1 articles) Takashi Kubo
  4. OCT Companies in the News

    1. (3 articles) Carl Zeiss Meditec
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    3. (1 articles) Heidelberg Engineering
  5. OCT Products in the News

    1. (1 articles) Zeiss Cirrus HD-OCT
    2. (1 articles) Heidelberg Spectralis
  6. Picture Gallery

    Three-dimensional optical coherence micro-elastography of skeletal muscle tissue University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas Utilizing Optical Coherence Tomography in the Nondestructive and Noncontact Measurement of Egg Shell Thickness Postdoctoral Opening at Biophotonics Laboratory at Yale University Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring Optical biopsy approaches in Barrett’s esophagus with next-generation optical coherence tomography High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation Senior Scientist Position Open at Carl Zeiss Meditec in Dublin California Novel endoscopic diagnosis for bladder cancer Volcano Corporation to Divest Axsun and Settle All Ongoing Litigation with St. Jude Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography
  7. Recent Quotes

    1. Given the promising results in laboratory animal and clinical studies, we are hoping to bring this technology into the Veterinary Teaching Hospital for imaging during cancer surgery in animals.
      By Laura Selmic
    2. With respect to the planned Axsun divestiture, this decision was driven by our long-term strategy to focus on coronary imaging and physiology leadership, peripheral expansion, profitability and business scale. The Axsun business and financial model is no longer a strategic fit with Volcano. We greatly appreciate the significant contributions of the Axsun team to Volcano over the past several years.
      By Scott Huennekens
    3. This partnership is a significant milestone in the transformation of ACIST, and will help us to achieve rapid and significant penetration of the U.S. market.
      By Tom Morizio
    4. Neurophotonics provides a highly visible focal point to facilitate and accelerate the rapidly expanding impact of this discipline.
      By David Boas
    5. Tooth enamel is almost completely transparent in the near-infrared. We showed that you could take an OCT image of a lesion and tell how severe it is. Previously the only option was to extract the tooth and cut it open for closer inspection. Dental decay isn't like cancer. You can actually treat it, arrest it and even reverse it. If you spot the lesions early enough, you can treat them with fluoride and re-mineralize them, and you can measure this with OCT. It gives the clinician a way of telling whether the chemical intervention is working.
      By Daniel S. Fried
    6. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions.
      By Yu Chen
    7. That's why these correlations are important, so that in the future we can be confident regarding the relationship of OCT to MRI, and perhaps be able to use OCT as an additional tool more upfront to help in the diagnosis.
      By Laura Balcer
    8. We are excited about the success story of intraoperative OCT in ophthalmology
      By Eva Lankenau
    9. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions...Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord...An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen
    10. An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen