1. Featured Articles

    1. Image Data Analyst, GlaxoSmithKline Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Explore Optical Coherence Tomography News Jobs & Studentships
      Image Data Analyst, GlaxoSmithKline Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Image Data Analyst GlaxoSmithKline Center for Optical Molecular Imaging Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign The GlaxoSmithKline Center for Optical Molecular Imaging at the Beckman Institute for Advanced Science and Technology seeks a bright, energetic, and motivated candidate to fill a vacancy for a full-time Image Data Analyst. The purpose of this position is to lead the analysis of image data from translational optical biomedical imaging systems. The successful candidate will need a solid and broad understanding of image analysis software as well as software development including high-level user interface requirements in a Windows ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign

    2. Imaging Research Scientist, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Explore Optical Coherence Tomography News Jobs & Studentships
      Imaging Research Scientist, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      The Biophotonics Imaging Laboratory and the Center for Optical Molecular Imaging at the Beckman Institute for Advanced Science and Technology seek to fill a position for a full-time Imaging Research Scientist. The purpose of this position is to develop and operate optical imaging technologies and systems, and perform and/or manage translational imaging studies involving cell lines, pre-clinical animal models, human subjects, and/or human tissue specimens. This position will work closely with research personnel and physicians, and will also interface with industry partners and collaborators at GlaxoSmithKline. Duties and Responsibilities: Innovate and develop novel optical imaging systems, including both ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign

    3. Feature Issue of Biomedical Optics Express: Progress in Multimodal En-Face Imaging Manuscript Deadline September 15, 2018

      Explore Optical Coherence Tomography News
      Feature Issue of Biomedical Optics Express: Progress in Multimodal En-Face Imaging Manuscript Deadline September 15, 2018

      Biomedical Optics Express welcomes submissions to a feature issue on "Progress in Multimodal En-Face Imaging". Multimodal optical imaging certainly enriches the amount of information that can be retrieved from biological tissue. For this purpose, many different approaches have been combined, including optical coherence tomography (OCT), microscopy, scanning laser ophthalmoscopy (SLO), fluorescence imaging, multi-photon imaging, Raman spectroscopy, photoacoustics, and many more. This year marks 20 years from the publication of a first report on a combination of the old SLO, dating back from 1980, and of OCT, at that time a rather novel imaging technique as it was just invented in ...

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      Mentions: Joseph A. Izatt Duke University Adrian G. Podoleanu

    4. In vivo detection of UV-induced acute skin effects using optical coherence tomography

      Explore OSA | OSA Publishing Dermatology
      In vivo detection of UV-induced acute skin effects using optical coherence tomography

      Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo . To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore, the same skin area was repeatedly scanned with OCT during UV irradiation to investigate the progress of the induced acute effects and after irradiation for observation of skin recovery. Subsequently ...

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      Mentions: National Taiwan University Meng-Tsan Tsai Chang Gung University

    5. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

      Explore OSA | OSA Publishing Gastroenterology
      Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

      Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a ...

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      Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam VU University Amsterdam

    6. A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging

      Explore Wiley Online Library Dermatology
      A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging

      A compact high‐speed full‐field optical coherence microscope has been developed for high‐resolution in vivo imaging of biological tissues. The interferometer, in the Linnik configuration, has a size of 11×11×5 cm 3 and a weight of 210 g. Full‐field illumination with low‐coherence light is achieved with a high‐brightness broadband light‐emitting diode. High‐speed full‐field detection is achieved by using part of the image sensor of a high‐dynamic range CMOS camera. En face tomographic images are acquired at a rate of 50 Hz, with an integration time of 0.9 ms ...

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      Mentions: Arnaud Dubois Institut d'Optique

    7. Thorlabs Releases New MEMS‐VCSEL Swept‐Wavelength Laser Sources

      Explore Optical Coherence Tomography News Other Business News , Tunable Sources
      Thorlabs Releases New MEMS‐VCSEL Swept‐Wavelength Laser Sources

      Thorlabs announced today that it has released next‐generation versions of its 1300 nm MEMS‐VCSEL Swept‐Wavelength Laser Sources. With a record‐breaking coherence length of over 100 mm and sweep rates of either 100 kHz or 200 kHz, the SL131090 and SL132120 are the only commercially available MEMS‐VCSEL laser sources on the market. Based on a patented microelectromechanical system (MEMS) tunable vertical cavity surface emitting laser (VCSEL), these light sources include an active power control that maintains constant output power over the lifetime of the laser. All drive electronics and trigger signals needed to seamlessly integrate these ...

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      Mentions: Thorlabs

    8. Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

      Explore SPIE Digital Library
      Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

      iagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation were performed. OCT can reliably differentiate between fat, cystic, and regular atrophy and benign glands. The overall sensitivity and specificity for malignancy detection was 79% and 88% for reviewer 1 ...

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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    9. Spectroscopic characterization of Si/Mo thin-film stack at extreme ultraviolet range

      Explore OSA | OSA Publishing NDE/NDT , Other Non-Medical
      Spectroscopic characterization of Si/Mo thin-film stack at extreme ultraviolet range

      A noninvasive method for characterizing Si/Mo thin-film stack thickness and its complex transfer function using common-path optical coherence tomography is proposed, analyzed, and experimentally demonstrated. A laser-produced plasma (LPP)-based extreme ultraviolet (EUV) source was excited by a four-stage nanosecond Yb:fiber laser amplifier with a pulse energy of 1.01 mJ. The tabletop LPP EUV source was compact and stable for generating the EUV interference fringes. The measured complex transfer function of the Si/Mo stack was verified near the pristine 13.5-nm wavelength range.

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      Mentions: National Taiwan University Sheng-Lung Huang

    10. Group refractive index and group velocity dispersion measurement by complex master slave interferometry

      Explore OSA | OSA Publishing
      Group refractive index and group velocity dispersion measurement by complex master slave interferometry

      This paper demonstrates that the complex master slave interferometry ( CMSI ) method used in spectral domain interferometry ( SDI ) can efficiently be used for accurate refractive index and group velocity dispersion measurements of optically transparent samples. For the first time, we demonstrate the relevance of the phase information delivered by CMSI for dispersion evaluations with no need to linearize data. The technique proposed here has been used to accurately measure the group refractive index and the group velocity dispersion of a strong dispersive sample (SF6 glass), and a weak dispersive one (distilled water). The robustness of the technique is demonstrated through the ...

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      Mentions: Adrian G. Podoleanu University of Kent Adrian Bradu

    11. Masters of Science in Optical Coherence Tomography at the University of Kent

      Explore Optical Coherence Tomography News Jobs & Studentships
      Masters of Science in Optical Coherence Tomography at the University of Kent

      Optical Coherence Tomography (OCT) is having a dramatic impact on the diagnosis and management of eye disease, and offers a wide range of career prospects in research and industry. Come and study the principles of spectral and time domain interferometry, and learn how progress in the fibre optics and laser industry has shaped OCT technology. In this one-year programme, students will develop an experimental project under the supervision of one of the four academics of the Applied Optics Group (AOG) which has long and extensive experience in OCT. Projects can be selected from a wide range of areas, including tissue ...

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      Mentions: Adrian G. Podoleanu University of Kent

    12. Post-doctoral Research Fellow Position and 2 PhD Studentships in Ophthalmic Imaging at the Nicolaus Copernicus University, Torun, Poland

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post-doctoral Research Fellow Position and 2 PhD Studentships in Ophthalmic Imaging at the Nicolaus Copernicus University, Torun, Poland

      The Bio-Optics & Optical Engineering Lab at the Nicolaus Copernicus University invites applications for the positions in a project entitled Lenticular and vitreal light scattering and refraction for tomorrow's eye diagnostics financed by the Foundation for Polish Science (Programme TEAM) from the Smart Growth Operational Programme funds (PO IR) in 2014-2020. We are seeking young researchers for the following positions: Post-doctoral Research Fellow, and PhD students (2x). The project aims at the development and clinical validation of novel imaging-based tools to extract spatially resolved information on the light scattering and refraction in the ocular structures and media. The project addresses ...

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      Mentions: Nicolaus Copernicus University Ireneusz Grulkowski

    13. Clinically applicable deep learning for diagnosis and referral in retinal disease

      Explore Nature Publishing Group Ophthalmology
      Clinically applicable deep learning for diagnosis and referral in retinal disease

      The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great promise in classifying two-dimensional photographs of some common diseases and typically relies on databases of millions of annotated images. Until now, the challenge of reaching the performance of expert clinicians in a real-world clinical pathway with three-dimensional diagnostic scans has remained unsolved. Here, we apply a novel deep learning architecture to a clinically heterogeneous set of three-dimensional optical coherence tomography scans from patients referred to a major eye hospital. We demonstrate performance in ...

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      Mentions: University College London Adnan Tufail Pearse A. Keane

    14. Now Google's DeepMind's AI can spot eye disease just as well as your doctor

      Explore WIRED UK Ophthalmology
      Now Google's DeepMind's AI can spot eye disease just as well as your doctor

      When Pearse Keane started using optical coherence tomography (OCT) scanners to peer to the back of a person's eye in Los Angeles a decade ago, the machines were relatively crude. "The devices were lower resolution, they had much slower image acquisition speeds," says Keane, a consultant ophthalmic surgeon at Moorfields Eye Hospital and researcher at University College, London. From 2007, Keane spent two years studying scans from OCT machines learning to diagnose eye conditions in patients and pick out the minute details which make up sight-threatening diseases. "It was very time consuming, laborious work," Keane says. OCT scans use ...

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      Mentions: University College London Pearse A. Keane

    16. Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      Explore OSA | OSA Publishing Tunable Sources
      Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to ...

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      Mentions: Robert A. Huber University of Lübeck Technical University of Munich

    17. Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis

      Explore The JAMA Network Otolaryngology
      Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis

      Importance Recurrent respiratory papillomatosis (RRP) is a viral-induced disease caused by human papillomavirus and the second leading cause of dysphonia in children; however, neither a cure nor a definitive surgical treatment is currently available for RRP. Although laser therapy is often used in the treatment of RRP, the lack of real-time laser-tissue interaction feedback undermines the ability of physicians to provide treatments with low morbidity. Therefore, an intraoperative tool to monitor and control laser treatment depth is needed. Objective To investigate the potential of combining optical coherence tomography (OCT) with laser therapy for patient-tailored laryngeal RRP treatments. Design, Setting, and ...

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      Mentions: Harvard University Boston Scientific Cambridge Technology

    18. Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Explore OSA | OSA Publishing Dentistry
      Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Early detection of dental caries is known to be the key to the effectiveness of therapeutic and preventive approaches in dentistry. However, existing clinical detection techniques, such as radiographs, are not sufficiently sensitive to detect and monitor the progression of caries at early stages. As such, in recent years, several optics-based imaging modalities have been proposed for the early detection of caries. The majority of these techniques rely on the enhancement of light scattering in early carious lesions, while a few of them are based on the enhancement of light absorption at early caries sites. In this paper, we report ...

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    19. Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Explore Optical Coherence Tomography News Jobs & Studentships
      Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Job Description This opening is for a senior mechanical engineer who will be responsible for the design and development and manufacturing of several intravascular catheters and pullback devices used in intravascular imaging. Senior mechanical engineer will develop disposable devices following FDA regulatory standards, by working in coordination with regulatory professionals, optical engineers and software professionals in the company. Moreover, senior mechanical engineer will, maintain history files of product designs, and make changes by working in close coordination with end-users as needed. This position requires a bachelor’s degree in mechanical engineering with 10 years’ experience in medical device industry or ...

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      Mentions: FDA OCT Medical Imaging Inc

    20. Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Now available is a position for a Postdoc in Biomedical Optics, Biophotonics, Photonics or Optical Microscopy | Ref: 502043 | SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY Two year appointment Salary range: Level A $68,452 – $97,497 p.a. or Level B $97,310 – $115,350 p.a. (dependent on qualifications and experience) Postdoc in Biomedical Optics/Biophotonics/Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top 100 universities in the world and a member of the prestigious Australian Group of Eight research-intensive universities. With an enviable research track record, vibrant campus ...

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      Mentions: David D. Sampson University of Western Australia

    21. Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      Explore MDPI Open Access Journals Platform NDE/NDT
      Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      The non-destructive classification of plant materials using optical inspection techniques has been gaining much recent attention in the field of agriculture research. Among them, a near-infrared (NIR) imaging method called optical coherence tomography (OCT) has become a well-known agricultural inspection tool since the last decade. Here we investigated the non-destructive identification capability of OCT to classify diversely stained (with various staining agents) Capsicum annuum seed specimens of different cultivars. A swept source (SS-OCT) system with a spectral band of 1310 nm was used to image unstained control C. annuum seeds along with diversely stained Capsicum seeds, belonging to different cultivar ...

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      Mentions: Medical University of Vienna Jeehyun Kim Kyungpook National University

    22. Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Explore bioRxiv.org NDE/NDT
      Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Coral reefs are highly productive photosynthetic systems and coral optics studies suggest that such high efficiency is due to optimised light scattering by coral tissue and skeleton. Here, we characterise the inherent optical properties, i.e., the scattering coefficient, μ s , and the anisotropy of scattering, g , of 8 intact coral species using optical coherence tomography (OCT). Specifically, we describe light scattering by coral skeletons, coenoarc tissues, polyp tentacles and areas covered by fluorescent pigments (FP). Our results reveal that light scattering between coral species ranges from μ s = 3 mm -1 ( Stylophora pistillata ) to μ s = 25 mm -1 ( Echinopora lamelosa ). For ...

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      Mentions: Steven L. Jacques Daniel Wangpraseurt Michael Kühl

    23. Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Explore OSA | OSA Publishing
      Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Multiple scattering in turbid media inhibits optimal light focusing and thus limits the penetration depth in optical coherence tomography (OCT). However, the effects of multiple scattering in a turbid medium can be systematically controlled by shaping the incident wavefront. The authors utilize the reciprocity of Maxwell’s equations and finite-difference time-domain numerical analysis to investigate the ultimate performance bounds of wavefront shaping-OCT under ideal and realistic configurations and compare them with the conventional method. The results reveal that the optimized impinging wavefront significantly enhances the penetration depth of OCT.

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      Mentions: Konyang University Korea Advanced Institute of Science and Technology YongKeun Park

    24. Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Explore IEEE Xplore Ophthalmology
      Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Ophthalmic microsurgery is known to be a challenging operation, which requires very precise and dexterous manipulation. Image guided robot-assisted surgery (RAS) is a promising solution that brings significant improvements in outcomes and reduces the physical limitations of human surgeons. However, this technology must be further developed before it can be routinely used in clinics. One of the problems is the lack of proper calibration between the robotic manipulator and appropriate imaging device. In this work, we developed a flexible framework for hand-eye calibration of an ophthalmic robot with a microscope-integrated Optical Coherence Tomography (MI-OCT) without any markers. The proposed method ...

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      Mentions: Carl Zeiss Meditec Technical University of Munich
    25. See all articles

  2. Recent Articles From Around The Web

    1. Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants

      The purpose of this study is to develop a novel noninvasive bedside optical coherence tomography (OCT) imaging technique in newborn infants with HIE that improves our ability to assess the range of retinal effects from HIE and to diagnose and monitor treatments of HIE

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      Mentions: Duke University National Eye Institute University of Utah

    2. Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

      Explore Karger Publishers Pulmonology
      Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

      Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. Objective: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects of BT by OCT and compare these to the untreated right middle lobe (RML). Methods: Severe asthma patients were treated with BT (TASMA trial). During the third BT procedure, OCT ...

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      Mentions: Academic Medical Center at the University of Amsterdam Daniël M. de Bruin Jan D'hooge

    3. Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

      Explore Journals Neurology , Ophthalmology
      Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

      Maximizing extent of resection has been correlated with improved outcomes in a variety of pediatric and adult brain tumors. 1-11 While gross total resections are often achieved without the use of intraoperative adjuncts, difficulty in distinguishing tumor from normal brain can at times prevent the complete resection of brain tumors. Intraoperative imaging tools have increasingly been embraced with the goal of improving rates of gross total resection. In this review, we will discuss several currently used intraoperative imaging modalities, including intraoperative magnetic resonance imaging (iMRI), wide-field fluorescence, high-resolution fluorescence microscopy, and optical coherence tomography (OCT). 12-17 We will also discuss ...

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      Mentions: Stanford University Adam de la Zerda Orly Liba

    4. Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)

      Explore ScienceDirect Cardiology
      Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)

      Background Percutaneous coronary intervention (PCI) in complex bifurcation lesions is prone to suboptimal implantation results and is associated with increased risk of subsequent clinical events. Angiographic ambiguity is high during bifurcation stenting but it is unknown if procedural guidance by intravascular optical coherence tomography (OCT) improves clinical outcome. Methods and design OCTOBER is a randomized, investigator initiated, multi-center trial aimed to show superiority of OCT guided stent implantation compared to standard angiographic guided implantation in bifurcation lesions. The primary outcome measure is a two-year composite endpoint of cardiac death, target lesion myocardial infarction, and ischemia driven target lesion revascularization. The ...

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      Mentions: Tampere University of Technology VU University Amsterdam John A. Ormiston

    5. Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

      Explore ScienceDirect Ophthalmology
      Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

      Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo . Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis HRA + OCT. Histological analysis was performed using epoxy resin embedded tissue and transmission electron microscopy. Photomicrographs from the histologic sections were linearly scaled to correct for tissue shrinkage and correlated ...

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      Mentions: Texas A&M University Heidelberg Spectralis

    6. Using spectral-domain optical coherence tomography to evaluate the type and thickness of interdigitation zone band in adult Chinese

      Explore Nature Publishing Group Ophthalmology
      Using spectral-domain optical coherence tomography to evaluate the type and thickness of interdigitation zone band in adult Chinese

      To study types and thickness of interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of interdigitation zone band. There are two types of interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which ...

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      Mentions: Capital Medical University Tsinghua University

    7. Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

      Explore The JAMA Network Ophthalmology
      Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

      Importance Patients with birdshot chorioretinopathy (BSCR) can experience a delay in diagnosis owing to the challenges of identifying the condition prior to evolution of characteristic choroidal scars. An objective, noninvasive method for detecting early lesions in BSCR might have an effect on preventing vision loss in these patients. Objective To test the feasibility of swept-source optical coherence tomography angiography (SS-OCTA) in the detection of BSCR choroidal lesions and to use en face image analysis of choroidal layers to localize lesion depth. Design, Setting, and Participants Prospective, longitudinal, observational case series of 3 patients diagnosed as having BSCR at 1 of ...

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      Mentions: University of Washington Ruikang K. Wang University of Bern

    8. Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

      Explore BJO Online Ophthalmology
      Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

      Aims To compare the peripapillary vessel density (VD) measurements of high-density (HD) and non-HD optical coherence tomography angiography (OCTA) scans in normal and glaucoma eyes, and to evaluate the intrasession repeatability of VD measurements of HD scans. Methods In a cross-sectional study, 46 normal (33 subjects) and 89 glaucoma (64 patients) eyes underwent 3 HD and 1 non-HD optic nerve head OCTA scans in the same session. Agreement in VD measurements between HD and non-HD scans was assessed using Bland and Altman analysis. Repeatability of the VD measurements of HD scans was assessed using within-subject coefficient of repeatability (CRw) and ...

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      Mentions: UCSD University of Colorado Robert N. Weinreb

    9. Hand-held optical coherence tomography monitoring of submillimeter retinoblastoma treated with indocyanine green-enhanced transpupillary therapy

      Explore meajo.org Ophthalmology
      Hand-held optical coherence tomography monitoring of submillimeter retinoblastoma treated with indocyanine green-enhanced transpupillary therapy

      Over recent years, hand-held optical coherence tomography (HH-OCT) has become critical for retinoblastoma diagnosis and management. We report precise HH-OCT findings in a case of sub-millimeter retinoblastoma treated with foveal-sparing indocyanine green-enhanced transpupillary thermotherapy (ICG-TTT). A 2-month-old Caucasian female with bilateral Group B retinoblastoma showed two recurrent macular tumors in the right eye, demonstrating 88 μm and 37 μm of growth to 344 μm and 413 μm in thickness, respectively, on HH-OCT. Each was treated with additional intravenous chemotherapy and foveal-sparing ICG-TTT. Tumor regression to 154 μm and 224 μm was documented on HH-OCT and maintained on follow-up. HH-OCT is ...

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      Mentions: Thomas Jefferson University Carol L. Shields

    10. Method for analyzing an object using a combination of long and short coherence interferometry

      Explore uspto.gov Patents
      Method for analyzing an object using a combination of long and short coherence interferometry

      A method for high dynamic range and high accuracy interferometry measurements is described. The method uses a broadband light source for generating light, an interferometer, a phase shifting device, an imaging optical system and a detector array for collecting and measuring the reflected light from an object. The detected light is processed by a processor unit to obtain the object's surface.

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    11. Optical Coherence Tomography Reveals Sigmoidal Crystalline Lens Changes during Accommodation

      Explore MDPI Open Access Journals Platform Ophthalmology
      Optical Coherence Tomography Reveals Sigmoidal Crystalline Lens Changes during Accommodation

      This study aimed to quantify biometric modifications of the anterior segment (AS) during accommodation and to compare them against changes in both accommodative demand and response. Thirty adults, aged 18–25 years were rendered functionally emmetropic with contact lenses. AS optical coherence tomography (AS-OCT) images were captured along the 180° meridian (Visante, Zeiss Meditec, Jena, Germany) under stimulated accommodative demands (0–4 D). Images were analysed and lens thickness (LT) was measured, applying a refractive index correction of 1.00. Accommodative responses were also measured sequentially through a Badal optical system fitted to an autorefractor (Shin Nippon NVision-K 5001, Rexxam ...

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      Mentions: Carl Zeiss Meditec

    12. Quantitative retinal autofluorescence mapping with multimodal imaging technology

      Explore uspto.gov Ophthalmology , Patents
      Quantitative retinal autofluorescence mapping with multimodal imaging technology

      Imaging systems and methods of using the same are provided for monitoring the quantity of fluorescent pigment, for example lipofuscin, in the retinal pigment epithelium (RPE) layer of a retina in vivo. Various imaging modalities can be integrated into a single system and excited by a single broadband light source for the monitoring of the fluorescent pigment. The influence of varying optical properties found in the optical path of the pigment's auto-fluorescence between the RPE and an image receiver can be corrected.

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      Mentions: Shuliang Jiao University of Miami

    13. An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density

      Explore IOVS Journal
      An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density

      Purpose : To assess the relationship between the size of the foveal avascular zone (FAZ; area and perimeter) and vessel density (VD) at various retinal regions using optical coherence tomography angiography (OCTA) in patients with open-angle glaucoma (OAG). Methods : In this retrospective cross-sectional study, OAG eyes were grouped according to the presence/absence of central visual field (CVF) defects. A control group of normal eyes was also included. OCTA images were obtained from the optic nerve (4.5 × 4.5 mm 2 ) and macular (3 × 3 mm 2 ) area, in which VDs were measured in the circumpapilla, parafovea, and fovea regions ...

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      Mentions: University of Ulsan Michael S. Kook

    14. Localization of Paracentral Acute Middle Maculopathy Using Optical Coherence Tomography Angiography

      Explore Healio.com Ophthalmology
      Localization of Paracentral Acute Middle Maculopathy Using Optical Coherence Tomography Angiography

      Paracentral acute middle maculopathy (PAMM) refers to band-like hyperreflective lesions seen on spectral-domain optical coherence tomography, mostly confined to the inner nuclear layer. It has been previously demonstrated to involve the deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). A 29-year-old female presented with PAMM and was investigated using a new OCTA system that shows not just the superficial capillary plexus and DCP, but also the four vascular plexuses as previously demonstrated in histology. Using this system, involvement of the DCP was shown, but also of more superficial layers, including the intermediate capillary plexus

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    15. Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease

      Explore Healio.com Ophthalmology
      Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease

      The authors report a case of acute Vogt-Koyanagi-Harada syndrome with massively impaired perfusion in the Sattler's layer on optical coherence tomography angiography (OCTA). The hypoperfusion fully resolved during a period of 4 weeks and correlated well with hypofluorescent spots on indocyanine green angiography. This is the first time reduced perfusion in Sattler's layer has been observed on OCTA. This finding may aid further understanding of the pathology underlying VKH syndrome and indicates that evaluation of deeper choroidal layers like Sattler's layer may be of importance for disease monitoring and predicting prognosis in choroidal diseases.

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    Image Data Analyst, GlaxoSmithKline Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign Imaging Research Scientist, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign Feature Issue of Biomedical Optics Express: Progress in Multimodal En-Face Imaging Manuscript Deadline September 15, 2018 In vivo detection of UV-induced acute skin effects using optical coherence tomography Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging Thorlabs Releases New MEMS‐VCSEL Swept‐Wavelength Laser Sources Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients Spectroscopic characterization of Si/Mo thin-film stack at extreme ultraviolet range Group refractive index and group velocity dispersion measurement by complex master slave interferometry Masters of Science in Optical Coherence Tomography at the University of Kent Post-doctoral Research Fellow Position and 2 PhD Studentships in Ophthalmic Imaging at the Nicolaus Copernicus University, Torun, Poland

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