1. Feature Of The Week

    Industrial monuments and other artefacts of vanishing industries have to be preserved as cultural heritage. For example, in Germany next year the public subsidy for the mining industry will end and with this the active mining will end as well. The Deutsches Bergbau-Museum in Bochum as one of the largest of its kind and as a research institution of the Leibnitz association is committed to preserve the cultural heritage of the mining industry. Thus it is facing the huge task to conserve a lot of mining industry objects in their actual authentic appearance, ranging from small tools like hammers to huge outdoor facilities like e.g. a blast furnace. Common non-transparent protective coatings are not applicable, because the historical character of these cultural heritages must be maintained.

    Therefore alternative transparent coatings have to be evaluated with respect to their functionality and durability. For the in-situ monitoring of real historical artefacts the tools need to be non-destructive and easy to use.

    The current standard method to evaluate anti-corrosion coatings for metallic substrates is Electrochemical Impedance Spectroscopy. Here a probe consisting of an electrolyte with two electrodes is contacted with the sample. An alternating voltage with a swept frequency is applied and the current is measured. Information about the protection efficiency of the coating and about the underlying corrosion process can be derived indirectly by fitting the curves with equivalent electrical circuit models of the sample and the total setup. But this procedure is rather complex, bears the risk of ambiguity and of course does not provide a direct visual impression. Furthermore quantitative values e.g. for the actual layer thickness are not provided and the measurement procedure itself is very time consuming.

    A method to directly measure the thickness of a non-magnetic coating on a magnetic substrate is the magnetic induction technique. A magnetic probe is contacted with the sample surface and an alternating magnetic field is applied. With a second coil the retarded magnetic flux is measured. The induced voltage correlates with distance of the probe to the metallic substrates that is with the thickness of the coating layer. The coating thicknesses can be measured with an accuracy of about 1 µm. The lateral resolution depends on the probe size and is about 1 mm2. But this technique fails on pre-corroded samples which is a drawback for our work, since we are dealing exactly with that kind of samples.

    In this work we present optical coherence tomography (OCT) as a new diagnostic tool for the evaluation of transparent anti-corrosion coatings for the conservation of industrial heritage.

    Since OCT provides three dimensional cross-sectional images the actual coating layer thickness can be determined. Moreover, by introducing a scattering layer and measuring its thickness a metric for the differentiation between metal and corrosion as underlying substrate can be derived.

    First the accuracy of our coating thickness measurements was validated by comparing the OCT results with magnetic inductive measurements on six samples with bare metal and varying coating layer thicknesses. Additionally a customized sectioned sample was fabricated. With this sample, we demonstrated that OCT is capable of monitoring the coating layer thickness even for corroded areas, and that regions with metal or corrosion can be separated. Moreover, a standard sample with randomly distributed corrosion was investigated to show, that OCT is also capable to monitor real world samples with no defined boundaries.

    With this work, we have illustrated the benefit of employing optical coherence tomography for the non-destructive investigation of transparent protection coatings. To our knowledge, no other non-destructive modality has provided comparable information. Moreover, by using OCT, the differentiation between metal and corroded material becomes possible with µm resolution in the lateral dimension.

    Acknowledgments: This work was financially supported by the Stiftung Rheinisch-Westfälischer Technischer Überwachungsverein (RWTÜV, Essen, Germany) (Project Numbers: S189/10024/2015, S189/10025/2015). We acknowledge support by the DFG Open Access Publication Funds of the Ruhr-Universität Bochum (Bochum, Germany).

    For more information see recent Article. Courtesy Martin Hofmann from Ruhr-University Bochum. To share this article click Here.

  2. Featured Articles

    1. Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Explore Circulation Cardiology
      Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Background —Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. Methods —Consecutive patients presenting with ST were prospectively enrolled in a registry using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT. Clinical data were collected according to a standardized protocol. OCT acquisitions were analyzed at a core laboratory. Dominant and contributing findings were adjudicated by an imaging ...

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      Mentions: Giulio Guagliumi Fernando Alfonso Kenichi Komukai

    2. Viewing a Weld Seam in 360°: New Scan Solution Utilizes OCT Technology to Coaxially Track and Inspect Seams

      Explore Optical Coherence Tomography News NDE/NDT
      Viewing a Weld Seam in 360°: New Scan Solution Utilizes OCT Technology to Coaxially Track and Inspect Seams

      At the Laser World of Photonics tradeshow in Munich, Germany, Blackbird Robotersysteme GmbH (acknowledged remote welding expert and SCANLAB GmbH associate company) will present an entirely new scan solution prototype with integrated distance sensor. Based on optical coherence tomography (OCT), the system detects and measures 3D laser weld seam topographies in high resolution. This is particularly advantageous for industrial system integrators and users looking to secure process safety and comprehensive quality management without a separate monitoring solution. In healthcare OCT has proven itself as an examination technique for opththamology, skin analysis, cancer diagnosis and more. For patients, this optical measurement ...

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      Mentions: Blackbird Robotersysteme GmbH SCANLAB GmbH

    3. Beckman Foundation Names Dr. James G. Fujimoto of the Massachusetts Institute of Technology as 2017 Beckman-Argyros Vision Research Award Winner

      Explore prweb.com
      Beckman Foundation Names Dr. James G. Fujimoto of the Massachusetts Institute of Technology as 2017 Beckman-Argyros Vision Research Award Winner

      The Arnold and Mabel Beckman Foundation has announced James G. Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology, as its 2017 Beckman-Argyros Vision Research Award winner. Presented annually, the award recognizes an individual who has made and is continuing to make significant transformative breakthroughs in vision research; particularly through the development of an innovative technology or fundamental scientific breakthrough that has been applied to, aided and/or improved the vision sciences. Dr. Fujimoto and MIT will receive $100,000 and $400,000, respectively, to further advance the application of ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto

    4. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Explore OSA | OSA Publishing Tunable Sources
      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system’s performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ...

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      Mentions: Columbia University Christine Hendon

    5. Two Engineering Openings at Startup Company Opticent Health

      Explore Optical Coherence Tomography News Jobs & Studentships
      Two Engineering Openings at Startup Company Opticent Health

      Opticent, Inc. (Opticent Health – www.opticenthealth.com) is a start-up company commercializing an in-house developed patent portfolio related to visible-light optical coherence tomography (OCT) targeting the ophthalmic market. Opticent Health’s core technologies were developed at Northwestern University. Since its founding, Opticent Health has experienced rapid market adoption of its OCT instruments and rapid commercial expansion. Opticent Health is located in Evanston IL, part of the greater Chicago metropolitan area. The company’s management team, with guidance from its prominent advisory board, is expanding its engineering staff and seeks highly qualified personnel for the following two positions: 1. Ph.D ...

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      Mentions: Northwestern University Hao F. Zhang Opticent Health

    6. Complex decorrelation averaging in optical coherence tomography: a way to reduce the effect of multiple scattering and improve image contrast in a dynamic scattering medium

      Explore OSA | OSA Publishing
      Complex decorrelation averaging in optical coherence tomography: a way to reduce the effect of multiple scattering and improve image contrast in a dynamic scattering medium

      We demonstrate that complex decorrelation averaging can reduce the effect of multiple scattering and improve optical coherence tomography (OCT) imaging contrast. Complex decorrelation averaging calculates the product of an A-scan and the complex conjugate of a subsequent A-scan. The resultant signal is the product of the amplitudes and the phase difference. All these resulting complex signals at a particular location are then averaged. We take advantage of the fact that complex averaging, in contrast to conventional magnitude averaging, is sensitive to phase decorrelation. Sample motion that increases signal phase variance results in lower signal magnitude after complex averaging. Such motion ...

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      Mentions: Andrew M. Rollins Case Western Reserve University Lars Thrane

    7. Michelson Diagnostics Secures CPT codes for Optical Coherence Tomography Imaging of Skin

      Explore Optical Coherence Tomography News Dermatology , Other Business News
      Michelson Diagnostics Secures CPT codes for Optical Coherence Tomography Imaging of Skin

      Michelson Diagnostics announces that the American Medical Association (AMA) CPT Editorial Panel recently approved two new Category III CPT codes for Optical Coherence Tomography (OCT) imaging of skin. Code 0470T is for OCT microstructural and morphological imaging of skin, image acquisition, interpretation and report for a first lesion; code 0471T is the same for each additional lesion. The new Category III codes, which are for emerging technologies, services, and procedures, are effective July 1, 2017. Michelson Diagnostics pursued approval of this code at the AMA CPT Panel meeting in October 2017, receiving support from the American Academy of Dermatology. “Obtaining ...

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      Mentions: Michelson Diagnostics Jon Holmes FDA

    8. Murine chronic lymph node window for longitudinal intravital lymph node imaging

      Explore Nature Publishing Group
      Murine chronic lymph node window for longitudinal intravital lymph node imaging

      Chronic imaging windows in mice have been developed to allow intravital microscopy of many different organs and have proven to be of paramount importance in advancing our knowledge of normal and disease processes. A model system that allows long-term intravital imaging of lymph nodes would facilitate the study of cell behavior in lymph nodes during the generation of immune responses in a variety of disease settings and during the formation of metastatic lesions in cancer-bearing mice. We describe a chronic lymph node window (CLNW) surgical preparation that allows intravital imaging of the inguinal lymph node in mice. The CLNW is ...

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      Mentions: Massachusetts General Hospital Harvard University Sungkyunkwan University

    9. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Explore SPIE | Journal Gastroenterology
      Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett’s esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University

    10. Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation

      Explore OSA | OSA Publishing
      Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation

      Retinal vascular occlusive diseases represent a major form of vision loss worldwide. Rodent models of these diseases have traditionally relied upon a slit-lamp biomicroscope to help visualize the fundus and subsequently aid delivery of high-power laser shots to a target vessel. Here we describe a multimodal imaging system that can produce, image, and monitor retinal vascular occlusions in rodents. The system combines a spectral-domain optical coherence tomography system for cross-sectional structural imaging and three-dimensional angiography, and a fluorescence scanning laser ophthalmoscope for Rose Bengal monitoring and high-power laser delivery to a target vessel. This multimodal system facilitates the precise production ...

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      Mentions: Northwestern University Hao F. Zhang

    12. Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

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      Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

      Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl − ) transport is one such mechanism that contributes to this disorder and can be acquired secondary to environmental perturbations, such as hypoxia at the tissue surface. The objective of this study was to assess the technological feasibility of the novel micro-optical coherence tomography (μOCT) imaging technique for investigating acquired MCC defects in cultured human sinonasal epithelial (HSNE) cells. Methods Primary HSNE cell cultures were subjected to a 1% oxygen environment for 12 hours to induce acquired ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    13. Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?

      Explore MDPI Open Access Journals Platform
      Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?

      Optical Coherence Tomography Angiography (OCTA) refers to a powerful class of OCT scanning protocols and algorithms that selectively enhance the imaging of blood vessel lumens, based mainly on the motion and scattering of red blood cells (RBCs). Though OCTA is widely used in clinical and basic science applications for visualization of perfused blood vessels, OCTA is still primarily a qualitative tool. However, more quantitative hemodynamic information would better delineate disease mechanisms, and potentially improve the sensitivity for detecting early stages of disease. Here, we take a broader view of OCTA in the context of microvascular hemodynamics and light scattering. Paying ...

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      Mentions: Vivek J. Srinivasan UC Davis

    14. Tunable laser array system

      Explore uspto.gov Patents , Tunable Sources
      Tunable laser array system

      A system for swept source optical coherence tomography, the system including a light source emitting multiplexed wavelength-swept radiation over a total wavelength range, the light source including N wavelength-swept vertical cavity lasers (VCL) emitting N tunable VCL outputs having N wavelength trajectories, a combiner for combining the N tunable VCL optical outputs into a common optical path to create the multiplexed wavelength-swept radiation, a splitter for splitting the multiplexed wavelength-swept radiation to a sample and a reference path, an optical detector for detecting an interference signal created by an optical interference between a reflection from the sample and light traversing ...

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      Mentions: Thorlabs Alex E. Cable Benjamin M. Potsaid

    15. Automatic classification of atherosclerotic tissue in intravascular optical coherence tomography images

      Explore OSA | OSA Publishing Cardiology
      Automatic classification of atherosclerotic tissue in intravascular optical coherence tomography images

      Intravascular optical coherence tomography (IVOCT) has been successfully utilized for in vivo diagnostics of coronary plaques. However, classification of atherosclerotic tissues is mainly performed manually by experienced experts, which is time-consuming and subjective. To overcome these limitations, an automatic method of segmentation and classification of IVOCT images is developed in this paper. The method is capable of detecting the plaque contour between the fibrous tissues and other components. Subsequently, the method classifies the tissues based on their texture features described by Fourier transform and discrete wavelet transform. The experimental results of 103 images show that an overall classification accuracy of ...

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    16. Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos

      Explore Nature Publishing Group Developmental Biology , Microscopy
      Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos

      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers’ ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging techniques and provides unique access to fundamental aspects of early embryonic development, without the requirement for sample pre-processing or labeling. In the present paper, we utilized the internal motion of ...

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      Mentions: Maciej Wojtkowski Nicolaus Copernicus University Maciej Szkulmowski

    17. Compact Imaging Teams with SRI International for Dynamic Biometrics Development under IARPA Odin Program

      Explore Optical Coherence Tomography News Other Non-Medical , Funding
      Compact Imaging Teams with SRI International for Dynamic Biometrics Development under IARPA Odin Program

      Compact Imaging, Inc. (CI) today announced that SRI International has selected CI’s non-invasive depth scanning sensor, MRO™, as a critical component in the development of “dynamic biometrics” for improved detection of attempts to evade or deceive biometric security systems, such as fingerprint scanners. The development is being performed under a multi-year contract awarded to SRI as part of IARPA’s (Intelligence Advanced Research Projects Activity, National Intelligence Directorate) Odin Program. The goal of the Odin Program is to develop advanced technologies to detect “presentation attacks,” as attempts to deceive biometric security systems are often called. Conventional biometrics, such as ...

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      Mentions: Don Bogue Compact Imaging, Inc

    18. 16  MHz wavelength-swept and wavelength-stepped laser architectures based on stretched-pulse active mode locking with a single continuously chirped fiber Bragg grating

      Explore OSA | OSA Publishing Tunable Sources
      16  MHz wavelength-swept and wavelength-stepped laser architectures based on stretched-pulse active mode locking with a single continuously chirped fiber Bragg grating

      We demonstrate a novel high-speed and broadband laser architecture based on stretched pulse active mode locking that provides a wavelength-swept and wavelength-stepped output. The laser utilizes a single intracavity 8.3 meter chirped fiber Bragg grating to generate positive and negative dispersion, and can be operated with or without an intracavity fixed Fabry–Perot etalon to generate wavelength-swept and wavelength-stepped (frequency comb) outputs, respectively. Using a four-path delay line at the output, we achieved 16.3 MHz repetition rates and a 62 nm lasing bandwidth centered at 1550 nm. Single-sided double-pass coherence lengths of 1.25 mm for the wavelength-swept ...

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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University
    19. See all articles

  3. Recent Articles From Around The Web

    1. Feature Of The Week 07/24/2017: Spectral Domain Optical Coherence Tomography for Non-Destructive Testing of Protection Coatings on Metal Substrates

      Explore Optical Coherence Tomography News Art , NDE/NDT
      Feature Of The Week 07/24/2017: Spectral Domain Optical Coherence Tomography for Non-Destructive Testing of Protection Coatings on Metal Substrates

      Industrial monuments and other artefacts of vanishing industries have to be preserved as cultural heritage. For example, in Germany next year the public subsidy for the mining industry will end and with this the active mining will end as well. The Deutsches Bergbau-Museum in Bochum as one of the largest of its kind and as a research institution of the Leibnitz association is committed to preserve the cultural heritage of the mining industry. Thus it is facing the huge task to conserve a lot of mining industry objects in their actual authentic appearance, ranging from small tools like hammers to ...

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    2. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      Explore ScienceDirect Dermatology , Other Non-Medical
      New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 year old female when under normal and shear loading. Measurements were taken during static, and for the first time, dynamic phases. It was observed that the number of ridges in ...

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    3. Morphometric parameters of the optic disk in normal and glaucomatous eyes based on time-domain optical coherence tomography image analysis

      Explore ScienceDirect Ophthalmology
      Morphometric parameters of the optic disk in normal and glaucomatous eyes based on time-domain optical coherence tomography image analysis

      Background and objective Assessment of optic disk morphology is essential in diagnosis and management of visual impairment. The aim of this study was to evaluate associations between optic disk morphometric parameters, i.e., size and shape, and age, gender, and ocular axial length in normal and glaucomatous eyes based on time-domain optical coherence tomography image analysis. Materials and methods It was a case–control study of 998 normal and 394 eyes with primary open angle glaucoma that underwent ophthalmological investigation and time-domain optical coherence topography scanning. Areas and shapes of the disk, cup, and neuroretinal rim were analyzed. Results The ...

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    4. Determination of Coefficient of Thermal Expansion in High Power GaN-Based Light-Emitting Diodes via Optical Coherent Tomography

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      Determination of Coefficient of Thermal Expansion in High Power GaN-Based Light-Emitting Diodes via Optical Coherent Tomography

      One of the most challenging issues when operating a high-power light-emitting diode (LED) is to conduct appropriate packaging materials for the reliable thermal management of the entire device. Generally, the considerable amount of heat produced around the junction area of the LED would transfers to the entire device, and causes thermal expansion in the packaging material. It induces strain inevitably, and hinders the output performances and possible applications of high-power LEDs. The coefficient of thermal expansion (CTE) is a physical quantity that indicates the expansion to which value a material will be upon heating. Therefore, as far as an advancement ...

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      Mentions: Meng-Tsan Tsai Ya-Ju Lee

    5. Anterior Chamber Angle and Trabecular Meshwork Measurements Made by Fourier-domain Optical Coherence Tomography in Healthy White Children

      Explore LWW Online Ophthalmology
      Anterior Chamber Angle and Trabecular Meshwork Measurements Made by Fourier-domain Optical Coherence Tomography in Healthy White Children

      Purpose: To obtain anterior chamber angle and trabecular meshwork (TM) measurements by Fourier-domain optical coherence tomography (FD-OCT) in a population of healthy white children. Materials and Methods: This was a cross-sectional study examining 409 right eyes of 409 children. Trabecular-iris angle (TIA) and TM length and area were measured by FD-OCT (RTVue 100) in the nasal and temporal quadrants to analyze correlations between angle or TM measurements and age, sex, and refractive error. Results: Mean participant age was 10.5+/-3.4 years (range, 3 to 18 y); 51% were boys. Mean spherical error was 0.56+/-2.4 D ...

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      Mentions: Optovue RTVue-100

    6. Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review

      Explore TVST Journal Ophthalmology
      Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review

      Purpose : To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). Methods : Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established reference standards and risk of bias. Results : Thirty five studies reporting computer-aided diagnosis (CAD) tools for qualitative analysis or algorithms for quantitative analysis were identified. Compared with manual assessment in ...

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      Mentions: University of Bonn Frank G. Holz Steffen Schmitz-Valckenberg

    7. Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe

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      Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe

      Biomedical materials have different optical properties (e.g. absorption) for different wavelengths. Therefore, probing biomedical materials with multiple wavelengths not only can get in-depth understanding of the detected biomedical materials but also can differentiate the detected biomedical materials. To achieve this purpose, in this conference paper, we present our initial results of building up a portable multiple-wavelength biomedical sensing system. At this initial phase, we assembled this kind of system with multiple wavelengths of light sources and photodetectors and preliminarily tested the absorbance of the glucose solutions with different concentrations. The result shows good linearity of the absorbance of the ...

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      Mentions: National Taiwan University Meng-Tsan Tsai Chang Gung University

    8. Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole

      Explore SPIE | Journal Ophthalmology
      Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole

      Cystoid macular edema (CME) and macular hole (MH) are the leading causes for visual loss in retinal diseases. The volume of the CMEs can be an accurate predictor for visual prognosis. This paper presents an automatic method to segment the CMEs from the abnormal retina with coexistence of MH in three-dimensional-optical coherence tomography images. The proposed framework consists of preprocessing and CMEs segmentation. The preprocessing part includes denoising, intraretinal layers segmentation and flattening, and MH and vessel silhouettes exclusion. In the CMEs segmentation, a three-step strategy is applied. First, an AdaBoost classifier trained with 57 features is employed to generate ...

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    9. Space Flight–Associated Neuro-ocular Syndrome

      Explore The JAMA Network Neurology , Ophthalmology
      Space Flight–Associated Neuro-ocular Syndrome

      New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight–associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts ...

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      Mentions: Cornell University Baylor College of Medicine University of Texas Medical Branch

    10. Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease

      Explore LWW Online Cardiology
      Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease

      Introduction: Cardiovascular mortality of patients with combined peripheral arterial disease (PAD) and coronary artery disease (CAD) is twice as high as that in those with either disease alone. It is known that patients with PAD undergoing percutaneous coronary intervention have a higher incidence of adverse cardiac events such as myocardial infarction or target vessel revascularization. Objective: In this study, we compared the detailed characteristics of culprit and nonculprit plaques between patients with and those without PAD using optical coherence tomography. Patients and methods: We performed propensity score matching using the following variables: (i) age; (ii) sex; (iii) clinical presentation; (iv ...

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    11. Comparison of macular choroidal thickness in patients with pseudoexfoliation syndrome to normal control subjects with enhanced-depth SD-OCT imaging

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      Purpose To test the hypothesis that macular choroidal thickness is lower in patients with pseudoexfoliation syndrome (PXS) as compared to healthy control subjects. Methods In this cross-sectional, observational study, 38 non-glaucomatous PXS subjects and 37 healthy volunteers were enrolled in a tertiary care Glaucoma Clinic. The macular region was scanned with the enhanced depth imaging (EDI) protocol of a spectral domain optical coherence tomography (SD-OCT) device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany). Macular choroidal thickness and volumes were compared in nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) layout profile across the central 3.45 mm zone after ...

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      Mentions: Capital Medical University

    14. Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and in vivo confocal microscopy

      Explore ScienceDirect Ophthalmology
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      Purpose The study aimed to evaluate clinical and morphological changes in the limbal palisades of Vogt (POV) at different stages of aniridia-associated keratopathy (AAK) and to assess possible utility of anterior segment optical coherence tomography (AS-OCT) for the visualization of limbal progenitor structures as it correlates to laser scanning confocal microscopy (LSCM) data. Methods The study involved 32 patients (59 eyes) with congenital aniridia. AAK stage was defined based on biomicroscopy. Assessment of limbal zone and detection of POVs in identical areas was performed by LSCM (HRT3) and AS-OCT (RTVue XR Avanti) using 3D Cornea (En Face mode) and Cornea ...

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      Explore SPIE | Journal Developmental Biology , Neurology
      Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI

      An automated massive histology setup combined with an optical coherence tomography (OCT) microscope was used to image a total of n = 5 n=5 whole mouse brains. Each acquisition generated a dataset of thousands of OCT volumetric tiles at a sampling resolution of 4.9 × 4.9 × 6.5    μ m 4.9×4.9×6.5  μm . This paper describes techniques for reconstruction and segmentation of the sliced brains. In addition to the measured OCT optical reflectivity, a single scattering photon model was used to compute the attenuation coefficients within each tissue slice. Average mouse brain templates were generated for ...

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      Mentions: Polytechnique Montreal Frédéric Lesage
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