1. Recent Articles From Around The Web

    1. The additional diagnostic value of optical coherence tomography in clinically diagnosed basal cell carcinomas undergoing direct surgical excision

      The additional diagnostic value of optical coherence tomography in clinically diagnosed basal cell carcinomas undergoing direct surgical excision

      Clinical examination appears to be very sensitive for diagnosing BCC (90%), but the specificity is reported to be low (28.6-48.9%).(1, 2) Additional use of dermoscopy can increase specificity to 54.3-55.6% compared to clinical examination alone.(1, 2) With use of optical coherence tomography (OCT), a non-invasive diagnostic method, in addition to clinical and dermoscopic examination, it is possible to further increase the specificity to 76% at a sensitivity of 95%.(1, 3, 4) These results apply to a population of patients with a clinical suspicion of BCC who had an indication for biopsy (e.g ...

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    2. Stabilizing the phase of swept-source optical coherence tomography by a wrapped Gaussian mixture model

      Stabilizing the phase of swept-source optical coherence tomography by a wrapped Gaussian mixture model

      The phase of an optical coherence tomography (OCT) signal carries critical information about particle micro-displacements. However, swept-source OCT (SSOCT) suffers from phase instability problems due to trigger jitters from the swept source. In this Letter, a wrapped Gaussian mixture model (WGMM) is proposed to stabilize the phase of SSOCT systems. A closed-form iteration solution of the WGMM is derived using the expectation-maximization algorithm. Necessary approximations are made for real-time graphic processing unit implementation. The performance of the proposed method is demonstrated through ex vivo, in vivo, and flow phantom experiments. The results show the robustness of the method in different ...

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    3. Unsaturated fatty acid salts remove biofilms on dentures

      Unsaturated fatty acid salts remove biofilms on dentures

      Candidiasis-causing Candida sp. forms biofilms with various oral bacteria in the dentures of the elderly, making it harder to kill and remove the microorganism due to the extracellular polymeric substances. We found that biofilms on dentures can effectively be removed by immersion in an unsaturated fatty acid salt solution. Using optical coherence tomography to observe the progression of biofilm removal by the fatty acid salt solution, we were able to determine that the removal was accompanied by the production of gaps at the interface between the biofilm and denture resin. Furthermore, microstructural electron microscopy observations and time-of-flight secondary ion mass ...

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    4. Repeatability and inter-observer variation of choroidal thickness measurements using swept-source optical coherence tomography in myopic danish children aged 6–14 years

      Repeatability and inter-observer variation of choroidal thickness measurements using swept-source optical coherence tomography in myopic danish children aged 6–14 years

      Purpose: To estimate repeatability and inter-observer variation of choroidal thickness measurements in myopic Danish children aged 7-14 years using swept-source optical coherence tomography (SS-OCT). Methods: Thirty-nine children were enrolled. Optical correction was single-vision spectacles (SVS) or orthokeratology lenses (OKL). Three repeated 7 × 7 mm 3-dimensional SS-OCT macula scans and three repeated 9 mm SS-OCT line scans were collected for each child using a DRI OCT Triton. Choroidal thickness was measured using three different methods: line scan method 1 (LM1), line scan method 2 (LM2) and 3D macula scan method (3DM). Segmentation was adjusted if needed. Coefficients of repeatability (CR) and ...

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    5. Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery.

      Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery.

      Duke University Receives a 2021 NIH Grant for $743,426 for Intraoperative OCT Guidance of Intraocular Surgery. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is a resubmission application for a Bioengineering Research Partnership (BRP) which brings together a highly collaborative and experienced team of engineers and ophthalmic surgeons to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon’s current stereo microscopic view of ocular structures by continuing to integrate optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice ...

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    6. Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives a 2021 NIH Grant for $381,543 for Noninvasive Assessment of the Cornea by Diffusion OCT. The principal investigator is Andrew Rollins Below is a summary of the proposed work. Keratoconus is a degenerative disease of the cornea that is a major cause of reduced vision-related quality of life in the United States, often leading to corneal transplantation. Ectasia after refractive surgery is a vision-threatening complication that can occur in apparently low-risk patients despite current screening technology. The biomechanical properties of the cornea play a central role in these diseases, but diagnostics are still rooted ...

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    7. Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Stevens Institute of Technology Receives NIH Grant for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models

      Stevens Institute of Technology Receives a 2021 NIH Grant for $182,953 for In Vivo Imaging Platform for Ectopic Pregnancy Research in Mouse Models. The principal investigator is Shang Wang. Below is a summary of the proposed work. Tubal ectopic pregnancy (tEP) is a life-threatening reproductive disorder affecting nearly 2% of pregnancies in developed countries. The etiology of tEP is far from resolved, leaving no way to design preventive measures and few strategies for early diagnosis. Investigating how a tEP forms and develops has been extremely difficult. Because it is unethical to access human oviduct (fallopian tube) during healthy pregnancies ...

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    8. Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2021 NIH Grant for $436,277 for Novel Optical Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. Below is a summary of the proposed work. This proposal is a renewal of an ongoing collaborative program among investigators at the Massachusetts Institute of Technology (MIT) and New England Eye Center (NEEC). The program focuses on the development of optical coherence tomography (OCT) technology and its application to investigate structural alterations and blood flow impairment in age-related macular degeneration (AMD). Aim 1. Next Generation OCT Technology for Imaging Structure and Blood Flow in ...

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    9. Case Western University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western University Receives a 2021 NIH Grant for $484,748 for Computer Assisted Coronary Artery Stent Interventions. The principal investigator is David Wilson. Below is a summary of the proposed work Computer assisted coronary artery stent interventions Summary When treating highly calcified coronary artery lesions with stents, interventional cardiologists, with limited information, make stressful treatment decisions, which can lead to inadequate stent deployment and poor outcomes, or even rare calamitous events. When calcification is present, a cardiologist must choose to use a normal sized angioplasty balloon; a larger angioplasty balloon with increasingly high, prolonged pressures to fracture the calcification ...

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    10. Methods and system for imaging an inner limiting membrane using a stain

      Methods and system for imaging an inner limiting membrane using a stain

      Systems and methods for imaging tissue are described. Particularly, systems and methods of imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of a patient's eye are disclosed. Imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex may include applying a stain to the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of the patient's eye, causing the stain to produce fluorescent light having a wavelength within a near-infrared range, capturing the fluorescent light, and producing an Optical Coherence Tomography (OCT) image of the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex ...

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    11. Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters

      Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters

      A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

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      Mentions: Avinger
    12. Single-ended probing through a multimode fiber having distributed reflectors

      Single-ended probing through a multimode fiber having distributed reflectors

      An optical frequency-domain reflectometer (OFDR) capable of estimating the transfer matrix of a multimode optical fiber using mode-selective measurements performed from a single end of the fiber. In an example embodiment, the multimode optical fiber includes distributed reflectors designed to generate relatively strong light reflections along the length of the fiber at a desired spatial resolution.

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    13. Higher-Order Core-Like Modes in Double-Clad Fiber Contribute to Multipath Artifacts in Optical Coherence Tomography

      Higher-Order Core-Like Modes in Double-Clad Fiber Contribute to Multipath Artifacts in Optical Coherence Tomography

      Double-clad fiber (DCF) has enabled the combination of endoscopic optical coherence tomography (OCT) with secondary optical modalities. While DCF offers an additional optical channel, it is widely understood that its use reduces the quality of OCT owing to the introduction of multipath artifacts. We show here that an unexpected higher-order mode (HOM) with its energy confined to the DCF core can contribute to these artifacts. The existence of this HOM is confirmed using the spatially and spectrally (S2) resolved imaging method. The group delay difference of the HOM is shown to be consistent with the delay of the diffuse ghost ...

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    14. Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography

      Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography

      Purpose To describe structural changes in corneal epithelium using anterior segment optical coherence tomography (AS-OCT) in two relapsed and refractory multiple myeloma (RRMM) patients with bilateral belantamab-associated superficial keratopathy (BASK). Observations: case 1 A 56-year-old male who was diagnosed with RRMM and initiated on belantamab mafodotin, presented on day 42 (three weeks after the second infusion) with decreased pinhole visual acuity from 20/20 and 20/25 to 20/70 and 20/50 in the right eye and left eye, respectively. Slit-lamp examination revealed moderate superficial keratopathy with microcystic-like epithelial changes (MECs) in the paracentral cornea in both eyes. AS-OCT ...

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    15. Automated identification of SD-optical coherence tomography derived macular diseases by combining 3D-block-matching and deep learning techniques

      Automated identification of SD-optical coherence tomography derived macular diseases by combining 3D-block-matching and deep learning techniques

      This paper reveals an automatic approach for macular diagnostic by the use of Optical Coherence Tomography (OCT) in the evaluation process. At preliminary behaviour levels, the evaluation of macular zone in OCT scan is characterised by an error prone task, related to the experience and the attention of ophthalmologists. Thus, different techniques of OCT-image analysis help the option of obtaining a consistent and independent diagnosis to identify macular degeneration behaviour. In this work, we report an automated approach based on a combined filtering and classification strategy. The presented method is validated on a real integrated diabetic oedema macular (DME) and ...

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    1. (5 articles) National Institutes of Health
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    Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography Optical Coherence Tomography for Neurovascular Disorders Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography Postdoctoral Research Associate – Optical Coherence Tomography at the University of Wisconsin-Madison Perimeter Medical Imaging AI Announces Important Milestone with Commercial-Scale Manufacturing of Perimeter S-Series OCT Now Underway Research Associate in Biophotonics at University of Sheffield Postdoctoral Research Associate GlaxoSmithKline Center for Optical Molecular Imaging Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Time-resolved spectral-domain optical coherence tomography with CMOS SPAD sensors Notal Vision raises up to $60 million to support development of its Home OCT technology and commercial growth of its ForeseeHome AMD Monitoring Program Tesseract Health Closes Oversubscribed $80 Million Series B Financing AI spots neurons better than human experts
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu