1. Recent Articles From Around The Web

    1. Ageing and glaucoma progression of the retinal nerve fibre layer using spectral‐domain optical coherence tomography analysis

      Ageing and glaucoma progression of the retinal nerve fibre layer using spectral‐domain optical coherence tomography analysis

      Purpose To compare the effects of ageing and glaucoma progression on the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and to evaluate the performance of a set of optical coherence tomography (OCT) progression analyses. Methods The cpRNFL was measured twice by OCT at each of two visits made 10 years apart in 69 healthy individuals and 49 glaucoma patients. Both visits also included Humphrey 24‐2 SITA standard testing. The change in cpRNFL thickness was analysed by linear regression, and a sub‐analysis was performed on glaucoma patients with a perimetric mean deviation better than −10 dB at ...

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    2. Automated measurement of the foveal avascular zone in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography

      Automated measurement of the foveal avascular zone in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography

      PURPOSE: To develop and evaluate an automated method to measure the foveal avascular zone (FAZ) area in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography (HS-OCTA). This method is referred to as the modified Kanno-Saitama macro (mKSM). METHODS: This cross-sectional study included 29 eyes of 25 healthy volunteers who underwent HS-OCTA at the macular area twice at the same time. Regardless of the quality of the images, all of them were included. Macular data on the superficial vascular plexus, intermediate capillary plexus and deep capillary plexus were processed by mKSM. The FAZ area was measured twice automatically using the ...

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    3. Vasculature of a minipig eye (microCT Group, Institute of Anatomy, University of Bern)

      Vasculature of a minipig eye (microCT Group, Institute of Anatomy, University of Bern)

      MicroangioCT of a minipig eye (collaboration with Vetsuisse Faculty, University of Zurich and OCTlab Research Laboratory, Department of Ophthalmology, University of Basel). Contrast agent used: µAngiofil (Fumedica AG, Switzerland). Scanner: desktop microCT-scanner Skyscan 1172 (Bruker microCT, Belgium). Isotrpic voxel size: 6.56µm.

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    4. OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D

      OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D

      Scientists from Stevens Institute of Technology and Baylor College of Medicine used 4D optical coherence tomography (OCT) to study the pumping mechanism underlying the developing mammalian heart. 4D OCT allowed them to investigate the functional relation between blood flow and heart wall dynamics within different regions of the embryonic heart at a level of detail not currently accessible by other methods. 4D OCT could potentially enable scientists to assess cardiac pumping over embryonic development as the heart tube remodels, which could reveal functional changes during early cardiogenesis that lead to congenital heart defects. The researchers used 4D OCT to obtain ...

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    5. Prevalence and quantitative assessment of macrophages in coronary plaques

      Prevalence and quantitative assessment of macrophages in coronary plaques

      Although optical coherence tomography (OCT) proved to be able to identify macrophage clusters, there are no available data on the possibility to obtain reproducible measurements of their circumferential extension and location. The purpose of the present post-hoc analysis of the CLIMA study was to revise the clinical and demographic variables of patients having coronary plaques with macrophages and to investigate the reproducibility of their quantitative assessment. A total of 577 patients out of 1003 undergoing OCT showed macrophage accumulation. Three groups were identified; group 1 (426 patients) without macrophages, group 2 (296) patients with low macrophage content (less than median ...

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    6. Spectrometer calibration with reduced dispersion for optical coherence tomography

      Spectrometer calibration with reduced dispersion for optical coherence tomography

      A wavelength calibration method is proposed for Fourier domain optical coherence tomography. In the present study, the wavelength remapping procedure is based on the spectral phase function determined by the calibration signal. To accomplish high accuracy feature for wavelength calibration, a common-path interferometer is employed. Two autocorrelation interferograms generated from the common-path interferometer are utilized as the calibration signals. The advantage of the interferometer proposed here is that the accurate optical path difference of the calibration signals could be acquired easily. The wavelength distribution in the spectrometer was deduced with the phase signal. The approach was compared to a wavelength-determined ...

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    7. Influence of sleep quality on macula and retinal nerve fiber layer in caucasian healthy adolescents: A cross-sectional assessment with optical coherence tomography

      Influence of sleep quality on macula and retinal nerve fiber layer in caucasian healthy adolescents: A cross-sectional assessment with optical coherence tomography

      Abstract Objective: Poor sleep quality have affect on neuronal structure in central nervous system. We aimed to investigate the effects of sleep quality on the thickness of retinal nerve fiber layer (RNFL), macula, and ganglion cell complex (GCC) obtained by optical coherence tomography (OCT) in healthy Caucasian adolescents. Methods: In this prospective cross-sectional study,100 healthy adolescents were evaluated for determining of sleep quality score by the Pittsburgh sleep quality index(PSQI) and were monitored for detection of sleep efficiency(%) by Sense Wear PRO3 Armband mobile monitor(SWA). The sleep quality is evaluated based on the PSQI score and PSQI ...

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    8. Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy

      Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy

      BACKGROUND Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. The variable clinical manifestations may result in differential diagnostic difficulties. The early screening and diagnosis of glaucoma are currently experiencing a demand for anterior segment analysis tools that can gather more information with one short measurement. Therefore, we analyzed the agreement, difference, and correlation of chamber angle parameters such as angel opening distance at 500 μm (AOD500) and trabeculo-iris space area at 500 μm 2 (TISA500) measured by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). AIM To compare the differences ...

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    9. Optical coherence tomography angiography (OCTA) findings of microvascular and neural changes in primary pulmonary hypertension

      Optical coherence tomography angiography (OCTA) findings of microvascular and neural changes in primary pulmonary hypertension

      Aim: To investigate the microvascular and neural changes in primary pulmonary hypertension (PPH) patients compared with healthy controls. Method: Forty-four eyes of 22 PPH patients were included in this observational clinical cohort study, while forty-four eyes of 22 healthy participants were enrolled as controls. Optical coherence tomography angiography (OCTA) images were obtained from each participant using the RTVue XR Avanti device with AngioVue software 2.0. Results: Regarding the total macular-associated vessel density (VD), including that of the superficial and deep retina , the optic disc-associated capillary density (CD), including that of the whole image, CD inside the disc and the ...

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    10. Optical coherence tomography vs fundus photography in detecting macular edema in subjects with type 2 diabetes (Thesis)

      Optical coherence tomography vs fundus photography in detecting macular edema in subjects with type 2 diabetes (Thesis)

      Introduction The screening of diabetic retinopathy has been relied on fundus photography but since it is 2-dimensional, it is difficult to identify diabetic macular edema (DME), which is the most feared ocular complication related to diabetes. Optical coherence tomography (OCT) has been shown to be a useful tool in detecting and monitoring DME. The main objective of this study was to screen people with type 2 diabetes and find out how many patients have current diabetic macular edema and to compare different screening equipment by means of fundus photography and OCT when evaluating macular edema. Method The sample of this ...

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    11. Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

      Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

      Müller cells (MC) represent a key element for the metabolic and functional regulation of the vertebrate retina. The aim of the present study was to test the feasibility of a new method for the in-vivo detection and quantification of extrafoveal MC in human retina. We developed a new approach to isolate and analyse extrafoveal MC in vivo, starting from structural optical coherence tomography data. Our pilot investigation was based on the optical properties of MC, which are known to not interfere with the light reaching the outer retinal structures. We reconstructed MC in the macular region of 18 healthy ...

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    12. Deep Learning Could Transform Ophthalmology

      Deep Learning Could Transform Ophthalmology

      Ophthalmology could be the next specialty to look into utilizing new deep learning technology to screen and diagnose patients with ocular disorders. Nihaal Mehta, MD A team, led by Nihaal Mehta, MD, New England Eye Center, Tufts Medical Center, determined whether a model-to-data deep learning approach without needing to transfer any data can be applied in ophthalmology. In the single-center cross-sectional study, the investigators examined patients with active exudative age-related macular degeneration (AMD) who underwent optical coherence tomography (OCT) at the New England Eye Center between August 2018 and February 2019

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    13. Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Abstract Purpose : To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods : In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT. We autosegmented OCT volumes using custom infant-specific software, extracted RVSV-OCT images from volumetric data bracketed around the retinal pigment epithelium, and automontaged the resulting RVSV-OCT images. Three masked ophthalmologists graded ...

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    14. Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

      Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

      Purpose : To analyze the appearance of structural abnormalities due to hydroxychloroquine (HCQ) toxicity by spectral-domain optical coherence tomography (SD-OCT) and short-wavelength autofluorescence (SW-AF) and near-infrared fundus autofluorescence (NIR-AF) imaging. Methods : This retrospective cohort study included 88 eyes from 44 patients who had a history of or were currently taking HCQ. SD-OCT, SW-AF, and NIR-AF images were analyzed by two independent graders for the detection of HCQ-associated abnormalities. Results : Sixty eyes (30 patients, 68%) presented with no abnormalities for either imaging modality. Twenty eyes (10 patients, 23%) presented with parafoveal abnormalities (ellipsoid zone attenuation and/or interdigitation zone continuity loss) in ...

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  2. Organizations in the News

    1. (3 articles) Baylor College of Medicine
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  5. Picture Gallery

    Comparison of optical coherence tomography-guided versus intravascular ultrasound-guided percutaneous coronary intervention: Rationale and Design of a Randomized, controlled OCTIVUS trial Home OCT with AI analysis may lead to ‘paradigm shift’ in AMD management Bioengineering Professor Stephen Boppart appointed as a Grainger Distinguished Chair of Engineering High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window Comparison of Optical Imaging Techniques to Quantitatively Assess the Perfusion of the Gastric Conduit during Oesophagectomy Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart Machine Learning Techniques for Ophthalmic Data Processing: A Review Non-invasive optical screening of Streptococcus Pneumonia based inflammatory changes of the tympanic membrane and mastoid mucosa in guinea pig otitis media using optical coherence tomography Change in Leadership at OBEL, The University of Western Australia A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy Novel input polarisation independent endoscopic cross polarised optical coherence tomography probe Kubota Vision Demonstrates 3D Imaging Capabilities Using AI on PBOS
  6. Recent Quotes

    1. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    2. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    3. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    4. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    5. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    6. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    7. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    8. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen
    9. We hope that this new lab between SNEC-SERI and NTU will be the start of an important programme to utilise engineering solutions to help and improve care of our patients with eye problems.
      By Tin Aung
    10. “At PhotoniCare we set out to solve the massive problem of frequent misdiagnosis of middle ear infections, and the overuse of antibiotics and referrals to surgery in children that result...We thank the FDA for clearing our TOMi Scope under a new product code unique to our technology, and look forward to bringing this innovation to doctors and patients very soon.”
      By Ryan L. Shelton