1. Recent Articles From Around The Web

    1. Commentary: Posterior polarannular and hemispheric choroidal and retinal dystrophy: Optical coherence tomographic angiography description of a rare case

      Commentary: Posterior polarannular and hemispheric choroidal and retinal dystrophy: Optical coherence tomographic angiography description of a rare case

      During our routine practice, we become busy in a set clinical atmosphere and sometimes ‘see’ what we already have on the back of our minds. The patient may not be responding to a treatment as our diagnosis probably requires a revision. In such scenarios, the case reports of such rare cases are helpful for reference and planning management. In the paper ‘Posterior Polar Annular and Hemispheric Choroidal and Retinal Dystrophy: Optical Coherence tomography angiography description of a rare case’, [1] author/s have described a recently reported retinal disease, posterior polar hemispheric choroidal dystrophy, [2] and commented on its classification ...

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    2. Panoramic optical coherence tomography angiography features in acute zonal occult outer retinopathy

      Panoramic optical coherence tomography angiography features in acute zonal occult outer retinopathy

      AZOOR (acute zonal occult outer retinopathy) is a rare retinal disorder presenting with sudden onset scotoma and photopsia. [1] The pathognomic feature for diagnosing AZOOR is the presence of “trizonal pattern” on fundus autofluorescence (FAF). [2] We present a 36-year-old male complained of scotoma and photopsia since 1 month in both eyes, more predominantly in left eye. On examination, best-corrected visual acuity was 20/20 OU (both eyes). Dilated fundus examination OU showed orange-yellow-colored demarcation line in the peripapillary area [Figure 1] a. FAF imaging OU revealed corresponding abnormal area of speckled hyperautofluorescence around an area of hypoautofluorescence in the ...

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    3. Post-laser regression of diabetic neovascularization: An optical coherence tomography angiography study

      Post-laser regression of diabetic neovascularization: An optical coherence tomography angiography study

      A 57-year-old man with diabetes mellitus was referred to us for management of proliferative diabetic retinopathy. Enface optical coherence tomography angiography (OCTA) montage images were acquired using Zeiss Plex Elite 9000 (CA, USA). Montage view (at level of superficial plexus) showed extensive capillary nonperfusion areas. A well-defined irregular vascular proliferation of fine convoluted exuberant vessels with terminal anastomosis was seen above the superior arcade [Figure 1] a, which corresponded and correlated well to the active neovascularization (NVE) seen on the fundus fluorescein angiography (FFA) (Heidelberg Engineering, Germany) [Figure 1] b. The OCTA section through the vitreo-retinal interface showed proliferation of ...

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    4. Commentary: Influence of orientation of the external linear incision created by the 25-gauge trocar and related factors on sclerotomy closure: A clinical and optical coherence tomographic study

      Commentary: Influence of orientation of the external linear incision created by the 25-gauge trocar and related factors on sclerotomy closure: A clinical and optical coherence tomographic study

      The panorama of vitreoretinal surgery has considerably transformed with the advent of microincision vitrectomy surgery (MIVS). [1] Although the central idea of MIVS was to create a microincision sclerotomy, it never accomplished the goal of being sutureless. In our clinical experience, we advocate the concept of suturing the port site, if needed, to avoid postoperative wound leak and hypotony. [2] The art of wound construction is the talk of the town in the current scenario of vitreoretinal surgery to avoid untoward complication and even in terms of cosmesis. The IJO article “Influence of orientation of the external linear incision created ...

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    5. Influence of orientation of the external linear incision created by the 25-gauge trocar and related factors on sclerotomy closure: A clinical and optical coherence tomographic study

      Influence of orientation of the external linear incision created by the 25-gauge trocar and related factors on sclerotomy closure: A clinical and optical coherence tomographic study

      Purpose: To assess the influence of orientation of the external linear incision created by the trocar and related factors on sclerotomy closure in 25-gauge (25G) transconjunctival vitreous surgery (TVS). Methods: A total of 46 eyes of 46 patients who underwent 25G TVS (23 circumferential incisions and 23 radial incisions) were studied. Clinical and anterior segment optical coherence tomography (AS-OCT)-based comparison of self-sealed and sutured sclerotomies was done. The influence of age, ocular surgeries and injections, axial length, cannula type, sclerotomy quadrant, surgery duration, vitreous base excision, and tamponade on suture rates was analyzed. Results: Of the 46 eyes, 23 ...

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    6. ”Double-layer sign” on spectral domain optical coherence tomography in pachychoroid spectrum disease

      ”Double-layer sign” on spectral domain optical coherence tomography in pachychoroid spectrum disease

      Purpose: The “double-layer sign (DLS)” describes the shallow and irregular elevation of the retinal pigment epithelium from the underlying intact Bruch's membrane visualized on the spectral domain optical coherence tomography. In this study, we evaluated the frequency, characteristics of the space within the double layer and other features in the pachychoroid spectrum to aid the clinical diagnosis of these variants. Methods: This retrospective study evaluated the features of the DLS on multimodal imaging in consecutive patients with a clinical diagnosis of one of the four variants of pachychoroid: pachychoroid pigment epitheliopathy (PPE), pachychoroid neovasculopathy (PCN), chronic central serous chorioretinopathy ...

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    7. Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration

      Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration

      Purpose: To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospective, interventional study. Methods: Patients with wet AMD were treated with 3 injections of intravitreal anti-VEGF at monthly intervals for 3 months and followed at 1, 2, 3, and 6 months postinjection. Using “overlay” features, morphologic characteristics of OCTA at the site of choroidal neovascular membrane (CNVM) lesion were analyzed and correlated functionally with MP3. Data were collected including visual acuity at ...

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    8. Current role of optical coherence tomography angiography: Expert panel discussion

      Current role of optical coherence tomography angiography: Expert panel discussion

      Optical coherence tomography (OCT) angiography is a promising technique that provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging and offers several advantages over conventional angiography to visualize the chorioretinal vasculature in a rapid and noninvasive manner. However, as with any evolving imaging technique, there are ongoing challenges in terms of need for new equipment, limitations of imaging capability and software processing techniques, as well as in understanding the implications of the imaging and its correlation with pathophysiology of the retina and choroid. This ...

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    9. Revolution in evolution

      Revolution in evolution

      The learning and practice of vitreoretinal disorders have undergone a radical transformation in the past decade. The pace of innovation in this subspecialty is astounding. Treatments, techniques, and technologies that are the standard of care today did not even exist a decade ago. Advances in diagnostic technologies such as optical coherence tomography (OCT). OCT angiography and multimodal imaging and their widespread application in routine clinical practice have catalyzed paradigm changes in the medical treatment of several common retinal conditions. New-found delight in treating previously untreated or undertreated disorders and the quest to further excel have created a constant need for ...

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    10. Relationship between optic nerve head and retinal nerve fiber layer with central corneal thickness in primary open angle glaucoma: A three-dimensional optical coherence tomography study

      Relationship between optic nerve head and retinal nerve fiber layer with central corneal thickness in primary open angle glaucoma: A three-dimensional optical coherence tomography study

      INTRODUCTION: The purpose of the study is to evaluate the relationship between optic nerve head (ONH) parameters, and retinal nerve fiber layer (RNFL) thickness with central corneal thickness (CCT) in primary open angle glaucoma (POAG) patients by using three dimensional spectral domain optical coherence tomography (3D SD-OCT). METHODS: In this cross-sectional study, a total of 144 eyes of 144 patients (79 female, 65 male) with POAG were studied. Patients were classified as thick cornea group (Group 1) and thin cornea group (Group 2). Group 1 represented eyes with CCT≥540μm and Group 2 with CCT< 540μm. Topographic measurements ...

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    11. Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

      Automated macular segmentation with spectral domain optical coherence tomography in the fellow eyes of patients with unilateral retinal vein occlusion

      Purpose To assess the change in the macular layers in the fellow eyes of unilateral retinal vein occlusion (RVO) patients and to evaluate whether certain layers are more affected based on RVO type. Methods This retrospective study included 87 fellow eyes of patients with unilateral RVO (26 central, 61 branch) and 105 eyes of 105 subjects without RVO. Spectral domain optical coherence tomography was used for automatized retinal segmentation. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cells, inner plexiform, inner nuclear, outer plexiform, outer nuclear, photoreceptor layers, overall inner retinal layers and retinal pigment epithelium (RPE) were documented ...

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    12. Corneal Curvature Measurements Utilizing a New Swept-source Optical Coherence Tomography Tomey OA-2000® and Comparison With IOL Master® 500 in Pterygium Patients

      Corneal Curvature Measurements Utilizing a New Swept-source Optical Coherence Tomography Tomey OA-2000® and Comparison With IOL Master® 500 in Pterygium Patients

      Introduction: Corneal curvature (CC) is an important anterior segment parameter. This study compared CC measurements conducted with two optical devices in pterygium eyes. Methods: Sixty pterygium eyes of 30 patients were enrolled in this study. CC was measured three times with the optical biometer and topography-keratometer Tomey OA-2000 (Tomey Corporation, Nagoya, Japan), then with partial optical coherence interferometry (PCI) IOL Master 500 (Carl Zeiss Meditec, Dublin, CA) and data were statistically analysed. Results: The measurements revealed in a mean CC of 43.86 ± 1.57 D with Tomey OA-2000 and 43.84 ± 1.55 D with IOL Master. Distribution of ...

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    13. Optical coherence tomography angiography features of paracentral acute middle maculopathy in a young female in sub-Saharan Africa: A case report

      Optical coherence tomography angiography features of paracentral acute middle maculopathy in a young female in sub-Saharan Africa: A case report

      To report the Optical Coherence Tomography Angiography features of a 33-year-old female presenting with visual loss secondary to a paracentral acute middle maculopathy. A case report of clinical examination findings, Fundus fluorescein angiography and Angiovue optical coherence tomography angiography (OCTA) findings of a paracentral acute middle maculopathy. The Angiovue optical coherence tomography angiography (OCTA) software of the RTVue XR Avanti (Optovue, Inc., Fremont, CA) was used for imaging. Enface OCTA images demonstrate a hypereflective plaque extending from the supero temporal area of the optic disc to the perifovealarea. The 3.0 x 3.0 mm enface OCTA retina thickness map ...

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    Retinal optical coherence tomography image enhancement via deep learning Avinger Provides Third Quarter 2018 Shareholder Update Recovering distance information in spectral domain interferometry Understanding congenital heart defects to prevent them Cardiac OCT: 20 Years from Bench to Erosion Postdoctoral and Research Scientist Positions in Biomedical Imaging at Baylor College of Medicine Product Development Engineer Opening at Opticent Health Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery A marine biofilm flow cell for in situ screening marine fouling control coatings using optical coherence tomography NinePoint Medical Announces FDA Clearance of an Artificial Intelligence Software Upgrade for the NvisionVLE Imaging System Flying through the coronary easily Conavi Medical and Japan Lifeline Advance Japanese Sales Strategy of Novasight Hybrid Intravascular Imaging System
  6. Recent Quotes

    1. When the heart develops, it becomes stiffer as required for ability to contract and pump blood...So the question is - does it become stiff because it's contracting, or is it stiff to begin with because it is genetically predefined?
      By Kirill V. Larin
    2. One out of every 100 babies in the United States has a congenital heart defect leading to death...Understanding biomechanical regulation of heart development is highly important for better management of congenital heart defects.
      By Irina V. Larina
    3. The clearance of the IRIS product marks the successful culmination of a multi-year development effort within our organization, and with the Food and Drug Administration...This product is something we at NinePoint, and our customers, are very excited to bring to market. We pride ourselves in customer responsiveness and innovation, key inputs to this new product. We are eager to roll this out in a controlled-market release in the coming months prior to making the technology more broadly available.
      By Eman Namati
    4. The announcement of Japan Lifeline applying for regulatory approval is an important commercial event for the company. Intravascular imaging is used frequently in the 260,000 angioplasty and stenting procedures performed every year in Japan. The Novasight Hybrid system is uniquely able to simultaneously acquire inherently co-registered IVUS and OCT images. I have been fortunate to work with a number of cardiologists in Japan whose experience and knowledge of intravascular imaging is incredibly profound. The input that we have received from Japanese physicians in the development of our product has been incredibly valuable in ensuring that our technology fits well with their clinical needs.
      By Brian K. Courtney
    5. We appreciate Novartis Pharma AG’s commitment to advancing development of a practical device that will enable patients to monitor progression of vision-threatening retinal diseases at home...Home monitoring and rapid reporting of results to treating physicians has the potential to dramatically transform this burdensome patient care model. Most importantly, it will help patients around the world get the full benefit of today’s sight-saving therapies.
      By Don Bogue
    6. The patient-focused goals of this Compact Imaging/Novartis collaboration complement Novartis’ efforts to introduce new anti-VEGF therapeutics for active AMD and DME that will reduce the frequency of injections, extend the time between follow-up visits and provide physicians new tools to help manage these serious chronic conditions...Clinically useful data on retinal disease progression from home monitoring devices also could prove extremely valuable in optimizing drug dosing and future drug development.
      By Michael R. Hee
    7. The addition of OCT angiography to Heidelberg’s SPECTRALIS multimodal platform allows for the evaluation of retinal and choroidal vascular abnormalities in a noninvasive manner...I believe OCTA will soon become invaluable in our daily clinical routine for screening and diagnosing chorioretinal disorders.”
      By Nadia K. Waheed
    8. We will create this hybrid microscope putting these two powerful technologies together. OCT will image the development of the neural tube while at the same time, Brillouin spectroscopy will probe its mechanical properties. We will be imaging and sensing at the same time...If we find out what causes the tube to close, what is exactly happening, we can develop new drug treatments for at-risk embryos...It's still one of the great mysteries of life, no one on earth knows how this happens and that is really exciting to us, because we will be the ones to find out.
      By Kirill V. Larin
    9. The purported advantages of the synergistic information that IVUS and OCT can provide have been highly anticipated in the interventional cardiology community...These cases performed in Hamilton represent the first worldwide clinical use of any system that combines IVUS with OCT on a single catheter. In an era of personalized and precision medicine, we believe that the ability to collect comprehensive imaging data in patients with coronary artery disease (CAD) provides an important opportunity to generate improved clinical decision-making capabilities for these patients in the future.
      By Brian K. Courtney
    10. The Ganymede series has proven to be an excellent tool for a multitude of imaging applications,...The Thorlabs OCT application team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner