1. Featured Articles

    1. Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market

      First U.S. clinical trial initiated with patient-operated home OCT device for monitoring patients diagnosed with exudative age-related macular degeneration (eAMD) Notal Vision, Inc., (“Notal”) a privately-held ophthalmic diagnostic services company, focused on advancing eye care by extending ophthalmic disease management from the clinic to the home, has announced the achievement of a significant milestone in its plan to develop and commercialize a home-based, patient-operated, spectral-domain optical coherence tomography (SD-OCT) system. The first targeted application of the Notal Home OCT is to monitor exudative (wet) age-related macular degeneration (eAMD) patients between scheduled, standard-of-care examinations by their treating retinal specialist. Notal ...

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      Mentions: Wasatch Photonics FDA Nishant Mohan

    2. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Explore archivesofpathology.org Urology
      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    3. In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

      Explore archivesofpathology.org Microscopy
      In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

      The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or also in freshly excised tissue, termed ex vivo microscopy. Both in vivo and ex vivo microscopy have tremendous potential for clinical impact in a wide variety of applications. However, in ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    4. Moody's says Excelitas' proposed $80 million first lien term loan facility to acquire Axsun is a moderate credit negative; ratings unaffected

      Explore Optical Coherence Tomography News Acquisition , Other Business News
      Moody's says Excelitas' proposed $80 million first lien term loan facility to acquire Axsun is a moderate credit negative; ratings unaffected

      Moody's Investors Service ("Moody's") says EXC Holdings III Corp.'s (dba Excelitas) proposed $80 million incremental first lien term loan facility to fund the acquisition of Axsun is a modest credit negative, but it does not impact the company's B3 Corporate Family Ratings or stable rating outlook. Following the add-on, the USD denominated first lien term loan will increase to $685 million from $605 million ($681 million outstanding proforma at September 30, 2018). The $80 million proceeds along with $1.2 million of cash on hand will be used to fund the acquisition and approximately $5 million ...

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      Mentions: Axsun Technologies

    5. Mid-infrared Fourier-domain optical coherence tomography with a pyroelectric linear array

      Explore OSA | OSA Publishing NDE/NDT
      Mid-infrared Fourier-domain optical coherence tomography with a pyroelectric linear array

      Optical technology in the mid-infrared wavelength range is currently a rapidly developing field initiated by the availability of novel high-power and spatially coherent sources. Non-destructive testing techniques based on these sources are very promising for industrial and medical applications. However, there are still many engineering problems due to the technical challenges and high prices of the optical elements suitable for the mid-infrared region. In this paper, we report the development and performances of the first mid-infrared Fourier-domain optical coherence tomography based on a supercontinuum source and low-cost pyroelectric detector. The system is designed to operate in the spectral region around ...

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      Mentions: Bettina Heise RECENDT

    6. Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples

      Explore arxiv.org
      Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples

      Optical coherence tomography (OCT) is being increasingly adopted as a label-free and non-invasive technique for biomedical applications such as cancer and ocular disease diagnosis. Diagnostic information for these tissues is manifest in textural and geometric features of the OCT images which are used by human expertise to interpret and triage. However, it suffers delays due to long process of conventional diagnostic procedure and shortage of human expertise. Here, a custom deep learning architecture, LightOCT, is proposed for classification of OCT images into diagnostically relevant classes. LightOCT is a convolutional neural network with only 2 convolutional layers and a fully connected ...

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      Mentions: Dalip Singh Mehta Indian Institute of Technology at Delhi Nanyang Technological University

    7. Direct comparison of optical coherence tomography and high-definition 60-MHz intravascular ultrasound imaging of intra-procedural stent thrombosis in a patient with acute coronary syndrome

      Explore ScienceDirect Cardiology
      Direct comparison of optical coherence tomography and high-definition 60-MHz intravascular ultrasound imaging of intra-procedural stent thrombosis in a patient with acute coronary syndrome

      An 80-year-old man with ST-segment elevation myocardial infraction underwent coronary stenting using an everolimus-eluting stent, which resulted in a good coronary flow with no residual stenosis. However, 10 min after final coronary angiography, the patient complained of chest discomfort and the ECG again showed ST elevation. Repeat coronary angiography revealed multiple contrast filling defects in the stent. High-definition 60-MHz intravascular ultrasound (IVUS) examination showed multiple low echoic structures inside the stent, though its visualization was not clear. We also conducted optical coherence tomography (OCT) for further investigation, which clearly delineated the outline of the thrombus. An additional balloon dilatation was ...

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      Mentions: Kyoto University Graduate School of Medicine

    8. Opening for Technology Director – Core Products at Volk Optical Inc.

      Explore Optical Coherence Tomography News Jobs & Studentships
      Opening for Technology Director – Core Products at Volk Optical Inc.

      Position Summary The Technology Director role presents an exciting opportunity to lead and mentor a highly talented, dynamic and motivated team of engineers working on sustaining, enhancing and developing of currently marketed and new core products including diagnostic, laser and surgical lenses, surgical systems and marketed diagnostic imaging devices. The Product Development team at Volk embraces a culture of collaborative teamwork, impactful & customer-centric innovation, free exchange of ideas, fast-paced development, entrepreneurial mindset and can-do attitude. The ideal candidate will be a hands-on leader with a strong technical background and track record of developing new medical device products. The Director will ...

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      Mentions: Utkarsh Sharma

    9. Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane

      Explore SPIE Digital Library Otolaryngology , Probes
      Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane

      An endoscopic optical coherence tomography (OCT) system with a wide field-of-view of 8 mm is presented, which combines the image capability of endoscopic imaging at the middle ear with the advantages of functional OCT imaging, allowing a morphological and functional assessment of the human tympanic membrane. The endoscopic tube has a diameter of 3.5 mm and contains gradient-index optics for simultaneous forward-viewing OCT and video endoscopy. The endoscope allows the three-dimensional visualization of nearly the entire tympanic membrane. In addition, the oscillation of the tympanic membrane is measured spatially resolved and in the frequency range between 500 Hz and ...

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      Mentions: Julia Walther Dresden University of Technology Edmund Koch

    10. Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Explore Optical Coherence Tomography News Ophthalmology , Funding , Other Business News
      Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System

      Notal Vision, Ltd., ("Notal") a privately-held ophthalmic diagnostic services company, focused on advancing eye care by extending ophthalmic disease management from the clinic to the home, has announced the U.S. Food and Drug Administration (FDA) granted the Notal Vision Home-based Optical Coherence Tomography (OCT) System with "Breakthrough Device" designation for the agreed upon indications for use. This designation indicates that FDA intends to provide interactive and timely communication with the sponsor during device development and throughout the review process for various types of premarket submissions. FDA's Breakthrough Devices Program was established in late 2016 to help patients gain ...

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      Mentions: FDA Notal Vision Susan Orr

    12. Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance

      Explore Optical Coherence Tomography News Dermatology , Other Business News
      Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance

      A new clinical study has shown that Dynamic Optical Coherence Tomography imaging of melanomas (D-OCT) reveals changes to the blood vessels that correlate with the depth of invasion of the melanoma. Researchers believe this could lead to a new faster method of rapidly assessing how dangerous a given melanoma is. A more rapid assessment of the risk would potentially allow patients with more serious invasive disease access to the right treatment more directly, doing away with delays inherent in the traditional diagnosis. The technique may also lead to reducing the number of patients with less aggressive tumours receiving sentinel lymph ...

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      Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen

    13. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      Explore MDPI Open Access Journals Platform Gastroenterology
      Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      (1) Background: Barrett’s esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barrett’s esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply it to investigate the characteristics of SHSs in BE using clinical VLE data; (2) Methods: SHSs were identified with an initial detection followed by machine learning. Comprehensive SHS ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University

    14. Optical coherence tomography for intracranial aneurysms: a new method for assessing the aneurysm structure

      Explore ScienceDirect Cardiology , Neurology
      Optical coherence tomography for intracranial aneurysms: a new method for assessing the aneurysm structure

      Background There is a lack of precise methods for predicting the risk of aneurysm rupture. Therefore, prophylactic treatment is used, which leads to unnecessary potential complications. A new modality enabling a more accurate risk assessment is needed. Optical coherence tomography (OCT) is a new-generation imaging technology that has astonishing resolution for vascular imaging. In this study, OCT was used for the evaluation of intracranial aneurysms. Methods In vivo OCT imaging was performed for aneurysms induced in 6 rabbits and in 9 intracranial aneurysm patients. Catheters were cut short to prevent any extra length from damaging aneurysms and tissues. Images of ...

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      Mentions: Fudan University

    15. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Explore Home - Springer Urology
      Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT in humans up to December 2017. Reviews were excluded. Case reports were excluded, unless they presented a landmark in the development of OCT. Results Out of 878 articles, 17 relevant ...

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      Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin

    16. Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine

      A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow or instructor at Harvard Medical School, commensurate with the applicant’s experience. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research. The fellowship will focus on high resolution OCT imaging ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    17. Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      Explore OSA | OSA Publishing Oncology
      Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      It has been demonstrated that optical coherence micro-elastography (OCME) provides additional contrast of tumor compared to optical coherence tomography (OCT) alone. Previous studies, however, have predominantly been performed on mastectomy specimens. Such specimens typically differ substantially in composition and geometry from the more clinically relevant wide-local excision (WLE) specimens excised during breast-conserving surgery. As a result, it remains unclear if the mechanical contrast observed is maintained in WLE specimens. In this manuscript, we begin to address this issue by performing a feasibility study of OCME on 17 freshly excised, intact WLE specimens. In addition, we present two developments required to ...

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      Mentions: Brendan F. Kennedy

    18. Understanding congenital heart defects to prevent them

      Explore EurekAlert! Cardiology , Developmental Biology
      Understanding congenital heart defects to prevent them

      To understand cardiovascular failures, the leading cause of birth defect-related deaths in infants, UH professor of biomedical engineering Kirill Larin is teaming up with Baylor College of Medicine professor of cellular and molecular physiology Irina Larina on a chicken and egg hunt. "When the heart develops, it becomes stiffer as required for ability to contract and pump blood," said Larin. "So the question is - does it become stiff because it's contracting, or is it stiff to begin with because it is genetically predefined?" Surprisingly, very little is known about an embryo's developing heart. "Defining how these mechanical factors ...

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      Mentions: National Institutes of Health Baylor College of Medicine Kirill V. Larin

    19. Cardiac OCT: 20 Years from Bench to Erosion

      Explore IIS Windows Server Cardiology
      Cardiac OCT: 20 Years from Bench to Erosion

      A 1 hr lecture on intravascular optical coherence tomography by IV-OCT pioneer Dr. IK-Kyung Jang, MD, PhD. Dr. Jang came to Massachusetts General Hospital in 1987 from Leuven University in Belgium, where he has completed his residency in medicine and fellowship in cardiology. He also successfully defended his doctorate thesis at the same university. After his advanced fellowship in cardiology at MGH, he joined the staff and is currently working as a Physician and an interventional cardiologist in the Cardiology Division. He holds currently an academic title of Professor of Medicine at Harvard Medical School. A recipient of the Partners ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    20. Artificial intelligence and deep learning in ophthalmology

      Explore BJO Online Ophthalmology
      Artificial intelligence and deep learning in ophthalmology

      Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc, macular oedema and age-related macular degeneration. DL in ocular imaging may be used in conjunction with telemedicine as a possible solution to screen, diagnose and monitor major eye diseases for ...

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      Mentions: University College London Medical University of Vienna Oregon Health & Science University
    21. See all articles

  2. Recent Articles From Around The Web

    1. Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook)

      Explore theiet.org
      Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook)

      Semiconductor lasers are small, reliable, low cost, high-performance and user-friendly optical devices which make them highly suitable for a variety of biomedical applications. This edited book gathers experts in the field to cover the fundamentals and technology advances of semiconductor lasers and diode-based lasers with a focus on their applications in medical optics and biophotonics including edge-emitting semiconductor lasers and light emitting diodes, Q-switched and mode-locked lasers, quantum cascade lasers, semiconductor disk lasers, near-infrared spectroscopy systems for biomedical applications, bio-medical Raman spectroscopy, nonlinear imaging and optical coherence tomography.

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      Mentions: Peter E. Andersen Technical University of Denmark (DTU) Sebastian Marschall

    4. Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis

      Explore Journals | PLOS Ophthalmology
      Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis

      Background This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). Methods This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behçet uveitis. The main outcome measure was comparison of mean CMT and MV with the types of Behçet uveitis. Results Sixty ...

      Read Full Article

    5. Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography

      Explore KoreaMed Synapse Ophthalmology
      Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography

      Purpose We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye. Methods We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 µm, while group B had a size of ≥400 µm. Repeatability was determined by comparing the thicknesses of the GCIPL ...

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      Mentions: Chungnam National University Hospital

    6. Line-field confocal time-domain optical coherence tomography with dynamic focusing

      Explore OSA | OSA Publishing
      Line-field confocal time-domain optical coherence tomography with dynamic focusing

      A time-domain optical coherence tomography technique is introduced for high-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. Quasi-isotropic spatial resolution of 1.3 µm × 1.1 µm (lateral × axial) is achieved. In vivo cellular-level resolution imaging of human skin is demonstrated at 10 frames per second with a penetration depth of ∼500 µm.

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      Mentions: Arnaud Dubois

    7. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Explore BJO Online Ophthalmology
      Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Purpose To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort. Results 164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more ...

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      Mentions: University of Bern Bern University Hospital

    8. Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

      Purpose To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA). Methods Sixty-two children with OSAS (124 eyes; 5.94 ± 1.64 years old; 53.2% boys) were enrolled in this study. Their retinal vascular network density indices, including vascular diameter (VD), vascular area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI) on the macular superficial/deep capillary plexus (SCP/DCP), and the size of the foveal avascular zone (FAZ) were analyzed by OCTA before treatment and ...

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    9. Optical coherence tomography imaging of melanoma skin cancer

      Explore Home - Springer Dermatology
      Optical coherence tomography imaging of melanoma skin cancer

      No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Two ...

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    10. COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER

      Explore LWW Online Ophthalmology
      COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER

      Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP. Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Results: The intraocular pressure at 1 hour and 6 hours after PRP was significantly raised in both groups. Mean intraocular pressure was 21.17 ± 4 ...

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    11. Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Explore IOVS Journal Ophthalmology
      Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Purpose : To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA). Methods : Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Based on clear decorrelation signals, four vascular slabs were segmented, comprising one each in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and top and bottom of the inner nuclear layer (INL). Qualitative features and quantitative measurements in each slab ...

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      Mentions: Akitaka Tsujikawa Kyoto University Graduate School of Medicine Sotaro Ooto

    12. Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Explore BMC Ophthalmology Ophthalmology
      Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Background Despite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements. Methods Cross sectional observational cohort study. Subjects with normal eyes were recruited. Two sets of optical coherence tomography angiography images of macula and optic nerve head were acquired during one visit. Novel in-house developed software was used to count the pixels in each images and to ...

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    13. Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      Explore OSA | OSA Publishing
      Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      In this Letter, we propose a beam-shifting optical coherence tomography scheme for speckle reduction and blood flow rate calculation, where variations of the speckle pattern and Doppler angle were generated by parallel shifting of the sample beam incident on the objective lens. The resultant optical coherent tomography images could then be averaged for speckle noise reduction and simultaneously analyzed for flow rate measurement. The performance of the proposed technique was verified by both phantom and in vivo experiments.

      Read Full Article
      Mentions: University of Toronto Sunnybrook Health Sciences Centre Victor X. D. Yang

    14. Axsun Technologies Announces Definitive Agreement to be acquired by Excelitas Technologies

      Explore Optical Coherence Tomography News Acquisition , Other Business News
      Axsun Technologies Announces Definitive Agreement to be acquired by Excelitas Technologies

      Axsun Technologies Inc., an Anzu Partners portfolio company, today announced that it has signed a definitive agreement to be acquired by Excelitas Technologies ® Corp., a global technology leader focused on delivering innovative, customized photonic solutions. The terms of the agreement are not being disclosed and the transaction is expected to close in early 2019. Jonathan Hartmann , CEO of Axsun, commented, "This is an outstanding opportunity for Axsun, our customers, and our employees as we continue to expand our product line and develop new markets together with Excelitas." "Our partnership with Anzu Partners has been outstanding, and we are grateful for ...

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      Mentions: Axsun Technologies

    15. Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Explore American Journal of Ophthalmology Ophthalmology
      Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) criteria and clinical data with pathology of the vitreomacular interface (VMI) in eyes with diabetic macular edema (DME). Design Retrospective cross-sectional study and laboratory investigation. Methods We included specimens of 27 eyes of 26 patients with center-involved DME that underwent vitrectomy with peeling of the internal limiting membrane (ILM). Selection of specimens was consecutive and in retrospect using our register of the Vitreoretinal Pathology Unit. Clinical data and SD-OCT examinations were correlated to immunocytochemistry and transmission electron microscopy. Classification of DME comprised sponge-like diffuse retinal thickening, cystoid macular edema, and serous retinal ...

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      Mentions: Ludwig Maximilian University of Munich
      16. See all articles
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    1. (2 articles) Harvard University
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    1. (2 articles) Guillermo J. Tearney
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  8. OCT Companies in the News

    1. (2 articles) Axsun Technologies
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  9. Picture Gallery

    Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice Moody's says Excelitas' proposed $80 million first lien term loan facility to acquire Axsun is a moderate credit negative; ratings unaffected Mid-infrared Fourier-domain optical coherence tomography with a pyroelectric linear array Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples Direct comparison of optical coherence tomography and high-definition 60-MHz intravascular ultrasound imaging of intra-procedural stent thrombosis in a patient with acute coronary syndrome Opening for Technology Director – Core Products at Volk Optical Inc. Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System Intravascular Optical Coherence Tomography for Neurointerventional Surgery Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance

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    1. The initiation of our first U.S. based home OCT clinical trial is an important step towards bringing this leading-edge technology to eAMD patients, their caregivers, and the eye care community...Our collaboration with Wasatch Photonics will continue to be instrumental to our organization as the U.S. Food and Drug Administration (FDA) recently granted our Home Optical Coherence Tomography (OCT) System with ‘Breakthrough Device Designation’, a program designed to expedite patient access to novel technologies.
      By Susan Orr
    2. Our tests verified that a greatly reduced amount of experimental data can be used to reconstruct reasonable 3-D OCT images...After we perform enough experiments to demonstrate that our probe and imaging method are useful for observing malignant features, our technique will be ready for clinical trials...This work is just one example of applying computational techniques to imaging applications...We expect that similar approaches may be helpful for improving the experiment designs and data acquisition for many imaging modalities.
      By Jigang Wu
    3. Our goal with this work is to help develop a faster, more efficient and less invasive diagnostic and treatment pathway for melanoma. Patients with advanced disease should get aggressive treatment as quickly as possible; also those with early-stage melanomas should not have to undergo expensive invasive Sentinel Lymph Node Biopsy operations if their melanoma is reliably confirmed as very low-risk. We believe Dynamic OCT imaging could help with these goals and the results of this study are very encouraging. The next stage of our work is to analyse the link between vessel shapes and the actual degree of metastasis of the melanomas in a larger cohort, and not just the Breslow depth.
      By Julia Welzel
    4. When the heart develops, it becomes stiffer as required for ability to contract and pump blood...So the question is - does it become stiff because it's contracting, or is it stiff to begin with because it is genetically predefined?
      By Kirill V. Larin
    5. One out of every 100 babies in the United States has a congenital heart defect leading to death...Understanding biomechanical regulation of heart development is highly important for better management of congenital heart defects.
      By Irina V. Larina
    6. The clearance of the IRIS product marks the successful culmination of a multi-year development effort within our organization, and with the Food and Drug Administration...This product is something we at NinePoint, and our customers, are very excited to bring to market. We pride ourselves in customer responsiveness and innovation, key inputs to this new product. We are eager to roll this out in a controlled-market release in the coming months prior to making the technology more broadly available.
      By Eman Namati
    7. The announcement of Japan Lifeline applying for regulatory approval is an important commercial event for the company. Intravascular imaging is used frequently in the 260,000 angioplasty and stenting procedures performed every year in Japan. The Novasight Hybrid system is uniquely able to simultaneously acquire inherently co-registered IVUS and OCT images. I have been fortunate to work with a number of cardiologists in Japan whose experience and knowledge of intravascular imaging is incredibly profound. The input that we have received from Japanese physicians in the development of our product has been incredibly valuable in ensuring that our technology fits well with their clinical needs.
      By Brian K. Courtney
    8. We appreciate Novartis Pharma AG’s commitment to advancing development of a practical device that will enable patients to monitor progression of vision-threatening retinal diseases at home...Home monitoring and rapid reporting of results to treating physicians has the potential to dramatically transform this burdensome patient care model. Most importantly, it will help patients around the world get the full benefit of today’s sight-saving therapies.
      By Don Bogue
    9. The patient-focused goals of this Compact Imaging/Novartis collaboration complement Novartis’ efforts to introduce new anti-VEGF therapeutics for active AMD and DME that will reduce the frequency of injections, extend the time between follow-up visits and provide physicians new tools to help manage these serious chronic conditions...Clinically useful data on retinal disease progression from home monitoring devices also could prove extremely valuable in optimizing drug dosing and future drug development.
      By Michael R. Hee
    10. The addition of OCT angiography to Heidelberg’s SPECTRALIS multimodal platform allows for the evaluation of retinal and choroidal vascular abnormalities in a noninvasive manner...I believe OCTA will soon become invaluable in our daily clinical routine for screening and diagnosing chorioretinal disorders.”
      By Nadia K. Waheed