1. Feature Of The Week

    There has been increasing interest on the development of clinically acceptable, more sensitive and specific methods for non-invasive diagnosis in Periodontics. In this pilot study, the performance of an Optical Coherence Tomography (OCT) system in imaging periodontal structures in humans was evaluated. Gingival sulcus depth measurements were obtained and compared with traditional probes. In total, 445 sites of 23 periodontally healthy individuals were measured by 3 instruments: North Carolina manual probe, Florida automated probe and OCT at 1325 nm. To obtain quantitative measurements from OCT images, the gingival refractive index was also determined. Discomfort/pain perception and the duration of examinations were compared among the instruments. The analysis of OCT images allowed the identification of relevant anatomic dental and periodontal regions. The average sulcus depth measured by OCT, 0.85 ± 0.27 mm and 0.87 ± 0.28 mm, was lower than the values obtained by manual and automated probing. Discomfort/pain were prevalent for traditional probes, which are invasive methods, than for the non-invasive OCT technique. OCT has the potential to be a reliable tool for in vivo periodontal tissues evaluation and for reproducible sulcus depth measurements in healthy sites. Further technological advances are required to reduce the procedure time and promote evaluation of posterior oral regions.

    For more information see recent Article. Courtesy Anderson Gomes from Federal University of Pernambuco. To share this article click Here.

  2. Featured Articles

    1. Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity

      Explore arxiv.org Tunable Sources
      Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity

      High frequency fluctuation in the optical signal generated in Fourier-Domain Mode Locked fiber laser (FDML-FL), which is the major problem and degrades the laser performance, is not yet fully analyzed or studied. The basic theory which is causing this high frequency fluctuation is required to clearly understand its dynamics and to control it for various applications. In this letter, by analyzing the signal and system dynamics of FDML-FL, we theoretically demonstrate that the high frequency fluctuation is induced by the intrinsic instability of frequency offset of the signal in cavity with nonlinear gain and spectral filter. Unlike the instabilities observed ...

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      Mentions: University of Washington University of Aberdeen Hong Kong Polytechnic University

    2. Extended depth of focus for coherence-based cellular imaging

      Explore OSA | OSA Publishing
      Extended depth of focus for coherence-based cellular imaging

      Improving lateral resolution for cross-sectional optical coherence tomography (OCT) imaging is difficult due to the rapid divergence of light once it is focused to a small spot. To overcome this obstacle, we introduce a fiber optics system that generates a coaxially focused multimode (CAFM) beam for depth of focus (DOF) extension. We fabricated a CAFM beam OCT probe and show that the DOF is more than fivefold that of a conventional Gaussian beam, enabling cross-sectional imaging of biological tissues with clearly resolved cellular and subcellular structures over more than a 400 μm depth range. The compact and straightforward design and ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    3. Postdoctoral Fellow, Bioengineering at University of Maryland - College Park

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Fellow, Bioengineering at University of Maryland - College Park

      We are seeking a postdoctoral fellow to pursue research on developing novel optical imaging devices and applications on cancer diagnosis, functional brain imaging and tissue engineering. Candidates must hold a Ph.D. in engineering, physics, or related fields and have prior experience with Optics, OCT, Microscopy (e.g. fluorescence, confocal, Two-photon), and image analysis software development. Experience with cell culture and/or animals experiments is a plus. Please submit a cover letter with a brief description of research experience, interests, and career goals (≤ 2 pages), CV with complete list of publications, and contact information for 3 references in a single ...

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      Mentions: University of Maryland Yu Chen

    4. Research Associate/ Research Fellow at University of Western Australia

      Explore Optical Coherence Tomography News Jobs & Studentships
      Research Associate/ Research Fellow at University of Western Australia

      Job no: 499166 Work type: full-time Location: Crawley Categories: Engineering and Mathematical Sciences UWA Faculty of Engineering and Mathematical Sciences School of Electrical, Electronic and Computer Engineering 1 year fixed term appointment Level A/B position: $67,352 - $114,250 per annum The University of Western Australia (UWA) is ranked amongst the top Australian universities and a member of the prestigious Group of Eight research-intensive universities ranked among the top 100 universities in the world. About the work area You will be a member of BRITElab in the School of Electrical, Electronic and Computer Engineering within the Faculty of Engineering ...

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      Mentions: University of Western Australia Sir Charles Gairdner Hospital Brendan F. Kennedy

    5. Postdoctoral Research Scientist Position at Colgate-Palmolive Company in Piscataway New Jersey

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Scientist Position at Colgate-Palmolive Company in Piscataway New Jersey

      Colgate-Palmolive is a leading global consumer products company, tightly focused on Oral Care, Personal Care, Home Care and Pet Nutrition. Colgate sells its products in over 200 countries and territories around the world under such internationally recognized brand names as Colgate, Palmolive, Speed Stick, Lady Speed Stick, Softsoap, Irish Spring, Protex, Sorriso, Kolynos, elmex, Tom’s of Maine, Sanex, Ajax, Axion, Fabuloso, Soupline and Suavitel, as well as Hill’s Science Diet, Hill’s Prescription Diet and Hill’s Ideal Balance. For more information about Colgate’s global business, visit the Company’s web site at http://www.colgatepalmolive.com ...

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      Mentions: Hrebesh M. Subhash

    6. Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Explore OSA | OSA Publishing Neurology
      Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 µm in tissue was achieved using a broad visible light spectrum (425 − 685 nm). Healthy human brain tissue was imaged to quantify the difference between white (WM) and grey matter (GM) in intensity and attenuation. The high axial resolution enables the investigation of amyloid-beta plaques of various sizes in human brain tissue and animal models of Alzheimer’s disease (AD). By performing a spectroscopic analysis of the OCM data, differences in the characteristics for WM, GM, and neuritic amyloid-beta plaques were found ...

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      Mentions: Christoph K. Hitzenberger Medical University of Vienna Bernhard Baumann

    7. Optical coherence tomography to guide percutaneous treatment of coronary bifurcation disease

      Explore Taylor & Francis Online Cardiology
      Optical coherence tomography to guide percutaneous treatment of coronary bifurcation disease

      Introduction : Cardiovascular disease remains the most common cause of death worldwide. Enormous progress in the technology and applicability of percutaneous techniques to treat obstructive coronary heart disease has been made, and the number of percutaneous coronary interventions (PCI) is increasing. Coronary bifurcations are involved in a substantial number of PCIs and despite recent advances, bifurcation PCI remains a challenge in terms of immediate success and long-term outcome. Angiography has a limited capacity for showing important features of the 3 dimensional coronary vessel anatomy, position of stent struts and exact wire positions and is therefore suboptimal for guiding bifurcation PCI. Intracoronary ...

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      Mentions: Oxford University

    8. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Explore OSA | OSA Publishing Gastroenterology , Probes
      Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 μm field of view and 5 μm transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe is 3.3 mm diameter and 20 mm rigid length, thus enabling passage through the endoscopic channel. The scanner has 1.8 kHz resonant frequency, and each volumetric acquisition takes ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    9. Postdoctoral Fellow: Biophotonics and Computer Vision Stanford University, Stanford, CA

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Fellow: Biophotonics and Computer Vision Stanford University, Stanford, CA

      The Stanford Biomedical Optics Group (http://sbo.stanford.edu), in close collaboration with clinical researchers in the School of Medicine (urology), seeks highly motivated research associate with excellent computer programming and image processing skills along with a good background / strong interest in optics, microscopy or medical imaging and interest or experience in computer vision. Stanford University provides an outstanding environment for solid technical research with clinical impact. Applicants will work closely with clinical collaborators and will spend a significant amount of time observing and guiding clinical research activities while working on a heavily computer vision programming-­‐oriented research project. Time ...

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      Mentions: Stanford University Audrey K. Ellerbee

    10. Optovue First in US to Receive FDA Clearance for Corneal Epithelial Thickness Mapping New Mapping Technique May be Early Indicator of Ocular Health

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Optovue First in US to Receive FDA Clearance for Corneal Epithelial Thickness Mapping New Mapping Technique May be Early Indicator of Ocular Health

      Optovue announced today that the U.S. Food and Drug Administration (FDA) has cleared the company’s epithelial thickness mapping software (epi-mapping) for quantitative measurements of the epithelial and stromal layers of the cornea. Epi-mapping is the first non-contact, quantitative method for corneal epithelia and stromal measurements, and it is the first and only FDA-cleared product indicated to provide corneal epithelia and stromal measurements that aid in the diagnosis, documentation and management of ocular health and diseases in the adult population. “The measurement of corneal epithelial thickness is becoming more recognized as a vital part of assessing patients for refractive ...

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      Mentions: Optovue Jay Wei FDA

    11. Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud

      Explore Circulation Cardiology
      Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud

      Background— Low endothelial shear stress (ESS) is associated with plaque progression and vulnerability. To date, changes in plaque phenotype over time in relation to ESS have not been studied in humans. The aim of this study was to investigate whether local ESS can predict subsequent changes to plaque phenotype using optical coherence tomography. Methods and Results— A total of 25 coronary arteries from 20 patients who underwent baseline and 6-month follow-up optical coherence tomography were included. Arteries were divided into serial 3-mm segments, and plaque characteristics were evaluated in each segment. A total of 145 segments were divided into low-ESS ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    12. Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

      Explore OSA | OSA Publishing Art
      Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

      his paper examines for the first time the potential complementary imaging capabilities of Optical coherence tomography (OCT) and non-linear microscopy (NLM) for multi-modal 3D examination of paintings following the successful application of OCT to the in situ, non-invasive examination of varnish and paint stratigraphy of historic paintings and the promising initial studies of NLM of varnish samples. OCT provides image contrast through the optical scattering and absorption properties of materials, while NLM provides molecular information through multi-photon fluorescence and higher harmonics generation (second and third harmonic generation). OCT is well-established in the in situ non-invasive imaging of the stratigraphy of ...

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      Mentions: Nottingham Trent University Haida Liang

    13. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      Explore arxiv.org Ophthalmology
      A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal & 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally stain (i.e. highlight) 6 tissue layers of the ONH. The accuracy of our algorithm was assessed (against manual segmentations) using the Dice coefficient, sensitivity, and specificity. We further studied ...

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      Mentions: Heidelberg Engineering Singapore Eye Research Institute National University of Singapore

    14. Intravascular imaging for characterization of coronary atherosclerosis

      Explore ScienceDirect Cardiology
      Intravascular imaging for characterization of coronary atherosclerosis

      This short review surveys recent developments in coronary intravascular imaging technologies. We present an outline of the applications of intravascular imaging for guidance of percutaneous coronary interventions and imaging of atherosclerosis, along with emerging clinical evidence for use. Imaging of tissue composition is important for understanding the relation between the presence of a lesion and clinical sequelae. We describe the recent innovations to enable imaging of unstable atherosclerotic plaques, focusing on the emergence of experimental multimodal imaging technology.

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      Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University

    15. Optical coherence tomography with nanoscale axial resolution using a laser-driven high-harmonic source

      Explore OSA | OSA Publishing
      Optical coherence tomography with nanoscale axial resolution using a laser-driven high-harmonic source

      Extreme ultraviolet microscopy is technologically demanding and thus largely confined to synchrotron radiation facilities. However, specific benefits like high resolution and exceptional material contrast provide strong motivation for the development of table-top alternatives. We report on the first demonstration of coherence tomography, i.e., noninvasive cross-sectional imaging, with high harmonics. A depth resolution of 24 nm and very good material contrast are achieved. Excessively demanding optics for extreme ultraviolet radiation are avoided and artifacts due to the elementary geometry are suppressed with a novel three-step one-dimensional phase-retrieval algorithm. The images are recorded in reflection geometry, facilitating the analysis of, e ...

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    16. From lab to clinic

      Explore Physics Today
      From lab to clinic

      Last month I visited my eye doctor, Harold Jacobson, for a routine checkup. After reading rows of ever-smaller letters, just as I had when my eyes were first tested in the 1970s, I asked him what new technology he was most excited about. “Optical coherence tomography,” he replied. “It’s a game changer!” Jacobson had bought an OCT scanner after my previous visit, so I got to see the game changer firsthand. As a patient, I briefly looked into a pair of eyepieces. As an ophthalmologist, Jacobson reviewed a wealth of information on the scanner’s screen. Beside cross sections ...

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      Mentions: Carmen A. Puliafito James G. Fujimoto Carl Zeiss Meditec

    17. Optical coherence tomography image-guided smart laser knife for surgery

      Explore Wiley Online Library
      Optical coherence tomography image-guided smart laser knife for surgery

      Background and Objective Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional surgical laser systems. Tm lasers provide superior beam quality, high volumetric tissue removal rates with minimal residual thermal footprint in tissue, enabling a reduction in unwanted damage to delicate adjacent sub-surface structures such as nerves or micro-vessels. We investigated such a combined Tm/OCT system with co-aligned imaging and cutting beams—a configuration ...

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      Mentions: Thomas E. Milner University of Texas at Austin

    18. Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Explore Wiley Online Library Dermatology , Oncology
      Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Background Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to ‚Standard’ OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. Objective Several factors may influence the quality of D-OCT imaging. Therefore, standard operating procedures as well as a common terminology are required for better validation and comparison of the images. Methods Here we present practical guidelines for optimal ...

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      Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen

    19. Real-time imaging adds interactive dimension to vitreoretinal surgery, training

      Explore Healio.com Ophthalmology
      Real-time imaging adds interactive dimension to vitreoretinal surgery, training

      First introduced in the early 1990s, OCT is a noninvasive imaging technique that obtains high-resolution, cross-sectional images of the retina and other ophthalmic tissues. In recent years, this technology has transitioned from being only available in the clinic to being able to be utilized in the operating room. Intraoperative OCT has allowed ophthalmologists to access real-time imaging of vitreoretinal surgery for the first time, adding a new dimension to surgery and education, according to a 2016 study published in Eye (London) by Justis P. Ehlers, MD. There are several FDA-approved systems with optional add-ons to improve performance. Companies such as ...

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      Mentions: Optovue Bioptigen Carl Zeiss Meditec

    20. Notal Vision Welcomes Roni Amiel as Chief Information Officer

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Notal Vision Welcomes Roni Amiel as Chief Information Officer

      Notal Vision, Ltd., a privately-held ophthalmic company focused on cloud-based, patient-activated, home telemonitoring technologies, is pleased to announce the appointment of Roni Amiel as Chief Information Officer (CIO). In this newly created position, Mr. Amiel will be responsible for advancing the Company's cloud-based technology and capabilities to expand their competitive advantage, and will report to Quinton Oswald , Chief Executive Officer of Notal Vision. "Drawing on his extensive information technology (IT) leadership and medical systems expertise, Roni will help us execute our strategic goals so that we can continue to deliver an outstanding patient and physician experience. Elevating this IT ...

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      Mentions: Notal Vision

    21. Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      Explore OSA | OSA Publishing Ophthalmology
      Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      High-resolution imaging of the human retina has always been a challenge due to imperfect optical properties of the human cornea and lens, which limit the achievable resolution. We present a noniterative digital aberration correction (DAC) to achieve aberration-free cellular-level resolution in optical coherence tomography (OCT) images of the human retina in vivo . The system used is a line-field spectral-domain OCT system with a high tomogram rate, reaching 2.5 kHz. Such a high speed enables us to successfully apply digital aberration correction for not only imaging of human cone photoreceptors but also to obtain an aberration- and defocus-corrected 3D volume ...

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      Mentions: Rainer A. Leitgeb Michael Pircher Medical University of Vienna

    22. Ph.D. Student Position in Optical Coherence Tomography at University of Basel in Switzerland

      Explore Optical Coherence Tomography News Jobs & Studentships
      Ph.D. Student Position in Optical Coherence Tomography at University of Basel in Switzerland

      The Department of Biomedical Engineering (DBE) has recently been awarded a Flagship project from the Werner Siemens Foundation (Zug/Switzerland). The principal aim of this interdisciplinary project called Minimally Invasive Robot Assisted Computer-guided LaserosteotomE (MIRACLE) is the development of a minimally invasive robotic endoscope for cutting bone with laser light. The successful PhD candidate will be part of an interdisciplinary team of biomedical engineers, mechatronics engineers, computer scientists, physicists, and medical doctors. He or she will be able to contribute to the development of a disruptive technology in robotic surgery. Topic Description In this project, the Ph.D. candidate will ...

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      Mentions: Siemens Azhar Zam

    23. Non-destructive analysis of flake properties in automotive paints with full-field optical coherence tomography and 3D segmentation

      Explore OSA | OSA Publishing NDE/NDT
      Non-destructive analysis of flake properties in automotive paints with full-field optical coherence tomography and 3D segmentation

      Automotive coating systems are designed to protect vehicle bodies from corrosion and enhance their aesthetic value. The number, size and orientation of small metallic flakes in the base coat of the paint has a significant effect on the appearance of automotive bodies. It is important for quality assurance (QA) to be able to measure the properties of these small flakes, which are approximately 10 μm in radius, yet current QA techniques are limited to measuring layer thickness. We design and develop a time-domain (TD) full-field (FF) optical coherence tomography (OCT) system to scan automotive panels volumetrically, non-destructively and without contact ...

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    24. Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Explore Circulation Cardiology
      Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Background —Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. Methods —Consecutive patients presenting with ST were prospectively enrolled in a registry using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT. Clinical data were collected according to a standardized protocol. OCT acquisitions were analyzed at a core laboratory. Dominant and contributing findings were adjudicated by an imaging ...

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      Mentions: Giulio Guagliumi Fernando Alfonso Kenichi Komukai
    25. See all articles

  3. Recent Articles From Around The Web

    1. Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis

      Explore Healio.com Ophthalmology
      Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis

      A 65-year-old man with diabetes and a history of fever of unknown origin 2 weeks earlier complained of sudden decreased vision in the left eye. The patient was diagnosed with bilateral West Nile virus (WNV) chorioretinitis associated with occlusive retinal vasculitis in the left eye. Swept-source optical coherence tomography angiography (SS-OCTA) of the left eye showed extensive, well-delineated, hypointense non-perfusion areas and perifoveal capillary arcade disruption in the superficial capillary plexus, as well as larger non-perfusion areas, capillary rarefaction, and diffuse capillary network attenuation and disorganization in the deep capillary plexus. OCTA may be a valuable tool for noninvasively assessing ...

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    2. Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma

      Explore LWW Online Ophthalmology
      Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma

      Retinal cavernous hemangioma is a rare, benign, retinal tumor characterized by angiomatous proliferation of vessels within the inner retina or the optic disc.1 Here we report a case of retinal cavernous hemangioma on the margin of the optic disc in the right eye of a 61-year-old asymptomatic female. The lesion was studied with multimodal imaging which included structural optical coherence tomography, fluorescein angiography, blue fundus auto-fluorescence, optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) and visual field examination. Blood circulation inside retinal cavernous hemangioma lesion is typically low-stagnant.2 However, OCTA demonstrated blood flow inside the ...

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      Mentions: Topcon Medical Systems

    3. Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography

      Explore Healio.com Ophthalmology
      Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography

      BACKGROUND AND OBJECTIVE: To compare patterns of choroidal hypoperfusion in white dot syndromes (WDS) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent white dot syndrome (MEWDS) were selected. This study was approved by the institutional review board at Massachusetts Eye and Ear. RESULTS: Unique patterns of choroidal ...

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      Mentions: Optovue

    4. Feature of the Week 08/17/2017: In Vivo Assessment of Periodontal Structures and Measurement of Gingival Sulcus with Optical Coherence Tomography: A Pilot Study

      Explore Optical Coherence Tomography News Dentistry
      Feature of the Week 08/17/2017: In Vivo Assessment of Periodontal Structures and Measurement of Gingival Sulcus with Optical Coherence Tomography: A Pilot Study

      There has been increasing interest on the development of clinically acceptable, more sensitive and specific methods for non-invasive diagnosis in Periodontics. In this pilot study, the performance of an Optical Coherence Tomography (OCT) system in imaging periodontal structures in humans was evaluated. Gingival sulcus depth measurements were obtained and compared with traditional probes. In total, 445 sites of 23 periodontally healthy individuals were measured by 3 instruments: North Carolina manual probe, Florida automated probe and OCT at 1325 nm. To obtain quantitative measurements from OCT images, the gingival refractive index was also determined. Discomfort/pain perception and the duration of ...

      Read Full Article
      Mentions: Anderson S. L. Gomes Federal University of Pernambuco Luana Osório Fernandes

    5. Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Explore Optical Coherence Tomography News Neurology , Funding
      Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex

      Massachusetts General Hospital Receives a 2017 NIH Grant for $474,273 for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex. The principal investigator is Anastasia Yendiki. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. The objective of the proposed research is to map the organization of human white matter (WM) with cutting-edge ex vivo imaging technologies. This work will produce microscopic-level information on several long-range WM projections, as well as a more targeted mapping of circuits that serve the prefrontal cortex (PFC). These circuits are of particular interest in ...

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      Mentions: National Institutes of Health Massachusetts General Hospital Harvard University

    6. LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      Explore Optical Coherence Tomography News Pulmonology , Funding
      LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients

      LX Medical Corporation Receives a 2017 NIH Grant for $223,403 for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients. The principal investigator is Andrei Vertikov. The program began in 2017 and ends in 2018. Below is a summary of the proposed work. Lung transplantation is increasingly used to treat patients with end-stage lung diseases. Complications frequently occur with chronic allograft rejection causing most of late morbidity and mortality in lung transplant recipients. Pathological manifestations of chronic rejection mostly affect small airways or bronchioles in the lung, often progressing undetected until the patient presents with an ...

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      Mentions: National Institutes of Health

    7. New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      New York University School of Medicine Receives a 2017 NIH Grant for $654,143 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2016 and ends in 2019. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of upmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project ...

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      Mentions: National Institutes of Health Joel S. Schuman

    8. University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core

      University of Alabama at Birmingham Receives a 2017 NIH Grant for $43,191 for Occular Phenotyping Core. The principal investigator is Timothy Kraft. A summary of the proposed work is given below. Non-invasive assessment of eye structure and function is essential to both basic and translational research in vision science. Widely used technologies include slit lamp for biomicroscopy of anterior and posterior segment, electroretinography (ERG, for massed retinal signal separable into components), optical coherence tomography (OCT) for display of layered tissues in posterior and anterior segments, imaging of the fundus via multiple modes of visualization (color, autofluorescence, dye-based angiography, infrared ...

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      Mentions: National Institutes of Health University of Alabama Bioptigen

    9. ROLE OF INTRA CORONARY IMAGING AND PHYSIOLOGY IN DIAGNOSIS AND MANAGEMENT OF CORONARY ARTERY DISEASE

      Explore Ayub Medical College, Abbottabad. Cardiology
      ROLE OF INTRA CORONARY IMAGING AND PHYSIOLOGY IN DIAGNOSIS AND MANAGEMENT OF CORONARY ARTERY DISEASE

      Coronary artery disease (CAD) is the leading cause of death in the Indo-Pakistan subcontinent as well as globally. Coronary angiography is considered the gold standard test for the diagnosis of CAD. Therefore, an accurate interpretation of coronary angiography is of paramount importance in decision-making to treat patients with CAD. Coronary angiography has the inherent limitation of being a two-dimensional X-Ray lumenogram of a complex three-dimensional vascular structure. Visual assessment of angiogram can lead to both inter- and intra-observer variability in the assessment of the severity and extent of the disease which can lead to differences in management strategies. This issue ...

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    10. Early detection of radiation maculopathy using OCTA imaging: a case report

      Explore Home - Springer Ophthalmology
      Early detection of radiation maculopathy using OCTA imaging: a case report

      Objective To report the case of a 62-year-old female treated with proton beam radiotherapy for a choroidal melanoma. Results After irradiation, the patient was followed-up regularly. Although clinical examination and spectral domain optical coherence tomography (OCT) showed no signs of radiation maculopathy, OCT angiography (OCTA) enabled detection of abnormalities (rarefaction of the vessel at both retinal capillary plexuses) probably related to the radiation maculopathy. Conclusion OCTA could help in the early detection of radiation maculopathy. This could be an important tool to monitor patients and discuss earlier treatments.

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      Mentions: Centre Hospitalier Intercommunal de Créteil

    11. Optical sectioning in induced coherence tomography with frequency-entangled photons

      Explore arxiv.org
      Optical sectioning in induced coherence tomography with frequency-entangled photons

      We demonstrate an experimental configuration to perform optical sectioning of a sample based on the concept of induced coherence [Zou et al., Phys. Rev. Lett. 67, 3187 (1991)]. This can be viewed as a new type of optical coherence tomography scheme, where different reflectivities of the sample under study translates into changes of the degree of first-order coherence between two beams. The induced coherence tomography scheme proposed here uses frequency-entangled photons embedded in a nonlinear interferometer. As practical advantage the scheme allows probing the sample with one wavelength and measuring light with another wavelength. In a bio-imaging scenario, this would ...

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    12. Optical coherence tomography imaging of cranial meninges post brain injury in vivo

      Explore OSA | OSA Publishing
      Optical coherence tomography imaging of cranial meninges post brain injury in vivo

      We report a new application of optical coherence tomography (OCT) to investigate the cranial meninges in an animal model of brain injury in vivo. The injury is induced in a mouse due to skull thinning, in which the repeated and excessive drilling exerts mechanical stress on the mouse brain through the skull, resulting in acute and mild brain injury. Transcranial OCT imaging reveals an interesting virtual space between the cranial meningeal layers post skull thinning, which is gradually closed within hours. The finding suggests a promise of OCT as an effective tool to monitor the mechanical trauma in the small ...

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      Mentions: University of Washington Ruikang K. Wang Woo June Choi

    13. Two-year Results after Deep Sclerectomy with Non-absorbable Uveoscleral Implant (Esnoper-Clip): Surgical Area Analysis Using Anterior-segment Optical Coherence Tomography

      Explore LWW Online Ophthalmology
      Two-year Results after Deep Sclerectomy with Non-absorbable Uveoscleral Implant (Esnoper-Clip): Surgical Area Analysis Using Anterior-segment Optical Coherence Tomography

      Purpose: To report two years results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics. Alava, Spain), a non-absorbable hema implant, and the morphological analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). Methods: Forty-one eyes of 41 patients with medically uncontrolled open angle glaucoma (OAG) who underwent DS with the uveoscleral implant were included in this prospective interventional study. Patients were recruited and selected sequentially. All patients were followed at least for 12 months and 36 of them for 24 months. Absolute success was defined as IOP <=18 mmHg and >=20 ...

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      Mentions: Zeiss Visante OCT

    14. Depth-resolved local reflectance spectra measurements in full-field optical coherence tomography

      Explore OSA | OSA Publishing
      Depth-resolved local reflectance spectra measurements in full-field optical coherence tomography

      Full-field optical coherence tomography (FF-OCT) is a widely used technique for applications such as biological imaging, optical metrology, and materials characterization, providing structural and spectral information. By spectral analysis of the backscattered light, the technique of spectroscopic-OCT enables the differentiation of structures having different spectral properties, but not the determination of their reflectance spectrum. For surface measurements, this can be achieved by applying a Fourier transform to the interferometric signals and using an accurate calibration of the optical system. An extension of this method is reported for local spectroscopic characterization of transparent samples and in particular for the determination of ...

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    15. Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma

      Explore IOVS Journal Ophthalmology
      Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma

      Purpose : A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods : Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations. The Wilcoxon rank sum test was applied to test correlation R , root mean square error (RMSE ...

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      Mentions: Michael D. Abràmoff Heidelberg Spectralis University of Iowa
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