1. Recent Articles From Around The Web

    1. Distortion and Instability Compensation with Deep Learning for Rotational Scanning Endoscopic Optical Coherence Tomography

      Distortion and Instability Compensation with Deep Learning for Rotational Scanning Endoscopic Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is increasingly used in endoluminal procedures since it provides high-speed and high resolution imaging. Distortion and instability of images obtained with a proximal scanning endoscopic OCT system are significant due to the motor rotation irregularity, the friction between the rotating probe and outer sheath and synchronization issues. On-line compensation of artefacts is essential to ensure image quality suitable for real-time assistance during diagnosis or minimally invasive treatment. In this paper, we propose a new online correction method to tackle both B-scan distortion, video stream shaking and drift problem of endoscopic OCT linked to A-line level image ...

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    2. Laser-induced choroidal neovascularization detected on optical coherence tomography angiography in patients with diabetic retinopathy

      Laser-induced choroidal neovascularization detected on optical coherence tomography angiography in patients with diabetic retinopathy

      Purpose To report two cases of laser-induced choroidal neovascularization (CNV) using swept source optical coherence tomography (SS-OCTA) imaging in patients with proliferative diabetic retinopathy. Observations Two patients developed CNV adjacent to laser scars, and these neovascular lesions were detected on SS-OCTA imaging. Historically, both patients had subretinal fluid associated with these lesions. Visual acuity for both patients was 20/25 in the affected eyes. Both patients were observed over multiple years with stable CNV and visual acuity. Conclusions and importance SS-OCTA was able to detect laser-induced CNV in a rapid and non-invasive manner. When there is no foveal involvement and ...

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    3. Optical coherence tomography- angiography: A new diagnostic and follow-up tool for glaucoma

      Optical coherence tomography- angiography: A new diagnostic and follow-up tool for glaucoma

      Glaucoma is an optic neuropathy and is one of the leading causes of irreversible vision loss worldwide. There are studies on the role of vascular dysfunction in the pathogenesis of glaucoma. Evaluation of intraocular blood flow will be useful in elucidating the pathogenesis. Various techniques are available for the diagnosis and follow-up of patients with glaucoma. Optical coherence tomography angiography (OCTA) has emerged as a new technology to detect the vascular effects of the glaucoma. Optical coherence tomography angiography (OCTA) is a new technology and many publications have been made in the field of glaucoma. In this article, we aimed ...

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    4. Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy

      Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy

      The purpose of this study was to evaluate corneal irregular astigmatism of patients with granular and lattice corneal dystrophy (GCD and LCD). 70 GCD, 35 LCD, and 23 control eyes were included. Anterior and posterior corneal topographic data obtained from anterior segment optical coherence tomography were expanded into four components via Fourier harmonic analysis. These components were compared with healthy eyes and the association between each component and best-corrected visual acuity (BCVA) was investigated. Anterior and posterior components increased in LCD eyes, but none increased in GCD. Posterior components of GCD type 2 (GCD2), anterior and posterior of LCD type ...

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    5. Early-term Optical Coherence Tomography Angiographic Findings in Pediatric Patients Infected with COVID-19

      Early-term Optical Coherence Tomography Angiographic Findings in Pediatric Patients Infected with COVID-19

      Purpose: The aim of this study was to investigate possible vascular changes in pediatric patients infected with COVID-19 and to compare these with an age-matched control group. Methods: All patients underwent an ocular assessment and optical coherence tomography angiography examination. Two vascular networks were analyzed as the superficial and deep regions. Results: Evaluation was made of 40 eyes of 20 patients who had recently recovered from COVID infection and 80 eyes of 40 healthy individuals. The DCP-VD values of the COVID group were significantly lower than the control group in most quadrants. The FAZ PERIM and FAZ area values in ...

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    6. Integrated deep learning framework for accelerated optical coherence tomography angiography

      Integrated deep learning framework for accelerated optical coherence tomography angiography

      Label-free optical coherence tomography angiography (OCTA) has become a premium imaging tool in clinics to obtain structural and functional information of microvasculatures. One primary technical drawback for OCTA, however, is its imaging speed. The current protocols require high sampling density and multiple acquisitions of cross-sectional B-scans to form one image frame, resulting in low acquisition speed. Recently, deep learning (DL)-based methods have gained attention in accelerating the OCTA acquisition process. They achieve faster acquisition using two independent reconstructing approaches: high-quality angiograms from a few repeated B-scans and high-resolution angiograms from undersampled data. While these approaches have shown promising results ...

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    7. The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy

      The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy

      Diabetic retinopathy is an increasingly common complication of diabetes mellitus that benefits from early diagnosis and frequent monitoring, especially in pregnancy where there is a greater risk of progression. Fundus fluorescein angiography is currently the gold standard method of investigation for neovascularization. However, this has risks of unpleasant and potentially dangerous side effects, with an added theoretical risk to the fetus in pregnancy. Wide-field optical coherence tomography angiography (PLEX Elite 9000, Carl Zeiss Meditec, Inc. USA and DRI Swept Source OCT Triton, Topcon Medical Systems, Inc. USA) potentially offers a safer, faster and equally effective alternative method for diagnosis and ...

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    8. Automatic Assessment of Calcified Plaque and Nodule by Optical Coherence Tomography Adopting Deep Learning Mode

      Automatic Assessment of Calcified Plaque and Nodule by Optical Coherence Tomography Adopting Deep Learning Mode

      Significance: Detection and characterization of coronary atherosclerotic plaques often need reviews of a large number of optical coherence tomography (OCT) imaging slices to make a clinical decision. However, it is a challenge to manually review all the slices and consider the interrelationship between adjacent slices. Approach : Inspired by the recent success of deep convolutional network on the classification of medical images, we proposed a ResNet-3D network for classification of coronary plaque calcification in OCT pullbacks. The ResNet-3D network was initialized with a trained ResNet-50 network and a three-dimensional convolution filter filled with zeros padding and non-zeros padding with a convolutional ...

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    9. Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity

      Capillary density and caliber as assessed by optical coherence tomography angiography may be significant predictors of diabetic retinopathy severity

      Purpose To validate retinal capillary density and caliber associations with diabetic retinopathy (DR) severity in different clinical settings. Methods This cross-sectional study assessed retinal capillary density and caliber in the superficial retinal layer of 3-mm OCTA scans centered on the fovea. Images were collected from non-diabetic controls and subjects with mild or referable DR (defined DR worse than mild DR) between February 2016 and December 2019 at secondary and tertiary eye care centers. Vessel Skeleton Density (VSD), a measure of capillary density, and Vessel Diameter Index (VDI), a measure of vascular caliber, were calculated from these images. Discriminatory performance of ...

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    10. Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

      Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

      Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group ( p = 0.044). Average retinal thickness and foveal ...

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    11. Neuro-ophthalmological evaluation including optical coherence tomography surrounding venous sinus stenting in idiopathic intracranial hypertension with papilledema: a case series

      Neuro-ophthalmological evaluation including optical coherence tomography surrounding venous sinus stenting in idiopathic intracranial hypertension with papilledema: a case series

      Venous sinus stenting (VSS) for idiopathic intracranial hypertension (IIH) has been demonstrated to achieve significant symptom improvement while harboring a low periinterventional morbidity profile. Comprehensive neuro-ophthalmological monitoring represents a cornerstone of disease monitoring. The value of optical coherence tomography (OCT) requires further exploration. Patients with IIH and papilledema who underwent VSS between 04/2018 and 02/2021 were retrospectively reviewed. Clinical and radiological were analyzed. Neuro-ophthalmological data included visual acuity, visual fields, fundoscopy categorized via Frisén scale, and OCT obtained retinal nerve fiber layer (RNFL) thickness were analyzed. Of 39 IIH patients who underwent cerebral angiography with transverse-sigmoid sinus ...

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    12. Association of prediabetes with retinal microvasculature on swept-source optical coherence tomography angiography in the elderly

      Association of prediabetes with retinal microvasculature on swept-source optical coherence tomography angiography in the elderly

      Aims: To investigate the retinal microvasculature in the elderly persons with prediabetes mellitus (preDM) and type 2 DM. Methods: This cross-sectional study included a total of 452 eyes without retinal pathologies of 301 elderly volunteers aged ≥65 years, and they were categorized into nonDM (225 eyes), preDM (177 eyes), and DM (50 eyes) groups based on their HbA1c. Fundus photography, swept-source optical coherence tomography and angiography, and comprehensive systemic examinations were conducted. Vessel density (VD) and foveal avascular zone (FAZ) in superficial and deep retinal microvasculature were investigated for their association with DM stages using linear mixed model. Results: Superficial ...

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    13. The Role of Optical Coherence Tomography Angiography in Detecting and Monitoring Inflammatory Choroidal Neovascularization

      The Role of Optical Coherence Tomography Angiography in Detecting and Monitoring Inflammatory Choroidal Neovascularization

      Purpose: To investigate the utility of optical coherence tomography angiography (OCTA) for the detection of inflammatory choroidal neovascularization (iCNV) and monitoring their response to treatment. Methods: A retrospective review of patients with a diagnosis of uveitis and associated iCNV with active exudation was performed. Active iCNV was determined by spectral domain-OCT and/or fluorescein angiogram. Spectral domain-OCTA outer retina to choriocapillaris (ORCC) slabs were evaluated for the presence of iCNV. Follow-up OCTA images were qualitatively assessed to determine if regression of iCNV occurred following treatment. Results: Thirteen eyes of 12 patients were included. The etiologies of uveitis included punctate inner ...

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    14. Pachychoroid spectrum disease and choriocapillary flow analysis in patients with Cushing disease: an optical coherence tomography angiography study

      Pachychoroid spectrum disease and choriocapillary flow analysis in patients with Cushing disease: an optical coherence tomography angiography study

      Purpose: To investigate the presence of pachychoroid spectrum disease (PSD) in patients with Cushing disease (CD) and to evaluate subfoveal choroidal thickness (SFCT) and choriocapillary flow using spectral domain OCT (SD-OCT) with the enhanced depth imaging (EDI) and optical coherence tomography angiography (OCT-A). Methods: Thirty-two patients with CD and 32 age- and sex-matched healthy volunteers were enrolled in this observational study. All participants had a complete ophthalmic examination including SD-OCT with EDI and OCT-A, and were subjected to the Perceived Stress Scale test (PSS). All patients with CD had hormone test including 24-h urinary-free cortisol (UFC) and plasma adrenocorticotropic hormone ...

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    15. Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review

      Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review

      Background: Diabetic retinopathy (DR) is the leading cause of legal blindness in the working population in developed countries. Optical coherence tomography (OCT) angiography (OCTA) has risen as an essential tool in the diagnosis and control of diabetic patients, with and without DR, allowing visualisation of the retinal and choroidal microvasculature, their qualitative and quantitative changes, the progression of vascular disease, quantification of ischaemic areas, and the detection of preclinical changes. The aim of this article is to analyse the current applications of OCTA and provide an updated overview of them in the evaluation of DR. Methods: A systematic literature search ...

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  4. Picture Gallery

    Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography 4 year funded PhD studentship in Dental OCT at University College London Longitudinal Morphological and Functional Characterization of Human Heart Organoids Using Optical Coherence Tomography Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study Researchers pilot 'itty bitty' device for earlier ovarian cancer detection Distortion and Instability Compensation with Deep Learning for Rotational Scanning Endoscopic Optical Coherence Tomography Laser-induced choroidal neovascularization detected on optical coherence tomography angiography in patients with diabetic retinopathy Optical coherence tomography- angiography: A new diagnostic and follow-up tool for glaucoma Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy Early-term Optical Coherence Tomography Angiographic Findings in Pediatric Patients Infected with COVID-19 Integrated deep learning framework for accelerated optical coherence tomography angiography The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu