1. Recent Articles From Around The Web

    1. Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

      Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

      We demonstrated FF OCM(full field optical coherence microscopy) using an ultrathin forward-imaging SMMF (short multimode fiber) probe of 50 μm core diameter, 125 μm diameter, and 7.4 mm length, which is a typical graded-index multimode fiber for optical communications. The axial resolution was measured to be 2.20 μm, which is close to the calculated axial resolution of 2.06 μm. The lateral resolution was evaluated to be 4.38 μm using a test pattern. Assuming that the FWHM of the contrast is the DOF (depth of focus), the DOF of the signal is obtained at 36 μm ...

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    2. High frame-rate en face optical coherence tomography system using KTN optical beam deflector

      High frame-rate en face optical coherence tomography system using KTN optical beam deflector

      We developed high frame-rate en face optical coherence tomography (OCT) system using KTa 1-x Nb x O 3 (KTN) optical beam deflector. In the imaging system, the fast scanning was performed at 200 kHz by the KTN optical beam deflector, while the slow scanning was performed at 800 Hz by the galvanometer mirror. As a preliminary experiment, we succeeded in obtaining en face OCT images of human fingerprint with a frame rate of 800 fps. This is the highest frame-rate obtained using time-domain (TD) en face OCT imaging. The 3D-OCT image of sweat gland was also obtained by our imaging ...

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    3. Speckle variance optical coherence tomography using an SS-OCT system and an extended k-sampling clock

      Speckle variance optical coherence tomography using an SS-OCT system and an extended k-sampling clock

      is vacant or filled with material having a refractive index different from the tissue, the observed structure is deformed significantly. This deformation artifact can be minimized by filling the cavity with liquid having a refractive index nearly equal to the tissue. Furthermore, by using dynamical OCT method, cavity image intensity can be significantly enhanced compared with the tissue. This image contrast improvement may allow imaging of cavity structures inside deep in tissues. In this paper, we demonstrate good contrast of speckle variance OCT imaging of phantoms. A trial of deep OCT imaging is introduced with which we can extend the ...

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    4. Master/slave: the ideal tool for coherence revival based optical coherence tomography imaging instruments

      Master/slave: the ideal tool for coherence revival based optical coherence tomography imaging instruments

      In this communication, we present the utility of the Master/Slave (MS) method in combination with the coherence revival technique to obtain full axial range Optical Coherence Tomography (OCT) cross-section images. The MS method eliminates two major drawbacks of the conventional Fourier Transformed (FT) based OCT technology when applied to the coherence revival technique: the need of data re-sampling as well as the need to compensate for unbalanced dispersion in the interferometer.

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    5. Ultralong-range optical coherence tomography-based angiography by akinetic swept source

      Ultralong-range optical coherence tomography-based angiography by akinetic swept source

      Most of current OCT-based angiography suffers from small FOV with short imaging range. Here we implement an ultralong-range OCT system for vascular imaging based on an akinetic swept source. This swept-source OCT (SS-OCT) system enables us to achieve up to 46 mm long imaging range with unprecedented roll-off performance. To compare with traditional spectral domain OCT (SD-OCT) system, we demonstrated the vascular imaging of the entire mice brain with wide FOV by this ultralong-range SS-OCT system and captured the blood flow images at different depth position, which shows the great advantages and bright future of this ultralong-range SS-OCT in vascular ...

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    6. Dual-beam angular compounding for speckle reduction in optical coherence tomography

      Dual-beam angular compounding for speckle reduction in optical coherence tomography

      Optical coherence tomography (OCT), as a low-coherence interferometric imaging technique, inevitably suffers from speckle noise, which can reduce image quality and signal-to-noise (SNR). In this paper, we present a dual-beam angular compounding method to reduce speckle noise and improve SNR of OCT image. Two separated parallel light beams are created on the sample arm using a 1x2 optical fiber coupler and are focused into samples at different angles. The epi-detection scheme creates three different light path combinations of these two light beams above. The three combinations produce three images in single B-scan, which are completely separated in depth. The three ...

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    7. Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Optical Coherence Tomography (OCT) offers real-time high-resolution three-dimensional images of tissue microstructures. In this study, we used OCT skin images acquired from ten volunteers, neither of whom had any skin conditions addressing the features of their anatomic location. OCT segmented images are analyzed based on their optical properties (attenuation coefficient) and textural image features e.g., contrast, correlation, homogeneity, energy, entropy, etc. Utilizing the information and referring to their clinical insight, we aim to make a comprehensive computational model for the healthy skin. The derived parameters represent the OCT microstructural morphology and might provide biological information for generating an atlas ...

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    8. High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

      High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

      In this study, we developed and applied highly-scattering large gold nanorods (LGNRs) and custom spectral detection algorithms for high sensitivity contrast-enhanced optical coherence tomography (OCT). We were able to detect LGNRs at a concentration as low as 50 pM in blood. We used this approach for noninvasive 3D imaging of blood vessels deep in solid tumors in living mice. Additionally, we demonstrated multiplexed imaging of spectrally-distinct LGNRs that enabled observations of functional drainage in lymphatic networks. This method, which we call MOZART, provides a platform for molecular imaging and characterization of tissue noninvasively at cellular resolution

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    9. Gold nanoparticles evaluation using functional optical coherence tomography

      Gold nanoparticles evaluation using functional optical coherence tomography

      The main object of this research was to assess the ability to characterize the gold nanoparticles using optical modalities like optical coherence tomography. Since the nanoparticles, especially gold one, have been very attractive for medical diagnosis and treatment the amount of research activities have been growing rapidly. The nanoparticles designed for different applications like contrast agents or drugs delivery change the optical features of tissue in different way. Therefore, the expanded analysis of scattering optical signal may lead to obtain much more useful information about the tissues health and the treatment efficiency. The noninvasive measurements of the concentration and distribution ...

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    10. High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      We propose a maximum a-posteriori (MAP) intensity estimator to improve the image contrast of polarization diversity (PD)-OCT imaging to achieve high contrast polarization-artifact-free images. The MAP estimator compensates for the inevitable reduction of signal-to-noise ratio (SNR) in PD-OCT caused by the splitting of power into two polarization detection channels. It also has low noise-offset in low intensity regions such as the vitreous. This method is applied to posterior eye images, and shows high-contrast, polarization-artifact-free images. This method also enables attenuation coefficient imaging with finer differentiation of attenuation levels.

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    11. Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal imaging systems that combine scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) have demonstrated the utility of concurrent en face and volumetric imaging for aiming, eye tracking, bulk motion compensation, mosaicking, and contrast enhancement. However, this additional functionality trades off with increased system complexity and cost because both SLO and OCT generally require dedicated light sources, galvanometer scanners, relay and imaging optics, detectors, and control and digitization electronics. We previously demonstrated multimodal ophthalmic imaging using swept-source spectrally encoded SLO and OCT (SS-SESLO-OCT). Here, we present system enhancements and a new optical design that increase our SS-SESLO-OCT data throughput ...

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    12. Classification of human ovarian tissue using full field optical coherence tomography

      Classification of human ovarian tissue using full field optical coherence tomography

      The feasibility of a full-field optical coherence tomography (FFOCT) system for rapid wide field optical analysis of normal and malignant human ovarian tissue pathologies was demonstrated. Five features were extracted from the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples.

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    13. Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

      Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

      Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at ~1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of ~10 nanometers, the proposed 4D ...

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    14. Design and optimization of a miniaturized imaging probe for simultaneous endomicroscopy and optical coherence tomography

      Design and optimization of a miniaturized imaging probe for simultaneous endomicroscopy and optical coherence tomography

      A highly-integrated MEMS-based bimodal probe design with integrated piezoelectric fiber scanner for simultaneous endomicroscopy and optical coherence tomography (OCT) is presented. The two modalities rely on spectrally-separated optical paths that run partially in parallel through a micro-optical bench system, which has dimensions of only 13 x 2 x 3mm 3 (l x w x h). An integrated tubular piezoelectric fiber scanner is used to perform en face scanning required for three dimensional OCT measurements. This scanning engine has an outer diameter of 0.9mm and a length of 9mm, and features custom fabricated 10 μm thick polyimide flexible interconnect lines ...

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    15. Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample to study the correlation between PS-OCT and SHG microscopy. Qualitative conjecture has been made that the phase retardation measured by PS-OCT is affected by the relationship between the collagen fiber ...

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  2. Organizations in the News

    1. (3 articles) Vanderbilt University
    2. (3 articles) University of Washington
    3. (2 articles) Center for Ophthalmic Optics and Lasers
    4. (2 articles) Stanford University
    5. (2 articles) Medical University of Vienna
    6. (2 articles) University of Cyprus
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    8. (2 articles) ESPCI ParisTech
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  3. People in the News

    1. (3 articles) Yuankai K. Tao
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    3. (2 articles) Eric A. Swanson
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    13. (2 articles) Costas D. Pitris
    14. (1 articles) Joel Ramjist
    15. (1 articles) Stephen A. Boppart
  4. OCT Companies in the News

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  5. Picture Gallery

    Review of intraoperative optical coherence tomography: technology and applications [Invited] The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited] The 2017 Fritz J. and Dolores H. Russ Prize Presentation Honoring Visionary Engineers for the Exceptional Bioengineering Achievement of Developing Optical Coherence Tomography Wasatch Photonics Unleashes Game Changing Spectral-domain OCT Spectrometer Optical coherence tomography-integrated, wearable (backpack-type), compact diagnostic imaging modality for in situ leaf quality assessment Computational optical coherence tomography [Invited] History of Intraoperative OCT Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia Dermoscopy guided dark-field multi-functional optical coherence tomography
  6. Recent Quotes

    1. It's the most rapidly adopted ophthalmic technology in history.
      By Joel S. Schuman
    2. Our OCT Angiography congresses is a major force in promoting the transition from FA to OCTA by educating the ophthalmologists .
      By Bruno Lumbroso
    3. The development of OCT in the early 1990s greatly benefited from components and methods used in fiber-optical communications...And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    4. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    5. Our study demonstrates world-record results in cubic meter volume imaging, with at least an order of magnitude larger depth range and volume compared to previous demonstrations of three-dimensional OCT...These results provide a proof-of-principle demonstration for using OCT in this new regime...Long-range OCT is a new range of operation that requires extremely high performance light sources, integrated optical receivers and signal processing.
      By James G. Fujimoto
    6. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    7. "The development of OCT in the early 1990s greatly benefited from components and methods used in fiber optical communications,. And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    8. OCT has revolutionized the treatment of eye disease on a global basis and it is now routinely used to make clinical decisions in treating patients with blinding eye diseases...I’ve been honored to be part of the team that created this technology and to know our creation has improved diagnosis and treatment for millions of eye patients around the world.
      By Carmen A. Puliafito
    9. We believe strongly that our MRO™ sub-dermal fingerprint technology can play a key role in addressing the presentation attack problem by providing an effective deployable solution.
      By Don Bogue
    10. Today, interdisciplinary research in biomedical optics is the standard. “And that was less common 25 years ago. A lot of innovation happens at the boundaries of disciplines. OCT is such a rich combination of disciplines—in optics, mechanical systems, electronics, software, medical devices, clinical medicine. That’s one of the reasons there’s been so much innovation in OCT, and that there’s so much more to come.
      By Eric A. Swanson