1. Recent Articles From Around The Web

    1. The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

      The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy

      Purpose : Histologic details of progression routes to geographic atrophy (GA) in AMD are becoming available through optical coherence tomography (OCT). We studied the origins and evolution of an OCT signature called plateau in eyes with GA and suggested a histologic correlate. Methods : Serial eye-tracked OCT scans and multimodal imaging were acquired from eight eyes of seven patients with GA and plateau signatures over a mean follow-up of 7.7 years (range, 3.7–11.6). The histology of unrelated donor eyes with AMD was reviewed. Results : Drusenoid pigment epithelial detachment (PED) on OCT imaging progressed into wide-based mound-like signatures with ...

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    2. Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography

      Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography

      Purpose To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT). Methods A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and human were used to demonstrate its feasibility. For porcine eyes, the probe imaged the CCE by accessing the region of the aqueous plexus (AP) as well as along the inner ...

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    3. Imaging system, method and distal attachment for multidirectional field of view endoscopy

      Imaging system, method and distal attachment for multidirectional field of view endoscopy

      An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second radiation. The first radiation can impact at least one first portion of the anatomical structure(s), and the second radiation can ...

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    4. System for eye examination by means of stress-dependent parameters

      System for eye examination by means of stress-dependent parameters

      The present disclosure relates to a system for examining an eye. The system comprises a microscopy system for generating an image plane image of an object region. An OCT system of the system is configured to acquire OCT data from the object region which reproduce the object region in different stress states. A data processing unit of the system is configured to determine at least one value of a stress-dependent parameter, depending on the OCT data. The system generates an output image that is dependent on the image plane image and is furthermore dependent on the stress-dependent parameter.

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    5. Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography

      Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography

      Exemplary embodiments of the present disclosure include apparatus and methods for identifying bright spot indications observed through optical coherence tomography. The indications can be evaluated, for example, to link risk factors or other conditions to clinically relevant outcomes

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    6. Avinger’s Pantheris Named a 2017 Gold Edison Award Winner

      Avinger’s Pantheris Named a 2017 Gold Edison Award Winner

      Avinger, Inc., a leading developer of innovative treatments for peripheral artery disease (PAD), was honored at the 2017 Edison Awards™ in the Medical/Dental Surgical Tool category with gold for Pantheris, the first-ever image-guided atherectomy device for the treatment of PAD. Avinger was nominated among hundreds of the world’s most recognized companies to acknowledge dedication and commitment of innovation to create a positive impact in the world. The ballot of nominees for the Edison Awards was judged by a panel of more than 3,000 leading business executives including past award winners, academics and leaders in the fields of ...

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    7. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography

      Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography

      Purpose To quantitatively evaluate the retinal microvasculature in human subjects with retinal venous occlusions (RVO) using optical coherence tomography angiography (OCTA). Design Retrospective, cross-sectional, observational case series. Participants Sixty subjects (84 eyes) were included (20 BRVO, 14 CRVO, 24 unaffected fellow eyes, and 26 controls). Methods OCTA was performed on a prototype, spectral domain-OCTA system in the 3x3mm central macular region. Custom software was used to quantify morphology and density of retinal capillaries using four quantitative parameters. The vasculature of the segmented retinal layers and nonsegmented whole retina were analyzed. Main outcome measures Fractal dimension (FD), vessel density (VD), skeletal ...

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    8. Parapapillary Choroidal Microvasculature Dropout in Glaucoma A Comparison between Optical Coherence Tomography Angiography and Indocyanine Green Angiography

      Parapapillary Choroidal Microvasculature Dropout in Glaucoma  A Comparison between Optical Coherence Tomography Angiography and Indocyanine Green Angiography

      Purpose To investigate whether the parapapillary choroidal microvasculature dropout (MvD) determined by optical coherence tomography angiography (OCTA) in glaucomatous eyes indicates a true perfusion defect and whether the MvD accurately represents the area of nonperfusion. Design Observational case series. Participants Thirty primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by OCTA and 13 POAG patients without this dropout. Methods Peripapillary circulation was evaluated using both OCTA and indocyanine green angiography (ICGA). For OCTA, the choroidal microvasculature was evaluated using 4.5×4.5-mm choroid–disc vessel density maps of OCTA images of the optic nerve head. An MvD ...

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    9. In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors

      In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors

      Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques. However, since most protein biomarkers do not exhibit inherent contrast detectable by OCT, exogenous contrast agents must be employed for imaging specific cellular biomarkers of interest. While a number of OCT contrast agents have been previously studied, demonstrations of molecular targeting with such agents in live animals have been historically challenging and notably limited in success. Here we demonstrate for the first time that microbeads (µBs) can be used as contrast agents to target cellular ...

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    10. Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

      Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

      In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared ...

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    11. Application of wearable optical coherence tomography (OCT) and Loop-mediated isothermal amplification (LAMP) techniques for In situ real-time field inspection of apple Marssonina blotch disease

      Application of wearable optical coherence tomography (OCT) and Loop-mediated isothermal amplification (LAMP) techniques for In situ real-time field inspection of apple Marssonina blotch disease

      Here we describe the possible application of optical coherence tomography (OCT) to inspect Marssonina coronaria infected apple blotch disease of in situ apple leaves. To fulfill the in situ field inspection requirement, we developed a compact wearable OCT system. For the confirmation of OCT results, simultaneous experiment was performed in realtime using loop-mediated isothermal amplification (LAMP), which is frequently used in agriculture. LAMP method was developed as an alternative approach for the inspection of disease. We performed field inspection for 30 consecutive days, and all the acquired results from both OCT and lamp were compared to confirm the correlation. A ...

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    12. A 3.4-mm beam diameter system for retinal imaging with OCT and adaptive optics

      A 3.4-mm beam diameter system for retinal imaging with OCT and adaptive optics

      We present an adaptive-optics optical coherence tomography (AO-OCT) system with 3.4-mm beam diameter. A deformable mirror is used for the correction of two radial Zernike orders (defocus, vertical and oblique astigmatism). The aberrations are corrected sequentially with a Shack-Hartmann wave-front sensor and the deformable mirror. This system fills a gap between a standard clinical 1.2-mm beam diameter OCT system and a 6-mm beam diameter AO-OCT system. We also present 8° by 8° en face OCT images from a patient with macular degeneration. This system has a 25 cm by 50 cm footprint, which makes it considerably smaller to ...

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      Mentions: Barry Cense
    13. Observation of elastic wave propagation near tissue surface using swept-source optical coherence tomography

      Observation of elastic wave propagation near tissue surface using swept-source optical coherence tomography

      Dynamic optical coherence elastography (OCE) is expected as new diagnostic technology of near tissue surface. However, few studies about shear wave propagation in inhomogeneous medium have been reported although human tissue is inhomogeneous medium. In this report, estimation of shear wave speeds and strain images of inhomogeneous medium were studied using swept-source optical coherence tomography (SS-OCT) system. Firstly, the shear wave speeds of four-layered chicken sample were measured. Secondly, OCT images of tissue mimicking phantoms, which included thread and aluminum wire were measured and strain distributions were calculated by PIV. Reflection and artifact of strain images were discussed.

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    14. Noninvasive imaging of oral mucosae with optical coherence tomography

      Noninvasive imaging of oral mucosae with optical coherence tomography

      In this study, a swept-source optical coherence tomography (OCT) system is developed for in vivo visualization of structural and vascular morphology oral mucosa. For simplification of optical probe fabrication, probe weight, and system setup, the body of the scanning probe is fabricated by a 3D printer to fix the optical components and the mechanical scanning device, and a partially reflective slide is attached at the output end of probe to achieve a common-path configuration. Aside from providing the ability of 3D structural imaging with the developed system, 3D vascular images of oral mucosa can be simultaneously obtained. Then, different locations ...

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    15. Dual illumination for cornea and retina imaging using spectral domain optical coherence tomography

      Dual illumination for cornea and retina imaging using spectral domain optical coherence tomography

      A dual illumination system is proposed for cornea and retina imaging using spectral domain optical coherence tomography (SD-OCT). The system is designed to acquire cornea and retina imaging with dual illumination with limited optics and using a single spectrometer. The beam propagation for cornea and retina imaging in dual illumination enables to acquire the images of different segments. This approach will reduce the imaging time for separate corneal and retinal imaging. The in vivo imaging of both the cornea and retina of a health volunteer shows the feasibility of the system for clinical applications.

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  2. Organizations in the News

    1. (3 articles) Chang Gung University
    2. (2 articles) Kyungpook National University
    3. (2 articles) University of Southern California
    4. (2 articles) University of Washington
    5. (2 articles) Nanjing University of Science and Technology
    6. (1 articles) Tokyo Institute of Technology
    7. (1 articles) University of Pennsylvania
    8. (1 articles) Harbin Medical University
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  3. People in the News

    1. (3 articles) K. Bailey Freund
    2. (3 articles) Meng-Tsan Tsai
    3. (2 articles) Ruikang K. Wang
    4. (2 articles) Barry Cense
    5. (2 articles) Jeehyun Kim
    6. (2 articles) Wanrong Gao
    7. (1 articles) Anselm Kampik
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    11. (1 articles) Siavash Yousefi
    12. (1 articles) Yasushi Ikuno
    13. (1 articles) Aljoscha S. Neubauer
    14. (1 articles) Giovanni Staurenghi
    15. (1 articles) Robert N. Weinreb
  4. OCT Companies in the News

    1. (2 articles) Carl Zeiss Meditec
    2. (1 articles) Heidelberg Engineering
    3. (1 articles) Optos
    4. (1 articles) Avinger
    5. (1 articles) Optores
  5. Picture Gallery

    3D in vivo imaging with extended-focus optical coherence microscopy Post-doctoral Research Fellowship at FDA – Microglial imaging Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart Lower Extremity Revascularization Using Optical Coherence Tomography–Guided Directional Atherectomy: Final Results of the EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for Use in the Peripheral Vasculature (VISION) St Society for the Blind and Visually Impaired to Present Prestigious Leslie Dana Gold Medal at Visionary Gala in St. Louis Avinger to lay off a third of workforce Perth Researchers Developed the World's Smallest Microscope You can’t judge a book by its cover: a trivial angiographic image, an optical coherence tomography run and a surprising ending Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada Mechanical Design Engineer Opening at Optovue OCT Technology: Will We Be “Swept” Away? Opportunity Research Assistant/Associate in Biophotonics and Endoscopic Imaging at Imperial College London
  6. Recent Quotes

    1. This honor highlights the commitment Avinger has to bring the most advanced technology to market for physicians dedicated to treating PAD and their patients who are affected by this disease...Pantheris radically changes the treatment of vascular disease and the Edison Award represents a win for our entire Lumivascular portfolio.
      By John B. Simpson
    2. While we have been actively advancing our lesion assessment technology for the last two years, we are very pleased to see that the significant Series B investment will give MedLumics the means to complete our best-in-class product, conduct a series of international clinical trials to prove its safety and efficacy, and market it to specialist centers. As the company advances and grows into new areas, we will now expand and develop the team internationally.
      By Eduardo Margallo Balbás
    3. It's the most rapidly adopted ophthalmic technology in history.
      By Joel S. Schuman
    4. Our OCT Angiography congresses is a major force in promoting the transition from FA to OCTA by educating the ophthalmologists .
      By Bruno Lumbroso
    5. The development of OCT in the early 1990s greatly benefited from components and methods used in fiber-optical communications...And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    6. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    7. Our study demonstrates world-record results in cubic meter volume imaging, with at least an order of magnitude larger depth range and volume compared to previous demonstrations of three-dimensional OCT...These results provide a proof-of-principle demonstration for using OCT in this new regime...Long-range OCT is a new range of operation that requires extremely high performance light sources, integrated optical receivers and signal processing.
      By James G. Fujimoto
    8. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    9. "The development of OCT in the early 1990s greatly benefited from components and methods used in fiber optical communications,. And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    10. OCT has revolutionized the treatment of eye disease on a global basis and it is now routinely used to make clinical decisions in treating patients with blinding eye diseases...I’ve been honored to be part of the team that created this technology and to know our creation has improved diagnosis and treatment for millions of eye patients around the world.
      By Carmen A. Puliafito