1. Recent Articles From Around The Web

    1. Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital

      Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital

      Employer Description Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. Led by Guillermo ...

      Read Full Article
    2. Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss

      Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss

      Aims To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss. Methods Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF ...

      Read Full Article
    3. Miniaturizing medical imaging, sensing technology

      Miniaturizing medical imaging, sensing technology

      Scientists in Christine Hendon's and Michal Lipson's research groups at Columbia University, New York, have used a microchip to map the back of the eye for disease diagnosis. The interference technology, like bat sonar but using light instead of sound waves , used in the microchip has been around for a little while. This is the first time that technical obstacles have been overcome to fabricate a miniature device able to capture high quality images. Ophthalmologists' current optical coherence tomography (OCT) devices and surveyors' light detection and ranging (LIDAR) machines are bulky and expensive. There is a push for ...

      Read Full Article
    4. On-chip tunable photonic delay line

      On-chip tunable photonic delay line

      An on-chip tunable photonic delay line is a key building block for applications including sensing, imaging, and optical communication. However, achieving long and tunable delay lines within a small footprint remains challenging. Here, we demonstrate an on-chip tunable photonic delay line using ultralow loss high confinement Si 3 N 4 waveguides with integrated microheaters. As an example of potential application, we embed a 0.4 m delay line within an optical coherence tomography (OCT) system. We show that the delay line can extend the OCT imaging range by 0.6 mm while maintaining a high signal to noise ratio. Our ...

      Read Full Article
    5. Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance

      Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance

      Expanding the company's lineup of eye-care product offerings, Canon U.S.A. , Inc., a leader in digital imaging solutions, is pleased to announce the new intuitive, user-friendly Xephilio OCT-A1 Optical Coherence Tomography device from Canon Inc. This device features automated acquisition functionality, which makes it easy to use, allowing healthcare professionals to obtain high-quality reproducible scans and images. The Xephilio OCT-A1 Optical Coherence Tomography device has received FDA 510(k) clearance for sale in the United States of America 1. The Xephilio OCT-A1 Optical Coherence Tomography device, together with the required RX Capture software, computer and LCD monitor (collectively ...

      Read Full Article
    6. Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Objectives The aim of this study was to compare angiographic and optical coherence tomography findings following subintimal as opposed to intraplaque recanalization of chronic total occlusions (CTOs). Background There is ongoing controversy regarding outcomes of intraplaque versus subintimal CTO recanalization. Methods Consecutive patients undergoing angiography and intravascular optical coherence tomography following CTO recanalization were included in the ISAR-OCT-CTO (Intracoronary Stenting and Angiographic Results - Optical Coherence Tomography for Chronic Total Occlusions) registry. The study endpoints were percent diameter stenosis and late lumen loss as well as rate of uncovered and malapposed struts. Independent correlates of uncovered and malapposed struts were assessed ...

      Read Full Article
    7. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data, including current approaches used in modeling light scattering in tissue and in AC estimation. We also report on demonstrated clinical applications of the AC, such as for atherosclerotic tissue characterization ...

      Read Full Article
    8. Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Optical sensors are ubiquitous for their precision and non-contact acquisition, and have enjoyed widespread use in applications such as biosensing, environmental monitoring, and security. Despite their sensitivity, many of these sensors rely on costly laboratory instrumentation, and are not adaptable to the ever-growing volume of consumer detectors and optics that are readily available, making their application limited to benchtop analytics. This work leverages plasmonic resonances and optical coherence phenomena to make modifications upon traditional sensing formats that improve their sensitivity when deployed in off-the-shelf optical systems. In particular, we demonstrate that label-free plasmonic sensors can be combined with electrochemical impedance ...

      Read Full Article
    9. Recent progress in optical probing and manipulation of tissue: introduction

      Recent progress in optical probing and manipulation of tissue: introduction

      This feature issue of Biomedical Optics Express represents a cross-section of the most recent work in tissue optics, including exciting developments in tissue optical clearing, deep tissue imaging, optical elastography, nanophotonics in tissue, and therapeutic applications of light, amongst others. A collection of 33 papers provides a comprehensive overview of current research in tissue optics, much of it inspired and informed by the pioneering work of Prof. Valery Tuchin. The issue contains three invited manuscripts and several mini-reviews that we hope will benefit researchers in this exciting area.

      Read Full Article
    10. Elimination of Artifacts Caused by the Nonidentity of Parallel Signal-Reception Channels in Spectral Domain Optical Coherence Tomography

      Elimination of Artifacts Caused by the Nonidentity of Parallel Signal-Reception Channels in Spectral Domain Optical Coherence Tomography

      We study the causes of artifact appearance in the images obtained by the method of spectral domain optical coherence tomography with parallel reception of the optical-spectrum components, which are manifested in repetition and overlay of the structural elements of the images of the studied medium with a shift in depth. It is shown that nonidentity of the transfer characteristics of the channels of the multichannel photoreceiving elements is one of the sources of such artifacts. A numerical method for eliminating such artifacts is proposed and experimentally verified. This method is based on using the models whose parameters are estimated by ...

      Read Full Article
    11. Changes in Amblyopia Using Optical Coherence Tomography

      Changes in Amblyopia Using Optical Coherence Tomography

      There have been multiple trials to investigate the morphological changes in the macula and retinal nerve fiber layer of amblyopic eyes, due to the different published results and the lack of evident association between these changes and the patients' parameters. So, we perform this study to compare the variations in macular parameters (central thickness, average thickness, macular volume) and peripapillary thickness in different cases of amblyopic eyes versus the normal fellow eyes using spectral-domain optical coherence tomography . In addition, to estimate the relationship of optical coherence tomography variations with different defined patients' parameters (age, sex, best corrected visual acuity, spherical ...

      Read Full Article
    12. Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

      Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

      Purpose To determine the long‐term repeatability of optical coherence tomography angiography (OCTA) parameters in normal eyes. Methods We prospectively enrolled 104 normal eyes. Participants were divided into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. We measured a foveal centred scan area of 3 × 3 mm pattern. All measurements were performed twice at 5‐min intervals at the initial visit. The second measurements were performed at least 6 months later. Results In short‐term ...

      Read Full Article
    13. Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease

      Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease

      Purpose : This study assessed agreement between an automated spectral-domain optical coherence tomography (SD-OCT) retinal segmentation software and manually corrected segmentation to validate its use in a prospective clinical study of neurodegenerative diseases (NDD). Methods : The sample comprised 30 subjects with NDD, including vascular cognitive impairment, frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. Macular SD-OCT scans were acquired and segmented using Heidelberg Spectralis. For the central foveal B scan of each eye, eight segmentation lines were examined to determine the proportion of each line that the software erroneously delineated. Errors in four lines were manually corrected in all B ...

      Read Full Article
    14. Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration

      Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration

      Age-related macular degeneration (AMD) is a vision-threatening disease that affects the outer retina and choroid of elderly adults. Because photoreceptors are found in the outer retina and rely primarily on the trophic support of the underlying choriocapillaris, imaging of flow or lack thereof in choriocapillaris by optical coherence tomography angiography (OCTA) has great clinical potential in AMD assessment. We introduce a metric using OCTA, named “focal perfusion loss” (FPL) to describe the effects of age and non-neovascular AMD on choriocapillaris flow. Because OCTA imaging of choriocapillaris is vulnerable to artifacts—namely motion, projections, segmentation errors, and shadows—they are removed ...

      Read Full Article
    15. Disproportion of lamellar capillary non-perfusion in proliferative diabetic retinopathy on optical coherence tomography angiography

      Disproportion of lamellar capillary non-perfusion in proliferative diabetic retinopathy on optical coherence tomography angiography

      Purpose To characterise the non-perfused areas (NPAs) in the superficial and deep capillary layers (sNPAs and dNPAs, respectively) in the posterior pole in proliferative diabetic retinopathy (PDR) on wide-field optical coherence tomography angiography (OCTA) images. Methods We retrospectively reviewed 104 eyes of 70 patients with PDR from whom wide-field swept source OCTA images were acquired. sNPAs and dNPAs were manually measured in each quadrant of the inner (1–3 mm diameter), intermediate (3–6 mm), and outer (6–10 mm) rings centred on the fovea. Two qualitative findings, that is, segmented NPAs and periarteriolar NPAs , were also compared. Results The ...

      Read Full Article
    16. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (2 articles) Center for Ophthalmic Optics and Lasers
    2. (2 articles) Institute of Applied Physics
    3. (2 articles) Harvard University
    4. (2 articles) Massachusetts General Hospital
    5. (2 articles) Oregon Health & Science University
    6. (2 articles) Columbia University
    7. (2 articles) University of Western Australia
    8. (1 articles) Johns Hopkins University
    9. (1 articles) University of Southern California
    10. (1 articles) University College London
  3. People in the News

    1. (2 articles) Guillermo J. Tearney
    2. (2 articles) Grigory V. Gelikonov
    3. (2 articles) David Huang
    4. (2 articles) Christine P. Hendon
    5. (2 articles) Steven T. Bailey
    6. (2 articles) Pavel A. Shilyagin
    7. (2 articles) Valentin M. Gelikonov
    8. (2 articles) Yali Jia
    9. (1 articles) Ravi S. Jonnal
    10. (1 articles) Robert J. Zawadzki
    11. (1 articles) Brian E. Applegate
    12. (1 articles) Fred K. Chen
    13. (1 articles) John S. Oghalai
    14. (1 articles) David Alonso-Caneiro
    15. (1 articles) Mehdi Azimipour
  4. OCT Companies in the News

    1. (2 articles) Canon Medical Systems
    2. (1 articles) Optovue
    3. (1 articles) Topcon Medical Systems
    4. (1 articles) Wasatch Photonics
    5. (1 articles) Carl Zeiss Meditec
    6. (1 articles) Specsavers
  5. Picture Gallery

    Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial Integrated optical system with photonic integrated circuit including coherent optical receiver and optical phased array Optoretinography: optical measurements of human cone and rod photoreceptor responses to light OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT Electromagnetic analysis for optical coherence tomography based through silicon vias metrology Postdoc Position at the University of Southern California Specsavers Installs the 350th Topcon Maestro Fully Automated OCT Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University ZEISS Showcases New CIRRUS 6000 OCT System at the European Society of Retina Specialists 2019 Congress PhD Position at the Center for Medical Physics and Biomedical Engineering – Medical University of Vienna
  6. Recent Quotes

    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    2. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    3. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    4. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    5. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    6. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    7. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    8. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    9. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    10. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden