1. Feature Of The Week

    Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Using shear wave elastography, the shear modulus of a soft tissue can be quantified by tracking the shear wave propagation. In previous measurements, the transverse shear wave propagates perpendicular to the force direction, so the shear modulus in the lateral region of the force can be quantified. However, the shear modulus in the axial region of the force cannot be measured.

    Dr. Jiang Zhu, Yusi Miao and other researchers in Prof. Zhongping Chen’s group at the Beckman Laser Institute, the University of California Irvine, visualized a longitudinal shear wave using optical coherence tomography for the quantitative mapping of shear moduli. They demonstrated that a longitudinal shear wave propagated along the vibration direction as a plane wave in the near field of a planar source, and the shear modulus in the axial region of the force was quantified. Furthermore, combination of the transverse shear wave and the longitudinal shear wave provides opportunities for measuring directionally dependent elastic properties in tissues, such as muscles, tendons, etc.

    The utilization of the longitudinal shear wave provides good theoretical and practical insights. This is an important improvement to resolve the limited field of view in optical coherence elastography, and provides significant information for the clinical diagnosis of diseases.

    For more information see recent Article. Courtesy Jiang Zhu, from University of California at Irvine. To share this article click Here.

  2. Featured Articles

    1. Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography

      Explore aip.scitation.org
      Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography

      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Previous transverse shear wave measurements could detect the shear modulus in the lateral region of the force; however, they could not provide the elastic information in the axial region of the force. In this study, we report the imaging and quantification of longitudinal shear wave propagation using optical coherence tomography to measure the elastic properties along the force direction. The experimental validation and ...

      Read Full Article
      Mentions: Zhongping Chen UC Irvine Jiang Zhu

    2. Faculty Position at Geisinger Medical Center

      Explore Optical Coherence Tomography News Jobs & Studentships
      Faculty Position at Geisinger Medical Center

      JOB SUMMARY: The Department of Imaging Science and Innovation within the Biomedical and Translational Informatics Institute at Geisinger Medical Center in Danville, PA is seeking to hire faculty members at all levels (Assistant, Associate and Professor). The ideal candidate will have a background in engineering, computer science, mathematics, radiology, or related field. In particular, emphasis will be placed on applicants with a record of research accomplishments in translational imaging and image processing, machine learning, and the intersection between radiology and genomics. A successful candidate will have high potential to establish a strong individual research program within a highly collaborative environment ...

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    3. Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT

      Explore OSA | OSA Publishing Ophthalmology
      Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT

      Conventional imaging of the human cornea with optical coherence tomography (OCT) relies on telecentric scanning optics with sampling beams that are parallel to the optical axis of the eye. Because of the shape of the cornea, the beams have in some areas considerable inclination to the corneal surface which is accompanied by low signal intensities in these areas and thus an inhomogeneous appearance of corneal structures. In addition, alterations in the polarization state of the probing light depend on the angle between the imaging beam and the birefringent axis of the sample. Therefore, changes in the polarization state observed with ...

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      Mentions: Christoph K. Hitzenberger Michael Pircher Medical University of Vienna

    4. PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      Explore Optical Coherence Tomography News Gastroenterology , Jobs & Studentships
      PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a PhD position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in October 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government by ...

      Read Full Article
      Mentions: FEMTO-ST Institute

    5. New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis

      Explore tyndall.ie Gastroenterology
      New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis

      Researchers at Tyndall National Institute at UCC are taking part in a new European project to develop a low cost, easy to use 3D imaging system that will help enable faster and more accurate diagnosis of colorectal cancers. The Optical Coherence Tomography (OCT) system is being developed by Tyndall as part of the recently launched PICCOLO project, an EU Horizon 2020 funded initiative, bringing together scientists and clinicians across Europe to create an endoscope probe to better diagnose bowel polyps and early colon cancer. Tyndall researcher, Dr. Brendan Roycroft explains: “ Using breakthrough photonics, (the generation, manipulation and utilisation of light ...

      Read Full Article
      Mentions: University College Cork

    6. NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented

      Explore NinePoint Medical Gastroenterology , Other Business News
      NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented

      – NinePoint Medical, Inc., a transformative medical device company pioneering the use of advanced Optical Coherence Tomography (OCT) for gastrointestinal applications, will be featuring the NvisionVLE® Imaging System with Real-time Targeting™ at Digestive Disease Week® (DDW) 2017, which will be held May 6-9 in Chicago. In addition, results from various studies utilizing this technology in gastroenterology will be presented in 24 scientific abstracts throughout the conference. Random biopsy is the current standard of care for diagnosing esophageal diseases such as Barrett’s esophagus, squamous cell carcinoma, and adenocarcinoma. However, random biopsies assess less than 3% of the esophageal surface1 , leaving more ...

      Read Full Article
      Mentions: UC Irvine NinePoint Medical Patrick MacCarthy

    7. Damae Medical Raises €2M in Funding

      Explore Optical Coherence Tomography News Dermatology , Funding , Other Business News
      Damae Medical Raises €2M in Funding

      Damae Medical , a Paris, France-based medtech company, closed a €2m funding. Backers included Kurma Partners, Idinvest Partners, News Invest, Paris-Saclay Seed Fund co-managed by Partech Ventures, and private investors. The company intends to use the funds to finance the development and CE marking of OCTAV®, which is scheduled for mid-2018. Founded in September 2014 by Anaïs Barut, CEO, Damae Medical aims to provide dermatologists with a novel, in vivo imaging technology for a deep look into the skin. This technology enables cellular-resolution imaging of the skin similar to histology, without the need for tissue excision and processing. The company ...

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      Mentions: Arnaud Dubois Damae Medical

    8. Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI

      Explore BMC Cardiovascular Disorders Cardiology
      Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI

      Background Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective in atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence of EPC on coronary plaque burden in stable disease and implemented a novel computational plaque analysis algorithm using OCT. Methods Forty-three patients (69.8% males, 69.6 ± 7.7 years) were investigated by OCT during re-angiography 6 months after elective stent implantation. Different subpopulations of EPCs were identified by flow cytometry according to their co-expression of antigens (CD34+, CD133+, kinase domain ...

      Read Full Article
      Mentions: Juan Luis Gutiérrez-Chico Sylvia Otto

    9. Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection

      Explore Nature Publishing Group Neurology
      Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection

      Cancer is known to alter the local optical properties of tissues. The detection of OCT-based optical attenuation provides a quantitative method to efficiently differentiate cancer from non-cancer tissues. In particular, the intraoperative use of quantitative OCT is able to provide a direct visual guidance in real time for accurate identification of cancer tissues, especially these without any obvious structural layers, such as brain cancer. However, current methods are suboptimal in providing high-speed and accurate OCT attenuation mapping for intraoperative brain cancer detection. In this paper, we report a novel frequency-domain (FD) algorithm to enable robust and fast characterization of optical ...

      Read Full Article
      Mentions: Johns Hopkins University Xingde Li

    10. Finalists for the European Inventor Award 2017

      Explore EPO - Home
      Finalists for the European Inventor Award 2017

      The European Patent Office (EPO) today announced that the team of U.S. Engineers James G. Fujimoto and Eric A. Swanson, and German Physicist Robert Huber, have been named finalists for the European Inventor Award 2017 in the category of “Non-European countries" for medical imaging with optical coherence tomography (OCT). The winners of the 12th edition of the EPO’s annual innovation prize will be announced at a ceremony held on June 15th at the Arsenale di Venezia in Venice, Italy.

      Read Full Article
      Mentions: Massachusetts Institute of Technology James G. Fujimoto Robert A. Huber
    11. See all articles

  3. Recent Articles From Around The Web

    1. Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Explore Optical Coherence Tomography News
      Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Using shear wave elastography, the shear modulus of a soft tissue can be quantified by tracking the shear wave propagation. In previous measurements, the transverse shear wave propagates perpendicular to the force direction, so the shear modulus in the lateral region of the force can be quantified. However, the shear modulus in the axial region of the force cannot be measured. Dr. Jiang ...

      Read Full Article
      Mentions: Zhongping Chen UC Irvine Jiang Zhu

    2. Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Explore eurointervention.org Cardiology
      Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

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      Mentions: Academic Medical Center at the University of Amsterdam Walter Desmet K. U. Leuven

    3. Wide Broadband ASE Source based on Thulium-doped Fibre for 2 μm Wavelength Region

      Explore ResearchGate Broadband Sources
      Wide Broadband ASE Source based on Thulium-doped Fibre for 2 μm Wavelength Region

      This paper investigates the generation of the amplified spontaneous emission (ASE) from thulium-doped silica fibre pumped at 1570 nm. The developed model provides the ASE spectral power at short and long wavelength bands by using two different thulium doped fibre types with optimized fibre length. Shorter wavelengths in the emission band can be accessed with a short thulium fibre, whereas longer wavelengths can be obtained using a long thulium fibre. Our findings reveal that, in contrast to a 100 nm (1800nm- 1900nm) and 70 nm (1900nm-1970nm) broadband source at short and long wavelength bands, a broader spectrum source can be ...

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    4. Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Explore ScienceDirect Ophthalmology
      Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Purpose To describe the retinochoroidal vascular alterations in patients with human immunodeficiency virus (HIV) infection using en face OCT angiography (OCTA). Design Cross-sectional study. Participants Twenty-six patients with HIV infection (5 women, with and without HIV retinopathy) were included in the study. Nineteen healthy participants (7 women) with no known ocular disease were recruited as healthy controls. Methods Multimodal imaging was performed using OCTA (Optovue RTVue XR Avanti; Optovue, Inc, Fremont, CA), enhanced-depth imaging OCT (Heidelberg Spectralis; Heidelberg Engineering, Heidelberg, Germany), color fundus photography, and fluorescein angiography (FA). Vessel flow density (VFD) was calculated automatically by the OCTA software. Morphologic ...

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      Mentions: Optovue Heidelberg Engineering Optovue RTVue-100

    5. Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy

      Explore European Urology Focus Urology
      Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy

      Context With more complex kidney tumors treated by nephron-sparing surgery (NSS), complete tumor resection is becoming increasingly challenging. Intraoperative imaging may improve the establishment of negative surgical margins. Objective To discuss intraoperative imaging techniques that may help achieve complete tumor resection in NSS of renal tumors. Evidence acquisition PubMed was searched for English articles on intraoperative imaging during NSS of renal cell carcinoma published after 2005, and a reference search of retrieved articles was performed. Evidence synthesis Included studies reported about ultrasonography, fluorescence imaging, augmented reality, optical coherence tomography, and ex vivo magnetic resonance imaging (MRI). The number of patients ...

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    6. AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS

      Explore ResearchGate
      AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS

      In this paper, we present a real-time instantaneous phase estimation technique for the calibration of swept source optical coherence tomography (SS-OCT) systems. The proposed algorithm is able to accurately estimate both the amplitude and phase content of a swept source signal. The results are robust in the presence of substantial noise. Furthermore, the resulting phase profile is readily unwrapped, allowing for the generation of a k-linear sampling clock by means of a simple comparison step, which enables the SS-OCT system operator to determine the required number of points for accurate image reconstruction without the need for MZI path length modification ...

      Read Full Article
      Mentions: Texas A&M University

    7. Foveal Curvature and Asymmetry Assessed Using Optical Coherence Tomography

      Explore LWW Online Ophthalmology
      Foveal Curvature and Asymmetry Assessed Using Optical Coherence Tomography

      Purpose: The aims of this study were to use cross-sectional optical coherence tomography imaging and custom curve fitting software to evaluate and model the foveal curvature as a spherical surface and to compare the radius of curvature in the horizontal and vertical meridians and test the sensitivity of this technique to anticipated meridional differences. Methods: Six 30-degree foveal-centered radial optical coherence tomography cross-section scans were acquired in the right eye of 20 clinically normal subjects. Cross sections were manually segmented, and custom curve fitting software was used to determine foveal pit radius of curvature using the central 500, 1000, and ...

      Read Full Article

    8. Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      Explore Ophthalmology Ophthalmology
      Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      A 24-year-old woman with type I diabetes mellitus with significant macular ischemia in her left eye with a large net of neovascularization of the disc (Fig 1A). There is profound retinal capillary nonperfusion contrasting with perfusion of the neovascularization of the disc demonstrated on a full thickness 6×6-mm optical coherence tomography−angiography scan (Fig 1B), using Angiovue software (Optovue, Inc. Fremont, CA).

      Read Full Article
      Mentions: Optovue

    9. Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      Explore Ophthalmology Ophthalmology
      Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      To the Editor: We read with interest the study by Goto et al, 1 who described a new formula to predict the postoperative position of the intraocular lens (IOL). Although their results are interesting and might be useful for IOL power calculation, we feel that some comments are necessary. First, comparing what they define as the “postoperative external anterior chamber depth,” either measured or predicted by anterior segment optical coherence tomography, to the IOL position, as predicted by thin lens formulas, is not the proper method. The measurements performed by the authors, in fact, refer to a thick lens system ...

      Read Full Article
      Mentions: Giacomo Savini

    10. RE: Traber et al.: Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss (Ophthalmology. 2017;124:66-73)

      Explore Ophthalmology Ophthalmology
      RE: Traber et al.: Enhanced depth imaging optical coherence tomography of optic nerve head drusen: a comparison of cases with and without visual field loss (Ophthalmology. 2017;124:66-73)

      To the Editor: We read with interest the study by Traber et al, where the presence or absence of visual field defects was correlated with optic nerve head drusen (ONHD) morphology. 1 The ONHD were classified using enhanced depth imaging optical coherence tomography (OCT) morphologic characteristics as either peripapillary, granular, or confluent. The hyperreflective structures classified as peripapillary ONHD in the present study have previously been labeled as ONHD 2 ; however, we do not find substantial evidence for this suggestion. First, we regularly see similar hyperreflective mass-like peripapillary changes in OCT volume scans of patients with papilledema from idiopathic intracranial ...

      Read Full Article

    11. HS-UK to host Ophthalmic Ultrasound & OCT-A Course

      Explore prweb.com Ophthalmology
      HS-UK to host Ophthalmic Ultrasound & OCT-A Course

      Haag-Streit UK (HS-UK), the leading manufacturer and distributor of gold-standard optometry and ophthalmic equipment, is delighted to confirm that it will be hosting an Ophthalmic Ultrasound & OCT Course at Crewe Hall, Cheshire on Wednesday 28th June, 2017. The course is aimed at those working with ophthalmic ultrasound in their daily practice, and will cover both A-scans and B-scans, including how to capture them. Lectures will describe some of the common conditions observed using ultrasound, such as; retinal detachments & tears, vitreous haemorrhages & detachments and optic disc drusen & other dot lesions. The day will also include a lecture covering the detection of ...

      Read Full Article
      Mentions: Haag-Streit

    12. Measurement of macular structure-function relationships using spectral domain-optical coherence ...

      Explore Journals | PLOS Ophthalmology
      Measurement of macular structure-function relationships using spectral domain-optical coherence ...

      Background Retinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the central retinal function that correlates with macular GCL thickness. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERG amp ) and macular ganglion cell/inner plexiform layer thickness (GCIPLT). Methods and findings This was a retrospective and comparative study including 74 glaucoma patients (44 early stage and 30 advanced stage cases) and 66 normal control subjects. Macular GCIPLT was measured using Cirrus spectral domain-optical coherence tomography. Standard ...

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      Mentions: Nidek Carl Zeiss Meditec Pusan National University

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      Spontaneous Coronary Artery Dissection: Insights From Histology and Optical Coherence Tomography

      Spontaneous coronary artery dissection (SCAD) is a well-known but infrequent cause of acute coronary syndrome (ACS), and often goes unrecognized. Although management of SCAD is, at times, controversial, when a patient presents with ACS, percutaneous coronary intervention (PCI) is frequently necessary. We present a patient with ST-segment elevation myocardial infarction (STEMI) with SCAD that illustrates two important points: use of intracoronary optical coherence tomography to guide PCI, and histologic assessment to provide a unique insight into the etiology of SCAD. Following the case, we briefly review the important aspects of the pathophysiology, epidemiology, diagnosis, and interventional management of SCAD.

      Read Full Article
      Mentions: University of Washington

    14. Development and translation of label-free functional microscopy based on optical coherence tomography (Thesis)

      Explore DSpace@MIT Dermatology , Student Theses
      Development and translation of label-free functional microscopy based on optical coherence tomography (Thesis)

      Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization sensitive (PS) OCT techniques for clinical and preclinical applications. This goal includes four specific aims. The first aim is to develop a clinical imaging system to image the anatomy and microvasculature of human skin. The second aim is to develop a high performance post-processing algorithm for angiographic OCT. Towards this aim, we developed a processing algorithm based on complex differential variance (CDV) and confirmed its performance by ...

      Read Full Article
      Mentions: Massachusetts Institute of Technology

    15. THREE-DIMENSIONAL ANALYSIS OF SUBMACULAR PERFORATING SCLERAL VESSELS BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      Explore LWW Online Ophthalmology
      THREE-DIMENSIONAL ANALYSIS OF SUBMACULAR PERFORATING SCLERAL VESSELS BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To analyze submacular perforating scleral vessels (PSVs) using enhanced depth imaging spectral domain optical coherence tomography (EDI-SDOCT). Methods: Twenty-two eyes of 11 healthy women were included in this retrospective study. Central EDI-SDOCT scans (3 x 4.5 x 1.9 mm, 13.5 mm2 scan area) were acquired and postprocessed by denoising, manual sclera segmentation, and PSV investigated by five graders. Results: Mean age was 22.4 +/- 6.2 years. Mean refractive error was -0.44 +/- 0.8 diopters. Mean axial length was 23.08 +/- 0.63 mm. The coefficient of agreement for grading was good. Mean number of ...

      Read Full Article
      Mentions: Johns Hopkins University University Hospital Zurich Hendrik P. N. Scholl
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    Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography Faculty Position at Geisinger Medical Center Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented Damae Medical Raises €2M in Funding Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection Finalists for the European Inventor Award 2017 Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

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