1. Featured Articles

    1. BiOS Hot Topics: Changing of the Guard

      Explore Home: SPIE.org
      BiOS Hot Topics: Changing of the Guard

      The near-capacity crowd at their ultimate session this week broke into applause as Rox Anderson opened with "This is the largest meeting in the world for biomedical optics, and that's because of you!" He added that the reason BiOS has grown so popular is the diversity of the intellect and specialties that are featured in the symposium, such as those involved in medicine, bioscience, and physics. James Fujimoto introduced the new BiOS co-chairs, Jennifer Barton of the University of Arizona and Wolfgang Drexler of the University of Vienna. Touching on the impressive backgrounds of each, Fujimoto noted, "we know ...

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      Mentions: James G. Fujimoto Wolfgang Drexler Leiden University

    2. Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      Explore OSA | OSA Publishing
      Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      We propose a simplification for a robust and easy to implement fast phase unwrapping (FPU) algorithm that is used to solve the phase wrapping problem encountered in various fields of optical imaging and metrology. We show that the number of necessary computations using the algorithm can be reduced compared to its original version. FPU can be easily extended from two to three spatial dimensions. We demonstrate the applicability of the two- and three-dimensional FPU algorithm for Doppler optical coherence tomography (DOCT) in numerical simulations, and in the imaging of a flow phantom and blood flow in the human retina in ...

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      Mentions: Nicolaus Copernicus University Maciej Szkulmowski Iwona Gorczynska

    3. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Explore Nature Publishing Group Neurology , Oncology
      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

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      Mentions: Institute of Applied Physics Grigory V. Gelikonov Elena V. Zagaynova

    4. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Explore OSA | OSA Publishing Gastroenterology
      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    5. System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      Explore Optical Coherence Tomography News Jobs & Studentships
      System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      We are looking for In order to support our development department in Lübeck, we are looking for a professionally and personally convincing personality. We offer you an exciting and responsible position in a fast-growing company. Our Lübeck site specialises in OCT technology and systems integration. With your high understanding of systems, you will accompany a project from the initial conception, through the definition of the architecture, the construction of prototypes to testing and handover to production. Your responsibilities System development from the basic concept to production Evaluation of new technological possibilities Definition and elaboration of the system architecture ...

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      Mentions: Heidelberg Engineering

    6. Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA

      A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow or instructor at Harvard Medical School, commensurate with the applicant’s experience. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research. The fellowship will focus on high resolution OCT imaging ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    7. Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo

      Explore OSA | OSA Publishing
      Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo

      We demonstrate a synthetic subaperture-based angle-independent Doppler flow calculation, using a line field spectral domain optical coherence tomography system. The high speed of the system features a high phase stability over the volume, which is necessary to apply synthetic subapertures in the aperture plane. Thus, the flow component for each subaperture can be reconstructed in postprocessing. Capillary phantom and in vivo retinal imaging experiments were performed to validate and demonstrate angle-independent Doppler flow calculation

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      Mentions: Rainer A. Leitgeb Medical University of Vienna Lara M. Wurster

    8. SPECTRALIS OCT2 Module Improves Speed and Efficiency on the International Space Station

      Explore Optical Coherence Tomography News Ophthalmology
      SPECTRALIS OCT2 Module Improves Speed and Efficiency on the International Space Station

      Research on the effects of microgravity on vision continues with the SPECTRALIS multi-modal imaging platform. Heidelberg Engineering, a privately-held imaging and healthcare IT technologies company focused on ophthalmic diagnostic solutions that empower clinicians to improve patient care, announced that its SPECTRALIS imaging platform with the company’s next-generation OCT2 Module has been successfully installed at the International Space Station (ISS) and is now fully operational. NASA launched the SPECTRALIS with OCT2 Module to the ISS aboard the Antares 230 Cygnus CRS OA-9, also known as Orbital Sciences CRS Flight 9E, from Wallops Island, Virginia, last May. The new imaging platform ...

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      Mentions: Heidelberg Engineering Heidelberg Spectralis

    9. Toward a multimodal fusion of layered cultural object images: complementarity of optical coherence tomography and terahertz time-domain imaging in the heritage field

      Explore OSA | OSA Publishing Art
      Toward a multimodal fusion of layered cultural object images: complementarity of optical coherence tomography and terahertz time-domain imaging in the heritage field

      Terahertz time-domain imaging (THz-TDI) and spectral-domain optical coherence tomography (SD-OCT) are two techniques capable of providing 3D datasets from which depth profiles and cross-sectional images of an object can be derived. They are novel photonics technologies of particular relevance to the field of heritage science, for which the comprehension of the stratigraphic structure of a cultural heritage object may help in the understanding of its artistic technology and state of preservation. The differences in imaging depth, field of view, and axial/lateral resolutions of the two imaging techniques provide different but complementary information of the same scene. Through the use ...

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  2. Recent Articles From Around The Web

    1. Optical coherence tomography imaging in keratoconus

      Explore Wiley Online Library Ophthalmology
      Optical coherence tomography imaging in keratoconus

      Invited Review: Optical coherence tomography (OCT) is being increasingly used as a tool in the diagnosis and management of keratoconus. While elevation‐based topography remains essential, there is an expanding role for cross‐sectional OCT imaging in the diagnosis of the disease. Images and measurements of corneal thickness, and in particular, epithelial thickness, may be important in diagnosing early cases, and following procedures such as intrastromal corneal ring segments, corneal transplants and corneal collagen cross‐linking.

      Read Full Article

    4. Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Explore Sistema Eletrônico de Revistas Dentistry
      Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Objective: To evaluate the use of nanosilver fluoride in the enamel remineralization process through optical coherence tomography . Material and Methods: All samples were submitted to demineralization process by pH cycling during 14 days and randomly distributed into three groups (n = 11): Nanosilver Fluoride (NSF), Sodium fluoride (NaF), and negative control. Optical coherence tomography images were acquired at three different moments: initial stage (T0), post caries formation (T1), and post pH cycling (T2). The integrity of the enamel surface and the measurement of the volume loss for the tissue after pH cycling in comparison to initial images were obtained from optical ...

      Read Full Article
      Mentions: Anderson S. L. Gomes Federal University of Pernambuco Cláudia Cristina Brainer Oliveira Mota

    5. Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      Explore Healio.com Ophthalmology
      Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      BACKGROUND AND OBJECTIVE: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH). PATIENTS AND METHODS: A case series of eight patients diagnosed with IRAH. RESULTS: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions. Fundus autofluorescence (FAF) changes were seen in all eight cases. Ocular ultrasound was able to identify a lesion in only five of the seven cases. Optical coherence tomography ...

      Read Full Article

    6. Choroidal Vascularity Index Using Swept-Source and Spectral-Domain Optical Coherence Tomography: A Comparative Study

      Explore Healio.com Ophthalmology
      Choroidal Vascularity Index Using Swept-Source and Spectral-Domain Optical Coherence Tomography: A Comparative Study

      BACKGROUND AND OBJECTIVE: Choroidal vascularity index (CVI) is a noninvasive tool to assess choroidal structure. The objective of the current study was to compare the CVI measurements on swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) scans using the same image binarization protocol. PATIENTS AND METHODS: This prospective study was conducted from July 2016 through January 2017 and involved 54 healthy volunteers at a tertiary referral eye care institute in Southern India. Choroidal scans were obtained using both SS- and SD-OCT machines. An automated binarization algorithm was used to compute CVI. RESULTS: The mean CVI with SS-OCT scans was ...

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    7. Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD‐OCT)

      Explore Wiley Online Library Ophthalmology
      Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD‐OCT)

      Purpose The purpose of this case series is to evaluate the use of spectral domain optical coherence tomography (SD‐OCT) imaging in equine corneal disease to demonstrate the feasibility, diagnostic effectiveness, and limitations of this imaging modality. Methods Retrospective study: Handheld SD‐OCT (Envisu, Bioptigen Inc, Morrisville, NC) was used for high‐resolution imaging of horses with corneal disease presenting to the North Carolina State University Equine Ophthalmology Service from 2013 to 2018. Results Fourteen horses were included in this study, including six horses with corneal ulceration, three with stromal abscesses (SA), three with immune‐mediated keratitis (IMMK), and two ...

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      Mentions: Bioptigen

    8. Attention to Lesion: Lesion-Aware Convolutional Neural Network for Retinal Optical Coherence Tomography Image Classification

      Explore IEEE Xplore Ophthalmology
      Attention to Lesion: Lesion-Aware Convolutional Neural Network for Retinal Optical Coherence Tomography Image Classification

      Automatic and accurate classification of retinal optical coherence tomography (OCT) images is essential to assist ophthalmologist in the diagnosis and grading of macular diseases. Clinically, ophthalmologists usually diagnose macular diseases according to the structures of macular lesions, whose morphologies, size, and numbers are important criteria. In this paper, we propose a novel lesion-aware convolutional neural network (LACNN) method for retinal OCT image classification, in which retinal lesions within OCT images are utilized to guide the CNN to achieve more accurate classification. The LACNN simulates the ophthalmologists’ diagnosis that focuses on local lesion-related regions when analyzing the OCT image. Specifically, we ...

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    9. Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment

      Explore Wiley Online Library Cardiology
      Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment

      Objective To use optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in assessing myocardial bridging (MB) vessel size and wall thickness. Background During stent implantation, MB is associated with complications, especially perforation. Methods OCT and IVUS were performed in 56 patients with typical angiographic “milking” from November 2016 to May 2017. The vessel area and thickness in the MB segments and adjacent proximal and distal reference segments were measured and compared with eight normal left anterior descending (LAD) segment (no atherosclerosis in a segment that was at least 20 mm long and that began ~40 mm distal to the LAD ...

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      Mentions: Cardiovascular Research Foundation Gary S. Mintz

    10. Telecentric broadband objective lenses for optical coherence tomography

      Explore OSA | OSA Publishing Ophthalmology
      Telecentric broadband objective lenses for optical coherence tomography

      Freeform optical components enable significant advances for optical systems. A major challenge for freeform optics is the current lack of metrology methods with measurement uncertainty on the order of tens of nanometers or less. Towards addressing this challenge, optical coherence tomography (OCT) is a viable technique. In the context of low uncertainty metrology, the design requirements pertaining to the sample arm of an OCT metrology system are explicitly addressed in this paper. Two telecentric, broadband, diffraction limited, custom objective lens designs are presented with their design strategies. One objective lens was fabricated and experimentally tested for wavefront performance and telecentricity ...

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      Mentions: University of Rochester Jannick P. Rolland

    12. (Cost)-Effectiveness of OCT in BCC (ROCTI)

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      (Cost)-Effectiveness of OCT in BCC (ROCTI)

      Skin cancer incidence rises worldwide due to high sun exposure and ageing. Basal cell carcinoma (BCC) is the most prevalent form, with a lifetime risk of 16-20% in the Netherlands. Currently, the gold standard for diagnosing and subtyping basal cell carcinoma (BCC) is a punch biopsy. Since this technique is invasive, new non-invasive diagnostic methods have been developed, including optical coherence tomography (OCT). In patients with clinical and dermoscopic suspicion of BCC, OCT makes it possible to confirm and subtype BCC with high confidence, thereby obviating the need for a punch biopsy in a substantial part of patients. Hence, BCC ...

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      Mentions: Academic Hospital Maastricht

    13. Precision analysis and optimization in phase decorrelation OCT velocimetry

      Explore OSA | OSA Publishing
      Precision analysis and optimization in phase decorrelation OCT velocimetry

      Quantitative flow velocimetry in Optical Coherence Tomography is used to determine both the axial and lateral flow component at the level of individual voxels. The lateral flow is determined by analyzing the statistical properties of reflected electro-magnetic fields for repeated measurements at (nearly) the same location. The precision or statistical fluctuation of the quantitative velocity estimation depends on the number of repeated measurements and the method to determine quantitative flow velocity. In this paper, both a method to determine quantitative flow velocity and a model for the prediction of the statistical fluctuations of velocity estimations are developed to analyze and ...

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      Mentions: Johannes F. de Boer VU University Amsterdam

    14. Image-guided vibrometry system integrated with spectral- and time-domain optical coherence tomography

      Explore OSA | OSA Publishing
      Image-guided vibrometry system integrated with spectral- and time-domain optical coherence tomography

      Vibrometry using optical coherence tomography (OCT) can provide valuable information for investigating either the mechanical properties or the physiological function of biological tissues, especially the hearing organs. Real-time imaging of the measured tissues provides structure imaging and spatial guidance for and is thus highly demanded by such vibrometry. However, the traditional time-domain OCT (TD-OCT) systems, although capable of subnanometric vibrometry at large ranges of frequencies, are unable to offer an imaging speed that is high enough to acquire depth-resolved images for guidance. The spectral-domain OCT (SD-OCT) systems, although allowing image-guided vibrometry, are challenged in measuring vibration at high frequencies, particularly ...

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      Mentions: Tsinghua University Yonghong He Fangyi Chen

    15. Faster, wider, deeper: imaging advances in focus at Hot Topics session

      Explore Home: SPIE.org
      Faster, wider, deeper: imaging advances in focus at Hot Topics session

      Continuing the theme, Yoshiaki Yasuno from the University of Tsukuba in Japan followed Xu with a talk on extending optical coherence tomography (OCT) toward multiple-contrast imaging. Yasuno notes that although several such extensions, like Doppler OCT, OCT angiography, and polarization-sensitive OCT, have been investigated for several years, image interpretation is often complicated, so the clinical value of the techniques has only been recognized recently. The Tsukuba group studies various forms of OCT and their applications in ophthalmology and dermatology. Work being presented at Photonics West 2019 included compression-based, polarization-sensitive optical coherence elastography (PS-OCE), developed for simultaneous analysis of bire¬fringence ...

      Read Full Article
      Mentions: Cornell University Yoshiaki Yasuno University of Tsukuba
      16. See all articles
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  6. Organizations in the News

    1. (2 articles) UCLA
    2. (2 articles) National Institutes of Health
    3. (2 articles) University of Tsukuba
    4. (2 articles) Massachusetts General Hospital
    5. (2 articles) UC Davis
    6. (2 articles) Cornell University
    7. (2 articles) VU University Amsterdam
    8. (1 articles) Stanford University
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  7. People in the News

    1. (2 articles) Yoshiaki Yasuno
    2. (1 articles) Vivek J. Srinivasan
    3. (1 articles) Guillermo J. Tearney
    4. (1 articles) Anita Mahadevan-Jansen
    5. (1 articles) Michalina J. Góra
    6. (1 articles) John S. Werner
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    8. (1 articles) Rox Anderson
    9. (1 articles) Jon Holmes
    10. (1 articles) Anderson S. L. Gomes
    11. (1 articles) Giovanni Gregori
    12. (1 articles) Norman S. Nishioka
    13. (1 articles) Philip J. Rosenfeld
    14. (1 articles) Ravi S. Jonnal
    15. (1 articles) Chia-Pin Liang

  8. OCT Companies in the News

    1. (2 articles) Optovue
    2. (2 articles) Carl Zeiss Meditec
    3. (2 articles) Bioptigen
    4. (1 articles) Movu
    5. (1 articles) Tomey Corporation
    6. (1 articles) Santec
    7. (1 articles) MedLumics
    8. (1 articles) Nidek
    9. (1 articles) Heidelberg Engineering
    10. (1 articles) Michelson Diagnostics

  9. Picture Gallery

    BiOS Hot Topics: Changing of the Guard Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients System Engineer Opening at Heidelberg Engineering in Lübeck Germany Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo SPECTRALIS OCT2 Module Improves Speed and Efficiency on the International Space Station Toward a multimodal fusion of layered cultural object images: complementarity of optical coherence tomography and terahertz time-domain imaging in the heritage field Optical coherence tomography imaging in keratoconus https://doi.org/10.1111/cxo.12880 Bacillary layer detachment: a novel optical coherence tomography finding as part of blunt eye trauma

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    1. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson
    2. Rox and I would like to take this opportunity to thank SPIE, program track chairs, conference chairs, and all of you in the com¬munity for the opportunity and the privilege to serve as co-chairs of BiOS all these years.
      By James G. Fujimoto
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      By Jay S. Duker
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    10. The initiation of our first U.S. based home OCT clinical trial is an important step towards bringing this leading-edge technology to eAMD patients, their caregivers, and the eye care community...Our collaboration with Wasatch Photonics will continue to be instrumental to our organization as the U.S. Food and Drug Administration (FDA) recently granted our Home Optical Coherence Tomography (OCT) System with ‘Breakthrough Device Designation’, a program designed to expedite patient access to novel technologies.
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