1. Recent Articles From Around The Web

    1. The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction

      The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction

      Background Patients with ST-elevation Myocardial Infarction treated by primary percutaneous coronary intervention (PPCI) experience drastic hemodynamic systemic changes (i.e., blood pressure) during the different phases of the procedure. Optical coherence tomography is often used to unveil the underlying cause of STEMI (pre-PCI) and to optimize stent implantation (post-PCI). The impact of blood pressure variability on coronary lumen remains uncertain. This study aimed to investigate the relationship between blood pressure variability, before and after PCI, and coronary arterial lumen dimensions of the infarct-related artery. Methods We measured systolic, diastolic and mean arterial blood pressure (SBP, DBP, and MAP; respectively) at ...

      Read Full Article
    2. Clinical diversity in macular corneal dystrophy: an optical coherence tomography study

      Clinical diversity in macular corneal dystrophy: an optical coherence tomography study

      Purpose To characterise the corneal deposits of macular corneal dystrophy and correlate with high-resolution optical coherence tomography (OCT). Methods A total of 23 eyes of 15 patients were evaluated for clinical features on slit lamp biomicroscopy, and high-resolution OCT was performed to correlate the clinical findings. The deposits were characterised based upon their location and level in the corneal layers. Results Mean age was 31.5 (Range 20–67) years. The stromal deposits were restricted to central 8 mm in 9 eyes; in the rest of the 14 eyes, the deposits were seen in both central and peripheral cornea. In ...

      Read Full Article
    3. Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT)

      Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT)

      Amblyopia refers to visual impairment resulting from perturbations in visual experience during visual development, typically secondary to strabismus, uncorrected refractive error, and/or deprivation. Amblyopia has traditionally been considered a cortical disease, but the depth of our understanding of this complex neurodevelopmental condition is limited by our ability to appreciate structural pathophysiology in the visual pathway. Recent advances in Optical Coherence Tomography (OCT) have facilitated numerous studies of the structural changes in the retina and optic nerve, thereby expanding our appreciation for the pathogenesis of this condition. In this review, we summarize findings from studies evaluating retinal, retinal nerve fiber ...

      Read Full Article
    4. Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Precis: 3D spectral domain OCT volume scans of the optic nerve head and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Purpose: To report the use of spectral domain optical coherence tomography (OCT) in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Methods: Observational case series. Four consecutive patients with KPro’s were referred for glaucoma evaluation. A comprehensive eye exam was performed which included disc photography, visual field testing, and high-density spectral domain OCT volume scans of the optic ...

      Read Full Article
    5. Velocity range estimation for liquid flow based on optical micro-angiography

      Velocity range estimation for liquid flow based on optical micro-angiography

      Optical micro-angiography (OMAG) is widely used in vivo imaging due to its non-invasive and highly sensitive measurements. It can effectively distinguish flowing and stationary particles for applications such as micro-size blood vessel. However, the detectable flow velocity of OMAG is restricted by the system parameters. Their relationship is usually unknown and thus increase the difficulty of OMAG application on liquid flow measurements. This study for the first time proposes a velocity range estimation formula to quantify the measurable velocity range of liquid flow for the OMAG and the ultrahigh-sensitivity OMAG (UHS-OMAG) methods. The velocity range not only provides rough velocity ...

      Read Full Article
    6. Spectral optical coherence tomography findings in an adult patient with syphilitic bilateral posterior uveitis and unilateral punctate inner retinitis

      Spectral optical coherence tomography findings in an adult patient with syphilitic bilateral posterior uveitis and unilateral punctate inner retinitis

      Purpose To describe the spectral domain optical coherence tomography (SD-OCT) features of a punctate inner retinitis, a rare ocular manifestation of syphilis, in an HIV positive adult patient. Observations In the right eye, SD-OCT images during the active period showed hyperreflectivity of the full thickness of the inner retina, precluding the individualization of the layers. In addition, multifocal areas with higher hyperreflectivity were identified within the affected retina. Once the lesion became inactive, SD-OCT images revealed inner retina layers atrophy, disruption of the ellipsoid layer, and multifocal damage to the retinal pigment epithelium layer. Conclusion and importance Punctate inner retinitis ...

      Read Full Article
    7. In-stent restenosis caused by calcified nodule 11 years after paclitaxel eluting stent implantation treated with drug-coated balloon following rotational atherectom

      In-stent restenosis caused by calcified nodule 11 years after paclitaxel eluting stent implantation treated with drug-coated balloon following rotational atherectom

      n 82-year-old man with dyslipidemia, diabetes mellitus and chronic kidney disease was admitted to our hospital for heart failure. He was treated with 3 paclitaxel eluting stents in the proximal and mid-right coronary artery (RCA) for silent myocardial ischemia 11 years previously. 2 years after the initial procedure, angioplasty was performed for in-stent restenosis (ISR) in the RCA. He had been stable with optimal medical therapy until the present admission. After admission, CAG upon stabilization of heart failure with medical therapy showed ISR in the mid-RCA (Fig. 1 a). On the first session, neither a 1.0-mm balloon nor imaging ...

      Read Full Article
    8. Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology

      Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology

      ptical coherence tomography (OCT) is a coronary artery imaging technique with high resolution. Second-generation frequency-domain OCT (FD-OCT) technology allows safer and faster clinical application compared with first-generation time-domain OCT (TD-OCT). Only limited validation studies compare FD-OCT with other modes of analysis: histology, which is the current gold standard, and intravascular ultrasound (IVUS). This study therefore aims to demonstrate the accuracy of FD-OCT images compared with IVUS and histology. FD-OCT and IVUS images were acquired from 203 segments from 31 coronary arteries obtained at autopsy from 20 cadavers. Of these, 30 randomly-selected pairs were used to create three classifications of plaque ...

      Read Full Article
    9. Longitudinal vasculature changes in branch retinal vein occlusion with projection-resolved optical coherence tomography angiography

      Longitudinal vasculature changes in branch retinal vein occlusion with projection-resolved optical coherence tomography angiography

      Purpose To analyze vascular changes in branch retinal vein occlusion (BRVO) using projection-resolved optical coherence tomography angiography (PR-OCTA). Methods We reviewed 30 consecutive eyes of 30 cases with BRVO retrospectively. PR-OCTA was performed during the acute, intermediate, and remission phases when anti-vascular endothelial growth factor drugs suppress cystic changes. The main outcome measures were vessel density (VD) and retinal thickness changes in the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Results The VDs did not change longitudinally in the SCP and DCP during the follow-up period. The VD was significantly ( p  = 0.0105) greater ...

      Read Full Article
    10. Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography

      Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography

      Purpose : To assess retinal vascular reactivity in healthy controls and subjects with diabetic retinopathy (DR). Methods : A total of 22 healthy control eyes and 16 eyes with DR were enrolled. Images were acquired using a commercially available swept-source optical coherence tomography angiography (SS-OCTA) system. Three conditions were tested for each patient (hyperoxia, hypercapnia, and room-air) by employing a non-rebreathing apparatus that delivered appropriate gas mixtures (100% O 2 , 5% CO 2 , room air). Vessel skeleton density (VSD) and vessel diameter index (VDI) were compared between the conditions using mixed-model ANOVA adjusting for age and hypertension. Significant gas or interaction effects ...

      Read Full Article
    11. Identification of separated lenticular planes using optical coherence tomography

      Identification of separated lenticular planes using optical coherence tomography

      Purpose: To discuss how optical coherence tomography can be used to identify separated lenticular planes during small incision lenticule extraction (SMILE). Methods: SMILE procedures were performed on 26 eyes of 13 patients. An anterior segment optical coherence tomography examination was performed after laser scan. Anterior segment optical coherence tomography examinations were conducted again both after separation of the anterior lenticular plane in the right eye and after separation of the posterior lenticular plane in the left eye. Lenticule extraction was then completed, followed by another anterior segment optical coherence tomography examination. Anterior segment optical coherence tomography was also conducted on ...

      Read Full Article
      Mentions: Fudan University
    12. Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives a 2019 NIH Grant for $396,887 for Noninvasive Assessment of the Cornea by Diffusion OCT. The principal investigator is Andrew Rollins. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Keratoconus is a degenerative disease of the cornea that is a major cause of reduced vision-related quality of life in the United States, often leading to corneal transplantation. Ectasia after refractive surgery is a vision-threatening complication that can occur in apparently low-risk patients despite current screening technology. The biomechanical properties of the cornea play a central ...

      Read Full Article
    13. Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Receives a 2019 NIH Grant for $766,562 for Intraoperative OCT Guidance of Intraocular Surgery. The principal investigator is Joseph Izatt. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. This is a resubmission application for a Bioengineering Research Partnership (BRP) which brings together a highly collaborative and experienced team of engineers and ophthalmic surgeons to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon’s current stereo microscopic view of ocular structures by continuing to integrate optical coherence tomography (OCT ...

      Read Full Article
    14. Massachusetts Institute of Technology Receives NIH Grant for Novel Diagnostics with Optical Coherence Tomography.

      Massachusetts Institute of Technology Receives NIH Grant for Novel Diagnostics with Optical Coherence Tomography.

      Massachusetts Institute of Technology Receives a 2019 NIH Grant for $349,765 for Novel Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1985 and ends in 2020. Below is a summary of the proposed work. This proposal is a resubmission of a competing renewal application for an ongoing collaborative program among investigators at the Massachusetts Institute of Technology, New England Eye Center and University of Pittsburgh Medical Center Eye Center. This is a multidisciplinary program which integrates imaging technology research, clinical and small animal imaging studies. The specific aims are: Aim 1. Next ...

      Read Full Article
    15. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (6 articles) National Institutes of Health
    2. (4 articles) Center for Ophthalmic Optics and Lasers
    3. (4 articles) University of Miami
    4. (4 articles) Oregon Health & Science University
    5. (4 articles) Duke University
    6. (3 articles) Massachusetts Eye and Ear Infirmary
    7. (3 articles) Harvard University
    8. (2 articles) Institute of Applied Physics
    9. (2 articles) VU University Amsterdam
    10. (2 articles) Nanyang Technological University
  3. People in the News

    1. (4 articles) David Huang
    2. (2 articles) Ruikang K. Wang
    3. (2 articles) Teresa C. Chen
    4. (2 articles) Benjamin J. Vakoc
    5. (2 articles) Brett E. Bouma
    6. (2 articles) Yonghong He
    7. (2 articles) Johannes F. de Boer
    8. (2 articles) Mohamed Abou Shousha
    9. (2 articles) Joseph A. Izatt
    10. (2 articles) Philip J. Rosenfeld
    11. (2 articles) Francesco Bandello
    12. (2 articles) Linbo Liu
    13. (2 articles) Cynthia A. Toth
    14. (1 articles) Giovanni Gregori
    15. (1 articles) Thomas E. Milner
  4. OCT Companies in the News

    1. (3 articles) Carl Zeiss Meditec
    2. (1 articles) Optovue
    3. (1 articles) Sciton
    4. (1 articles) Siemens
    5. (1 articles) Nidek
    6. (1 articles) Bioptigen
    7. (1 articles) Heidelberg Engineering
    8. (1 articles) PhotoniCare
    9. (1 articles) OncoRes Medical
    10. (1 articles) Michelson Diagnostics
  5. Picture Gallery

    Innovative use of optical coherence tomography catheter via nipple orifice: a case report of first intraductal images of florid ductal hyperplasia PhD Student and Postdoctoral Associate Positions at the University of Massachusetts Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography New Hope for Port Wine Stain Patients from A Novel Image-Guided Treatment HKU Medical Artificial Intelligence Laboratory Programme employs AI as new testing ground for more optimal and efficient clinical practice of eye diseases Rutgers Scientist Creates “Virtual Biopsy” Device to Detect Skin Tumors Laser brain cancer surgery in a xenograft model guided by optical coherence tomography Compressed sensing spectral domain optical coherence tomography with a hardware sparse-sampled camera Two thousand optometrists geared up for OCT at Specsavers Post-Doctoral Researcher Opening at Department of Physics, University of Coimbra, Portugal The Bruno Lumbroso Lecture at the 7th International Congress on OCT Angiography, Rome, December 13 and 14, 2019 Interference effects in quantum-optical coherence tomography using spectrally engineered photon pairs
  6. Recent Quotes

    1. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    2. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    3. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    4. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    5. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    6. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden
    7. We are very excited and honored to partner with the team at Adachi. Adachi’s strong market presence in Otolaryngology, as well as their expertise in navigating Japanese regulatory and reimbursement pathways, will ensure a powerful launch of the TOMi Scope in the Japanese marketplace. We see this partnership as further validation of our technology and its potential to impact healthcare in a meaningful way. We look forward to a long and fruitful relationship with Adachi.
      By Ryan L. Shelton
    8. You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube...Many lesions in the mouth have been re-mineralized and...no longer need inter­vention,” said Fried. “Dentists have trouble telling the difference between active and arrested lesions; this new technology has the potential of differentiating them.
      By Daniel S. Fried
    9. OCT [already] has changed the practice of ophthalmol­ogy...It’s been very successful for retinal imaging...and it’s also very promising for dentistry...If the dentist doesn’t know if [a lesion] is active or arrested,” said Fried, “with OCT, you can actually see the lesion struc­ture, how deep it is and if it has a definitive surface zone suggesting that remineralization has occurred.
      By Daniel S. Fried
    10. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson