1. Featured Articles

    1. Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      A postdoctoral or research scientist position is available in Larina Lab in the Department of Molecular Physiology and Biophysics at the Baylor College of Medicine, Houston, TX to develop functional optical imaging methods toward investigation of developmental mechanisms. We are a dynamic highly collaborative team of optical engineers and biologists, investigating biomechanical aspects of biological processes in mouse models of human disorders. Our studies bring together optical system design, OCT, confocal/multiphoton microscopy, optogenetics, technology development in functional optical imaging and data processing (4D angiography, cilia beat mapping, cardiodynamic analysis, elastography), vital fluorescent reporters, genetic mouse models of human disorders ...

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      Mentions: Baylor College of Medicine Irina V. Larina

    2. Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      Explore jstage.jst.go.jp Cardiology
      Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      The microscopic tissue structure and organization influence the polarization of light. Intravascular polarimetry leverages this compelling intrinsic contrast mechanism by using polarization-sensitive optical frequency domain imaging to measure the polarization properties of the coronary arterial wall. Tissues rich in collagen and smooth muscle cells appear birefringent, while the presence of lipid causes depolarization, offering quantitative metrics related to the presence of important components of coronary atherosclerosis. Here, we review the basic principles, the interpretation of polarization signatures, and first clinical investigations of intravascular polarimetry and discuss how this extension of contemporary intravascular imaging may advance our knowledge and improve clinical ...

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      Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University

    3. Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      Explore jstage.jst.go.jp Cardiology
      Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      I ntravascular optical coherence tomography (OCT) is a light-based imaging modality that enables detailed visualization of the intraluminal structures in coronary arteries. High-resolution (10–20μm) cross-sectional images are generated by measuring the echo time delay and intensity of light that is reflected or backscattered from the internal structures in tissues.1,2 OCT is clinically useful during percutaneous coronary intervention (PCI) to assess lesion severity, optimize stent implantation, and characterize atherosclerotic plaques, including the identification of thin-cap fibroatheroma (TCFA) and lipid-rich plaques, which are reportedly responsible for periprocedural complications. OCT can also be used to assess the mechanism for ...

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      Mentions: Toshiro Shinke

    4. Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

      Explore ScienceDirect Ophthalmology
      Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs

      Abstract Purpose To compare the diagnostic performance of human gradings versus predictions provided by a machine-to-machine (M2M) deep learning (DL) algorithm trained to quantify retinal nerve fiber layer (RNFL) damage on fundus photographs. Design Evaluation of a machine learning algorithm. Methods A M2M DL algorithm trained with RNFL thickness parameters from spectral-domain optical coherence tomography was applied to a subset of 490 fundus photos of 490 eyes of 370 subjects graded by two glaucoma specialists for the probability of glaucomatous optical neuropathy (GON), and estimates of cup-to-disc (C/D) ratios. Spearman correlations with standard automated perimetry (SAP) global indices were ...

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      Mentions: Duke University Felipe A. Medeiros

    5. Deep learning-based automated detection of retinal diseases using optical coherence tomography images

      Explore OSA | OSA Publishing Ophthalmology
      Deep learning-based automated detection of retinal diseases using optical coherence tomography images

      Retinal disease classification is a significant problem in computer-aided diagnosis (CAD) for medical applications. This paper is focused on a 4-class classification problem to automatically detect choroidal neovascularization (CNV), diabetic macular edema (DME), DRUSEN, and NORMAL in optical coherence tomography (OCT) images. The proposed classification algorithm adopted an ensemble of four classification model instances to identify retinal OCT images, each of which was based on an improved residual neural network (ResNet50). The experiment followed a patient-level 10-fold cross-validation process, on development retinal OCT image dataset. The proposed approach achieved 0.973 (95% confidence interval [CI], 0.971–0.975) classification ...

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      Mentions: Florida International University

    6. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Explore IEEE Xplore Cardiology
      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between two adjoining OCT A-line datasets. By interpretation of the velocity field as measured around the zero phase shift, the flow direction at specific angles can be qualitatively estimated. Imaging experiments ...

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      Mentions: Robert A. Huber Gijs van Soest Anton F. W. van der Steen

    8. Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      Explore OSA | OSA Publishing
      Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      There exists an unmet need for an optical coherence tomography (OCT) delivery scheme that is simple, robust, and applicable to general surgical applications. To deliver the beam in a narrow form factor, optical borescopes present an attractive potential solution. We present a method for enabling endoscopic delivery of OCT using a handheld rigid borescope adapted to a low-cost OCT engine. The system reduces the distal profile of the scanner, enabling application of the system in otherwise hard-to-access regions. The clinical potential of this design is demonstrated through real-time quantification of articular cartilage thickness, a primary biomarker of joint health during ...

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      Mentions: Duke University Adam Wax

    9. Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging

      Explore Home - Springer Cardiology
      Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging

      The three-dimensional reconstruction of optical coherence tomography and optical frequency domain imaging (3D-OCT/OFDI) helps optimize bifurcation percutaneous coronary interventions (PCIs) with side branch (SB) dilatation by identifying the optimal rewiring position. 3D-OCT/OFDI’s diagnostic performance for assessing the rewiring position into a jailed SB is unknown. We retrospectively evaluated the diagnostic performances of a conventional (ver. 1.1) and a new (ver. 1.2) online 3D-OFDI reconstruction system based on an offline 3D reconstruction system’s performance. We analyzed 45 patients’ 52 OFDI pullbacks with main vessel stenting followed by rewiring into a jailed SB for coronary bifurcation ...

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      Mentions: Takayuki Okamura

    10. Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm

      Explore Optical Coherence Tomography News Other Business News , Tunable Sources
      Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm

      Thorlabs announced today that it has released next-generation versions of its MEMS-VCSEL Swept-Wavelength Laser Sources. The new SL10 series, centered at 1060 nm, complements the already well-established SL13 series at 1300 nm and is available with four different sweep rates ranging from 60 kHz to 400 kHz. Based on a patented microelectromechanical system (MEMS) tunable vertical cavity surface emitting laser (VCSEL), these light sources feature a record-breaking coherence length of over 100 mm and include an active power control that maintains constant output power over the lifetime of the laser. All drive electronics and trigger signals needed to seamlessly integrate ...

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      Mentions: Thorlabs

    11. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Explore European Respiratory Journal Pulmonology
      Excess mucus viscosity and airway dehydration impact COPD airway clearance

      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical coherence tomography. Mucus changes in primary human airway epithelial cells and ex vivo ferret airways were assessed by histology and particle tracking microrheology. Linear mixed models for repeated measures identified ...

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      Mentions: Guillermo J. Tearney Johns Hopkins University Massachusetts General Hospital

    13. Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography

      Explore Nature Publishing Group
      Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography

      The non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength range, we used a combination of zero-delay acquisition and focus tracking that ensures optimal system sensitivity at any depth inside the sample. Subsequently, we developed an analysis model to adequately ...

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      Mentions: University of Twente Nienke Bosschaart

    14. Does lining class-II cavities with flowable composite improve the interfacial adaptation?

      Explore Taylor & Francis Online Dentistry
      Does lining class-II cavities with flowable composite improve the interfacial adaptation?

      The objective of this study was to assess in-vitro interfacial cavity adaptation of different adhesive/composites systems in class-II restoration using SS-OCT and to confirm the findings with a confocal laser scanning microscope (CLSM). Standardized rectangular-shaped class-II cavities were prepared on 24 extracted human molar teeth, bonded with adhesive and lined with flowable composite. Cavities were further restored by bulk filling using packable composite. Specimens were divided into four groups ( n  = 7) according to restorative materials used; PrimeFil with Estelite Posterior composites (PF; Tokuyama Dental), Clearfil Tri-S Bond Plus with Majesty LV flowable and Majesty Posterior composites (TS; Kuraray Noritake ...

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      Mentions: University of Washington Alireza Sadr Junji Tagami

    15. Automatic fibroatheroma identification in intravascular optical coherence tomography volumes

      Explore Home - Springer Cardiology
      Automatic fibroatheroma identification in intravascular optical coherence tomography volumes

      Coronary heart disease is the most common type of heart disease that leads to heart attacks. The identification of vulnerable plaques, especially the thin-cap fibroatheroma (TCFA), is crucial to the diagnosis of coronary artery disease. Intravascular optical coherence tomography (IVOCT), an emerging imaging modality, has been proven to be useful for the identification of vulnerable plaques. In this work, we propose an approach to identify the volumes with fibroatheroma frames automatically. In the proposed method, we first detect the lumen using a graph-search based method from unfolded images. Then a region of interest starting from the lumen boundary is cropped ...

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      Mentions: National University of Singapore Wakayama Medical University Chinese Academy of Sciences

    16. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Explore LWW Online Otolaryngology
      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney

    17. Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      Explore Healio.com Ophthalmology
      Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

      BACKGROUND AND OBJECTIVE: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease. PATIENTS AND METHODS: A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties. RESULTS: This study included 16 patients. Texture was heterogeneous in all eyes in the SC and VKH groups, and in four eyes (40%) in the APMPPE group. Most ...

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    18. Ph.D. positions in Optical Imaging and Vision Science at Indiana University Bloomington

      Explore Optical Coherence Tomography News Jobs & Studentships
      Ph.D. positions in Optical Imaging and Vision Science at Indiana University Bloomington

      Two Ph.D. positions are available in Dr. Tankam’s laboratory in the Frontiers of Optical Imaging and Biology at Indiana University School of Optometry. The group focuses on developing cutting-edge optical imaging systems, including high-resolution optical coherence tomography and fluorescence microscopy, to enable new investigations in the biomedical research field. The group uses a translational approach to study disease mechanisms; from the fundamental understanding of biological processes involved in normal and pathological conditions in animal models to the early diagnostic and monitoring of disease progression in human subjects. The laboratory is looking for highly motivated students from various background ...

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      Mentions: Indiana University

    19. Cardiovascular OCT Imaging (Textbook)

      Explore Home - Springer Cardiology , Textbooks
      Cardiovascular OCT Imaging (Textbook)

      This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    20. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      Explore OSA | OSA Publishing
      Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      We report the use of an electrically tunable lens (ETL) in a 1.3 μm spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral blood flow imaging of all cortical layers by stitching the OCTA images automatically captured at six focal depths. Capillary vasculature and axial blood flow velocity were revealed in distinctive cortical ...

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      Mentions: University of Washington Ruikang K. Wang
    21. See all articles

  2. Recent Articles From Around The Web

    1. Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Explore Infinite Science Publishing NDE/NDT
      Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.

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      Mentions: Gereon Hüttmann University of Lübeck

    2. Neoatherosclerosis　― Long-Term Assessment of Bioresorbable Vascular Scaffold ―

      Explore jstage.jst.go.jp Cardiology
      Neoatherosclerosis　― Long-Term Assessment of Bioresorbable Vascular Scaffold ―

      Although metallic stents improved the safety and efficacy of percutaneous coronary intervention (PCI), even the latest generation of drug-eluting stents (DES) is still limited by several factors. The limitations of DES are mainly related to the permanent metallic caging in vessel, chronic inflammatory response to the polymer and adverse effects of antiproliferative drug on endothelial tissue, leading to impaired physiological vasomotor response and late stent-related adverse events such as stent thrombosis and neoatherosclerosis. Bioresorbable vascular scaffold (Absorb BVS; Abbott Vascular) was designed to overcome these drawbacks of DES by disappearing from the vessel wall. Absorb BVS, however, was withdrawn from ...

      Read Full Article

    3. Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―

      Explore jstage.jst.go.jp Cardiology
      Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―

      Background: Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear. Methods and Results: OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina (EEM) borders (76% vs. 65.5%); AC-OCT enabled larger EEM arc detection compared with C-OCT (174.2±58.7° vs. 137.5±57.9°; P<0.001). There was poor ...

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      Mentions: Imperial College London Leiden University University College London

    4. Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses

      Explore ScienceDirect Developmental Biology , Ophthalmology
      Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses

      The eye lens displayes a variety of phenotypes in the wake of genetical modifications or environmental influences. Therefore, a high-resolution in vivo imaging method for the lens is desirable. Optical coherence tomography (OCT) has become a powerful imaging tool in ophthalmology, especially for retinal imaging in small animal models such as mice. Here, we demonstrate an optimized approach specifically for anterior eye segment imaging with spectral domain OCT (SD-OCT) on several known murine lens cataract mutants. Scheimpflug and histological section images on the same eye were used in parallel to assess the observed pathologies. With SD-OCT images, we obtained detailed ...

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    5. Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

      Explore Eye and Vision Ophthalmology
      Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

      Background Diabetic retinopathy (DR) is a leading cause of vision loss in adults. Currently, the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography. With the introduction of optical coherence tomography angiography (OCTA), it may serve as a potential rapid, non-invasive imaging modality as an adjunct. Main text Recent studies on the role of OCTA in DR include the use of vascular parameters e.g., vessel density, intercapillary spacing, vessel diameter index, length of vessels based on skeletonised OCTA, the total length of vessels, vascular architecture and area of the foveal avascular zone. These quantitative ...

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      Mentions: Singapore Eye Research Institute

    6. Optical coherence tomography allows 3D reconstruction of ablation lesions

      Explore Journals Cardiology
      Optical coherence tomography allows 3D reconstruction of ablation lesions

      Radiofrequency catheter ablation (RFA) is an effective interventional treatment for atrial fibrillation. However, the immediate effect of RFA on the tissue is not directly visualized. This is a key limitation as only acute electrical measurements are taken into account and the atrial wall structure or ablation lesion form are neglected. Optical coherence tomography (OCT) is an imaging technique that uses light to capture histology-like images with a moderate penetration depth of 1–3 mm in the cardiac tissue. It is well-established to characterize plaques in patients with coronary artery disease. Therefore, it might also be used for high-precision imaging of ...

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    9. Early detection of enamel demineralization by optical coherence tomography

      Explore Nature Publishing Group Dentistry
      Early detection of enamel demineralization by optical coherence tomography

      Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of ...

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      Mentions: National Taiwan University Meng-Tsan Tsai Chang Gung University

    10. Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification

      Explore Nature Publishing Group
      Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification

      Measurement of blood oxygen saturation ( s O 2 ) by optical imaging oximetry provides invaluable insight into local tissue functions and metabolism. Despite different embodiments and modalities, all label-free optical-imaging oximetry techniques utilize the same principle of s O 2 -dependent spectral contrast from haemoglobin. Traditional approaches for quantifying s O 2 often rely on analytical models that are fitted by the spectral measurements. These approaches in practice suffer from uncertainties due to biological variability, tissue geometry, light scattering, systemic spectral bias, and variations in the experimental conditions. Here, we propose a new data-driven approach, termed deep spectral learning (DSL), to ...

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      Mentions: Boston University Ji Yi

    11. AS-OCT Guided Treatment Of Diffuse Conjunctival Squamous Cell Carcinoma With Resection ...

      Explore Medical Journals Publisher Ophthalmology
      AS-OCT Guided Treatment Of Diffuse Conjunctival Squamous Cell Carcinoma With Resection ...

      Purpose: To evaluate the efficacy of combined limited surgical resection, amniotic membrane graft and topical mitomycin C in treatment of diffuse conjunctival squamous cell carcinoma (CSCC) diagnosed and followed up by anterior segment optical coherence tomography (AS-OCT). Subjects and methods: A prospective study was performed on 24 eyes with diffuse CSCC. Fifteen eyes underwent lesion limited resection followed by postoperative topical mitomycin C 0.04% eye drop (MMC group) while nine eyes underwent complete excision and cryotherapy (no MMC group). Amniotic membrane graft was applied in all cases. The diagnosis was based on clinical and AS-OCT specific criteria of CSCC ...

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    12. The Eyes Behind Surgical Robots

      Explore Photonics.com Ophthalmology
      The Eyes Behind Surgical Robots

      By the turn of the century, Intuitive Surgical Inc.’s da Vinci surgical system, which was approved by the FDA in 2000, was used for general laparoscopic surgical procedures and even cardiovascular surgeries — a high watermark in the early years. The system is still in wide use today. Intuitive Surgical Inc.’s da Vinci is among the most well-known surgical robotic systems. Courtesy of Intuitive Surgical Inc. Fast forward two decades, and today’s surgical robots are more precise and user-friendly, and capable of highly delicate microsurgeries, thanks to advancements in optical technology that have allowed for safe and effective ...

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    14. Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

      Explore Hindawi Publishing Corporation Ophthalmology
      Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

      Background . The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP). Methods . This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes. Heterogeneity was evaluated using the chi-squared test based on the values of and I 2 . Results . Seven studies were included in this meta-analysis. The vessel density values measured in the superficial ...

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    15. The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      Purpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 5–18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20 ...

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      Mentions: Sun Yat-Sen University
      16. See all articles
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    Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ― Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs Deep learning-based automated detection of retinal diseases using optical coherence tomography images Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography Robot prototype shows promise for microsurgery on eyes and aneurysms Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm Excess mucus viscosity and airway dehydration impact COPD airway clearance Optovue's 10-Part Video Series on Ophthalmic OCT Interpretation.

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    1. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    2. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
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    3. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
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    4. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    5. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
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    6. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
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    7. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
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    8. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    9. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    10. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney