1. Recent Articles From Around The Web

    1. Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography

      Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography

      Biomechanical properties of corneal scar are strongly correlated with many corneal diseases and some types of corneal surgery, however, there is no elasticity information available about corneal scar to date. Here, we proposed an acoustic radiation force optical coherence elastography system to evaluate corneal scar elasticity. Elasticity quantification was first conducted on ex vivo rabbit corneas, and the results validate the efficacy of our system. Then, experiments were performed on an ex vivo human scarred cornea, where the structural features, the elastic wave propagations, and the corresponding Young's modulus of both the scarred region and the normal region were ...

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    2. Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

      Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

      Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) of filtering blebs using anterior segment (AS-) OCTA and their association with surgical outcomes. This study included 57 eyes of 53 patients who had undergone trabeculectomy with mitomycin C. AS-OCTA images of filtering bleb were acquired at 3 and 6 months after trabeculectomy, and at 1 month in possible cases. CAAs, regions where complete blood flow was not depicted ...

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    3. Quantitative Analysis of Radial Peripapillary Capillary Network in Patients With Papilledema Compared with Healthy Subjects Using Optical Coherence Tomography Angiography

      Quantitative Analysis of Radial Peripapillary Capillary Network in Patients With Papilledema Compared with Healthy Subjects Using Optical Coherence Tomography Angiography

      Background: To quantitatively compare the peripapillary microvascular network between patients with papilledema and healthy subjects using swept source optical coherence tomography angiography. Methods: In this retrospective observational study, patients with papilledema secondary to idiopathic intracranial hypertension and healthy controls were imaged with swept source optical coherence tomography angiography (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA) using a 6 × 6 mm scan pattern centered on the optic disc. The capillary perfusion density (CPD) and capillary flux index (CFI) of the radial peripapillary capillaries in the retinal nerve fiber layer (RNFL) were calculated using Zeiss algorithm. Results: Thirty-nine eyes of 20 ...

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    4. Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurements Using Spectral Domain Optical Coherence Tomography

      Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurements Using Spectral Domain Optical Coherence Tomography

      The objective of the research was to assess the reproducibility of retinal nerve fiber layer (RNFL) and macular thickness using spectral domain optical coherence tomography and to establish whether the same investigator can get the same or similar results when performing the scan thrice in an hour, without reference to the previous scan and the repeat function. Materials and Methods. In this prospective observational study, 200 subjects who fulfilled the inclusion and exclusion criteria were scanned 3 times according to predefined guidelines at 0, 30 and 60 minutes on the same day, by the same investigator, using spectral domain optical ...

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    5. Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging

      Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging

      Glaucoma causes blindness due to the progressive death of retinal ganglion cells. The immune response chronically and subclinically mediates a homeostatic role. In current clinical practice, it is impossible to analyse neuroinflammation non-invasively. However, analysis of vitreous images using optical coherence tomography detects the immune response as hyperreflective opacities. This study monitors vitreous parainflammation in two animal models of glaucoma, comparing both healthy controls and sexes over six months. Computational analysis characterizes in vivo the hyperreflective opacities, identified histologically as hyalocyte-like Iba-1+ (microglial marker) cells. Glaucomatous eyes showed greater intensity and number of vitreous opacities as well as dynamic fluctuations ...

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    6. Impact of Epiretinal Membrane on Optical Coherence Tomography Tools Used for Monitoring Glaucoma

      Impact of Epiretinal Membrane on Optical Coherence Tomography Tools Used for Monitoring Glaucoma

      Background: Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) measurements can be influenced by many factors including the presence of concomitant retinal diseases. The aim of this study it to assess the impact of epiretinal membrane (ERM) on RNFL and GCL assessment using optical coherence tomography (OCT). Methods: GCL, peripapillary RNFL (pRNFL), and Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) thicknesses were analysed using an SD-OCT (Spectralis OCT) in eyes with idiopathic ERM and compared with a control group. Results: 161 eyes were included, 73 eyes in the control group and 88 eyes with idiopathic ERM. The ...

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    7. An Improved Analytical Model of a Spectrometer for Optical Coherence Tomography

      An Improved Analytical Model of a Spectrometer for Optical Coherence Tomography

      We present an improved analytical model of a spectrometer for optical coherence tomography (OCT), which more accurately describes the OCT in-depth sensitivity fall-off. The model considers the intrinsic spectral resolution of the dispersive element and the influence of additional components (inequidistance-correcting prism). The model is validated by experimental data obtained both from other studies and our own experiments. The influence of the frequency response of the CCD electrical circuit and the analog-to-digital converter to the OCT signal fall-off was also detected and was shown to be significant in some cases.

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    8. Comparison of similar Mueller and Jones matrix method in catheter based polarization sensitive optical coherence tomography

      Comparison of similar Mueller and Jones matrix method in catheter based polarization sensitive optical coherence tomography

      Catheter based polarization sensitive optical coherence tomography (PS-OCT) can provide composition information of coronary atherosclerotic plaque beyond the intensity based OCT, but it encounters a notable challenge that is how to reduce polarization properties variations owing to a rapidly rotating optical fiber in the catheter. Similar Jones matrix (SJM) and similar Mueller matrix (SMM) based polarization determination methods can provide a stable phase retardation imaging in a catheter based PS-OCT. In this paper, we systematically contrast SJM and SMM methods. Firstly, we theoretically illustrate the discrepancy between the eigenvalue decomposition in SJM and the polar decomposition in SMM. We find ...

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    9. Optical coherence tomography and visual evoked potential and its relationship with neurological disability in patients with relapsing-remitting multiple sclerosis

      Optical coherence tomography and visual evoked potential and its relationship with neurological disability in patients with relapsing-remitting multiple sclerosis

      Introduction : To evaluate the relationship between retinal nerve fiber layer involvement and visual evoked potential with the neurological disability scale in relapsing remitting multiple sclerosis. Methods : Fifty-two patients diagnosed with relapsing-remitting multiple sclerosis were evaluated for the study. Optical coherence tomography (retinal nerve fiber layer or RNFL and macular volume or MV), pattern visual evoked potential or VEP (latency and P100 wave amplitude), and neurological disability scale (EDSS) were performed. A baseline evaluation was carried out and it was repeated after one year and two years. Results : The baseline values ​​in the retinal nerve fiber layer were 82.5 (75-93 ...

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    10. Circular functional analysis of OCT data for precise identification of structural phenotypes in the eye

      Circular functional analysis of OCT data for precise identification of structural phenotypes in the eye

      Progressive optic neuropathies such as glaucoma are major causes of blindness globally. Multiple sources of subjectivity and analytical challenges are often encountered by clinicians in the process of early diagnosis and clinical management of these diseases. In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) thinning of the optic nerve head, and other clinical parameters. Baseline structural heterogeneity in the eyes can play a key role in the progression of optic neuropathies, and present challenges to clinical decision-making. We generated a dataset of Optical Coherence Tomography (OCT) based high-resolution circular measurements on NRR phenotypes, along with other ...

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    11. Combined anterior segment OCT and wavefront-based autorefractor using a shared beam

      Combined anterior segment OCT and wavefront-based autorefractor using a shared beam

      We have combined an anterior segment (AS) optical coherence tomography (OCT) system and a wavefront-based aberrometer with an approach that senses ocular wavefront aberrations using the OCT beam. Temporal interlacing of the OCT and aberrometer channels allows for OCT images and refractive error measurements to be acquired continuously and in real-time. The system measures refractive error with accuracy and precision comparable to that of clinical autorefractors. The proposed approach provides a compact modular design that is suitable for integrating OCT and wavefront-based autorefraction within the optical head of the ophthalmic surgical microscope for guiding cataract surgery or table-top devices for ...

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    12. Investigation of methods to extract confocal function parameters for the depth resolved determination of attenuation coefficients using OCT in intralipid samples, titanium oxide phantoms, and in vivo human retinas

      Investigation of methods to extract confocal function parameters for the depth resolved determination of attenuation coefficients using OCT in intralipid samples, titanium oxide phantoms, and in vivo human retinas

      The attenuation coefficient provides a quantitative parameter for tissue characterization and can be calculated from optical coherence tomography (OCT) data, but accurate determination requires compensation for the confocal function. We present extensive measurement series for extraction of the focal plane and the apparent Rayleigh length from the ratios of OCT images acquired with different focus depths and compare these results with two alternative approaches. By acquiring OCT images for a range of different focus depths the optimal focus plane difference is determined for intralipid and titanium oxide (TiO 2 ) phantoms with different scatterer concentrations, which allows for calculation of the ...

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    13. The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

      The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

      Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls. Methods: We conducted a literature search through a search of electronic databases to identify studies before 19 June 2021, which compared OCTA parameters in non-diabetic participants with systemic hypertension vs. controls. If the OCTA parameter had a minimum number of 3 ...

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    14. Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery

      Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery

      Purpose: To compare structural diameters of the ellipsoid zone (EZ) and external limiting membrane (ELM) bands on spectral domain-optical coherence tomography (SD-OCT) images between vision-improved (group A) and vision-unimproved (group B) patients, and investigate the connection between these parameters and visual prognosis. Materials and Methods: Forty-five eyes of 43 patients with idiopathic full-thickness macular hole closed after vitrectomy were retrospectively reviewed. Best-corrected visual acuity (BCVA) and SD-OCT were conducted preoperatively and at 1 week, 1 month and 6 months postoperatively. Structural and functional parameters were then measured using ImageJ software. Results: Among structural and functional parameters, the relative reflectivity of ...

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    15. Choroidal Changes in Eyes With Polypoidal Choroidal Vasculopathy After Anti-VEGF Therapy Imaged With Swept-Source OCT Angiography

      Choroidal Changes in Eyes With Polypoidal Choroidal Vasculopathy After Anti-VEGF Therapy Imaged With Swept-Source OCT Angiography

      Purpose: Swept-source optical coherence tomography angiography was used to investigate choroidal changes and their association with pigment epithelial detachments (PEDs) in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors. Methods: Patients with treatment-naïve PCV were included and underwent anti-VEGF therapy. Mean choroidal thickness (MCT), choroidal vascularity index (CVI), and PED volume measurements were obtained before and after treatment. Results: Thirty-four treatment-naïve PCV eyes from 33 patients were included. The PED volume decreased after treatment (P < 0.05). The MCT decreased from 223.0 ± 79.6 µm at baseline to 210.9 ...

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  4. Picture Gallery

    Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study Instructor in Optical Coherence Tomography (OCT) in the Tearney Laboratory Perimeter Medical Imaging AI Reports Third Quarter 2021 Financial Results and Provides Corporate Update 105° field of view non-contact handheld swept-source optical coherence tomography Peer-to-peer technology is very useful for developers of SS-OCT systems Robotically aligned optical coherence tomography with 5 degree of freedom eye tracking for subject motion and gaze compensation Postdoc Position at the University of Southern California MicroPort® Invests ~$58M for 51% of IV-OCT Imaging Start-up Argus Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb Quantitative Analysis of Radial Peripapillary Capillary Network in Patients With Papilledema Compared with Healthy Subjects Using Optical Coherence Tomography Angiography Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurements Using Spectral Domain Optical Coherence Tomography
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu