1. Recent Articles From Around The Web

    1. Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT

      Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT

      Imaging specimens over large scales and with a sub-micron resolution is instrumental to biomedical research. Yet, the number of pixels to form such an image usually exceeds the number of pixels provided by conventional cameras. While most microscopes are equipped with a motorized stage to displace the specimen and acquire the image tile-by-tile, we propose an alternative strategy that does not require any moving part in the sample plane. We propose to add a scanning mechanism in the detection unit of the microscope to collect sequentially different sub-areas of the field of view. Our approach, called remote scanning, is compatible ...

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    2. Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

      Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

      Purpose: The aim of this study is to assess the macular ultrastructure measuring by optical coherence tomography angiography in adult patients with Familial Mediterranean fever. Methods: Participants were 62 Familial Mediterranean fever patients and 54 healthy individuals in control group with similar age and sex. The superficial and deep vascular plexus structures covering the central fovea in an area of 6 mm × 6 mm were measured using AngioVue images taken with optical coherence tomography angiography. Vasculature structure, foveal avascular zone, acircularity index of foveal avascular zone (the ratio of the perimeter of foveal avascular zone and the perimeter of a ...

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    3. Intravascular ultrasound or optical coherence tomography-defined anatomic severity and hemodynamic severity assessed by coronary physiologic indices

      Intravascular ultrasound or optical coherence tomography-defined anatomic severity and hemodynamic severity assessed by coronary physiologic indices

      Introduction and objectives Fractional flow reserve or instantaneous wave-free ratio has become a standard criterion for revascularization . We sought to evaluate the association between intravascular ultrasound (IVUS) or optical coherence tomography (OCT)-derived quantitative plaque characteristics and the severity of physiologic stenosis. Methods A total of 365 stenoses from 330 patients were evaluated. The association between IVUS or OCT-derived parameters and resting physiologic indices (instantaneous wave-free ratio, resting full-cycle ratio, and diastolic pressure ratio) and fractional flow reserve were explored. Results Among the total number of lesions, 50.7% and 58.1% showed an instantaneous wave-free ratio ≤ 0.89 and ...

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    4. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

      Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

      Purpose : Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. Methods : In this retrospective, cross-sectional study, 6 × 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and average flow deficit size. Regions were defined by concentric areas centered on the fovea: a 1-mm-diameter area, 3-mm-diameter ring, 5-mm-diameter area, 5-mm-diameter ring, and 6 × 6-mm whole image. Data were ...

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    5. Reliability of foveal avascular zone metrics automatically measured by Cirrus optical coherence tomography angiography in healthy subjects

      Reliability of foveal avascular zone metrics automatically measured by Cirrus optical coherence tomography angiography in healthy subjects

      Purpose To investigate the reliability of the foveal avascular zone (FAZ) metrics automatically measured using Cirrus optical coherence tomography angiography (OCTA) embedded algorithm compared to human manual measurement. Methods Thirty-five eyes of 35 healthy subjects were enrolled and scanned four times continuously on Zeiss Cirrus HD-OCT 5000. The FAZ metrics (area, circularity and perimeter) of the superficial capillary plexus were measured automatically using the embedded tool and manually measured by the two independent observers using ImageJ. The repeatability of the four scans within all methods of measurements was calculated. The agreement of the manual vs automated measurement was also analyzed ...

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    6. Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Patients undergo collection of tears, saliva, buccal mucosa, and fecal samples before stem cell transplant, at 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients also undergo collection of blood samples before stem cell transplant, at 1-2, 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients may undergo skin and mouth biopsy over 15-30 minutes before stem cell transplant, at 2-3 and 12 months after stem cell transplant, and at cGVHD onset. Patients undergo digital pictures of the eyes, mouth and skin, and optical ...

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    7. Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      The advent of optical coherence tomography angiography (OCTA), a relatively new tool to image the retinal and choroidal microvasculature with depth-resolved capability, has been met with great excitement by some ophthalmologists. This noninvasive technology is a potentially valuable instrument to differentiate flow impairment in the superficial vs deep retinal capillary plexus, and it can quantify nonperfusion in eyes with retinal vascular disease. Moreover, OCTA has advanced understanding of the microvascular morphology of choroidal neovascularization and has demonstrated its various growth patterns.  It also has highlighted the potential importance of inner choroidal flow impairments associated with the development and progression of ...

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    8. Artificial Intelligence and Healthcare: Products and Procedures

      Artificial Intelligence and Healthcare: Products and Procedures

      This paper focuses on statutory regulation of learning machines that qualify as medical devices. After a brief case study, the article takes a procedural perspective and presents the main features of the European regulatory framework that applies to medical devices in order to identify the regulatory peculiarities in the use of machine learning. In this context, the Chapter will analyse the immanent risks of machine learning applications as medical devices as well as the role of machine learning in their regulation. The overall finding is that due to its lack of expertise and material equipment the state activates private companies ...

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    9. Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      The overall goal of this book is to provide the reader with an understanding of the new minimally invasive techniques that are available for the purpose of diagnostic imaging in dentistry and to explain their impact on clinical practice. The book concentrates very much on those techniques that are clinically applicable and useful to dentists NOW, although it also provides a fascinating view to the future. The chapters are divided according to the major clinical topics in dentistry. Each chapter provides considerable visual content, including flow charts, schematics, and photographs. The principles of the technologies presented are discussed in an ...

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    10. Machine learning, imaging technique may boost colon cancer diagnosis

      Machine learning, imaging technique may boost colon cancer diagnosis

      Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...

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    11. Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Background/Objectives Choroidal thinning has been suggested in Leber’s hereditary optic neuropathy (LHON). No study has been conducted of the choroid in relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought to measure choroidal thickness in chronic LHON and to correlate thickness changes with the RGC-IPL. Subjects/Methods Chronic LHON, 11778 mitochondrial DNA (mtDNA) mutation, patients (26 eyes; mean age: 35.1 ± 16.1 years) were prospectively recruited at Doheny Eye Center, University of California Los Angeles from March 2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 ± 11.1 years) were enroled ...

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    12. Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Combined central retinal artery and vein occlusion is an uncommon vascular pathology that can cause severe and permanent visual impairment. Optical coherence tomography angiography (OCTA) is a newly available, noninvasive imaging technique that can potentially improve understanding of the structural and vascular implications and prognosis of this infrequent pathology. The present report describes the principal clinical findings in a case of combined central retinal artery and vein occlusion, as detected by the different imaging modalities available in a tertiary referral hospital. OCTA wide-field montage images identified an extensive area of nonperfusion on the macula with involvement of the entire retina ...

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    13. Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Optical coherence tomography angiography (OCT-A) represents the most recent modality in retinal imaging for non-invasive and depth-selective visualization of blood flow in retinal vessels. With regard to quantitative OCTA measurements for early detection of subclinical alterations, it is of great interest, which intra- and extra-ocular factors affect the results of OCTA measurements. Here, we performed OCTA imaging of the central retina in 65 eyes of 65 young healthy female and male participants and evaluated individual physical fitness levels by standard lactate diagnostic using an incremental maximal performance running test. The main finding was that OCTA measurements of the foveal avascular ...

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    14. Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      At clinical conferences and in publications, use of the term real world is widespread. It describes physicians’ accumulated experience in treating patients. It is contrasted with academic trials. Randomized clinical trials differ from practice in that they have fixed prespecified inclusion and exclusion criteria, adherence to a prespecified protocol, and ideally good patient retention. Randomized clinical trials have an advantage against observational studies when comparing treatments because they largely control for confounders, bias, and chance. Patient and treatment selection bias, losses to follow-up, outcome measurement, and imaging variability as well as many other confounding and bias factors can have large ...

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  2. Organizations in the News

    1. (2 articles) Johns Hopkins University
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  5. Picture Gallery

    Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study Duke University Engineering Professor Sina Farsiu Elected Fellow of the IEEE PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital
  6. Recent Quotes

    1. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    2. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    3. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    4. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    5. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    6. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    7. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    8. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    9. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    10. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood