1. Recent Articles From Around The Web

    1. Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Objective: To describe the normative quantitative parameters of macular retinal vasculature and their systemic and ocular associations, using optical coherence tomography angiography (OCTA). Design: Population based cross sectional study SUBJECTS: Adults above 50 years old were recruited from the third examination of the population-based Singapore Malay Eye Study. Methods: All participants underwent standardized comprehensive examination and Spectral domain-OCTA (Optovue, USA) of the macula. OCTA scans with pre-existing retinal disease, macular pathology, and poor quality were excluded. Main outcome measures: Normative quantitative vessel densities of the superficial, deep layer and foveal avascular zone were evaluated. Ocular and systemic associations with macular ...

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    2. Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning

      Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning

      Automatic segmentation and measurement of the choroid layer is useful in studying of related fundus diseases, such as diabetic retinopathy and high myopia. However, most algorithms are not helpful for choroid layer segmentation due to its blurred boundaries and complex gradients. Therefore, this paper aimed to propose a novel choroid segmentation method that combines image enhancement and attention-based dense (AD) U-Net network. The choroidal images obtained from optical coherence tomography (OCT) are pre-enhanced by algorithms that include flattening, filtering, and exponential and linear enhancement to reduce choroid-independent information. Experimental results obtained from 800 OCT B-scans of the choroid layers from ...

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    3. In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

      In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

      A line-shaped beam is useful for increasing the processing speed in laser grooving and scribing. In laser grooving, depth control of the processed structure is important for performing precise processing. In this paper, in-process monitoring of the depth of a structure formed by femtosecond laser processing with a line-shaped beam using swept-source optical coherence tomography (SS-OCT) was demonstrated. In the evaluation of the SS-OCT system, the depth resolution, measurement accuracy, and axial measurable range were 15.8 μm, ±2.5 μm and 5.3 mm, respectively. In laser grooving, the structural shape and the distribution of deposited debris were successfully ...

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    4. The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma

      The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma

      Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG. Methods: In this cross-sectional study, 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation ...

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    5. OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment

      OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment

      Purpose To propose optical coherence tomography angiography (OCT-A) for the follow-up of neovascular age-related macular degeneration (nAMD) treated with a treat-and-extend (T&E) aflibercept regimen to avoid overtreatment. Methods Retrospective, cohort, pilot study. We analysed 16 consecutive-treatment naïve nAMD eyes following up 2-years at the Eye Clinic, Bari, Italy. Intravitreal aflibercept injections in the T&E regimen for no less than 12 months, during which the macula was dry without any sign of intraretinal or subretinal fluid (SRF) at each visit, were performed. Parametric data were evaluated using an analysis of variance (ANOVA); any non-parametric statistical calculations were performed ...

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    6. A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer

      A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer

      Malignancy is one of the consequent driving explanations behind death worldwide, and it is assessed at 9.6 million in 2018. Around 1 out of 6 deaths are the direct result of the malignancy. Clinicians state, that age and breast density are two natural elements resulting in the danger of cancer. The mortality rate brought about by malignant growth in low and focus pay countries is, for the most part, around 70%. Imaging techniques play a vital role in detection, staging, and help in guiding treatment decisions. This review paper presents a comprehensive survey involving a literature study about the ...

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    7. Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System

      Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System

      Cogmedix, a wholly-owned subsidiary of Coghlin Companies, Inc., and provider of FDA -compliant medical device engineering and manufacturing services, is proud to share that longtime customer, Seno Medical Instruments, Inc., has been selected as a GOLD winner for the 2022 Medical Device Excellence Awards in the Radiological, Imaging, and Electromechanical Devices category. This premier award program recognizes medical device companies that have demonstrated outstanding achievement and their contributions to improving the quality of healthcare worldwide. The Imagio� Breast Imaging System Seno Medical, a pioneer in the development of opto-acoustic ultrasound technology, was awarded this prestigious honor for their Imagio® Breast ...

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      Mentions: FDA Seno Medical
    8. Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Purpose: To compare various displacement models using midget retinal ganglion cell to cone (mRGC:C) ratios and to determine viability of estimating RGC counts from optical coherence tomography (OCT)-derived ganglion cell-inner plexiform layer (GCIPL) measurements. Methods: Four Drasdo model variations were applied to macular visual field (VF) stimulus locations: (1) using meridian-specific Henle fiber length along the stimulus circumference; (2) using meridian-specific differences in RGC receptive field and counts along the stimulus circumference; (3) per method (2), averaged across principal meridians; and (4) per method (3), with the stimulus center displaced only. The Sjöstrand model was applied (5 ...

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    9. Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography

      Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography

      Purpose: To evaluate changes in macular blood flow in patients with various stages of diabetic retinopathy (DR) by optical coherence tomography angiography (OCTA). Materials and methods: The data of 94 patients (122 eyes) with type 2 diabetes mellitus admitted from January 2018 to May 2021 were recorded, including 31 patients (42 eyes) with no DR (NDR group), 33 patients (40 eyes) with mild non-proliferative DR (mild NPDR group) and 30 patients (40 eyes) with moderate NPDR (moderate NPDR group). Forty healthy patients (40 eyes) who were examined during the same period were selected as control group. The blood flow densities ...

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    10. Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2

      Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2

      A 50-year-old male was admitted to our hospital with sudden-onset chest pain. He was a current smoker with severe obesity and diabetes. He had a history of drug-eluting stent (DES) implantation in the left anterior descending artery (LAD) and had continuously taken clopidogrel. Eight days prior to admission, polymerase chain reaction testing confirmed that he was positive for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Emergent coronary angiography revealed total occlusion of previously implanted DES in LAD. Optical coherence tomography (OCT) images demonstrated the presence of large white thrombus within the well-expanded DES with homogenous neointima. There were no ...

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    11. Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement

      Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement

      Purpose: Acute idiopathic blind spot enlargement is a rare syndrome that is classified within a spectrum of primary inflammatory choriocapillaropathies with circumscribed outer retinal dysfunction. Observations: We observed coarsening of the choriocapillaris on en-face optical coherence tomography angiography when compared to the fellow eye in a patient with suspected acute idiopathic blind spot enlargement. Conclusions and importance: Increased granularity of the choriocapillaris as imaged by optical coherence tomography angiography may assist in the diagnosis of acute idiopathic blind spot enlargement, particularly during a global pandemic when access to electrodiagnostics is limited. This finding supports the current evidence of choriocapillaris hypoperfusion ...

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    12. Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging

      Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging

      Purpose: This study aimed to investigate anatomic relationships and biomechanics of pressure-dependent trabecular meshwork and distal valve-like structure deformation in normal and glaucoma eyes using high-resolution optical coherence tomography (HR-OCT). Methods: We controlled Schlemm's canal (SC) pressure during imaging with HR-OCT in segments of three normal (NL) and five glaucomatous (GL) ex vivo eyes. The dissected limbal wedges were studied from 15 locations (5 NL and 10 GL). A minimally invasive glaucoma surgery (MIGS)-like cannula was inserted into the SC lumen, whereas the other end was attached to a switch between two reservoirs, one at 0, the other ...

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    13. Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy

      Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy

      Objectives: Cervical radiotherapy can lead to accelerated carotid artery stenosis, increased incidence of stroke, and a higher rate of in-stent restenosis in irradiated patients. Our objective was to reveal the morphological characteristics of radiation-induced carotid stenosis (RICS) and the stent-vessel interactions in patients with previous cervical radiotherapy by optical coherence tomography (OCT). Materials and methods: Between November 2017 and March 2019, five patients with a history of cervical radiotherapy were diagnosed with severe carotid artery stenosis and underwent carotid artery stenting (CAS). OCT was conducted before and immediately after the carotid stent implantation. Two patients received OCT evaluation of carotid ...

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    14. The Effect of Radiologically Isolated Syndrome on Retinal and Choroidal Hemodynamics - An Optical Coherence Tomography Angiography Study

      The Effect of Radiologically Isolated Syndrome on Retinal and Choroidal Hemodynamics - An Optical Coherence Tomography Angiography Study

      Purpose: To evaluate vessel density of retinal plexuses and optic nerve head (ONH) and flow of choriocapillaris to detect possible subclinical retinal microvascular changes associated with the radiologically isolated syndrome (RIS). Materials and Methods: We analyzed 26 eyes of 26 participants diagnosed with RIS and 39 age and sex-matched healthy controls in this prospective, cross-sectional study. The superficial (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) parameters, the flow area of choriocapillaris were evaluated using optical coherence tomography angiography (OCTA). Results: Vessel density (VD) of the parafovea (p = 0.045) and parafoveal subregions (p = 0.049 for superior ...

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    15. The missing link in the recognition of corneal abnormalities

      The missing link in the recognition of corneal abnormalities

      Polarisation-sensitive optical coherence tomography (PS-OCT) is a functional extension of the conventional form of OCT and exploits the polarisation properties of light. According to Dr Ritika Mullick, a fellow in Cornea and Refractive Services at Narayana Nethralaya Hospital, Bangalore, India, this imaging modality can aid the early recognition of disease-related changes before they can be seen topographically. Dr Mullick explained that the human eye is known to have polarisation-altering tissues; using an ultra-high-resolution PS-OCT helps us to study the form birefringence caused by the underlying fibril structures in the corneal stroma. This, in turn, can enable users to detect subnormal ...

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    Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system Fiber-laser platform for precision brain surgery Registration of histological brain images onto optical coherence tomography images based on shape information
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu