1. Feature Of The Week: National Univerity of Singapore Investigates OCT as a Tool for Characterization of Complex Biological Surfaces Including Morphology of Crab Shells

    The advent of scanning electron microscopy has facilitated our understanding of the In recent years, there has been a growing interest in the study of natural biological surfaces in the search for novel solutions in surface engineering design from nature. Most methods for surface imaging of natural biological samples are however, sacrificial and require that samples be sectioned and prepared for characterization. One example is the use of the scanning electron microscope (SEM) to obtain detailed images of microtopography, where a section of the specimen is cut and sputter coated with electrically conductive material like gold or platinum for scanning. These methods may be time consuming and laborious. This presents a challenge for biologists or engineers who are looking at bio-prospecting from a wide diversity of organisms from nature, or in cases where rare biological specimens may be lodged in natural history museums.

    In this article, Optical Coherence Tomography (OCT), an imaging technique that is more commonly used in the field of medical sciences and research, may present an alternative imaging method that is non-invasive. Using four different species of decapod crustacean shells, the technique has enabled surface microtopography to be imaged rapidly and non-intrusively, showing the potential of the imaging tool for characterization of biological surfaces.

    For more information see recent Article. Courtesy of Chin Sing Lim from National University of Singapore. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Feature Of The Week 9/21/14: National Univerity of Singapore Investigates OCT as a Tool for Characterization of Complex Biological Surfaces Including Morphology of Crab Shells

      Feature Of The Week 9/21/14: National Univerity of Singapore Investigates OCT as a Tool for Characterization of Complex Biological Surfaces Including Morphology of Crab Shells

      The advent of scanning electron microscopy has facilitated our understanding of the In recent years, there has been a growing interest in the study of natural biological surfaces in the search for novel solutions in surface engineering design from nature. Most methods for surface imaging of natural biological samples are however, sacrificial and require that samples be sectioned and prepared for characterization. One example is the use of the scanning electron microscope (SEM) to obtain detailed images of microtopography, where a section of the specimen is cut and sputter coated with electrically conductive material like gold or platinum for scanning ...

      Read Full Article
    2. Wavelet transform-based method of compensating dispersion for high-resolution imaging in SDOCT

      Wavelet transform-based method of compensating dispersion for high-resolution imaging in SDOCT

      The axial resolution is an important parameter in Optical Coherence Tomography (OCT). In OCT a broadband light source is used to achieve high axial resolution imaging. However the dispersion results in a broadening of the coherence envelope. The dispersion mismatch between reference and sample arms then needs to be minimized to achieve optimal axial resolution for OCT. In this work we propose a new numerical dispersion compensation method to obtain ultrahigh resolution in SDOCT, in which wavelet transform instead of Fourier transform is used to obtain the signal in different frequency domain. And a series of the phase signals of ...

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    3. Relation of joint spectral and time domain optical coherence tomography (jSTdOCT) and phase-resolved Doppler OCT

      Relation of joint spectral and time domain optical coherence tomography (jSTdOCT) and phase-resolved Doppler OCT

      A variety of promising approaches for quantitative flow velocity measurement in OCT have been proposed in recent years. The question is: Which method gets the most precise flow velocity out of the interference signals detected. We have compared the promising joint spectral and time domain optical coherence tomography (jSTdOCT) and the commonly used phase-resolved Doppler OCT (DOCT) and describe the link between these two proven methods for OCT in the Fourier domain (FD OCT). First, we show that jSTdOCT can be significantly improved by calculating the center of gravity via an unbiased complex algorithm instead of detecting the maximum intensity ...

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    4. Optimization of compute unified device architecture for real-time ultrahigh-resolution optical coherence tomography

      Optimization of compute unified device architecture for real-time ultrahigh-resolution optical coherence tomography

      We propose an optimized signal processing scheme that utilizes the compute unified device architecture (CUDA) for real-time spectral domain optical coherence tomography (OCT). Because linear spline interpolation and the direct spectral reshaping method have low data and control dependencies, these algorithms maximally utilize graphic processing unit (GPU) resources for dispersion control. In addition, data transfer between main memory and GPU, regarded as one of the most wasteful and time-consuming processes in GPU computing, is executed in parallel with the signal processing by overlapping kernel execution and data transfers. Experimental results obtained from application of the proposed scheme to a laboratory ...

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      Mentions: Korea University
    5. Novel insights provided by spectral-domain coherent tomography in pediatric ophthalmology

      Novel insights provided by spectral-domain coherent tomography in pediatric ophthalmology

      Tilted disk syndrome (TDS) is observed in approximately 1 % to 2 % of the population. This percentage appears to be highly variable according to the clinical and imaging features retained for establishing the accurate diagnosis. It is of paramount importance to distinguish isolated tilted optic disk from TDS. This syndrome has a number of alternative nomenclatures such as the nasal fundus ectasia syndrome, inversion of the optic disk, inverse myopia, and dysversion of the optic disk. TDS may be a variant of colobomatous defects. The definition of TDS has often been inaccurate in many studies which did not take account of ...

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    6. A novel method to assess coronary artery bifurcations by OCT: cut-plane analysis for side-branch ostial assessment from a main-vessel pullback

      A novel method to assess coronary artery bifurcations by OCT: cut-plane analysis for side-branch ostial assessment from a main-vessel pullback

      Aims In coronary bifurcations assessment, evaluation of side-branch (SB) ostia by an optical coherence tomography (OCT) pullback performed in the main branch (MB) could speed up lesion evaluation and minimize contrast volume. Dedicated software that reconstructs the cross-sections perpendicular to the SB centreline could improve this assessment. We aimed to validate a new method for assessing the SB ostium from an OCT pullback performed in the MB. Methods and results Thirty-one sets of frequency-domain OCT pullbacks from 28 patients, both from the MB and the SB of a coronary artery bifurcation were analysed. Measurements of the SB ostium from the ...

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    7. Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among 2 spectral domain optical coherence tomography devices

      Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among 2 spectral domain optical coherence tomography devices

      PURPOSE. To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using 2 spectral-domain optical coherence tomography (OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson's disease and healthy controls. METHODS. One-hundred seventy-one eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus® HD-OCT or retinal nerve fiber layer + ganglion cell layer + inner plexiform layer (RNFL-GCL-IPL) using RTVue-100®. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of ...

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    8. Effect of elevated intraocular pressure on the thickness changes of cat laminar and prelaminar tissue using optical coherence tomography

      Effect of elevated intraocular pressure on the thickness changes of cat laminar and prelaminar tissue using optical coherence tomography

      The aim of this study was to examine shape the changes of the lamina cribrosa (LC) under different intraocular pressures (IOPs) with different periods. Images of the optic nerve head were obtained using enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT). After an initial scan of the IOP at native pressure, subsequent scanning was taken when the IOP values reached 40, 60, 80 and 100 mm Hg. Then scans continued with the IOP maintained at 100 mm Hg for 1 hour, 2 hours, 3 hours and 4 hours. The thicknesses of the LC and prelaminar tissue were measured ...

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    9. In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      Purpose: To characterize the in vivo 3D lamina cribrosa (LC) microarchitecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT). Methods: One randomly selected eye from each of 18 healthy subjects was scanned with Cirrus HD-OCT and AO-SDOCT centered on the optic nerve head. LC microarchitecture, imaged by the later device, was semi-automatically segmented and quantified for connective tissue volume fraction (CTVF), beam thickness, pore diameter, pore area and pore aspect ratio. The LC was assessed in central and peripheral regions of equal areas, quadrants and with depth. A linear mixed-effects model weighted by the fraction of visible ...

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    10. Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography

      Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography

      To research retinal stretching or distortion with accommodation, accommodation-induced changes in retinal thickness (RT) in the macular area were investigated in a population of young adults ( n = 23 ) by using a dual-channel spectral domain optical coherence tomography (SD-OCT) system manufactured in-house for this study. This dual-channel SD-OCT is capable of imaging the cornea and retina simultaneously with an imaging speed of 24 kHz A-line scan rate, which can provide the anatomical dimensions of the eye, including the RT and axial length. Thus, the modification of the RT with accommodation can be calculated. A significant decrease in the RT ( 13.50 ...

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    11. High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography and the corresponding vertically sectioned histology of a compound naevus. High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN and 20 MM were studied using HD-OCT and histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, and edged papillae are more often observed in BN, whereas fusion of rete ridges, pagetoid cells and junctional and/or dermal nests with atypical cells are more frequently seen in MM. A high overlap of HD-OCT features in BN and MM was observed and ...

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    12. Latest Data Shows OrbusNeich's COMBO™ Dual Therapy Stent has Excellent

      Latest Data Shows OrbusNeich's COMBO™ Dual Therapy Stent has Excellent

      Prof. Stephen W.L. Lee presented two-year optical coherence tomography (OCT) findings and three-year clinical follow up from the EGO COMBO study, providing further evidence to support the healing benefits of the COMBO Dual Therapy Stent, the only drug eluting stent (DES) with active EPC capture technology. The findings were presented during the 26th Annual Transcatheter Cardiovascular Therapeutics (TCT) meeting, held in Washington, D.C. , September 13-17, 2014 . "This is the first study to assess the healing profile of a dual therapy stent by optical coherence tomography," said Prof. Stephen W.L. Lee , M.D., of the Queen Mary Hospital ...

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    13. New Study Assesses the Utility of Optical Coherence Tomography During Stent Implantation in Primary PCI

      New Study Assesses the Utility of Optical Coherence Tomography During Stent Implantation in Primary PCI

      The first randomized trial to examine serial optical coherence tomography (OCT) in primary percutaneous coronary intervention (PCI) was reported today at the 26 th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. OCT uses light emitted from an intravascular catheter to capture high-resolution cross sectional imaging from within coronary arteries. OCT STEMI is the first randomized multicenter study to examine routine use of OCT guidance during stent implantation in patients with ST-elevation myocardial infarction (STEMI, the most serious form of a ...

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    14. Causes of very late stent thrombosis investigated using optical coherence tomograph

      Causes of very late stent thrombosis investigated using optical coherence tomograph

      Objective Very late stent thrombosis (VLST) remains an unresolved problem, and recent reports have indicated that VLST onset can occur in patients treated with both drug-eluting stents (DES) and bare metal stents (BMS). We evaluated the causes of VLST using optical coherence tomography (OCT). Methods OCT was performed in 22 patients (12 DES-treated patients, 10 BMS-treated patients). Because two instances of VLST occurred simultaneously in one case in the DES group, the DES group comprised 13 lesions, while the BMS group comprised 10 lesions. All struts were counted in each frame, and the proportion of uncovered or malapposed struts was ...

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  2. Organizations in the News

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  6. Picture Gallery

    3D Polymer Weld Seam Characterization Based on Optical Coherence Tomography for Laser Transmission Welding Applications In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography Orion is in Beta - Voxeleron prepares the release of their advanced OCT analysis software Two-dimensional optical coherence tomography for real-time structural dynamical characterization Detection of plasmonic nanoparticles with full field-OCT: optical and photothermal detection St. Jude Medical Announces Launch of OPTIS Integrated System Quantitative measurements of strain and birefringence with common-path polarization-sensitive optical coherence tomography In vivo functional microangiography by visible-light optical coherence tomography Point-of-care and point-of-procedure optical imaging technologies for primary care and global health Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images Automatic detection of bioresorbable vascular scaffold struts in intravascular optical coherence tomography pullback runs Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology
  7. Recent Quotes

    1. Orion is our flagship product targeted at reading centers burdened with the laborious task of manual segmentation, CROs running clinical trials lacking relevant imaging-based biomarkers, and clinical researchers overwhelmed by data and hamstrung by the limited image analysis tools available...It is the most advanced OCT analysis software package available today, and our road map is comprehensive, including change analysis in the next release.
      By Jonathan D. Oakley
    2. As the interventional cardiology landscape has shifted to the treatment of more complex patients, intravascular imaging and fractional flow reserve have emerged as critical tools for enabling physicians to make more informed treatment decisions during PCI... “By integrating these tools directly into cath lab infrastructure, we can enhance access to technology and have them readily available during PCI procedures.
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    4. The hypothesis is that demyelination within the optic nerve and/or transection of axons related to acute inflammation result in retrograde degeneration of the constituent fibers of the optic nerve.
      By Shiv Saidha
    5. When President Bush said he looked Vladimir Putin in the eye and got a sense of his soul, he was actually on to something...The retina is part of the central nervous system, and there is a lot you can learn by looking at it in detail.
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    10. With respect to the planned Axsun divestiture, this decision was driven by our long-term strategy to focus on coronary imaging and physiology leadership, peripheral expansion, profitability and business scale. The Axsun business and financial model is no longer a strategic fit with Volcano. We greatly appreciate the significant contributions of the Axsun team to Volcano over the past several years.
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