1. Recent Articles From Around The Web

    1. Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series

      Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series

      Alopecia areata (AA) is an autoimmune hair loss condition that is difficult to treat and frequently disruptive to the psychosocial well-being of patients. Platelet-rich plasma (PRP) is an innovative therapy that provides concentrated GFs that impart anti-inflammatory effects. Optical coherence tomography (OCT) is a noninvasive imaging modality with the potential for providing quantitative monitoring of AA response to PRP. Our objective is to share our experience using OCT to monitor the therapeutic progress of patients with AA treated with PRP. Two patients with patchy AA and one with alopecia universalis were treated with PRP three times at 6-week intervals as ...

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    2. NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY

      NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY

      PURPOSE: To precisely quantify retinal nonperfusion areas (NPAs) in branch retinal vein occlusion (BRVO) using widefield optical coherence tomography angiography (OCTA), and examine their association with neovascular complications. METHODS: We enrolled 26 patients with treatment-naïve BRVO and prospectively examined them for 12 months. After three monthly ranibizumab injections to treat macular edema, each patient underwent ultra-wide field (UWF) fluorescein angiography (FA) and OCTA. UWF FA was additionally performed at Month 12. For UWF FA, the retinal NPA was measured using the equipment’s built-in software. For OCTA, we used panoramic image montaged from 5 single 12×12 mm 2 ...

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    3. Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography

      Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography

      Purpose: To compare widefield optical coherence tomography-angiography (OCTA) to ultra-widefield fluorescein angiography (UWFA) in the assessment of nonperfusion in retinal vein occlusion (RVO). Methods: Cross-sectional study of 43 eyes of 43 RVO patients examined using both widefield OCTA (Plexelite, Carl Zeiss Meditec) with a panoramic montage of five 12x12mm images and UWFA (Optos®, 200°). Qualitative analysis was performed according to nonperfusion areas (cutoff: 3 disc areas) on widefield OCTA. The quantitative analysis assessed the vascular density (VD) on the widefield OCTA and ischemic index (ISI) on UWFA. Results: ISI on UWFA and VD in the superficial and deep plexus correlated ...

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    4. Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT

      Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT

      Abstract Purpose : To determine the location of (1) the superior–inferior watershed between the fovea and optic disc (extended raphe) at the peripapillary optical coherence tomography (OCT) measurement circle and (2) the raphe, temporal to the fovea. Methods : We used existing data consisting of 2285 traced retinal nerve fiber bundle trajectories from 83 fundus images. For localization of the extended raphe at the 3.46-mm-diameter OCT measurement circle, trajectories were classified as belonging to the superior or inferior hemiretina, using predefined criteria. For the raphe, we localized the endings of trajectories coming from the superior and inferior arcuate bundles. Results ...

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    5. Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

      Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

      Purpose : The purpose of this study was to investigate the effect of device and scan size on quantitative optical coherence tomography angiography (OCT-A) metrics. Methods : The 3 × 3 mm scans from Optovue AngioVue and Zeiss AngioPlex systems were included for 18 eyes of 18 subjects without ocular pathology. The foveal avascular zone (FAZ) was segmented manually by two observers, from which estimates of FAZ area (using both the nominal image scale and the axial length corrected image scale) and acircularity were derived. Three scan sizes (3 mm, 6 mm HD, and 8 mm) from the AngioVue system were included for ...

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    6. Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System

      Purpose : To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods : Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thickness on OCT scans of the right eye of 10 healthy adults. Three OCT systems were used: handheld Leica Envisu, investigational handheld swept-source OCT (UC3), and Heidelberg Spectralis tabletop system. All eyes were imaged five times with each OCT system by each of two imagers. A components of variance analysis provided estimates of repeatability (variation due to random ...

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    7. Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection

      Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection

      Objectives . To evaluate the internal morphology of blebs using anterior-segment optical coherence tomography (AS-OCT) and the surgical outcomes of Ahmed glaucoma valve (AGV) surgery with Tenon capsule resection compared to conventional AGV surgery in patients with refractory glaucoma. Patients and Methods . This randomised prospective study included 30 eyes from 30 patients (age range: 42–55 y) with refractory glaucoma from March 2018 to February 2020. The study included two groups: AGV with the Tenon capsule resection group ( n  = 15) and the conventional AGV surgery group ( n  = 15). Follow-up continued until 6 months after surgery. The primary outcome was intraocular pressure ...

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    8. Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy

      Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy

      Purpose To describe a case of pregnancy-related central serous chorioretinopathy (pCSCR) and the utility of monitoring with optical coherence tomography (OCT) and OCT angiography (OCTA). Observations A 34-year-old female in her third trimester of pregnancy presented with symptomatic visual disturbances of the right eye. Medical history was otherwise unremarkable. Optical coherence tomography (OCT) disclosed a serous retinal detachment with trace subretinal fibrin and elevation of the retinal pigment epithelium (RPE). OCT angiography (OCTA) demonstrated absence of choroidal neovascular membrane (CNV). It was decided to monitor with weekly OCTs until delivery, after which the patient had full resolution of symptoms and ...

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      Mentions: UCLA
    9. Diagnosis of Coronary Heart Disease by Optical Coherence Tomography Using Random Walk Algorithm

      Diagnosis of Coronary Heart Disease by Optical Coherence Tomography Using Random Walk Algorithm

      Objective : The objective is to study the diagnosis of coronary heart disease by optical coherence tomography based on random walk algorithm, so as to assist doctors in diagnosing coronary heart disease. Method : K -means algorithm combined with mathematical morphology provides seed points for random walk algorithm, and realizes semi-automatic segmentation of different kinds of patches. Secondly, by adding the space distance term based on the distance between the edge and the seed point in the weight function, the random walk algorithm is improved, which can make the weak edge patch area not be segmented too much. Results : the results were ...

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    10. Optical coherence tomography angiography findings in patients with ocular and non-ocular Behcet disease

      Optical coherence tomography angiography findings  in patients with ocular and non-ocular Behcet disease

      Purpose: To describe the optical coherence tomography angiography findings in nonocular Behçet disease . Methods: The superficial capillary plexus (SCP) and deep capillary plexus (DCP) and outer retinal and choroidal flow were evaluated using optical coherence tomography angiography . Perimetry was performed to correlate any microvascular and functional changes. Results: Capillary nonperfusion areas were found in the superficial capillary plexus in 16/20 eyes (80%) and in the DCP in 17/20 eyes (85%). Perifoveal capillary arcade disruption and vessel rarefaction were present in both plexuses in all cases. Capillary telangiectasia was present in the superficial capillary plexus in five eyes ...

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    11. Use of computerized campimetry and/or optical coherence tomography for glaucoma diagnosis by non-glaucoma specialists

      Use of computerized campimetry and/or optical coherence tomography for glaucoma diagnosis  by non-glaucoma specialists

      PURPOSE: To compare the use of visual field and/or optical coherence tomography (OCT) combined with color retinography by non-glaucoma specialists for differentiating glaucoma from physiological cupping. METHODS: Eighty patients with glaucoma or physiological cupping (40 of each) were randomized according to the examination used (GI: color retinography, GII: color retinography + visual field, GIII: color retinography + optical coherence tomography, GIV: color retinography + visual field + optical coherence tomography). Twenty non-specialist ophthalmologists diagnosed glaucoma from PowerPoint slide images, without direct patient examination. RESULTS: Inter-examiner agreement was good for GII (ĸ: 0.63; 95%CI, 0.53-0.72), moderate for GIII (ĸ: 0 ...

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    12. Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction

      Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction

      Purpose of Review To review evidence on the utility of spectral domain optical coherence tomography (SD-OCT) in evaluating retinal structure prior cataract surgery and highlight new technologies that can assess retinal function perioperatively. Recent Findings SD-OCT detected clinically unsuspected macular pathology in 4.6–25% of individuals in the pre-operative cataract evaluation. The most common findings were epiretinal membrane and macular degeneration with frequencies that varied by population studied. These conditions have been associated with complication after surgery (e.g., macular edema, visual dissatisfaction). As such, findings on SD-OCT may impact the informed consent process, alter IOL selection, and provide ...

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    13. Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Significance: The optical properties of biological samples provide information about the structural characteristics of the tissue and any changes arising from pathological conditions. Optical coherence tomography (OCT) has proven to be capable of extracting tissue's optical properties using a model that combines the exponential decay due to tissue scattering and the axial point spread function that arises from the confocal nature of the detection system, particularly for higher numerical aperture (NA) measurements. A weakness in estimating the optical properties is the inter-parameter cross-talk between tissue scattering and the confocal parameters defined by the Rayleigh range and the focus depth ...

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    14. Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

      Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography

      Purpose: To study the subfoveal choroidal thickness (SFCT), macular ganglion cell layer (GCL-IPL) and central macular thickness (CMT) in Caucasian children, and to analyze these optical coherence tomography (OCT) parameters depending on the spherical equivalent (SE). Methods: Cross-sectional study of SFCT, GCL-IPL, and CMT in Caucasian children, analyzed with spectral-domain OCT Cirrus 5000 and Enhanced-depth imaging technique. Correlation between these three OCT parameters, age, sex, and spherical equivalent was analyzed. The eyes were classified into three groups: group 1 included eyes with SE < 0, group 2 included eyes with SE between 0 and +2.00, and group 3 eyes with ...

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    Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography Convolutional neural network-based automatic detection of follicle cells in ovarian tissue using optical coherence tomography Computational adaptive optics in phase-unstable optical coherence tomography Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago Optical imaging techniques could offer non-invasive method to measure swelling within the brain, new study finds Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement Reviewing imaging modalities for the assessment of plaque erosion Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis New technology could improve LASIK surgery, eye disease detection Nondestructive evaluation of fused filament fabrication 3D printed structures using optical coherence tomography Multi-channel swept source optical coherence tomography concept based on photonic integrated circuits
  6. Recent Quotes

    1. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    2. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    3. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    4. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    5. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    6. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    7. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    8. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    9. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    10. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen