1. Feature Of The Week: Stanford University Investigates an Approach of Scalable Multiplexing for Parallel Imaging with Interleaved OCT

    We demonstrate highly parallel imaging with interleaved optical coherence tomography (iOCT) using an in-house-fabricated, air-spaced virtually-imaged phased array (VIPA). The air-spaced VIPA performs spectral encoding of the interferograms from multiple lateral points within a single sweep of the source and allows us to tune and balance several imaging parameters: number of multiplexed points, ranging depth, and sensitivity. In addition to a thorough discussion of the parameters and operating principles of the VIPA, we experimentally demonstrate the effect of different VIPA designs on the multiplexing potential of iOCT. Using a 200-kHz light source, we achieve an effective A-scan rate of 3.2-MHz by multiplexing 16 lateral points onto a single wavelength sweep. The improved sensitivity of this system is demonstrated for 3D imaging of biological samples such as a human finger and a fruit fly.

    For more information see recent Article. Courtesy Hee Yoon Lee and Audrey Ellerbee from Stanford University. To share this article click Here.

    Also see request by Stanford on On Sharing Data and Code in the OCT Community by clicking Here.
  2. Recent Articles From Around The Web

    1. Feature Of The Week 11/23/14: Stanford University Investigates an Approach of Scalable Multiplexing for Parallel Imaging with Interleaved OCT

      Feature Of The Week 11/23/14: Stanford University Investigates an Approach of Scalable Multiplexing for Parallel Imaging with Interleaved OCT

      We demonstrate highly parallel imaging with interleaved optical coherence tomography (iOCT) using an in-house-fabricated, air-spaced virtually-imaged phased array (VIPA). The air-spaced VIPA performs spectral encoding of the interferograms from multiple lateral points within a single sweep of the source and allows us to tune and balance several imaging parameters: number of multiplexed points, ranging depth, and sensitivity. In addition to a thorough discussion of the parameters and operating principles of the VIPA, we experimentally demonstrate the effect of different VIPA designs on the multiplexing potential of iOCT. Using a 200-kHz light source, we achieve an effective A-scan rate of 3 ...

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    2. Is it safe to implant bioresorbable scaffolds in ostial side-branch lesions? Impact of ‘neo-carina’ formation on main-branch flow pattern. Longitudinal clinical observations

      Is it safe to implant bioresorbable scaffolds in ostial side-branch lesions? Impact of ‘neo-carina’ formation on main-branch flow pattern. Longitudinal clinical observations

      Formation of a ‘neo-carina’ has been reported after bioresorbable vascular scaffolds (BVS) implantation over side-branches. However, as this ‘neo-carina’ could protrude into the main-branch, its hemodynamic impact remains unknown. We present two cases of BVS implantation for ostial side-branch lesions, and investigate the flow patterns at follow-up and their potential impact. Computational fluid dynamics analysis was performed, using a 3D mesh created by fusion of 3-dimensional angiogram with optical coherence tomography images. In our first case, mild disturbances were seen when ‘neo-carina’ did not protrude perpendicularly into the main branch. In the second case, extensive flow re-distribution was observed due ...

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    3. SPARSE AND LOW RANK DECOMPOSITION BASED BATCH IMAGE ALIGNMENT FOR SPECKLE REDUCTION OF RETINAL OCT IMAGES

      SPARSE AND LOW RANK DECOMPOSITION BASED BATCH IMAGE ALIGNMENT FOR SPECKLE REDUCTION OF RETINAL OCT IMAGES

      Optical Coherence Tomography (OCT) in an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. Due to the underlying physics, OCT images usually suffer from a granular pattern, called speckle noise, which restricts the process of interpretation. Here, a sparse and low rank decomposition based method is used for speckle reduction in retinal OCT images. In this technique, at first, several OCT images of the same location (to some extent) are acquired and stacked together. The next step is the batch alignment of the images using a sparse and low-rank decomposition based technique ...

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    4. Evaluation of Corneal Stromal Demarcation Line after Two Different Protocols of Accelerated Corneal Collagen Cross-Linking Procedures Using Anterior Segment Optical Coherence Tomography and Confocal Microscopy

      Evaluation of Corneal Stromal Demarcation Line after Two Different Protocols of Accelerated Corneal Collagen Cross-Linking Procedures Using Anterior Segment Optical Coherence Tomography and Confocal Microscopy

      Purpose . To evaluate the depth of corneal stromal demarcation line using AS-OCT and confocal microscopy after two different protocols of accelerated corneal collagen cross-linking procedures (CXL). Methods . Patients with keratoconus were divided into two groups. Peschke CXL device (Peschke CCL-VARIO Meditrade GmbH) applied UVA light with an intended irradiance of 18.0 mW/cm 2 for 5 minutes after applying riboflavin for 20 minutes (group 1) and 30 minutes (group 2). One month postoperatively, corneal stromal demarcation line was measured using AS-OCT and confocal microscopy. Results . This study enrolled 34 eyes of 34 patients (17 eyes in group 1 and ...

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    5. Optical coherence tomography imaging of microfluidic pattern with different refractive index contrast

      Optical coherence tomography imaging of microfluidic pattern with different refractive index contrast

      Optical coherence tomography (OCT) technology is analogous to ultrasound imaging, except that OCT employs light instead of sound. The non-invasive imaging method works by projecting light on test target and detecting the backscattering from the underlying layers. As the OCT technology is based on optical interference, the internal structural features and inhomogeneities induced by different refractive index contrast could be detected and displayed in the form of a gray scale or false color image. In this paper, a typical microfluidic device was produced and measured by a spectral domain OCT instrument. The internal dimensions of the lab-on-chip device were determined ...

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    6. Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking

      Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking

      Purpose . To compare the penetration of riboflavin using a microscope-integrated real time spectral domain optical coherence tomography (ZEISS OPMI LUMERA 700 and ZEISS RESCAN 700) in keratoconus patients undergoing accelerated collagen crosslinking (ACXL) between epithelium on (epi-on) and epithelium off (epi-off). Methods . Intraoperative images were obtained during each of the procedures. Seven keratoconus patients underwent epi-on ACXL and four underwent epi-off ACXL. A software tool was developed using Microsoft.NET and Open Computer Vision (OpenCV) libraries for image analysis. Pre- and postprocedure images were analyzed for changes in the corneal hyperreflectance pattern as a measure of the depth of riboflavin ...

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    7. Simultaneous measurement of localized diffusion and flow using optical coherence tomography

      Simultaneous measurement of localized diffusion and flow using optical coherence tomography

      We report on the simultaneous and localized measurements of the diffusion coefficient and flow velocity based on the normalized autocorrelation function using optical coherence tomography (OCT). Our results on a flowing solution of polystyrene spheres show that the flow velocity and the diffusion coefficient can be reliably estimated in a regime determined by the sample diffusivity, the local flow velocity, and the Gaussian beam waist. We experimentally show that a smaller beam waist results in an improvement of the velocity sensitivity at cost of the precision and accuracy of the estimation of the diffusion coefficient. Further, we show that the ...

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    8. Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Since it was first used to evaluate human genitourinary tissue in 1997, OCT has emerged as a promising modality to provide real-time, high-resolution imaging of urologic organs. In the bladder, it has demonstrated a high sensitivity in identifying regions of the bladder suspicious for CIS and between invasive and noninvasive malignancy; it has been studied as an “optical biopsy” both during the initial cystoscopic diagnosis and intraoperatively in bladder-preserving surgery. Several small, ex vivo studies have shown promising results in the ability of OCT to demonstrate histopathologic alterations to renal morphology such as in renal ischemia and malignancy. It may ...

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    9. Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has to rely on his/her judgement of stage and grade since no tissue is harvested for histological confirmation. In addition, in many centres, patients with a history of low-grade, non-invasive ...

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    10. Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Response of port wine stain (PWS) to photodynamic therapy treatment (PDT) is variable and depends on treatment setting used and anatomic sites as well as on size and depth of ectatic vessels. Optical coherence tomography (OCT) is a non-destructive imaging modality which can reveal the layered structure of the upper part of the skin. The structural features of the PWS skin such as the diameter and depth of the blood vessels in different anatomic sites can be showed in the OCT images. In this study, the possible role of PWS skin structure in the response to PDT is assessed. 82 ...

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    11. Longitudinal Analysis of Reticular Drusen Associated with Age-Related Macular Degeneration Using Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging

      Longitudinal Analysis of Reticular Drusen Associated with Age-Related Macular Degeneration Using Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging

      Purpose: To evaluate longitudinal variations of reticular drusen (RDR) in age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO), near-infrared reflectance (NIR) and spectral-domain optical coherence tomography (SD-OCT) imaging. Methods: Eighteen eyes of 12 patients with RDR (median observational time 5 months, range 3-10) were included. Changes over time in the en face cSLO NIR images, the identical SD-OCT B scan (simple approach) and the dense SD-OCT volume scans (11 µm between B scans, detailed approach) for 5 preselected RDR lesions were analysed, respectively. Results: Nineteen of 90 (21%) lesions were no longer detectable at the follow-up examination with the ...

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    12. Additive Diagnostic Role of Imaging in Glaucoma: Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography

      Additive Diagnostic Role of Imaging in Glaucoma: Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography

      Purpose: To investigate the additive diagnostic role of spectral-domain optical coherence tomography (SD-OCT) and red-free retinal nerve fiber layer photography (RNFLP) in making clinical glaucoma diagnosis. Methods: Four diagnostic combination sets, including the most recent image from each measurement of 196 glaucoma eyes (including the 44 preperimetric glaucoma eyes) and 101 healthy eyes, were prepared: (1) stereo disc photography and Humphrey visual field (SH); (2) SH and SD-OCT (SHO); (3) SH and RNFLP (SHR); 4) SHR and SD-OCT (SHRO). Each randomly sorted set was serially presented at one-month intervals to five glaucoma specialists who were asked to evaluate them in ...

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    13. Optical Coherence Tomography Study of Retinal Changes in Normal Aging and after Ischemia

      Optical Coherence Tomography Study of Retinal Changes in Normal Aging and after Ischemia

      Purpose. Age-related thinning of the retinal ganglion cell axons in the nerve fiber layer has been measured in humans using optical coherence tomography (OCT). In this study, we used OCT to measure inner retinal changes in 3-months-, one-year, and two-year-old mice and after experimental anterior ischemic optic neuropathy (AION). Methods. We used OCT to quantify retinal thickness in over 200 eyes at different ages before and after photochemical thrombosis model of AION. The scans were manually or automatically segmented. Results. In normal aging, there was 1.3 µm thinning of the ganglion cell complex (GCC) between 3-months and 1-year (P ...

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    14. Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Photodynamic therapy (PDT) has become a promising alternative for treatment of skin lesions such as squamous cell carcinoma. We propose a method to monitor the effects of PDT in a noninvasive way by using the optical attenuation coefficient (OAC) calculated from optical coherence tomography (OCT) images. We conducted a study on mice with chemically induced neoplastic lesions and performed PDT on these lesions using homemade photosensitizers. The response of neoplastic lesions to therapy was monitored using, at the same time, macroscopic clinical visualization, histopathological analysis, OCT imaging, and OCT-based attenuation coefficient measurement. Results with all four modalities demonstrated a positive ...

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      Mentions: Anne Latrive
    15. Monitoring of strain-dependent responsiveness to TLR activation in the mouse anterior segment using SD-OCT

      Monitoring of strain-dependent responsiveness to TLR activation in the mouse anterior segment using SD-OCT

      Purpose: To determine whether spectral-domain optical coherence tomography (SD-OCT) can be used to longitudinally monitor inflammation in the mouse anterior segment and to identify any strain-dependent differences in responsiveness to distinct toll-like receptor ligands. Methods: Corneal inflammation was induced in BALB/c and C57BL/6 mice following central corneal abrasions and topical application of saline, toll-like receptor (TLR)-4 ligand, lipopolysaccharide (LPS) or TLR9 ligand, CpG-ODN (CpG). Anterior-segment images were captured using SD-OCT at baseline, 24 hours and one-week post-treatment. Corneal thickness, stromal haze and the number of keratic precipitates (KP) and anterior chamber (AC) cells were longitudinally compared to ...

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    Leading Irish University Bio-Photonics Laboratory And Compact Imaging Extend Agreement For Innovative Research Collaboration Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill Depth-encoded all-fiber swept source polarization sensitive OCT Optical coherence elastography for tissue characterization: a review Monte Carlo modeling of angiographic optical coherence tomography Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography Macrophages and intravascular optical coherence tomography bright spots: a quantitative study Optical coherence tomography in the 2um wavelength regime for paint and other high opacity materials
  7. Recent Quotes

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      By Martin J. Leahy
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