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• Feature Of The Week: 6/28/09: Fully Automatic Three-Dimensional (3D) Quantitative Analysis of Intracoronary Optical Coherence Tomography: Method and Validation 
• Recent developments in Fourier Domain Mode Locked lasers for optical coherence tomography: Imaging at 1310 nm vs. 1550 nm wavelength 
• Towards freehand image acquisition in optical coherence tomography 
• Refractive Surgery: Advanced optical coherence tomography an integral diagnostic tool 
• The Supercontinuum Laser Source: Fundamentals with Updated References 
• Light source for swept source optical coherence tomography based on cascaded distributed feedback lasers with engineered band gaps 
• BS/MS Research Associate - Ocular Imaging at Novartis 
• Imaging pharmaceutical tablets with optical coherence tomography 
• An investigation of the accelerated thermal degradation of different epoxy resin composites using x-ray micro computed tomography and optical coherence tomography 
• Spectral domain phase microscopy (sdpm) dual mode imaging systems and related methods and computer program products 

Feature Of The Week

Featured Articles

1. How to improve the effectiveness of transurethral resection in nonmuscle invasive bladder cancer?

   Explore Article LWW Online (1 hour, 26 min ago) Oncology , Urology

   Purpose of review: The high rate of early recurrences in nonmuscle invasive bladder cancer is considered to be strongly related to the effectiveness of transurethral resection (TUR). The aim of this article is to review methods, currently available or in development, that aim at improving TUR, with an emphasis on studies over the past year. Recent findings: It has been shown that re-TUR diminishes staging error and improves local tumour control. However, instead of simply ... (Read Full Article)
   

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2. Accuracy of Retinal Thickness Measurements obtained with Cirrus Optical Coherence Tomography

   Explore Article BJO Online (Jul 2 2009) Ophthalmology

   Aim: To report the frequency and severity of retinal thickness measurement errors in a Fourier domain optical coherence tomography (FDOCT) device, Cirrus OCT. Methods: Data from 209 eyes undergoing Cirrus OCT imaging with the Macular Cube protocol were collected. For each eye, the position of the automated retinal boundary lines used by the Cirrus OCT software for thickness calculations was assessed using a 6-point categorical scale. The presence of errors was correlated with various parameters ... (Read Full Article)
   

   Comment on Article Mentions:   Alexander C. Walsh   Keck School of Medicine   David Geffen School of Medicine

3. Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography

   Explore Article www3.interscience.wiley.com (Jul 2 2009) Ophthalmology

   A single case of multifocal choroiditis with panuveitis (MFCPU) was investigated by a three-dimensional (3-D) high-penetration optical coherence tomography. The HP-OCT is based on a swept-source OCT technology, uses a probe beam with a center wavelength of 1060 nm, and possesses a depth resolution of 10.4 [mu] min tissue. Two eyes of an MFCPU patient were involved in this study. The eyes were also examined by color fundus photograph, fluorescein angiography (FA), and indocyanine green ... (Read Full Article)
   

   Comment on Article Mentions:   Yoshiaki Yasuno   University of Tsukuba

4. OCT-assisted control of catheter positioning in the urethra of the rabbit — A feasibility study

   Explore Article ScienceDirect (Jul 1 2009) Urology

   Background A fundamental precondition of local radiotherapy by means of 32P-loaded urethral catheters is a precise position with respect to the target tissue. This feasibility study investigates optical coherence tomography (OCT)-assisted examination of the catheter position and its adherence to the tissue surface. Materials and methods OCT investigations were performed using an animal model (rabbit urethra, n=4). A radial scanning OCT probe located in the lumen of the catheter provided OCT images of the catheter ... (Read Full Article)
   

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5. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

   Explore Article European Respiratory Journal (Jul 1 2009) Bronchoscopy , Otolaryngology

   The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment. Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and ... (Read Full Article)
   

   Comment on Article Mentions:   David D. Sampson   University of Western Australia   Sir Charles Gairdner Hospital

6. Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin

   Explore Article SPIE Digital Library (Jul 1 2009) Dentistry

   Previous studies have demonstrated that polarization-sensitive optical coherence tomography (PS-OCT) can be used to image caries lesions in dentin, measure nondestructively the severity of dentin demineralization, and determine the efficacy of intervention with anticaries agents including fluoride a ... [J. Biomed. Opt. 14, 044002 (2009)] published Wed Jul 1, 2009. (Read Full Article)
   

   Comment on Article Mentions:   Daniel S. Fried   Cynthia L. Darling   UCSF

7. Comparison of Three Different Optical Coherence Tomography Models for Total Macular Thickness Measurements in Healthy Controls

   Explore Article index (Jul 1 2009) Ophthalmology

   Background/Aims: Conventional time domain optical coherence tomography (OCT) has become an important diagnostic tool to measure retinal thickness in clinical routine. Recently, different models of high-speed, high-resolution frequency domain OCTs have been introduced by various manufacturers. The purpose of this study was to compare 3 commercially available OCT models for retinal thickness measurements in healthy controls. Methods: OCT scans were performed on 28 healthy eyes with the RTVue-100 FD-OCT (Optovue Inc., USA), the Cirrus HD-OCT ... (Read Full Article)
   

   Comment on Article Mentions:   Optovue   Zeiss Stratus OCT   Optovue RTVue-100

8. NIR confocal microscopy for painting diagnostics

   Explore Article SPIE Digital Library (Jul 1 2009) Art , Microscopy

   We designed and built a simple fiber-optic confocal laser-scanning interference microscope, operating in the near infrared (NIR), for the analysis of paintings. We applied this instrument to the non-invasive optical sectioning of the paint layers. The device was tested on both laboratory samples and ancient paintings. The preliminary results show that optical sections obtained by NIR confocal microscopy are comparable to those recorded with well known optical coherence tomography and a few examples of application ... (Read Full Article)
   

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9. Towards freehand image acquisition in optical coherence tomography

   Explore Article Home: SPIE.org (Jun 30 2009) Probes

   A new data-capture method could provide increased flexibility for clinical imaging applications. Optical coherence tomography (OCT), a biomedical diagnostic-imaging technique, is currently transitioning from the research laboratory into clinical practice.1 Providing micrometer-scale resolution over millimeter-scale fields of view, OCT is the optical analog of ultrasound. It uses low-coherence interferometry to perform optical ranging in biological tissue. Clinical applications under investigation include optical biopsy2 and detection of tumor margins during image-guided surgery.3 The clinical applications of ... (Read Full Article)
   

   Comment on Article Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Eric J. Chaney

10. Optical coherence tomography and Raman spectroscopy of the ex-vivo retina

    Explore Article www3.interscience.wiley.com (Jun 30 2009) Ophthalmology

    Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo ... (Read Full Article)
    

    Comment on Article Mentions:   John S. Werner   UC Davis   Robert J. Zawadzki

11. Recent developments in Fourier Domain Mode Locked lasers for optical coherence tomography: Imaging at 1310 nm vs. 1550 nm wavelength

    Explore Article www3.interscience.wiley.com (Jun 29 2009) Tunable Sources

    We report on recent progress in Fourier domain mode-locking (FDML) technology. The paper focuses on developments beyond pushing the speed of these laser sources. After an overview of improvements to FDML over the last three years, a brief analysis of OCT imaging using FDML lasers with different wavelengths is presented. For the first time, high speed, high quality FDML imaging at 1550 nm is presented and compared to a system at 1310 nm. The imaging ... (Read Full Article)
    

    Comment on Article Mentions:   Robert Huber   Ludwig Maximilian University of Munich

12. An investigation of the accelerated thermal degradation of different epoxy resin composites using x-ray micro computed tomography and optical coherence tomography

    Explore Article ScienceDirect (Jun 27 2009) NDE/NDT

    Epoxy resin composites reinforced with hollow glass microspheres, microlight microspheres, 3D parabeam glass, and E-Glass individually were subjected to accelerated thermal degradation conditions. X-ray micro computed tomography (XμCT) was used to evaluate density changes, reinforcement filler damage, homogeneity, cracks and microcracks in the bulk of the different epoxy resin composites. XμCT 3D images, 2D reconstructed images and voids calculations revealed microspheres damage, filler distributions and showed cracks in all composites with different shapes and volume ... (Read Full Article)
    

    Comment on Article Mentions:   Upper Austrian Research GmbH   David Stifter   Karin Wiesauer

13. Automated algorithm for breast tissue differentiation in optical coherence tomography

    Explore Article SPIE Digital Library (Jun 26 2009) Oncology

    An automated algorithm for differentiating breast tissue types based on optical coherence tomography (OCT) data is presented. Eight parameters are derived from the OCT reflectivity profiles and their means and covariance matrices are calculated for each tissue type from a training set (48 samples) selected based on histological examination. A quadratic discrimination score is then used to assess the samples from a validation set. The algorithm results for a set of 89 breast tissue samples ... (Read Full Article)
    

    Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated

14. Development of Microelectrode Arrays for Artificial Retinal Implants using Liquid Crystal Polymers

    Explore Article iovs.org (Jun 26 2009) Ophthalmology

    Purpose: To develop a liquid crystal polymer (LCP) based, long-term implantable, retinal stimulation microelectrode array using a novel fabrication method. Methods: The fabrication process used laser micromachining and customized thermal-press bonding to produce LCP based microelectrode arrays. To evaluate the fabrication process and the resulting electrode arrays, in vitro reliability tests and in vivo animal experiments were performed. The in vitro tests consisted of electrode site impedance recording and electrode inter-layer adhesion monitoring during accelerated ... (Read Full Article)
    

    Comment on Article Mentions:   Sang-Won Lee   Seoul National University

15. Multimodality bonchoscopic imaging of tracheopathica osteochondroplastica

    Explore Article SPIE Digital Library (Jun 25 2009) Bronchoscopy

    Results of a commercial optical coherence tomography system used as part of a multimodality diagnostic bronchoscopy platform are presented for a 61-year-old patient with central airway obstruction from tracheopathica osteochondroplastica. Comparison to results of white-light bronchoscopy, histology, ... [J. Biomed. Opt. 14, 034035 (2009)] published Thu Jun 25, 2009. (Read Full Article)
    

    Comment on Article Mentions:   Imalux   UC Irvine   Imalux Niris

16. Automated segmentation of tissue structures in optical coherence tomography data

    Explore Article SPIE Digital Library (Jun 25 2009)

    Segmentation of optical coherence tomography (OCT) images provides useful information, especially in medical imaging applications. Because OCT images are subject to speckle noise, the identification of structures is complicated. Addressing this issue, two methods for the automated segmentation of arbitrary structures in OCT images are proposed. The methods perform a seeded region growing, applying a model-based analysis of OCT A-scans for the seed's acquisition. The segmentation therefore avoids any user-intervention dependency. The first region-growing algorithm ... (Read Full Article)
    

    Comment on Article Mentions:   University of Lübeck

17. OCT imaging of skin cancer and other dermatological diseases

    Explore Article www3.interscience.wiley.com (Jun 25 2009) Dermatology , Oncology

    Optical coherence tomography (OCT) provides clinicians and researchers with micrometer-resolution, in vivo, cross-sectional images of human skin up to several millimeter depth. This review of OCT imaging applied within dermatology covers the application of OCT to normal skin, and reports on a large number of applications in the fields of non-melanoma skin cancer, malignant melanomas, psoriasis and dermatitis, infestations, bullous skin diseases, tattoos, nails, haemangiomas, and other skin diseases (Read Full Article)
    

    Comment on Article Mentions:   Peter E. Andersen   Thomas M. Jørgensen   Technical University of Denmark

18. CEOs Look for Bright Spots

    Explore Article Photonics.com (Jun 24 2009) Other Business News

    While some optical technology areas are experiencing high growth rates, that growth may be limited by the number of qualified workers available, and innovations are still needed in the production process. Those were a few of the conclusions reached during the CEO round table, "Optical Technologies – Bright Hopes in Times of Crisis," held during Laser World of Photonics 2009. (Read Full Article)
    

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19. In vivo confocal microscopy of the ocular surface: where are we now?

    Explore Article BJO Online (Jun 23 2009) Microscopy , Ophthalmology

    Until recent times, the universally diffused diagnostic tool for the imaging of the cornea and ocular surface had been based on traditional slit-lamp biomicroscopy, with or without the aid of stains. The exponential technological evolution that occurred during the last two decades has led to the introduction of new instruments such as corneal topography, ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT) for the analysis of the anterior segment. These techniques provide details on corneal ... (Read Full Article)
    

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20. Speckle reduction in optical coherence tomography using angular compounding by B-scan Doppler-shift encoding

    Explore Article SPIE Digital Library (Jun 23 2009) Doppler

    We propose a novel method for speckle reduction for optical coherence tomography based on angular compounding by B-scan Doppler-shift encoding (AngularCBD). By decentering the probe beam from the pivot of a scanning mirror, the illumination angle represented by different components of the beam can be encoded in Doppler shift. Compounding multiple images reconstructed from different Doppler-shift bands, we can suppress speckle without sacrificing image acquisition speed. Speckle reduction with AngularCBD is demonstrated by imaging a ... (Read Full Article)
    

    Comment on Article Mentions:   Case Western Reserve University   Andrew M. Rollins

21. See all articles

Recent Articles From Around The Web

1. Edema of the Photoreceptor Layer in Vogt-Koyanagi-Harada Disease Observed Using High-Resolution Optical Coherence Tomography

   Explore Article 대한안과학회 (1 hour, 1 minute ago) Ophthalmology

   Purpose: To evaluate the characteristics of fluid accumulation in the uveitic stage of Vogt-Koyanagi-Harada (VKH) disease using high resolution optical coherence tomography (OCT3). Methods: Twenty-eight eyes in 14 patients with VKH disease were reviewed retrospectively. These 28 eyes were divided into 19 eyes with intraretinal fluid (C group) and 9 eyes without intraretinal fluid (N group). Changes in visual acuity and fluid accumulation observed using OCT were compared between the two groups. Results: Visual acuity ... (Read Full Article)
   

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2. Refractive Prescription Using Optical Coherence Tomography (Wo 2009/080331)

   Explore Article wipo.int (Jul 2 2009) Ophthalmology , Patents

   An optical coherence tomography apparatus and method for measuring refractive power of the human cornea is disclosed. The apparatus collects both the specularly reflected light from the anterior surface of the cornea and diffusely reflected light from the interior of the cornea. The combined refractive power of both surfaces of the cornea is determined. (Read Full Article)
   

   Comment on Article Mentions:   Scott A. Meyer   Carl Zeiss Meditec

3. Fundus Autofluorescence in Type 2 Idiopathic Macular Telangiectasia: Correlation with Optical Coherence Tomography and Microperimetry

   Explore Article American Journal of Ophthalmology (Jul 1 2009) Ophthalmology

   Purpose: To use multiple imaging methods to investigate patients with type 2 idiopathic macular telangiectasia (IMT) at different disease severity stages so as to characterize and categorize disease progression through the full spectrum of disease phenotypes.Design: Observational case series.Methods: Twelve patients with type 2 IMT (22 eyes) examined with fundus photography, angiography, optical coherence tomography imaging, fundus autofluorescence (FAF), and microperimetry testing in an institutional setting.Results: Eyes examined by multiple imaging methods were classified into ... (Read Full Article)
   

   Comment on Article Mentions:   National Eye Institute

4. Spectral domain phase microscopy (sdpm) dual mode imaging systems and related methods and computer program products

   Explore Article PatFT » Page 1 of 1 (Jun 30 2009) Patents

   Some embodiments of the present invention provide optical coherence tomography systems including an OCT engine and a processor. The OCT engine is configured to provide both standard OCT imaging and spectral domain phase microscopy (SDPM) imaging. The processor is coupled to the OCT engine and is configured to use a first signal processing method when the OCT engine is configured to provide standard OCT imaging and a second signal processing method when the OCT engine ... (Read Full Article)
   

   Comment on Article Mentions:   Joseph A. Izatt   Eric L. Buckland   Bioptigen

5. Light source for swept source optical coherence tomography based on cascaded distributed feedback lasers with engineered band gaps

   Explore Article PatFT » Page 1 of 1 (Jun 30 2009) Patents , Tunable Sources

   The present invention is a tunable semiconductor laser for swept source optical coherence tomography, comprising a semiconductor substrate; a waveguide on top of said substrate with multiple sections of different band gap engineered multiple quantum wells (MQWs); a multiple of distributed feedback (DFB) gratings corresponding to each said band gap engineered MWQs, each DFB having a different Bragg grating period; and anti-reflection (AR) coating deposited on at least the laser emission facet of the laser ... (Read Full Article)
   

   Comment on Article Mentions:   Carl Zeiss Meditec

6. Device for treating vulnerable plaque

   Explore Article PatFT » Page 1 of 1 (Jun 30 2009) Cardiology , Patents

   A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly ... (Read Full Article)
   

   Comment on Article Mentions:   Advanced Cardiovascular Systems

7. Macular and Nerve Fiber Layer Thickness in Amblyopia: The Sydney Childhood Eye Study

   Explore Article OphSource (Jun 28 2009) Ophthalmology

   Purpose: To examine macular and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopia.Design: Population-based cross-sectional study.Participants: Of 4118 children examined in the Sydney Childhood Eye Study (incorporating the Sydney Myopia Study) from 34 randomly selected primary schools and 21 secondary schools from 2003 to 2005, 3529 (85.7%) were included in this analysis. The median age of the 2 samples was 6 years (n = 1395) and 12 years (n = 2134), respectively.Methods: A detailed ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec   Paul Mitchell

8. Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis

   Explore Article Neurology (Jun 28 2009) Ophthalmology

   Objectives: Determine the utility of optical coherence tomography (OCT) to detect clinical and subclinical remote optic neuritis (ON), its relationship to clinical characteristics of ON and visual function, and whether the retinal nerve fiber layer (RNFL) thickness functions as a surrogate marker of global disease severity. Methods: Cross-sectional study of 65 subjects with at least 1 clinical ON episode at least 6 months prior. Measures included clinical characteristics, visual acuity (VA), contrast sensitivity (CS), OCT, ... (Read Full Article)
   

   Comment on Article Mentions:   Washington University in St. Louis

9. Feature Of The Week: 6/28/09: Fully Automatic Three-Dimensional (3D) Quantitative Analysis of Intracoronary Optical Coherence Tomography: Method and Validation

   Explore Article Optical Coherence Tomography News (Jun 27 2009) Cardiology

   Feature Of The Week: 6/26/09: Optical Coherence Tomography continues to make tremendous progress in the diagnosis and treatment of coronary artery disease and second generation systems have accelerated that progress. The Thoraxcenter has been a leading organizations in this field as can be seen by clicking the Cardiology t (Read Full Article)
   

   Comment on Article Mentions:   Thoraxcenter at Erasmus University Medical Center   Nico Bruining   LightLab Imaging

10. BS/MS Research Associate - Ocular Imaging at Novartis

    Explore Article CareerBuilder.com Jobs (Jun 27 2009) Jobs & Studentships

    We are seeking a highly motivated scientist with experience in ocular imaging technologies or electrophysiology to join the Ophthalmology Pharmacology group of the Novartis Institutes for Biomedical Research (NIBR) in Cambridge, MA. Primary responsibilities will include animal model characterization employing techniques such as ERG, optical coherence tomography (OCT), scanning laser ophthalmoscopy (SLO) and confocal microscopy.The ideal candidate will have a B.S. or M.S. in Biophysics, Biomedical Engineering, Physiology, Vision Science, Pharmacology, or a related field ... (Read Full Article)
    

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11. Refractive Surgery: Advanced optical coherence tomography an integral diagnostic tool

    Explore Article Modern Medicine (Jun 27 2009) Ophthalmology

    Retinal optical coherence tomography (OCT) is on its way to becoming the next "must-have" tool for preoperative examination of refractive surgery candidates. Spectral-domain OCT (SD-OCT) devices, such as a particular device (3D-OCT, Topcon Medical Systems), enable clinicians to see anatomic features and abnormalities that cannot be visualized with other routine screening technologies, said Daniel S. Durrie, MD, a refractive surgeon in Overland Park, KS (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Daniel S. Durrie

12. Datasheet: SU-LDH Digital Line Scan Camera

    Explore Article Photonics Online (Jun 27 2009) Other Business News

    The new SU-LDH-1.7 Linear Digital High speed InGaAs Camera increases line rates for 1024 pixels to over 46,000 lines per second for spectral-domain optical coherence tomography (SD-OCT), NIR spectroscopy and machine vision. This versatile high speed camera provides 14-bit digital capture into base format Camera Link® interface cards. It utilizes the new LC series of linear arrays, which feature double-sampling, integrate-whileread acquisition and low noise, delivering the high dynamic range demanded by these applications. The ... (Read Full Article)
    

    Comment on Article Mentions:   Sensors Unlimited

13. The Supercontinuum Laser Source: Fundamentals with Updated References

    Explore Article Springer US (Jun 27 2009) Broadband Sources , Textbooks

    Photonics and nonlinear optics are important areas of science, engineering and technology. One of the most important ultrafast nonlinear optical processes is the supercontinuum (SC) – the production of intense white light pulses covering: uv, visible, NIR, MIR, and IR. It is produced using ultrashort laser pulses (ps/fs) to produce the ultrabroad band of frequencies. This book covers the fundamental principles and surveys research of current thinkers and experts in the field with updated references ... (Read Full Article)
    

    Comment on Article Mentions:   City University of New York   Robert R. Alfano

14. Repeatability and Reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography

    Explore Article bentham.org (Jun 26 2009) Ophthalmology

    Aim: To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by ... (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Topcon OCT-1000

15. Interobserver agreement for the detection of optical coherence tomography features of neovascular age-related macular degeneration

    Explore Article iovs.org (Jun 26 2009) Ophthalmology

    Purpose. To investigate the inter-observer agreement for the detection of optical coherence tomography (OCT) features of disease activity in patients with neovascular age-related macular degeneration (nAMD). Method. A cross-sectional agreement study with grading of OCT line scans from patients with nAMD prior to receiving treatment conducted by 2 retinal specialists. Scans were graded for the presence of features of nAMD disease activity (intra-retinal cysts, IRC; subretinal fluid, SRF; diffuse retinal edema, DRE; retinal pigment epithelial ... (Read Full Article)
    

    Comment on Article Mentions:   Adnan Tufail   Praveen J. Patel

16. See all articles