1. Featured Articles

    1. En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      Explore Wiley Online Library Urology
      En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit) were compared for different tissue types, annotated on the histology slides. To avoid misclassification, the poor‐quality slides, and edges of annotations were excluded. Accurate registration of OCT data with ...

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      Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen

    2. Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Conavi Medical Inc. and Japan Lifeline are pleased to announce that they have received regulatory approval from the Ministry of Health, Labor and Welfare (MHLW) in Japan for the Novasight Hybrid TM intravascular imaging system. The Novasight Hybrid system is the world’s first clinical system capable of providing both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on a single imaging catheter. The system also has Health Canada approval and FDA 510(k) clearance in the USA. Japan Lifeline is the exclusive distributor for this technology in Japan. Dr. Brian Courtney, Conavi Medical’s Chief Executive Officer, comments that ...

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      Mentions: FDA Brian K. Courtney Conavi Medical Inc.

    3. Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Explore OSA | OSA Publishing NDE/NDT
      Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Silicon carbide (SiC) is widely used in high power electronic devices. However, defects on the SiC significantly reduce the yield and decrease the performance of SiC. Accurate detection of the defects is essential in the process control. We demonstrated a noninvasive three-dimensional (3D) defect detection method for SiC using optical coherence tomography (OCT). Defects including the triangular defects, hexagonal voids, grain boundaries, and carrot defects were inspected and analyzed on SiC wafers. The 3D images of defects acquired with OCT provided detailed information on the 3D structures and dimensions of defects, and the locations and orientations of the defects inside ...

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      Mentions: Pei Ma

    4. Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      A PostDoc position is available from March 1, 2020 at the Center for Medical Physics and Biomedical Engineering, Medical University of Vienna. We offer a research position in the field of biomedical imaging with strong interdisciplinary collaboration. Our research group is developing novel coherent biomedical imaging methods based on parallel OCT and digital adaptive optics to overcome the conventional resolution limits and to pave the way from pure structural to functional tissue and cell metabolic imaging. This involves profound knowledge of theoretical and experimental optics, system engineering, data and image processing, as well as hands-on experience in modern biomedical optics ...

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      Mentions: Rainer A. Leitgeb Medical University of Vienna

    5. Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Explore Wiley Online Library Developmental Biology
      Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Noninvasive visualization of embryos at different development stages is crucial for the understanding of the basic developmental biology. It is therefore desirable to have an imaging tool capable of rapidly evaluating the effects of gene manipulation or genome editing in developing embryos for the studies of gene functions and genetic engineering. Here, we propose and demonstrate a novel use of optical coherence tomography (OCT) to noninvasively exam the embryonic development of the migratory locusts in real time with 3‐dimensional (3D) view capability. In particular, we obtain the sufficiently high spatial resolution tomographic 2D and 3D images of live locust ...

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    6. Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Explore OSA | OSA Publishing Dermatology
      Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo . This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of ∼ 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal ...

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      Mentions: Arnaud Dubois Damae Medical

    7. Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Explore Wiley Online Library Ophthalmology
      Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Objective Optical coherence tomography (OCT) measurement of adult blue‐fronted parrots ( Amazona aestiva ), free from infectious, inflammatory or neoplastic systemic diseases and from any ophthalmological illness, aim at its characterization, as well as to standardize the examination technique for the species. Procedure Pupillary dilation was achieved with rocuronium bromide (5 mg/mL) at 0, 2, 15, 17, 30, and 32 minutes. The animals were sedated with midazolam maleate (0.5 mg/kg/IM) and anesthetized with propofol (5.0 mg/kg/IV). Measurements were made to evaluate the thickness of the total retina (TR), sensorineural retinal (SR), and ganglion cell ...

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    8. Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      Explore MDPI Open Access Journals Platform Tunable Sources
      Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      In this study, we present a swept source that can intelligently control its sweeping speed while satisfying the commercial stability and miniaturization standards. The source’s central wavelength of the output spectrum is 1300 nm and spectral width is greater than 100 nm. Meanwhile, the scan frequency can be adjusted to range from 20 to 100 kHz, and the stability degree of the optical capacity is less than 0.34%. Additionally, this study establishes a numerical model for the swept-source optical coherence tomography (SS–OCT) system and introduces a numerical simulation of the signal produced during the OCT imaging process ...

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    9. OCT Cost Effective, Useful Pre-Cataract Surgery

      Explore reviewofoptometry.com Ophthalmology
      OCT Cost Effective, Useful Pre-Cataract Surgery

      An estimated 64.4% of patients were willing to pay for the extra imaging step. For patients considering cataract surgery with a multifocal intraocular lens (IOL), optical coherence tomography (OCT) done prior to the procedure may increase the overall cost, but it also could be beneficial in detecting other macular pathologies and improving quality of life, a study in Ophthalmology reports. Based on their analysis, researchers found approximately 20.5% of patients undergoing cataract surgery may have macular pathologies, of which 11% may not be found during the initial clinical exam. The investigation’s base case was a 67-year-old male ...

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    10. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Explore LWW Online Gynecology
      Optical Vaginal Biopsy Using Optical Coherence Tomography

      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...

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      Mentions: Zhongping Chen UC Irvine Yan Li

    11. Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Explore ScienceDirect
      Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Intravital microscopy (IVM) and optical coherency tomography (OCT) are two powerful optical imaging tools that allow visualization of dynamic biological activities in living subjects with subcellular resolutions. Recent advances in labeling and label-free techniques empower IVM and OCT for a wide range of preclinical and clinical cancer imaging, providing profound insights into the complex physiological, cellular, and molecular behaviors of tumors. Preclinical IVM and OCT have elucidated many otherwise inscrutable aspects of cancer biology, while clinical applications of IVM and OCT are revolutionizing cancer diagnosis and therapies. We review important progress in the fields of IVM and OCT for cancer ...

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      Mentions: Stanford University Michigan State University Adam de la Zerda

    12. Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Explore ACS Publications Home Page
      Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Optical coherence tomography (OCT) has gained wide adoption in biological research and medical imaging due to its exceptional tissue penetration, 3D imaging speed and rich contrast. However, OCT plays a relatively small role in molecular and cellular imaging due to the lack of suitable biomolecular contrast agents. In particular, while the green fluorescent protein has provided revolutionary capabilities to fluorescence microscopy by connecting it to cellular functions such as gene expression, no equivalent reporter gene is currently available for OCT. Here we introduce gas vesicles, a class of naturally evolved gas-filled protein nanostructures, as genetically encodable OCT contrast agents. The ...

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      Mentions: California Institute of Technology UCSD OCT Medical Imaging Inc

    13. PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      Explore Optical Coherence Tomography News Otolaryngology , Other Business News
      PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced the company’s TOMi ™ Scope was awarded best healthcare product at the 12th Annual Prism Awards in San Francisco. The Prism Awards is an annual international competition that honors the best new optics and photonics products on the market. Since 2008, SPIE, along with media partner Photonics Media, has presented awards to companies and individuals that are creating products that make a difference, solve problems, and improve life through photonics. The Prism Awards reflect the exponential growth, exciting developments, and rich technical innovations ...

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      Mentions: Stephen A. Boppart FDA Ryan L. Shelton

    14. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Explore Nature Publishing Group Ophthalmology
      Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity associated findings collectively define the “Spaceflight Associated Neuro-ocular Syndrome” (SANS). We compare and contrast prior published work on SANS by the National Aeronautics and Space Administration’s (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. In this manuscript, we update and review the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). We ...

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      Mentions: Carl Zeiss Meditec

    15. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Explore RSC Publishing Home Urology
      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...

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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Peter E. Andersen

    16. Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for quantitative analysis of OCT/OCTA and machine learning based image classification. This position will be supported by a NIH project entitled differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy . The successful candidate should have a Ph.D. degree in ...

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      Mentions: National Institutes of Health Xincheng Yao

    17. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Explore American Physiological Society Journal Pulmonology
      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b -transgenic mice with ...

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      Mentions: Gereon Hüttmann University of Lübeck

    18. Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Inc. (“Acucela”), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), announced today that the company was invited to meet with NASA and the Translational Research Institute for Space Health (TRISH) *1 to present on January 30, 2020 the status of its Swept Source-OCT *2 (“SS-OCT”) device being developed for NASA’s Deep Space missions. The purpose of the meeting was to review and discuss progress of this Phase 1 project with the engineers, basic and medical scientists and program managers from NASA and TRISH. Additionally, a demonstration of the Phase 1 device ...

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      Mentions: Massachusetts Institute of Technology California Institute of Technology Baylor College of Medicine

    19. New OCT Image Analysis Capabilities From Wasatch Photonics

      Explore Optical Coherence Tomography News Other Business News
      New OCT Image Analysis Capabilities From Wasatch Photonics

      Wasatch Photonics is pleased to announce the expansion of our WP OCT Software and software development kits with new features to facilitate the translation of images into actionable information. These OCT image analysis capabilities lower the barrier to use for OCT by non-experts, and offer the potential for automated analysis of images in real time. The new features include image enhancement, layer segmentation, and classification functions based on powerful machine learning algorithms, and may be accessed from our user-friendly OCT image acquisition software or via our software development kits (SDKs). To help you see the possibilities, we have trained our ...

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      Mentions: Wasatch Photonics
    20. See all articles

  2. Recent Articles From Around The Web

    1. ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      Explore BJO Online Ophthalmology
      ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      Background/aims The prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD). Methods 2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres (RCs) regarding signs of choroidal neovascularisation (CNV) activity, including presence of intraretinal fluid, subretinal fluid, and/or increase in pigment epithelial detachments. Agreement between clinicians and RCs was calculated. Treatment ...

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      Mentions: University of Cologne University of Tübingen Frank G. Holz

    2. Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I

      Explore SAGE Journals Ophthalmology
      Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I

      Purpose: The purpose of the present study was to compare visual function assessment, visual evoked potential, and optical coherence tomography with measurement of retinal nerve fiber layer thickness for the diagnosis of optic pathway glioma in children with neurofibromatosis type 1. Methods: This retrospective observational study included patients with neurofibromatosis type 1 who underwent brain magnetic resonance imaging scan, visual evoked potential study, and peripapillary retinal nerve fiber layer evaluation by optical coherence tomography. Patients were tested with pattern-reversal visual evoked potential and with flash visual evoked potential in case of poor cooperation. Optical coherence tomography was performed with HRA ...

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      Mentions: Heidelberg Engineering Heidelberg Spectralis

    3. An assessment of the quality of optical coherence tomography image acquisition

      Explore Home - Springer Cardiology
      An assessment of the quality of optical coherence tomography image acquisition

      Optical coherence tomography (OCT) provides excellent image resolution, however OCT optimal acquisition is essential but could be challenging owing to several factors. We sought to assess the quality of OCT pullbacks and identify the causes of suboptimal image acquisition. We evaluated 784 (404 pre-PCI; 380 post-PCI) coronary pullbacks from an anonymized OCT database from our Cardiovascular Imaging Core Laboratory. Imaging of the region-of-interest (ROI—lesion or stented segment plus references) was incomplete in 16.1% pullbacks, caused by pullback starting too proximal (63.7%), inappropriate pullback length (17.1%) and pullback starting too distal (11.4%). The quality of image ...

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      Mentions: UT Southwestern Medical Center Hiram G. Bezerra

    4. Optical coherence tomography evaluation of vertebrobasilar artery stenosis: case series and literature review

      Explore jnis.bmj.com Cardiology , Neurology
      Optical coherence tomography evaluation of vertebrobasilar artery stenosis: case series and literature review

      Background Intracranial vertebrobasilar artery stenosis is an important cause of ischemic stroke. With its high resolution, intravascular optical coherence tomography (OCT) provides detailed assessment of vessel wall features. It is widely applied to identify high-risk plaque in the cardiovascular system, but its use in the intracranial artery has been limited. Objective To explore, in this pilot study, the usefulness of OCT in imaging of the intracranial artery wall. Methods Between November 2017 and July 2018, four patients with severe intracranial vertebrobasilar artery stenosis were enrolled for preintervention OCT evaluation of the lesion artery. Stenosis was present in the basilar artery ...

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      Mentions: Nanjing University of Science and Technology

    5. Dispersion correction for optical coherence tomography by the stepped detection algorithm in the fractional Fourier domain

      Explore OSA | OSA Publishing
      Dispersion correction for optical coherence tomography by the stepped detection algorithm in the fractional Fourier domain

      Dispersion in optical coherence tomography (OCT) leads to a series of wavelength-dependent phase distortions, which cause degradation of axial resolution. Due to the lack of prior information or the complexity of an exhaustive search calculation, all-depth dispersion suppression can hardly be realized in practical cases, especially for high-speed processing and irregular-structure samples. This paper explores the understanding of the depth-dependent dispersion in the fractional Fourier domain (FRFD) and addresses a new method for dispersion correction based on the FRFD stepped detection algorithm that is able to adaptively compensate the dispersion at all depths of the sample. For the detection of ...

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    6. Macular Optical Coherence Tomography Angiography in Nephropathic Patients with Diabetic Retinopathy in Iran: A Prospective Case–Control Study

      Explore Home - Springer Ophthalmology
      Macular Optical Coherence Tomography Angiography in Nephropathic Patients with Diabetic Retinopathy in Iran: A Prospective Case–Control Study

      Background Diabetic macular ischemia (DMI) is an important category of diabetic retinopathy (DR) which leads to severe visual loss. Clinically, it is defined by an enlargement of the foveal avascular zone (FAZ) that can be detected by optical coherence tomography angiography (OCTA). Studies have described a relationship between renal disease and these changes in FAZ area. The aim of this study was to compare disturbances in FAZ area in diabetic patients with or without overt nephropathy. Methods Following approval of the ethics committee, we examined diabetic patients with retinopathy. Patients were divided into two groups of DR, namely, with overt ...

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    7. Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review

      Explore TVST Journal Ophthalmology
      Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review

      Artificial intelligence (AI)-based automated classification and segmentation of optical coherence tomography (OCT) features have become increasingly popular. However, its 3-dimensional volumetric nature has made developing an algorithm that generalizes across all patient populations and OCT devices challenging. Several recent studies have reported high diagnostic performances of AI models; however, significant methodological challenges still exist in applying these models in real-world clinical practice. Lack of large-image datasets from multiple OCT devices, nonstandardized imaging or post-processing protocols between devices, limited graphics processing unit capabilities for exploiting 3-dimensional features, and inconsistency in the reporting metrics are major hurdles in enabling AI for ...

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      Mentions: University of Washington National University of Singapore

    8. Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level

      Explore ScienceDirect Cardiology
      Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level

      Background There remains a residual risk for acute myocardial infarction (AMI) even with low low-density lipoprotein cholesterol (LDL-C) levels. This study aimed to characterize the culprit lesion morphology of AMI by optical coherence tomography (OCT) in patients with low LDL-C. Methods Four-hundred and nine culprit lesions of 409 patients with their first presentation of AMI imaged by OCT were investigated. OCT analysis included the presence of plaque rupture and thin-capped fibroatheroma (TCFA). Fibrous cap thickness and lipid length were also measured. Intravascular ultrasound (IVUS) was performed in 368 (90.0%) patients. OCT and IVUS findings were compared between patients with ...

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      Mentions: Tokyo Medical & Dental University Tsunekazu Kakuta Tetsumin Lee

    9. Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging

      Explore Nature Publishing Group Ophthalmology
      Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging

      Lipofuscin in the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF). A technical challenge to accurately quantify the FAF intensities, thus the lipofuscin concentration, is to compensate the light attenuation of RPE melanin. We developed the VIS-OCT-FAF technology to accomplish optical coherence tomography (OCT) and FAF simultaneously with a single broadband visible light source. We demonstrated that light attenuation by RPE melanin can be assessed and corrected using the depth-resolved OCT signals. FAF images from albino and pigmented rats showed that without compensation, FAF signals from pigmented rats are lower than that from albinos. After compensation ...

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      Mentions: Shuliang Jiao Duke University University of Miami

    10. Membrane fouling by clay suspensions during NF-like forward osmosis: Characterization via optical coherence tomography

      Explore ScienceDirect NDE/NDT
      Membrane fouling by clay suspensions during NF-like forward osmosis: Characterization via optical coherence tomography

      The use of a membrane with a relatively loose ‘active layer’ opened a new paradigm for the application of osmotically driven processes. An effective way of imparting the osmotic pressure difference across the ‘active layer’ is to employ divalent salts as the draw solute, whose negative effects on the organic fouling have been documented in the literature. This study was targeted on investigating the fouling by clay suspensions when performing the forward osmosis (FO) with a nanofiltration (NF)-like membrane. Optical coherence tomography (OCT) was exploited to analyze the fouling phenomena in a way of determining the critical point of ...

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      Mentions: University of Missouri

    11. SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study

      Explore LWW Online Ophthalmology
      SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study

      Purpose: To develop an optical coherence tomography angiography ( OCTA )-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization ( CNV ) secondary to age-related macular degeneration. Methods: In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes of 6 patients with CNV secondary to age-related macular degeneration were quantitatively analyzed using custom software. A lesion-centered zonal OCTA analysis technique—which portioned the field-of-view into zones relative to CNV boundaries—was developed to quantify the spatial dependence of CC flow deficits. Results: Quantitative, lesion-centered zonal analysis of CC OCTA images revealed highest flow-deficit percentages near ...

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      Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto

    12. A Deep Learning Approach in Rebubbling After Descemet's Membrane Endothelial Keratoplasty

      Explore LWW Online Ophthalmology
      A Deep Learning Approach in Rebubbling After Descemet's Membrane Endothelial Keratoplasty

      Purpose: To evaluate the efficacy of deep learning in judging the need for rebubbling after Descemet's endothelial membrane keratoplasty (DMEK). Methods: This retrospective study included eyes that underwent rebubbling after DMEK ( rebubbling group: RB group) and the same number of eyes that did not require rebubbling (non-RB group), based on medical records. To classify the RB group, randomly selected images from anterior segment optical coherence tomography at postoperative day 5 were evaluated by corneal specialists. The criterion for rebubbling was the condition where graft detachment reached the central 4.0-mm pupil area. We trained nine types of deep neural ...

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      Mentions: Jichi Medical University

    13. Impact of optical coherence tomography‐derived neointimal tissue morphology on development of very late in‐stent restenosis

      Explore Wiley Online Library Cardiology
      Impact of optical coherence tomography‐derived neointimal tissue morphology on development of very late in‐stent restenosis

      Objectives This study evaluated the progression of very late in‐stent restenosis (VL‐ISR) by analyzing four serial coronary angiography (CAG) images and its correlation with neointimal tissue characterization of the VL‐ISR lesions on optical coherence tomography (OCT). Background Recently, VL‐ISR is occasionally observed beyond a few years after drug‐eluting stents (DESs) implantation. Methods This study analyzed 50 VL‐ISR lesions after DES in which 4 serial CAGs over a period of 2 years, including at baseline procedure, 9 months after baseline procedure, 12 months before VL‐ISR, and at the time of VL‐ISR, were performed ...

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      Mentions: Kenichi Fujii

    14. Handheld volumetric manual compression‐based quantitative micro‐elastography

      Explore Wiley Online Library
      Handheld volumetric manual compression‐based quantitative micro‐elastography

      Compression optical coherence elastography typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilises bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realising compact, actuator‐free, handheld compression optical coherence elastography. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative micro‐elastography (QME ...

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      Mentions: University of Western Australia Andrea Curatolo Brendan F. Kennedy

    15. Noninvasive Techniques for Quantification of Contact Dermatitis

      Explore Home - Springer Dermatology

      The pathophysiology of contact dermatitis includes specific morphological and physiological changes in the skin as a result of the direct toxic effect of exogenous agents and the subsequent inflammatory cascade. These reactions can be quantified by a variety of noninvasive devices. Classical biophysical methods such as the assessment of transepidermal water loss, stratum corneum hydration, and laser Doppler flowmetry are widely used in the investigation, quantification, and discrimination of irritant and allergic reactions of the skin. Novel in vivo techniques such as in vivo Raman spectroscopy have emerged, and the body of evidence on the skin microstructure is growing. Visualization ...

      Read Full Article
      16. See all articles
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  6. Organizations in the News

    1. (5 articles) National Institutes of Health
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    1. (2 articles) James G. Fujimoto
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    12. (1 articles) Victor X. D. Yang
    13. (1 articles) Nadia K. Waheed
    14. (1 articles) Tsunekazu Kakuta
    15. (1 articles) Francesco Bandello

  8. OCT Companies in the News

    1. (3 articles) Heidelberg Engineering
    2. (1 articles) Optovue
    3. (1 articles) Conavi Medical Inc.
    4. (1 articles) Dyad Medical
    5. (1 articles) Topcon Medical Systems
    6. (1 articles) Tomey Corporation
    7. (1 articles) Haag-Streit
    8. (1 articles) Voxeleron
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    1. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    2. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    3. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    4. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    5. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen
    6. We hope that this new lab between SNEC-SERI and NTU will be the start of an important programme to utilise engineering solutions to help and improve care of our patients with eye problems.
      By Tin Aung
    7. “At PhotoniCare we set out to solve the massive problem of frequent misdiagnosis of middle ear infections, and the overuse of antibiotics and referrals to surgery in children that result...We thank the FDA for clearing our TOMi Scope under a new product code unique to our technology, and look forward to bringing this innovation to doctors and patients very soon.”
      By Ryan L. Shelton
    8. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    9. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    10. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt