1. Feature Of The Week: Automated Classification of OCT Images for the Diagnosis of Oral Malignancy in the Hamster Cheek Pouch

    Most studies evaluating the potential of optical coherence tomography (OCT) for the diagnosis of oral cancer are based on visual assessment of OCT B-scans by trained experts. Human interpretation of the large pool of data acquired by modern high-speed OCT systems, however, can be cumbersome and extremely time consuming. Development of image analysis methods for automated and quantitative OCT image analysis could therefore facilitate the evaluation of such a large volume of data. We report automated algorithms for quantifying structural features that are associated with the malignant transformation of the oral epithelium based on image processing of OCT data. The features extracted from the OCT images were used to design a statistical classification model to perform the automated tissue diagnosis. The sensitivity and specificity of distinguishing malignant lesions from benign lesions were found to be 90.2% and 76.3%, respectively. The results of the study demonstrate the feasibility of using quantitative image analysis algorithms for extracting morphological features from OCT images to perform the automated diagnosis of oral malignancies in a hamster cheek pouch model.

    For more information see recent Article. Courtesy Brian Applegate and Paritosh Pande from Texas A&M University. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

      Read Full Article
    2. Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT

      Purpose To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber ...

      Read Full Article
    3. Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images

      Speckle reduction in optical coherence tomography (OCT) images plays an important role in facilitating further image analysis. Existing despeckling methods generally tend to provide insufficient speckle suppression or limited detail preservation especially at high speckle corruption. To address this problem, this paper proposes a novel iterative nonlocal means (NLM) method to restore OCT images. Different from the classical NLM method, the proposed method computes the weight using an improved weight function in an iterative way and it determines the decay parameter based on the classification of image pixels. The experiments on the clinical OCT images indicate that the proposed method ...

      Read Full Article
    4. Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography

      Purpose To compare foveal shapes in Koreans according to age and gender using spectral domain optical coherence tomography (SD-OCT). Methods This study included 230 eyes of 115 healthy adults. The subjects were divided into three groups: group 1 (20-39 years of age), group 2 (40-59 years of age) and group 3 (60-79 years of age). Using spectralis OCT, we measured central foveal thickness (CFT), regional maximal retinal thickness (MRT), pit diameter and pit depth and compared the differences between the groups. Results The MRT of the superior, inferior and nasal sides in group 1 was higher than in groups 2 ...

      Read Full Article
    5. Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. The meeting will be organised around 2-3 invited talks, technical sessions with poster sessions interspersed. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. There is no fee for this meeting, however registration is required. Tea, coffee and lunch will be provided for attendants. Please email Mark.Dickinson@manchester.ac.uk or P.H.Tomlins@qmul.ac.uk or N.Krstajic@ed.ac.uk in ...

      Read Full Article
    6. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

      Read Full Article
    7. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

      Read Full Article
    8. Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects

      The purpose of this study was to determine the within-session variability and between-session repeatability of spectral Fourier-domain optical coherence tomography (Doppler FD-OCT) Doppler retinal blood flow measurements in young, and elderly subjects. Methods: Doppler FD-OCT blood flow was measured using the RTVue system (Optovue Inc., USA). One eye of each of 20 healthy young (24.7 ± 2.7 years) and 16 healthy elderly (64.6 ± 5.1 years) subjects was randomly selected and the pupil was dilated. The double circular scanning pattern of the RTVue was employed. Six Doppler FD-OCT measurements (i.e. each separate measurement comprising an upper, and ...

      Read Full Article
    9. Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts

      Purpose:To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure (PMAC) eyes, mature cataract eyes and their fellow eyes, and identify those parameters that could be used to differentiate PMAC eyes from those with mature cataract and no PMAC. Methods:In this cross-sectional study a total of 33 PMAC subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth(ACD), anterior chamber area(ACA), iris thickness, iris curvature, lens vault(LV), and angle parameters including angle opening distance(AOD750) and trabecular ...

      Read Full Article
    10. MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, debuted its NITID TM skin imaging system at the 23 rd Annual European Academy of Dermatology and Venereology Congress in Amsterdam. NITID is a handheld diagnostic device designed to help dermatologists quickly and minimally invasively diagnose skin cancer. Once approved by regulatory bodies, it will be the first point-of-care OCT imaging device that can produce dynamic, real-time, high-resolution diagnostic images with tissue penetration capability of up to two millimeters. “NITID is the result of a decade of research in optical miniaturization technology, and we are thrilled to ...

      Read Full Article
    11. Depth extension and sidelobe suppression in optical coherence tomography using pupil filters

      Depth extension and sidelobe suppression in optical coherence tomography using pupil filters

      We demonstrate a new focus engineering scheme to achieve both extended depth of focus (DOF) and sidelobe suppression in spectral-domain optical coherence tomography (SD-OCT) system. Each of the illumination pupil function and the detection pupil function is modulated using an annular pupil filter implemented by center obscuration. The two pupil filters are arranged in a dark-field configuration such that the first sidelobe of the illumination point-spread function (PSF) matches the first minimum of the detection PSF in the lateral focal plane. We tested the feasibility of the proposed scheme numerically, and then constructed a dark-field OCT (DF-OCT) system to further ...

      Read Full Article
    12. COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM: Findings on Enhanced Depth Imaging Optical Coherence Tomography in Eight Eyes

      COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM: Findings on Enhanced Depth Imaging Optical Coherence Tomography in Eight Eyes

      Purpose: To assess combined hamartoma of the retina and retinal pigment epithelium with enhanced depth imaging optical coherence tomography. Methods: Retrospective, observational cases series in eight eyes of eight patients, with comparison between affected and unaffected eyes regarding enhanced depth imaging optical coherence tomography features of tumor, fovea, and choroid. Results: The mean age at presentation was 7 years. The tumor was macular (n = 5) or extramacular (n = 3). Enhanced depth imaging optical coherence tomography revealed irregularities in inner retina (n = 8) and/or all retinal layers (n = 3), with epiretinal membrane (n = 8), causing an inner retinal sawtooth (mini-peak ...

      Read Full Article
    13. TEMATYS is pleased to announce the release of its new market and technology report "Optical Coherence Tomography for Healthcare and Life Science: Technology and Market Trends"

      TEMATYS is pleased to announce the release of its new market and technology report "Optical Coherence Tomography for Healthcare and Life Science: Technology and Market Trends"

      Optical Coherence Tomography (OCT) is a mature technology well-established on the ophthalmology market. Currently, the ophthalmology OCT market has been slowing down for the last years. However, despite the saturation of the OCT ophthalmology market in developed countries, the OCT market for healthcare and life science is still expected to grow from around € 500M in 2013 to around € 1b in 2019. Strong demand from new biomedical applications, continuous development of innovative technologies, strong demand from developing countries will drive the OCT market growth. The present report provides market forecasts from 2014 to 2019 for the healthcare applications of OCT as ...

      Read Full Article
    14. Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Purpose To provide normal macular thickness measurements using Spectral Domain Optical Coherence Tomography (SDOCT, Copernicus, Optopol Technologies, Zawierci, Poland). Methods Fifty eight eyes of 58 healthy subjects were included in this prospective study. All subjects had comprehensive ophthalmic examination including best-corrected visual acuity (BCVA). All the subjects underwent Copernicus SDOCT. Central foveal thickness (CFT) and photoreceptor layer (PRL) thickness were measured and expressed as mean and standard deviation. Mean retinal thickness for each of the 9 regions defined in the Early Treatment Diabetic Retinopathy Study were reported. The data was compared with published literature in Indians using Stratus and Spectralis ...

      Read Full Article
    15. Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography

      Findings of secondary corneal amyloidosis  with ultrahigh-resolution optical coherence  tomography

      Purpose: To describe observations by ultrahigh-resolution optical coherence tomography (OCT) in a secondary corneal amyloidosis (SCA) patient with histological analysis of excised tissue. A unique finding under OCT of her fellow eye is also described. Case: A 39-year-old female had suffered from trichiasis in both of her eyes for more than 30 years. Slit-lamp examination showed a milky-white soft mass on her left cornea and a linear opacity on the fellow cornea at the cilia-attached region. OCT demonstrated the presence of a mass region within a thin epithelial layer and no destruction of Bowman’s layer in her left cornea ...

      Read Full Article
    16. See all articles
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (2 articles) Sun Yat-Sen University
    2. (2 articles) Medical University of Vienna
    3. (2 articles) University of Waterloo
    4. (2 articles) Texas A&M University
    5. (2 articles) University of Texas Health Science Center
    6. (2 articles) University of Southern California
    7. (1 articles) Korea University
    8. (1 articles) Konyang University
    9. (1 articles) Massachusetts General Hospital
    10. (1 articles) Massachusetts Institute of Technology
  3. People in the News

    1. (2 articles) Brian E. Applegate
    2. (1 articles) Molly Brewer
    3. (1 articles) Stefan G. Sacu
    4. (1 articles) Youbo Zhao
    5. (1 articles) Haohua Tu
    6. (1 articles) Mark R. Dickinson
    7. (1 articles) Nikola Krstajic
    8. (1 articles) William J. Feuer
    9. (1 articles) Brett E. Bouma
    10. (1 articles) Pete H. Tomlins
    11. (1 articles) Quing Zhu
    12. (1 articles) K. Bailey Freund
    13. (1 articles) Ursula Schmidt-Erfurth
    14. (1 articles) Siavash Yousefi
    15. (1 articles) Stephen A. Boppart
  4. OCT Companies in the News

    1. (2 articles) Carl Zeiss Meditec
    2. (2 articles) Topcon Medical Systems
    3. (1 articles) Optovue
    4. (1 articles) Optopol Technology
    5. (1 articles) MedLumics
  5. OCT Products in the News

    1. (4 articles) Zeiss Cirrus HD-OCT
    2. (2 articles) Heidelberg Spectralis
    3. (1 articles) Zeiss Visante OCT
    4. (1 articles) Zeiss Stratus OCT
    5. (1 articles) Optovue RTVue-100
  6. Picture Gallery

    All-fiber wavelength swept ring laser based on  Fabry-Perot filter for optical frequency domain  imaging Longitudinal necrotic shafts near TCFAs—A potential novel mechanism for plaque rupture to trigger ACS? Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data The Application of Optical Coherence Tomography to Image Subsurface Tissue Structure of Antarctic Krill Euphausia superba Capturing structure and function in an embryonic heart with biophotonic tools Correction of rotational distortion for catheter-based en face OCT and OCT angiography Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis OCT Angiography: The Next Era of OCT Technology Emerges Optical Coherence Tomography and Cryosurgery (Book Chapter) Frequency and predictors of thrombus inside the guiding catheter during interventional procedures: an optical coherence tomography study Anatomy of the fetal membranes using optical coherence tomography: Part 1 Widefield OCT with SPECTRALIS
  7. Recent Quotes

    1. NITID is the result of a decade of research in optical miniaturization technology, and we are thrilled to introduce it at EADV...NITID integrates three imaging modalities in one easy-to-use probe, thereby enabling physicians to produce high-quality images of a patient’s skin and determine whether skin cancer is present without an invasive biopsy. We believe NITID is a gateway into the future of personalized dermatology, supporting the introduction of new non-surgical treatments, and could not be more pleased with the positive reception and validation it received at EADV.
      By Eduardo Margallo Balbás
    2. Surgeons should have the choice of the best and most innovative products to maximize clinical outcomes, manage their data, and optimize their workflow...That is why we agreed to expand our customer reach in the United States by making our products available additionally through Abbott.
      By Ludwin Monz
    3. The concept of Heidelberg Engineering has always been to offer system platforms that customers can expand and upgrade with modules as needed, that are flexible and able grow with the organization...Our strategy to offer sustainable solutions has proven to be highly relevant to customers and it makes sense to follow this pathway with HEYEX PACS. Whether you want to integrate into major IT-infrastructures, interface with Electronic Health Record (EHR) systems, review imaging data from mobile devices or centralize all data; the possibilities will be virtually unlimited. Our goal is to enhance the performance and workflow efficiency of eye care professionals. I am confident that this will translate into better patient care and practice growth.
      By Kester Nahen
    4. While technology helps understand heart blocks better, FFR and OCT imaging techniques have completely changed the management scenario.
      By N Sathyabhama
    5. Our VivoSight OCT scanner is already proving popular with Dermatologists who are keen to deliver the best possible care to their non-melanoma skin cancer patients, and based on this initial feedback I am sure that the new improved probe with Micro-Camera will further accelerate the adoption of VivoSight OCT as a standard tool for the practising Dermatologist.
      By Jon Holmes
    6. I am very pleased and honored that my work has received such recognition from the NIH.
      By Christine Hendon
    7. We aim to demonstrate that Optical Coherence Tomography (OCT) can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium.
      By Christine Hendon
    8. Orion is our flagship product targeted at reading centers burdened with the laborious task of manual segmentation, CROs running clinical trials lacking relevant imaging-based biomarkers, and clinical researchers overwhelmed by data and hamstrung by the limited image analysis tools available...It is the most advanced OCT analysis software package available today, and our road map is comprehensive, including change analysis in the next release.
      By Jonathan D. Oakley
    9. As the interventional cardiology landscape has shifted to the treatment of more complex patients, intravascular imaging and fractional flow reserve have emerged as critical tools for enabling physicians to make more informed treatment decisions during PCI... “By integrating these tools directly into cath lab infrastructure, we can enhance access to technology and have them readily available during PCI procedures.
      By Gregg W. Stone
    10. PCI as a procedure has been around for decades, but only recently has the procedure been optimized by new diagnostic tools that can improve clinical outcomes...On demand FFR and OCT can support clinical decision making by providing highly-detailed intracoronary arterial views, which improves PCI, especially in complex cases. Furthermore, the resolution of OCT over intravascular ultrasound can be imperative in reducing challenges such as stent fracture and edge dissection.
      By Giovanni Gregori