1. Featured Articles

    1. Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Conavi Medical Inc. and Japan Lifeline are pleased to announce that they have received regulatory approval from the Ministry of Health, Labor and Welfare (MHLW) in Japan for the Novasight Hybrid TM intravascular imaging system. The Novasight Hybrid system is the world’s first clinical system capable of providing both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on a single imaging catheter. The system also has Health Canada approval and FDA 510(k) clearance in the USA. Japan Lifeline is the exclusive distributor for this technology in Japan. Dr. Brian Courtney, Conavi Medical’s Chief Executive Officer, comments that ...

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      Mentions: FDA Brian K. Courtney Conavi Medical Inc.

    2. Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Explore OSA | OSA Publishing NDE/NDT
      Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Silicon carbide (SiC) is widely used in high power electronic devices. However, defects on the SiC significantly reduce the yield and decrease the performance of SiC. Accurate detection of the defects is essential in the process control. We demonstrated a noninvasive three-dimensional (3D) defect detection method for SiC using optical coherence tomography (OCT). Defects including the triangular defects, hexagonal voids, grain boundaries, and carrot defects were inspected and analyzed on SiC wafers. The 3D images of defects acquired with OCT provided detailed information on the 3D structures and dimensions of defects, and the locations and orientations of the defects inside ...

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      Mentions: Pei Ma

    3. Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      A PostDoc position is available from March 1, 2020 at the Center for Medical Physics and Biomedical Engineering, Medical University of Vienna. We offer a research position in the field of biomedical imaging with strong interdisciplinary collaboration. Our research group is developing novel coherent biomedical imaging methods based on parallel OCT and digital adaptive optics to overcome the conventional resolution limits and to pave the way from pure structural to functional tissue and cell metabolic imaging. This involves profound knowledge of theoretical and experimental optics, system engineering, data and image processing, as well as hands-on experience in modern biomedical optics ...

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      Mentions: Rainer A. Leitgeb Medical University of Vienna

    4. Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Explore Wiley Online Library Developmental Biology
      Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Noninvasive visualization of embryos at different development stages is crucial for the understanding of the basic developmental biology. It is therefore desirable to have an imaging tool capable of rapidly evaluating the effects of gene manipulation or genome editing in developing embryos for the studies of gene functions and genetic engineering. Here, we propose and demonstrate a novel use of optical coherence tomography (OCT) to noninvasively exam the embryonic development of the migratory locusts in real time with 3‐dimensional (3D) view capability. In particular, we obtain the sufficiently high spatial resolution tomographic 2D and 3D images of live locust ...

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    5. Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Explore OSA | OSA Publishing Dermatology
      Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo . This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of ∼ 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal ...

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      Mentions: Arnaud Dubois Damae Medical

    6. Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Explore Wiley Online Library Ophthalmology
      Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Objective Optical coherence tomography (OCT) measurement of adult blue‐fronted parrots ( Amazona aestiva ), free from infectious, inflammatory or neoplastic systemic diseases and from any ophthalmological illness, aim at its characterization, as well as to standardize the examination technique for the species. Procedure Pupillary dilation was achieved with rocuronium bromide (5 mg/mL) at 0, 2, 15, 17, 30, and 32 minutes. The animals were sedated with midazolam maleate (0.5 mg/kg/IM) and anesthetized with propofol (5.0 mg/kg/IV). Measurements were made to evaluate the thickness of the total retina (TR), sensorineural retinal (SR), and ganglion cell ...

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    7. Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      Explore MDPI Open Access Journals Platform Tunable Sources
      Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      In this study, we present a swept source that can intelligently control its sweeping speed while satisfying the commercial stability and miniaturization standards. The source’s central wavelength of the output spectrum is 1300 nm and spectral width is greater than 100 nm. Meanwhile, the scan frequency can be adjusted to range from 20 to 100 kHz, and the stability degree of the optical capacity is less than 0.34%. Additionally, this study establishes a numerical model for the swept-source optical coherence tomography (SS–OCT) system and introduces a numerical simulation of the signal produced during the OCT imaging process ...

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    8. OCT Cost Effective, Useful Pre-Cataract Surgery

      Explore reviewofoptometry.com Ophthalmology
      OCT Cost Effective, Useful Pre-Cataract Surgery

      An estimated 64.4% of patients were willing to pay for the extra imaging step. For patients considering cataract surgery with a multifocal intraocular lens (IOL), optical coherence tomography (OCT) done prior to the procedure may increase the overall cost, but it also could be beneficial in detecting other macular pathologies and improving quality of life, a study in Ophthalmology reports. Based on their analysis, researchers found approximately 20.5% of patients undergoing cataract surgery may have macular pathologies, of which 11% may not be found during the initial clinical exam. The investigation’s base case was a 67-year-old male ...

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    9. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Explore LWW Online Gynecology
      Optical Vaginal Biopsy Using Optical Coherence Tomography

      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...

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      Mentions: Zhongping Chen UC Irvine Yan Li

    10. Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Explore ScienceDirect
      Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Intravital microscopy (IVM) and optical coherency tomography (OCT) are two powerful optical imaging tools that allow visualization of dynamic biological activities in living subjects with subcellular resolutions. Recent advances in labeling and label-free techniques empower IVM and OCT for a wide range of preclinical and clinical cancer imaging, providing profound insights into the complex physiological, cellular, and molecular behaviors of tumors. Preclinical IVM and OCT have elucidated many otherwise inscrutable aspects of cancer biology, while clinical applications of IVM and OCT are revolutionizing cancer diagnosis and therapies. We review important progress in the fields of IVM and OCT for cancer ...

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      Mentions: Stanford University Michigan State University Adam de la Zerda

    11. Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Explore ACS Publications Home Page
      Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Optical coherence tomography (OCT) has gained wide adoption in biological research and medical imaging due to its exceptional tissue penetration, 3D imaging speed and rich contrast. However, OCT plays a relatively small role in molecular and cellular imaging due to the lack of suitable biomolecular contrast agents. In particular, while the green fluorescent protein has provided revolutionary capabilities to fluorescence microscopy by connecting it to cellular functions such as gene expression, no equivalent reporter gene is currently available for OCT. Here we introduce gas vesicles, a class of naturally evolved gas-filled protein nanostructures, as genetically encodable OCT contrast agents. The ...

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      Mentions: California Institute of Technology UCSD OCT Medical Imaging Inc

    12. PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      Explore Optical Coherence Tomography News Otolaryngology , Other Business News
      PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced the company’s TOMi ™ Scope was awarded best healthcare product at the 12th Annual Prism Awards in San Francisco. The Prism Awards is an annual international competition that honors the best new optics and photonics products on the market. Since 2008, SPIE, along with media partner Photonics Media, has presented awards to companies and individuals that are creating products that make a difference, solve problems, and improve life through photonics. The Prism Awards reflect the exponential growth, exciting developments, and rich technical innovations ...

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      Mentions: Stephen A. Boppart FDA Ryan L. Shelton

    13. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Explore Nature Publishing Group Ophthalmology
      Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity associated findings collectively define the “Spaceflight Associated Neuro-ocular Syndrome” (SANS). We compare and contrast prior published work on SANS by the National Aeronautics and Space Administration’s (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. In this manuscript, we update and review the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). We ...

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      Mentions: Carl Zeiss Meditec

    14. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Explore RSC Publishing Home Urology
      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...

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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Peter E. Andersen

    15. Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for quantitative analysis of OCT/OCTA and machine learning based image classification. This position will be supported by a NIH project entitled differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy . The successful candidate should have a Ph.D. degree in ...

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      Mentions: National Institutes of Health Xincheng Yao

    16. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Explore American Physiological Society Journal Pulmonology
      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b -transgenic mice with ...

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      Mentions: Gereon Hüttmann University of Lübeck

    17. Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Inc. (“Acucela”), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), announced today that the company was invited to meet with NASA and the Translational Research Institute for Space Health (TRISH) *1 to present on January 30, 2020 the status of its Swept Source-OCT *2 (“SS-OCT”) device being developed for NASA’s Deep Space missions. The purpose of the meeting was to review and discuss progress of this Phase 1 project with the engineers, basic and medical scientists and program managers from NASA and TRISH. Additionally, a demonstration of the Phase 1 device ...

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      Mentions: Massachusetts Institute of Technology California Institute of Technology Baylor College of Medicine

    18. New OCT Image Analysis Capabilities From Wasatch Photonics

      Explore Optical Coherence Tomography News Other Business News
      New OCT Image Analysis Capabilities From Wasatch Photonics

      Wasatch Photonics is pleased to announce the expansion of our WP OCT Software and software development kits with new features to facilitate the translation of images into actionable information. These OCT image analysis capabilities lower the barrier to use for OCT by non-experts, and offer the potential for automated analysis of images in real time. The new features include image enhancement, layer segmentation, and classification functions based on powerful machine learning algorithms, and may be accessed from our user-friendly OCT image acquisition software or via our software development kits (SDKs). To help you see the possibilities, we have trained our ...

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      Mentions: Wasatch Photonics
    19. See all articles

  2. Recent Articles From Around The Web

    1. Beating Cancer - One Patient at a Time

      Explore Newswise Gastroenterology , Oncology
      Beating Cancer - One Patient at a Time

      Like most people, John Gifford wasn't looking forward to a colonoscopy when he arrived on the UCI Medical Center campus in Orange in 2018. The Riverside man, 65, was concerned about his family history of colorectal cancer and had dutifully scheduled an appointment with UCI Health gastroenterologist Dr. William Karnes. The exam turned out to be intriguing and enlightening - a far cry from what one expects during a colonoscopy, Gifford recalls with a laugh.

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      Mentions: National Institutes of Health California Institute of Technology UC Irvine

    2. Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan

      The laboratory has developed a minimally invasive screening method known as tethered capsule endomicroscopy (TCE) for imaging intestinal mucosa. With TCE, an unsedated subject swallows a tethered pill, which captures microscopic images of the entire esophagus, stomach, and small intestine, as it is naturally transits these organs via peristalsis and under the influence of gravity. The capsule implements a microscopic imaging technology called optical coherence tomography (OCT) that obtains 10-µm-resolution cross-sectional images of tissue. The procedure is brief, well tolerated, and can be much less expensive than endoscopy. The Investigators have implemented TCE for imaging the upper gastrointestinal tract ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    3. University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas

      University of Illinois at Chicago Receives a 2020 NIH Grant for $ 352,927 for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas. The principal investigator is Xincheng Yao. Below is a summary of the proposed work. This project is to investigate spatiotemporal interactions between neural activities and hemodynamic changes in the retina, and to explore quantitative mapping of retinal neurovascular coupling defects caused by neurodegenerative diseases. Retinal neurodegenerative diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR) and glaucoma, can produce severe vision losses if medical interventions cannot be provided promptly. As one ...

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      Mentions: National Institutes of Health Xincheng Yao

    4. Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents

      Explore Optical Coherence Tomography News Cardiology , Funding
      Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents

      Dyad Medical Receives a 2020 NIH Grant for $ 1,085,076 for Software For OCT Analysis of Vascular Stents. The principal investigator is Ronny Shalev. Below is a summary of the proposed work. Dyad Medical, Inc. will create intravascular Optical Coherence Tomography (IVOCT) software for clinical, live time determination of stent apposition and for offline analysis of stent implantation. Every year, 100s of thousands of patients in the US are treated with intravascular stents creating an opportunity for both solutions. Although advancements such as drug eluting metal stents hinder restenosis, there remains significant room for improvement. Stent design parameters include ...

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      Mentions: National Institutes of Health Dyad Medical

    5. Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health and Science University Receives a 2020 NIH Grant for $493,238 for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the eye, including the cornea, conjunctiva, sclera, anterior chamber, iris, and crystalline lens. Anterior segment OCT is already widely used in ophthalmology. But a number of high-impact applications were held back ...

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      Mentions: National Institutes of Health David Huang Oregon Health & Science University

    6. Optical coherence tomography and fractional flow reserve guided treatment of woven coronary artery anomaly presenting as acute myocardial infarction

      Explore LWW Online Cardiology
      Optical coherence tomography and fractional flow reserve guided treatment of woven coronary artery anomaly presenting as acute myocardial infarction

      Rationale: Woven coronary artery is a very rare congenital anomaly which may lead to acute coronary syndrome in previous literatures. At present, there is no consensus on the treatment of this coronary artery abnormality. Patient concerns: A 48-year-old male was admitted to the other hospital because of persistent chest pain. The electrocardiogram showed an ST-segment elevation in the v1-v5 lead and the patient was diagnosed with acute anterior myocardial infarction. Coronary angiography revealed 2 lumens in the proximal segment of the left anterior descending artery. Then the patient was transferred to our hospital for further diagnosis and treatment. Diagnoses: The ...

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      Mentions: Peking University

    7. Impact of manual correction over automated segmentation of spectral domain optical coherence tomography

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Impact of manual correction over automated segmentation of spectral domain optical coherence tomography

      Objective To study the automated segmentation of retinal layers using spectral domain optical coherence tomography (OCT) and the impact of manual correction over segmentation mistakes. Methods This was a retrospective, cross-sectional, comparative study that compared the automated segmentation of macular thickness using Spectralis™ OCT technology (Heidelberg Engineering, Heidelberg, Germany) versus manual segmentation in eyes with no macular changes, macular cystoid edema (CME), and choroidal neovascularization (CNV). Automated segmentation of macular thickness was manually corrected by two independent examiners and reanalyzed by them together in case of disagreement. Results In total, 306 eyes of 254 consecutive patients were evaluated. No statistically ...

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      Mentions: Universidade Federal de São Paulo Heidelberg Engineering Heidelberg Spectralis

    8. The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

      Explore LWW Online Ophthalmology
      The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

      We aimed to observe the opening status and morphological parameters of Schlemm's canal (SC) in normal eyes using enhanced depth imaging optical coherence tomography (EDI-OCT). Consecutive EDI-OCT scans were used to examine the right eye of 20 normal individuals . EDI-OCT was performed clockwise for 8 regions (at the 12:00, 1:30, 3:00, 4:30, 6:00, 7:30, 9:00 and 10:30 o’clock positions). Image processing and analysis in java software was used to measure the area, perimeter, and diameter of SC. Twenty-one serial scans of each region were evaluated and a total of 168 ...

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    9. Real-Time Intraoperative Dynamics of White Cataract- Intraoperative Optical Coherence Tomography Guided Classification & Management

      Explore LWW Online Ophthalmology
      Real-Time Intraoperative Dynamics of White Cataract- Intraoperative Optical Coherence Tomography Guided Classification & Management

      Purpose: To evaluate morphological characteristics and intraoperative dynamics of different types of white cataract using intraoperative optical coherence tomography (iOCT) Setting: Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India Design: Prospective interventional study Methods: Fifty eyes with white cataract undergoing phacoemulsification were evaluated. Primary outcome measure was classification of white cataract based on morphology and intraoperative dynamics on iOCT. Secondary outcome measure was rhexis related complications. Results: We identified four types of white cataract based on iOCT - Type I (18%), II (6%), III (48%) and IV (28%). Type I had regularly arranged lamellar ...

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    10. Quantitative Optical Coherence Tomography Angiography Biomarkers in a Treat-and-Extend Dosing Regimen in Neovascular Age-Related Macular Degeneration

      Explore TVST Journal Ophthalmology
      Quantitative Optical Coherence Tomography Angiography Biomarkers in a Treat-and-Extend Dosing Regimen in Neovascular Age-Related Macular Degeneration

      Purpose : To evaluate the association between quantitative optical coherence tomography angiography (OCT-A) parameters and clinical outcomes in treatment-naïve neovascular age-related macular degeneration (nAMD) patients treated with a treat-and-extend dosing regimen on a 12-month follow-up interval. Methods : Observational, prospective study of consecutive patients. The treatment protocol was based on a loading dose of three anti-vascular endothelial growth factor (VEGF) intravitreal injections (IVI) followed by a treat-and-extend regimen. Eyes were evaluated by swept-source OCT-A at baseline, 1 month after the loading dose and at 12 months. A quantitative analysis was issued for fractal dimension (FD), lacunarity index (LAC), blood flow surface ...

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      Mentions: Gabriel J. Coscas Centre Hospitalier Intercommunal de Créteil Eric H. Souied

    11. Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements

      Explore BJO Online Ophthalmology
      Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements

      Background/aims To assess the effect of partial posterior vitreous detachment (pPVD) on spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fibre layer thickness (RNFL) measurements. Methods Spectral-domain OCT RNFL thickness measurements were obtained from 684 consecutive patients who were seen in the Massachusetts Eye and Ear Glaucoma Service. Of these patients, we compared RNFL thickness measurements between 101 eyes of 101 glaucoma suspects who met inclusion criteria (55 eyes with and 46 eyes without pPVD). Results Among all 684 patients, 253 (37%) had pPVD in at least one eye. Among a subset of 101 eyes of 101 glaucoma suspects ...

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      Mentions: University of Wisconsin Harvard University Massachusetts Eye and Ear Infirmary

    12. D-OCT of Facial Telangiectasia Treated With IPL

      Explore Home - ClinicalTrials.gov Clinical Trials
      D-OCT of Facial Telangiectasia Treated With IPL

      Objectives: To examine whether dynamic Optical Coherence Tomography (OCT) could characterize vessel dimensions and blood flow of telangiectasias before and after treatment with Intense Pulsed Light (IPL). Methods: Dynamic-OCT (D-OCT) imaged telangiectasia characterized blood vessel width and depth, blood flow, and attenuation. Measurements were done immediately before and after, 1-3 days after, and 1 month after IPL treatment. Characterization of vessel dimensions at baseline were verified by a blinded observer. At one-month follow-up, clinical improvement was characterized as good, moderate or none and possible adverse effects were described.

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      Mentions: Michelson Diagnostics

    13. Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control

      Explore SPIE Digital Library Ophthalmology
      Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control

      Significance: Selective retina therapy (SRT) selectively targets the retinal pigment epithelium (RPE) and reduces negative side effects by avoiding thermal damages of the adjacent photoreceptors, the neural retina, and the choroid. However, the selection of proper laser energy for the SRT is challenging because of ophthalmoscopically invisible lesions in the RPE and different melanin concentrations among patients or even regions within an eye. Aim: We propose and demonstrate SRT monitoring based on speckle variance optical coherence tomography (svOCT) for dosimetry control. Approach: M-scans, time-resolved sequence of A-scans, of ex vivo bovine retina irradiated by 1.7-μs duration laser pulses ...

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      Mentions: Johns Hopkins University Jin U. Kang

    14. Optical coherence tomography features of retinal lesions in Chinese patients with endogenous Candida endophthalmitis

      Explore BMC Ophthalmology Ophthalmology
      Optical coherence tomography features of retinal lesions in Chinese patients with endogenous Candida endophthalmitis

      Background To evaluate the optical coherence tomography (OCT) features of retinal lesions in Chinese patients with endogenous Candida endophthalmitis (ECE). Methods We performed a retrospective review of patients diagnosed with ECE at one medical center. The medical records of the patients including predisposing risk factors, treatment and visual acuity were reviewed. And we focused on the analysis of OCT images of retinal lesions before and after treatment. Results A total of 16 Chinese patients (22 eyes) were included in this study. The most frequent predisposing risk factors were intravenous use of corticosteroids or antibiotics, lithotripsy for urinary calculi, and diabetes ...

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      Mentions: Fudan University

    15. Optical coherence tomography imaging after endovascular thrombectomy: a novel method for evaluating vascular injury in a swine model

      Explore thejns.org Cardiology , Neurology
      Optical coherence tomography imaging after endovascular thrombectomy: a novel method for evaluating vascular injury in a swine model

      Although studies have shown that some degree of iatrogenic endothelial injury occurs during endovascular thrombectomy (EVT), the clinical significance of such injury is uncertain. Furthermore, it is likely that iatrogenic effects such as endothelial denudation, intimal dissection, and tunica media edema will have varying clinical implications. The purpose of this study was to assess the feasibility of endovascular optical coherence tomography (OCT) in quantifying vessel injury in real time after EVT, correlate vessel injury with histological findings, and perform imaging at varying time intervals after EVT to assess the impact of prolonged direct exposure of the vessel to the thrombus ...

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      Mentions: Victor X. D. Yang Joel Ramjist
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    Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market Three-dimensional detection and quantification of defects in SiC by optical coherence tomography Post Doc Position for Optical Coherence Tomography at the Medical University Vienna Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva) Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source OCT Cost Effective, Useful Pre-Cataract Surgery Optical Vaginal Biopsy Using Optical Coherence Tomography Optical Microscopy and Coherence Tomography of Cancer in Living Subjects Genetically Encodable Contrast Agents for Optical Coherence Tomography PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

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    1. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    2. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    3. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    4. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen
    5. We hope that this new lab between SNEC-SERI and NTU will be the start of an important programme to utilise engineering solutions to help and improve care of our patients with eye problems.
      By Tin Aung
    6. “At PhotoniCare we set out to solve the massive problem of frequent misdiagnosis of middle ear infections, and the overuse of antibiotics and referrals to surgery in children that result...We thank the FDA for clearing our TOMi Scope under a new product code unique to our technology, and look forward to bringing this innovation to doctors and patients very soon.”
      By Ryan L. Shelton
    7. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    8. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    9. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    10. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart