1. Recent Articles From Around The Web

    1. In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

      In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

      Corneal collagen cross-linking (CXL) strengthens the biomechanical properties of damaged corneas. Quantifying the changes of stiffness due to different CXL protocols is difficult, especially in vivo . A noninvasive elastic wave-based optical coherence elastography system was developed to construct in vivo corneal elasticity maps by excitation of air puff. Biomechanical differences were compared for rabbit corneas given three different CXL protocols while keeping the total energy delivered constant. The Young’s modulus was weaker in corneas treated with higher irradiance levels over shorter durations, and a slight increase of Young’s modulus was present in all groups one week after the ...

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    2. The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension

      The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension

      Background: Recently, optical coherence tomography (OCT) has enhanced our understanding of visual disturbances in idiopathic intracranial hypertension (IIH). Its importance in the evaluation process of IIH has been established; however, there are many unknown aspects regarding the relationship of OCT measurements with several clinical features of IIH. Herein, we aimed to investigate the associations of OCT measurements with neuroimaging findings and some clinical parameters in our cohort with IIH. Methods: Patients over 18 years of age presenting to the neurology and neuro-ophthalmology outpatient clinics, between 2017 and 2019, who were diagnosed with IIH were included in the study. Cranial magnetic ...

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    3. Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography

      Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography

      Endoscopic optical coherence tomography is an interference based imaging technique which due to its micron level resolution ability found several applications in medical diagnostics. However, the standard image performance suffers from artefacts caused by dispersion imbalance and polarisation mismatches between reference and sample arm. Such artefacts can be minimised with the use of a special class of probes called common path probes where the reference surface is placed in the vicinity of the sample. Previously reported common path probes suffered from a compromise between sensitivity and resolution. In most cases, proposed probes were not scalable for industrial applications and required ...

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    4. Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

      Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

      Background: Optical coherence tomography angiography (OCTA) allows the detailed evaluation of retinal and choroidal microvascular structures with no need for a contrast agent. Pseudoexfoliation (PEX) is a condition that leads to anatomical and functional losses due to the accumulation of degraded abnormal fibrillar material in the intraocular and extraocular tissues. Histopathological studies have shown that the accumulation of PEX material in vascular structures may play a role in different pathologies such as retinal vein occlusion, iris hypoperfusion, anterior segment hypoxia, retinal arterial occlusion, and neovascular glaucoma. Aims: To evaluate and compare flow and vascular density in the retina and choroid ...

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    5. Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Purpose To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I-125) plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design Longitudinal prospective study of 21 subjects undergoing treatment for uveal melanoma with I-125 plaque brachytherapy. Eyes with melanoma were imaged with OCTA prior to treatment and at 12 month intervals until 2 years post-brachytherapy. Participants After IRB-approval, participants were enrolled prospectively from an academic ocular oncology clinic. Patients with low vision of < 20/200 in the eye with tumor at baseline were excluded. Methods Peripapillary (4.5 x 4.5-mm) and macular ...

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    6. Morphometric characteristics of the optical disc and thickness of retinal nerve fibre layer using Cirrus 5000 optical coherence tomography in healthy patients attending the National Institute of Ophthalmology

      Morphometric characteristics of the optical disc and thickness of retinal nerve fibre layer using Cirrus 5000 optical coherence tomography in healthy patients attending the National Institute of Ophthalmology

      Objective To describe the morphometric characteristics and thickness of the retinal nerve fibre layer (CFNR) in healthy patients using optical coherence tomography. Methods A cross-sectional and descriptive study was conducted on a total of 184 eyes of 184 people of mestizo origin enrolled after a complete ophthalmological evaluation at the National Institute of Ophthalmology, Lima-Peru. The morphometric parameters of the optic disc and thickness of the CFNR were measured by optical coherence tomography ZEISS CIRRUS™ HD-OCT Model 5000 (Carl Zeiss Inc., Dublin, CA, EE.UU). Megalopapilla was defined as: area of the optical disc greater than 2.5 mm 2 ...

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    7. Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques with a mean age of 4.91 ± 0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean ...

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    8. Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography

      Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography

      In this document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application of OCT/OFDI to guide percutaneous coronary interventions.

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    9. Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer

      Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer

      Purpose To compare biometry and prediction of postoperative refractive outcomes obtained by two swept-source optical coherence tomography (SS-OCT) biometers (IOLMaster 700 and Argos), and a partial coherence interferometry (IOLMaster ver 5.4) Methods Biometric values were measured using two SS-OCT and PCI device and evaluated against one another. Predictive errors were compared at one month after cataract surgery. Results One hundred forty six eyes were considered. Axial length (AXL) measurements were not successful in 3 eyes measured by IOLMaster 700 and Argos devices, and in 17 eyes measured by IOLMaster ver. 5.4 devices. AXL as measured by Argos showed ...

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    10. Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Microvascular changes are one of the early symptoms of retinal diseases. Recently developed optical coherence tomography angiography (OCTA) technology allows visualization and analysis of the retinal microvascular network in a non-invasive way. However, automated analysis of microvascular changes in OCTA is not a trivial task. Current approaches often attempt to directly segment the microvasculature. These approaches generally have problems in cases of poor image quality and limited visibility of the vasculature. Evaluating the quality of the results is also challenging because of the difficulty of manually tracing the microvasculature, especially in cases of low image quality or with images with ...

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    11. Structure-Aware Noise Reduction Generative Adversarial Network for Optical Coherence Tomography Image

      Structure-Aware Noise Reduction Generative Adversarial Network for Optical Coherence Tomography Image

      Optical coherence tomography (OCT) is a common imaging examination in ophthalmology, which can visualize cross-sectional retinal structures for diagnosis. However, image quality still suffers from speckle noise and other motion artifacts. An effective OCT denoising method is needed to ensure the image is interpreted correctly. However, lack of paired clean image restricts its development. Here, we propose an end-to-end structure-aware noise reduction generative adversarial network (SNR-GAN), trained with un-paired OCT images. The network is designed to translate images between noisy domain and clean domain. Besides adversarial and cycle consistence loss, structure-aware loss based on structural similarity index (SSIM) is added ...

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    12. Automated detection of glaucoma using optical coherence tomography angiogram images

      Automated detection of glaucoma using optical coherence tomography angiogram images

      Glaucoma is a malady that occurs due to the buildup of fluid pressure in the inner eye. Detection of glaucoma at an early stage is crucial as by 2040, 111.8 million people are expected to be afflicted with glaucoma globally. Feature extraction methods prove to be promising in the diagnosis of glaucoma. In this study, we have used optical coherence tomography angiogram (OCTA) images for automated glaucoma detection. Ocular sinister (OS) from the left eye while ocular dexter (OD) were obtained from right eye of subjects. We have used OS macular, OS disc, OD macular and OD disc images ...

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    13. 3D-CNN for Glaucoma Detection Using Optical Coherence Tomography

      3D-CNN for Glaucoma Detection Using Optical Coherence Tomography

      The large size of raw 3D optical coherence tomography (OCT) volumes poses challenges for deep learning methods as it cannot be accommodated on a single GPU in its original resolution. The direct analysis of these volumes however, provides advantages such as circumventing the need for the segmentation of retinal structures. Previously, a deep learning (DL) approach was proposed for the detection of glaucoma directly from 3D OCT volumes, where the volumes were significantly downsampled first. In this paper, we propose an end-to-end DL model for the detection of glaucoma that doubles the number of input voxels of the previously proposed ...

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    14. U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography

      U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography

      The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task. In the second approach, the surrounding retinal layers (outer boundary retinal pigment epithelium (OBRPE) and Bruch’s membrane (BM)) are segmented and the remaining space between these two layers is extracted as drusen. In this work, we extend the standard U-Net architecture with spatial pyramid pooling components to introduce global feature ...

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    15. Optical coherence tomography analysis of inner and outer retinal layers in eyes with chiasmal compression caused by suprasellar tumours

      Optical coherence tomography analysis of inner and outer retinal layers in eyes with chiasmal compression caused by suprasellar tumours

      Purpose To compare postoperative macular thickness measurements of inner and outer retinal layers in eyes of patients with chiasmal compression with or without visual field (VF) recovery and healthy controls using optical coherence tomography (OCT). Methods Macular spectral‐domain OCT has been used for the auto‐segmentation of images obtained from 100 eyes affected with chiasmal compression compared with 100 healthy controls enrolled in this study. We have divided eyes with chiasmal compression into two groups: group 1 characterized by VF recovery after tumour excision and group 2 showing partial or no recovery of VF. The thickness of the macular ...

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    Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice Metasurface-based focus-tunable mirror Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for  Optical Coherence Tomography” Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery Advances In Intraoperative OCT Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging OCT-Based Tooth Scan and Reconstruction
  6. Recent Quotes

    1. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    2. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    3. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    4. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    5. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    6. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    7. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    8. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    9. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    10. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney