1. Featured Articles

    1. High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      Explore jstage.jst.go.jp Probes
      High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      We developed an endoscopic microscopy system with 20 nm accuracy that affords inspection through narrow gaps using a thin, 1.5 mm diameter probe. Accuracy was improved using Optical Coherence Tomography (OCT). The frequency modulated light source is stabilized with closed control from self-interference measurement. The probe is driven by two miniature motors, which allow three-dimensional scanning of an internal surface. Imaging performance is 60 frames per second. The high accuracy with narrow clearance capabilities of this system reduces the need for machine overhauls, which affords trustworthy daily inspections and hence greater machine reliability.

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    2. Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz

      Explore bioRxiv.org Ophthalmology
      Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz

      bjective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A-scans at 1.64MHz with a center wavelength of 1063nm, and an AO subsystem providing diffraction-limited imaging. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well ...

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      Mentions: John S. Werner Robert J. Zawadzki UCSD

    3. Heidelberg Engineering OCT Angiography Module Now Available in the United States

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Heidelberg Engineering OCT Angiography Module Now Available in the United States

      OCTA is a key component of the SPECTRALIS portfolio, delivering on the platform’s upgradeability and multimodal image capabilities. Heidelberg Engineering, a privately-held imaging solutions company focused on advanced diagnostic instruments and IT solutions for eye care professionals, announced today that it has received US Food and Drug Administration (FDA) clearance for its OCT Angiography Module (OCTA). The additional module is now available for new and existing SPECTRALIS® upgradeable diagnostic imaging devices. “We are excited to announce this FDA clearance as further validation not only of OCTA technology in the industry, but also of our commitment to meeting the highest ...

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      Mentions: Heidelberg Engineering Tufts University FDA

    4. Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Explore OSA | OSA Publishing Probes
      Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Fiber-based polarization-sensitive optical coherence tomography (PS-OCT) that utilizes a rotationally-scanning catheter has a variety of potential biomedical applications in luminal organ systems due to its ability to provide intrinsic contrast for birefringent tissue. Incorporating the optic axis (OA) of the tissue greatly enhances this potential by also permitting information about the orientation of the tissue to be extracted; however, measurement distortion that occurs has up to this point made it impossible to obtain accurate sample OA measurements. In this paper we present a straightforward calibration technique that allows the sample OA to be recovered. This technique requires no hardware modifications ...

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      Mentions: Massachusetts General Hospital Harvard University Melissa J. Suter

    5. First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      Explore Neurointervention Cardiology , Neurology
      First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      A 64-year-old female presented with an incidentally-discovered right posterior inferior cerebral artery (PICA) aneurysm, initially treated in 2015 by simple coiling. Follow-up demonstrated significant coil compaction that required retreatment. Retreatment was done uneventfully using a Pipeline embolization device (PED) shield deployed starting from the basilar artery and ending at the V4 segment of the vertebral artery. Eight-weeks post-deployment, a follow-up digital subtraction imaging (DSA) and intravascular imaging with optical coherence tomography were obtained. The intravascular imaging demonstrated that the flow diverter had good wall apposition and concentric neointimal growth over the braid with exception to the areas that the PED ...

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      Mentions: St. Jude Medical

    6. Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia

      Explore Home - ClinicalTrials.gov Gastroenterology , Clinical Trials
      Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia

      Patients with Barrett's Esophagus (BE) undergoing endoscopic therapy through our Barrett's Esophagus Unit will be approached for study enrollment. Patients with no endoscopic evidence of BE will be considered for the study. Surveillance biopsies will be obtained per standard clinical protocol and reviewed to confirm absence of intestinal metaplasia. Patients who have achieved complete eradication of intestinal metaplasia (CRIM) will be enrolled in the study and will undergo the Nvision® Imaging System (VLE). Patients enrolled in the study will undergo clinical follow-up consisting of surveillance endoscopy every 3 months for 1 year. Surveillance endoscopy intervals may be prolonged ...

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      Mentions: NinePoint Medical

    7. OCT Promising as Clear Point-of-Care Solution

      Explore Photonics.com
      OCT Promising as Clear Point-of-Care Solution

      Medical devices at the point of care allow clinicians to do what they do best: determine a patient’s exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a steep learning curve or worry about the underlying scientific principles, and without the high cost seen for so many medical technologies. Optical coherence tomography (OCT) is an imaging technology that has become well-known in recent years for its proven diagnostic ability, particularly in the eye care realm. This technology is now the gold standard for diagnosing eye diseases such as ...

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      Mentions: Duke University Adam Wax

    8. First workshop on artificial intelligence applied to retinal image analysis, Perth Australia, December 2018.

      Explore Philippe Burlina Ophthalmology
      First workshop on artificial intelligence applied to retinal image analysis, Perth Australia, December 2018.

      Medical imaging has now embraced AI methods based on deep learning (DL) approaches for medical image analytics. This has been especially true for retinal image analysis where large annotated datasets have been available for over 10 years. Recent studies starting in 2016 have demonstrated on par with human performance for diagnostic tasks such as screening for diabetic retinopathy and macular degeneration. Recently, in 2018, the FDA approved the first software device for retinal diagnostics. The goal of this workshop is to showcase recent developments in AI for retinal image analysis and as a follow up on recent meetings at ARVO ...

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      Mentions: FDA Delia Cabrera DeBuc

    9. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

      A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on interdisciplinary projects in the field of optical imaging and real-time image processing. Ph.D. in Optics, Biomedical Engineering, Electrical Engineering, Computer Science or a related field is required. Demonstrated excellence in one or more of the following areas is required: expertise in optical coherence Tomography, scanning laser ophthalmoscope and adaptive optics, optical/electrical system design, prototyping and simulation, data acquisition and system control/synchronization, and C++/GPU ...

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      Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers

    10. Simple approach for aberration-corrected OCT imaging of the human retina

      Explore OSA | OSA Publishing Ophthalmology
      Simple approach for aberration-corrected OCT imaging of the human retina

      Aberration-corrected imaging of human photoreceptor cells, whether hardware or software based, presently requires a complex and expensive setup. Here we use a simple and inexpensive off-axis full-field time-domain optical coherence tomography (OCT) approach to acquire volumetric data of an in vivo human retina. Full volumetric data are recorded in 1.3 s. After computationally correcting for aberrations, single photoreceptor cells were visualized. In addition, the numerical correction of ametropia is demonstrated. Our implementation of full-field optical coherence tomography combines a low technical complexity with the possibility for computational image correction.

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      Mentions: Gereon Hüttmann Reginald Birngruber University of Lübeck

    11. NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering

      Explore nibib.nih.gov
      NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering

      National Institutes of Health Director Francis S. Collins, M.D., Ph.D., has selected Bruce J. Tromberg, Ph.D., as director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). A pioneering leader in the field of bio photonics, Dr. Tromberg is currently a professor at the University of California at Irvine (UCI), with dual appointments in the Departments of Biomedical Engineering and Surgery. He is also director of UCI’s Beckman Laser Institute and Medical Clinic, an interdisciplinary research, teaching and clinical center for optics and photonics in biology and medicine. He is expected to join NIH in ...

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      Mentions: National Cancer Institute National Institutes of Health Vanderbilt University

    12. Clinical and surgical implications of intraoperative optical coherence tomography imaging for benign pediatric vocal fold lesions

      Explore ScienceDirect Otolaryngology
      Clinical and surgical implications of intraoperative optical coherence tomography imaging for benign pediatric vocal fold lesions

      Introduction Benign vocal disorders in children include an extensive list of abnormalities creating a variety of debilitating levels of dysphonia. Precise delineation of the benign lesion type and margins may have significant public health implications in children. An innovative technology such as optical coherence tomography (OCT) is being explored to delineate pediatric benign laryngeal lesions. An accurate assessment of the subepithelial morphology may help towards tailoring more personalized therapeutic treatments. This study was established to highlight key morphological and optical features of benign pediatric laryngeal lesions using intraoperative OCT and to suggest clinical implications that arise from such optical imaging ...

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      Mentions: Harvard University Massachusetts Eye and Ear Infirmary

    13. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      Explore OSA | OSA Publishing Probes
      High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in ...

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      Mentions: Robert A. Huber Gereon Hüttmann University of Lübeck

    14. Watching an embryo's neural tube close

      Explore EurekAlert! Developmental Biology
      Watching an embryo's neural tube close

      In those precious weeks before a woman even realizes she's pregnant, an embryo will have already developed a neural tube, a hollow structure made of cells which will eventually become the brain and spinal cord. Now, with $3.2 million from the National Institutes of Health, UH professor of biomedical engineering Kirill Larin will tackle the evolutionary anomaly of why the neural tube closes in most embryos but remains open in others, leading to birth defects such as spina bifida and anencephaly. Neural Tube Defects (NTD) are the second most common structural birth defect in humans, affecting upwards of ...

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      Mentions: University of Maryland National Institutes of Health Baylor College of Medicine

    15. Dr. Philip J. Rosenfeld to give Jackson Memorial Lecture at Opening Session of AAO 2018

      Explore American Academy of Ophthalmology Ophthalmology
      Dr. Philip J. Rosenfeld to give Jackson Memorial Lecture at Opening Session of AAO 2018

      Dr. Philip J. Rosenfeld is currently Director and Professor of Ophthalmology at the Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine. His primary clinical and research interests are in age-related macular degeneration (AMD). He is at the forefront of medical science having spent decades seeking effective therapies for AMD as the principal investigator and study chairman for numerous AMD clinical trials. He was instrumental in the clinical development of anti-VEGF therapies, the use of optical coherence tomography (OCT) guided treatment regimens using anti-VEGF therapy, the clinical development of OCT instruments, and the development and use of novel ...

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      Mentions: Philip J. Rosenfeld University of Miami
    16. See all articles

  2. Recent Articles From Around The Web

    1. Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

      Explore Wiley Online Library Ophthalmology
      Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

      Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue ® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in ...

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      Mentions: Optovue

    2. Optical coherence tomography angiography and microvascular changes in diabetic retinopathy: a systematic review

      Explore Wiley Online Library Ophthalmology
      Optical coherence tomography angiography and microvascular changes in diabetic retinopathy: a systematic review

      To use optical coherence tomography angiography (OCTA) to evaluate foveal microvascular changes in diabetes by comparing the area of foveal avascular zone (FAZ) in healthy controls and patients with diabetes with no diabetic retinopathy (NDR) as well as different stages of diabetic retinopathy (DR). A systematic literature search was performed based on the population, intervention, comparison and outcome (PICO) strategy by two independent reviewers. The search was performed in PubMed, Embase and Cochrane Library, including keywords ‘diabetes mellitus’, ‘DR’ and ‘OCTA’. Of 358 studies initially identified, 215 studies were screened after duplicate removal. Of these, we included 12 (nine cross ...

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    3. A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis

      Explore BMC Ophthalmology Ophthalmology
      A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis

      Background Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. Methods This prospective case-control study involved 152 eyes from 143 optic neuritis (ON) patients. All the patients were divided into either the NMOSD-ON group or the IDON group based on the AQP4-Ab test. The retinal nerve fiber layer thickness (RNFLT), retinal thickness (RT), and choroidal ...

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    4. Ultra-wide optical coherence tomography angiography in diabetic retinopathy

      Explore Home Ophthalmology
      Ultra-wide optical coherence tomography angiography in diabetic retinopathy

      Background: To implement an ultra-wide optical coherence tomography angiography imaging (UW-OCTA) modality in eyes with diabetic retinopathy (DR) with the aim of quantifying the burden of microvascular disease at baseline and subsequent clinic visits. Methods: UW-OCTA was implemented on a 1,060 nm swept source (SS) OCTA engine running at 100 kHz A-line rate with a motion tracking mechanism. A montage scanning protocol was used to capture a 100-degree field of view (FOV) using a 4×4 grid of sixteen total individual 6×6 mm 2 scans. Typical OCTA images with a FOV of 3×3, 6×6 and 12 ...

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      Mentions: University of Washington Ruikang K. Wang

    5. Joint Segmentation and Uncertainty Visualization of Retinal Layers in Optical Coherence Tomography Images using Bayesian Deep Learning

      Explore arxiv.org Ophthalmology
      Joint Segmentation and Uncertainty Visualization of Retinal Layers in Optical Coherence Tomography Images using Bayesian Deep Learning

      Optical coherence tomography (OCT) is commonly used to analyze retinal layers for assessment of ocular diseases. In this paper, we propose a method for retinal layer segmentation and quantification of uncertainty based on Bayesian deep learning. Our method not only performs end-to-end segmentation of retinal layers, but also gives the pixel wise uncertainty measure of the segmentation output. The generated uncertainty map can be used to identify erroneously segmented image regions which is useful in downstream analysis. We have validated our method on a dataset of 1487 images obtained from 15 subjects (OCT volumes) and compared it against the state-of-the-art ...

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    6. Predictive accuracy of partial coherence interferometry and swept-source optical coherence tomography for intraocular lens power calculation

      Explore Nature Publishing Group Ophthalmology
      Predictive accuracy of partial coherence interferometry and swept-source optical coherence tomography for intraocular lens power calculation

      The purpose of this study is to compare the predictive accuracy of intraocular lens (IOL) calculations made with partial coherence interferometry (PCI, IOLMaster, version 5) and swept-source optical coherence tomography (SS-OCT, Argos). Axial length (AL), mean keratometry value (K), and anterior chamber depth (ACD) were obtained using PCI and SS-OCT optical biometers. Intraocular lens (IOL) power calculations were made using the Barret-Universal II, Haigis, Hoffer Q, SRK/T, and T2 formulas and compared the predictive accuracy between biometers. In 153 eyes (153 patients), axial length measurements made with PCI (24.65 ± 2.35 mm) and SS-OCT (24.62 ± 2.29 ...

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    7. Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes

      Explore LWW Online Ophthalmology
      Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes

      Purpose: To evaluate corneal epithelial thickness (CET) and corneal thickness (CT) in healthy eyes using spectral domain optical coherence tomography. Methods: Thirty-six healthy eyes were imaged using the Cirrus high-definition (HD)-optical coherence tomography device. The average CET and CT were assessed using Cirrus Review Software within predefined concentric corneal ring-shaped zones. Specific regions of CET (superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal, and inferonasal) were also assessed. The difference between zones was compared between males and females. Results: The average CET was 48.3, 47.1, 46.1, and 45.8 μm in the 4 concentric zones (0–2 ...

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      Mentions: Srinivas R. Sadda UCSF

    8. Relationship between filtering bleb vascularization and surgical outcomes after trabeculectomy: an optical coherence tomography angiography study

      Explore Home - Springer Ophthalmology
      Relationship between filtering bleb vascularization and surgical outcomes after trabeculectomy: an optical coherence tomography angiography study

      Purpose To explore the relationship between the bleb vasculature and surgical outcome after trabeculectomy (TRAB) using optical coherence tomography angiography (OCT-A). Methods A prospective study was conducted, which included 26 eyes of 26 primary glaucoma patients in the final analysis. Thereinto, six patients underwent TRAB combined 5-FU and 12 patients received subconjunctival 5-FU injection postoperation. The bleb vessel was evaluated using OCT-A 1 week, 2 weeks, 1 month, 3 months, and 6 months after TRAB. Intraocular pressure (IOP), filtering bleb height, and bleb wall thickness were recorded at the same time. Pearson’s correlation analysis and linear regression analysis were ...

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      Mentions: Soochow University

    9. Bimodal imaging of proliferative diabetic retinopathy vascular features using swept source optical coherence tomography angiography

      Explore 欢迎访问国际眼科杂志编辑部 Ophthalmology
      Bimodal imaging of proliferative diabetic retinopathy vascular features using swept source optical coherence tomography angiography

      AIM : To categorize neovessels morphology and to detect response to anti-angiogenic therapy by using structural and angiographic modes of swept source optical coherence tomography (SS-OCT). METHODS : Thirty-two eyes with neovessels at disc (NVD) and neovessels elsewhere (NVE) - as diagnosed by fluorescein angiography- were included. Cross sectional OCT images of disc and macular regions were registered to enface OCT angiography (OCTA), B-scan blood flow over lay and density maps. Three eyes received anti-angiogenic treatment. RESULTS : Pin point registration of cross-sectional OCT and OCTA images differentiated active NVD with vascular elements from fibrous or equivalent fibrovascular elements. En face images delineated NVE ...

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    10. Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy

      Explore LWW Online Ophthalmology
      Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy

      Purpose: To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). Methods: Twenty-two eyes (16 patients) being treated with preservative-containing topical medications and 12 normal eyes underwent anterior-segment optical coherence tomography imaging using RTVue-100. The CET maps generated corresponded to a 6-mm diameter area of cornea that was divided into 17 sectors. We compared the CETs of each sector obtained in the glaucomatous group with those obtained in the control group. Results: Glaucomatous eyes were divided into 2 ...

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      Mentions: Optovue RTVue-100

    11. En Face Imaging of Geographic Atrophy Using Different Swept-Source Optical Coherence Tomography Scan Patterns

      Explore ScienceDirect Ophthalmology
      En Face Imaging of Geographic Atrophy Using Different Swept-Source Optical Coherence Tomography Scan Patterns

      Purpose Different swept source optical coherence tomography (SS-OCT) scan patterns were used to image geographic atrophy (GA) to determine if they provided similar area and enlargement measurements in eyes with age-related macular degeneration (AMD). Design Prospective, observational case series. Participants Patients with GA secondary to non-exudative AMD Methods Patients were imaged using SS-OCT (PLEX Elite 9000 instrument, Carl Zeiss Meditec, Dublin, CA) with follow-up imaging performed after six months and one year. Both the 6x6 mm and 12x12 mm scan patterns were obtained at each visit. Area measurements of GA were performed on the en face images generated from a ...

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      Mentions: Giovanni Gregori Philip J. Rosenfeld Carl Zeiss Meditec

    12. Treatment Response in Sympathetic Ophthalmia as Assessed by Widefield OCT Angiography

      Explore Healio.com Ophthalmology
      Treatment Response in Sympathetic Ophthalmia as Assessed by Widefield OCT Angiography

      The authors report the widefield montage swept-source optical coherence tomography angiography (OCTA) findings in a 36-year-old male with sympathetic ophthalmia and illustrate the presence of multiple small areas of choriocapillaris flow voids that likely correspond to areas of choriocapillaris ischemia. Using sequential imaging, the authors observed that these flow voids improved following initiating of steroid and immunosuppressive therapy and almost completely resolved following 6 months of therapy with corresponding improvement in visual acuity. This report highlights the role of widefield montage OCTA to detect these likely ischemic changes within the choriocapillaris in sympathetic ophthalmia and demonstrates that they can be ...

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      Mentions: Duke University

    13. Familial Exudative Vitreoretinopathy Imaged With Optical Coherence Tomography Angiography

      Explore Healio.com Ophthalmology
      Familial Exudative Vitreoretinopathy Imaged With Optical Coherence Tomography Angiography

      The authors present a case of a 29-year-old man who presented to the Department of Ophthalmology at their institution to complete a peripheral laser treatment in his left eye for familial exudative vitreoretinopathy complicated by tractional macular edema.

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      Mentions: Giuseppe Querques Francesco Bandello Università Vita-Salute San Raffaele

    14. Optical Coherence Tomography Angiography Findings in X-Linked Retinoschisis

      Explore Healio.com Ophthalmology
      Optical Coherence Tomography Angiography Findings in X-Linked Retinoschisis

      BACKGROUND AND OBJECTIVE: The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). PATIENTS AND METHODS: Clinical and genetic assessments were performed in 12 family members. OCTA was performed at baseline (12 members including cases and carriers) and after acetazolamide administration (three cases). Twenty healthy subjects (20 eyes, controls) were chosen for comparison. Molecular genetic analysis of the RS1 gene was performed in all family members. RESULTS: Deep capillary plexus density was reduced in cases compared with controls ( P ...

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    15. The world at their feet

      Explore Nature Publishing Group
      The world at their feet

      As a summer intern at the private foundation Brain and Spine Institute (ICM) in Paris, Olivier Thouvenin helped develop an imaging technique for monitoring the neural circuitry in zebrafish larvae. But the method lacked the spatial resolution to tease apart connections between neurons at the single-cell level, which frustrated the young biophysics master’s student. So for his PhD at the Langevin Institute — two kilometres away on the edge of Paris’s famed Botanical Gardens — Thouvenin worked on improving an existing high-resolution tissue-imaging tool called full-field optical coherence tomography (OCT). He added a dynamic time element to the otherwise static ...

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      Mentions: Seoul National University Massachusetts Institute of Technology Princeton University
      16. See all articles
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    High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz Heidelberg Engineering OCT Angiography Module Now Available in the United States Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia OCT Promising as Clear Point-of-Care Solution First workshop on artificial intelligence applied to retinal image analysis, Perth Australia, December 2018. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University Simple approach for aberration-corrected OCT imaging of the human retina NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering Clinical and surgical implications of intraoperative optical coherence tomography imaging for benign pediatric vocal fold lesions

  10. Popular Articles This Week

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    1. The addition of OCT angiography to Heidelberg’s SPECTRALIS multimodal platform allows for the evaluation of retinal and choroidal vascular abnormalities in a noninvasive manner...I believe OCTA will soon become invaluable in our daily clinical routine for screening and diagnosing chorioretinal disorders.”
      By Nadia K. Waheed
    2. We will create this hybrid microscope putting these two powerful technologies together. OCT will image the development of the neural tube while at the same time, Brillouin spectroscopy will probe its mechanical properties. We will be imaging and sensing at the same time...If we find out what causes the tube to close, what is exactly happening, we can develop new drug treatments for at-risk embryos...It's still one of the great mysteries of life, no one on earth knows how this happens and that is really exciting to us, because we will be the ones to find out.
      By Kirill V. Larin
    3. The purported advantages of the synergistic information that IVUS and OCT can provide have been highly anticipated in the interventional cardiology community...These cases performed in Hamilton represent the first worldwide clinical use of any system that combines IVUS with OCT on a single catheter. In an era of personalized and precision medicine, we believe that the ability to collect comprehensive imaging data in patients with coronary artery disease (CAD) provides an important opportunity to generate improved clinical decision-making capabilities for these patients in the future.
      By Brian K. Courtney
    4. The Ganymede series has proven to be an excellent tool for a multitude of imaging applications,...The Thorlabs OCT application team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    5. I am honored and incredibly excited to take on this leadership role during such a pivotal point in the company’s history and look forward to working with Merit Medical on our new strategic partnership. I would like to extend my sincere thanks to Chris for his service to NinePoint and mentorship to me over the past four-years. I am fortunate to be surrounded by a truly talented team with exciting and innovative products in the pipeline. Together, we look forward to continuing our important mission towards early detection of cancer.
      By Eman Namati
    6. We are thrilled to receive marketing clearance for our innovative AngioAnalytics technology as part of the AngioVue System to aid physicians in the early detection and management of sight-threatening eye diseases in the U.S.,” said Jay Wei, founder and chief executive officer of Optovue. “Analytic measurement tools will shift the treatment paradigm because they provide an objective measure of treatment efficacy, thereby enabling truly customized patient management and improved patient care...The information provided by AngioAnalytics may help to change the clinical management of diabetic retinopathy, age-related macular degeneration and other diseases that progressively cause blindness for millions of people. We will continue to advance AngioAnalytics as we believe quantification is the gateway to widespread and global adoption of OCTA.
      By Jay Wei
    7. This is the world's first intravascular imaging system for clinical use with the capability to acquire both IVUS and OCT images using a single catheter. IVUS and OCT are the two most commonly used intravascular imaging technologies in addition to angiography...The Novasight Hybrid System provides the resolution and contrast of OCT with the larger field of view of IVUS, and displays the images in a precisely co-registered fashion.
      By Brian K. Courtney
    8. We started with middle ear infections because of our personal experience with this disease as both parents and patients. Our novel application of optical coherence tomography revolutionizes the diagnosis, treatment and monitoring of the middle ear infections that affect 80% of children.
      By Ryan L. Shelton
    9. With the assistance of the next generation Pantheris system, we helped restore blood flow within the previously blocked segment of the artery and most importantly achieved a great outcome for the patient.
      By Arne G. Schwindt
    10. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen