1. Featured Articles

    1. GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes

      Explore MDPI Open Access Journals Platform Broadband Sources , Tunable Sources
      GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes

      InPBi exhibits broad and strong photoluminescence at room temperature, and is a potential candidate for fabricating super-luminescence diodes applied in optical coherence tomography. In this paper, the strained InPBi quantum dot (QD) embedded in the AlGaAs barrier on a GaAs platform is proposed to enhance the light emission efficiency and further broaden the photoluminescence spectrum. The finite element method is used to calculate the strain distribution, band alignment and confined levels of InPBi QDs. The carrier recombinations between the ground states and the deep levels are systematically investigated. A high Bi content and a flat QD shape are found preferable ...

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    2. Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University

      x The School of Electrical & Electronic Engineering at the Nanyang Technological University invites applications for a postdoctoral fellow position in the area of high resolution optical coherence tomography (OCT) devices. The successful candidate will work on a collaborative research project with a focus on micro-optical coherence tomography, synthetic aperture endoscopy, and point-of-care optical imaging devices. Specific requirements: A PhD’s degree in optical instrumentation, optics and optical technology, precision instrument or related fields; Extensive experiences in optical microscopic or endoscopic system design and alignment; Experiences in designing and development of opto-mechanical systems such as an OCT endoscope; Research track records ...

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      Mentions: Nanyang Technological University Linbo Liu

    3. Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication

      Explore ScienceDirect Dentistry
      Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication

      The geometrical characteristics of dental implants, such as thread depth and width, facing angle, pitch, and surface roughness, are important to assess their stability and osseointegration after implant surgery. Herein, we demonstrate the potential use of depth-resolved swept-source optical coherence tomography (SS-OCT) to assess the structural quality of widely used dental implants. The implemented SS-OCT system was centered at a wavelength of 1300 nm with a 100 nm full-width at half-maximum. Four dental implants with different structural formations fabricated using either titanium or ceramic were visualized. Qualitative assessments were performed using boundary flattening with an amplitude-profiling algorithm to emphasize and ...

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      Mentions: Jeehyun Kim Kyungpook National University Ruchire Eranga Wijesinghe

    4. Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images

      Explore OSA | OSA Publishing Cardiology
      Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images

      Accurate identification of coronary plaque is very important for cardiologists when treating patients with advanced atherosclerosis. We developed fully-automated semantic segmentation of plaque in intravascular OCT images. We trained/tested a deep learning model on a folded, large, manually annotated clinical dataset. The sensitivities/specificities were 87.4%/89.5% and 85.1%/94.2% for pixel-wise classification of lipidous and calcified plaque, respectively. Automated clinical lesion metrics, potentially useful for treatment planning and research, compared favorably (<4%) with those derived from ground-truth labels. When we converted the results to A-line classification, they were significantly better (p < 0.05) than ...

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      Mentions: Case Western Reserve University David L. Wilson Hiram G. Bezerra

    5. Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston

      Explore Optical Coherence Tomography News Jobs & Studentships
      Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston

      The Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) in Department of Biomedical Engineering at the University of Houston, TX invites applications for one or more pre- and post-doctoral positions in the area of optical imaging, photoacoustics, and biomechanics. Extensive experience in one of the following areas is required: optical coherence tomography (OCT), opto(photo)acoustics, light-sheet microscopy (instrumentation and software development), optical elastography/biomechanics, and Brillouin Spectroscopy. The successful applicants will join dynamic team to work on projects such as optical methods to study tissue (ocular, skin, heart) biomechanics and development of advanced optical methods for developmental biology. Excellent ...

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      Mentions: Kirill V. Larin University of Houston

    6. Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Explore European Respiratory Journal Pulmonology
      Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Introduction: Differentiating ARDS from other forms of respiratory failure can be difficult. By advancing an optic fiber through a diagnostic bronchoscope, followed by an automatic pullback mechanism, OCT enables real-time 3D imaging of the alveolar compartment and peripheral airways. Aim: To investigate feasibility of bronchoscopic OCT, and to describe different OCT patterns of the alveolar compartment in mechanically ventilated patients. Methods: Observational study of OCT imaging in mechanically ventilated patients for non-resolving acute respiratory failure with an indication for diagnostic bronchoscopy. Results: 9 patients were included with clinical features of acute respiratory failure and bilateral pulmonary infiltrates not fully explained ...

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      Mentions: Daniël M. de Bruin

    7. Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

      Explore IEEE Xplore Ophthalmology
      Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

      Objective: Deep anterior lamellar keratoplasty (DALK) significantly reduces the post-transplantation morbidity in patients eligible for partial-thickness cornea grafts. The popular "big bubble" technique for DALK is so challenging, however, that a significant fraction of corneal pneumodissection attempts fail for surgeons without extensive DALK-specific experience, even with previous-generation cross-sectional optical coherence tomography (OCT) guidance. We seek to develop robotic, volumetric OCT-guided technology capable of facilitating or automating the difficult needle insertion step in DALK. Methods: Our system provides for real-time volumetric corneal imaging, segmentation, and tracking of the needle insertion to display feedback for surgeons and to generate needle insertion plans ...

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      Mentions: Joseph A. Izatt Duke University Anthony N. Kuo

    8. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Employer Description Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. Led by Guillermo ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    9. Australia’s Cylite promises the next generation OCT

      Explore Home - Insight Ophthalmology , Other Business News
      Australia’s Cylite promises the next generation OCT

      An Australian company is taking on the giants of ophthalmology with its own OCT device. LEWIS WILLIAMS looks at what the Cylite HP-OCT is doing different to set itself apart. When visiting trade displays at conferences, it is always wise to pay particular attention to the lower-key exhibits. That was certainly the case at the recent O=MEGA19 conference and trade exhibition held at Melbourne’s Convention and Exhibition Centre in July. There, on the Medmont stand, was an understated inclusion – an Australian designed and made optical coherence tomography (OCT) instrument. It is difficult to imagine a more unlikely or ...

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      Mentions: Cylite

    10. PhD Opening at Indiana University

      Explore Optical Coherence Tomography News Jobs & Studentships
      PhD Opening at Indiana University

      A PhD student position is available in Don Miller’s laboratory on advanced ophthalmic imaging at Indiana University ( www.opt.indiana.edu/dtmiller/Index.aspx ). The laboratory is looking for a highly motivated student in engineering, optical physics, or a related discipline with an interest to develop cutting-edge optical instrumentation to study noninvasively the retina at the cellular level. The laboratory’s primary focus is on the development and use of adaptive optics and optical coherence tomography, technologies the laboratory has been advancing for the past two decades. Some of our recent work can be found in PNAS: www.pnas ...

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      Mentions: Donald T. Miller Indiana University

    11. Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing

      Explore Nature Publishing Group NDE/NDT
      Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing

      Advances in microscopy have enabled us to see at unprecedented depths and resolutions, even breaking the diffraction-limit by several fold. These improvements have come at the expense of system complexity with microscopes routinely employing multiple objective lenses and custom optical relays. Optimal system design is paramount for imaging performance, but research systems are limited by the use of commercial components because optical prescriptions are often inaccessible. System performance can be further degraded when these components are implemented in nonstandard configurations outside of manufacturer specifications. Here, we describe a method for characterization of compound optical elements including curvatures, material and air-gap ...

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      Mentions: Yuankai K. Tao

    12. Intravascular Polarimetry in Patients With Coronary Artery Disease

      Explore ScienceDirect Cardiology
      Intravascular Polarimetry in Patients With Coronary Artery Disease

      Objectives The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods Thirty patients undergoing polarization-sensitive OFDI (acute coronary syndrome, n = 12; stable angina pectoris, n = 18) participated in this study. Three hundred forty-two cross-sectional images evenly distributed along all imaged coronary arteries were classified into ...

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      Mentions: Brett E. Bouma Massachusetts Institute of Technology Leiden University

    13. Researchers advance image-guided robotic surgical tools for delicate eye procedures

      Explore School of Engineering Ophthalmology
      Researchers advance image-guided robotic surgical tools for delicate eye procedures

      Molecular, gene and cell-based therapies targeting eye diseases could prevent and potentially reverse cell degeneration that leads to loss of sight. However, delivering injections safely and accurately into targeted ocular layers remain concerns that affect the advancement of life-changing new treatments. To address the safety and reliability challenges, researchers in the Vanderbilt Institute for Surgery and Engineering are joining their expertise to enable the use of optical coherence tomography (OCT) imaging for assistive robot control feedback aimed at enabling extreme precision subretinal drug delivery. Front, Mechanical Engineering Professor Nabil Simaan and Karen Joos, Joseph and Barbara Ellis Professor of Ophthalmology ...

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      Mentions: Vanderbilt University

    14. Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      A postdoctoral or research scientist position is available in Larina Lab in the Department of Molecular Physiology and Biophysics at the Baylor College of Medicine, Houston, TX to develop functional optical imaging methods toward investigation of developmental mechanisms. We are a dynamic highly collaborative team of optical engineers and biologists, investigating biomechanical aspects of biological processes in mouse models of human disorders. Our studies bring together optical system design, OCT, confocal/multiphoton microscopy, optogenetics, technology development in functional optical imaging and data processing (4D angiography, cilia beat mapping, cardiodynamic analysis, elastography), vital fluorescent reporters, genetic mouse models of human disorders ...

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      Mentions: Baylor College of Medicine Irina V. Larina

    15. Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      Explore jstage.jst.go.jp Cardiology
      Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      The microscopic tissue structure and organization influence the polarization of light. Intravascular polarimetry leverages this compelling intrinsic contrast mechanism by using polarization-sensitive optical frequency domain imaging to measure the polarization properties of the coronary arterial wall. Tissues rich in collagen and smooth muscle cells appear birefringent, while the presence of lipid causes depolarization, offering quantitative metrics related to the presence of important components of coronary atherosclerosis. Here, we review the basic principles, the interpretation of polarization signatures, and first clinical investigations of intravascular polarimetry and discuss how this extension of contemporary intravascular imaging may advance our knowledge and improve clinical ...

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      Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University

    16. 3D cellular-resolution imaging in arteries using few-mode interferometry

      Explore Nature Publishing Group
      3D cellular-resolution imaging in arteries using few-mode interferometry

      Article Open Access Published: 21 November 2019 3D cellular-resolution imaging in arteries using few-mode interferometry Biwei Yin , Zhonglie Piao , Kensuke Nishimiya , Chulho Hyun , Joseph A. Gardecki , Adam Mauskapf , Farouc A. Jaffer & Guillermo J. Tearney Light: Science & Applications volume 8 , Article number: 104 ( 2019 ) Cite this article Article metrics 3 Altmetric Metrics details Abstract Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant, as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent manner. However, due to the inherent resolution-depth of focus tradeoff of conventional focusing optics, today ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    17. Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      Explore jstage.jst.go.jp Cardiology
      Optical Technology Stepping Forward　― Utility of Intracoronary Optical Coherence Tomography ―

      I ntravascular optical coherence tomography (OCT) is a light-based imaging modality that enables detailed visualization of the intraluminal structures in coronary arteries. High-resolution (10–20μm) cross-sectional images are generated by measuring the echo time delay and intensity of light that is reflected or backscattered from the internal structures in tissues.1,2 OCT is clinically useful during percutaneous coronary intervention (PCI) to assess lesion severity, optimize stent implantation, and characterize atherosclerotic plaques, including the identification of thin-cap fibroatheroma (TCFA) and lipid-rich plaques, which are reportedly responsible for periprocedural complications. OCT can also be used to assess the mechanism for ...

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      Mentions: Toshiro Shinke

    18. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Explore IEEE Xplore Cardiology
      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between two adjoining OCT A-line datasets. By interpretation of the velocity field as measured around the zero phase shift, the flow direction at specific angles can be qualitatively estimated. Imaging experiments ...

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      Mentions: Robert A. Huber Gijs van Soest Anton F. W. van der Steen

    20. Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      Explore OSA | OSA Publishing
      Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model

      There exists an unmet need for an optical coherence tomography (OCT) delivery scheme that is simple, robust, and applicable to general surgical applications. To deliver the beam in a narrow form factor, optical borescopes present an attractive potential solution. We present a method for enabling endoscopic delivery of OCT using a handheld rigid borescope adapted to a low-cost OCT engine. The system reduces the distal profile of the scanner, enabling application of the system in otherwise hard-to-access regions. The clinical potential of this design is demonstrated through real-time quantification of articular cartilage thickness, a primary biomarker of joint health during ...

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      Mentions: Duke University Adam Wax
    21. See all articles

  2. Recent Articles From Around The Web

    1. Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Patients undergo collection of tears, saliva, buccal mucosa, and fecal samples before stem cell transplant, at 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients also undergo collection of blood samples before stem cell transplant, at 1-2, 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients may undergo skin and mouth biopsy over 15-30 minutes before stem cell transplant, at 2-3 and 12 months after stem cell transplant, and at cGVHD onset. Patients undergo digital pictures of the eyes, mouth and skin, and optical ...

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    2. Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      Explore The JAMA Network Ophthalmology
      Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation

      The advent of optical coherence tomography angiography (OCTA), a relatively new tool to image the retinal and choroidal microvasculature with depth-resolved capability, has been met with great excitement by some ophthalmologists. This noninvasive technology is a potentially valuable instrument to differentiate flow impairment in the superficial vs deep retinal capillary plexus, and it can quantify nonperfusion in eyes with retinal vascular disease. Moreover, OCTA has advanced understanding of the microvascular morphology of choroidal neovascularization and has demonstrated its various growth patterns.  It also has highlighted the potential importance of inner choroidal flow impairments associated with the development and progression of ...

      Read Full Article
      Mentions: Srinivas R. Sadda UCLA

    4. Artificial Intelligence and Healthcare: Products and Procedures

      Explore Home - Springer
      Artificial Intelligence and Healthcare: Products and Procedures

      This paper focuses on statutory regulation of learning machines that qualify as medical devices. After a brief case study, the article takes a procedural perspective and presents the main features of the European regulatory framework that applies to medical devices in order to identify the regulatory peculiarities in the use of machine learning. In this context, the Chapter will analyse the immanent risks of machine learning applications as medical devices as well as the role of machine learning in their regulation. The overall finding is that due to its lack of expertise and material equipment the state activates private companies ...

      Read Full Article

    5. Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      Explore Home - Springer Dentistry , Textbooks
      Oral Diagnosis Minimally Invasive Imaging Approaches (Textbook)

      The overall goal of this book is to provide the reader with an understanding of the new minimally invasive techniques that are available for the purpose of diagnostic imaging in dentistry and to explain their impact on clinical practice. The book concentrates very much on those techniques that are clinically applicable and useful to dentists NOW, although it also provides a fascinating view to the future. The chapters are divided according to the major clinical topics in dentistry. Each chapter provides considerable visual content, including flow charts, schematics, and photographs. The principles of the technologies presented are discussed in an ...

      Read Full Article

    6. Machine learning, imaging technique may boost colon cancer diagnosis

      Explore The Source Gastroenterology , Oncology
      Machine learning, imaging technique may boost colon cancer diagnosis

      Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal. Current colon cancer screening is performed by flexible colonoscopy. The procedure involves visual inspection of the mucosal lining of the colon and rectum with a camera mounted on an endoscope. Abnormal appearing areas are then biopsied for analysis. Although this is the current standard of ...

      Read Full Article
      Mentions: Washington University in St. Louis Quing Zhu

    7. Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Explore Nature Publishing Group Ophthalmology
      Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Background/Objectives Choroidal thinning has been suggested in Leber’s hereditary optic neuropathy (LHON). No study has been conducted of the choroid in relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought to measure choroidal thickness in chronic LHON and to correlate thickness changes with the RGC-IPL. Subjects/Methods Chronic LHON, 11778 mitochondrial DNA (mtDNA) mutation, patients (26 eyes; mean age: 35.1 ± 16.1 years) were prospectively recruited at Doheny Eye Center, University of California Los Angeles from March 2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 ± 11.1 years) were enroled ...

      Read Full Article

    8. Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Explore Karger Publishers Ophthalmology , Tunable Sources
      Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography

      Combined central retinal artery and vein occlusion is an uncommon vascular pathology that can cause severe and permanent visual impairment. Optical coherence tomography angiography (OCTA) is a newly available, noninvasive imaging technique that can potentially improve understanding of the structural and vascular implications and prognosis of this infrequent pathology. The present report describes the principal clinical findings in a case of combined central retinal artery and vein occlusion, as detected by the different imaging modalities available in a tertiary referral hospital. OCTA wide-field montage images identified an extensive area of nonperfusion on the macula with involvement of the entire retina ...

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    9. Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Explore Journals | PLOS Ophthalmology
      Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

      Optical coherence tomography angiography (OCT-A) represents the most recent modality in retinal imaging for non-invasive and depth-selective visualization of blood flow in retinal vessels. With regard to quantitative OCTA measurements for early detection of subclinical alterations, it is of great interest, which intra- and extra-ocular factors affect the results of OCTA measurements. Here, we performed OCTA imaging of the central retina in 65 eyes of 65 young healthy female and male participants and evaluated individual physical fitness levels by standard lactate diagnostic using an incremental maximal performance running test. The main finding was that OCTA measurements of the foveal avascular ...

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    10. Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      Explore The JAMA Network Ophthalmology
      Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

      At clinical conferences and in publications, use of the term real world is widespread. It describes physicians’ accumulated experience in treating patients. It is contrasted with academic trials. Randomized clinical trials differ from practice in that they have fixed prespecified inclusion and exclusion criteria, adherence to a prespecified protocol, and ideally good patient retention. Randomized clinical trials have an advantage against observational studies when comparing treatments because they largely control for confounders, bias, and chance. Patient and treatment selection bias, losses to follow-up, outcome measurement, and imaging variability as well as many other confounding and bias factors can have large ...

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      Mentions: Medical University of Vienna Ursula Schmidt-Erfurth

    11. Prevalence of dengue-related fundus and macular optical coherence tomography findings among inpatients in a regional referral hospital

      Explore Asian Journal of Ophthalmology Ophthalmology
      Prevalence of dengue-related fundus and macular optical coherence tomography findings among inpatients in a regional referral hospital

      Purpose: To investigate the prevalence of fundus and macular optical coherence tomography (OCT) findings, and the spectrum of dengue-related fundus presentation in a Malaysian tertiary hospital. The associations between platelet count and haematocrit level with fundus and macular OCT findings were also investigated. Design: Cross-sectional study. Methods: The study was conducted at Hospital Raja Permaisuri Bainun, Ipoh, from June to August 2015. Patients who consented to participate underwent a comprehensive ocular examination. Examination included a best-corrected distance (6 m) and near visual acuities, standard black-on-white Amsler chart testing, pupillary light reflex, fundus examination, followed by dilated fundus photographs and OCT ...

      Read Full Article

    13. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Explore The JAMA Network Ophthalmology
      Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a systematic literature review to assess the percentage of articles that report correcting the scale of their OCTA images for individual differences in retinal magnification. Evidence Review A PubMed (MEDLINE) search ...

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      Mentions: University of Wisconsin Joseph Carroll Fred K. Chen

    14. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      Explore Wiley::Home Dermatology , Textbooks
      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical ...

      Read Full Article
      Mentions: Nanyang Technological University Linbo Liu

    15. Monte Carlo Methods for Simulation of Optical Coherence Tomography of Turbid Media

      Explore intechopen.com
      Monte Carlo Methods for Simulation of Optical Coherence Tomography of Turbid Media

      We describe two importance sampling techniques for a standard Monte Carlo (MC) method that could enable fast simulation of signals from optical coherence tomography (OCT) imaging systems. These OCT signals are generated due to diffusive reflections from either multilayered or arbitrary shaped, turbid media, for example, tissue. Such signals typically consist of ballistic and quasi-ballistic components, of scattered photons inside the medium, in addition to photons that undergo multiple scattering. We show that MC simulation of these OCT signals using importance sampling reduces its computation time on a serial processor by up to three orders of magnitude compared to its ...

      Read Full Article
      16. See all articles
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    1. (2 articles) Johns Hopkins University
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    1. (2 articles) Linbo Liu
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    GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital Australia’s Cylite promises the next generation OCT PhD Opening at Indiana University Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing Intravascular Polarimetry in Patients With Coronary Artery Disease

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    1. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    2. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
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    3. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
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    4. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
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    5. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    6. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    7. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    8. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    9. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    10. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood