Featured Articles

1. Northeast Symposium on Biomedical Optics to be Held October 24th, 2018

   Explore Optical Coherence Tomography News 7 hours, 35 min ago

   

   On behalf of the Center for Biomedical OCT Research and Translation (CBORT) at the Wellman Center for Photomedicine, Massachusetts General Hospital, we would like to invite you to participate in the Northeast Symposium on Biomedical Optics 2018 and present your interesting work. This one-day symposium will be held on October 24th, 2018 on the MIT campus in Cambridge, MA. Lunch and coffee will be provided, and a Best Poster Award will be presented at the closing reception with food and drink. Registration is completely FREE. If you would like to participate, please register at the following link, where you will ...

   Read Full Article

   Comment

   Mentions: Massachusetts General Hospital Harvard University Jian Ren

2. Professor Andrzej Kowalczyk Celebration Gala

   Explore Optical Coherence Tomography News Sep 24 2018

   

   On September 15 th 2018, the Institute of Physics at Nicolaus Copernicus University in Toruń, Poland, held a special event to celebrate the academic achievements of Professor Andrzej Kowalczyk, on the occasion of his retirement. Professor Kowalczyk has been a great mentor, teacher, scholar and ambassador of science over his lengthy career. At the conclusion of his PhD thesis viva voce on spectroscopy, the great Jabłoński, the grandfather of fluorescence, said “Too much Chemistry, Dr Kowalczyk!” A great part of his scientific work has, indeed, been devoted to the development of spectral domain optical coherence tomography – pure optics, and his ...

   Read Full Article

   Comment

   Mentions: National Institutes of Health Adrian G. Podoleanu University of Kent

3. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

   Explore Wiley Online Library Sep 20 2018 Dermatology

   

   Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement is fundamental for tumor growth, worsening the prognosis. Dynamic Optical Coherence Tomography (D‐OCT) enables the in vivo evaluation of vascular patterns in skin lesions. Objective In vivo evaluation of the melanoma vessel morphology by means of D‐OCT and correlation with Breslow index. Methods Retrospective analysis of histologically proven melanomas, evaluated by D‐OCT at three different depths (150, 300 and 500 μm) was performed. Vessels were classified according to morphology (dots, blobs, coiled, line, curved, serpiginous), distribution (regular, irregular), and presence/type ...

   Read Full Article

   Comment

   Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen

4. Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle

   Explore OSA | OSA Publishing Sep 20 2018

   

   Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After accumulating 12 astigmatism-diverse OCT volumes, we show a 10 dB enhancement in signal-to-background ratio via a coherent average of reconstructed signals from a USAF target located 7.2 scattering mean ...

   Read Full Article

   Comment

   Mentions: Cornell University Steven G. Adie

5. High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

   Explore jstage.jst.go.jp Sep 19 2018 Probes

   

   We developed an endoscopic microscopy system with 20 nm accuracy that affords inspection through narrow gaps using a thin, 1.5 mm diameter probe. Accuracy was improved using Optical Coherence Tomography (OCT). The frequency modulated light source is stabilized with closed control from self-interference measurement. The probe is driven by two miniature motors, which allow three-dimensional scanning of an internal surface. Imaging performance is 60 frames per second. The high accuracy with narrow clearance capabilities of this system reduces the need for machine overhauls, which affords trustworthy daily inspections and hence greater machine reliability.

   Read Full Article

   Comment

6. Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz

   Explore bioRxiv.org Sep 18 2018 Ophthalmology

   

   bjective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A-scans at 1.64MHz with a center wavelength of 1063nm, and an AO subsystem providing diffraction-limited imaging. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well ...

   Read Full Article

   Comment

   Mentions: John S. Werner Robert J. Zawadzki UCSD

7. Heidelberg Engineering OCT Angiography Module Now Available in the United States

   Explore Optical Coherence Tomography News Sep 17 2018 Ophthalmology , Other Business News

   

   OCTA is a key component of the SPECTRALIS portfolio, delivering on the platform’s upgradeability and multimodal image capabilities. Heidelberg Engineering, a privately-held imaging solutions company focused on advanced diagnostic instruments and IT solutions for eye care professionals, announced today that it has received US Food and Drug Administration (FDA) clearance for its OCT Angiography Module (OCTA). The additional module is now available for new and existing SPECTRALIS® upgradeable diagnostic imaging devices. “We are excited to announce this FDA clearance as further validation not only of OCTA technology in the industry, but also of our commitment to meeting the highest ...

   Read Full Article

   Comment

   Mentions: Heidelberg Engineering Tufts University FDA

8. Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

   Explore OSA | OSA Publishing Sep 16 2018 Probes

   

   Fiber-based polarization-sensitive optical coherence tomography (PS-OCT) that utilizes a rotationally-scanning catheter has a variety of potential biomedical applications in luminal organ systems due to its ability to provide intrinsic contrast for birefringent tissue. Incorporating the optic axis (OA) of the tissue greatly enhances this potential by also permitting information about the orientation of the tissue to be extracted; however, measurement distortion that occurs has up to this point made it impossible to obtain accurate sample OA measurements. In this paper we present a straightforward calibration technique that allows the sample OA to be recovered. This technique requires no hardware modifications ...

   Read Full Article

   Comment

   Mentions: Massachusetts General Hospital Harvard University Melissa J. Suter

9. First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

   Explore Neurointervention Sep 16 2018 Cardiology , Neurology

   

   A 64-year-old female presented with an incidentally-discovered right posterior inferior cerebral artery (PICA) aneurysm, initially treated in 2015 by simple coiling. Follow-up demonstrated significant coil compaction that required retreatment. Retreatment was done uneventfully using a Pipeline embolization device (PED) shield deployed starting from the basilar artery and ending at the V4 segment of the vertebral artery. Eight-weeks post-deployment, a follow-up digital subtraction imaging (DSA) and intravascular imaging with optical coherence tomography were obtained. The intravascular imaging demonstrated that the flow diverter had good wall apposition and concentric neointimal growth over the braid with exception to the areas that the PED ...

   Read Full Article

   Comment

   Mentions: St. Jude Medical

10. Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia

    Explore Home - ClinicalTrials.gov Sep 13 2018 Gastroenterology , Clinical Trials

    

    Patients with Barrett's Esophagus (BE) undergoing endoscopic therapy through our Barrett's Esophagus Unit will be approached for study enrollment. Patients with no endoscopic evidence of BE will be considered for the study. Surveillance biopsies will be obtained per standard clinical protocol and reviewed to confirm absence of intestinal metaplasia. Patients who have achieved complete eradication of intestinal metaplasia (CRIM) will be enrolled in the study and will undergo the Nvision® Imaging System (VLE). Patients enrolled in the study will undergo clinical follow-up consisting of surveillance endoscopy every 3 months for 1 year. Surveillance endoscopy intervals may be prolonged ...

    Read Full Article

    Comment

    Mentions: NinePoint Medical

11. OCT Promising as Clear Point-of-Care Solution

    Explore Photonics.com Sep 12 2018

    

    Medical devices at the point of care allow clinicians to do what they do best: determine a patient’s exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a steep learning curve or worry about the underlying scientific principles, and without the high cost seen for so many medical technologies. Optical coherence tomography (OCT) is an imaging technology that has become well-known in recent years for its proven diagnostic ability, particularly in the eye care realm. This technology is now the gold standard for diagnosing eye diseases such as ...

    Read Full Article

    Comment

    Mentions: Duke University Adam Wax

12. First workshop on artificial intelligence applied to retinal image analysis, Perth Australia, December 2018.

    Explore Philippe Burlina Sep 12 2018 Ophthalmology

    

    Medical imaging has now embraced AI methods based on deep learning (DL) approaches for medical image analytics. This has been especially true for retinal image analysis where large annotated datasets have been available for over 10 years. Recent studies starting in 2016 have demonstrated on par with human performance for diagnostic tasks such as screening for diabetic retinopathy and macular degeneration. Recently, in 2018, the FDA approved the first software device for retinal diagnostics. The goal of this workshop is to showcase recent developments in AI for retinal image analysis and as a follow up on recent meetings at ARVO ...

    Read Full Article

    Comment

    Mentions: FDA Delia Cabrera DeBuc

13. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

    Explore Optical Coherence Tomography News Sep 8 2018 Jobs & Studentships

    

    A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on interdisciplinary projects in the field of optical imaging and real-time image processing. Ph.D. in Optics, Biomedical Engineering, Electrical Engineering, Computer Science or a related field is required. Demonstrated excellence in one or more of the following areas is required: expertise in optical coherence Tomography, scanning laser ophthalmoscope and adaptive optics, optical/electrical system design, prototyping and simulation, data acquisition and system control/synchronization, and C++/GPU ...

    Read Full Article

    Comment

    Mentions: David Huang Oregon Health & Science University Center for Ophthalmic Optics and Lasers

14. Simple approach for aberration-corrected OCT imaging of the human retina

    Explore OSA | OSA Publishing Sep 7 2018 Ophthalmology

    

    Aberration-corrected imaging of human photoreceptor cells, whether hardware or software based, presently requires a complex and expensive setup. Here we use a simple and inexpensive off-axis full-field time-domain optical coherence tomography (OCT) approach to acquire volumetric data of an in vivo human retina. Full volumetric data are recorded in 1.3 s. After computationally correcting for aberrations, single photoreceptor cells were visualized. In addition, the numerical correction of ametropia is demonstrated. Our implementation of full-field optical coherence tomography combines a low technical complexity with the possibility for computational image correction.

    Read Full Article

    Comment

    Mentions: Gereon Hüttmann Reginald Birngruber University of Lübeck

15. NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering

    Explore nibib.nih.gov Sep 7 2018

    

    National Institutes of Health Director Francis S. Collins, M.D., Ph.D., has selected Bruce J. Tromberg, Ph.D., as director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). A pioneering leader in the field of bio photonics, Dr. Tromberg is currently a professor at the University of California at Irvine (UCI), with dual appointments in the Departments of Biomedical Engineering and Surgery. He is also director of UCI’s Beckman Laser Institute and Medical Clinic, an interdisciplinary research, teaching and clinical center for optics and photonics in biology and medicine. He is expected to join NIH in ...

    Read Full Article

    Comment

    Mentions: National Cancer Institute National Institutes of Health Vanderbilt University

16. Clinical and surgical implications of intraoperative optical coherence tomography imaging for benign pediatric vocal fold lesions

    Explore ScienceDirect Sep 6 2018 Otolaryngology

    

    Introduction Benign vocal disorders in children include an extensive list of abnormalities creating a variety of debilitating levels of dysphonia. Precise delineation of the benign lesion type and margins may have significant public health implications in children. An innovative technology such as optical coherence tomography (OCT) is being explored to delineate pediatric benign laryngeal lesions. An accurate assessment of the subepithelial morphology may help towards tailoring more personalized therapeutic treatments. This study was established to highlight key morphological and optical features of benign pediatric laryngeal lesions using intraoperative OCT and to suggest clinical implications that arise from such optical imaging ...

    Read Full Article

    Comment

    Mentions: Harvard University Massachusetts Eye and Ear Infirmary

17. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

    Explore OSA | OSA Publishing Sep 6 2018 Probes

    

    We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in ...

    Read Full Article

    Comment

    Mentions: Robert A. Huber Gereon Hüttmann University of Lübeck

18. Watching an embryo's neural tube close

    Explore EurekAlert! Sep 4 2018 Developmental Biology

    

    In those precious weeks before a woman even realizes she's pregnant, an embryo will have already developed a neural tube, a hollow structure made of cells which will eventually become the brain and spinal cord. Now, with $3.2 million from the National Institutes of Health, UH professor of biomedical engineering Kirill Larin will tackle the evolutionary anomaly of why the neural tube closes in most embryos but remains open in others, leading to birth defects such as spina bifida and anencephaly. Neural Tube Defects (NTD) are the second most common structural birth defect in humans, affecting upwards of ...

    Read Full Article

    Comment

    Mentions: University of Maryland National Institutes of Health Baylor College of Medicine

19. Dr. Philip J. Rosenfeld to give Jackson Memorial Lecture at Opening Session of AAO 2018

    Explore American Academy of Ophthalmology Sep 1 2018 Ophthalmology

    

    Dr. Philip J. Rosenfeld is currently Director and Professor of Ophthalmology at the Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine. His primary clinical and research interests are in age-related macular degeneration (AMD). He is at the forefront of medical science having spent decades seeking effective therapies for AMD as the principal investigator and study chairman for numerous AMD clinical trials. He was instrumental in the clinical development of anti-VEGF therapies, the use of optical coherence tomography (OCT) guided treatment regimens using anti-VEGF therapy, the clinical development of OCT instruments, and the development and use of novel ...

    Read Full Article

    Comment

    Mentions: Philip J. Rosenfeld University of Miami

20. Using Optical Coherence Tomography to Reveal the Hidden History of The Landsdowne Virgin of the Yarnwinder by Leonardo da Vinci and Studio

    Explore Wiley Online Library Mar 7 2018 Art

    

    Optical coherence tomography (OCT) was used for non‐invasive examination of a well‐known, yet complex, painting from the studio of Leonardo da Vinci in combination with routine imaging in various bands of electromagnetic radiation. In contrast with these techniques, OCT provides depth‐resolved information. Three post‐processing modalities were explored: cross‐sectional views, maps of scattering from given depths, and their 3D models. Some hidden alterations of the painting owing to past restorations were traced: retouching and overpainting with their positioning within varnish layers as well as indications of a former transfer to canvas.

    Read Full Article

    Comment

    Mentions: Nicolaus Copernicus University Piotr Targowski Marcin Sylwestrzak
21. See all articles