1. Featured Articles

    1. Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries

      Explore Optica Publishing Group
      Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries

      Photothermal optical coherence tomography (PT-OCT) is a functional extension of OCT with the ability to generate qualitative maps of molecular absorptions co-registered with the micron-resolution structural tomograms of OCT. Obtaining refined insight into chemical information from PT-OCT images, however, requires solid understanding of the multifactorial physics behind generation of PT-OCT signals and their dependence on system and sample parameters. Such understanding is needed to decouple the various physical effects involved in the PT-OCT signal to obtain more accurate insight into sample composition. In this work, we propose an analytical model that considers the opto-thermo-mechanical properties of multi-layered samples in 3-D ...

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      Mentions: Massachusetts General Hospital Harvard University York University

    2. Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Explore Nature Publishing Group Oncology
      Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and tumour response kinetics. Pancreatic human tumour xenografts were thus irradiated with single doses of 10 10 , 20 20 and 30 30 Gy to simulate the first fraction of a SBRT ...

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      Mentions: University of Toronto National Research Council Canada

    3. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography

      Explore IEEE Xplore Neurology
      Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography

      Objective: Serial sectioning optical coherence tomography (OCT) enables distortion-free volumetric reconstruction of several cubic centimeters of human brain samples. We aimed to identify anatomical features of the ex vivo human brain, such as intraparenchymal blood vessels and axonal fiber bundles, from the OCT data in 3D, using intrinsic optical contrast. Methods: We developed an automatic processing pipeline to enable characterization of the intraparenchymal microvascular network in human brain samples. Results: We demonstrated the automatic extraction of the vessels down to a 20 m in diameter using a filtering strategy followed by a graphing representation and characterization of the geometrical properties ...

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      Mentions: Massachusetts General Hospital Boston University The Chinese University of Hong Kong

    4. Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography

      Explore Welcome! NDE/NDT
      Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography

      The morphological changes of anthracnose (fungus) -infected tomato seeds have been studied to identify the infection and characterize its effect. Full-field optical coherence tomography (FF-OCT) has been utilized as a nondestructive but efficient modality for visualizing the effects of fungal infection. The cross-sectional images extracted from a stack of en face FF-OCT images showed significant changes with infection in the seed structure. First of all, the seed coat disappeared with the infection. The thickness of the seed coat of a healthy seed was measured as 28.2 ㎛, with a standard deviation of 1.2 ㎛. However, for infected seeds the gap ...

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      Mentions: Gwangju Institute of Science and Technology

    5. Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland

      The Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology at the University of Maryland School of Medicine is recruiting for a highly qualified postdoctoral researcher to perform clinical research related to the use of adaptive optics (AO) techniques as applied to optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO). These techniques allow visualization of the living human retina at the level of single cells. The laboratory of Dr. Daniel Harrison at the University of Maryland is collaborating with the laboratories of Drs. Zhuolin Liu and Daniel X. Hammer at the Food and Drug Administration (FDA) to perform clinically ...

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      Mentions: University of Maryland FDA

    6. Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

      Explore Optica Publishing Group Oncology
      Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

      We demonstrate a convolutional neural network (CNN) for multi-class breast tissue classification as adipose tissue, benign dense tissue, or malignant tissue, using multi-channel optical coherence tomography (OCT) and attenuation images, and a novel Matthews correlation coefficient (MCC)-based loss function that correlates more strongly with performance metrics than the commonly used cross-entropy loss. We hypothesized that using multi-channel images would increase tumor detection performance compared to using OCT alone. 5,804 images from 29 patients were used to fine-tune a pre-trained ResNet-18 network. Adding attenuation images to OCT images yields statistically significant improvements in several performance metrics, including benign dense ...

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      Mentions: Thorlabs University of Western Australia OncoRes Medical

    7. Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon

      Explore Home | AHA/ASA Journals Cardiology
      Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon

      Intravascular ultrasound (IVUS) or optical coherence tomography provides superior information to coronary angiography, including cross-sectional true vessel size, amount of calcification, distribution of plaque to inform stent landing zone, stent expansion, and stent edge dissection or uncovered disease, which have been well known as key metrics in percutaneous coronary intervention avoiding future stent failure. 1 Complex lesion morphology is typically defined as an unprotected left main lesion, severely calcified lesion, long lesion, bifurcation lesion, chronic total occlusion, or in-stent restenosis in which optimal percutaneous coronary intervention is far more difficult than other lesions. 2-4 Thus, they have a greater chance ...

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      Mentions: Columbia University

    8. Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation

      Explore Optical Coherence Tomography News Jobs & Studentships
      Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation

      We are seeking a Research Scientist for Optical Diagnostics to be part of an innovative research team, based in Rochester, NY, with the mission of developing new optical technologies for improving measurement and diagnosis in dentistry. We are a part of DEXIS, an Envista company. Dental professionals have known the DEXIS brand as the leader in digital intraoral radiography and diagnostic software innovation for over 20 years. DEXIS products represent a full portfolio of award-winning imaging and digital solutions including cone-beam computed tomography (CBCT), handheld x-rays, intraoral scanners, sensors, and navigated surgical solutions. With one of the largest installed bases ...

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    9. Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band

      Explore Optica Publishing Group
      Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band

      Ultrahigh resolution optical coherence tomography (UHR-OCT) can image microscopic features that are not visible with the standard OCT resolution of 5-15 µm. In previous studies, high-speed UHR-OCT has been accomplished within the visible (VIS) and near-infrared (NIR-I) spectral ranges, specifically within 550-950 nm. Here, we present a spectral domain UHR-OCT system operating in a short-wavelength infrared (SWIR) range from 1000 to 1600 nm using a supercontinuum light source and an InGaAs-based spectrometer. We obtained an axial resolution of 2.6 µm in air, the highest ever recorded in the SWIR window to our knowledge, with deeper penetration into tissues than ...

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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University

    10. Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Explore Optica Publishing Group Otolaryngology
      Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Optical coherence tomography (OCT) has become an important tool for measuring the vibratory response of the living cochlea. It stands alone in its capacity to measure the intricate motion of the hearing organ through the surrounding otic capsule bone. Nevertheless, as an extension of phase-sensitive OCT, it is only capable of measuring motion along the optical axis. Hence, measurements are 1-D. To overcome this limitation and provide a measure of the 3-D vector of motion in the cochlea, we developed an OCT system with three sample arms in a single interferometer. Taking advantage of the long coherence length of our ...

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      Mentions: Texas A&M University UCLA

    11. Fiber-laser platform for precision brain surgery

      Explore Optica Publishing Group Neurology
      Fiber-laser platform for precision brain surgery

      Minimally invasive neurological surgeries are increasingly being sought after for treatment in neurological pathologies and oncology. A critical limitation in these minimally invasive procedures is lack of specialized tools that allow for space-time controlled delivery of sufficient energy for coagulation and cutting of tissue. Advent of fiber-lasers provide high average power with improved beam quality (lower M 2 ), biocompatible silica fiber delivery, reduced cost of manufacturing, and radiant output stability over long operating periods. Despite these advancements, no fiber-laser based surgical tools are currently available for tissue resection in vivo . Here we demonstrate a first to our knowledge, fiber-laser platform ...

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    12. Registration of histological brain images onto optical coherence tomography images based on shape information

      Explore IOPscience Neurology
      Registration of histological brain images onto optical coherence tomography images based on shape information

      Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far requires histological analysis of biopsies taken from at expected tumour boundaries. The gold standard for histological analysis is the staining of thin cut specimen and the evaluation by a neuropathologist. This work presents a way to transfer the histological evaluation of a neuropathologist onto optical coherence tomography (OCT) images. OCT is a method suitable for real time in vivo imaging during neurosurgery however ...

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      Mentions: University of Lübeck

    13. Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways

      Explore Optica Publishing Group Pulmonology
      Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways

      In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences of microscopic resolution OCT (mOCT) images, OCT can use small signal fluctuations to overcome lack in contrast and speckle noise. In this way, OCT visualizes airway morphology on a cellular level and allows the tracking of the dynamic behavior of immune cells, as well as mucus transport and secretion. Here, we demonstrate that mOCT, by using temporal tissue fluctuation as contrast (dynamic mOCT), provides ...

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      Mentions: Thorlabs e2v University of Lübeck

    14. Linewidth considerations for MEMS tunable VCSEL LiDAR

      Explore Optica Publishing Group Tunable Sources
      Linewidth considerations for MEMS tunable VCSEL LiDAR

      The flexible membranes used in MEMS tunable VCSELs are so small and light that thermally induced vibrations can impact laser performance. We measure the thermal vibration spectrum of such a membrane showing peaks at the spatial vibration mode resonant frequencies of the membrane/plate. These vibrations result in a theoretical floor to the linewidth of the VCSEL. Frequency domain LiDAR and optical coherence tomography systems can get around this thermal linewidth limit with adequate clock measurement and processing. Essentially an OCT/LiDAR sweep with a concomitantly measured clock is a feed-forward linewidth reduction scheme. This can be achieved because the ...

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      Mentions: Axsun Technologies

    15. Laboratory system for optical coherence tomography (OCT) using a laser plasma source of soft x-rays and extreme ultraviolet and focusing ellipsoidal optics

      Explore Optica Publishing Group
      Laboratory system for optical coherence tomography (OCT) using a laser plasma source of soft x-rays and extreme ultraviolet and focusing ellipsoidal optics

      Optical coherence tomography (OCT) with the use of soft x-rays (SXR) and extreme ultraviolet (EUV) has been recently demonstrated [Fuchs et al. Sci. Rep.6, 20658 (2016)10.1038/srep20658; Fuchs et al. Optica4, 903 (2017)10.1364/OPTICA.4.000903]. This new imaging technique, named XCT, makes it possible to obtain cross-sectional and tomographic images of objects with nanometer spatial resolution. The article presents a newly developed laboratory system for XCT using a compact laser plasma light source operating in the SXR and EUV spectral ranges. The source is based on a gas puff target containing Kr gas or ...

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    16. Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice

      Explore ane.pl Neurology
      Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice

      We demonstrate in vivo imaging of the ischemic area in the mouse brain after photostroke using a custom prototype Gaussian‑beam optical coherence tomography (OCT) setup in which the near infrared imaging beam and the green photoinducing light pass through the same objective lens. The goal of our research was analysis of vascularity of the ischemic area during 2‑week progress of stroke and correlating the hypo‑ and hyperreflective OCT scattering areas with the location of activated microglia and astroglia. Angiogenesis, which was assessed using angiomaps, showed that the area of vessels in the ischemic center increased until day 7 ...

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    17. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Explore Nature Publishing Group Cardiology
      Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in the management of patients with acute coronary syndromes. Detection by OCT of healed coronary plaque has been important in our understanding of the mechanisms involved in plaque destabilization and healing ...

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      Mentions: Brigham and Women’s Hospital Johns Hopkins University Massachusetts Institute of Technology

    18. Coherent Optical Detection of Middle Ear Disease

      Explore Home - ClinicalTrials.gov Otolaryngology , Clinical Trials
      Coherent Optical Detection of Middle Ear Disease

      Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States, affects 90% of all children, and is the most common indication for antimicrobial therapy and surgery in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity. OM continues as the most common cause of hearing loss in children and leads to speech, educational and other developmental delays. OM causes life-threatening complications and is expensive, resulting in over $5 billion annually in U.S. health care expenditures. Despite the ...

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      Mentions: University of Wisconsin National Institutes of Health University of Illinois at Urbana-Champaign

    19. Uncover scientific innovations with Heidelberg Engineering at ARVO 2022

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Uncover scientific innovations with Heidelberg Engineering at ARVO 2022

      Heidelberg Engineering presents various scientific innovations at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) Heidelberg Engineering showcases its research capabilities at this year’s ARVO congress that takes place in Denver, Colorado, USA, from May 1–4. The team looks forward to reconnecting with the global research community after two years of solely virtual ARVO meetings, and to demonstrating various scientific innovations and state-of-the-art technologies at the Heidelberg Engineering booth (#2412). The research technologies shown cover a wide range of applications – from retina diagnostics and glaucoma research, cellular and metabolic imaging, to anterior segment ...

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      Mentions: Heidelberg Engineering

    20. Digital Angiography Reading Center (DARC)/WorldCare Clinical Adds Voxeleron To Analysis Pipeline

      Explore Optical Coherence Tomography News Other Business News
      Digital Angiography Reading Center (DARC)/WorldCare Clinical Adds Voxeleron To Analysis Pipeline

      DARC Continues Investment in Best-in-Class Ophthalmology Service with Orion™ by Voxeleron OCT Image Analysis Software Voxeleron, a cloud-based platform provider that analyzes and tracks all formats of ophthalmic data, announced today that Digital Angiography Reading Center (DARC) / WorldCare Clinical has selected Orion by Voxeleron for use in image analysis. Orion is a vendor-neutral platform that analyzes OCT images from multiple devices within a common platform, significantly consolidating and minimizing the reading center’s requirements for software and devices. Orion's automated centration and segmentation software, including unique editing features, offer increased accuracy with an intuitive interface to reduce errors while ...

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      Mentions: Voxeleron
    21. See all articles

  2. Recent Articles From Around The Web

    1. Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Explore ScienceDirect Ophthalmology
      Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Objective: To describe the normative quantitative parameters of macular retinal vasculature and their systemic and ocular associations, using optical coherence tomography angiography (OCTA). Design: Population based cross sectional study SUBJECTS: Adults above 50 years old were recruited from the third examination of the population-based Singapore Malay Eye Study. Methods: All participants underwent standardized comprehensive examination and Spectral domain-OCTA (Optovue, USA) of the macula. OCTA scans with pre-existing retinal disease, macular pathology, and poor quality were excluded. Main outcome measures: Normative quantitative vessel densities of the superficial, deep layer and foveal avascular zone were evaluated. Ocular and systemic associations with macular ...

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      Mentions: Visionix Singapore Eye Research Institute National University of Singapore

    2. Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning

      Explore Home - Springer Ophthalmology
      Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning

      Automatic segmentation and measurement of the choroid layer is useful in studying of related fundus diseases, such as diabetic retinopathy and high myopia. However, most algorithms are not helpful for choroid layer segmentation due to its blurred boundaries and complex gradients. Therefore, this paper aimed to propose a novel choroid segmentation method that combines image enhancement and attention-based dense (AD) U-Net network. The choroidal images obtained from optical coherence tomography (OCT) are pre-enhanced by algorithms that include flattening, filtering, and exponential and linear enhancement to reduce choroid-independent information. Experimental results obtained from 800 OCT B-scans of the choroid layers from ...

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    3. In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

      Explore Light: Advanced Manufacturing NDE/NDT
      In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

      A line-shaped beam is useful for increasing the processing speed in laser grooving and scribing. In laser grooving, depth control of the processed structure is important for performing precise processing. In this paper, in-process monitoring of the depth of a structure formed by femtosecond laser processing with a line-shaped beam using swept-source optical coherence tomography (SS-OCT) was demonstrated. In the evaluation of the SS-OCT system, the depth resolution, measurement accuracy, and axial measurable range were 15.8 μm, ±2.5 μm and 5.3 mm, respectively. In laser grooving, the structural shape and the distribution of deposited debris were successfully ...

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      Mentions: Hamamatsu Photonics

    4. The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma

      Explore Springer US Ophthalmology
      The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma

      Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG. Methods: In this cross-sectional study, 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation ...

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    5. OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment

      Explore SAGE Journals Ophthalmology
      OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment

      Purpose To propose optical coherence tomography angiography (OCT-A) for the follow-up of neovascular age-related macular degeneration (nAMD) treated with a treat-and-extend (T&E) aflibercept regimen to avoid overtreatment. Methods Retrospective, cohort, pilot study. We analysed 16 consecutive-treatment naïve nAMD eyes following up 2-years at the Eye Clinic, Bari, Italy. Intravitreal aflibercept injections in the T&E regimen for no less than 12 months, during which the macula was dry without any sign of intraretinal or subretinal fluid (SRF) at each visit, were performed. Parametric data were evaluated using an analysis of variance (ANOVA); any non-parametric statistical calculations were performed ...

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    6. A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer

      Explore Welcome to Bentham Science Publishers
      A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer

      Malignancy is one of the consequent driving explanations behind death worldwide, and it is assessed at 9.6 million in 2018. Around 1 out of 6 deaths are the direct result of the malignancy. Clinicians state, that age and breast density are two natural elements resulting in the danger of cancer. The mortality rate brought about by malignant growth in low and focus pay countries is, for the most part, around 70%. Imaging techniques play a vital role in detection, staging, and help in guiding treatment decisions. This review paper presents a comprehensive survey involving a literature study about the ...

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    7. Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System

      Explore StreetInsider.com
      Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System

      Cogmedix, a wholly-owned subsidiary of Coghlin Companies, Inc., and provider of FDA -compliant medical device engineering and manufacturing services, is proud to share that longtime customer, Seno Medical Instruments, Inc., has been selected as a GOLD winner for the 2022 Medical Device Excellence Awards in the Radiological, Imaging, and Electromechanical Devices category. This premier award program recognizes medical device companies that have demonstrated outstanding achievement and their contributions to improving the quality of healthcare worldwide. The Imagio� Breast Imaging System Seno Medical, a pioneer in the development of opto-acoustic ultrasound technology, was awarded this prestigious honor for their Imagio® Breast ...

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      Mentions: FDA Seno Medical

    8. Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Explore TVST Journal Ophthalmology
      Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Purpose: To compare various displacement models using midget retinal ganglion cell to cone (mRGC:C) ratios and to determine viability of estimating RGC counts from optical coherence tomography (OCT)-derived ganglion cell-inner plexiform layer (GCIPL) measurements. Methods: Four Drasdo model variations were applied to macular visual field (VF) stimulus locations: (1) using meridian-specific Henle fiber length along the stimulus circumference; (2) using meridian-specific differences in RGC receptive field and counts along the stimulus circumference; (3) per method (2), averaged across principal meridians; and (4) per method (3), with the stimulus center displaced only. The Sjöstrand model was applied (5 ...

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    9. Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography

      Explore ScienceDirect Ophthalmology
      Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography

      Purpose: To evaluate changes in macular blood flow in patients with various stages of diabetic retinopathy (DR) by optical coherence tomography angiography (OCTA). Materials and methods: The data of 94 patients (122 eyes) with type 2 diabetes mellitus admitted from January 2018 to May 2021 were recorded, including 31 patients (42 eyes) with no DR (NDR group), 33 patients (40 eyes) with mild non-proliferative DR (mild NPDR group) and 30 patients (40 eyes) with moderate NPDR (moderate NPDR group). Forty healthy patients (40 eyes) who were examined during the same period were selected as control group. The blood flow densities ...

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    10. Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2

      Explore Elsevier Cardiology
      Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2

      A 50-year-old male was admitted to our hospital with sudden-onset chest pain. He was a current smoker with severe obesity and diabetes. He had a history of drug-eluting stent (DES) implantation in the left anterior descending artery (LAD) and had continuously taken clopidogrel. Eight days prior to admission, polymerase chain reaction testing confirmed that he was positive for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Emergent coronary angiography revealed total occlusion of previously implanted DES in LAD. Optical coherence tomography (OCT) images demonstrated the presence of large white thrombus within the well-expanded DES with homogenous neointima. There were no ...

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      Mentions: Kitasato University

    11. Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement

      Explore Elsevier Ophthalmology
      Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement

      Purpose: Acute idiopathic blind spot enlargement is a rare syndrome that is classified within a spectrum of primary inflammatory choriocapillaropathies with circumscribed outer retinal dysfunction. Observations: We observed coarsening of the choriocapillaris on en-face optical coherence tomography angiography when compared to the fellow eye in a patient with suspected acute idiopathic blind spot enlargement. Conclusions and importance: Increased granularity of the choriocapillaris as imaged by optical coherence tomography angiography may assist in the diagnosis of acute idiopathic blind spot enlargement, particularly during a global pandemic when access to electrodiagnostics is limited. This finding supports the current evidence of choriocapillaris hypoperfusion ...

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    12. Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging

      Explore Frontiers Ophthalmology
      Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging

      Purpose: This study aimed to investigate anatomic relationships and biomechanics of pressure-dependent trabecular meshwork and distal valve-like structure deformation in normal and glaucoma eyes using high-resolution optical coherence tomography (HR-OCT). Methods: We controlled Schlemm's canal (SC) pressure during imaging with HR-OCT in segments of three normal (NL) and five glaucomatous (GL) ex vivo eyes. The dissected limbal wedges were studied from 15 locations (5 NL and 10 GL). A minimally invasive glaucoma surgery (MIGS)-like cannula was inserted into the SC lumen, whereas the other end was attached to a switch between two reservoirs, one at 0, the other ...

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      Mentions: Duke University University of Washington Indiana University

    13. Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy

      Explore Frontiers Cardiology
      Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy

      Objectives: Cervical radiotherapy can lead to accelerated carotid artery stenosis, increased incidence of stroke, and a higher rate of in-stent restenosis in irradiated patients. Our objective was to reveal the morphological characteristics of radiation-induced carotid stenosis (RICS) and the stent-vessel interactions in patients with previous cervical radiotherapy by optical coherence tomography (OCT). Materials and methods: Between November 2017 and March 2019, five patients with a history of cervical radiotherapy were diagnosed with severe carotid artery stenosis and underwent carotid artery stenting (CAS). OCT was conducted before and immediately after the carotid stent implantation. Two patients received OCT evaluation of carotid ...

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    14. The Effect of Radiologically Isolated Syndrome on Retinal and Choroidal Hemodynamics - An Optical Coherence Tomography Angiography Study

      Explore Taylor & Francis Online Ophthalmology
      The Effect of Radiologically Isolated Syndrome on Retinal and Choroidal Hemodynamics - An Optical Coherence Tomography Angiography Study

      Purpose: To evaluate vessel density of retinal plexuses and optic nerve head (ONH) and flow of choriocapillaris to detect possible subclinical retinal microvascular changes associated with the radiologically isolated syndrome (RIS). Materials and Methods: We analyzed 26 eyes of 26 participants diagnosed with RIS and 39 age and sex-matched healthy controls in this prospective, cross-sectional study. The superficial (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) parameters, the flow area of choriocapillaris were evaluated using optical coherence tomography angiography (OCTA). Results: Vessel density (VD) of the parafovea (p = 0.045) and parafoveal subregions (p = 0.049 for superior ...

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    15. The missing link in the recognition of corneal abnormalities

      Explore Ophthalmology Times Europe Ophthalmology
      The missing link in the recognition of corneal abnormalities

      Polarisation-sensitive optical coherence tomography (PS-OCT) is a functional extension of the conventional form of OCT and exploits the polarisation properties of light. According to Dr Ritika Mullick, a fellow in Cornea and Refractive Services at Narayana Nethralaya Hospital, Bangalore, India, this imaging modality can aid the early recognition of disease-related changes before they can be seen topographically. Dr Mullick explained that the human eye is known to have polarisation-altering tissues; using an ultra-high-resolution PS-OCT helps us to study the form birefringence caused by the underlying fibril structures in the corneal stroma. This, in turn, can enable users to detect subnormal ...

      Read Full Article
      16. See all articles
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    Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system Fiber-laser platform for precision brain surgery Registration of histological brain images onto optical coherence tomography images based on shape information

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