1. Feature Of The Week: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

    This work is the result of a collaboration between researchers from Professor Caroline Boudoux’s team from Polytechnique Montréal (Canada) and Professor Brett E. Bouma’s team at the Wellman Center for Photomedicine (MGH, Boston). The goal is to assess whether OCT-guided biopsy could benefit from the use of double-clad fiber (DCF). DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light used for laser marking. DCF is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and co-registered optical coherence tomography (OCT) and laser tissue coagulation.

    We designed and built a novel DCFC to combine both signals within a DCF (>90% of single-mode transmission; >65% multimode coupling). Potential OCT imaging degradation mechanisms were also investigated and solutions to mitigate them are presented in this paper. The combined DCFC-based system was used to induce coagulation of ex vivo swine esophagus samples allowing a real-time assessment of thermal dynamic processes. We therefore demonstrate a DCFC-based system combining OCT imaging with laser coagulation through a single fiber, thus enabling both modalities to be performed simultaneously and in a co-registered manner. Such a system enables endoscopic image-guided laser marking of superficial epithelial tissues or laser thermal therapy of epithelial lesions in pathologies such as Barrett’s esophagus.

    For more information see recent Article. Courtesy of Kathy Beaudette from Polytechnique Montreal. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Atherosclerosis and General Principles of Arterial Imaging

      Atherosclerosis and General Principles of Arterial Imaging

      The imaging of large arteries has expanded during recent years, both for clinical purposes and for research. The technical development has been very impressive. By the use of these modern technologies, it has been possible to achieve a better understanding of atherosclerosis and its morphology and mechanical interactions with the bloodstream. In addition, the imaging of large arteries, especially the aorta, has shed new light on the development of the changes in the arterial media linked to arterial stiffness, increased pulse wave velocity and arterial ageing. In this chapter, these aspects are discussed for atherosclerosis in general and for the ...

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    2. Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech an medical company in China established in 1999 is developing a SS-OCT endoscopic system. The system was shown at DDW 2015 and was developed by Jiefeng Xi a Principle Engineer at Micro-Tech and former PhD student at Johns Hopkins who graduated in July 2014. For more information click HERE .

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    3. University of Alabama Receives NIH Grant for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives NIH Grant  for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives a 2015 NIH Grant for $193,380 for Developing a Clinical and Translation Core related to Cystic Fibrosis. The principal investigator is steven Rowe. The program began in 2015 and ends in 2016. Below is a summary of the proposed work. Numerous investigators within the current P30 application have indicated a need for 1) primary human airway epithelial cells (from lung transplantation) or nasal epithelial cells from CF and non-CF individuals; 2) measurements of the functional anatomy of respiratory epithelia that track airway surface liquid homeostasis, ciliary beating, and mucociliary transport; or 3) CFTR bioelectric assays ...

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    4. University of Maryland Receives NIH Grant for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds

      University of Maryland Receives NIH Grant for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds

      University of Maryland Receives a 2015 NIH Grant for $320.744 for Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds. The principal investigator is Yu Chen. Below is a summary of the propose work. Three-dimensional (3D) cell-based tissue grafts have been increasingly useful in tissue engineering and regenerative medicine. A critical building block in tissue engineering is the scaffold which can act as the supporting medium to deliver cell populations and induce the ingrowth of vessels and surrounding tissues. Therefore, it is necessary to develop tools to characterize the architecture of the scaffold. In addition, to study ...

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    5. Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Superior segmental optic nerve hypoplasia (SSOH) is a congenital anomaly of the optic nerve that is commonly misdiagnosed as normal tension glaucoma (NTG) and/or juvenile open angle glaucoma (JOAG). We demonstrate the utility of SD-OCT in assessing the structure-function correlation when differentiating between SSOH and JOAG.

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    6. The Different Characteristics of Cirrus Optical Coherence Tomography between Superior Segmental Optic Hypoplasia and Normal Tension Glaucoma with Superior Retinal Nerve Fiber Defect

      The Different Characteristics of Cirrus Optical Coherence Tomography between Superior Segmental Optic Hypoplasia and Normal Tension Glaucoma with Superior Retinal Nerve Fiber Defect

      Purpose. To evaluate the different characteristics in superior segmental optic hypoplasia (SSOH) and normal tension glaucoma (NTG)with superior retinal nerve fiber layer (RNFL) defect (NTG-SRD) compared to normal control using cirrus optical coherence tomography (OCT). Methods. SSOH eyes and NTG-SRD eyes were reviewed. The peripapillary RNFL (pRNFL) and ganglion cell inner plexiform layer (GCIPL) of the two groups were compared to age-matched normal controls using cirrus OCT. Results. Included in this studywere 31 SSOH eyes, 33NTGpatients, and 49 healthy normal controls. Compared to normal controls, pRNFL thickness in SSOH eyes was thinner except in the inferotemporal to the temporal ...

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    7. The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography

      The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography

      Purpose: To assess intra- and subretinal fluid during the loading phase with intravitreal ranibizumab in exudative age-related macular degeneration and to quantify the accuracy of crosshair scan spectral-domain optical coherence tomography with regard to retinal fluid. Methods: This is a retrospective study of 31 treatment-naive patients who received 3 monthly intravitreal ranibizumab injections. Visual acuity and the presence of retinal fluid were assessed at each visit using volume and crosshair scan protocols. Results: Visual acuity improved and central retinal thickness decreased significantly during the loading phase. However, retinal fluid persisted in two thirds of the patients. The accuracy of the ...

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    8. Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      We evaluated the three-dimensional vascular architecture of feeder vessels in exudative macular disease. A case of polypoidal choroidal vasculopathy with choroidal neovascularization was examined with Doppler optical coherence tomography (OCT), and the three-dimensional architecture of the feeder vessels could be clearly visualized in the Doppler OCT angiography image, showing the site of growth of the feeder vessels passing through Bruch’s membrane. Together, the results demonstrated in this case report that Doppler OCT was useful for the noninvasive assessment of feeder vessels in exudative macular disease.

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    9. New Journal Article Highlights Mechanical Effects of Orbital Atherectomy and Rotational Atherectomy in Treating Heavily Calcified Coronary Lesions

      New Journal Article Highlights Mechanical Effects of Orbital Atherectomy and Rotational Atherectomy in Treating Heavily Calcified Coronary Lesions

      Cardiovascular Systems, Inc. (CSI) (NASDAQ: CSII) today announced that a new article e-published in May 2015 in The Journal of Catheterization and Cardiovascular Intervention highlights the mechanical effect of orbital atherectomy (OA) and rotational atherectomy (RA) in treating heavily calcified coronary lesions. ” The article, titled “Optical Coherence Tomography Assessment of the Mechanistic Effects of Rotational and Orbital Atherectomy in Severely Calcified Coronary Lesions,” details results from a study led by Dr. Annapoorna Kini, Professor of Cardiology at the Mount Sinai Hospital and Icahn School of Medicine, and Director of The Cardiac Catheterization Lab at Mount Sinai Hospital. Said study co-investigator ...

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    10. Optical coherence tomography after POEM

      Optical coherence tomography after POEM

      Amy Tyberg, MD, from Weill Cornell Medical College in New York, New York, USA presents this video case “Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy.” This case describes a 51-year-old woman with achalasia who underwent a per-oral endoscopic myotomy (POEM) with complete resolution of her symptoms post-procedure. A repeat endoscopy with optical coherence tomography (OCT) was performed post-procedure to confirm successful myotomy.  

      OCT is an exciting new technology that allows for two-dimensional, cross-sectional imaging of the esophageal wall in vivo. This technology has been well studied in Barrett’s esophagus  as ...

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    11. Manipulating the spatial coherence of a laser source

      Manipulating the spatial coherence of a laser source

      Abstract: An efficient method for controlling the spatial coherence has previously been demonstrated in a modified degenerate cavity laser. There, the degree of spatial coherence was controlled by changing the size of a circular aperture mask placed inside the cavity. In this paper, we extend the method and perform general manipulation of the spatial coherence properties of the laser, by resorting to more sophisticated intra-cavity masks. As predicted from the Van Cittert Zernike theorem, the spatial coherence is shown to depend on the geometry of the masks. This is demonstrated with different mask geometries: a variable slit which enables independent ...

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    12. Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging

      Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging

      Noninvasive label-free imaging of biological systems raises demand not only for high-speed three-dimensional prescreening of morphology over a wide-field of view but also it seeks to extract the microscopic functional and molecular details within. Capitalizing on the unique advantages brought out by different nonlinear optical effects, a multimodal nonlinear optical microscope can be a powerful tool for bioimaging. Bringing together the intensity-dependent contrast mechanisms via second harmonic generation, third harmonic generation and four-wave mixing for structural-sensitive imaging, and single-beam/single-pulse coherent anti-Stokes Raman scattering technique for chemical sensitive imaging in the finger-print region, we have developed a simple and nearly ...

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    13. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de novo coronary lesions (in different vessels), with lesion length of ≤18 mm. The primary OCT endpoint was the percentage of in-stent neointimal volume obstruction at three months. The secondary endpoints ...

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    14. En Face Imaging of Posterior Precortical Vitreous Pockets Using Swept-Source Optical Coherence Tomography

      En Face Imaging of Posterior Precortical Vitreous Pockets Using Swept-Source Optical Coherence Tomography

      PURPOSE. To obtain sequential flat (en face) images of posterior precortical vitreous pockets (PPVPs) using swept-source optical coherence tomography (SS-OCT). METHODS. We performed SS-OCT in the right eyes of 112 volunteers (mean age, 30.1 years; mean refraction, 2.5 diopters) while sitting using 12-mm horizontal, vertical scans of the 12- 3 9-mm plane 3 2.6-mm depth through the macula and optic disc. En face images of the posterior vitreous were obtained by En-View, a SS-OCT program. RESULTS. Swept-source OCT visualized the PPVPs and Cloquet’s canals in all subjects; the PPVPs appeared as boat-shaped lacunae in the horizontal ...

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      Mentions: Gunma University
    15. Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

      Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

      Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter changes might also occur in these patients. We assessed posterior changes through the use of optical coherence tomography and compared to a nonkeratoconus patient group. All subjects underwent clinical examination including macular thickness measurements. The generalized estimation equation model was used to estimate the means and compare the differences in various measurements between keratoconus and nonkeratoconus patients. A total of 129 keratoconus eyes of 67 cases and 174 nonkeratoconus eyes of 87 controls were analysed. Keratoconus individuals presented with a significantly ...

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    16. See all articles
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  6. Picture Gallery

    Avinger Announces 30-Day VISION Trial Results at EuroPCR 2015 Demonstration of tolerance to dispersion of master/slave interferometry Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle Noninvasive cross-sectional observation of three-dimensional cell sheet-tissue-fabrication by optical coherence tomography New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015 Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions "Eye on Vision" Radio Interview with Dr. David Huang Regarding  OCT Angiography Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos) Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue Tiny Camera Sees Inside Blood Vessels Optical Coherence Elastography
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    2. The ophthalmic optical coherence tomography (OCT) application was one of the key drivers.
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