1. Featured Articles

    1. Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal

      We opened a tender for selecting a Post-Doctoral Researcher with a contract for an open-ended period of time. We are looking for someone with a Doctoral degree in Biomedical Engineering, Physics Engineering, Physics, Electrotechnical Engineering or a closely related area, knowledge in optoelectronic instrumentation, photonics, optics and electronics and knowledge in programming. The position concerns the ElastoOCT project - Optical Coherence Elastography for imaging retina mechanical properties – and is available at the University of Coimbra, Portugal. The aim of the project is to develop and build an optical coherence elastography system for retinal imaging, with ultrasound excitation and measurement of induced ...

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      Mentions: University of Coimbra

    2. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      Explore Wiley Online Library Urology
      The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology ...

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      Mentions: Ton G. van Leeuwen Daniël M. de Bruin Theo M. de Reijke

    3. Expert consensus published on use of imaging to guide heart attack treatment

      Explore escardio.org Cardiology
      Expert consensus published on use of imaging to guide heart attack treatment

      Imaging provides a more precise diagnosis of a heart attack that can be used to individualise treatment. That’s the main message of an expert consensus paper published today 1 in European Heart Journal, a journal of the European Society of Cardiology (ESC), and presented at EuroPCR in Paris, France. 2 Heart attacks are diagnosed and treated using coronary angiography, an invasive procedure which provides an X-ray outline of the arteries supplying blood to the heart. Invasive imaging of the arteries gives more detail but there has been controversy over when to use it. This document seeks to resolve that ...

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      Mentions: European Society of Cardiology Giulio Guagliumi

    4. Research Scientist for Optical Diagnostic at Carestream Dental

      Explore Optical Coherence Tomography News Dentistry , Jobs & Studentships
      Research Scientist for Optical Diagnostic at Carestream Dental

      We are seeking a Research Scientist for Optical Diagnostics to be part of an innovative research team (based in Rochester, New York) that develops new optical devices for improving measurements and diagnoses in dentistry. Position Description: Research Scientist who will research and develop new optical technologies for dental measurements and diagnostics Conceptualize and demonstrate new applications of optics and photonics in solving problems in modern dentistry and advancing the field Design, implement, and develop experimental and prototype systems and perform clinical evaluation Collaborate with a multi-disciplinary team to translate technology solution into commercial product H-1B Candidates are welcome to apply ...

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      Mentions: Carestream Dental

    5. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      Explore Journals Cardiology
      Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular imaging can provide additional important diagnostic information when confronted with angiographically ambiguous lesions and allows assessment of plaque morphology enabling identification of vulnerability characteristics. This second document focuses on useful ...

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      Mentions: Imperial College London Cardiovascular Research Foundation Gary S. Mintz

    6. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Explore Wiley Online Library Neurology , Ophthalmology
      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected in a subset ...

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      Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer

    7. PhD Studentship Opening at The University of Liverpool

      Explore Optical Coherence Tomography News Jobs & Studentships
      PhD Studentship Opening at The University of Liverpool

      PhD studentship in the development of optical coherence tomography (OCT) and artificial intelligence (AI) for precisely and automatically measurement of the corneal power. Successful students will receive a studentship of tuition fees paid at the Home/EU rate for 3.5 years and a stipend of £15,009 per annum for 3.5 years. In addition, students will have access to a research support fund of £1,000 per annum for purchasing equipment, consumables and conference costs co-managed by the academic supervisor. The project is supported by the University of Liverpool Doctoral Network in Future Digital Health, which is directed ...

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    8. Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral positions immediately open at Boston University School of Medicine, Boston Medical Center. About the position : We are looking for highly motivated individuals to join the lab, to develop novel optical imaging techniques for ophthalmic and endoscopic applications. Candidates with experiences on ophthalmic imaging, endoscopy, optical coherence tomography, fiber sensing and imaging system will be highly competitive. The position will require PhD degree on scientific discipline, for example, electrical engineering, computer science, biomedical engineering etc. The position also requires good communication skill, willingness for collaboration, and is expected to independently publish scientific papers. Please contact the PI, Dr. Ji Yi ...

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      Mentions: National Institutes of Health Boston University Ji Yi

    9. Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Avinger, Inc. (AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of patients with Peripheral Artery Disease (PAD), today announced that physicians in 78 clinical sites have successfully treated more than 1,000 patients with the next-generation Pantheris image-guided atherectomy system. The next-generation Pantheris was launched on a limited basis in the U.S. following receipt of 510(k) clearance by the U.S. Food and Drug Administration (FDA) in late May 2018 and features a number of improvements intended to augment the performance and reliability of the product. Importantly ...

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      Mentions: FDA Avinger

    10. Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Ping An Insurance (Group) Company of China, Ltd. is pleased to announce that its technology arm, Ping An Technology, has completed a prospective multi-center clinical trial for the world's first intelligent optical coherence tomography (OCT) retinal disease screening system. The screening system is jointly developed by Ping An Technology and US-based Optovue, Inc. It is the first artificial intelligence (AI) imaging and screening system in the world that seamlessly integrates an OCT retinal imaging device and AI lesion detection software. The clinical trial was conducted at three well-known research institutions, the Eye and ENT Hospital of Fudan University in ...

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      Mentions: Optovue Shanghai Jiao Tong University

    11. In vivo volumetric imaging by crosstalk-free full-field OCT

      Explore OSA | OSA Publishing
      In vivo volumetric imaging by crosstalk-free full-field OCT

      Cellular resolution imaging of biological structures has always been a challenge due to strong scattering that limits the achievable transverse resolution or imaging penetration depth. Recently, a major advancement toward high-resolution and volumetric imaging was achieved by implementing a parallel detection (i.e., full field) into Fourier-domain optical coherence tomography. The drawback of using parallel detection is that scattered light can travel laterally and get mapped improperly at a camera creating optical crosstalk, which severely impairs the interpretation of subcellular images and limits its use in medical diagnostics. In this work, we demonstrate for what we believe is the first ...

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      Mentions: Maciej Wojtkowski Nicolaus Copernicus University

    12. EXALOS Introduces RGB Modules for Augmented Reality and Head-up Display Applications

      Explore Optical Coherence Tomography News Other Business News , Broadband Sources
      EXALOS Introduces RGB Modules for Augmented Reality and Head-up Display Applications

      Schlieren, Switzerland, May 6 th , 2019. EXALOS, the world’s leading developer of visible Superluminescent Light Emitting Diodes (SLEDs), has expanded its product porfolio with the introduction of a compact RGB SLED module that will enable the advancement of micro-display architectures for augmented reality (AR) and head-up displays (HUDs). The RGB module constitutes three SLED chips housed in a 14-pin butterfly package (20.8 mm x 1.7 mm) with a total output power of about 30 mW (~ 10 mW/color), which corresponds to a total luminous flux of 5 lm. The individual chips (635 nm (R), 510 nm (G ...

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      Mentions: Exalos Kevin Hsu

    13. NinePoint Medical Announces Publication of 1000 Patient Registry Study

      Explore Optical Coherence Tomography News Gastroenterology , Other Non-Medical , Clinical Trials
      NinePoint Medical Announces Publication of 1000 Patient Registry Study

      NinePoint Medical, Inc, a transformative medical device company pioneering the use of Optical Coherence Tomography (OCT) for gastrointestinal applications, today announced the publication of their 1000 patient Volumetric Laser Endomicroscopy (VLE) Registry study focused on Barrett’s Esophagus. The 18 site study, published in Diseases of the Esophagus , enrolled 1000 patients between 2014 and 2016 for imaging using the NvisionVLE® Imaging System. The study was designed to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics, with this publication focused on Barrett’s Esophagus. All enrolled patients were examined with standard upper endoscopy ...

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      Mentions: FDA NinePoint Medical Eman Namati

    14. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Explore SPIE Digital Library Dermatology
      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ratio and contain imaging artifacts. Previous work on automatic vessel segmentation in OCTA mostly focuses on retinal and cerebral vasculature. Its applicability to skin and, furthermore, its robustness against imaging ...

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      Mentions: Massachusetts General Hospital Harvard University Gereon Hüttmann

    15. High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

      Explore jnis.bmj.com Cardiology , Neurology
      High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

      Background High frequency optical coherence tomography (HF-OCT) is a novel intravascular imaging technology developed for use in the cerebral vasculature. We hypothesize that HF-OCT characterization of intrasaccular device neck coverage can prognosticate exclusion of the aneurysm from the circulation. Methods Bifurcation and sidewall aneurysms were made in six dogs. Seven aneurysms were treated with next generation intrasaccular devices (NGID) and four with traditional platinum coils. HF-OCT was performed to interrogate gaps in the neck coverage, coil herniation, or acute thrombus formation. Animals were re-imaged at 7, 30, 90, and 180  days following aneurysm embolization. An automated image processing method segmented ...

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      Mentions: Giovanni J. Ughi Gentuity

    16. Permanent Professor Position available at University of Lubeck

      Explore Optical Coherence Tomography News Jobs & Studentships
      Permanent Professor Position available at University of Lubeck

      The Institute of Biomedical Optics at the Department of Computer Science/Engineering and Department of Natural Sciences (STEM) at the Universität zu Lübeck invites applications for a permanent University Professorship (W2) in Biomedical Optics and Photonics commencing as soon as possible. Conditions of the appointment are in accordance with the Higher Education Act (Hochschulgesetz) of Schleswig Holstein. Details will be explained on request. The successful candidate will represent the respective field in research and teaching. The overall focus of the professorship lies on novel physics approaches in optics and their development to the point of application in the ...

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      Mentions: Thorlabs Heidelberg Engineering University of Lübeck

    17. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

      Explore Journals Gastroenterology
      Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

      Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE ...

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      Mentions: Hiroshi Mashimo NinePoint Medical Michael B. Wallace

    18. Ultralow-voltage electrothermal MEMS based fiber-optic scanning probe for forward-viewing endoscopic OCT

      Explore OSA | OSA Publishing Probes
      Ultralow-voltage electrothermal MEMS based fiber-optic scanning probe for forward-viewing endoscopic OCT

      We report an ultralow-voltage, electrothermal (ET) micro-electro-mechanical system (MEMS) based probe for forward-viewing endoscopic optical coherence tomography (OCT) imaging. The fully assembled probe has a diameter of 5.5 mm and a length of 55 mm, including the imaging optics and a 40 mm long fiber-optic cantilever attached on a micro-platform of the bimorph ET MEMS actuator. The ET MEMS actuator provides a sufficient mechanical actuation force as well as a large vertical displacement, achieving up to a 3 mm optical scanning range with only a 3

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      Mentions: Johns Hopkins University University of Florida Huikai K. Xie

    19. PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      Explore Optical Coherence Tomography News Otolaryngology , Clinical Trials , Other Business News
      PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc., a medical device company headquartered in Champaign, Illinois, announces successful initiation of a multi-site registered clinical study to evaluate the imaging capabilities and image analysis performance of the PhotoniCare TOMi Scope. Children’s National Health System (Washington, D.C.) is the first initiated of two clinical sites involved in this registered multi-site clinical study, along with Carle Foundation Hospital (Urbana, Illinois). The study is led by Dr. Diego Preciado, Children’s National, and Dr. Ryan Porter, Carle Hospital, along with a team of recognized otitis media experts at both clinical sites. This multi-center study plans to enroll a ...

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      Mentions: National Institutes of Health University of Illinois at Urbana-Champaign PhotoniCare

    20. Light-scattering methods for tissue diagnosis

      Explore OSA | OSA Publishing
      Light-scattering methods for tissue diagnosis

      Light scattering has become a common biomedical research tool, enabling diagnostic sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are particularly attractive for diagnostics due to the variety of contrast mechanisms that can be used, including spectral, angle-resolved, and Fourier-domain detection. Photonic diagnostic tools offer further benefits in that they are non-ionizing, non-invasive, and give real-time feedback. In this review, we summarize recent innovations in light-scattering technologies, with a focus on clinical achievements over the previous ten years.

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      Mentions: Duke University Adam Wax
    21. See all articles

  2. Recent Articles From Around The Web

    1. Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

      Explore IOVS Journal Ophthalmology
      Impact of Posterior Sclera on Glaucoma Progression in Treated Myopic Normal-Tension Glaucoma Using Reconstructed Optical Coherence Tomographic Images

      Purpose : To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods : Fifty-six myopic patients on ocular hypotensive therapy with the diagnose NTG had five or more VF tests during a period of 72.63 ± 20.46 months in clinical follow-up. Glaucomatous VF progression was decided by the standards of Early Manifest Glaucoma Trial criteria. Coronally reconstructed OCT images were used to obtain the position of the deepest point of the eye (DPE), and parameterized the distance (Disc-DPE distance), depth (Disc–DPE ...

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    2. Intravascular Ultrasound and Optical Coherence Tomography in the Procedural Planning and Execution of Left Main Coronary Artery Percutaneous Coronary Intervention

      Explore Home - Springer Cardiology
      Intravascular Ultrasound and Optical Coherence Tomography in the Procedural Planning and Execution of Left Main Coronary Artery Percutaneous Coronary Intervention

      Purpose of Review Left main coronary artery disease (LMCAD) is a frequently encountered, high-risk presentation of atherosclerosis, traditionally managed with surgical bypass grafting. Percutaneous coronary intervention (PCI) for LMCAD is an increasingly attractive option for patients with low to intermediate complexity disease or patients at extremely high or prohibitive surgical risk. The goal of this review is to outline the current indications and guideline recommendations regarding PCI for LMCAD and the role of intracoronary imaging in optimizing these cases. Recent Findings Several recent randomized controlled trials have demonstrated the non-inferiority of PCI in LMCAD compared with CABG. Further, the use ...

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      Mentions: University of Washington Peking University

    3. Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography

      Explore Hindawi Publishing Corporation Ophthalmology
      Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography

      Purpose . To evaluate the changes in retinal vessel density and thickness after small incision lenticule extraction (SMILE) with optical coherence tomography angiography (OCTA) in myopic patients. Methods . In this prospective study, SMILE surgeries were done in 46 eyes of 24 patients with spherical equivalent (SE) more than −6.0 diopters ( D ). Retinal vessel density and thickness at the macula and optic nerve were recorded with OCTA before and 1 day, 2 weeks, and 1 month after surgery. Intraocular pressure (IOP), uncorrected distance visual acuity (UDVA), and refraction were taken at the same time. Results . The superficial retinal vessel density and ...

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      Mentions: Fudan University Chinese Academy of Sciences

    4. Mapping diurnal variations in choroidal sublayer perfusion in patients with idiopathic epiretinal membrane: an optical coherence tomography angiography study

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Mapping diurnal variations in choroidal sublayer perfusion in patients with idiopathic epiretinal membrane: an optical coherence tomography angiography study

      Background Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the choroidal vasculature and perfusion state. In this index study, OCTA was used to investigate diurnal changes in choroidal sublayer perfusion in eyes with idiopathic epiretinal membrane (ERM) and to identify impacting factors. Methods A prospective study was conducted on volunteers with symptomatic ERM, each of whom underwent repeated measurements of subfoveal choroidal thickness (SFCT) using enhanced-depth imaging optical coherence tomography and perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 p.m., and 8 p.m. Possible interactions between ...

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    5. Automatic detection of retinal regions using fully convolutional networks for diagnosis of abnormal maculae in optical coherence tomography images

      Explore SPIE Digital Library Ophthalmology
      Automatic detection of retinal regions using fully convolutional networks for diagnosis of abnormal maculae in optical coherence tomography images

      In conventional retinal region detection methods for optical coherence tomography (OCT) images, many parameters need to be set manually, which is often detrimental to their generalizability. We present a scheme to detect retinal regions based on fully convolutional networks (FCN) for automatic diagnosis of abnormal maculae in OCT images. The FCN model is trained on 900 labeled age-related macular degeneration (AMD), diabetic macular edema (DME) and normal (NOR) OCT images. Its segmentation accuracy is validated and its effectiveness in recognizing abnormal maculae in OCT images is tested and compared with traditional methods, by using the spatial pyramid matching based on ...

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      Mentions: Sun Yat-Sen University Tsinghua University

    6. Ocular albinism with mutation in GPR143: Findings in wide-field autofluorescence and optical coherence tomography

      Explore ScienceDirect Ophthalmology
      Ocular albinism with mutation in GPR143: Findings in wide-field autofluorescence and optical coherence tomography

      A 12 year-old boy who consulted due to nystagmus and low vision from birth. His mother also consulted for low vision of the right eye since she was a child, which worsened recently. The physical examination revealed no alterations in skin and hair pigmentation. In the examination of the anterior segment of the child, areas of slight circumferential hypopigmentation were observed in the iris in both eyes. The fundus examination revealed a choroidal fundus due to the absence of melanin in the retinal pigment epithelium. In the autofluorescence, an absence of physiological macular hypo-autofluorescence was observed and, in optical coherence ...

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    7. Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography

      Explore ScienceDirect Ophthalmology
      Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography

      Purpose Only an endophytic growth pattern in juxtapapillary retinal hemangioblastoma (JRH) is an indication for surgical treatment, but classification of growth types is difficult using conventional imaging techniques. This case report describes the use of optical coherence tomography angiography (OCT-A) features for classification and treatment follow-up in a case with JRH. Observations The JRH of this patient was easily detected with two different OCT-A methods in both en-face and cross-sectional B-scan images, and was classified as a sessile growth type. This growth type excluded the treatment option of vitreoretinal surgery with excision of the lesion or ligation of the feeder ...

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      Mentions: Johannes F. de Boer VU University Amsterdam Koen A. Vermeer

    8. Optical coherence tomography imaging of cardiac substrates

      Explore Home Cardiology
      Optical coherence tomography imaging of cardiac substrates

      Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Knowledge of a patient’s heart structure will help to plan procedures, potentially identifying arrhythmia substrates, critical structures to avoid, detect transplant rejection, and reduce ambiguity when interpreting electrograms and functional measurements. Similarly, basic research of numerous cardiac diseases would greatly benefit from structural imaging at cellular scale. For both applications imaging on the scale of a myocyte is needed, which is approximately 100 µm × 10 µm. The use of optical coherence tomography (OCT) as a tool for characterizing cardiac tissue structure and function has been ...

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      Mentions: Columbia University Christine P. Hendon

    9. Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

      Explore Home - ClinicalTrials.gov Neurology , Ophthalmology , Clinical Trials
      Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

      The visual prognosis of optic neuritis not related to multiple sclerosis is unknown, both in terms of functional recovery and evolution. This prospective cohort study aim to assess the ophthalmological evolution of patients presenting an episode of optic neuritis (NO) not related to a multiple sclerosis or to a clinically isolated syndrome.

      Read Full Article

    10. Macular Microvascular Networks In Healthy Pediatric Subjects

      Explore LWW Online Ophthalmology
      Macular Microvascular Networks In Healthy Pediatric Subjects

      Purpose: To report optical coherence tomography angiography ( OCTA ) values in healthy pediatric eyes and to identify factors that may modify these values. Methods: In this prospective observational cross-sectional study, macular OCTA images were acquired from healthy pediatric patients. Main outcome measures were 1) foveal avascular zone (FAZ) area at the level of the superficial retinal capillary plexus (SCP); 2) SCP and deep retinal capillary plexus (DCP) perfusion density (based on the area of vessels); 3) SCP and DCP vessel density (based on a map with vessels of 1-pixel width); and 4) CC perfusion density. Multiple regression analysis was performed to ...

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      Mentions: Srinivas R. Sadda UCLA

    11. Vascular Alterations Revealed With Optical Coherence Tomography Angiography In Patients With Choroideremia

      Explore LWW Online Ophthalmology
      Vascular Alterations Revealed With Optical Coherence Tomography Angiography In Patients With Choroideremia

      Purpose: Choroideremia is a rare degenerative retinal disease that causes incurable blindness. It occurs as a result of the deficiency of the X-linked CHM gene, which encodes the Rab escort protein 1 (REP1). Gene therapy has been developed to treat CHM using adeno-associated viral vectors and is currently undergoing clinical trials. Expression of the CHM gene is ubiquitous throughout the retina, and it is therefore important to identify which retinal layers are affected in the disease process. The purpose of this study was to assess in particular the choriocapillaris using optical coherence tomography angiography because this layer is difficult to ...

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      Mentions: Oxford University Università Vita-Salute San Raffaele

    13. Chalcogenide-glass polarization-maintaining photonic crystal fiber for mid-infrared supercontinuum generation

      Explore arxiv.org Broadband Sources
      Chalcogenide-glass polarization-maintaining photonic crystal fiber for mid-infrared supercontinuum generation

      In this paper, we report the design and fabrication of a highly birefringent polarization-maintaining photonic crystal fiber (PM-PCF) made from chalcogenide glass, and its application to linearly-polarized supercontinuum (SC) generation in the mid-infrared region. The fiber was drawn using the casting method from As38Se62 glass which features a transmission window from 2 to 10 µm and a high nonlinear index of 1.13×10-17 m2 /W. It has a zero-dispersion wavelength around 4.5 µm and, at this wavelength, a large birefringence of 6×10-4 and consequently strong polarization maintaining properties are expected. Using this fiber, we experimentally demonstrate supercontinuum ...

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      Mentions: Technical University of Denmark (DTU)

    14. Supervised machine learning based multi-task artificial intelligence classification of retinopathies

      Explore arxiv.org Ophthalmology
      Supervised machine learning based multi-task artificial intelligence classification of retinopathies

      Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to ...

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      Mentions: Xincheng Yao

    15. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      Explore ScienceDirect Ophthalmology
      OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural ...

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      Mentions: Johns Hopkins University Mount Sinai School of Medicine University of Alabama
      16. See all articles
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    Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study Expert consensus published on use of imaging to guide heart attack treatment Research Scientist for Optical Diagnostic at Carestream Dental Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study PhD Studentship Opening at The University of Liverpool Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system In vivo volumetric imaging by crosstalk-free full-field OCT EXALOS Introduces RGB Modules for Augmented Reality and Head-up Display Applications

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    1. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    2. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
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    3. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    4. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    5. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    6. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden
    7. We are very excited and honored to partner with the team at Adachi. Adachi’s strong market presence in Otolaryngology, as well as their expertise in navigating Japanese regulatory and reimbursement pathways, will ensure a powerful launch of the TOMi Scope in the Japanese marketplace. We see this partnership as further validation of our technology and its potential to impact healthcare in a meaningful way. We look forward to a long and fruitful relationship with Adachi.
      By Ryan L. Shelton
    8. You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube...Many lesions in the mouth have been re-mineralized and...no longer need inter­vention,” said Fried. “Dentists have trouble telling the difference between active and arrested lesions; this new technology has the potential of differentiating them.
      By Daniel S. Fried
    9. OCT [already] has changed the practice of ophthalmol­ogy...It’s been very successful for retinal imaging...and it’s also very promising for dentistry...If the dentist doesn’t know if [a lesion] is active or arrested,” said Fried, “with OCT, you can actually see the lesion struc­ture, how deep it is and if it has a definitive surface zone suggesting that remineralization has occurred.
      By Daniel S. Fried
    10. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson