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  3. Organizations in the News

    (4 articles) University of Miami

    (2 articles) University of Wisconsin

    (1 articles) University of Otago

    (1 articles) Prince of Songkla University

    (1 articles) Ludwig Maximilians Universität München

    (1 articles) Massachusetts Eye and Ear Infirmary

    (1 articles) Yonsei University

    (1 articles) University of Central Florida

    (1 articles) UCSD

    (1 articles) University of Melbourne

  4. People in the News

    (2 articles) Marco B. Ruggeri

    (1 articles) Dirk-Uwe G. Bartsch

    (1 articles) Chittanon Buranachai

    (1 articles) Emily J. McDowell

    (1 articles) Jian Ren

    (1 articles) William R. Freeman

    (1 articles) Igor Kozak

    (1 articles) Piotr Targowski

    (1 articles) Francesca Mojana

    (1 articles) Teresa C. Chen

  5. OCT Companies in the News

    (5 articles) Carl Zeiss Meditec

    (3 articles) Volcano

    (3 articles) Bioptigen

    (3 articles) Axsun Technologies

    (3 articles) LightLab Imaging

    (1 articles) Siemens

    (1 articles) Heidelberg Engineering

    (1 articles) Optovue

    (1 articles) Imalux

    (1 articles) Heliotis AG

  6. OCT Products in the News

    (3 articles) Zeiss Stratus OCT

    (1 articles) Heidelberg Spectralis

    (1 articles) Zeiss Cirrus HD-OCT

  7. Picture Gallery

  8. Popular Articles

  9. Recent Quotes

    1. “ There is only one other imaging instrument on the market dedicated to pediatric eye care, and no other OCT system. ”
      By Eric L. Buckland
    2. “ What the SBIR grants allow us to do is address some of the underserved areas of ophthalmology, such as pediatrics...Knowing that our system can play a role in saving the eyesight of young children is very satisfying. ”
      By Eric L. Buckland
    3. “ The fundamental difficulty is that angiography is a bad way to look at thrombus...In the absence of a total occlusion, where you can’t estimate thrombus, the only technique that might have a chance to provide a good estimate is optical coherence tomography (OCT), because OCT can distinguish between plaque and thrombus while IVUS cannot. ”
      By David P. Faxon
    4. “ It is an honor to be recognized by SPIE with this Prism Award. This shows how the many years of hard work put in by the people here at LightLab in developing the C7 XR™ system is being recognized by their peers. ”
      By Joseph M. Schmitt
    5. “ We are pleased and honored to receive the Prism Award for our C7 XR Imaging System, as this represents an important recognition of this product from a Society representing the top innovators in optics and photonics. ”
      By David W. Kolstad
    6. “ NPL's phantoms and analysis have enabled us to validate our performance claims beyond doubt. We expect this validation to give OCT technology the backing it needs to become standard in hospitals around the world and thereby make an important leap in the battle against cancer. ”
      By Jon Holmes
    7. “ We anticipate that eventually such phantoms will be shipped with OCT systems when they are used clinically, together with a set of guidelines highlighting how they are to be used. ”
      By Pete H. Tomlins
    8. “ By removing the point-spread function from the data, we have actually seen an improvement of several microns in resolution of an OCT instrument, which is very exciting. We have demonstrated that you can now resolve two points that previously couldn't be resolved. ”
      By Pete H. Tomlins
    9. “ We developed breakthrough technology for imaging living tissue and for detecting diseases, but we needed to validate our performance claims, to provide customers with greater confidence in them. NPL's phantoms and analysis have enabled us to validate our claims beyond doubt, thereby demonstrating the superiority of our scanners and giving us the edge over our competitors. We expect that this validation will give OCT technology the backing it needs to become standard in hospitals around the world, and thereby make an important progression in the battle against cancer. ”
      By Jon Holmes
    10. “ Maybe in a couple of years we will be able to take images in the gastrointestinal suite and tell the patient right away whether they have a disease or cancer, and if they do, what grade it is. This way the patient can receive appropriate treatment in a timely manner. ”
      By Beau A. Standish

  1. Feature Of The Week

    Optical Coherence Tomography (OCT) is now an important modality in the field of biomedical imaging for its high resolution and non-invasive nature. People have been developing OCT endoscopes to penetrate into deep biological tissues and extend the limited light penetration depth in near infrared wavelength region. Different ways of steering the probing beam have been developed over the years. As most of them need some form of mechanical actuation, they usually come with the associated cost of additional hardware that must be integrated onto the probes. An OCT probe that can be manually swept over the region of interest by the user and provide a scan of the biological structure along its path, could simplify the imaging procedure. Recently researchers from the California Institute of Technology demonstrated some very interesting work on such an OCT probe. Below is a description provided courtesy of Jian Ren a graduate student in electrical engineering at Caltech.

    To achieve the above manual-scanning capability, we designed a new OCT probe based on position tracking. An optical monitoring system was first constructed, where the pose of a simple OCT probe can be continuously tracked while the user sweeps the probe over the region of interest manually. We can reconstruct either planar 2D images or volumetric 3D images, depending on user’s scan pattern, by orienting each OCT depth scan to their individual pose estimated by the system. This method can objectively track and record the actual scan pattern regardless of the scanning mechanism, while other mechanically-actuated OCT probes reconstruct images based on pre-determined scan patterns.

    In the tracking system, we employed four infrared LEDs as the feature points. A CMOS camera was used to take their images. We deployed a pair of object detection and tracking algorithms to search the location of the feature points in each frame and find their correspondence among a sequence of frames. A centroid estimator further improved this position estimation accuracy to sub-pixel level. By knowing the accurate distribution of the feature points, we applied a pose estimation algorithm known as Pose from Orthography and Scaling with ITerations (POSIT) to compute the pose. The poses were recorded and related to the concurrent OCT depth scans.

    We examined the tracking accuracy of our system by translating the probe in a controlled manner so that we can compare the position estimation with the actual. The results show the system has an accuracy of about 6 microns along two axes and 19 microns along the third. This matches well with the associated imaging resolution of the OCT system.

    A phantom sample with carved surface was used to validate this method. First, the probe sitting on a motorized stage scanned the sample’s surface, generating a control image. We then manually scanned the surface with free hands. The images reconstructed by the resolved poses conform much better to the control image than the images reconstructed solely based on their time order. We next imaged a 54-stage Xenopus laevis tadpole using this system. The resulting images exhibit the correction effects of this method and demonstrate its imaging capability.

    This new method comes with three major advantages. First, the manufacture of such an OCT imaging probe can be rather easy, as there is no actuation system; the low associated cost makes disposable probes possible. Second, the lightweight design provides the users greater control finesse. Third, it has significant flexibility as it allows the users to manually sweep the region of their interest along any arbitrary path, as long as the trajectory of the device is within the scope of the monitoring system.

    For more information see recent Article. Click "Full Screen" for better viewing. To share, bookmark, or forward this article click Here.

  2. Featured Articles

    1. Miniature actuator mechanism for intravascular imaging

      Explore Article PatFT » Page 1 of 1 (7 hours, 3 min ago) Patents , Probes

      Miniature actuator mechanism for intravascular imaging The present invention relates to a new intravascular imaging device based on a Shape Memory Alloy (SMA) actuator mechanism embedded inside an elongate member such as a guide wire or catheter. The present invention utilizes a novel SMA mechanism to provide side-looking imaging by providing movement for an ultrasound transducer element. This novel SMA actuator mechanism can be easily fabricated in micro-scale, providing an advantage over existing imaging devices because it offers the ability to miniaturize the overall size of the device, while the use of multiple transducer crystals maximizes field of view. Also disclosed are methods of using the ... (Read Full Article)

      Comment on Article

    2. OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      Explore Article imaging.onlinejacc.org (14 hours, 2 min ago) Cardiology

      OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries Objectives We evaluated the geographic distribution of thin-cap fibroatheromas (TCFAs) in the coronary arteries using optical coherence tomography (OCT), a high-resolution imaging modality. Background Plaque rupture is the most frequent cause of acute myocardial infarction (AMI). It has been recognized that TCFA is the primary plaque type at the site of plaque rupture. Methods We performed 3-vessel OCT examinations in 55 patients: 35 AMI and 20 stable angina pectoris patients. The criteria for TCFA in an OCT image was a lipid-rich plaque with fibrotic cap thickness <65 µm. The distance between each TCFA location and the respective coronary artery ostium ... (Read Full Article)

      Comment on Article Mentions:   Kenichi Fujii   Motomaru Masutani

    3. Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography

      Explore Article www3.interscience.wiley.com (Feb 8 2010) Oncology , Probes

      Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography Optical coherence tomography (OCT) holds great promise as a routine research tool for analysis of identifying the boundaries between normal and diseased breast tissue in vitro and in vivo. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of glycerol in human cancer and normal breast tissues with OCT for functional imaging to monitor. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that the OCT imaging depth and imaging contrast of breast tissues have been improved after application of 60% glycerol ... (Read Full Article)

      Comment on Article

    4. Plant photonics: application of optical coherence tomography to monitor defects and rots in onion

      Explore Article www3.interscience.wiley.com (Feb 8 2010) Other Non-Medical

      Plant photonics: application of optical coherence tomography to monitor defects and rots in onion The incidence of physiological and/or pathological defects in many fresh produce types is still unacceptably high and accounts for a large proportion of waste. With increasing interest in food security their remains strong demand in developing reliable and cost effective technologies for non-destructive screening of internal defects and rots, these being deemed unacceptable by consumers. It is well recognized that the internal defects and structure of turbid scattering media can be effectively visualized by using optical coherence tomography (OCT). In the present study, the high spatial resolution and advantages of OCT have been demonstrated for imaging the skins and outer ... (Read Full Article)

      Comment on Article Mentions:   Igor V. Meglinski   Chittanon Buranachai   Prince of Songkla University

    5. Diagnostic Efficacy of Real-Time Optical Coherence Tomography in the Management of Preinvasive and Invasive Neoplasia of the Uterine Cervix

      Explore Article LWW Online (Feb 6 2010) Gynecology , Oncology

      Diagnostic Efficacy of Real-Time Optical Coherence Tomography in the Management of Preinvasive and Invasive Neoplasia of the Uterine Cervix Objective: Determine the sensitivity and specificity of optical coherence tomography (OCT) as an adjunct to colposcopy in the detection of cervical intraepithelial neoplasia (CIN) grade 2 or higher in a real-time clinical evaluation. Background: Optical coherence tomography (OCT) uses infrared light similar to ultrasound pulse-echo imaging. Image resolution is optimal in the 1-to-3-mm range. This study is the third in our series of OCT investigations and our first real-time clinical trial. The study was conducted at the Peking University Shenzhen Hospital, Shenzhen, China. Methods: Nonpregnant women 18 years or older with abnormal cervical cytologic findings or a positive high-risk human ... (Read Full Article)

      Comment on Article Mentions:   Imalux   Nancy J. Tresser

    6. Lightlab Imaging, Axsun Technologies, and Volcano Corporation in Legal Dispute – Part II

      Explore Article Optical Coherence Tomography News (Feb 5 2010) Cardiology , Other Business News

      Lightlab Imaging, Axsun Technologies, and Volcano Corporation in Legal Dispute – Part II It has been over one year since a lawsuit was filed by Lightlab Imaging against Axsun Technologies and Volcano Corporation (see previous Article). During 2009 lots of complex motions were filed and depositions were taken from various witnesses. The court proceedings before a jury began January 4th, 2010 and ran for nearly a month at the Superior Court in Boston. On Monday February 1st, 2010 the final closing arguments were given by the three parties and the judge charged the jury to consider the fourteen charged complaints against Axsun and Volcano. On Thursday, after four days of deliberating, the jury ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   Axsun Technologies   Volcano

    7. Coupled cavity InGaAsP/InP laser for synthetic optical coherence tomography and other applications

      Explore Article IEEE Xplore (Feb 4 2010) Tunable Sources

      Coupled cavity InGaAsP/InP laser for synthetic optical coherence tomography and other applications The authors describe widely tunable coupled cavity semiconductor lasers with sub-microsecond switching times between modes over the operating range of &#x002DC;100 nm. With appropriate modulation of injection currents and time averaging of the output, these devices provide short coherence lengths and can be an excellent source for synthesised optical coherence tomography (OCT). The depth resolution was found to be &#x002DC;15 mm for a 100 nm wavelength tuning range centred at 1580 nm. High-output power and brightness together with a short coherence length confers on these asymmetric multiple quantum well (AMQW) C3 laser some advantages over conventional sources for OCT. Also, ... (Read Full Article)

      Comment on Article

    8. Carl Zeiss Meditec and University of Miami sued Optovue over Patent Infringement

      Explore Article Bloomberg.com (Feb 4 2010) Ophthalmology , Other Business News , Patents

      Carl Zeiss Meditec and University of Miami sued Optovue over Patent Infringement Carl Zeiss Meditec AG (AFX GY): A unit of the maker of medical lasers to correct vision defects and the University of Miami sued California-based Optovue Inc. in federal court in Delaware over claims it infringed two patents for technology to map the eye. (Read Full Article)

      Comment on Article Mentions:   Optovue   Carl Zeiss Meditec   University of Miami

    9. Gabor-based fusion technique for Optical Coherence Microscopy

      Explore Article opticsinfobase.org (Feb 4 2010) Dermatology , Developmental Biology , Microscopy

      Gabor-based fusion technique for Optical Coherence Microscopy We recently reported on an Optical Coherence Microscopy technique, whose innovation intrinsically builds on a recently reported - 2 μm invariant lateral resolution by design throughout a 2 mm cubic full-field of view - liquid-lens-based dynamic focusing optical probe [Murali et al.,Optics Letters 34, 145-147, 2009]. We shall report in this paper on the image acquisition enabled by this optical probe when combined with an automatic data fusion method developed and described here to produce an in-focus high resolution image throughout the imaging depth of the sample. An African frog tadpole (Xenopus laevis) was imaged with the novel probe and ... (Read Full Article)

      Comment on Article Mentions:   University of Rochester   University of Central Florida

    10. Imaging method for eye disease used to eye art forgeries

      Explore Article PhysOrg.com (Feb 3 2010) Art

      Imaging method for eye disease used to eye art forgeries Scientists in Poland are describing how a medical imaging technique has taken on a second life in revealing forgery of an artist's signature and changes in inscriptions on paintings that are hundreds of years old. A report on the technique, called optical coherence tomography (OCT), is in ACS' Accounts of Chemical Research. Piotr Targowski notes that easel paintings prepared according to traditional techniques consist of multiple layers. The artist, for instance, first applies a glue sizing over the canvas to ensure proper adhesion of later layers. Those layers may include an outline of the painting, the painting itself, layers of ... (Read Full Article)

      Comment on Article Mentions:   Nicolaus Copernicus University   Piotr Targowski

    11. Optical coherence tomography of the upper urinary tract: Review of initial experience ex vivo and in vivo

      Explore Article ScienceDirect (Feb 3 2010) Urology

      Optical coherence tomography of the upper urinary tract: Review of initial experience ex vivo and in vivo Diagnostic imaging of the upper urinary tract is a cumbersome process that involves a multitude of different imaging modalities, including ultrasonography, conventional radiography, X-ray fluoroscopy (retrograde and antegrade ureteropyelography), endoscopy (cystoscopy and ureterorenoscopy) without or with biopsy, multi-detector-row computed tomography (MDCT), and magnetic resonance imaging (MRI). However, these modalities leave a diagnostic gap because they cannot demonstrate different layers of the wall of the upper urinary tract. Recent research shows that catheter-based, intraluminal probes for optical coherence tomography (OCT) with near-infrared light provide cross-sectional images from within the lumen of the upper urinary tract that distinguish between the urothelium, lamina ... (Read Full Article)

      Comment on Article Mentions:   Siemens   Ludwig Maximilians Universität München

    12. Depth-resolved wavefront aberrations using a coherence-gated Shack-Hartmann wavefront sensor

      Explore Article opticsinfobase.org (Feb 3 2010)

      Depth-resolved wavefront aberrations using a coherence-gated Shack-Hartmann wavefront sensor In the present paper we investigate the possibility of narrowing the depth range of a physical Shack – Hartmann (SH) wavefront sensor (WFS) by using coherence gating. For the coherence gating, two low coherence interferometry (LCI) methods are evaluated and proof of principle configurations demonstrated: (i) a time domain LCI method based on phase shifting interferometry and (ii) a spectral domain LCI method, based on tuning a narrow band optical source. The two configurations are used to demonstrate each, the possibility of constructing a coherence gated (CG) SH/WFS. It is shown that these configurations produce spot patterns similar to those ... (Read Full Article)

      Comment on Article Mentions:   Adrian G. Podoleanu   University of Kent

    13. Big Ideas from Small Businesses: Vision-related research by innovative thinkers - Imaging the eyes of infants

      Explore Article nei.nih.gov (Feb 2 2010) Ophthalmology , Other Business News

      Big Ideas from Small Businesses: Vision-related research by innovative thinkers - Imaging the eyes of infants In the early 2000s, Eric Buckland quit his job in the telecommunications industry to apply his Ph.D. in optics to life sciences. "In the community of physicians, researchers, and patients, there's a degree of passion that I hadn't seen in the telecommunications space," Buckland explains. He connected with Joseph Izatt, Ph.D., who was working at Duke University on optical coherence tomography (OCT). Similar to the way that ultrasound uses sound waves to generate images of body organs, OCT uses light waves to capture high-resolution images of living tissues. An OCT system for the eyes requires people to place their head ... (Read Full Article)

      Comment on Article Mentions:   Eric L. Buckland   Bioptigen   Joseph A. Izatt

    14. Interventional Cardiology: Principles and Practice (Book)

      Explore Article Wiley::Home (Feb 2 2010) Cardiology , Textbooks

      Interventional Cardiology: Principles and Practice (Book) This new volume offers a balanced and current presentation of the key topics that form the cornerstone of an Interventional Cardiology training program including sections on Optical Coherence Tomography. Globally recognized editors and contributors draw on their years of experience to provide practical information emphasizing the basics of material selection and optimal angiographic setup for purposes of the interventional procedure. Comprehensive chapters address the different techniques of approaching complex coronary lesions such as chronic occlusions, bifurcations, and unprotected left main lesions. (Read Full Article)

      Comment on Article Mentions:   Columbia University   Carlo Di Mario   Peter Barlis

    15. Swept-source polarization-sensitive
optical coherence tomography based on
polarization-maintaining fiber

      Explore Article opticsinfobase.org (Feb 2 2010)

      Swept-source polarization-sensitive
optical coherence tomography based on
polarization-maintaining fiber We present a swept-source polarization-sensitive optical coherence tomography system based on a polarization-maintaining fiber interferometer. The system produces reflectivity and birefringence information along a depth profile with a single sweep of the optical spectrum. Unlike single-mode fiber systems, retardance and relative optical axis orientation images are calculated without compensation. The source is a 45 mW polygon-based swept-source centered at 1290 nm and tuned at a rate of 28 kHz. The interferometer consists of a single polarization-maintaining coupler that utilizes balanced detection for improved performance. Characterization data shows that this system yields accurate measurements with high sensitivity (106.2 dB) comparable to ... (Read Full Article)

      Comment on Article Mentions:   Taner Akkin   University of Minnesota

    16. Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography

      Explore Article Institute of Physics (Feb 1 2010)

      Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography We present a new method for performing dynamic elastography of soft tissue samples. By sensing nanoscale displacements with optical coherence tomography, a chirped, modulated force is applied to acquire the mechanical spectrum of a tissue sample within a few seconds. This modulated force is applied via magnetic nanoparticles, named 'nanotransducers', which are diffused into the tissue, and which contribute negligible inertia to the soft tissue mechanical system. Using this novel system, we observed that excised tissues exhibit mechanical resonance modes which are well described by a linear damped harmonic oscillator. Results are validated by using cylindrical tissue phantoms of agarose ... (Read Full Article)

      Comment on Article Mentions:   University of Illinois at Urbana-Champaign   Stephen A. Boppart   Amy L. Oldenburg

    17. Intracoronary thrombus formation after drug-eluting stents implantation: Optical coherence tomographic study

      Explore Article American Heart Journal (Jan 31 2010) Cardiology

      Intracoronary thrombus formation after drug-eluting stents implantation: Optical coherence tomographic study Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated.Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus.Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P (Read Full Article)

      Comment on Article Mentions:   Yonsei University   LightLab Imaging

    18. Optical coherence tomography in Barrett's esophagus: the road to clinical utility

      Explore Article Gastrointestinal Endoscopy (Jan 31 2010) Endoscopy

      Optical coherence tomography in Barrett's esophagus: the road to clinical utility Will gastroenterologists ever push the “OCT button” on their endoscopes to obtain clinically actionable images? Nine years ago in this journal, optical coherence tomography (OCT) was described as ‘‘the most noteworthy advance in diagnostic imaging of the GI tract’’ since the development of endoscopic US.1 In the time since, OCT has continued to develop, with a steady stream of articles describing applications and improvements. However, use of OCTremains largely investigational, and most studies involve technology not suitable for endoscopic delivery. Will gastroenterologists ever push the ‘‘OCT button’’ on their endoscopes to obtain clinically actionable images? What is the state of ... (Read Full Article)

      Comment on Article

    19. LightLab Imaging Receives Prism Award

      Explore Article Optical Coherence Tomography News (Jan 27 2010) Cardiology , Other Business News

      LightLab Imaging Receives Prism Award Westford, MA, January 27, 2010 – LightLab Imaging Inc., the pioneer and leader in the development of Optical Coherence Tomography (OCT) for vascular and other imaging applications, today announced the receipt of the Prism Award for Photonics Innovation in the life sciences category. This award was presented by Laurin Publishing and SPIE during SPIE Photonics West on January 27, 2010 to honor photonics innovation. Awards were presented to nine other products in eight other categories. “It is an honor to be recognized by SPIE with this Prism Award.” said Joe Schmitt, Chief Technology Officer of LightLab Imaging. “This shows how ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   Lightlab C7 XR OCT Imaging System   Joseph M. Schmitt

    20. See all featured articles >>

  3. Recent Articles From Around The Web

    1. Method and device for wave-front sensing

      Explore Article PatFT » Page 1 of 1 (4 hours, 31 min ago) Patents

      Method and device for wave-front sensing A method for sensing a wave-front of specimen light scattered from an illuminated area in a specimen (10) includes the steps of focusing illumination light into the specimen (10), directing specimen light scattered in the specimen (10) to a detector device (50) having a plurality of detector elements (51) and being capable to sense light with local resolution, detecting sample light contained in the specimen light with the detector device (50), said sample light being scattered in a predetermined sample plane (11) of the specimen (10) and being selected by a time-based gating of the specimen light, locally resolved measuring ... (Read Full Article)

      Comment on Article

    2. Colorimetric three-dimensional microscopy

      Explore Article PatFT » Page 1 of 1 (7 hours, 3 min ago) Microscopy , Patents

      Colorimetric three-dimensional microscopy An optically reflective or translucent object (14) can be microscopically imaged in all three dimensions and in true color for observation by a human observer. An interferometric optical setup is employed, using the low temporal coherence of a tunable broad-band light source (10, 20) to resolve the axial dimension, a single opto-mechanical or electronic scanning mechanism for accessing different object depths, and a two-dimensional photo sensor device (15, 34) capable of demodulating the temporally or spatially modulated scanning signals to reconstruct the object's full volume. Three volume scans are carried out sequentially, and the tunable broad-band source (10, 20) is ... (Read Full Article)

      Comment on Article Mentions:   Heliotis AG

    3. Volcano found guilty over OCT breach of contract

      Explore Article HealthImaging.com (12 hours, 58 min ago) Cardiology , Other Business News

      Volcano found guilty over OCT breach of contract A Massachusetts Superior Court For Suffolk County jury has ruled against Volcano and its wholly owned subsidiary, Axsun Technologies, in a breach of contract lawsuit filed by Lightlab Imaging on Jan. 7, 2009. In December 2008, Volcano acquired Billerica, Mass.-based Axsun, which had an agreement to supply tunable lasers to the Westford, Mass.-based Lightlab for use in Lightlab's optical coherence tomography (OCT) imaging products until April 2016, with exclusivity in the field of coronary artery imaging expiring in April 2014, according to Volcano. Since the acquisition, Axsun has continued to supply lasers to Lightlab. The jury found that the contract ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   Axsun Technologies   Volcano

    4. Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy

      Explore Article Archives of Ophthalmology (15 hours, 12 min ago) Ophthalmology

      Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy Over the past decade there has been a rapid evolution in our ability to noninvasively image the living human retina. Of particular interest is adaptive optics (AO), a technique that corrects for the eye's monochromatic aberrations and allows nearly diffraction-limited imaging of the retina.1 There is increasing clinical application of AO imaging2-5 owing to the ability to resolve retinal pathological changes on a cellular level, although the future of AO imaging for clinical diagnosis is not clear. Of particular value in determining the potential diagnostic role of AO are cases in which the standard clinical picture is unclear. Here we ... (Read Full Article)

      Comment on Article Mentions:   University of Wisconsin   Heidelberg Engineering   Bioptigen

    5. Tear Measurement in Prosthetic Eye Users with Fourier-Domain Optical Coherence Tomography

      Explore Article American Journal of Ophthalmology (Feb 7 2010) Ophthalmology

      Purpose: To investigate whether Fourier-domain (FD) optical coherence tomography (OCT) can measure the tear meniscus of anophthalmic patients using prosthetic eyes and to compare the characteristics of normal and artificial eyes.Design: Prospective, nonrandomized, observational case series.Methods: Thirty-one patients who had undergone anophthalmic surgery in 1 eye and had been wearing artificial eyes for more than 6 months were included. Subjects with socket inflammation, contracted sockets, or other known lid disorders were excluded. Patients were asked to complete a questionnaire regarding their demographic status and dry eye symptoms before treatment, and FD OCT scanning and the Schirmer test were performed. Three ... (Read Full Article)

      Comment on Article Mentions:   Yonsei University

    6. Observations by Spectral-Domain Optical Coherence Tomography Combined with Simultaneous Scanning Laser Ophthalmoscopy: Imaging of the Vitreous

      Explore Article American Journal of Ophthalmology (Feb 7 2010) Ophthalmology

      Purpose: To determine the ability to detect normal vitreous structure, evolving posterior vitreous detachment (PVD), and related vitreoretinal changes with combined spectral-domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO).Design: Observational cross-sectional study.Methods: Simultaneous SD-OCT and SLO imaging instruments (SD-OCT/SLO) were used to image both eyes of patients with symptoms of PVD. The vitreous cortex, preretinal lacunae, hyaloid, and its relations to the retinal surface were analyzed. In addition, ultrasound was performed in a subset of patients to determine the stage of PVD.Results: Two-hundred two eyes of 113 subjects were scanned. There was a high correlation between diagnosis of ... (Read Full Article)

      Comment on Article Mentions:   William R. Freeman   UCSD   Francesca Mojana

    7. Feature Of The Week 2/7/10: Manual-Scanning Optical Coherence Tomography (OCT) Probe Based on Position Tracking

      Explore Article Optical Coherence Tomography News (Feb 6 2010) Probes

      Feature Of The Week 2/7/10: Manual-Scanning Optical Coherence Tomography (OCT) Probe Based on Position Tracking Feature Of The Week 2/7/10: Optical Coherence Tomography (OCT) is now an important modality in the field of biomedical imaging for its high resolution and non-invasive nature. People have been developing OCT endoscopes to penetrate into deep biological tissues and extend the limited light penetration depth in near infrared wavelength region. Different ways of steering the probing beam have been developed over the years. As most of them need some form of mechanical actuation, they usually come with the associated cost of additional hardware that must be integrated onto the probes. An OCT probe that can be manually swept over ... (Read Full Article)

      Comment on Article Mentions:   California Institute of Technology   Changhuei Yang   Jian Ren

    8. Diagnostic capability of macular parameters of Stratus OCT 3 in detection of early glaucoma

      Explore Article BJO Online (Feb 5 2010) Ophthalmology

      Aim To report the diagnostic capability of Stratus OCT macular parameters in early glaucoma. Material and methods In a cross-sectional observational study, two groups of subjects (early glaucoma and normals) who satisfied the inclusion and exclusion criteria were recruited. The diagnosis of early glaucoma was based on a glaucomatous appearance of the optic disc correlating with visual-field defects (fulfilling at least two of three Anderson and Patella criteria, with a mean deviation better than or equal to −6 dB. All patients underwent a complete ophthalmic evaluation including visual-field examination (24−2/30−2 SITA standard programme) and imaging with Stratus OCT 3. The ... (Read Full Article)

      Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

    9. Retinal Nerve Fiber Layer Thickness After a Single Attack of Primary Acute Angle-Closure Glaucoma Measured With Optical Coherence Tomography

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      BACKGROUND AND OBJECTIVE After a single unilateral acute primary angle-closure glaucoma attack, retinal nerve fiber layer (RNFL) may be thinned. The current study measured the RNFL thickness using optical coherence tomography in eyes with normal visual fields after recovery from a single attack of acute primary angle-closure glaucoma. PATIENTS AND METHODS Twenty-one patients and age-matched control subjects underwent optical coherence tomography scanning after recovery from a single unilateral acute primary angle-closure glaucoma attack. Data from the affected eyes, normal fellow eyes, and control subjects were compared. RESULTS Average RNFL thickness was 91.3 ± 16.4 µm in the affected eyes, 100.1 ... (Read Full Article)

      Comment on Article

    10. Boundary Detection Errors on Optical Coherence Tomography Images in Patients With Diabetic Retinopathy

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      BACKGROUND AND OBJECTIVE To study the incidence of boundary detection errors produced by optical coherence tomography measurements in patients with diabetic retinopathy. PATIENTS AND METHODS One hundred sixteen eyes with diabetic retinopathy of 64 consecutive patients with diabetes mellitus were included in this retrospective study. The StratusOCT instrument (Carl Zeiss Meditec, Dublin, CA) with the macular thickness map protocol was used for the examinations. After data acquisition, each scan was analyzed using the retinal thickness (single eye) protocol to evaluate whether there was any misdetection of the retinal boundaries. RESULTS Boundary detection errors were found in 35.3% of eyes. The ... (Read Full Article)

      Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

    11. Characteristics of Optic Nerve Head Drusen on Optical Coherence Tomography Images

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      BACKGROUND AND OBJECTIVE To describe the characteristics of optic nerve head drusen in optical coherence tomography (OCT) images. PATIENTS AND METHODS Cross-sectional images of the optic nerve were obtained in seven patients with optic nerve head drusen with Stratus and spectral-domain OCT (Carl Zeiss Meditec, Dublin, CA). These were compared to optic disc photographs, autofluorescence, and echography images. For comparison, these tests were performed on four patients with papilledema and three patients with small optic discs. RESULTS Optic nerve head drusen typically elevated the disc surface and appeared as an optically empty cavity, sometimes with a perceptible reflection from the ... (Read Full Article)

      Comment on Article Mentions:   Zeiss Stratus OCT   University of Miami   Carl Zeiss Meditec

    12. Optical Coherence Tomography Findings in Patients With Retinitis Pigmentosa and Low Visual Acuity

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      BACKGROUND AND OBJECTIVE To study the morphological features of the macula of patients with retinitis pigmentosa and visual acuities of 20/200 or less as examined by optical coherence tomography. PATIENTS AND METHODS In an observational case series study, 42 eyes (21 patients) with retinitis pigmentosa and visual acuities of 20/200 or less were evaluated by optical coherence tomography. RESULTS Thirty-four (81%) eyes had atrophic retina (group 1) and 8 (19%) eyes had cystoid macular edema (group 2). The mean visual acuity was 20/1000 in group 1 and 20/300 in group 2. Epiretinal membrane was identified in 27 (64.3%) eyes. CONCLUSION ... (Read Full Article)

      Comment on Article Mentions:   University of Athens

    13. Intraoperative OCT of a Full-Thickness Macular Hole Before and After Internal Limiting Membrane Peeling

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      A child with a traumatic full-thickness macular hole was imaged perioperatively using spectral-domain optical coherence tomography (SD-OCT). Intraoperative imaging using a portable SD-OCT device equipped with a handheld probe demonstrated the full-thickness macular hole to be nearly completely closed following vitrectomy and internal limiting membrane peeling. Air was used as a tamponade agent and prone positioning was used postoperatively for 2 days. SD-OCT imaging confirmed closure of the full-thickness macular hole 5 days and 1 month postoperatively. (Read Full Article)

      Comment on Article Mentions:   Marco B. Ruggeri   University of Miami

    14. Optical Coherence Tomography: A New Tool for Intraoperative Decision Making

      Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

      Optical coherence tomography (OCT) has traditionally been used in the outpatient environment as an important diagnostic tool for retinal clinical decision making. Recent advances in OCT technology have made intraoperative use of OCT feasible. (Read Full Article)

      Comment on Article Mentions:   Carmen A. Puliafito   Keck School of Medicine

    15. Biometry of the Cornea and Anterior Chamber in Chinese Eyes: an Anterior Segment Optical Coherence Tomography Study

      Explore Article iovs.org (Feb 5 2010) Ophthalmology

      Purpose: To investigate the normative data of corneal and anterior segment biometric parameters in Chinese adults and their associations for use in preoperative assessment for corneal and anterior segment surgery. Methods: This cross-sectional, population based study included 750 subjects aged 50 years. The subjects underwent an ophthalmic examination including imaging using anterior segment optical coherence tomography (AS-OCT). Dimensions were subsequently measured with the Zhongshan Assessment Program (ZAP). We also include posterior corneal arc length (PCAL), a novel parameter defined as the arc distance between scleral spurs on the posterior border of the cornea. Correlations with age, gender, height, weight, body ... (Read Full Article)

      Comment on Article Mentions:   Singapore Eye Research Institute   Sun Yat-Sen University

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