1. Recent Articles From Around The Web

    1. An Optical Coherence Tomography Angiography Study

      An Optical Coherence Tomography Angiography Study

      Purpose: To investigate vascular perfusion and foveal avascular zone area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) after intravitreal aflibercept therapy in central retinal vein occlusion eyes and their association with best-corrected visual acuity. Methods: Thirty-five subjects with central retinal vein occlusion and macular edema were evaluated. After macular edema resolution following intravitreal aflibercept , subjects underwent optical coherence tomography angiography to measure SCP and DCP perfusion and the foveal avascular zone within a 3 × 3-mm area. Correlations between best-corrected visual acuity and optical coherence tomography angiography measurements were examined. Results: After intravitreal aflibercept therapy, mean retinal ...

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    2. A Novel Intraoperative Optical Coherence Tomography Feature Predicting Macular Hole Closure

      A Novel Intraoperative Optical Coherence Tomography Feature Predicting Macular Hole Closure

      Purpose: To describe a novel intraoperative finding during pars plana vitrectomy for macular hole using operating microscope-integrated spectral domain optical coherence tomography that predicts the closure of macular hole . Methods: Twenty-five eyes of 25 patients with macular hole , who underwent 25-gauge pars plana vitrectomy over a period of 16 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. All eyes were assessed with intraoperative spectral domain optical coherence tomography before and after internal limiting membrane peeling. The patients were assessed in terms of best-corrected visual acuity, preoperative minimal hole diameter, and ...

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    3. Spectral-Domain Optical Coherence Tomography Findings in Patients With Macropsia

      Spectral-Domain Optical Coherence Tomography Findings in Patients With Macropsia

      BACKGROUND AND OBJECTIVE: To evaluate the retinal morphologic characteristics of patients with macropsia caused by epiretinal membrane (ERM) based on spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: A cross-sectional, non-interventional study was performed to compare the characteristics of retinal structures in eyes with ERM according to the presence or absence of macropsia. Twenty-six patients with ERM and macropsia were defined as the macropsia group and 26 age-matched patients with ERM without macropsia were the control group. All participants underwent a full ophthalmologic examination and SD-OCT examination. Macropsia was diagnosed and quantified using a double dot chart. The thickness of ...

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    4. Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: an optical coherence tomography angiography study

      Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: an optical coherence tomography angiography study

      Retinopathy in systemic lupus erythematosus (SLE) has an incidence of 7%–29% and is suggestive of high disease activity being a marker of poor visual outcome and prognosis for survival. 1 Recently, we demonstrated a subclinical retinal involvement in patients with SLE that seems to be related to kidney involvement where hydroxychloroquine had a protective role. 2 The pathogenesis of lupus retinopathy is attributed to a vasculopathy most commonly immune complex-mediated microangiopathy. 1 Optical coherence tomography angiography (OCTA) is a non-invasive technique for imaging the microvasculature of the retina and choroid that may quantify foveal avascular zone, non-perfused or low-perfused ...

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    5. Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

      Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

      Purpose To characterize the features of choroidal neovascularization (CNV) secondary to angioid streaks (AS) with optical coherence tomography angiography (OCT-A) and to assess its sensitivity in CNV detection in this particular context. Methods Consecutive patients, both with treatment-naïve and recurrent CNV associated with angioid streaks were prospectively analyzed. All patients underwent macular imaging by fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain (SD)-OCT, and OCT-A (AngioVue, Optovue, Optovue Inc., Freemont, CA, USA). OCT-A detection rate of CNV associated to AS was evaluated by two independent observers. We studied the association between OCT-A feature and either exudative or active ...

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    6. Early restenosis of resorbable magnesium scaffolds: Optical coherence tomography findings

      Early restenosis of resorbable magnesium scaffolds: Optical coherence tomography findings

      Resorbable Magnesium Scaffolds (RMS) represent an interesting alternative to current drug‐eluting stents. Current data from clinical trials seems to confirm good performance of these new devices with low rates of late device failure. Little is known about mechanisms leading to RMS failure. Herein, we present the first description of an early RMS in‐scaffold restenosis. Optical coherence tomography (OCT) analysis at implantation detected acute non‐severe malapposition and underexpansion as main promoters of RMS failure. OCT during in‐scaffold restenosis intervention confirmed early severe neointimal proliferation and RMS late recoil and dismantling as the main mechanisms of device failure ...

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      Mentions: Fernando Alfonso
    7. Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Optical coherence tomography (OCT) is a rapid non‐invasive imaging technique that has shown high sensitivity for intraoperative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from excised canine soft tissue sarcoma (STS) and to establish image evaluation criteria for identifying positive surgical margins. Fourteen client‐owned dogs underwent surgical resection of a STS and OCT imaging of 2‐4 areas of interest on the resected specimen were performed. Following ...

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    8. Optic nerve head morphology in primary open‐angle glaucoma and nonarteritic anterior ischaemic optic neuropathy measured with spectral domain optical coherence tomography

      Optic nerve head morphology in primary open‐angle glaucoma and nonarteritic anterior ischaemic optic neuropathy measured with spectral domain optical coherence tomography

      Purpose Optic nerve head (ONH) parameters as well as circumpapillary retinal nerve fibre layer (RNFL) thickness values measured with two different spectral domain optical coherence tomography (SD‐OCT) machines (Spectralis ® and Cirrus ® OCT) have been compared between two patient groups, primary open‐angle glaucoma (POAG), nonarteritic anterior ischaemic optic neuropathy (NAION) and healthy controls. A comparison of the performance of the two OCT machines was made. Methods Twenty healthy controls, 20 POAG and 20 NAION patients with comparable visual field defects were included. Comparison between groups was made using anova and post hoc t ‐tests. To evaluate the diagnostic power ...

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    9. Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air‐puff optical coherence tomography and corneal hysteresis

      Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air‐puff optical coherence tomography and corneal hysteresis

      Application of the air‐puff swept source OCT (SS‐OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air‐puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time‐evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well‐controlled IOP levels and for the progression of ...

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    10. A patient with multiple Swiss cheese aspect coronary lesions: optical coherence tomography to guide coronary angioplasty

      A patient with multiple Swiss cheese aspect coronary lesions: optical coherence tomography to guide coronary angioplasty

      Although spontaneous recanalization of coronary thrombi has been reported pathologically, it is rarely recognized in clinical practice. We presented a rare case of recanalized thrombi of the right coronary artery and distal left anterior descending artery in a patient with an anterior ST segment elevation myocardial infarction treated with primary percutaneous intervention of the proximal left anterior descending artery. Optical coherence tomography aspect of right coronary artery was consistent with a ‘Swiss cheese’ appearance that represented recanalization of organized thrombi. Optical coherence tomography has been essential to discriminate the underlying mechanism and may provide useful information for an appropriate treatment ...

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    11. Preoperative spectral-domain optical coherence tomography in cataract surgery

      Preoperative spectral-domain optical coherence tomography in cataract surgery

      We read with interest the article by Abdelmassih et al.1 regarding the role and cost-effectiveness of preoperative spectral-domain optical coherence tomography (SD-OCT) in patients having cataract surgery. In their study, the macular SD-OCT was abnormal in 26.7% of eyes overall and in 17.5% of eyes when only anomalies not seen on fundus examination were taken into consideration.1 These results are somewhat different from those in previous studies reporting only pathological macular findings in patients having routine cataract surgery.

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    12. Changes in retinal vasculature after phacoemulsification evaluated using optical coherence tomography angiography

      Changes in retinal vasculature after phacoemulsification evaluated using optical coherence tomography angiography

      Zhao et al. 1 describe changes in retinal vessel density and foveal avascular zone area after routine cataract surgery. These parameters were evaluated using optical coherence tomography (OCT) angiography, an exciting new imaging technology for noninvasive evaluation of the retinal microvasculature. 2 It has been reported that the foveal avascular zone, both in the superficial and deep retinal capillary plexus, varies significantly in size, even in normal healthy adults. 3

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    13. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging to guide Vis-OCT imaging and monitor the dynamic cerebral blood flow (CBF). Vis-OCT offers depth-resolved angiography and oxygen saturation (sO 2 ) measurements. Results: Our results showed detailed CBF and vasculature ...

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    14. Alterations of Hyaluronan Metabolism in Acute Coronary Syndrome: Implications for Plaque Erosion

      Alterations of Hyaluronan Metabolism in Acute Coronary Syndrome: Implications for Plaque Erosion

      Background Superficial erosion currently causes at least one-third of acute coronary syndromes (ACS), and its incidence is increasing. Yet, the underlying mechanisms in humans are still largely unknown. Objectives The authors sought to assess the role of hyaluronan (HA) metabolism in ACS. Methods Peripheral blood mononuclear cells were collected from ACS (n = 66), stable angina (SA) (n = 55), and control (CTRL) patients (n = 45). The authors evaluated: 1) gene expression of hyaluronidase 2 (HYAL2) (enzyme degrading high-molecular-weight HA to its proinflammatory 20-kDa isoform) and of CD44v1, CD44v4, and CD44v6 splicing variants of HA receptor; and 2) HYAL2 and CD44 protein ...

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      Mentions: Rocco Vergallo
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  2. Organizations in the News

    1. (2 articles) Nicolaus Copernicus University
    2. (1 articles) UCSF
    3. (1 articles) Duke University
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    6. (1 articles) Massachusetts General Hospital
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  3. People in the News

    1. (1 articles) Ruikang K. Wang
    2. (1 articles) Srinivas R. Sadda
    3. (1 articles) Fernando Alfonso
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    5. (1 articles) David D. Sampson
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    12. (1 articles) Giuseppe Querques
    13. (1 articles) Jon Holmes
    14. (1 articles) Marina Marjanovic
    15. (1 articles) Stephen A. Boppart
  4. OCT Companies in the News

    1. (2 articles) Carl Zeiss Meditec
    2. (1 articles) Optovue
    3. (1 articles) Optopol Technology
    4. (1 articles) Opticent Health
    5. (1 articles) Michelson Diagnostics
    6. (1 articles) Canon Medical Systems
  5. Picture Gallery

    Northeast Symposium on Biomedical Optics to be Held October 24th, 2018 Professor Andrzej Kowalczyk Celebration Gala The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz Heidelberg Engineering OCT Angiography Module Now Available in the United States Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia OCT Promising as Clear Point-of-Care Solution First workshop on artificial intelligence applied to retinal image analysis, Perth Australia, December 2018.
  6. Recent Quotes

    1. The addition of OCT angiography to Heidelberg’s SPECTRALIS multimodal platform allows for the evaluation of retinal and choroidal vascular abnormalities in a noninvasive manner...I believe OCTA will soon become invaluable in our daily clinical routine for screening and diagnosing chorioretinal disorders.”
      By Nadia K. Waheed
    2. We will create this hybrid microscope putting these two powerful technologies together. OCT will image the development of the neural tube while at the same time, Brillouin spectroscopy will probe its mechanical properties. We will be imaging and sensing at the same time...If we find out what causes the tube to close, what is exactly happening, we can develop new drug treatments for at-risk embryos...It's still one of the great mysteries of life, no one on earth knows how this happens and that is really exciting to us, because we will be the ones to find out.
      By Kirill V. Larin
    3. The purported advantages of the synergistic information that IVUS and OCT can provide have been highly anticipated in the interventional cardiology community...These cases performed in Hamilton represent the first worldwide clinical use of any system that combines IVUS with OCT on a single catheter. In an era of personalized and precision medicine, we believe that the ability to collect comprehensive imaging data in patients with coronary artery disease (CAD) provides an important opportunity to generate improved clinical decision-making capabilities for these patients in the future.
      By Brian K. Courtney
    4. The Ganymede series has proven to be an excellent tool for a multitude of imaging applications,...The Thorlabs OCT application team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    5. I am honored and incredibly excited to take on this leadership role during such a pivotal point in the company’s history and look forward to working with Merit Medical on our new strategic partnership. I would like to extend my sincere thanks to Chris for his service to NinePoint and mentorship to me over the past four-years. I am fortunate to be surrounded by a truly talented team with exciting and innovative products in the pipeline. Together, we look forward to continuing our important mission towards early detection of cancer.
      By Eman Namati
    6. We are thrilled to receive marketing clearance for our innovative AngioAnalytics technology as part of the AngioVue System to aid physicians in the early detection and management of sight-threatening eye diseases in the U.S.,” said Jay Wei, founder and chief executive officer of Optovue. “Analytic measurement tools will shift the treatment paradigm because they provide an objective measure of treatment efficacy, thereby enabling truly customized patient management and improved patient care...The information provided by AngioAnalytics may help to change the clinical management of diabetic retinopathy, age-related macular degeneration and other diseases that progressively cause blindness for millions of people. We will continue to advance AngioAnalytics as we believe quantification is the gateway to widespread and global adoption of OCTA.
      By Jay Wei
    7. This is the world's first intravascular imaging system for clinical use with the capability to acquire both IVUS and OCT images using a single catheter. IVUS and OCT are the two most commonly used intravascular imaging technologies in addition to angiography...The Novasight Hybrid System provides the resolution and contrast of OCT with the larger field of view of IVUS, and displays the images in a precisely co-registered fashion.
      By Brian K. Courtney
    8. We started with middle ear infections because of our personal experience with this disease as both parents and patients. Our novel application of optical coherence tomography revolutionizes the diagnosis, treatment and monitoring of the middle ear infections that affect 80% of children.
      By Ryan L. Shelton
    9. With the assistance of the next generation Pantheris system, we helped restore blood flow within the previously blocked segment of the artery and most importantly achieved a great outcome for the patient.
      By Arne G. Schwindt
    10. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen