1. Feature Of The Week

    In the past few decades, OCT has been applied in a wide range of applications including clinical and material research areas. For some biomedical applications such as surgical guidance, real-time volumetric OCT (4D-OCT) imaging is in high demand. However, for high definition volumetric imaging in real time, i.e., 1000 pixels along 3 spatial dimensions and 30 volumetric imaging per second, the data flow will be 1000×1000×1000×30=30GVoxel/s. To process these massive data is a big challenge to the performance of current GPUs and CPUs. Professor Ping Xue, Postdoc Xiao Zhang and their colleagues from Tsinghua University in China, have made important progress to solve the problem. They have found a new way to implement the optical processing of optical spectrum and therefore optically solve the big challenge of massive data processing by GPUs and CPUs. In their paper, they reported a novel optical computing technique for high speed real-time OCT, as called OC-OCT or OC2T. Different from traditional FD-OCT, the interpolation in the wavenumber domain and FFT by GPU or CPU are not needed any more in OC2T. Instead of software algorithm and GPUs computing, they employed an all-optical real-time Fourier transformation system to process the A-scan data before the OCT light signal was converted to electrical signal by the photodetector. Using this optical computing technique, the A-scan rate and A-scan processing speed of OC2T have reached 10 mega-A-scans/second in their experiment, which is the fastest real-time sampling and processing speed to date. Furthermore, OC2T based on the all-fiber configuration is much more stable and easier to be used. The OC2T is able to be fast enough to achieve the video rate 4D-OCT imaging at a large volume size and therefore further enable the real-time virtual reality, which is of great value in surgical guidance. It is believed that this new technology will initiate new development of ultra-fast OCT technology.

    For more information see recent Article. Courtesy Ping Xue from Tsinghua University. To share this article click Here.

  2. Recent Articles From Around The Web

    1. The challenge to detect and to treat vulnerable plaques and vulnerable patients

      The challenge to detect and to treat vulnerable plaques and vulnerable patients

      One of many “holy grails” of cardiology is to avoid the occurrence of acute coronary syndromes (ACS). It would be a remarkable improvement in the field if we could develop the capacity to identify the spots of the coronary vessels that are about to become unstable during the following weeks or months. This should be possible if we were able to prevent dissection, rupture or erosion of the coronary wall which usually causes an ACS [1-3]. It is said that this could possibly be realized by identifying those unstable coronary artery lesions that are more prone to result in future ...

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    2. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s, and thus, both 3D volumetric images, reaching up to 20mm × 20mm × 1.2mm, and en face internal fingerprint furrow pattern images could be obtained. Based upon the analyses of the ...

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    3. Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

      Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

      Aim: To image the radial peripapillary capillary (RPC) network with optical coherence tomography angiography (OCTA) and measure its capillary density (CD) in the normal human retina. Materials and Methods: Fifty-two normal participants underwent OCTA imaging with RTVue XR 100 Avanti OCT. The angioflow enface RPCs network was extracted from OCTA and 8 peripapillary sectors with a sector angle of 45 degrees were selected for quantitative analysis: superior nasal, superior temporal, temporal upper, temporal lower, nasal upper, nasal lower, inferior nasal, and inferior temporal. CD was measured within a 3.4-mm circle diameter around the optic nerve head (ONH) using the ...

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    4. Full-range ultrahigh-resolution spectral-domain optical coherence tomography in 1.7 µm wavelength region for deep-penetration and high-resolution imaging of turbid tissues

      Full-range ultrahigh-resolution spectral-domain optical coherence tomography in 1.7 µm wavelength region for deep-penetration and high-resolution imaging of turbid tissues

      For the first time, we developed a full-range ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) technique working in the 1.7 µm wavelength region. This technique allowed high-resolution, deep-tissue imaging. By using a supercontinuum source operating at a wavelength of 1.7 µm, an axial resolution of 3.6 µm in a tissue specimen was achieved. To enhance the imaging depth of UHR-SD-OCT, we performed full-range OCT imaging based on a phase modulation method. We demonstrated the three-dimensional (3D) imaging of a mouse brain with the developed system, and specific structures in the mouse brain were clearly visualized at depths ...

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    5. Green disease in optical coherence tomography diagnosis of glaucoma

      Green disease in optical coherence tomography diagnosis of glaucoma

      Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression.Recent findings: Conditions in which OCT color coding may be falsely negative (i.e., green disease) are identified. Early glaucoma in which retinal nerve fiber layer (RNFL) thickness and optic disc parameters, albeit labeled green, are asymmetric in both eyes may result ...

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      Mentions: Richard K. Lee
    6. En Face Optical Coherence Tomography of Cystoid Macular Edema

      En Face Optical Coherence Tomography of Cystoid Macular Edema

      The honeycomb pattern of large and small cystoid abnormalities in the segmented en face swept-source optical coherence tomography (SS-OCT) section through the outer plexiform and inner nuclear layers of the retina is depicted in Figure , A. Intraretinal cystoid spaces in the conventional B-scan SS-OCT image are shown in Figure , B. The en face reconstruction demonstrates the exact nature, extent, and anatomical configuration of the pathology. Cystoid macular edema is a common sequela of intraocular inflammation resulting from many causes like intermediate uveitis and cataract surgery. The commercially available SS-OCT imaging technology has an axial resolution as high as 1 µm ...

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    7. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100′000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies. The optical properties of the eye allow the imaging of the ...

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    8. Selected Topics in Optical Coherence Tomography (Textbook)

      Selected Topics in Optical Coherence Tomography (Textbook)

      This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.

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      Mentions: Gangjun Liu
    9. Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Purpose : To evaluate the effects of phacoemulsification cataract surgery on Schlemm's canal (SC) using swept-source optical coherence tomography (OCT). Methods : Patients with a senile cataract were included. The SC area and diameter were checked by OCT at the baseline and 1 day, 1 week, 1 month, and 6 months after the cataract surgery. Multivariate linear regression analysis was performed for predictors of change in the mean SC area and diameter. Results : Twenty-five eyes (25 patients) were included in the final analysis. After the cataract surgery, there was a significant increase in the SC area and diameter, and a decrease ...

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    10. In Vivo optical coherence tomography visualization of intraplaque neovascularization at the site of coronary vasospasm: a case report

      In Vivo optical coherence tomography visualization of intraplaque neovascularization at the site of coronary vasospasm: a case report

      Background Coronary plaques in patients with coronary vasospastic angina have been characterized by diffuse intima-media thickening with homogeneous fibrous tissue, without confluent necrotic tissue. However, coronary vasospasm can trigger coronary thrombosis, and may play an important role in the pathogenesis of acute coronary syndromes, though the precise morphological mechanisms underlying this process remain unclear. Case presentation A 43-year-old man with a history of multivessel coronary vasospastic angina had been treated with long-acting diltiazem and fluvastatin since 2004. Eleven years later, following 1 month of medication nonadherence, he experienced recurrence of rest angina and myocardial infarction, with elevated high-sensitivity troponin T ...

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    11. Optical Coherence Tomography (OCT) Intravascular Ultrasound (IVUS) Dual Imaging

      Optical Coherence Tomography (OCT) Intravascular Ultrasound (IVUS) Dual Imaging

      Both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are standardly used and have been extensively studied separately to guide percutaneous coronary intervention and improve long-term outcomes. In this study, the investigators aim to directly compare high-definition IVUS images to OCT in the same patients to determine the differences between each modality as they relate to imaging coronary pathology, with the goal of determining which modality is most appropriate in particular clinical scenarios.

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    12. Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Purpose To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. Methods This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. Results Percentages of non-gradable images for the outline of foveal avascular zone ...

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    13. Temporal ocular coherence tomography-measured changes in anterior chamber angle and diurnal intraocular pressure after laser iridoplasty: IMPACT study

      Temporal ocular coherence tomography-measured changes in anterior chamber angle and diurnal intraocular pressure after laser iridoplasty: IMPACT study

      Aims To evaluate temporal change in anterior chamber angle anatomy following argon laser peripheral iridoplasty (ALPI) in eyes with occludable angles postlaser peripheral iridotomy (LPI) compared with control eyes. Additionally, the effect on diurnal intraocular pressure (DIOP) fluctuation (maximum-minimum IOP) was investigated. Methods Twenty-two patients with bilateral primary angle closure/suspects with gonioscopically occludable anterior chamber angles following LPI were randomised to receive ALPI (n=11) or no further treatment (n=11). Angle opening distance (AOD), trabecular-iris angle, angle recess area and trabecular-iris space area were measured over eight sections with swept-source anterior segment optical coherence tomography and DIOP was ...

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    14. Correlation between clinical, fluorescein angiography and optical coherence tomography findings in clinically significant macular edema

      Correlation between clinical, fluorescein angiography and optical coherence tomography findings in clinically significant macular edema

      Background: Macular edema is an important cause of visual morbidity in diabetic retinopathy. It can be assessed by both fluorescein angiography (FA) and optical coherence tomography (OCT). Aims: To study, if any, correlation exists between FA and OCT patterns in Clinically significant macular edema (CSME). Furthermore, to correlate macular thickness as determined by OCT to best-corrected visual acuity (BCVA). Materials and Methods: This was a prospective study which compared patterns in FA and OCT in patients with CSME. All the patients who were diagnosed as CSME underwent a complete ophthalmic examination and were subjected to FA and OCT. Those with ...

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    15. Limbal Stem Cell Preservation During Proton Beam Irradiation for Diffuse Iris Melanoma

      Limbal Stem Cell Preservation During Proton Beam Irradiation for Diffuse Iris Melanoma

      Purpose: To report the outcome after limbal stem cell preservation during proton beam irradiation for diffuse iris melanoma. Methods: This is a single-case report of diffuse iris melanoma that was managed with proton beam radiation (53 Gy), wherein preemptively harvested superior and inferior limbal stem cells before radiation were replaced after irradiation. Regeneration of the palisades of Vogt and the limbal stem cells was documented by an optical coherence tomography–based imaging protocol. Results: At 24 months after radiation therapy, best-corrected visual acuity was 20/25. The cornea was clear without evidence of limbal stem cell dysfunction. Clinical examination (including ...

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      Mentions: William J. Dupps
    16. See all articles
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    Adaptive optics optical coherence tomography in glaucoma Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users OCT Expanded Clinical Data Analysis (OCT Aboard Space Station) Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography Optical Modalities for Embryonic Imaging High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source Plasma treatment effect on angiogenesis in wound healing process evaluated in vivo using angiographic optical coherence tomography A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration Postdoctoral Position in Optical Coherence Tomography / Optical Coherence Elastography at University of Houston Classification and analysis of human ovarian tissue using full field optical coherence tomography
  6. Recent Quotes

    1. We believe strongly that our MRO™ sub-dermal fingerprint technology can play a key role in addressing the presentation attack problem by providing an effective deployable solution.
      By Don Bogue
    2. Today, interdisciplinary research in biomedical optics is the standard. “And that was less common 25 years ago. A lot of innovation happens at the boundaries of disciplines. OCT is such a rich combination of disciplines—in optics, mechanical systems, electronics, software, medical devices, clinical medicine. That’s one of the reasons there’s been so much innovation in OCT, and that there’s so much more to come.
      By Eric A. Swanson
    3. We are excited to bring to market groundbreaking technologies that provide valuable new, detailed information about the microvasculature of the eye, in a manner that reduces the burden for both the patient and the clinic staff...DualTrac Motion Correction allows for improved imaging and quicker data collection to further the clinical utility of OCTA technology by accommodating natural eye movement.
      By Jay Wei
    4. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      By David Huang
    5. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      By Wolfgang Drexler
    6. This gives us a very controlled way of looking at ovarian cancer.
      By Jennifer K. Barton
    7. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      By Jennifer K. Barton
    8. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    9. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
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      By Nishant Mohan