1. Featured Articles

    1. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      Explore OSA | OSA Publishing
      Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      We report the use of an electrically tunable lens (ETL) in a 1.3 μm spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral blood flow imaging of all cortical layers by stitching the OCTA images automatically captured at six focal depths. Capillary vasculature and axial blood flow velocity were revealed in distinctive cortical ...

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      Mentions: University of Washington Ruikang K. Wang

    2. Metasurface-based focus-tunable mirror

      Explore OSA | OSA Publishing Probes
      Metasurface-based focus-tunable mirror

      Varifocal mirrors, which have various applications in optical coherent tomography and three-dimensional displays, are traditionally based on the fluid pressure or mechanical pusher to deform the mirror. The limitations of conventional varifocal mirrors are obvious, such as the heavy size of the device and constraints of tunability, due to their mechanical pressure control elements. The reprogrammable metasurface, a new flat photonic device with multifunction in an ultrathin dimension, paves the way towards an ultrathin and lightweight mirror with precise phase profile. Here, an active reconfigurable metasurface is proposed to achieve the manipulation of the wavefront. The meta-atom in the metasurface ...

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    3. Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography”

      Explore Optical Coherence Tomography News Jobs & Studentships
      Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography”

      School of Physical Sciences Location: Canterbury Salary: £32,500 Grade: Marie Curie Post Type: Full Time Contract Type: Fixed Term - 36 Months Release Date: Thursday 10 October 2019 Closing Date: 23.59 hours GMT on Monday 30 December 2019 (unless otherwise stated) Reference: STM-074-19 We are recruiting for three PhD Studentships in the fields of Optics and Laser Physics, with emphasis on optical coherence tomography for a period of 36 months with a start date anytime between 1st February 2020 and 31 January 2021, within the Applied Optics Group, School of Physical Sciences. These are supported by the Marie Curie ...

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      Mentions: Université Pierre et Marie Curie University of Kent

    4. Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission

      Explore Optical Coherence Tomography News
      Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission

      Scientific Reports , a Nature Research journal, is welcoming original primary research articles for a special Guest Edited Collection on ‘Quantitative and computational techniques in optical coherence tomography’ (https://www.nature.com/srep/guestedited#optical-coherence-tomography ). This Collection seeks to bring together original Articles which exploit realistic mathematical models of OCT image formation to obtain insight not otherwise available from raw OCT images. This includes research using techniques such as parametric attenuation imaging, local birefringence retrieval, full-wave modelling, computational adaptive optics, flow and displacement measurement, elastography and inverse scattering. Submissions are welcome on a rolling basis. For information regarding Scientific Reports' policies ...

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      Mentions: University College London Peter R. T. Munro

    5. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      Explore Nature Publishing Group Ophthalmology
      A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient discomfort. Using a custom deep learning network trained with 2,328 ‘clean B-scans’ (multi-frame B-scans; signal averaged), and their corresponding ‘noisy B-scans’ (clean B-scans + Gaussian noise), we were able to ...

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      Mentions: Medical University of Vienna Singapore Eye Research Institute Nanyang Technological University

    6. VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery

      Explore School of Engineering Ophthalmology , Funding
      VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery

      A team of Vanderbilt University engineers and clinicians have won a five-year $1.8 million National Eye Institute grant to develop and translate novel intraoperative imaging technologies to the ophthalmic surgical suite to enable real-time surgical guidance. “Our group has spent quite a few years working on developing the underlying imaging technology,” said Yuankai Kenny Tao, assistant professor of biomedical engineering and a faculty researcher in the Vanderbilt Institute for Surgery and Engineering, is the principal investigator. “This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to ...

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      Mentions: Vanderbilt University Yuankai K. Tao

    7. Advances In Intraoperative OCT

      Explore Review of Ophthalmology® > Home Ophthalmology
      Advances In Intraoperative OCT

      Over the past decade, there have been major advances in the field of intraoperative optical coherence tomography. From the development of the portable OCT probe to the first microscope-integrated system, intraoperative OCT has evolved from a research idea to a clinically viable technology. Advances such as heads-up visualization and microscope-integration, as well as the results from large clinical studies, have pushed the field forward. While the feasibility and potential utility of intraoperative optical coherence tomography has been demonstrated both in clinical studies and in real-world usage, several areas of enhancement are needed to enable iOCT to be part of a ...

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      Mentions: Cleveland Clinic Justis P. Ehlers

    8. Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

      Explore OSA | OSA Publishing Pulmonology
      Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

      We have developed a human bronchial epithelial (HBE) cell and endothelial cell co-cultured microfluidic model to mimic the in vivo human airway. This airway-on-a-chip was designed with a central epithelial channel and two flanking endothelial channels, with a three-dimensional monolayers of cells growing along the four walls of the channel, forming central clear lumens. These cultures mimic airways and microvasculature in vivo . The central channel cells are grown at air-liquid interface and show features of airway differentiation including tight-junction formation, mucus production, and ciliated cells. Combined with novel micro-optical coherence tomography, this chip enables functional imaging of the interior of ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital University of Alabama

    9. Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      Explore Nature Publishing Group NDE/NDT
      Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      The success of reef-building corals for >200 million years has been dependent on the mutualistic interaction between the coral host and its photosynthetic endosymbiont dinoflagellates (family Symbiodiniaceae) that supply the coral host with nutrients and energy for growth and calcification. While multiple light scattering in coral tissue and skeleton significantly enhance the light microenvironment for Symbiodiniaceae, the mechanisms of light propagation in tissue and skeleton remain largely unknown due to a lack of technologies to measure the intrinsic optical properties of both compartments in live corals. Here we introduce ISOCT (inverse spectroscopic optical coherence tomography), a non-invasive approach to measure ...

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      Mentions: Northwestern University

    10. Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial

      Explore interventions.onlinejacc.org Cardiology
      Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial

      Background Fractional flow reserve (FFR) and optical coherence tomography (OCT) may help both in assessment of angiographically-intermediate coronary lesions (AICL) and in percutaneous coronary interventions (PCI) optimization. Objectives: To compare OCT-guidance and FFR-guidance in patients with AICL in a single-center, prospective, 1:1 randomized trial (acronym: FORZA, NCT01824030 ). Methods Patients with AICL were randomized to FFR or OCT. In the FFR arm, PCI was performed if FFR was ≤0.80. In the OCT arm, PCI was performed if area stenosis was ≥75% or 50%-75% with minimal lumen area <2.5 mm 2 or plaque rupture. Angina (evaluated by Seattle ...

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      Mentions: Rocco Vergallo

    11. Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging

      Explore Canadian Journal of Cardiology Cardiology
      Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging

      Background Coronary artery disease leads to progression of pathological formations in arterial wall layers, which may be followed by acute coronary syndrome. Optical Coherence Tomography has high resolution to visualize intracoronary wall structure. In this study, we aimed to design a computer aided diagnostic model providing clinicians with an operator-independent diagnosis of coronary lesions. Jump to Section Background Methods and Results Conclusion Methods and Results 45 OCT pullbacks obtained from different pediatric patients using ILUMIEN OCT system with ∼100 images per pullback are used in this study. Our proposed coronary diagnostic model starts with evaluating the structural changes of the ...

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    12. OCT-Based Tooth Scan and Reconstruction

      Explore MDPI Open Access Journals Platform Dentistry
      OCT-Based Tooth Scan and Reconstruction

      Digital dental reconstruction can be a more efficient and effective mechanism for artificial crown construction and period inspection. However, optical methods cannot reconstruct those portions under gums, and X-ray-based methods have high radiation to limit their applied frequency. Optical coherence tomography (OCT) can harmlessly penetrate gums using low-coherence infrared rays, and thus, this work designs an OCT-based framework for dental reconstruction using optical rectification, fast Fourier transform, volumetric boundary detection, and Poisson surface reconstruction to overcome noisy imaging. Additionally, in order to operate in a patient’s mouth, the caliber of the injector is small along with its short penetration ...

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      Mentions: National Taiwan University National Yang-Ming University

    13. Intravascular optical coherence tomography method for automated detection of macrophage infiltration within atherosclerotic coronary plaques

      Explore atherosclerosis-journal.com Cardiology
      Intravascular optical coherence tomography method for automated detection of macrophage infiltration within atherosclerotic coronary plaques

      Background and aims Significant macrophages infiltration in advanced atherosclerotic plaques promotes acute coronary events. Hence, the clinical imaging of macrophage content in coronary atherosclerotic plaques could potentially aid in identifying patients most at risk of future acute coronary events. The aim of this study was to introduce and validate a simple intravascular optical coherence tomography (IV-OCT) image processing method for automated, accurate and fast detection of macrophage infiltration within coronary atherosclerotic plaques. Methods This method calculates the ratio of the normalized-intensity standard deviation (NSD) values estimated over two axially-adjacent regions of interest in an IV-OCT cross-sectional image (B-scan). When applied ...

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      Mentions: Javier A. Jo

    14. Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group with Dr. Xincheng Yao ( yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Dr. Yao’s Biomedical Optics and Functional Imaging Laboratory is housed in the Lions of Illinois Eye Research Institute (LIERI), within the same building with UIC Retina Clinic. In collaboration with experienced ophthalmologists and vision scientists, our lab is focusing on new development of ophthalmic instrumentation and imaging technology to advance retinal study, disease diagnosis and treatment evaluation. Our current research includes ultra-wide field fundus photography, functional optical coherence ...

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      Mentions: Xincheng Yao

    15. VIS-OCT Opens Eyes to New Approaches

      Explore Photonics.com
      VIS-OCT Opens Eyes to New Approaches

      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map the microvasculature in the eye without contrast agent and is being investigated in clinical ophthalmology.

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      Mentions: Northwestern University Hao F. Zhang Opticent Health

    16. OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      Explore Photonics.com
      OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      This webinar will provide an executive overview for leaders in imaging and ophthalmology on how artificial intelligence (AI) is transforming the field of medical imaging. Presenter Nishant Mohan will provide a hands-on demonstration of how to develop a deep-learning AI system from scratch, giving attendees critical insight into how to use this powerful tool. Separating the hype from reality, Mohan will discuss essential concepts behind the revolutionizing power of AI. In addition, he will present critical factors in the ecosystem that is driving AI technology and major AI platforms. He will provide specific examples of the application of AI in ...

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      Mentions: Wasatch Photonics Nishant Mohan
    17. See all articles

  2. Recent Articles From Around The Web

    1. In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

      Explore SPIE Digital Library Ophthalmology
      In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

      Corneal collagen cross-linking (CXL) strengthens the biomechanical properties of damaged corneas. Quantifying the changes of stiffness due to different CXL protocols is difficult, especially in vivo . A noninvasive elastic wave-based optical coherence elastography system was developed to construct in vivo corneal elasticity maps by excitation of air puff. Biomechanical differences were compared for rabbit corneas given three different CXL protocols while keeping the total energy delivered constant. The Young’s modulus was weaker in corneas treated with higher irradiance levels over shorter durations, and a slight increase of Young’s modulus was present in all groups one week after the ...

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      Mentions: Wenzhou Medical College Meixiao Shen

    2. The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension

      Explore neurores.org Neurology , Ophthalmology
      The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension

      Background: Recently, optical coherence tomography (OCT) has enhanced our understanding of visual disturbances in idiopathic intracranial hypertension (IIH). Its importance in the evaluation process of IIH has been established; however, there are many unknown aspects regarding the relationship of OCT measurements with several clinical features of IIH. Herein, we aimed to investigate the associations of OCT measurements with neuroimaging findings and some clinical parameters in our cohort with IIH. Methods: Patients over 18 years of age presenting to the neurology and neuro-ophthalmology outpatient clinics, between 2017 and 2019, who were diagnosed with IIH were included in the study. Cranial magnetic ...

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    3. Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography

      Explore IOPscience Probes
      Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography

      Endoscopic optical coherence tomography is an interference based imaging technique which due to its micron level resolution ability found several applications in medical diagnostics. However, the standard image performance suffers from artefacts caused by dispersion imbalance and polarisation mismatches between reference and sample arm. Such artefacts can be minimised with the use of a special class of probes called common path probes where the reference surface is placed in the vicinity of the sample. Previously reported common path probes suffered from a compromise between sensitivity and resolution. In most cases, proposed probes were not scalable for industrial applications and required ...

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    4. Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

      Explore Balkan Medical Journal Ophthalmology
      Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

      Background: Optical coherence tomography angiography (OCTA) allows the detailed evaluation of retinal and choroidal microvascular structures with no need for a contrast agent. Pseudoexfoliation (PEX) is a condition that leads to anatomical and functional losses due to the accumulation of degraded abnormal fibrillar material in the intraocular and extraocular tissues. Histopathological studies have shown that the accumulation of PEX material in vascular structures may play a role in different pathologies such as retinal vein occlusion, iris hypoperfusion, anterior segment hypoxia, retinal arterial occlusion, and neovascular glaucoma. Aims: To evaluate and compare flow and vascular density in the retina and choroid ...

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    5. Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Explore ScienceDirect Ophthalmology
      Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Purpose To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I-125) plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design Longitudinal prospective study of 21 subjects undergoing treatment for uveal melanoma with I-125 plaque brachytherapy. Eyes with melanoma were imaged with OCTA prior to treatment and at 12 month intervals until 2 years post-brachytherapy. Participants After IRB-approval, participants were enrolled prospectively from an academic ocular oncology clinic. Patients with low vision of < 20/200 in the eye with tumor at baseline were excluded. Methods Peripapillary (4.5 x 4.5-mm) and macular ...

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      Mentions: David Huang Oregon Health & Science University Yali Jia

    6. Morphometric characteristics of the optical disc and thickness of retinal nerve fibre layer using Cirrus 5000 optical coherence tomography in healthy patients attending the National Institute of Ophthalmology

      Explore ScienceDirect Ophthalmology
      Morphometric characteristics of the optical disc and thickness of retinal nerve fibre layer using Cirrus 5000 optical coherence tomography in healthy patients attending the National Institute of Ophthalmology

      Objective To describe the morphometric characteristics and thickness of the retinal nerve fibre layer (CFNR) in healthy patients using optical coherence tomography. Methods A cross-sectional and descriptive study was conducted on a total of 184 eyes of 184 people of mestizo origin enrolled after a complete ophthalmological evaluation at the National Institute of Ophthalmology, Lima-Peru. The morphometric parameters of the optic disc and thickness of the CFNR were measured by optical coherence tomography ZEISS CIRRUS™ HD-OCT Model 5000 (Carl Zeiss Inc., Dublin, CA, EE.UU). Megalopapilla was defined as: area of the optical disc greater than 2.5 mm 2 ...

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      Mentions: Carl Zeiss Meditec

    7. Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Explore BMC Ophthalmology Ophthalmology
      Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques with a mean age of 4.91 ± 0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean ...

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      Mentions: Optovue Sun Yat-Sen University

    8. Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography

      Explore Home - Springer Cardiology
      Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography

      In this document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application of OCT/OFDI to guide percutaneous coronary interventions.

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      Mentions: Wakayama Medical University Kenichi Fujii Takashi Kubo

    9. Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer

      Explore Journals | PLOS Ophthalmology
      Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer

      Purpose To compare biometry and prediction of postoperative refractive outcomes obtained by two swept-source optical coherence tomography (SS-OCT) biometers (IOLMaster 700 and Argos), and a partial coherence interferometry (IOLMaster ver 5.4) Methods Biometric values were measured using two SS-OCT and PCI device and evaluated against one another. Predictive errors were compared at one month after cataract surgery. Results One hundred forty six eyes were considered. Axial length (AXL) measurements were not successful in 3 eyes measured by IOLMaster 700 and Argos devices, and in 17 eyes measured by IOLMaster ver. 5.4 devices. AXL as measured by Argos showed ...

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      Mentions: Sungkyunkwan University

    10. Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Explore Home - Springer Ophthalmology
      Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Microvascular changes are one of the early symptoms of retinal diseases. Recently developed optical coherence tomography angiography (OCTA) technology allows visualization and analysis of the retinal microvascular network in a non-invasive way. However, automated analysis of microvascular changes in OCTA is not a trivial task. Current approaches often attempt to directly segment the microvasculature. These approaches generally have problems in cases of poor image quality and limited visibility of the vasculature. Evaluating the quality of the results is also challenging because of the difficulty of manually tracing the microvasculature, especially in cases of low image quality or with images with ...

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      Mentions: University of Iowa Randy H. Kardon Mona K. Garvin

    11. Structure-Aware Noise Reduction Generative Adversarial Network for Optical Coherence Tomography Image

      Explore Home - Springer
      Structure-Aware Noise Reduction Generative Adversarial Network for Optical Coherence Tomography Image

      Optical coherence tomography (OCT) is a common imaging examination in ophthalmology, which can visualize cross-sectional retinal structures for diagnosis. However, image quality still suffers from speckle noise and other motion artifacts. An effective OCT denoising method is needed to ensure the image is interpreted correctly. However, lack of paired clean image restricts its development. Here, we propose an end-to-end structure-aware noise reduction generative adversarial network (SNR-GAN), trained with un-paired OCT images. The network is designed to translate images between noisy domain and clean domain. Besides adversarial and cycle consistence loss, structure-aware loss based on structural similarity index (SSIM) is added ...

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    12. Automated detection of glaucoma using optical coherence tomography angiogram images

      Explore ScienceDirect Ophthalmology
      Automated detection of glaucoma using optical coherence tomography angiogram images

      Glaucoma is a malady that occurs due to the buildup of fluid pressure in the inner eye. Detection of glaucoma at an early stage is crucial as by 2040, 111.8 million people are expected to be afflicted with glaucoma globally. Feature extraction methods prove to be promising in the diagnosis of glaucoma. In this study, we have used optical coherence tomography angiogram (OCTA) images for automated glaucoma detection. Ocular sinister (OS) from the left eye while ocular dexter (OD) were obtained from right eye of subjects. We have used OS macular, OS disc, OD macular and OD disc images ...

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      Mentions: Nanyang Technological University Kumamoto University

    13. 3D-CNN for Glaucoma Detection Using Optical Coherence Tomography

      Explore Home - Springer Ophthalmology
      3D-CNN for Glaucoma Detection Using Optical Coherence Tomography

      The large size of raw 3D optical coherence tomography (OCT) volumes poses challenges for deep learning methods as it cannot be accommodated on a single GPU in its original resolution. The direct analysis of these volumes however, provides advantages such as circumventing the need for the segmentation of retinal structures. Previously, a deep learning (DL) approach was proposed for the detection of glaucoma directly from 3D OCT volumes, where the volumes were significantly downsampled first. In this paper, we propose an end-to-end DL model for the detection of glaucoma that doubles the number of input voxels of the previously proposed ...

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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    14. U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography

      Explore Home - Springer Ophthalmology
      U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography

      The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task. In the second approach, the surrounding retinal layers (outer boundary retinal pigment epithelium (OBRPE) and Bruch’s membrane (BM)) are segmented and the remaining space between these two layers is extracted as drusen. In this work, we extend the standard U-Net architecture with spatial pyramid pooling components to introduce global feature ...

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      Mentions: Medical University of Vienna Ursula Schmidt-Erfurth

    15. Optical coherence tomography analysis of inner and outer retinal layers in eyes with chiasmal compression caused by suprasellar tumours

      Explore Wiley Online Library Ophthalmology
      Optical coherence tomography analysis of inner and outer retinal layers in eyes with chiasmal compression caused by suprasellar tumours

      Purpose To compare postoperative macular thickness measurements of inner and outer retinal layers in eyes of patients with chiasmal compression with or without visual field (VF) recovery and healthy controls using optical coherence tomography (OCT). Methods Macular spectral‐domain OCT has been used for the auto‐segmentation of images obtained from 100 eyes affected with chiasmal compression compared with 100 healthy controls enrolled in this study. We have divided eyes with chiasmal compression into two groups: group 1 characterized by VF recovery after tumour excision and group 2 showing partial or no recovery of VF. The thickness of the macular ...

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      Mentions: Sungkyunkwan University
      16. See all articles
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  9. Picture Gallery

    Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice Metasurface-based focus-tunable mirror Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography” Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery Advances In Intraoperative OCT Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging OCT-Based Tooth Scan and Reconstruction

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  12. Recent Quotes

    1. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    2. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
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    4. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    5. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
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    7. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    8. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    9. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    10. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney