1. Featured Articles

    1. PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      Explore Optical Coherence Tomography News Tunable Sources , Jobs & Studentships
      PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      We offer a three year PhD student position for an Early Stage Researcher (ESR) on laser development in biomedical optics. The position is part of a Marie Skłodowska-Curie Innovative Training Network (ITN) within the EU Horizon 2020 Framework Programme. It will be within the project NETLAS (https://cordis.europa.eu/project/id/860807), which focuses on innovative solutions for fast, narrow linewidth, phase stable and wide tuning bandwidth swept sources as well as on their application in biomedical optics - especially for optical coherence tomography (OCT). 

      The position is in the group of Robert Huber at the University of Lübeck ...

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      Mentions: Cordis Robert A. Huber University of Lübeck

    2. Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston

      Applications are invited for a postdoctoral research associate position in the Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) at the University of Houston, TX. The position is supported by National Library of Medicine (NLM) Training Program in Biomedical Informatics and Data Science fellowships. The NLM Training Program in Biomedical Informatics and Data Science is an innovative, inter-disciplinary, and multi-institutional training program that trains at the interface between the computational /mathematical sciences and biological sciences/biomedicine to face the biggest challenges in biomedical informatics and data science today. Our accomplished training faculty, history of collaboration, and the combined resources of ...

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      Mentions: Kirill V. Larin University of Houston

    3. Quantification of plant morphology and leaf thickness with optical coherence tomography

      Explore OSA | OSA Publishing NDE/NDT
      Quantification of plant morphology and leaf thickness with optical coherence tomography

      Optical coherence tomography (OCT) can be a valuable imaging tool for in vivo and label-free digital plant phenotyping. However, for imaging leaves, air-filled cavities limit the penetration depth and reduce the image quality. Moreover, up to now quantification of leaf morphology with OCT has been done in one-dimensional or two-dimensional images only, and has often been limited to relative measurements. In this paper, we demonstrate a significant increase in OCT imaging depth and image quality by infiltrating the leaf air spaces with water. In the obtained high-quality OCT images the top and bottom surface of the leaf are digitally segmented ...

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      Mentions: Thorlabs Jeroen Kalkman Delft University of Technology

    4. Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health

      Explore Patient Care at NYU Langone Health Cardiology
      Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health

      N ew research presented today at the American Heart Association’s Scientific Sessions 2020 found that additional imaging tests can determine the underlying reason for heart attacks in most women without coronary artery narrowing . A correct diagnosis can guide appropriate medical treatment. Led by researchers and clinicians at NYU Grossman School of Medicine, the study examined women with MINOCA, or myocardial infarction with non-obstructive coronary arteries, a condition that accounts for 6 to 15 percent of heart attacks and is 3 times more common among women than men with heart attack. It determined that coronary optical coherence tomography (OCT) and ...

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      Mentions: NYU Langone Medical Center

    5. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      Explore OSA | OSA Publishing Tunable Sources
      Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze ...

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      Mentions: Robert A. Huber University of Lübeck Tom Pfeiffer

    6. Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award

      Explore Optical Coherence Tomography News Other Business News
      Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award

      Cylite Pty Ltd, a developer and manufacturer of 4 th Generation OCT systems for Ophthalmology and Optometry, is honoured to be awarded the Sir William Hudson Award. Australia's highest accolade for an engineering project. The judges citation read “this is a remarkable piece of equipment and demonstrates the profound impact biomedical engineering can have on society. By using 1000’s of light waves to create an accurate and almost instantaneous 3D image of the eye, the equipment streamlines the screening process that currently requires several individual diagnostic devices to build a clinical picture of the patient. This enables more ...

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      Mentions: Cylite

    7. Optical coherence tomography in the 2020s—outside the eye clinic

      Explore Nature Publishing Group Ophthalmology
      Optical coherence tomography in the 2020s—outside the eye clinic

      Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of OCT such as OCT angiography. However, more needs to be done to radically improve the access to OCT by addressing its limitations and enable penetration outside of typical clinical settings ...

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      Mentions: University College London Pearse A. Keane

    8. 8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      Explore Optical Coherence Tomography News Ophthalmology
      8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      More than 50 leading scholars will share their enthusiasm for OCT Angiography and OCT . Highlights of the Congress: scientific and technology session organized by James Fujimoto, Lumbroso Lecture by Larry Yannuzzi, five clinical sessions planned by David Sarraf. Look up the complete program at http://www.apmeetings.com/singolo_evento_sem.php?id=3&lang=en

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Lawrence A. Yannuzzi

    9. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Explore OSA | OSA Publishing Gynecology
      Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our method on centimeter-scale mosaic OCT volumes of uterine tissue blocks from pregnant and non-pregnant specimens revealing a complex, patient-specific network of fibrous collagen and myocyte bundles.

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      Mentions: Columbia University Christine P. Hendon

    10. Open Source Optical Coherence Tomography Software

      Explore Journal of Open Source Software
      Open Source Optical Coherence Tomography Software

      Optical coherence tomography (OCT) is a non-invasive imaging technique that is often described as the optical equivalent to ultrasound imaging. The basic building block of OCT acquisitions is an optical interference pattern that can be processed into a depth profile, which is also called A-scan. Several adjacent A-scans can be merged into a cross-sectional image. Most research that incorporates OCT requires a software solution for processing of the acquired raw data. Here we present an open source software package for OCT processing with an easy to use graphical user interface. The implemented OCT processing pipeline enables A-scan processing rates in ...

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      Mentions: University of Hannover

    11. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

      Explore European Respiratory Journal Pulmonology
      Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

      Introduction: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma that reduces airway smooth muscle (ASM) by radiofrequent energy. No diagnostic method is currently available to assess ASM, other than invasive, focal airway biopsies. Bronchoscopic standard optical coherence tomography (OCT) generates high resolution images of the airways. Polarization sensitive OCT (PS-OCT) provides tissue-specific contrast that might enable ASM detection and quantification. Aim: Use novel PS-OCT to detect ASM and determine changes in ASM before and after BT in severe asthma. Methods: Bronchoscopic PS-OCT was performed from distal to proximal airways in a severe asthma patient before and after BT ...

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    12. Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio

      Explore Optical Coherence Tomography News Other Business News
      Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio

      Thorlabs announced today that it has expanded its Swept Source OCT (SS-OCT) offering with the release of Atria™ systems centered at 1060 nm. These new systems, which integrate Thorlabs’ patented MEMS-VCSEL swept-wavelength technology, are available in 60 kHz (ATR206C1) and 200 kHz (ATR220C1) variants, including a version with an ultra-long imaging depth of 20 mm. The 1060 nm options offer the same low roll-off and high sensitivity performance found in the already well-established VEGA™ swept source OCT series. Also like the Vega series, the Atria’s MEMS-VCSEL swept source and imaging module are packaged into a single housing, with the ...

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      Mentions: Thorlabs

    13. In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      Explore Home - IOS Press Otolaryngology
      In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      Exposure to noise trauma, such as that from improvised explosive devices, can lead to sensorineural hearing loss and a reduced quality of life. In order to elucidate the mechanisms underlying noise-induced hearing loss, we have adapted optical coherence tomography (OCT) for real-time cochlear visua lization in live mice after blast exposure. We demonstrated that endolymphatic hydrops develops following blast injury, and that this phenomenon may be associated with glutamate excitotoxicity and cochlear synaptopathy. Additionally, osmotic stabilization of endolymphatic hydrops partially rescues cochlear synapses after blast trauma. OCT is thus a valuable research tool for investigating the mechanisms underlying acoustic trauma ...

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      Mentions: UCLA Brian E. Applegate John S. Oghalai

    14. Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall

      Explore OSA | OSA Publishing
      Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall

      Here we provide a counter-example to the conventional wisdom in biomedical optics that longer wavelengths aid deeper imaging in tissue. Specifically, we investigate visible light optical coherence tomography of Bruch’s membrane (BM) in the non-pathologic eyes of humans and two mouse strains. Surprisingly, we find that shorter visible wavelengths improve the visualization of BM in pigmented eyes, where it is located behind a highly scattering layer of melanosomes in the retinal pigment epithelium (RPE). Monte Carlo simulations of radiative transport suggest that, while absorption and scattering are higher at shorter wavelengths, detected multiply scattered light from the RPE is ...

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      Mentions: Vivek J. Srinivasan UC Davis Robert J. Zawadzki

    15. Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry

      Explore IEEE Xplore NDE/NDT
      Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry

      Large-scale product inspection is an important aspect in thin film industry to identify defects with a high precision. Although vision line scan camera (VLSC)-based inspection has been frequently implemented, it is limited to surface inspections. Therefore, to overcome the conventional drawbacks, there is a need to extend inspection capabilities to internal structures. Considering that VLSC systems have access to rich information, such as color and texture, high-resolution real-time multimodal optical synchronization between VLSC and dual spectral domain optical coherence tomography (SD-OCT) systems was developed with a laboratory customized in-built automated defect-tracking algorithm for optical thin films (OTFs). Distinguishable differences ...

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      Mentions: University of Ulsan Jeehyun Kim Kyungpook National University

    16. Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions

      Explore Dove Medical Press Ophthalmology
      Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions

      Purpose: To present a systematic review of the current body of literature surrounding spaceflight associated neuro-ocular syndrome (SANS) and highlight priorities for future research. Methods: Three major biomedical databases were searched with the following terms: ((neuro ocular) OR ((brain) AND (eye))) AND ((spaceflight) OR (astronaut) OR (microgravity)) AND (ENGLISH[Language]). Once duplicates were removed, 283 papers were left. Articles were excluded if they were not written in English or conference abstracts only. We avoided including review papers which did not provide any new information; however, two reviews on the pathophysiology of SANS were included for completeness. No limitations on date ...

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      Mentions: University of Colorado

    17. Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      Explore Home - Springer Microscopy
      Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      A bacterium in bacterial colony is a basal component of bacterial studies and is therefore of considerable importance. The morphological characteristics of a single colony have been widely used as the standard to identify diverse bacterial species. However, the conventional methods for obtaining morphological information, such as microscopic techniques, cannot provide tomographic views. This study utilizes spectral-domain optical coherence tomography (SD-OCT) to observe both external and internal structures for single colonies. OCT imaging provided a clear top (projection) and lateral (cross-sectional) images, which can identify distinct features in the fifteen different bacterial species examined. Through the acquired OCT images, the ...

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      Mentions: Jeehyun Kim Kyungpook National University Ruchire Eranga Wijesinghe

    18. Research Center Pharmaceutical Engineering Awarded Two FDA Contracts for Next-Generation Pharma Technology

      Explore Optical Coherence Tomography News NDE/NDT
      Research Center Pharmaceutical Engineering Awarded Two FDA Contracts for Next-Generation Pharma Technology

      The Research Center Pharmaceutical Engineering GmbH (RCPE), a global leader in pharmaceutical engineering sciences, has been awarded FDA funding for two projects commencing in the 4th quarter of 2020. The projects will focus on utilising advanced technologies to improve production processes within Pharma. With an average of only 5 – 10 projects awarded to EU companies by the FDA each year, this development represents a landmark achievement for RCPE and reflects the potential impact of these projects within the global pharma industry. In partnership with major global pharma companies, including MSD and Pfizer, RCPE will use the FDA funding to investigate ...

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      Mentions: University of Graz FDA Thomas Klein

    19. Early vascular modifications after endoscopic endonasal pituitary surgery: The role of OCT-angiography

      Explore Journals | PLOS
      Early vascular modifications after endoscopic endonasal pituitary surgery: The role of OCT-angiography

      Purpose The aim of the present study is to analyze the changes in retinal vessel density (VD), using Optical Coherence Tomography Angiography (OCT-A), in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing optic chiasm. Methods We evaluated the VD in Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), Radial Peripapillary Capillary (RPC) and the Foveal Avascular Zone (FAZ) area in a series of fourteen patients (7 males, 7 females, mean age 56 ± 13 years), as compared to healthy controls. We also detected the structural Spectral Domain (SD)-OCT parameters: Ganglion Cell Complex (GCC ...

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    20. Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo

      Explore MDPI Open Access Journals Platform Dentistry
      Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo

      The aim of this study was to assess the utility of 3D imaging of optical coherence tomography (OCT) for the diagnosis of occlusal tooth wear ex vivo. Sixty-three extracted human molars with or without visible tooth wear were collected to take digital intraoral radiography and 3D OCT images. The degree of tooth wear was evaluated by 12 examiners and scored using 4-rank scale: 1—slight enamel wear; 2—distinct enamel wear; 3—tooth wear with slight dentin exposure; 4—tooth wear with distinct involvement of dentin. The degree of tooth wear was validated by the histological view of confocal laser ...

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      Mentions: University of Washington Yasunori Sumi Tokyo Medical & Dental University
    21. See all articles

  2. Recent Articles From Around The Web

    1. DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      Explore Home - Springer Ophthalmology
      DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      OCTA imaging is an emerging modality for the discovery of retinal biomarkers in systemic disease. Several studies have already shown the potential of deep learning algorithms in the medical domain. However, they generally require large amount of manually graded images which may not always be available. In our study, we aim to investigate whether transfer learning can help in identifying patient status from a relatively small dataset. Additionally, we explore if data augmentation may help in improving our classification accuracy. Finally, for the first time, we propose a validation of our model on OCTA images acquired with a different device ...

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    2. Full-field optical coherence tomography—An educational setup for an undergraduate lab

      Explore Scitation
      Full-field optical coherence tomography—An educational setup for an undergraduate lab

      Optical coherence tomography, or in short OCT, is a measurement technique established in the early 1990s for the non-invasive imaging of interfaces in the bulk of biological tissues or other samples. A full-field OCT setup is built from a microscope combined with a Michelson interferometer, where the mirror in one arm is replaced by the sample. Using white light, which is temporally partially coherent, interference fringes disclose the presence of an interface whenever the lengths of both interferometer arms are nearly equal. Scanning one arm allows for a volumetric reconstruction of all interfaces inside the sample. While the importance of ...

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    3. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Explore OSA | OSA Publishing
      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      We report on the investigation of spectral leakage’s impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches the theoretical resolution limit.

      Read Full Article
      Mentions: University of Alabama Medical University of Vienna Singapore Eye Research Institute

    4. Axial Super-Resolution Study for Optical Coherence Tomography Images via Deep Learning

      Explore IEEE Xplore
      Axial Super-Resolution Study for Optical Coherence Tomography Images via Deep Learning

      Optical coherence tomography (OCT) is a noninvasive, high resolution, and real-time imaging technology that has been used in ophthalmology and other medical fields. Limited by the point spread function of OCT system, it is difficult to optimize its spatial resolution only based on hardware. Digital image processing methods, especially deep learning, provide great potential in super-resolving images. In this paper, the matched axial low resolution (LR) and high resolution OCT image pairs from actual OCT imaging are collected to generate the dataset by our home-made spectral domain OCT (SD-OCT) system. Several methods are selected to super-resolve LR OCT images. It ...

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      Mentions: Yanmei Liang Tianjin University

    5. Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

      Explore ScienceDirect Ophthalmology
      Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

      Abstract Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated the structural neuro-retinal abnormalities, especially the thickness in the ganglion cell complex (GCC), in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC thickness in MELAS patients was significantly thinner than that in normal controls even when they had no history of transient homonymous hemianopia. There was a negative correlation between GCC thickness and disease duration. In conclusion, OCT may be an effective tool to monitor and predict disease progression in MELAS patients.

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    6. Evaluation of Accuracy and Agreement of Optical Coherence Tomography Angiography Interpretation of Common Retinal Findings and Diagnoses

      Explore Karger Publishers Ophthalmology
      Evaluation of Accuracy and Agreement of Optical Coherence Tomography Angiography Interpretation of Common Retinal Findings and Diagnoses

      Abstract Purpose: To evaluate the accuracy and agreement of OCTA interpretation in cases of common retinal findings and diagnoses, and evaluate the effect of the OCT B-scans on OCTA interpretations. Methods: A case-series study, consisting of a questionnaire with 8 cases demonstrating common retinal conditions of normal, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Each case included OCTA images, and 58 participants were asked to identify retinal findings and provide a diagnosis. Following OCTA interpretation, the corresponding OCT B-scans were revealed and participants were asked again to identify retinal findings and provide a diagnosis. Rates of accuracy and agreement ...

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    7. Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients

      Explore ies.ijo.cn Ophthalmology
      Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients

      AIM To observe the findings of spectral domain optical coherence tomography (SD-OCT) scan in cytomegalovirus retinitis (CMVR). METHODS Forty-six eyes of 33 patients with acquired immunodeficiency syndrome and CMVR were enrolled in the study. Complete ophthalmologic examinations, color fundus photography, SD-OCT and fundus autofluorescence (FAF) were performed for all patients at the first visit and each follow-up visit. Retinal necrosis in CMVR was analyzed on SD-OCT and classified into two types, the typical type and the atypical type. RESULTS Forty-one eyes of active CMVR and 4 eyes of recurrent CMVR were classified into typical type, and 4 eyes with graying ...

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      Mentions: Zhejiang University

    8. Evaluating anterior segment structure using anterior segment optical coherence tomography in malignant glaucoma after Ahmed valve implantation

      Explore LWW Online Ophthalmology
      Evaluating anterior segment structure using anterior segment optical coherence tomography in malignant glaucoma after Ahmed valve implantation

      Rationale: Malignant glaucoma is a rare condition that can be associated with surgery for glaucoma. In the present case report, we describe a case of malignant glaucoma occurring a week after Ahmed valve implantation. The change in anterior segment structure was identified using anterior segment optical coherence tomography (AS-OCT). Patient concerns: The 86-year-old woman with pseudoexfoliation glaucoma underwent Ahmed valve implantation. A week later, the intraocular pressure (IOP) increased to 74 mm Hg. Diagnosis: The anterior chamber was totally collapsed with conjunctival injection and edematous cornea. Finally, the patient was diagnosed with malignant glaucoma. The structure of anterior chamber was ...

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    9. Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Explore Taylor & Francis Online Ophthalmology
      Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Purpose To evaluate the agreement between a new UBM and a SS-OCT. Methods The scans of the right eye of each volunteer were obtained using the 2 devices. Data were fitted and recorded including: central corneal thickness (CCT), aqueous depth (AQD) (the distance from endothelium to lens), angle-to-angle distance (ATA), lens thickness (LT), diameter of the lens in the horizontal direction (LDia angle : distance between the sharp angles on both sides of the lens, LDia arc : distance between the vertex of the circular arcs on both sides of the lens), anterior and posterior corneal radius (Rf and Rb). Results 25 ...

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    10. PhD position in the Applied Optics Group, University of Kent, Canterbury UK

      Explore Optical Coherence Tomography News NDE/NDT , Jobs & Studentships
      PhD position in the Applied Optics Group, University of Kent, Canterbury UK

      Project Summary Plant cuticle and underlying epidermis forms the outermost layer protecting plants from desiccation and from abiotic and biotic stresses. The cuticle comprises mainly of polyester cutin and epicuticular waxes that help to prevent moisture loss and maintenance of cell turgor. In fruits changes in surface properties play an important role in increasing consumer appeal during maturation through development of ‘blooms’ and colour changes. Importantly, the cuticle and epidermis form a mechanical barrier acting as the first-line in defence against the ingress from plant pathogens. The PhD Studentship will aim to develop optical coherence tomography (a non-invasive high-resolution microscopy ...

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      Mentions: Adrian G. Podoleanu University of Kent

    11. How can optical coherence tomography be used to optimize percutaneous coronary intervention?

      Explore Home Cardiology
      How can optical coherence tomography be used to optimize percutaneous coronary intervention?

      Optical coherence tomography (OCT) imaging provides high resolution assessment of coronary parietal and endoluminal abnormalities. Clinical evidence and intuitive utilization make this tool relevant for use in daily practice in the catheterization laboratory. In the present review, we summarize the benefits of OCT for the optimization of percutaneous coronary intervention (PCI) in daily practice. First, we focus on the characterization of lesion type with a view to anticipating challenges during PCI. Then, we describe the utility of OCT to identify culprit lesions and ambiguous angiographic findings. Finally, we outline targets for optimization after PCI and the mechanisms underlying stent failure.

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    12. When to use intravascular ultrasound or optical coherence tomography during percutaneous coronary intervention?

      Explore Home Cardiology
      When to use intravascular ultrasound or optical coherence tomography during percutaneous coronary intervention?

      Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are intravascular imaging technologies widely used in the cardiac catheterization laboratory. The impact of these modalities for optimizing the acute and longer-term clinical impact following percutaneous coronary intervention (PCI) is supported by a wealth of clinical evidence. Intravascular imaging provides unique information for enhanced lesion preparation, optimal stent sizing, recognizing post PCI complications, and the etiology of stent failure. This review compares and contrasts the key aspects of these imaging modalities during PCI.

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      Mentions: Cleveland Clinic

    13. Optical coherence tomography: fundamentals and clinical utility

      Explore Home Cardiology
      Optical coherence tomography: fundamentals and clinical utility

      Although coronary angiography is the standard method employed to assess the severity of coronary artery disease and to guide treatment strategies, it provides only 2D image of the intravascular lesions. In contrast, intravascular imaging modalities such as optical coherence tomography (OCT) produce cross-sectional images of the coronary arteries at a far greater spatial resolution, capable of accurately determining vessel size as well as plaque morphology, eliminating many of the disadvantages inherent to angiography. This review will discuss the role of OCT in the catherization laboratory for the assessment and management of coronary disease.

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      Mentions: University of Queensland

    14. The assessment of intermediate coronary lesions using intracoronary imaging

      Explore Home Cardiology
      The assessment of intermediate coronary lesions using intracoronary imaging

      Intermediate coronary artery stenosis, defined as visual angiographic stenosis severity of between 30–70%, is present in up to one quarter of patients undergoing coronary angiography. Patients with this particular lesion subset represent a distinct clinical challenge, with operators often uncertain on the need for revascularization. Although international guidelines appropriately recommend physiological pressure-based assessment of these lesions utilizing either fractional flow reserve (FFR) or quantitative flow ratio (QFR), there are specific clinical scenarios and lesion subsets where the use of such indices may not be reliable. Intravascular imaging, mainly utilizing intravascular ultrasound (IVUS) and optical coherence tomography (OCT) represents an ...

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    15. In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations

      Explore Home Cardiology
      In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations

      In vivo imaging of plaque instability has been considered to have a great potential to predict future coronary events and evaluate the stabilization effect of novel anti-atherosclerotic medical therapies. Currently, there are several intravascular imaging modalities which enable to visualize plaque components associated with its vulnerability. These include virtual histology intravascular ultrasound (VH-IVUS), integrated backscatter IVUS (IB-IVUS), optical coherence tomography (OCT), near-infrared spectroscopy and coronary angioscopy. Recent studies have shown that these tools are applicable for risk stratification of cardiovascular events as well as drug efficacy assessment. However, several limitation exists in each modality. The current review paper will outline ...

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      16. See all articles
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    PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston Quantification of plant morphology and leaf thickness with optical coherence tomography Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award Optical coherence tomography in the 2020s—outside the eye clinic 8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020” Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT Open Source Optical Coherence Tomography Software Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio

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    1. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    2. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    3. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    4. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    5. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    6. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    7. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    8. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    9. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    10. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen