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  3. Organizations in the News

    (3 articles) University of Iowa

    (3 articles) UC Irvine

    (2 articles) University of Kent

    (2 articles) GE Healthcare

    (1 articles) University of Otago

    (1 articles) State University of New York at Buffalo

    (1 articles) Kyoto University Graduate School of Medicine

    (1 articles) Victor Babes University of Medicine and Pharmacy

    (1 articles) Thoraxcenter at Erasmus University Medical Center

    (1 articles) National Research Council Canada

  4. People in the News

    (3 articles) Kyungmoo Lee

    (3 articles) Michael D. Abramoff

    (2 articles) Young H. Kwon

    (2 articles) Adrian Bradu

    (2 articles) Cosmin Sinescu

    (2 articles) Adrian G. Podoleanu

    (2 articles) Zhongping Chen

    (1 articles) Constance R. Chu

    (1 articles) Dirk-Uwe G. Bartsch

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  5. OCT Companies in the News

    (4 articles) Volcano

    (3 articles) Carl Zeiss Meditec

    (2 articles) Siemens

    (1 articles) Heidelberg Engineering

    (1 articles) Imalux

  6. OCT Products in the News

    (2 articles) Zeiss Visante OCT

    (1 articles) Heidelberg Spectralis

    (1 articles) Imalux Niris

    (1 articles) Zeiss Stratus OCT

  7. Picture Gallery

  8. Popular Articles

  9. Recent Quotes

    1. “ The positive 30-day results reaffirm my belief that a device that bioresorbs, or disappears, into the body after restoring blood flow is the next logical step in the treatment of cardiovascular disease. ”
      By Patrick W. Serruys
    2. “ Our technology innovation, market development, clinical and product initiatives have fueled our growth during 2009 and leave us well positioned for a strong 2010 marked by excellent revenue growth and GAAP profitability. ”
      By Scott Huennekens
    3. “ If we can catch it early, the incipient tumour is small and can be easily excised, for a complete cure in most cases. but if it has been allowed to develop, the treatment is expensive, invasive, often disfiguring surgery, with a poor prognosis. We really need a fast, non-invasive way to scan the many lumps that develop in the mouths of users of tobacco, alcohol and betel nut, to see when one is developing a cancer – now, it really looks like OCT imaging is the answer ”
      By Colin Hopper
    4. “ This is a remarkable milestone for Michelson Diagnostics, as it shows, through a statistically significant sample, that multi-beam OCT technology has the potential to play an important role in the early diagnosis of cancer. ”
      By Jon Holmes
    5. “ These ex-vivo results are very encouraging and we expect the in-vivo results to be even better, due to better contrast on perfused tissue. ”
      By Colin Hopper
    6. “ Stratus OCT RNFL parameters were able to discriminate eyes with progressing disease by visual fields or optic disc photographs with eyes that remained stable according to these methods, and performed significantly better than [optic nerve head] and macular thickness parameters in detecting change over time. ”
      By Felipe A. Medeiros
    7. “ At a comparable level of specificity, Spectralis OCT RNFL measurement attained a higher sensitivity than HRT optic disc measurement. ”
      By Chris K. S. Leung
    8. “ I am becoming a big fan of spectral-domain OCT, especially Spectralis [Heidelberg Engineering, Vista, Calif.]...To this point with time-domain OCT, I have not been convinced that you can use this technology to follow patients over time. Now, with the faster image acquisition and better axial resolution we see with SD OCT, there is better quantitative peripapillary retinal nerve fiber layer measurement for glaucoma management. The improved accuracy of the OCT segmentation allows for better long-term evaluation of patients. ”
      By Leon W. Herndon
    9. “ We saw [the Volcano deal] as a way in a tough financial market to raise much needed funds. ”
      By Steven Healy
    10. “ Volcano is excited to fortify its commitment to be the leading and most-trusted partner for physicians when addressing patients with complex disease states that require thrombus aspiration. ”
      By Scott Huennekens

  1. Feature Of The Week

    Photoacoustic Ophthalmoscopy (PAOM) is based on Laser-scanning Optical Resolution Photoacoustic Microscopy (LS-OR-PAM), which is a branch of photoacoustic microscopy (PAM). LS-OR-PAM was first developed with the collaboration of Dr. Hao Zhang's lab at University of Wisconsin-Milwaukee and Dr. Shuliang Jiao lab at University of Southern California.

    PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The integrated system can provide optical absorption and scattering contrasts in biological tissues. The multi-modal images are intrinsically registered. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

    For more information see recent Article. To share or email this article click Here. Courtesy Dr. Shuliang Jiao and Dr. Hao Zhang. Click "Full Screen" for better viewing.

  2. Featured Articles

    1. Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography

      Explore Article JACC (13 hours, 35 min ago) Cardiology

      Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography A 50-year-old man with a recent embolic stroke was referred by a neurologist for abnormal electrocardiography results consistent with large anterior myocardial infarction. Echocardiogram results showed akinesis of the anteroapical left ventricular wall without obvious mural thrombus and an ejection fraction of 45%. There was no evidence of an intracardiac shunt. Coronary angiography revealed irregular linear filling defects in the mid left anterior descending artery (A) (line 1 and 2 indicate the length of optical coherence tomography pullback). Optical coherence tomography showed multiple channels surrounding a larger central lumen (B, arrowheads). The channels were seen to communicate both with each ... (Read Full Article)

      Comment on Article Mentions:   Massachusetts General Hospital   Ik-Kyung Jang   Harvard University

    2. Optical Coherence Tomography of the Larynx Using the Niris System

      Explore Article BCDecker (19 hours, 46 min ago) Otolaryngology

      Optical Coherence Tomography of the Larynx Using the Niris System OBJECTIVES:To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.METHODS:Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 μm and a depth scanning range of 2.2 mm, obtaining images of 200 × 200 pixels ... (Read Full Article)

      Comment on Article Mentions:   Imalux   Zhongping Chen   Jeong H. Kim

    3. In-stent restenosis associated with stent malapposition: Seven year optical coherence tomography findings

      Explore Article International Journal of Cardiology (Mar 14 2010) Cardiology

      In-stent restenosis associated with stent malapposition: Seven year optical coherence tomography findings Abstract: Stent thrombosis and in-stent restenosis remain significant issues in post-coronary angioplasty care despite advances in anti-platelet therapy and stent technology. Angiographic predictors of stent failure have been proposed, but its precise mechanism has been difficult to elucidate on conventional coronary angiography and intravascular ultrasound due to the low resolution of either approach. Optical coherence tomography (OCT) as a high-resolution intracoronary imaging modality has enabled more detailed insight into the interaction between implanted stent and underlying endothelium, the evolution of unstable plaque, and the pathogenesis of late lumen loss, affirming its place as an essential tool in the modern-day cardiac ... (Read Full Article)

      Comment on Article Mentions:   Peter Barlis   University of Melbourne

    4. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats

      Explore Article ScienceDirect (Mar 14 2010) Neurology , Ophthalmology

      Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats Purpose To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants. Methods Donor retinal sheets were isolated from E19 fetuses of transgenic rats expressing human alkaline phosphatase (hPAP), and transplanted to the subretinal space of 19–56 days old S334ter-3 rat recipients with fast retinal degeneration (average age at surgery 32 days). A total of 143 rats were imaged 1 day to 2.8 months after surgery, using a Fourier-domain optical coherence tomography (FDOCT) system, with an axial resolution of 3.5 μm. The CCD A-line integration time was set at 200 μs ... (Read Full Article)

      Comment on Article Mentions:   Zhongping Chen   UC Irvine

    5. Lihong Wang and Hsin-I Wu receive Goodman Book Writing Award from SPIE and OSA

      Explore Article Home: SPIE.org (Mar 11 2010)

      Lihong Wang and Hsin-I Wu receive Goodman Book Writing Award from SPIE and OSA BELLINGHAM, Washington, and WASHINGTON, D.C., USA -- Lihong V. Wang and Hsin-I Wu are recipients of the 2010 Joseph W. Goodman Book Writing Award for their book Biomedical Optics: Principles and Imaging, the Optical Society (OSA) and SPIE have announced. The Goodman Award, a biennial award funded by a personal gift from Joseph W. and Hon Mai Goodman, recognizes a recent and outstanding book in the field of optics and photonics that has contributed significantly to research, teaching, or the optics and photonics industry. This year, the Goodman Book Writing Award will be bestowed upon Wang and Wu at the ... (Read Full Article)

      Comment on Article Mentions:   Lihong V. Wang   Texas A&M University   Hsin-i Wu

    6. Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy

      Explore Article SpringerLink Home (Mar 11 2010) Oncology

      Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy Gold nanorods (GNRs) are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics. GNRs can support nonlinear optical microscopies based on two-photon-excited luminescence and can enhance the contrast of biomedical imaging modalities such as optical coherence tomography and photoacoustic tomography. GNRs are also efficient at mediating the conversion of NIR light energy into heat and can generate localized photothermal effects. However, future clinical applications will require the rigorous removal of CTAB, a micellar surfactant used in GNR synthesis, and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific ... (Read Full Article)

      Comment on Article Mentions:   Purdue University   Alexander Wei

    7. Potential of optical coherence tomography for early diagnosis of oral malignancies

      Explore Article Expert Reviews (Mar 11 2010) Oncology

      With nearly 1,500,000 new patients diagnosed every year in the USA, cancer poses a considerable challenge to healthcare today. Oral cancer is responsible for a sizeable portion of deaths due to cancer, primarily because it is diagnosed at a late stage when the prognosis is poor. Current methods for diagnosing oral cancer need to be augmented by better early detection, monitoring and screening modalities. A new approach is needed that provides real-time, accurate, noninvasive diagnosis. The results of early clinical trials using in vivo optical coherence tomography for the diagnosis of oral dysplasia and malignancy are encouraging. (Read Full Article)

      Comment on Article Mentions:   UC Irvine   Petra Wilder-Smith

    8. Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography

      Explore Article SpringerLink Home (Mar 11 2010) Dermatology , Doppler

      Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in blood vessel phantom and in vivo subcutaneous ... (Read Full Article)

      Comment on Article Mentions:   Medical University of Vienna   University of Otago   Igor V. Meglinski

    9. A new device for assessing changes in skin viscoelasticity using indentation and optical measurement

      Explore Article www3.interscience.wiley.com (Mar 10 2010) Dermatology

      A new device for assessing changes in skin viscoelasticity using indentation and optical measurement Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ... (Read Full Article)

      Comment on Article Mentions:   Imperial College London   University of Limerick

    10. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

      Explore Article www3.interscience.wiley.com (Mar 10 2010)

      Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI T2 values and arthroscopy. Methods: Patients undergoing arthroscopy for degenerative meniscal tears were recruited under IRB approved protocols. 30 consecutive subjects completing preoperative 3.0T MRI, arthroscopy, and intraoperative OCT comprised ... (Read Full Article)

      Comment on Article Mentions:   University of Pittsburgh   Constance R. Chu

    11. Motion artifact suppression in full-field optical coherence tomography

      Explore Article opticsinfobase.org (Mar 8 2010)

      Motion artifact suppression in full-field optical coherence tomography Significant motion artifacts limit the performance of conventional full-field optical coherence tomography (FF-OCT) for in-vivo imaging. We present a theoretical and experimental study of those limitations. A new FF-OCT system suppressing most of artifacts due to sample motions is demonstrated using instantaneous phase shifting with nonpolarizing optics and pulsed illumination. The experimental setup is based on a Linnik-type interferometer illuminated by the superluminescence emission from a Ti:Al2O3 waveguide crystal. En face tomographic images are calculated as a combination of two phase-opposed interferometric images acquired simultaneously by two CCD cameras placed at both outputs of the interferometer, with a spatial resolution ... (Read Full Article)

      Comment on Article Mentions:   Arnaud Dubois   Institut d'Optique

    12. Morphologic characteristics of late stent malapposition after drug-eluting stents implantation by optical coherence tomography follow-up

      Explore Article Chinese Medical Journal (Mar 8 2010) Cardiology

      Morphologic characteristics of late stent malapposition after drug-eluting stents implantation by optical coherence tomography follow-up Background Late stent malapposition was frequently observed after DES implantation, which has been associated with the occurrence of late stent thrombosis due to poor neointimal coverage. This study was designed to evaluate the frequency of late stent malapposition at least 1 year after different DESs implantation by optical coherence tomography (OCT).Methods Angiographic and OCT examinations were given to 68 patients who had received total 126 various DESs implantation for at least 1 year to detect late stent malapposition. Malapposed strut distance (MSD), malapposed strut area (MSA), reference lumen area (RLA) and reference stent area (RSA) were checked with off-line OCT ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   Lightlab ImageWire

    13. Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

      Explore Article www3.interscience.wiley.com (Mar 7 2010) Oncology

      Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP/NB, and 60% G/SP/BC ... (Read Full Article)

      Comment on Article

    14. Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand

      Explore Article Circulation Research (Mar 7 2010) Cardiology , Developmental Biology

      Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand Rationale: Drosophila has been recognized as a model to study human cardiac diseases. Objective: Despite these findings, and the wealth of tools that are available to the fly community, forward genetic screens for adult heart phenotypes have been rarely performed because of the difficulty in accurately measuring cardiac function in adult Drosophila. Methods and Results: Using optical coherence tomography to obtain real-time analysis of cardiac function in awake Drosophila, we performed a genomic deficiency screen in adult flies. Based on multiple complementary approaches, we identified CG31665 as a novel gene causing dilated cardiomyopathy. CG31665, which we name weary (wry), has ... (Read Full Article)

      Comment on Article Mentions:   Duke University   Bioptigen

    15. Australia & New Zealand Optical Coherence Tomography Workshop May 7th, 2010

      Explore Article Optical Coherence Tomography News (Mar 5 2010) Cardiology

      Australia & New Zealand Optical Coherence Tomography Workshop May 7th, 2010 “Welcome to the Inaugural Australia & New Zealand Optical Coherence Tomography Workshop. We have set out a program with an internationally recognized faculty to review the use of OCT and discuss its exciting role in Interventional Cardiology. Thank you for joining us”. Peter Barlis & Rob Whitbourn. Enquiries to info@anzoct.org or go to www.anzoct.org. false false false EN-US X-NONE X-NONE (Read Full Article)

      Comment on Article Mentions:   Peter Barlis   University of Melbourne   LightLab Imaging

    16. Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea

      Explore Article opticsinfobase.org (Mar 4 2010) Broadband Sources

      Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea A Ce3+:YAG double-clad crystal fiber (DCF) visible emission was used as the light source for optical coherence tomography (OCT). The visible emission was produced from a 10 μm core DCF pumped by a diode laser. The broadband emission and short central wavelength of this light source enabled the realization of 1.5 μm axial resolution in air. The relatively clean spectrum reduced the side lobe of its point-spread function, and therefore facilitated the generation of a high-quality image with less crosstalk between adjacent image pixels. As a demonstration, an Aplocheilus lineatus goldfish was experimented on to map out the stroma of ... (Read Full Article)

      Comment on Article Mentions:   National Taiwan University

    17. Clinical studies of frequency domain optical coherence tomography in the coronary arteries: the first 200 patients

      Explore Article SPIE Digital Library (Mar 4 2010) Cardiology

      Clinical studies of frequency domain optical coherence tomography in the coronary arteries: the first 200 patients We report clinical study results of three-dimensional (3D) in vivo imaging of human coronary arteries using frequency domain optical coherence tomography (FD-OCT). At the time of this report, over 2000 patients in over 10 countries have been imaged using FD-OCT systems and disposable fiberoptic catheters developed by LightLab Imaging Inc. The first commercial versions of the systems were introduced in Europe in May 2009. The system operates at 50,000 axial lines/s, performing a 50 mm spiral pullback in 2.5 seconds with a rotational frame rate of 100 Hz. The commercial system employs a proprietary micro-cavity swept laser, allowing imaging of ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   Desmond C. Adler   Joseph M. Schmitt

    18. In Vivo Supervised Analysis of Stent Reendothelialization From Optical Coherence Tomography

      Explore Article IEEE Xplore (Mar 4 2010)

      In Vivo Supervised Analysis of Stent Reendothelialization From Optical Coherence Tomography The aim of this study is to interactively assess reendothelialization of stents at an accuracy of down to a few micrometer by analyzing endovascular optical coherence tomography (OCT) sequences. Vessel wall and stent struts are automatically detected by using morphological, gradient, and symmetry operators coupled with active contour models; alerts are issued to ask for user supervision over some extreme irregular geometries caused by thrombotic lesions or dissections. A complete distance map is then computed from sparse distances measured between wall and struts. Missing values are interpolated by thin-plate spline (TPS) functions. Accuracy and robustness are increased by taking into ... (Read Full Article)

      Comment on Article Mentions:   LightLab Imaging   University of Montreal   Lightlab ImageWire

    19. 1st Massachusetts General Hospital OCT Registry Symposium Scheduled for March 13, 2010

      Explore Article Optical Coherence Tomography News (Mar 3 2010) Cardiology

      1st Massachusetts General Hospital OCT Registry Symposium Scheduled for March 13, 2010 The utilization of OCT has grown tremendously since the launch of the world’s first frequency domain OCT system (FD-OCT) from LightLab Imaging, Inc. in late 2009. Over 9,000 cases were performed last year, slightly less than the cumulative cases performed in the three years prior with the older Time Domain OCT which was much slower and harder to use. “OCT has come a long way". States Dr. Ik-Kyung Jang. "I have used the new system and it is really fast and easy to use. Because of its data acquisition speed no occlusion is required and the image quality is improved ... (Read Full Article)

      Comment on Article Mentions:   Massachusetts General Hospital   Ik-Kyung Jang   LightLab Imaging

    20. Visualizing ocular perfusion with optical microangiography

      Explore Article Home: SPIE.org (Mar 3 2010) Ophthalmology

      Visualizing ocular perfusion with optical microangiography Better assessment of ocular blood circulation may provide important diagnostic and treatment information for eye pathologies such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Currently, the preferred methods to visualize ocular blood perfusion in the clinic are fluorescein angiography (FA) and indocyanine green angiography (ICGA). Both provide detailed maps of the retina and choroid that are useful in decision making. However, injecting dyes with possible side effects is undesirable. Moreover, those methods cannot provide depth-resolved visualization of vasculatures. Therefore, a noninvasive technique that can show retinal and choroidal blood perfusion in depth would be a significant advance. We have ... (Read Full Article)

      Comment on Article Mentions:   Ruikang K. Wang   Lin An   Oregon Health & Science University

    21. See all featured articles >>

  3. Recent Articles From Around The Web

    1. Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology

      Explore Article PR Newswire (23 hours, 6 min ago) Cardiology , Other Business News

      e ABSORB trial is a prospective, non-randomized (open label), two-phase study that enrolled 131 patients from Australia, Belgium, Denmark, France, the Netherlands, New Zealand, Poland and Switzerland. Key endpoints of the study include assessments of safety – MACE and treated site thrombosis rates – at 30 days; six, nine, 12, 18 and 24 months; with additional annual clinical follow-up for up to five years, as well as an assessment of the acute performance of the bioresorbable vascular scaffold, including successful deployment of the system. Other key endpoints of the study include imaging assessments by angiography, intravascular ultrasound (IVUS), optical coherence ... (Read Full Article)

      Comment on Article Mentions:   Patrick W. Serruys   Thoraxcenter at Erasmus University Medical Center

    2. Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography

      Explore Article Optical Coherence Tomography News (Mar 14 2010) Ophthalmology

      Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography Feature Of The Week 3/14/10: Photoacoustic Ophthalmoscopy (PAOM) is based on Laser-scanning Optical Resolution Photoacoustic Microscopy (LS-OR-PAM), which is a branch of photoacoustic microscopy (PAM). LS-OR-PAM was first developed with the collaboration of Dr. Hao Zhang's lab at University of Wisconsin-Milwaukee and Dr. Shuliang Jiao lab at University of Southern California. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high ... (Read Full Article)

      Comment on Article Mentions:   Shuliang Jiao   University of Wisconsin   Keck School of Medicine

    3. A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa

      Explore Article iovs.org (Mar 14 2010) Ophthalmology

      Purpose: To explore the relationship between visual field sensitivity and photoreceptor layer thickness in patients with retinitis pigmentosa (RP). Methods: Static automated perimetry with Humphrey Field Analyzer (central 30-2 threshold program with spot size III) and frequency domain optical coherence tomography (fd-OCT) scans with Spectralis HRA+OCT were obtained from 10 age-matched normal controls and 20 patients with RP retaining good central vision (better than 20/32). The OS+ thickness [the distance between retinal pigment epithelium (RPE)/Bruch's membrane (BM) to the photoreceptor inner-outer segment junction], outer nuclear layer (ONL) and total retinal thickness were measured at locations corresponding to visual field test ... (Read Full Article)

      Comment on Article Mentions:   Heidelberg Spectralis   Columbia University   Heidelberg Engineering

    4. Fundus Autofluorescence, Optical Coherence Tomography, and Electroretinogram Findings in Choroidal Sclerosis

      Explore Article LWW Online (Mar 14 2010) Ophthalmology

      Purpose: The purpose of this study was to describe fundus autofluorescence (FAF), optical coherence tomography, and electroretinogram findings in choroidal sclerosis. Methods: This is a retrospective case series. Eight eyes of four patients with choroidal sclerosis were evaluated with FAF, optical coherence tomography, and electroretinogram testing. Results: In all eight eyes, FAF imaging showed hypofluorescent placoid lesions corresponding to areas of chorioretinal atrophy seen on stereo biomicroscopy. Prominent hyperfluorescent linear markings underlying regions of atrophic disease were observed in all eyes, likely representative of normal choroidal vessel autofluorescence. In two eyes, FAF showed punctate hypofluorescent lesions in the fovea that ... (Read Full Article)

      Comment on Article

    5. Optical coherence tomography in diabetic macular edema

      Explore Article LWW Online (Mar 14 2010) Ophthalmology

      Purpose of review: Because optical coherence tomography (OCT) has developed quite rapidly in recent years, the purpose of this review is to synthesize much of the recent literature on the use of OCT in the diagnosis and management of diabetic macular edema (DME). Recent findings: OCT has become increasingly utilized in clinical management and in research protocols in the approach to DME. Spectral domain OCT has given clinicians and researchers an even greater pathophysiologic understanding of DME. Summary: OCT has now added another quantitative dimension in the assessment of DME and could lead to better visual outcomes via earlier detection ... (Read Full Article)

      Comment on Article

    6. Can preoperative anterior chamber angle width predict magnitude of intraocular pressure change after cataract surgery?

      Explore Article NRC Research Press Publishing Services (Mar 13 2010) Ophthalmology

      Can preoperative anterior chamber angle width predict magnitude of intraocular pressure change after cataract surgery? Objective: To determine whether preoperative anterior chamber angle width, captured by anterior segment optical coherence tomography (AS-OCT), can be a predictor of intraocular pressure (IOP) change following cataract surgery. Design: Prospective comparative observational study. Participants: Fifty-three eyes of 53 patients awaiting cataract surgery were included. Methods: Measurement of anterior chamber angle width and IOP using AS-OCT and Goldmann’s applanation tonometry, respectively, were performed before and 6 months after phacoemulsification and intraocular lens implantation. Preoperative and postoperative measurements were compared using paired t test. The prediction rule defined success as ≥20% IOP reduction from the baseline preoperative IOP measurement. Multivariate regression ... (Read Full Article)

      Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Visante OCT

    7. Volcano Announces Activities at the ACC 2010

      Explore Article ptca.org (Mar 12 2010) Cardiology , Other Business News

      March 11, 2010 -- San Diego -- Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision intravascular therapy guidance tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, announced today its participation in the Annual Scientific Sessions of the American College of Cardiology (ACC) Conference from March 14th to March 16th in Atlanta, GA. "The Percutaneous Coronary Intervention (PCI) procedures that benefit from our technology are very complex, often involving multi-vessel disease, bifurcations, left mains, chronic total occlusions, intermediate lesions, or various combinations," commented Joe Burnett, Executive Vice President at Volcano. "Our message, ... (Read Full Article)

      Comment on Article Mentions:   GE Healthcare   Siemens   Volcano

    8. Volcano Expands Access to FFR with Ability to Integrate with the Majority of Hemodynamic Monitoring Systems

      Explore Article PR Newswire (Mar 12 2010) Cardiology , Other Business News

      SAN DIEGO, March 12 /PRNewswire-FirstCall/ -- Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision intravascular therapy guidance tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, announced today its Fractional Flow Reserve (FFR) technology can now integrate with the FFR modules of hemodynamic monitoring systems from GE, Siemens, McKesson, and Mennen. "Utilization of Volcano's physiology (functional measurement) products has grown 79% in the last year, driven primarily by the landmark FAME data and recent elevation of the level of evidence for FFR in the ACC/AHA/SCAI PCI Guidelines to Level A," commented Scott ... (Read Full Article)

      Comment on Article Mentions:   GE Healthcare   Siemens   Volcano

    9. Ultra-high speed full range complex spectral domain optical coherence tomography for volumetric imaging at 140,000 A scans per second

      Explore Article SPIE Digital Library (Mar 11 2010) Ophthalmology

      Ultra-high speed full range complex spectral domain optical coherence tomography for volumetric imaging at 140,000 A scans per second We demonstrate an ultra-high speed full rang spectral domain optical coherence tomography system based on CMOS camera at 140,000 A-scans per second. By implementing beam-offset method, a constant modulation frequency is introduced into each B-scan that enables the reconstruction of the full range complex SDOCT images from in vivo biological specimens. To make use of the full acquisition capacity of detection camera used in the system, we developed system control software that streams the raw spectral fringe data directly into the computer memory. The feasibly of our high speed full range SDOCT system is demonstrated for imaging the dynamics of ... (Read Full Article)

      Comment on Article Mentions:   Ruikang K. Wang   Lin An   Oregon Health & Science University

    10. Swings and roundabouts: Intravascular Optical Coherence Tomography (OCT) in the evaluation of the left main stem coronary artery

      Explore Article International Journal of Cardiology (Mar 11 2010) Cardiology

      The imaging detail provided by Intravascular Ultrasound (IVUS) has contributed to 2 recent advances in the treatment of atherosclerotic left main stem coronary artery disease. First, the imaging of stent strut expansion has contributed to an increasing acceptance of left main stem stenting as an alternative to surgery , and second, precise measurements of the plaque area and residual lumenal area have allowed for improved quantification of left main lesion severity . (Read Full Article)

      Comment on Article Mentions:   University of Sydney

    11. Correlation Between Morphologic Features on Spectral-Domain Optical Coherence Tomography and Angiographic Leakage Patterns in Macular Edema

      Explore Article LWW Online (Mar 11 2010) Ophthalmology

      Purpose: The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular edema, and vein occlusion. Methods: Eighty-seven consecutive patients (107 eyes) with macular edema from 5 different etiologies were imaged by simultaneous scanning laser ophthalmoscopy/OCT to study the morphologic patterns of edema on SD-OCT and then correlated/colocalized with the fluorescein angiographic patterns of leakage. Statistical analysis was done to analyze the differences in the morphologic OCT pattern by different diseases. Results: Spectral-domain OCT ... (Read Full Article)

      Comment on Article Mentions:   UCSD   Francesca Mojana   Igor Kozak

    12. Nanoshells for Photothermal Cancer Therapy

      Explore Article SpringerLink Home (Mar 11 2010) Oncology

      Nanoshells for Photothermal Cancer Therapy Cancer is a leading cause of death in the United States and contributes to yearly rising health care costs. Current methods of treating cancer involve surgical removal of easily accessible tumors, radiation therapy, and chemotherapy. These methods do not always result in full treatment of the cancer and can in many cases damage healthy cells both surrounding the tissue area and systemically. Nanoshells are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near-infrared (NIR) region where light transmits deeply into tissue. When injected systemically, these particles have been shown to accumulate in the tumor due ... (Read Full Article)

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    13. High Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration

      Explore Article iovs.org (Mar 11 2010) Ophthalmology

      Purpose: To investigate to use of high resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVM) associated with exudative age-related macular degeneration (eAMD). Methods: An Fd-OCT instrument with axial resolution of 4 to 4.5 µm and transverse resolution of 10 to 15 µm was used to image 21 eyes (19 subjects) with newly-diagnosed eAMD. A raster series of 100 B-scans separated by 60 µm was used study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed 3-dimensional macular volume. Results: A highly reflective subretinal ... (Read Full Article)

      Comment on Article Mentions:   UC Davis   Robert J. Zawadzki   Susanna S. Park

    14. Early trabeculectomy bleb walls on anterior-segment optical coherence tomography

      Explore Article SpringerLink Home (Mar 11 2010) Ophthalmology

      Early trabeculectomy bleb walls on anterior-segment optical coherence tomography Background To correlate the cross-sectional features of filtering blebs on anterior-segment optical coherence tomography (AS-OCT) 2 weeks after trabeculectomy with bleb function at 6 months. Methods Forty-eight eyes followed for 6 months or more after trabeculectomy with mitomycin C were included. Bleb wall reflectivity of developing blebs on AS-OCT 2 weeks postoperatively was correlated with mature bleb function at 6-month postoperative visit. Results Developing bleb walls at 2 weeks were classified as uniform in 10/48 eyes (20.8%) and multiform in 38/48 eyes (79.2%). Blebs with uniform reflectivity were significantly more likely to have worse function at 6 months (P < 0.001). Multiform ... (Read Full Article)

      Comment on Article Mentions:   Kyoto University Graduate School of Medicine   Masanori Hangai   Nagahisa Yoshimura

    15. MP learns about key issues for people with sight loss

      Explore Article politics.co.uk (Mar 11 2010) Ophthalmology

      At a recent Parliamentary reception, Andrew Miller, MP for Ellesmere Port and Neston, met blind and partially sighted campaigners who are working at local level to secure a better deal for people with sight loss. The event celebrated the work of the cross-party parliamentary group on Eye Health and Visual Impairment, which meets to raise parliamentarians' awareness of issues affecting people with sight loss and on prevention of sight loss. Andrew Miller said "On average around 3,000 people in every parliamentary constituency have sight loss. This was an excellent opportunity for me to learn about the equipment available to people ... (Read Full Article)

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