1. Recent Articles From Around The Web

    1. Temperature stabilized phase reference for MEMS based swept sources

      Temperature stabilized phase reference for MEMS based swept sources

      MEMS tunable lasers are not inherently phase stable because Brownian motion and drive electronics noise make the starting wavelength of the sweep unstable with respect to the electrical sweep trigger. A typical solution to the problem is to use a fiber Bragg reflector wavelength trigger. That is a sub-optimal solution since environmental changes can move both the Bragg peak and the k-clock phase. We have packaged temperature controlled trigger and clock etalons in a butterfly package to solve this environmental problem. By making the wide FSR trigger etalon from silicon and the narrow FSR clock etalon from fused silica, the ...

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    2. Distributed gas detection utilizing Fourier domain optical coherence based absorption spectroscopy

      Distributed gas detection utilizing Fourier domain optical coherence based absorption spectroscopy

      In this study, a new method called Fourier domain optical coherence based absorption spectroscopy (FD-OCAS) is proposed for distributed gas detection for the first time. Mach-Zehnder interferometer based quasi-distributed structure is developed for proof-concept demonstration and experimental verification. Optical interference happens between reference arm and sensing arms of the constructed Mach-Zehnder interferometer. Different sensing arms coded with different fiber lengths contribute different frequency components in ultimate interference signals. Fourier transform is used to separate each frequency to identify different sensing arms, realizing distributed detection. The amplitudes of Fourier transform are related to the gas absorption levels in corresponding sensing arms ...

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    3. Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant

      Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant

      Purpose The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls. Methods A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). We evaluated the conjunctival morphology of the eyes using AS-OCT. The main parameters evaluated were bleb height, sub-epithelial fibrosis, epithelial thickness, and changes in intraocular pressure (IOP). Results We found ...

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    4. Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Objective: To evaluate the potential utility of perfusion density measurements to discriminate patients with arterial hypertension by cardiovascular risk category. Methods: In this cross-sectional study, one eye per subject was evaluated (N = 73). The study cohort was divided into three groups according to the clinical criteria established by the European Guidelines for Arterial Hypertension: 26 controls, 24 patients with low cardiovascular risk, and 23 patients with very high cardiovascular risk. All patients were examined using RS-3000 Advance optical coherence tomography angiography to analyze macular and peripapillary perfusion density. Results: There were no differences among the three risk groups by sex ...

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    5. Assessment of strut coverage of everolimus-eluting platinum chromium stent 2 weeks after implantation by optical coherence tomography

      Assessment of strut coverage of everolimus-eluting platinum chromium stent 2 weeks after implantation by optical coherence tomography

      The SYNERGY coronary stent is new-generation drug-eluting stents, which has a thin-strut platinum–chromium platform with everolimus in a biodegradable polymer applied to the abluminal surface. It would be speculated that favorable arterial healing with early strut coverage could be achieved. The present study investigated the degree of strut coverage using optical coherence tomography (OCT) 2 weeks after SYNERGY implantation and clinical factors contributing to strut coverage. A total of 29 patients who underwent staged percutaneous coronary intervention (PCI) to residual lesions 2 weeks after the index PCI with SYNERGY stent implantation were enrolled. At the time of staged PCI ...

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      Mentions: Kenichi Fujii
    6. Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Image

      Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Image

      This study aimed to develop a machine learning-based algorithm for glaucoma diagnosis in patients with open-angle glaucoma, based on three-dimensional optical coherence tomography (OCT) data and color fundus images. In this study, 208 glaucomatous and 149 healthy eyes were enrolled, and color fundus images and volumetric OCT data from the optic disc and macular area of these eyes were captured with a spectral-domain OCT (3D OCT-2000, Topcon). Thickness and deviation maps were created with a segmentation algorithm. Transfer learning of convolutional neural network (CNN) was used with the following types of input images: (1) fundus image of optic disc in ...

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    7. Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography

      Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography

      Purpose To investigate the validity of a multiple regression equation to predict postoperative corneal curvature radius (K) in simultaneous cataract and pterygium surgery using preoperative factors, including preoperative K. Study design Retrospective study. Methods Seventy eyes of 58 patients who had undergone initial pterygium removal at the Hayashi Eye Hospital between June 2014 and December 2017 were included in this study. In all eyes, the shape of the cornea could be measured using anterior segment optical coherence tomography 2 months after surgery. The independent variables were determined using a multiple regression equation that predicted the average postoperative K on the ...

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    8. Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

      Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

      Aims To describe optical coherence tomography (OCT) findings in patients with in-stent restenosis (ISR) and determine predictors of neointimal patterns and neoatherosclerosis. Methods and results Patients undergoing OCT prior to PCI for ISR in three European centres were included. Analyses were performed in a core laboratory. Qualitative and quantitative [gray-scale signal intensity (GSI)] neointima analyses were performed on a per quadrant basis. A total of 107 patients were included. Predominantly homogeneous lesions included 4.5% (0.0–14.3) non-homogeneous quadrants, while predominantly non-homogeneous ones included 28.1% (20.3–37.5) homogeneous quadrants. Mean GSI values differed significantly between ...

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    9. Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging

      Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging

      Purpose To determine the effects of averaging five en face optical coherence tomography angiographic (OCTA) images on the quality of the images in eyes with a choroidal neovascularization (CNV). Methods Twenty-seven eyes of 25 patients (18 men, 7 women; average age 71.0 years) with a CNV were examined by OCTA (OCT HS-100, Canon. Japan). A 3 × 3-mm image including the CNV was recorded and automatically segmented between the retinal outer layers. Analyses were performed on a single image (S-image) and the average of five single images of the same area (A-images). The region of the CNV was selected by ...

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    10. Quantitative assessment of outer retinal folds on enface optical coherence tomography after vitrectomy for rhegmatogenous retinal detachment

      Quantitative assessment of outer retinal folds on enface optical coherence tomography after vitrectomy for rhegmatogenous retinal detachment

      We aimed to investigate the possible causes of metamorphopsia for rhegmatogenous retinal detachment (RRD) based on findings of enface optical coherence tomography (OCT). The study was a retrospective, consecutive case series of 33 eyes with macula-off RRD. Metamorphopsia was measured by M-CHARTS and enface OCT images covering a macular area of 6 × 6 mm square obtained at 1, 3, and 6 months postoperatively. Within the outer retinal slabs of enface OCT, multiple lines that looked like folds were delineated in all eyes at month 1, and we succeeded in extracting images of folds by subtracting retinal vessels. We calculated their ...

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      Mentions: Hiroshi Ishikawa
    11. Optical coherence tomography imaging in keratoconus

      Optical coherence tomography imaging in keratoconus

      Invited Review: Optical coherence tomography (OCT) is being increasingly used as a tool in the diagnosis and management of keratoconus. While elevation‐based topography remains essential, there is an expanding role for cross‐sectional OCT imaging in the diagnosis of the disease. Images and measurements of corneal thickness, and in particular, epithelial thickness, may be important in diagnosing early cases, and following procedures such as intrastromal corneal ring segments, corneal transplants and corneal collagen cross‐linking.

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    12. Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Remineralizing Potential of Nano-Silver-Fluoride for Tooth Enamel: An Optical Coherence Tomography Analysis

      Objective: To evaluate the use of nanosilver fluoride in the enamel remineralization process through optical coherence tomography . Material and Methods: All samples were submitted to demineralization process by pH cycling during 14 days and randomly distributed into three groups (n = 11): Nanosilver Fluoride (NSF), Sodium fluoride (NaF), and negative control. Optical coherence tomography images were acquired at three different moments: initial stage (T0), post caries formation (T1), and post pH cycling (T2). The integrity of the enamel surface and the measurement of the volume loss for the tissue after pH cycling in comparison to initial images were obtained from optical ...

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    13. Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma

      BACKGROUND AND OBJECTIVE: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH). PATIENTS AND METHODS: A case series of eight patients diagnosed with IRAH. RESULTS: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions. Fundus autofluorescence (FAF) changes were seen in all eight cases. Ocular ultrasound was able to identify a lesion in only five of the seven cases. Optical coherence tomography ...

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  2. Organizations in the News

    1. (2 articles) UCLA
    2. (2 articles) National Institutes of Health
    3. (2 articles) University of Tsukuba
    4. (2 articles) Massachusetts General Hospital
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    6. (2 articles) VU University Amsterdam
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  3. People in the News

    1. (2 articles) Yoshiaki Yasuno
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  4. OCT Companies in the News

    1. (3 articles) Carl Zeiss Meditec
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  5. Picture Gallery

    Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR Soliton microcomb based spectral domain optical coherence tomography BiOS Hot Topics: Changing of the Guard Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients System Engineer Opening at Heidelberg Engineering in Lübeck Germany Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo SPECTRALIS OCT2 Module Improves Speed and Efficiency on the International Space Station Toward a multimodal fusion of layered cultural object images: complementarity of optical coherence tomography and terahertz time-domain imaging in the heritage field Temperature stabilized phase reference for MEMS based swept sources
  6. Recent Quotes

    1. This is the largest meeting in the world for biomedical optics, and that's because of you!
      By Rox Anderson
    2. Rox and I would like to take this opportunity to thank SPIE, program track chairs, conference chairs, and all of you in the com¬munity for the opportunity and the privilege to serve as co-chairs of BiOS all these years.
      By James G. Fujimoto
    3. Among the developments in the past 2 years, OCTA is by far the most important...Clinically, OCTA represents a paradigm change in angiography. It requires no dye injection, is faster (no waiting for dye transit), noninvasive, cheaper, and it can be used at every visit for screening and monitoring. OCTA will be used a lot more that fluorescein angiography ever was.
      By David Huang
    4. ATS9130 is a continuation of our effort to provide cost-effective yet powerful products to OEMs...ATS9130 provides data streaming, a feature that is usually absent in products in this price range.
      By Muneeb Khalid
    5. We see the power of OCT being utilized in several new areas, and appropriate software development tools are essential to speed up that progress. This software platform is a critical step in reaching our mission of OCT for all.
      By Nishant Mohan
    6. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      By Jay S. Duker
    7. The SBIR program democratizes funding for emerging companies, providing critical financial resources to regions of the country that may not have access to the venture capital of the major metropolitan areas.
      By Eric L. Buckland
    8. The VEGA series swept source OCT imaging systems have proven to be an excellent tool for a multitude of imaging applications. With this system series update, we aimed to increase the performance and ease of use for customers...The OCT applications team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    9. It’s an interesting time in this market...Level 4 and 5 autonomy needs a level of performance, range, resolution, frame rate, and immunity that legacy ToF sensors just can’t deliver. Couple that to cost goals that can only be met with a true all-semiconductor solution and you see the challenge. We have the huge advantage that we’ve been designing and manufacturing the core technology in this FMCW LiDAR sensor for more than 10 years.
      By Michael P. Minneman
    10. The initiation of our first U.S. based home OCT clinical trial is an important step towards bringing this leading-edge technology to eAMD patients, their caregivers, and the eye care community...Our collaboration with Wasatch Photonics will continue to be instrumental to our organization as the U.S. Food and Drug Administration (FDA) recently granted our Home Optical Coherence Tomography (OCT) System with ‘Breakthrough Device Designation’, a program designed to expedite patient access to novel technologies.
      By Susan Orr