1. Recent Articles From Around The Web

    1. Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook)

      Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook)

      Semiconductor lasers are small, reliable, low cost, high-performance and user-friendly optical devices which make them highly suitable for a variety of biomedical applications. This edited book gathers experts in the field to cover the fundamentals and technology advances of semiconductor lasers and diode-based lasers with a focus on their applications in medical optics and biophotonics including edge-emitting semiconductor lasers and light emitting diodes, Q-switched and mode-locked lasers, quantum cascade lasers, semiconductor disk lasers, near-infrared spectroscopy systems for biomedical applications, bio-medical Raman spectroscopy, nonlinear imaging and optical coherence tomography.

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    2. Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis

      Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis

      Background This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME). Methods This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behçet uveitis. The main outcome measure was comparison of mean CMT and MV with the types of Behçet uveitis. Results Sixty ...

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    3. Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography

      Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography

      Purpose We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye. Methods We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 µm, while group B had a size of ≥400 µm. Repeatability was determined by comparing the thicknesses of the GCIPL ...

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    4. Line-field confocal time-domain optical coherence tomography with dynamic focusing

      Line-field confocal time-domain optical coherence tomography with dynamic focusing

      A time-domain optical coherence tomography technique is introduced for high-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. Quasi-isotropic spatial resolution of 1.3 µm × 1.1 µm (lateral × axial) is achieved. In vivo cellular-level resolution imaging of human skin is demonstrated at 10 frames per second with a penetration depth of ∼500 µm.

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      Mentions: Arnaud Dubois
    5. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Purpose To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort. Results 164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more ...

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    6. Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

      Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography

      Purpose To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA). Methods Sixty-two children with OSAS (124 eyes; 5.94 ± 1.64 years old; 53.2% boys) were enrolled in this study. Their retinal vascular network density indices, including vascular diameter (VD), vascular area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI) on the macular superficial/deep capillary plexus (SCP/DCP), and the size of the foveal avascular zone (FAZ) were analyzed by OCTA before treatment and ...

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    7. Optical coherence tomography imaging of melanoma skin cancer

      Optical coherence tomography imaging of melanoma skin cancer

      No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Two ...

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    8. COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER

      COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER

      Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP. Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Results: The intraocular pressure at 1 hour and 6 hours after PRP was significantly raised in both groups. Mean intraocular pressure was 21.17 ± 4 ...

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    9. Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Purpose : To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA). Methods : Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Based on clear decorrelation signals, four vascular slabs were segmented, comprising one each in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and top and bottom of the inner nuclear layer (INL). Qualitative features and quantitative measurements in each slab ...

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    10. Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Background Despite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements. Methods Cross sectional observational cohort study. Subjects with normal eyes were recruited. Two sets of optical coherence tomography angiography images of macula and optic nerve head were acquired during one visit. Novel in-house developed software was used to count the pixels in each images and to ...

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    11. Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      In this Letter, we propose a beam-shifting optical coherence tomography scheme for speckle reduction and blood flow rate calculation, where variations of the speckle pattern and Doppler angle were generated by parallel shifting of the sample beam incident on the objective lens. The resultant optical coherent tomography images could then be averaged for speckle noise reduction and simultaneously analyzed for flow rate measurement. The performance of the proposed technique was verified by both phantom and in vivo experiments.

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    12. Axsun Technologies Announces Definitive Agreement to be acquired by Excelitas Technologies

      Axsun Technologies Announces Definitive Agreement to be acquired by Excelitas Technologies

      Axsun Technologies Inc., an Anzu Partners portfolio company, today announced that it has signed a definitive agreement to be acquired by Excelitas Technologies ® Corp., a global technology leader focused on delivering innovative, customized photonic solutions. The terms of the agreement are not being disclosed and the transaction is expected to close in early 2019. Jonathan Hartmann , CEO of Axsun, commented, "This is an outstanding opportunity for Axsun, our customers, and our employees as we continue to expand our product line and develop new markets together with Excelitas." "Our partnership with Anzu Partners has been outstanding, and we are grateful for ...

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    13. Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) criteria and clinical data with pathology of the vitreomacular interface (VMI) in eyes with diabetic macular edema (DME). Design Retrospective cross-sectional study and laboratory investigation. Methods We included specimens of 27 eyes of 26 patients with center-involved DME that underwent vitrectomy with peeling of the internal limiting membrane (ILM). Selection of specimens was consecutive and in retrospect using our register of the Vitreoretinal Pathology Unit. Clinical data and SD-OCT examinations were correlated to immunocytochemistry and transmission electron microscopy. Classification of DME comprised sponge-like diffuse retinal thickening, cystoid macular edema, and serous retinal ...

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  2. Organizations in the News

    1. (2 articles) Harvard University
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  3. People in the News

    1. (2 articles) Guillermo J. Tearney
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  4. OCT Companies in the News

    1. (2 articles) Axsun Technologies
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  5. Picture Gallery

    Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice Moody's says Excelitas' proposed $80 million first lien term loan facility to acquire Axsun is a moderate credit negative; ratings unaffected Mid-infrared Fourier-domain optical coherence tomography with a pyroelectric linear array Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples Direct comparison of optical coherence tomography and high-definition 60-MHz intravascular ultrasound imaging of intra-procedural stent thrombosis in a patient with acute coronary syndrome Opening for Technology Director – Core Products at Volk Optical Inc. Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane Notal Vision Announces FDA Grants Breakthrough Device Designation for Pioneering Patient-Operated Home Optical Coherence Tomography (OCT) System Intravascular Optical Coherence Tomography for Neurointerventional Surgery Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance
  6. Recent Quotes

    1. The initiation of our first U.S. based home OCT clinical trial is an important step towards bringing this leading-edge technology to eAMD patients, their caregivers, and the eye care community...Our collaboration with Wasatch Photonics will continue to be instrumental to our organization as the U.S. Food and Drug Administration (FDA) recently granted our Home Optical Coherence Tomography (OCT) System with ‘Breakthrough Device Designation’, a program designed to expedite patient access to novel technologies.
      By Susan Orr
    2. Our tests verified that a greatly reduced amount of experimental data can be used to reconstruct reasonable 3-D OCT images...After we perform enough experiments to demonstrate that our probe and imaging method are useful for observing malignant features, our technique will be ready for clinical trials...This work is just one example of applying computational techniques to imaging applications...We expect that similar approaches may be helpful for improving the experiment designs and data acquisition for many imaging modalities.
      By Jigang Wu
    3. Our goal with this work is to help develop a faster, more efficient and less invasive diagnostic and treatment pathway for melanoma. Patients with advanced disease should get aggressive treatment as quickly as possible; also those with early-stage melanomas should not have to undergo expensive invasive Sentinel Lymph Node Biopsy operations if their melanoma is reliably confirmed as very low-risk. We believe Dynamic OCT imaging could help with these goals and the results of this study are very encouraging. The next stage of our work is to analyse the link between vessel shapes and the actual degree of metastasis of the melanomas in a larger cohort, and not just the Breslow depth.
      By Julia Welzel
    4. When the heart develops, it becomes stiffer as required for ability to contract and pump blood...So the question is - does it become stiff because it's contracting, or is it stiff to begin with because it is genetically predefined?
      By Kirill V. Larin
    5. One out of every 100 babies in the United States has a congenital heart defect leading to death...Understanding biomechanical regulation of heart development is highly important for better management of congenital heart defects.
      By Irina V. Larina
    6. The clearance of the IRIS product marks the successful culmination of a multi-year development effort within our organization, and with the Food and Drug Administration...This product is something we at NinePoint, and our customers, are very excited to bring to market. We pride ourselves in customer responsiveness and innovation, key inputs to this new product. We are eager to roll this out in a controlled-market release in the coming months prior to making the technology more broadly available.
      By Eman Namati
    7. The announcement of Japan Lifeline applying for regulatory approval is an important commercial event for the company. Intravascular imaging is used frequently in the 260,000 angioplasty and stenting procedures performed every year in Japan. The Novasight Hybrid system is uniquely able to simultaneously acquire inherently co-registered IVUS and OCT images. I have been fortunate to work with a number of cardiologists in Japan whose experience and knowledge of intravascular imaging is incredibly profound. The input that we have received from Japanese physicians in the development of our product has been incredibly valuable in ensuring that our technology fits well with their clinical needs.
      By Brian K. Courtney
    8. We appreciate Novartis Pharma AG’s commitment to advancing development of a practical device that will enable patients to monitor progression of vision-threatening retinal diseases at home...Home monitoring and rapid reporting of results to treating physicians has the potential to dramatically transform this burdensome patient care model. Most importantly, it will help patients around the world get the full benefit of today’s sight-saving therapies.
      By Don Bogue
    9. The patient-focused goals of this Compact Imaging/Novartis collaboration complement Novartis’ efforts to introduce new anti-VEGF therapeutics for active AMD and DME that will reduce the frequency of injections, extend the time between follow-up visits and provide physicians new tools to help manage these serious chronic conditions...Clinically useful data on retinal disease progression from home monitoring devices also could prove extremely valuable in optimizing drug dosing and future drug development.
      By Michael R. Hee
    10. The addition of OCT angiography to Heidelberg’s SPECTRALIS multimodal platform allows for the evaluation of retinal and choroidal vascular abnormalities in a noninvasive manner...I believe OCTA will soon become invaluable in our daily clinical routine for screening and diagnosing chorioretinal disorders.”
      By Nadia K. Waheed