1. Recent Articles From Around The Web

    1. The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT

      Purpose To determine whether retinal nerve fiber layer (RNFL), macula and macular ganglion cell layer (mGCL)-inner plexiform layer (IPL) thickness differ in the amblyopic and normal fellow eyes of unilateral amblyopic patients using spectral domain optical coherence tomography (SD-OCT). Methods 80 patients with 160 eyes were included in this study; the distribution of patients was 17 patients with strabismic amblyopia, 17 patients with strabismic non-amblyopia, 23 patients with anisometropic amblyopia, and 23 patients with anisometropic non-amblyopia. Macular, RNFL, and mGCL-IPL thickness were obtained by SD-OCT, and the interocular thickness differences of each group were analyzed. After treatment, the changes ...

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    2. Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Macular Choroidal Thickness and Volume Measured by Swept-source Optical Coherence Tomography in Healthy Korean Children

      Purpose To evaluate the thickness and volume of the choroid in healthy Korean children using swept-source optical coherence tomography. Methods We examined 80 eyes of 40 healthy children and teenagers (<18 years) using swept-source optical coherence tomography with a tunable long-wavelength laser source. A volumetric macular scan protocol using the Early Treatment Diabetic Retinopathy Study grid was used to construct a choroidal thickness map. We also examined 44 eyes of 35 healthy adult volunteers (≥18 years) and compared adult measurements with the findings in children. Results The mean age of the children and teenagers was 9.47 ± 3.80 (4 ...

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    3. Interferometric system based on swept source-optical coherence tomography scheme applied to the measurement of distances of industrial interest

      Interferometric system based on swept source-optical coherence tomography scheme applied to the measurement of distances of industrial interest

      We used an interferometric technique based on typical optical coherence tomography (OCT) schemes for measuring distances of industrial interest. The system employed as a light source a tunable erbium-doped fiber laser of ∼ 20 - pm ∼20-pm bandwidth with a tuning range between 1520 and 1570 nm. It has a sufficiently long coherence length to enable long depth range imaging. A set of fiber Bragg gratings was used as a self-calibration method, which has the advantage of being a passive system that requires no additional electronic devices. The proposed configuration and the coherence length of the laser enlarge the range of maximum ...

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    4. A robust fully automatic lumen segmentation method for in vivo intracoronary optical coherence tomography

      A robust fully automatic lumen segmentation method for in vivo intracoronary optical coherence tomography

      Introduction: Intravascular optical coherence tomography (IVOCT) is an in-vivo imaging modality based on the introduction of a catheter in a blood vessel for viewing its inner wall using electromagnetic radiation. One of the most developed automatic applications for this modality is the lumen area segmentation, however on the evaluation of these methods, the slices inside bifurcation regions, or with the presence of complex atherosclerotic plaques and dissections are usually discarded. This paper describes a fully-automatic method for computing the lumen area in IVOCT images where the set of slices includes complex atherosclerotic plaques and dissections. Methods The proposed lumen segmentation ...

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    5. Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis

      Purpose To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. Case summary Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in ...

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    6. Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems

      PURPOSE: To compare corneal thickness measurements between three imaging systems. METHODS: In this retrospective study of 81 virgin and 58 post-laser refractive surgery corneas, central and minimum corneal thickness were measured using optical coherence tomography (OCT), very high-frequency digital ultrasound (VHF digital ultrasound), and a Scheimpflug imaging system. Agreement between methods was analyzed using mean differences (bias) (OCT – VHF digital ultrasound, OCT – Scheimpflug, VHF digital ultrasound – Scheimpflug) and Bland–Altman analysis with 95% limits of agreement (LoA). RESULTS: Virgin cornea mean central corneal thickness was 508.3 ± 33.2 µ m (range: 434 to 588 µ m) for OCT, 512.7 ± 32 ...

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    7. Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Repeatability and Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements of Retinal Thickness in Rats

      Purpose : To evaluate the in vivo repeatability and reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurements of total retinal thickness (TRT) and retinal nerve fiber layer (RNFL) thickness in rats. Methods : Retinal thickness was measured using an RNFL circular scan with AutoRescan and TruTracking modes in 20 eyes of Long-Evans Tokushima Otsuka rats. Three RNFL circular scan images were acquired with a brief rest between measurements to evaluate intra-session repeatability. Three additional RNFL circular scans were acquired 1 day later to evaluate intersession repeatability. Two experienced examiners independently measured TRT using automatic alignment and RNFL thickness using manual alignment according ...

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    8. Detecting early stage osteoarthritis by optical coherence tomography?

      Detecting early stage osteoarthritis by optical coherence tomography?

      Osteoarthritis (OA) is the most common chronic disease of our joints, manifested by a dynamically increasing degeneration of hyaline articular cartilage (AC). While currently no therapy can reverse this process, the few available treatment options are hampered by the inability of early diagnosis. Loss of cartilage surface, or extracellular matrix (ECM), integrity is considered the earliest sign of OA. Despite the increasing number of imaging modalities surprisingly few imaging biomarkers exist. In this narrative review, recent developments in optical coherence tomography are critically evaluated for their potential to assess different aspects of AC quality as biomarkers of OA. Special attention ...

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    9. Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Macular Thickness in Myopia: An OCT Study of Young Chinese Patients

      Purposes : To investigate macular thickness (MT) in young myopic Chinese patients using Spectralis optical coherence tomography (OCT) and to assess its association with gender, axial length (AL), spherical equivalent (SE), and intraocular pressure (IOP). Methods : Included in this study were 133 myopic Chinese patients, aged 18–30 years. All underwent complete ophthalmic examinations and Spectralis OCT. Inner, central, and outer foveal regions of the macula were measured. Results : The central fovea was the thinnest of the three macular regions (mean thickness, 250.1 ± 15.3 μm). Women had consistently thinner MTs than did men, except in the outer superior and ...

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    10. Optical Coherence Tomography scanner a boon to basal-cell diagnosis

      Optical Coherence Tomography scanner a boon to basal-cell diagnosis

      Clinical trials in the U.S. have now shown that multi-beam Optical Coherence Tomography (‘OCT’) technology, may make diagnosis cut-free and immediate, according to English medical device company Michelson Diagnostics. In a multi-center study, its VivoSight OCT scanner, has been shown to significantly improve diagnosis of basal-cell carcinoma at an earlier stage and cut biopsies by 36 percent. The paper about this study appeared in the Journal of Clinical and Aesthetic Dermatology .

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    11. Laser Zentrum Hannover develops presbyopia laser surgery model

      Laser Zentrum Hannover develops presbyopia laser surgery model

      A research effort involving Laser Zentrum Hannover (LZH) in Germany is developing a new, laser-based treatment for presbyopia – the condition that impacts near vision in people from around the age of 40 onwards. At the moment presbyopia – caused by the age-related stiffening of the lens in those affected – is usually treated with simple solutions like reading or bifocal glasses, with multi-focal contact lenses from the likes of Bausch + Lomb becoming available more recently. Some laser procedures have also been developed, but if successful the LZH-led project could lead to a "gentle" new femtosecond laser technique that makes tiny cuts in ...

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    12. A Comparison of Intravascular Imaging Modalities for Detection of Stent Struts in Acute Coronary Syndrome

      A Comparison of Intravascular Imaging Modalities for Detection of Stent Struts in Acute Coronary Syndrome

      Background We used optical coherence tomography (OCT) and intravascular ultrasound (IVUS) to assess the struts of implanted stents in patients with acute coronary syndrome (ACS). Methods A totle of 10,756 stent struts were analyzed with OCT in 42 patients of ACS. Of them, both of IVUS and OCT imaging were performed in 33 patients. Appearance of stent struts was classified as well apposed, buried, malapposed, and nondetectable, and the number of stent struts were counted by OCT and IVUS was compared. Results Most of stent struts were well apposed (78.1%, 8,407/10,756). However, malapposed struts were ...

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    13. Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300–1700-nm

      Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300–1700-nm

      Background and objectives Current clinical methods for diagnosing secondary caries are unreliable for identifying the early stages of decay around restorative materials. The objective of this study was to access the integrity of restoration margins in natural teeth using near-infrared (NIR) reflectance and transillumination images at wavelengths between 1300 and 1700-nm and to determine the optimal NIR wavelengths for discriminating composite materials from dental hard tissues. Materials and methods Twelve composite margins ( n = 12) consisting of class I, II and V restorations were chosen from ten extracted teeth. The samples were imaged in vitro using NIR transillumination and reflectance, polarization ...

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    14. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Purpose To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). Methods A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were randomly chosen to be scanned by two operators for reproducibility analysis. Distribution of optical intensity of each layer and regions specified by the Early Treatment of Diabetic Retinopathy Study (ETDRS) were investigated by analyzing the OCT raw data with our automatic graph-based algorithm. Univariate and multivariate analyses were ...

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    15. Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      Zeiss AngioPlex Optical Coherence Tomography Angiography of the Retinal Microvasculature May Help Enhance Understanding of Retinal Diseas

      AngioPlexTM optical coherence tomography (OCT) is a new approach to diagnostic imaging in retinal disease. This technology uses amplitude and phase aspects of the OCT signal and novel algorithms to enable highly detailed visualisation of the retinal microvasculature. This system detects capillary flow rather than the presence of an injected dye. Unlike fluorescein angiography (FA), AngioPlex OCT imaging can discriminate capillaries at the superficial and deep retina and can also generate a colour map of the retinal vessels providing unparalleled views of diseased capillaries and net structures. Retinal and choroidal pathologies that are amenable to AngioPlex OCT examination include diabetic ...

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      Mentions: FDA
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    Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography Functional optical coherence tomography of rat olfactory bulb with periodic odor stimulation Compact Imaging/NUI Galway Research Featured  At Global Photonics Conference in San Francisco Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling Complex master slave interferometry St. Jude Medical Announces Launch of OPTIS Mobile System in Europe and Japan Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis Optovue Releases AngioAnalytics, World's First OCTA Blood Vessel Measurement Technology Use of intravascular ultrasound vs. optical coherence tomography for mechanism and patterns of in-stent restenosis among bare metal stents and drug eluting stents Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study Determination of a material characteristic with the use of second-order photon correlation
  7. Recent Quotes

    1. In the field of OCT imaging and biometry, size, price and operating power are three critical elements to commercialization in mass market applications...Our MRO system is the first version of OCT with the size, cost and operating power profile to address high volume applications in areas such as mobile personal health monitoring and biometric security.
      By Don Bogue
    2. The clinical benefit to the patient and the work flow to clinics have been a major impact to society.
      By Jay Wei
    3. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      By David Huang
    4. “Now we’re at a precipice of potentially a new frontier...This technology means that retina doctors are “seeing things we never thought we would see” and “seeing things maybe we don’t even know how to interpret.
      By Peter K. Kaiser
    5. This is a newsworthy application for those working in the ICU..."Infection is an ever-present risk, and an easier way to check for biofilm could see such checks done more often and infection rates lowered, which would be a great outcome.
      By David D. Sampson
    6. With the angiography function, physicians can visualize the blood vessels of the retina in 3D...Contrary to conventional angiography, this procedure does not require the use of contrast media, which is a decisive clinical advantage.
      By Ludwin Monz
    7. We are very excited to receive clearance to introduce the EnFocus intrasurgical OCT system, which provides ophthalmic surgeons with highly resolved, real-time, deep and wide-field images for use during ophthalmic surgery...This product introduction builds upon Bioptigen’s 10-year history of delivering advanced OCT imaging tools to the ophthalmic healthcare community.
      By Eric L. Buckland
    8. The inexpensive, very small, robust portable diagnostic system for oral cancer based on OCT will be used to screen for oral cancer in the field by basic level healthcare workers in India, and a simple diagnostic algorithm will indicate further diagnostic and treatment needs for each individual.
      By Petra E. Wilder-Smith
    9. AngioVue technology has given physicians, for the first time, the ability to visualize blood vessels in the individual layers of the retina, without injections of dye...This visualization information provides physicians with a compelling new way to manage patients affected by wet age-related macular degeneration, a leading cause of blindness. We expect similar contributions to the management of diabetic retinopathy, the leading cause of blindness in diabetic patients.
      By Jay Wei
    10. Any state of disease will alter the cells and molecules in our body...leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave alone.
      By Stephen A. Boppart