1. Featured Articles

    1. Feasibility and Safety of the Novel Vivolight Frequency Domain Optical Coherence Tomography System: A Multicenter Study

      Explore Invasive Cardiology Cardiology
      Feasibility and Safety of the Novel Vivolight Frequency Domain Optical Coherence Tomography System: A Multicenter Study

      Objective. The study sought to assess the effectiveness and safety of the novel P60 Vivolight frequency-domain optical coherence tomography (OCT) system (Shenzhen Vivolight Medical Device & Technology). Methods. A total of 90 patients were enrolled from 3 institutions. The pullbacks were performed with both the P60 Vivolight OCT system and the Ilumien Optis OCT system (Abbott Vascular). The primary endpoint was the clear stent length (CSL). Device safety was assessed by the record of serious procedure-related or postprocedure adverse events. The secondary endpoints were the average lumen area of stent, clear image length (CIL), system stability, and imaging catheter operability. Results ...

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      Mentions: Vivolight

    2. First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI

      Patients will undergo intracoronary imaging using combined optical coherence tomography- fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary intervention, and the obtained imaging data will be used to assess the efficacy of this dual-modal catheter imaging strategy in characterizing high-risk plaque.

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      Mentions: Korea University

    3. Postdoctoral Research Fellow position at Legacy Devers Eye Institute – Discoveries in Sight

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral Research Fellow position at Legacy Devers Eye Institute – Discoveries in Sight

      A Postdoctoral Research Fellow position is available at Legacy Devers Eye Institute, Portland, Oregon. The successful candidate will be responsible for planning and carrying out independent research under the supervision of Dr. Kazuhiro Kurokawa and collaborating with Discoveries in Sight Scientists. Research involves developing a versatile, high-resolution, in vivo retinal imaging system capable of cellular-scale imaging at any depth in the retina and detecting various metrics even at a nanometer scale. Advances in imaging technology allow us to study key hypotheses that require accurate and precise measurements. For further detail, please contact me directly.

      Keywords: AO-OCT, polarization contrast, angiography, cellular ...

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      Mentions: Devers Eye Institute

    4. Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      Explore Nature Publishing Group Gynecology
      Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

      In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were ...

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      Mentions: Zhengzhou Ultralucia Medical Technology Co., Ltd

    5. Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      Explore OSA | OSA Publishing Ophthalmology
      Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      An accurate and automated tissue segmentation algorithm for retinal optical coherence tomography (OCT) images is crucial for the diagnosis of glaucoma. However, due to the presence of the optic disc, the anatomical structure of the peripapillary region of the retina is complicated and is challenging for segmentation. To address this issue, we develop a novel graph convolutional network (GCN)-assisted two-stage framework to simultaneously label the nine retinal layers and the optic disc. Specifically, a multi-scale global reasoning module is inserted between the encoder and decoder of a U-shape neural network to exploit anatomical prior knowledge and perform spatial reasoning ...

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      Mentions: Shanghai Jiao Tong University

    6. Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid–structure interaction models and machine learning methods with patient follow-up data: a feasibility study

      Explore BioMedical Engineering OnLine Cardiology
      Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid–structure interaction models and machine learning methods with patient follow-up data: a feasibility study

      Background Coronary plaque vulnerability prediction is difficult because plaque vulnerability is non-trivial to quantify, clinically available medical image modality is not enough to quantify thin cap thickness, prediction methods with high accuracies still need to be developed, and gold-standard data to validate vulnerability prediction are often not available. Patient follow-up intravascular ultrasound (IVUS), optical coherence tomography (OCT) and angiography data were acquired to construct 3D fluid–structure interaction (FSI) coronary models and four machine-learning methods were compared to identify optimal method to predict future plaque vulnerability. Methods Baseline and 10-month follow-up in vivo IVUS and OCT coronary plaque data were ...

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      Mentions: Cardiovascular Research Foundation Boston Scientific Washington University in St. Louis

    7. Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography

      Explore American Physiological Society Journal Neurology
      Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography

      Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction contribute importantly to the pathogenesis of both vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). Recent advances in geroscience research enable development of novel interventions to reverse age-related alterations of the cerebral microcirculation for prevention of VCID and AD. To facilitate this research, there is an urgent need for sensitive and easy-to-adapt imaging methods that enable longitudinal assessment of changes in BBB permeability and brain capillarization in aged mice and that could be used in vivo to evaluate treatment efficiency. To enable longitudinal assessment of changes in BBB permeability ...

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    8. Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers

      Explore Frontiers
      Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers

      We developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them using high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This technology integrates our custom-built ultra-high resolution endoscopic three-dimensional OCT diagnostic imaging device with a commercial high dose rate brachytherapy system (HDR), resulting in a compact, portable, easy-to-operate, and low-cost Endo-OCT image-guided high dose rate brachytherapy (OCT-IGHDR) system. The system has the dual functions of diagnosis and treatment that can precisely detect and measure the location and size of the early-stage pancreatic cancer or premalignant lesions and ...

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      Mentions: The Ohio State University

    9. 900 Specsavers stores install OCT

      Explore Optical Coherence Tomography News Other Business News
      900 Specsavers stores install OCT

      Ensuring the latest optical technology is accessible to as many people as possible. Specsavers has today announced its 900th store location in the UK and Ireland to install an Optical Coherence Tomography (OCT ) as Selby in Yorkshire. The technology is used as part of Specsavers’ most advanced eye test. The landmark has been achieved four years after the company announced the commitment to a £35 million pound investment. Since 2017, Specsavers stores have been installing OCT scanners, backed up by an extensive training and mentoring programme for all optical colleagues. This nationwide rollout allow s most Specsavers optometrists to work ...

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      Mentions: Specsavers

    10. Advantage of low NEP balanced receivers in swept source OCT

      Explore SPIE Digital Library
      Advantage of low NEP balanced receivers in swept source OCT

      Low NEP balanced receivers generally do not result in better sensitivity in a shot-noise-limited swept source OCT system. However, there is an advantage if RIN is significant. A lower NEP, even in the shot-noise-limited case, does allow for lower reference arm powers. This, in turn, reduces fixed pattern artifact signals caused by stray optical component reflections inside a swept source laser cavity. An NEP reduction of √10 allows the reference power to be reduced 10 dB while maintaining SNR. This reduces the pattern to noise ratio by 10 dB because pattern noise is directly detected (20 dB scaling per decade ...

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      Mentions: Axsun Technologies

    11. OCT applications in optics R&D and manufacturing

      Explore SPIE Digital Library
      OCT applications in optics R&D and manufacturing

      Optical coherence tomography (OCT) can be an important diagnostic tool in optics R&D and manufacturing. We illustrate this with four applications. (1) Imaging of vibration modes of MEMS membranes. (2) Strain mapping of VCSEL chips. (3) Optical frequency domain reflectometry (OFDR) of laser cavities. (4) Combined responsivity and 3D mapping of photodiode packages.

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      Mentions: Axsun Technologies

    12. Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

      Explore Home - Springer
      Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

      We present an overview of recent results on optical coherence tomography with the use of extreme ultraviolet and soft X-ray radiation (XCT). XCT is a cross-sectional imaging method that has emerged as a derivative of optical coherence tomography (OCT). In contrast to OCT, which typically uses near-infrared light, XCT utilizes broad bandwidth extreme ultraviolet (XUV) and soft X-ray (SXR) radiation (Fuchs et al in Sci Rep 6:20658, 2016). As in OCT, XCT’s axial resolution only scales with the coherence length of the light source. Thus, an axial resolution down to the nanometer range can be achieved. This is ...

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    13. Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural ...

      Explore OSA | OSA Publishing Gastroenterology , Probes , Tunable Sources
      Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural ...

      Swept source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure. However, applications requiring wide fields of view (FOV), rapid imaging, and higher resolutions have been challenging because multi-MHz axial scan (A-scan) rates are needed. We describe a microelectromechanical systems vertical cavity surface-emitting laser (MEMS-VCSEL) SS-OCT technology for A-scan rates of 2.4 and 3.0 MHz. Sweep to sweep calibration and resampling are performed using dual channel acquisition of the OCT signal and a Mach Zehnder interferometer signal, overcoming inherent optical clock limitations and enabling higher performance. We demonstrate ultrahigh speed structural SS-OCT and OCT angiography (OCTA) imaging ...

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      Mentions: Massachusetts Institute of Technology National Institutes of Health Thorlabs

    14. Thorlabs’ OCT Team Presents a Webinar detailing the use cases and technology differences for Swept Source and Spectral Domain OCT Systems – March 31st, 2021

      Explore Optical Coherence Tomography News
      Thorlabs’ OCT Team Presents a Webinar detailing the use cases and technology differences for Swept Source and Spectral Domain OCT Systems – March 31st, 2021

      This free, live event will take place on March 31 at 11 am EDT (5 PM CET) and will include an interactive Q&A session. For information and to register please visit this link . After the event a recorded version will be available at www.thorlabs.com/webinars . Abstract: Drs. Sebastian Schäfer and Dierck Hillman from Thorlabs OCT team will detail the system characterizations and variations attributed to both swept-source (SS-OCT) and Spectral-Domain (SD-OCT) technologies. In all optical assemblies, including OCT systems, interrelationships exist among optical parameters. Significant performance parameters for OCT systems include: axial resolution & imaging depth, lateral ...

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      Mentions: Thorlabs

    15. Use of optical coherence tomography and light microscopy for characterisation of mechanical properties and cellular level responses of ‘Centurion’ blueberries during weight loss

      Explore ScienceDirect NDE/NDT , Other Non-Medical
      Use of optical coherence tomography and light microscopy for characterisation of mechanical properties and cellular level responses of ‘Centurion’ blueberries during weight loss

      Postharvest blueberry softening hinders consumer acceptance and correlates with high moisture loss during storage. Such textural variations have been attributed to factors such as turgor, cell wall modifications and other microstructural changes in the outer cell layers of the fruit. This paper investigates the impact of moisture loss on blueberry quality, as well as the structure and/or function relationships associated with fruit mechanical properties during postharvest using an integrated physical and novel microstructural approach. Four different weight loss conditions [62%, 76%, 93% and 98% relative humidity (RH)] at 5.7 °C were evaluated over a three-week postharvest storage period ...

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      Mentions: University of Auckland

    16. Utilization potential of intraluminal optical coherence tomography for the Eustachian tube

      Explore Nature Publishing Group Otolaryngology
      Utilization potential of intraluminal optical coherence tomography for the Eustachian tube

      Imaging the Eustachian tube is challenging because of its complex anatomy and limited accessibility. This study fabricated a fiber-based optical coherence tomography (OCT) catheter and investigated its potential for assessing the Eustachian tube anatomy. A customized OCT system and an imaging catheter, termed the Eustachian OCT, were developed for visualizing the Eustachian tube. Three male swine cadaver heads were used to study OCT image acquisition and for subsequent histologic correlation. The imaging catheter was introduced through the nasopharyngeal opening and reached toward the middle ear. The OCT images were acquired from the superior to the nasopharyngeal opening before and after ...

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      Mentions: Yonsei University Hanyang University

    17. OCT Capillary Depth Measurement in Copper Micro Welding Using Green Lasers

      Explore MDPI Open Access Journals Platform NDE/NDT
      OCT Capillary Depth Measurement in Copper Micro Welding Using Green Lasers

      The transition of the powertrain from combustion to electric systems increases the demand for reliable copper connections. For such applications, laser welding has become a key technology. Due to the complexity of laser welding, especially at micro welding with small weld seam dimensions and short process times, reliable in-line process monitoring has proven to be difficult. By using a green laser with a wavelength of λ = 515 nm, the welding process of copper benefits from an increased absorption, resulting in a shallow and stable deep penetration welding process. This opens up new possibilities for the process monitoring. In this contribution, the ...

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    18. See all articles

  2. Recent Articles From Around The Web

    1. Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device

      Explore Home - Springer Ophthalmology
      Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device

      Purpose: To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device. Methods: A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT (SS-OCT) (Optos PLC; Dunfermline, UK). Scanning laser ophthalmoscope (SLO) images and the associated SS-OCT images were obtained in the posterior pole, mid-periphery or far periphery based on the nature of the referral and on new areas of interest observed in the optomap images at the time of imaging. Results: A total of 134 eyes (96 patients) were enrolled in the study. One hundred and twenty-five eyes ...

      Read Full Article
      Mentions: University of Toronto University of Cambridge Optos

    2. The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      Explore ScienceDirect Neurology , Ophthalmology , Textbooks
      The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      Optical coherence tomography (OCT) is a noninvasive ocular imaging technique that has become a standard tool in neuroophthalmic practice. Specifically, OCT captures retinal manifestations of neuroaxonal injury caused by lesions along anterior and posterior regions of the afferent visual pathway, in patients presenting with vision loss. More recently, the advent of OCT angiography (OCTA) has enabled evaluation of the choroidal and retinal microvasculature, thus informing our understanding regarding vascular mechanisms associated with optic nerve and retinal injuries. Much of our longitudinal experience with OCT in the field of neuroophthalmology has been acquired from the study of optic neuritis (ON) caused ...

      Read Full Article
      Mentions: University of Calgary

    3. 'Y' split of the outer plexiform layer: an optical coherence tomography illusion!

      Explore casereports.bmj.com Ophthalmology
      'Y' split of the outer plexiform layer: an optical coherence tomography illusion!

      We here in report an interesting optical coherence tomography (OCT) observation in two different eyes. First case represents a 26-year-old man, with a history of tobacco chewing for 8 years, presented with sudden onset of scotoma in his right eye for 1 week. The uncorrected visual acuity was 20/40 in right eye (OD) and 20/20 in left eye (OS), respectively. Anterior segment was essentially within normal limits. Right eye fundus examination revealed a dull foveal reflex with neurosensory detachment and subretinal fibrin features suggestive of central serous chorioretinopathy. OCT of OD passing through macula confirmed presence of a ...

      Read Full Article
      Mentions: L V Prasad Eye Institute

    4. Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography

      Explore Home - Springer Ophthalmology
      Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography

      Optical coherence tomography (OCT) is a three-dimensional (3-D) optical imaging technology that provides noninvasive, micrometer resolution images of structural interiors within biological samples with an approximately 1 ~ 2 mm penetration depth. Over the last decades, advances in OCT have revolutionized biomedical imaging by demonstrating a potential of optical biopsy in preclinical and clinical settings. Recently, functional OCT imaging has shown a promise as angiography to visualize cell-perfused vasculatures in the tissue bed in vivo without requiring any exogenous contrast agents. This new technology termed OCT angiography (OCTA) possesses a unique imaging capability of delineating tissue morphology and blood or lymphatic ...

      Read Full Article

    5. Physicians: The future of cardiac imaging is now

      Explore DOTmed.com Cardiology
      Physicians: The future of cardiac imaging is now

      Use of dedicated imaging catheters as an adjunct to conventional angiography (x-ray imaging) can assist in the diagnosis and guide the treatment of narrowing coronary arteries during invasive procedures to treat angina. Optical coherence tomography (OCT) is a red light-based imaging technique that captures high-resolution images when the catheter is placed inside the patient’s heart arteries; the high-quality and granular data thus obtained allows physicians to assess anatomy and execute coronary interventions, such as stent placement, with unrivalled precision. Recent data have indicated that use of OCT can alter physician decision-making over conventional x-ray (angiographic) imaging alone in nearly ...

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    6. Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

      Explore Nature Publishing Group Ophthalmology
      Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography

      To analyze the relationships between the fixation location and the visual function of idiopathic macular hole (IMH) patients with macular integrity assessment (MAIA) examination preoperatively and 3 months postoperatively. This was a retrospective case analysis. Forty-three eyes of 43 patients diagnosed with IMH were included in this study. The best corrected visual acuity (BCVA) assessments, optical coherence tomography (OCT) and MAIA examinations were performed before surgery and 1 week, 1 month and 3 months after surgery. The relationships between MAIA parameters and visual acuity were assessed by correlation analysis. Grouping by fixation location with the foveola (2°) as the centre ...

      Read Full Article
      Mentions: Nankai University

    7. Learning With Fewer Images via Image Clustering: Application to Intravascular OCT Image Segmentation

      Explore IEEE Xplore Cardiology
      Learning With Fewer Images via Image Clustering: Application to Intravascular OCT Image Segmentation

      Deep learning based methods are routinely used to segment various structures of interest in varied medical imaging modalities. Acquiring annotations for a large number of images requires a skilled analyst, and the process is both time consuming and challenging. Our approach to reduce effort is to reduce the number of images needing detailed annotation. For intravascular optical coherence tomography (IVOCT) image pullbacks, we tested 10% to 100% of training images derived from two schemes: equally-spaced image subsampling and deep-learning- based image clustering. The first strategy involves selecting images at equally spaced intervals from the volume, accounting for the high spatial ...

      Read Full Article
      Mentions: Case Western Reserve University

    8. En face image-based classification of diabetic macular edema using swept source optical coherence tomography

      Explore Nature Publishing Group Ophthalmology
      En face image-based classification of diabetic macular edema using swept source optical coherence tomography

      This retrospective study was performed to classify diabetic macular edema (DME) based on the localization and area of the fluid and to investigate the relationship of the classification with visual acuity (VA). The fluid was visualized using en face optical coherence tomography (OCT) images constructed using swept-source OCT. A total of 128 eyes with DME were included. The retina was segmented into: Segment 1, mainly comprising the inner nuclear layer and outer plexiform layer, including Henle's fiber layer; and Segment 2, mainly comprising the outer nuclear layer. DME was classified as: foveal cystoid space at Segment 1 and no ...

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    9. A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery

      Explore Home - Springer Ophthalmology
      A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery

      The introduction of the intraocular vitrectomy instrument by Machemer et al. has led to remarkable advancements in vitreoretinal surgery enabling the limitations of human physiologic capabilities to be reached. To overcome the barriers of perception, tremor, and dexterity, robotic technologies have been investigated with current advancements nearing the feasibility for clinical use. There are four categories of robotic systems that have emerged through the research: (1) handheld instruments with intrinsic robotic assistance, (2) hand-on-hand robotic systems, (3) teleoperated robotic systems, and (4) magnetic guidance robots. This review covers the improvements and the remaining needs for safe, cost-effective clinical deployment of ...

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    10. Evaluation of coronary plaques and atherosclerosis using optical coherence tomography

      Explore Taylor & Francis Online Cardiology
      Evaluation of coronary plaques and atherosclerosis using optical coherence tomography

      Introduction: Coronary angiography (CAG) is the standard modality for assessing coronary stenosis; however, it has limitations in assessing coronary plaque morphology. Optical coherence tomography (OCT) is a high-resolution (10-20μm) light-based intravascular imaging technique that can identify more detailed coronary plaque morphology compared to other intravascular imaging modalities. OCT is remarkable for characterizing fibrous, fibrocalcific, and lipid-rich plaques. The capabilities of OCT are well suited for discriminating three types of unstable plaque morphologies underlying coronary thrombosis, such as plaque rupture, erosion, and calcified nodules. The high resolution of OCT makes it possible to identify important features of vulnerable plaques, such ...

      Read Full Article
      Mentions: Wakayama Medical University

    11. Early coronary healing in ST segment elevation myocardial infarction: sirolimus-eluting stents vs. drug-coated balloons after bare-metal stents. The PEBSI-2 optical coherence tomography randomized study

      Explore LWW Online Cardiology
      Early coronary healing in ST segment elevation myocardial infarction: sirolimus-eluting stents vs. drug-coated balloons after bare-metal stents. The PEBSI-2 optical coherence tomography randomized study

      Objectives: Drug-coated balloons (DCBs) have theoretical advantages over drug-eluting stents (DESs) to facilitate stent healing. We studied whether, in patients undergoing primary coronary interventions (pPCIs), a strategy of DCB after bare-metal stent improves early healing as determined by optical coherence tomography (OCT) compared with new-generation DES. Methods: pPCI patients were randomized (1:1) to treatment with new-generation sirolimus-eluting stents (DES group) or DCB-strategy. Vessel healing was assessed by OCT at 90 days. Results: Fifty-three patients were randomized (26 DES vs. 27 DCB). At 90 days, both strategies showed a low rate of uncovered struts (3.2 vs. 3.2%, P ...

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    13. A Swept source optical coherence tomography angiography study: Imaging artifacts and comparison of non-perfusion areas with fluorescein angiography in diabetic macular edema

      Explore Journals | PLOS Ophthalmology
      A Swept source optical coherence tomography angiography study: Imaging artifacts and comparison of non-perfusion areas with fluorescein angiography in diabetic macular edema

      Purpose Swept Source Optical coherence tomography angiography (SS-OCTA) is a novel technique to visualize perfusion and vascular changes like ischemia in patients with diabetic retinopathy. The aim of this study was to compare non-perfusion areas on conventional fluorescein angiography (FA) with those on SS-OCTA using detailed manual annotation in patients with diabetic macular edema (DME) and to evaluate possible artifacts caused by DME on SS-OCTA. Methods 27 eyes of 21 patients with DME were analyzed in this prospective, cross-sectional study; on all, standard ophthalmological examination, SS-OCTA and FA imaging were performed. Early-phase FA and SS-OCTA images were analyzed for capillary ...

      Read Full Article
      Mentions: Optovue Harvard University Johannes Kepler University of Linz

    14. Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Explore Nature Publishing Group Ophthalmology
      Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

      Purpose To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. Materials and methods A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures ...

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      Mentions: Shanghai Jiao Tong University

    15. Tear evaluation by anterior segment OCT in dry eye disease

      Explore rjo.ro Ophthalmology
      Tear evaluation by anterior segment OCT in dry eye disease

      Objective: Dry Eye Disease (DED) is a multifactorial disorder, centered by loss of tear homeostasis. The diagnosis represents a challenge in the absence of a gold standard, so different questionnaires and techniques are combined. Considering that a low lacrimal secretion and a high rate of evaporation can determine changes in the tear film, the question that arises is if there are differences between the tear film thickness and the tear meniscus values of patients with DED compared to healthy volunteers, and if so, if they can be proposed as an objective diagnosis technique using Optical Coherence Tomography (OCT). Materials and ...

      Read Full Article
      16. See all articles
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  8. Picture Gallery

    Feasibility and Safety of the Novel Vivolight Frequency Domain Optical Coherence Tomography System: A Multicenter Study First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI Postdoctoral Research Fellow position at Legacy Devers Eye Institute – Discoveries in Sight Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid–structure interaction models and machine learning methods with patient follow-up data: a feasibility study Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers 900 Specsavers stores install OCT Advantage of low NEP balanced receivers in swept source OCT OCT applications in optics R&D and manufacturing Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

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    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
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    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu