1. Recent Articles From Around The Web

    1. Efficient supercontinuum generation enabled by dispersion engineering in a dual-core waveguide

      Efficient supercontinuum generation enabled by dispersion engineering in a dual-core waveguide

      A compact dual-core waveguide is proposed for efficient supercontinuum generation, in which the use of Si-rich nitride and titanium dioxide provides a large enough index contrast for dispersion engineering. Strong anomalous group velocity dispersion is obtained over a wide bandwidth of 1860 nm which greatly reduces the dispersion length. The nonlinear length can also be significantly decreased due to high nonlinear Kerr index of Si-rich nitride. As a consequence, it could facilitate octave-spanning supercontinuum generation from 1160 to 2385 nm in a greatly reduced propagation distance, as short as 165μm . It is more than one order of magnitude shorter ...

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    2. 3D Fingerprint Gender Classification Using Deep Learning

      3D Fingerprint Gender Classification Using Deep Learning

      Optical Coherence Tomography (OCT) is a high resolution imaging technology, which provides a 3D representation of the fingertip skin. This paper for the first time investigates gender classification using those 3D fingerprints. Different with current fingerprint gender classification methods, the raw multiple longitudinal( X - Z ) fingertip images of one finger can be applied instead of studying features extracted from fingerprints, and the model can be trained effectively when the training data set is relatively small. Experimental results show that the best accuracy of 80.7% is achieved by classifying left fore finger on a small database with 59 persons. Meanwhile ...

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    3. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Purpose: To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy (DR). Methods: A deep learning convolutional neural network (CNN) architecture VGG16 was employed for this study. A transfer learning process was implemented to re-train the CNN for robust OCTA classification. In order to demonstrate the feasibility of using this method for artificial intelligence (AI) screening of DR in clinical environments, the re-trained CNN was incorporated into a custom developed GUI platform which can be readily operated by ophthalmic personnel. Results: With last nine layers re-trained, CNN architecture achieved the best performance ...

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      Mentions: Xincheng Yao
    4. Imaging in Neuro-ophthalmology

      Imaging in Neuro-ophthalmology

      PURPOSE OF REVIEW:This article discusses an approach to imaging in patients with neuro-ophthalmologic disorders, with emphasis on the clinical-anatomic localization of lesions affecting afferent and efferent visual function. RECENT FINDINGS:Advances in MRI, CT, ultrasound, and optical coherence tomography have changed how neuro-ophthalmic disorders are diagnosed and followed in the modern clinical era. SUMMARY:The advantages, disadvantages, and indications for various imaging techniques for neuro-ophthalmologic disorders are discussed, with a view to optimizing how these tools can be used to enhance patient care.

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    5. Precision Microfabrication of Optical Probes for Intravascular Diagnostics (Thesis)

      Precision Microfabrication of Optical Probes for Intravascular Diagnostics (Thesis)

      This thesis details a collection of design, optimisation, fabrication and characterisation work to form fiber-optic probes and optical phantom devices for intravascular diagnostics in minimally invasive surgery (MIS). Optically generated ultrasound is an emerging technique to create broadband high frequency ultrasound via the photoacoustic effect. In the first segment of this thesis, the development of a novel miniature fiber-optic ultrasound transmitter is detailed. A morphologically controlled coating was formed at the endface of a multimode optical fiber by controlled electrospinning of a carbon-nanotube composite. Efficient optical ultrasound generation was realised, with signal amplitude, bandwidth and device form factor suited to ...

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    6. Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

      Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

      The purpose of this study was to measure central macular thickness in an unprecedented number of cynomolgus monkeys. Macular thickness was measured with Heidelberg spectral-domain OCT in 320 eyes of healthy and treatment-naïve cynomolgus monkeys (80 males and 80 females). The macula was successfully measured in all 320 eyes. Macular thickness was not significantly different between the sexes. The mean central macular thickness was 244 μm (+/- 21 μm). Macular thicknesses in the quadrants were 327 +/-17 μm (temporal inner), 339 +/- 17 μm (inferior inner), 341 +/- 14 μm (superior inner), 341 +/-18 μm (nasal inner), and 299 +/- 20 μm (temporal ...

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    7. Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation

      Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation

      Evidence regarding the role of early (<24 hours) antithrombotics post-revascularization with either intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), or a combination of both remains scarce. In 2018 the American Heart Association/American Stroke Association changed their recommendation, stating that the risk of antithrombotic therapy within the first 24 hours after treatment with IVT (with or without EVT) is uncertain. This was changed after data emerged that early antithrombotics may be safe and may improve outcomes in select patients undergoing EVT. Recently our group showed for the first time that significant residual basilar thrombus can exist after EVT despite complete angiographic ...

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    8. Assessment of Anterior Chamber by Ultrasound Biomicroscopy and Anterior Segment Optical Coherence Tomography in Patients with Inflammatory Glaucoma

      Assessment of Anterior Chamber by Ultrasound Biomicroscopy and Anterior Segment Optical Coherence Tomography in Patients with Inflammatory Glaucoma

      Objective To investigate the clinical indications of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) in eyes with inflammatory glaucoma. Methods Sixteen patients (16 eyes) with inflammatory glaucoma were analysed retrospectively. All of the subjects underwent UBM and AS-OCT scans, measuring the following parameters: central corneal thickness (CCT), central anterior chamber depth (ACD), angle-opening distance (AOD500), and trabecular-iris angle (TIA500) in four quadrants. Results Both the UBM and AS-OCT generated detailed, high-resolution images of the anterior segments of the eyes with inflammatory glaucoma. Moreover, the UBM and AS-OCT exhibited statistically similar measurement results for all of the indices ...

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    9. Double Interferometer Design for Independent Wavefront Manipulation in Spectral Domain Optical Coherence Tomography

      Double Interferometer Design for Independent Wavefront Manipulation in Spectral Domain Optical Coherence Tomography

      Spectral domain optical coherence tomography (SD-OCT) is a highly versatile method which allows for three dimensional optical imaging in scattering media. A number of recent publications demonstrated the technique to benefit from structured illumination and beam shaping approaches, e.g. to enhance the signal-to-noise ratio or the penetration depth with samples such as biological tissue. We present a compact and easy to implement design for independent wavefront manipulation and beam shaping at the reference and sample arm of the interferometric OCT device. The design requires a single spatial light modulator and can be integrated to existing free space SD-OCT systems ...

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    10. Avinger, Inc.: Avinger Expands US Reach with Seven New Accounts in Third Quarter

      Avinger, Inc.: Avinger Expands US Reach with Seven New Accounts in Third Quarter

      Avinger, Inc. (NASDAQ:AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the launch of seven new Lumivascular centers during the third quarter, including sites in the high-volume PAD markets of Florida, Georgia and Arizona. This growth in new accounts is the result of continued expansion of Avinger's sales team and strong market demand for the Company's Pantheris and Pantheris SV image-guided atherectomy products. "We are excited to report the launch of seven new clinical centers using Avinger's best-in-class Lumivascular ...

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      Mentions: Avinger
    11. Short-term variations of optic coherence tomography findings in mild and severe chronic obstructive pulmonary disease

      Short-term variations of optic coherence tomography findings in mild and severe chronic obstructive pulmonary disease

      Objective To evaluate the short-term changes in subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) analysis, and retinal nerve fiber length (RNFL) of patients with chronic obstructive pulmonary disease (COPD) in a 3-month follow-up. Materials and methods Forty-eight patients with COPD (96 eyes) and 40 control subjects (80 eyes) were enrolled in our study. COPD patients were grouped according to disease severity as Group 1 (mild–moderate) and Group 2 (advanced). GCC, RNFL, and SFCT analysis by Cirrus SD-OCT were obtained for all eyes, in two consecutive examinations with a 3-month interval. Results SFCT in Group 2 was lower than ...

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    12. Dual-angle optical coherence tomography for index of refraction estimation using rigid registration and cross-correlation

      Dual-angle optical coherence tomography for index of refraction estimation using rigid registration and cross-correlation

      The index of refraction ( n ) of materials and/or tissues depends on their physical properties and serves as a source of optical contrast in imaging. The variations of the index of refraction have also been investigated for diagnostic purposes in various fields, such as hematology, oncology, etc., since they can signify disease and cell dynamic changes. Optical coherence tomography (OCT) has been used in the past to measure the index ex vivo . However, most methodologies described in the literature are not appropriate for in vivo imaging since they require either a mirror below the sample or a complicated imaging setup ...

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    13. Machine learning of retinal pathology in optical coherence tomography images

      Machine learning of retinal pathology in optical coherence tomography images

      Background: Acute macular degeneration (AMD), central serous retinopathy (CSR), diabetic retinopathy (DR) and macular hole (MH) are common vision impairing pathologies in the field of ophthalmology. Machine learning with deep convolutional neural networks can be used to analyze ophthalmological diseases using fundus and optical coherence tomography (OCT) images, but with limited accuracy. In order to improve the sensitivity and specificity of these models, the objective of this study was to examine the effect of data augmentation on the performance of the neural network. Methods: OCT Images for above pathologies and normal eye were acquired from the Optical Coherence Tomography Image ...

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    14. Resolution enhancement in low transverse sampling optical coherence tomography angiography using deep learning

      Resolution enhancement in low transverse sampling optical coherence tomography angiography using deep learning

      Optical coherence tomography angiography (OCTA) requires high transverse sampling rates for visualizing retinal and choroidal capillaries, which impedes the popularization of the OCTA technique due to the high cost of speedy acquisition systems. On the other hand, current wide-field OCTA using low transverse sampling causes the underestimation of vascular biomarkers in quantitative analysis. In this paper, we propose to use deep learning to repair the resolution degeneration induced by the low transverse sampling. We conducted preliminary experiments on converting the centrally cropped 3 × 3 mm2 field of view (FOV) of the 8 × 8 mm2 foveal OCTA images (a sampling rate ...

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    15. Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

      Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

      Purpose : To evaluate the prognostic value of OCT in acute VKH disease Methods : Retrospective series of consecutive VKH patients seen with the first presentation, a minimum follow-up of 1 year and serial OCT imaging. The primary outcome was the clinical activity phase at 1, 2 and 3 years. Results : Among 29 subjects, 7 resolved, 17 became chronic, and 5 developed chronic recurrent VKH. Median RNFL measurement obtained 2 months post-treatment was higher among subjects who developed chronic VKH ( p -value = 0.03) and chronic recurrent disease ( p -value = 0.04). Median CRT 1-week post-treatment was lower among subjects who developed ...

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    Metasurface-based focus-tunable mirror Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for  Optical Coherence Tomography” Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery Advances In Intraoperative OCT Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging OCT-Based Tooth Scan and Reconstruction Intravascular optical coherence tomography method for automated detection of macrophage infiltration within atherosclerotic coronary plaques
  6. Recent Quotes

    1. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    2. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    3. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    4. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    5. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    6. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    7. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    8. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    9. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    10. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney