1. Feature Of The Week: University of Washington Demonstrates In vivo Microvascular Imaging of Human Oral and Nasal Cavities using SS-OCT

    Over decades, optical coherence tomography (OCT) has proven useful in the diagnosis of cavity disorders through in vivo feasibility or clinical studies in human. OCT studies have evaluated changes in cavity tissue morphology and optical properties of backscattered OCT signals from cavity tissue layers for the identification of abnormalities. Notwithstanding, there has been limited discussion regarding the assessment of microvasculature in human cavity tissues. The microcirculation within cavity tissues would be an invaluable indicator for assessing cavity disorders due to vascular malformation associated with disease progression.

    In this work, we report three-dimensional (3D) imaging of microcirculation within human cavity tissues in vivo using a high-speed swept-source optical coherence tomography (SS-OCT) at 1.3 µm with a modified probe interface. Volumetric structural OCT images of the inner tissues of oral and nasal cavities are acquired with a field of view of 2 mm × 2 mm. Two types of disposable and detachable probe attachments are devised and applied to the port of the imaging probe of OCT system, enabling forward and side imaging scans for selective and easy access to specific cavity tissue sites. Blood perfusion is mapped with OCT-based microangiography from 3D structural OCT images, in which a novel vessel extraction algorithm is used to decouple dynamic light scattering signals, due to moving blood cells, from the background scattering signals due to static tissue elements. Characteristic tissue anatomy and microvessel architectures of various cavity tissue regions of a healthy human volunteer are identified with the 3D OCT images and the corresponding 3D vascular perfusion maps at a level approaching capillary resolution. The initial finding suggests that the proposed method may be engineered into a promising tool for evaluating and monitoring tissue microcirculation and its alteration within a wide-range of cavity tissues in the patients with various pathological conditions.

    Courtesy of Woo June Choi and Ruikang Wang from University of Washington. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Columbia University Receives NIH Grant for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration

      Columbia University Receives NIH Grant for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration

      Columbia University Receives a 2015 NIH Grant for $281,840 for Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration. The principal investigator is Ronald Silverman. The program began in 2012 and ends in 2016. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is a disease of the retinal pigment epithelium characterized by the appearance of protein/lipid deposits (drusen), geographic atrophy and neovascularization. Techniques currently used for diagnostic imaging of AMD include indocyanine green dye or fluorescein angiography, autofluorescence imaging and optical coherence tomography (OCT). OCT images depict optical backscatter, caused by variation in ...

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    2. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), especial swept-source OCT, is preferred. Good publication record and communication skills. Strong programming skills (Matlab, Labview, C++ and GPU programming) are pluses. Research areas: The ...

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    3. Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery

      Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery

      The purpose was to compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue OCT) for ganglion cell complex (GCC) and retinal nerve fibre layer thickness (RNFLT) changes after phacoemulsification in healthy cataract eyes, and to investigate whether version 6.12, in which image segmentation is improved, provides benefits over version 6.3 for RNFLT and GCC imaging via mild cataract. One eye of 22 consecutive healthy cataract patients were imaged before and 1 month after uncomplicated cataract surgery using RTVue-100 OCT software version 6.3. The images were analysed with ...

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      Enhancing the visualization of human retina vascular networks by Graphics Processing Unit accelerated speckle variance OCT and graph cut retinal layer segmentation

      We present a Graph Cut based image segmentation that was implemented on a Graphics Processing Unit for acceleration of processing retinal images acquired with OCT. We applied this work to generate a retinal thickness map, and for retinal layer segmentation to enhance the visualization of vasculature networks from distinct retinal capillary beds during acquisition using speckle variance OCT.

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    5. Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography

      Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography

      In spectral-domain optical coherence tomography (SD-OCT), the limited resolution of the spectrometer causes nonuniformity of the interference signal. The latter, in turn, causes the sensitivity of SD-OCT to decrease, thereby limiting the imaging range and decreasing the axial resolution. We addressed this problem by applying nonuniform, nonharmonic analysis (NUNHA) with software that features high-frequency resolution without interpolation. We demonstrate the application of NUNHA in SD-OCT and compare it with conventional frequency analysis methods by simulating nonuniform interference signals. The results suggest that application of NUNHA in SD-OCT can provide acquisition of a clearer tomographic image, accurate analysis of fine and ...

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    6. Modeling and Simulation of Optical Coherence Tomography on Virtual OCT

      Modeling and Simulation of Optical Coherence Tomography on Virtual OCT

      Optical Coherence Tomography (OCT) is noninvasive emerging medical imaging technique for acquiring depth resolved information from human tissues. Some of the commercially available OCT systems have found their applications in ophthalmology, where one can acquire detailed images from within the retina. Recently OCT has found its applications in blood flow estimation, cancer diagnosis, dermatology, dentistry, gastroenterology and other non-biomedical applications. For this purpose simulation of OCT has been done using Lab VIEW and Matlab scripts. Spectral domain OCT (SD-OCT) which is recent modification to traditional time domain OCT systems and has advantage of faster signal acquisition rates and higher signal ...

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    7. Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome

      Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome

      Purpose To investigate the choroidal thickness using optical coherence tomography in the eyes of patients with unilateral and bilateral pseudoexfoliation syndrome and to compare them with healthy controls. Methods We studied four groups: (1) affected eyes from 30 patients with unilateral PEX syndrome affecting the right eye of 17 patients and the left eye of 13 patients; (2) clinically unaffected eyes of 30 patients with unilateral PEX syndrome; (3) the eyes of 30 patients with bilateral PEX syndrome; and (4) the eyes of 30 normal healthy subjects. Choroidal thickness was evaluated using high-speed, high-resolution enhanced depth imaging by spectral-domain optical ...

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      Anterior segment optical coherence tomography (AS-OCT) was recently developed and has become a crucial tool in clinical practice. AS-OCT is a noncontact imaging device that provides the detailed structure of the anterior part of the eyes. In this review, the author will discuss the various clinical applications of AS-OCT, such as the normal findings, tear meniscus measurement, ocular surface disease (e.g., pterygium, pinguecula, and scleromalacia), architectural analysis after cataract surgery, post-LASIK keratectasia, Descemet’s membrane detachment, evaluation of corneal graft after keratoplasty, corneal deposits (corneal dystrophies and corneal verticillata), keratitis, anterior segment tumors, and glaucoma evaluation (angle assessment, morphological ...

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      Slow-Flow Phenomenon After Paclitaxel-Coated Balloon Angioplasty: Findings From Optical Coherence Tomography and Coronary Angioscopy

      In case 1, a 60-year-old man underwent a 4.0-mm × 12-mm bare-metal stent (BMS) implantation in the proximal left anterior descending coronary artery. Six months after BMS implantation, a coronary angiogram demonstrated in-stent restenosis (ISR) at the proximal portion of the stent (Figure 1 ). Frequency-domain optical coherence tomography (FD-OCT) revealed homogeneous neointima (Figure 1 ) and coronary angioscopy (CAS) revealed white neointimal coverage at the ISR site (Figure 1 ). The lesion was dilated using a 3.5 × 13-mm conventional balloon catheter at 16 atm. After balloon angioplasty, Thrombolysis In Myocardial Infarction (TIMI) flow grade 3 was achieved, and intracoronary electrocardiography did ...

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      Spectral domain optical coherence tomography imaging of tubercular chorioretinitis and intraretinal granuloma. Intraretinal tuberculosis: a case report

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      Background : Fibromuscular dysplasia (FMD) is a non-inflammatory, non-atherosclerotic, degenerative vascular disease that most frequently affects renal and carotid arteries in women aged 30–50 years, and rarely complicating arteries of the lower limbs. Case Report : A 60-year-old woman was admitted with intermittent claudication of both legs. We performed pelvic and bilateral lower-extremities angiography, which revealed that the bilateral external iliac arteries (EIAs) had the ‘string of beads’ appearance with a diagnosis of FMD. Endovascular therapy (EVT) was performed for the bilateral EIAs. Optical coherence tomography (OCT) images showed thickening and thinning of the middle layer, while three-dimensional OCT images showed ...

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      The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration

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      Molecular Imaging in Optical Coherence Tomography

      Optical coherence tomography (OCT) is a medical imaging technique that provides tomographic images at micron scales in three dimensions and high speeds. The addition of molecular contrast to the available morphological image holds great promise for extending OCT’s impact in clinical practice and beyond. Fundamental limitations prevent OCT from directly taking advantage of powerful molecular processes such as fluorescence emission and incoherent Raman scattering. A wide range of approaches is being researched to provide molecular contrast to OCT. Here we review those approaches with particular attention to those that derive their molecular contrast directly from modulation of the OCT ...

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      Neointimal hyperplasia, the major cause of arteriovenous graft (AVG) stenosis, is not directly visualized by angiography. A 60-year-old woman on hemodialysis presented with a clotted AVG 30 days after its creation. Following percutaneous thrombectomy, angiography revealed severe (> 50%) stenosis at the graft (G)-vein (V) anastomosis (arrow in Fig 1 ). Optical coherence tomography performed using an intravascular Dragonfly catheter (St. Jude Medical, Westford, Massachusetts) delineated the intima in bright yellow.

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    15. Multimodal Imaging In Foveal Red Spot Syndrome

      Multimodal Imaging In Foveal Red Spot Syndrome

      Purpose: To describe multimodal imaging findings in a patient with foveal red spot syndrome. Methods: We report a case of a 57-year-old man with foveal red spot syndrome. Multimodal imaging techniques, including fundus color and red-free photographs, fluorescence angiography (Topcon 50DX; Topcon, Tokyo, Japan), MultiColor scanning laser imaging, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), swept source optical coherence tomography (DRI OCT-1 Atlantis; Topcon, Tokyo, Japan), adaptive optics (RTX-1; Imagine Eyes, Orsay, France), and microperimetry (MP1 Microperimeter; Nidek Technologies, Padua, Italy), were performed to confirm the diagnosis and determine the anatomical abnormalities related to the disease. Results ...

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    16. See all articles
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    Cadaveric in-situ testing of optical coherence tomography system-based skull base surgery guidance Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy Near video-rate optical coherence elastography by acceleration with a graphics processing unit Measuring the optical characteristics of medulloblastoma with optical coherence tomography Quantitative microvascular hemoglobin mapping using visible light spectroscopic Optical Coherence Tomography Imaging of retinal vasculature using adaptive optics SLO/OCT Fujimoto receives the OSA Frederic Ives Medal Vertically Integrated Array-type Mirau-based Oct System for early detection of skin pathologies Ex vivo catheter-based imaging of coronary atherosclerosis using multimodality OCT and NIRAF excited at 633 nm New techniques of intravessel imaging in coronary atherosclerosis High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch Imaging of spectral-domain optical coherence tomography using a superluminescent diode based on InAsquantum dots emitting broadband spectrum with Gaussian-like shape
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