1. Feature Of The Week: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival

    Objectives
    This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI).

    Background
    Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints.

    Methods
    This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 patients in the study. The primary endpoint was all-cause mortality at a median of 4.8 years.

    Results
    OCT was used in 1,149 (1.3%) patients, intravascular ultrasound (IVUS) was used in 10,971 (12.6%) patients, and angiography alone in the remaining 75,046 patients. Overall OCT rates increased over time (p < 0.0001), with variation in rates between centers (p = 0.002). The mean stent length was shortest in the angiography-guided group, longer in the IVUS-guided group, and longest in the OCT-guided group. OCT-guided procedures were associated with greater procedural success rates and reduced in-hospital MACE rates. A significant difference in mortality was observed between patients who underwent OCT-guided PCI (7.7%) compared with patients who underwent either IVUS-guided (12.2%) or angiography-guided (15.7%; p < 0.0001) PCI, with differences seen for both elective (p < 0.0001) and acute coronary syndrome subgroups (p = 0.0024). Overall this difference persisted after multivariate Cox analysis (hazard ratio [HR]: 0.48; 95% confidence interval [CI]: 0.26 to 0.81; p = 0.001) and propensity matching (hazard ratio: 0.39; 95% CI: 0.21 to 0.77; p = 0.0008; OCT vs. angiography-alone cohort), with no difference in matched OCT and IVUS cohorts (HR: 0.88; 95% CI: 0.61 to 1.38; p = 0.43).

    Conclusions
    In this large observational study, OCT-guided PCI was associated with improved procedural outcomes, in-hospital events, and long-term survival compared with standard angiography-guided PCI.

    For more information see recent Article. Courtesy Daniel Jones from Barts and The London School of Medicine and Dentistry. To share this article click Here.

  2. Featured Articles

    1. Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      Explore OSA | OSA Publishing Tunable Sources
      Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to ...

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      Mentions: Robert A. Huber University of Lübeck Technical University of Munich

    2. Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Explore OSA | OSA Publishing Dentistry
      Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Early detection of dental caries is known to be the key to the effectiveness of therapeutic and preventive approaches in dentistry. However, existing clinical detection techniques, such as radiographs, are not sufficiently sensitive to detect and monitor the progression of caries at early stages. As such, in recent years, several optics-based imaging modalities have been proposed for the early detection of caries. The majority of these techniques rely on the enhancement of light scattering in early carious lesions, while a few of them are based on the enhancement of light absorption at early caries sites. In this paper, we report ...

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    3. Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Explore Optical Coherence Tomography News Jobs & Studentships
      Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Job Description This opening is for a senior mechanical engineer who will be responsible for the design and development and manufacturing of several intravascular catheters and pullback devices used in intravascular imaging. Senior mechanical engineer will develop disposable devices following FDA regulatory standards, by working in coordination with regulatory professionals, optical engineers and software professionals in the company. Moreover, senior mechanical engineer will, maintain history files of product designs, and make changes by working in close coordination with end-users as needed. This position requires a bachelor’s degree in mechanical engineering with 10 years’ experience in medical device industry or ...

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      Mentions: FDA OCT Medical Imaging Inc

    4. Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Now available is a position for a Postdoc in Biomedical Optics, Biophotonics, Photonics or Optical Microscopy | Ref: 502043 | SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY Two year appointment Salary range: Level A $68,452 – $97,497 p.a. or Level B $97,310 – $115,350 p.a. (dependent on qualifications and experience) Postdoc in Biomedical Optics/Biophotonics/Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top 100 universities in the world and a member of the prestigious Australian Group of Eight research-intensive universities. With an enviable research track record, vibrant campus ...

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      Mentions: David D. Sampson University of Western Australia

    5. Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      Explore MDPI Open Access Journals Platform NDE/NDT
      Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      The non-destructive classification of plant materials using optical inspection techniques has been gaining much recent attention in the field of agriculture research. Among them, a near-infrared (NIR) imaging method called optical coherence tomography (OCT) has become a well-known agricultural inspection tool since the last decade. Here we investigated the non-destructive identification capability of OCT to classify diversely stained (with various staining agents) Capsicum annuum seed specimens of different cultivars. A swept source (SS-OCT) system with a spectral band of 1310 nm was used to image unstained control C. annuum seeds along with diversely stained Capsicum seeds, belonging to different cultivar ...

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      Mentions: Medical University of Vienna Jeehyun Kim Kyungpook National University

    6. Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Explore bioRxiv.org NDE/NDT
      Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Coral reefs are highly productive photosynthetic systems and coral optics studies suggest that such high efficiency is due to optimised light scattering by coral tissue and skeleton. Here, we characterise the inherent optical properties, i.e., the scattering coefficient, μ s , and the anisotropy of scattering, g , of 8 intact coral species using optical coherence tomography (OCT). Specifically, we describe light scattering by coral skeletons, coenoarc tissues, polyp tentacles and areas covered by fluorescent pigments (FP). Our results reveal that light scattering between coral species ranges from μ s = 3 mm -1 ( Stylophora pistillata ) to μ s = 25 mm -1 ( Echinopora lamelosa ). For ...

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      Mentions: Steven L. Jacques Daniel Wangpraseurt Michael Kühl

    7. Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Explore OSA | OSA Publishing
      Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Multiple scattering in turbid media inhibits optimal light focusing and thus limits the penetration depth in optical coherence tomography (OCT). However, the effects of multiple scattering in a turbid medium can be systematically controlled by shaping the incident wavefront. The authors utilize the reciprocity of Maxwell’s equations and finite-difference time-domain numerical analysis to investigate the ultimate performance bounds of wavefront shaping-OCT under ideal and realistic configurations and compare them with the conventional method. The results reveal that the optimized impinging wavefront significantly enhances the penetration depth of OCT.

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      Mentions: Konyang University Korea Advanced Institute of Science and Technology YongKeun Park

    8. Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Explore IEEE Xplore Ophthalmology
      Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Ophthalmic microsurgery is known to be a challenging operation, which requires very precise and dexterous manipulation. Image guided robot-assisted surgery (RAS) is a promising solution that brings significant improvements in outcomes and reduces the physical limitations of human surgeons. However, this technology must be further developed before it can be routinely used in clinics. One of the problems is the lack of proper calibration between the robotic manipulator and appropriate imaging device. In this work, we developed a flexible framework for hand-eye calibration of an ophthalmic robot with a microscope-integrated Optical Coherence Tomography (MI-OCT) without any markers. The proposed method ...

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      Mentions: Carl Zeiss Meditec Technical University of Munich

    9. Axsun Technologies Announces Breakthrough Tunable VCSEL Platform for Optical Coherence Tomography (OCT) Imaging

      Explore Optical Coherence Tomography News Other Business News , Tunable Sources
      Axsun Technologies Announces Breakthrough Tunable VCSEL Platform for Optical Coherence Tomography (OCT) Imaging

      Axsun Technologies, Inc., a leading developer and supplier of MEMSbased optical engines for medical imaging, industrial spectroscopy, and optical telecommunications, today announced the development of a novel Tunable Vertical Cavity Surface Emitting Laser (Tunable VCSEL) platform for OCT imaging applications. Raising the bar on OCT imaging performance, Axsun’s new Tunable VCSEL platform leverages the company’s core strengths of high performance optical integration and cost-effective volume manufacturing. By integrating all the major tunable VCSEL components into a single compact butterfly package, the Axsun tunable VCSEL enables higher performance and flexibility, reliability and scalability with low power consumption. “While our ...

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      Mentions: Axsun Technologies

    10. Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Explore Wiley Online Library Cardiology
      Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Background Intravascular imaging with intravascular ultrasound (IVUS) and optical coherence tomography (OCT) is an important adjunct to invasive coronary angiography. Objectives The primary objective was to examine the frequency of intravascular coronary imaging, trends in imaging use, and outcomes of patients undergoing angiography and/or percutaneous coronary intervention (PCI) in the United States. Methods Adult patients ≥18 years of age undergoing in‐hospital cardiac catheterization from January 2004 to December 2014 were identified from the National Inpatient Sample (NIS). International Classification of Diseases, Ninth Revision (ICD‐9) diagnosis and procedure codes were used to identify IVUS and OCT use during ...

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    11. Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Explore Optical Coherence Tomography News Other Business News
      Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Thorlabs announced today that it has expanded its well-established Ganymede™ OCT line to include two complete imaging systems offering an industry-leading A-scan rate of 248 kHz. With this new release, the GAN610C1 and GAN620C1 become the fastest commercially available Spectral-Domain OCT systems on the market, providing a new standard for high-speed, high-sensitivity 2D and 3D imaging of moving samples with reduced motion artifacts. As with Thorlabs’ previously released Ganymede™ and Telesto™ OCT systems, these new OCT systems are available in both general-purpose (GAN610) and high-resolution (GAN620 – 3 µm axial resolution) variants, each of which offers the same low roll-off and ...

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      Mentions: Thorlabs Michael Leitner

    12. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Explore OSA | OSA Publishing Probes
      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin surface to the epidural space. 847 in vivo optical coherence tomography images were obtained from three anesthetized piglets. The area under the receiver operating characteristic curve was used to quantify ...

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      Mentions: Wen-Chuan Kuo National Yang-Ming University

    13. Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Explore ScienceDirect Cardiology
      Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints . Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 ...

      Read Full Article
      Mentions: Imperial College London Royal Brompton Hospital Christos V. Bourantas

    14. Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Explore ScienceDirect Cardiology
      Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Editorial Comment: In the last 3 decades, intravascular ultrasound (IVUS) and, more recently, optical coherence tomography (OCT) have been increasingly used to guide percutaneous coronary intervention (PCI). Although there are randomized trials, registries, and meta-analyses suggesting better outcomes using IVUS to guide PCI (1–3), data on the clinical impact of OCT are still missing. In the United Kingdom, consecutive data of all PCI procedures must be prospectively entered in the registry organized by the British Cardiovascular Interventional Society, endorsed by the United Kingdom Department of Health, with tracking of events based on the complete and unquestionable national statistics. One ...

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      Mentions: Carlo Di Mario
    15. See all articles

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    2. New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy

      Explore interventions.onlinejacc.org Cardiology
      New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy

      Download figure Open in new tab Download powerpoint Abstract Objectives This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). Background The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis of selected single cross-sections for several decades. The introduction of OCT with its ability to perform semiautomated volumetric analysis opens opportunities to redefine optimal stent expansion. Methods A total of 291 lesions treated with post-stent OCT and ...

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      Mentions: Case Western Reserve University Cardiovascular Research Foundation David Holmes

    3. In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography

      Purposes : To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods : Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian group) were included in this comparative cross-sectional study. The central cornea and the superior, inferior, nasal, and temporal limbal regions of each subject underwent Fourier-domain AS-OCT. The following parameters were measured: corneal epithelial thickness (CET), maximum limbal epithelial thickness (LET), the mean LET, the width of limbus, distance between scleral spur and the location where limbal ...

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      Mentions: Fudan University UCLA

    4. Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy

      Explore Eye and Vision
      Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy

      Background There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA’s imaging capabilities. Methods Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns. OCT signal strengths at the superficial retina, deep retina, Sattler’s layer and ...

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      Mentions: University of Washington Ruikang K. Wang

    5. FRACTAL DIMENSION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF THE CENTRAL MACULA AFTER REPAIR OF RHEGMATOGENOUS RETINAL DETACHMENTS

      Explore LWW Online Ophthalmology
      FRACTAL DIMENSION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF THE CENTRAL MACULA AFTER REPAIR OF RHEGMATOGENOUS RETINAL DETACHMENTS

      Purpose: Patients with macula-off rhegmatogenous retinal detachments (RRDs) may have suboptimal visual recovery, despite successful reattachment due to various reasons. This study was performed to evaluate the retinal microvasculature in subjects undergoing surgery for RRD using optical coherence tomography angiography . Methods: In this case–control study, the analysis of optical coherence tomography angiography findings of 19 eyes of 19 patients (15 men) who underwent RRD surgery at a tertiary institute were compared with 19 eyes of 19 age- and sex-matched healthy subjects with no known ocular disease. 3 × 3-mm optical coherence tomography angiography scans were obtained at 3 months postoperatively ...

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      Mentions: Vishali Gupta

    6. Application of Optical Coherence Tomography Angiography to Retinal Disease

      Explore Hindawi Publishing Corporation Ophthalmology
      Application of Optical Coherence Tomography Angiography to Retinal Disease

      A little over two years ago, a hot new topic in retinal imaging caught the attention of ophthalmologists around the world. Optical coherence tomography angiography (OCTA), an innovative, fast, noninvasive, non-dye-based angiographic technique, quickly became a topic of great interest in major conferences and ophthalmology journals. Inquisitive minds applied the OCTA prototypes to understanding diseases such as macular degeneration, diabetic retinopathy, and glaucoma. The technology’s high resolution and ability to segment the different vascular layers provided novel insight into disease pathogenesis and morphology, providing a unique opportunity to investigate the ocular microvasculature in a level of anatomic detail that ...

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      Mentions: Tufts University University of Miami Nadia K. Waheed

    7. MACULAR VORTEX VEIN IN A HIGHLY MYOPIC EYE IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online
      MACULAR VORTEX VEIN IN A HIGHLY MYOPIC EYE IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To report a case of macular vortex vein imaged with indocyanine green angiography, spectral domain optical coherence tomography, and optical coherence tomography angiography . Methods: Observational case report. Results: A 51-year-old myopic man presented with the complaint of a floater in his left eye for the previous 2 weeks. His visual acuity was 20/25 in the right eye and 20/40 in the left eye. Biomicroscopy was normal. Retinoscopy revealed lattice degeneration and posterior vitreous detachment of both eyes with dilated submacular vasculature in the right eye and submacular hemorrhage in the left eye. Spectral domain optical coherence tomography ...

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      Mentions: New York Eye and Ear Infirmary Richard B. Rosen

    8. Effect of a Basic Skin Care Product on the Structural Strength of the Skin

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Effect of a Basic Skin Care Product on the Structural Strength of the Skin

      The process of aging involves numerous structural and functional changes also affecting the skin. The skin fulfills a variety of protective and regulatory functions. Compared to other organs, the skin is constantly exposed to harmful environmental influences. Besides intrinsic factors these external factors may accelerate skin aging. Due to its ageing-related loss of functional capacity the skin becomes susceptible to develop adverse skin conditions and dermatological diseases (e.g. skin dryness, fungal infections). Especially old aged, care depended, and severely ill individuals are at high risk for developing severe skin injuries and wounds (e.g. decubitus, skin tears) with high ...

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    9. Optical Coherence Tomography-guided Coronary Intervention and Optimal Use of Dual Anti-Platelet Therapy In Patients With Complex Lesions (OCCUPI Trial)

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Optical Coherence Tomography-guided Coronary Intervention and Optimal Use of Dual Anti-Platelet Therapy In Patients With Complex Lesions (OCCUPI Trial)

      There is no definite conclusive work about optimal duration of DAPT after PCI of complex lesions, which have been left at each operator's discretion. It is needed to be investigated how optimal duration of dual antiplatelet therapy will be decided in complex lesions. Also, the benefit of OCT-guided PCI assuming better stent optimization should be determined in complex PCI. In the study, we will explore the clinical implication of OCT-guided PCI of complex lesions. Optimal duration of DAPT after PCI of complex lesions with or without OCT-guidance will be also investigated.

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      Mentions: Yonsei University Yangsoo Jang

    10. Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Explore American Journal of Ophthalmology Ophthalmology
      Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Purpose To investigate conjunctival and intrascleral vasculatures using anterior-segment (AS) optical coherence tomography angiography (OCTA) in normal eyes. Design Cross-sectional study. Methods AS-OCTA images of the corneal limbus were acquired circumferentially using a swept-source OCT system in 10 eyes of 10 healthy subjects. AS-OCTA flow patterns with en face maximum projection were compared between the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The OCTA images were also compared with fluorescein scleral angiography and indocyanine green aqueous angiography images. Quantitative parameters (vessel density, vessel length ...

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      Mentions: UCSD Robert N. Weinreb Akitaka Tsujikawa

    11. Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Explore American Journal of Ophthalmology Ophthalmology
      Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Purpose To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. Design Case-control study. Settings Clinical Practice. Study Population Thirty patients and thirty age-matched controls. Observation Procedures Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan). The one-way ANOVA test with Bonferroni correction was used to assess statistical significance and ...

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      Mentions: Heidelberg Engineering Francesco Bandello Luisa Pierro

    12. Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Explore American Journal of Ophthalmology Ophthalmology
      Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Purpose To use spectral domain-optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NAION). Design Retrospective cohort study. Methods.Setting Single academic center. Patient or study population Eighty eyes in 74 subjects presenting within 2 weeks of symptom onset of NAION. Intervention or observation procedures SD-OCT imaging of the optic nerve head, macula, and peripapillary retinal nerve fiber layer (pRNFL) were reviewed for PVD and vitreopapillary traction (VPT). Main Outcome Measures Prevalence and incidence of PVD and VPT, logMAR best-corrected visual ...

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      Mentions: Duke University

    13. Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography

      Explore Journals | PLOS Ophthalmology
      Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography

      Purpose To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes. Methods One hundred twenty-three eyes of 123 POAG patients were included from the Diagnostic Innovations in Glaucoma Study. The 3.0×3.0-mm optic nerve head OCTA scans were acquired using a spectral-domain OCT instrument. Images with whole-signal-mode were evaluated. Eyes were classified into 3 categories (Mvd-D, pseudo-Mvd-D, and no Mvd-D). Mvd-D and pseudo-Mvd-D had complete loss of OCTA signals on the temporal side of the optic disc on the en face ...

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      Mentions: National Institutes of Health Optovue Topcon Medical Systems

    14. PET-MR Imaging of Coronary Atherothrombosis

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      PET-MR Imaging of Coronary Atherothrombosis

      Heart attacks remain a common cause of death in the United Kingdom and throughout the world. The most common initiating event is the formation of a blood clot (thrombus) within the coronary arteries occluding blood supply to the heart. However, we know that thrombus often occurs within the coronary arteries without causing any symptoms, and may be found in patients with stable angina. We wish to investigate whether thrombus within the coronary arteries can be detected in patients who have had a heart attack and in patients with stable angina using combined positron emission tomography and magnetic resonance (PET-MR) imaging ...

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    15. Evaluation of Retinal Thickness in Neurodegenerative Diseases using Spectral Domain Optical Coherence Tomography

      Explore jcdr.net Neurology , Ophthalmology
      Evaluation of Retinal Thickness in Neurodegenerative Diseases using Spectral Domain Optical Coherence Tomography

      Introduction: Neurodegenerative diseases are characterised by axonal lesions throughout the central nervous system, including the eye with changes in macular thickness and Retinal Nerve Fiber Layer (RNFL) on histopathologic evaluation. Optical coherence tomography facilitates retina as a surrogate measure of neurodegenerative disease activity. Aim: To evaluate macular thickness and retinal nerve fiber layer thickness in patients with neurodegenerative diseases using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: An analytical observational case control study was carried out over a period of two years. Cases consisted of patients (n=20) with neurodegenerative disorders and controls were age and sex matched ...

      Read Full Article
      16. See all articles
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    Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography Mechanical/Optical Engineering Position at OCT Medical Imaging Inc. Postdoc Position in Biomedical Optics and Photonics at University of Western Australia Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images Axsun Technologies Announces Breakthrough Tunable VCSEL Platform for Optical Coherence Tomography (OCT) Imaging Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

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    1. The Ganymede series has proven to be an excellent tool for a multitude of imaging applications,...The Thorlabs OCT application team is available to assist with sample test runs and would be pleased to discuss how our OCT systems can be adapted to meet your needs.
      By Michael Leitner
    2. I am honored and incredibly excited to take on this leadership role during such a pivotal point in the company’s history and look forward to working with Merit Medical on our new strategic partnership. I would like to extend my sincere thanks to Chris for his service to NinePoint and mentorship to me over the past four-years. I am fortunate to be surrounded by a truly talented team with exciting and innovative products in the pipeline. Together, we look forward to continuing our important mission towards early detection of cancer.
      By Eman Namati
    3. We are thrilled to receive marketing clearance for our innovative AngioAnalytics technology as part of the AngioVue System to aid physicians in the early detection and management of sight-threatening eye diseases in the U.S.,” said Jay Wei, founder and chief executive officer of Optovue. “Analytic measurement tools will shift the treatment paradigm because they provide an objective measure of treatment efficacy, thereby enabling truly customized patient management and improved patient care...The information provided by AngioAnalytics may help to change the clinical management of diabetic retinopathy, age-related macular degeneration and other diseases that progressively cause blindness for millions of people. We will continue to advance AngioAnalytics as we believe quantification is the gateway to widespread and global adoption of OCTA.
      By Jay Wei
    4. This is the world's first intravascular imaging system for clinical use with the capability to acquire both IVUS and OCT images using a single catheter. IVUS and OCT are the two most commonly used intravascular imaging technologies in addition to angiography...The Novasight Hybrid System provides the resolution and contrast of OCT with the larger field of view of IVUS, and displays the images in a precisely co-registered fashion.
      By Brian K. Courtney
    5. We started with middle ear infections because of our personal experience with this disease as both parents and patients. Our novel application of optical coherence tomography revolutionizes the diagnosis, treatment and monitoring of the middle ear infections that affect 80% of children.
      By Ryan L. Shelton
    6. With the assistance of the next generation Pantheris system, we helped restore blood flow within the previously blocked segment of the artery and most importantly achieved a great outcome for the patient.
      By Arne G. Schwindt
    7. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen
    8. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    9. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    10. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei