Featured Articles

1. Topcon to Provide Free Cloud Storage on OCT Devices

   Explore Optical Coherence Tomography News Jan 16 2019 Ophthalmology , Other Business News

   

   Topcon Medical Systems (TMS) is pleased to announce an exciting new add-on feature for its state-of-the-art OCT product line. All Maestro SD OCT and Triton Swept Source OCT purchases will now come with 20GB of free storage on the new Topcon Cloud platform. Safely store OCT patient exam data all in the cloud w ith the new Topcon Cloud storage solution! Built as an add-on module for IMAGEnet® 6 software, Topcon Cloud is an automated, cloud-based, device backup solution that meets medical privacy requirements, provides scalable storage options, and supports disaster recovery plans. By transferring the storage of large files ...

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   Mentions: Topcon Medical Systems

2. High-Quality Imaging Brings Vision to Researchers and Patients

   Explore sbir.nih.gov Jan 13 2019 Other Business News

   

   The Beginning Macular degeneration is a disease that afflicts 11 million patients in the United States and is estimated to cost the global economy more than $300B annually. The first generation of Optical Coherence Tomography (OCT) was introduced to visualize retinal pathology and was finding a role in the monitoring treatments for age-related macular degeneration (AMD). This first-generation imaging technology suffered from low resolution and low speed. Joseph Izatt, Bioptigen’s scientific co-founder, recognized the value in a new implementation of OCT—Spectral Domain OCT—that operated up to 1000 times faster and had the potential for visualizing structures of ...

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   Mentions: National Institutes of Health Eric L. Buckland Bioptigen

3. Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

   Explore SAGE Journals Jan 12 2019 Dermatology

   

   Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology. OCT and its recent variant, dynamic OCT, permit rapid noninvasive depth-resolved imaging of the capillaries in the superficial dermis via a handheld probe ...

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   Mentions: Michelson Diagnostics University of Manchester Jon Holmes

4. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

   Explore Home - Springer Jan 12 2019 Gastroenterology

   

   Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barrett’s epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barrett’s tissue challenge BET measurements and the study of relationships between thickness and RFA outcomes. We aimed to quantify BET and compared the reliability of standard and contrast-enhanced VLE images. Methods Baseline VLE scans from BE ...

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   Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

5. Extended Coherence Length and Depth Ranging Using a Fourier-Domain Mode-Locked Frequency Comb and Circular Interferometric Ranging

   Explore journals.aps.org Jan 10 2019 Tunable Sources

   

   Fourier-domain mode locking has been a popular laser design for high-speed optical-frequency-domain imaging (OFDI), but achieving long coherence lengths, and therefore imaging range, has been challenging. The narrow linewidth of a Fourier-domain mode-locked (FDML) frequency-comb (FC) laser could provide an attractive platform for high-speed as well as long-range OFDI. Unfortunately, aliasing artifacts arising from signals beyond the principal measurement depth of the free spectral range have prohibited the use of an FDML FC laser for imaging so far. To make the increased coherence length of an FDML FC laser available, methods to manage such artifacts are required. Recently, coherent circular ...

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   Mentions: Brett E. Bouma Massachusetts Institute of Technology Massachusetts General Hospital

6. Santec Announce a Record Wavelength Scan for an Electrically Pumped VCSEL

   Explore Optical Coherence Tomography News Jan 9 2019 Other Business News , Tunable Sources

   

   Santec Corporation (JASDAQ: 6777) Santec, a leading manufacturer of tunable lasers, optical instruments, and fiber-optic components, announces a record 88nm wide continuous wavelength scan for an electrically pumped VCSEL (Vertical Cavity Surface Emitting Laser) light source. This performance record for a 1050nm centered VCSEL is a result of a collaborative effort between Santec, Tokyo Institute of Technology and Tokyo University’s Institute of Industrial Science. This result will be reported at the upcoming Photonics West 2019 meeting in San Francisco [1]. The High-speed Scanning Tunable VCSEL’s element is made up of two parts; the VCSEL, responsible for laser oscillation ...

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   Mentions: Santec Hiroshi Toshiyoshi Tokyo Institute of Technology

7. Acqiris launches the break-through SA2 signal acquisition platform starting with the SA220 14-bit, 2 GS/s ADC Card, designed for easy integration

   Explore Optical Coherence Tomography News Jan 8 2019 Other Business News

   

   Acqiris, a leader in high-speed signal acquisition, today launched the new SA220 14-bit ADC card, the first addition to our new exciting SA2 platform, specifically designed to uniquely address OEM application needs without compromise. The SA2 platform is first on the market to be especially optimized for OEM requirements. It leverages Acqiris’ new high-performance 14-bit ADC card technology which performs fast signal acquisitions from 1 GS/s up to 10 GS/s, with excellent signal fidelity across a wide bandwidth. The SA220 is an entry model of the SA2 new product generation and a unique DC-coupled acquisition card, featuring: 14-bit ...

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   Mentions: Keysight Technologies Acqiris

8. Thorlabs Extends VEGA Swept Source OCT Offering

   Explore Optical Coherence Tomography News Jan 7 2019 Other Business News , Tunable Sources

   

   Thorlabs announced today that it has added to its well‐established VEGA™ OCT line by releasing complete imaging systems, VEG210C1 and VEG220C1. Based on Thorlabs’ MEMS‐VCSEL swept‐wavelength laser source technology, these new systems are available in both 100 kHz (VEG210) and 200 kHz (VEG220) variants. Both offer the same low roll‐off and high sensitivity performance found in previous members of the VEGA OCT family. The MEMS‐VCSEL swept source and the imaging module are both packaged into a single housing including the scanning electronics and an interferometer with a balanced detector. Several key hardware controls can be ...

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   Mentions: Thorlabs Michael Leitner

9. Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success

   Explore Optical Coherence Tomography News Jan 4 2019

   

   On December 14 and 15 2018, over 1400 ophthalmologists participated in Rome at tha most important meeting on OCT and OCT Angiography. the 6th international meeting on OCT Angiography, advances in OCT . The organizer, Dr Lumbroso has, since he started to organize these meetings, a well-defined objective: informing ophthalmologist in any country on the new clinical possibilities of Ocular imaging. The policy is to invite the best speakers in the world to teach basics and new developments to eager young ophthalmologists. The conference and talks by prominent specialists confirmed that OCTA opens new horizons and conveys new points of view ...

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   Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto

10. Volumetric analysis of breast cancer tissues using machine learning and swept-source optical coherence tomography

    Explore OSA | OSA Publishing Jan 3 2019 Oncology

    

    In breast cancer, 20%–30% of cases require a second surgery because of incomplete excision of malignant tissues. Therefore, to avoid the risk of recurrence, accurate detection of the cancer margin by the clinician or surgeons needs some assistance. In this paper, an automated volumetric analysis of normal and breast cancer tissue is done by a machine learning algorithm to separate them into two classes. The proposed method is based on a support-vector-machine-based classifier by dissociating 10 features extracted from the A-line, texture, and phase map by the swept-source optical coherence tomographic intensity and phase images. A set of 88 ...

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    Mentions: Dalip Singh Mehta Indian Institute of Technology at Delhi UCLA

11. System Engineer / Senior System Engineer Opening at NinePoint Medical

    Explore Optical Coherence Tomography News Jan 3 2019 Jobs & Studentships

    

    The Company: NinePoint Medical is a fast-paced medical device start-up based out of Bedford MA. With our recent strategic investment from Merit Medical, we are expanding our product development team. We develop, manufacture and commercialize cutting-edge medical imaging products with a big vision to detect, diagnose, and treat cancer before it becomes cancer. Today’s standard of care for diagnosis of disease relies on obtaining a tissue sample and performing costly processing and expert review of tissue sections. Using breakthrough optical imaging technology along with advanced machine learning algorithms, NinePoint Medical will provide treating physicians with real-time diagnostic capability, thus ...

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    Mentions: NinePoint Medical

12. Postdoc Position at Vanderbilt University

    Explore Optical Coherence Tomography News Jan 2 2019 Jobs & Studentships

    

    Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to join our lab for an exciting project to poised to make a major impact in the medical fields of urology and gastroenterology. The proposed project builds on previous work from ...

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    Mentions: Vanderbilt University Stanford University Harvard University

13. Long-to-short wavelength swept source

    Explore OSA | OSA Publishing Dec 22 2018 Tunable Sources

    

    Most swept external cavity diode lasers tune in the short-to-long wavelength direction (red tuning). Lower relative intensity noise (RIN) and higher output power are typically possible in this direction. We show here that long-to-short tuning (blue tuning) is possible for a short, linear cavity laser that has both low noise and high power. This mode of operation is made possible by nonlinear frequency broadening in the semiconductor optical amplifier (SOA) followed by clipping of the red portion of the spectrum by the micro-electro-mechanical systems (MEMS) tunable Fabry-Perot filter. Blue shifting during gain recovery is an important broadening mechanism. There is ...

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    Mentions: Axsun Technologies Dale Flanders Brian D. Goldberg

14. OCTID: Optical Coherence Tomography Image Database

    Explore arxiv.org Dec 22 2018 Ophthalmology

    

    Optical coherence tomography (OCT) is a non-invasive imaging modality which is widely used in clinical ophthalmology. OCT images are capable of visualizing deep retinal layers which is crucial for the early diagnosis of retinal diseases. In this paper, we describe a comprehensive open-access database containing more than 500 high-resolution images categorized into different pathological conditions. The image classes include Normal (NO), Macular Hole (MH), Age-related Macular Degeneration (AMD), Central Serous Retinopathy, and Diabetic Retinopathy (DR). The images were obtained from a raster scan protocol with a 2mm scan length and 512x1024 pixels resolution. We have also included 25 normal OCT ...

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    Mentions: University of Waterloo

15. Small HDL Subclass is Associated with Coronary Plaque Stability: An Optical Coherence Tomography Study in Patients with Coronary Artery Disease

    Explore ScienceDirect Dec 22 2018 Cardiology

    

    Background The role of high-density lipoprotein (HDL) subclasses in atherosclerotic diseases remains an open question. Previous clinical trials have attempted to explore the predictive effect of HDL subspecies on cardiovascular risk. However, no studies have assessed the connections between these subclasses and characteristics of plaque microstructure. Objective To investigate the relationship of HDL subclasses and coronary plaque stability assessed by optical coherence tomography (OCT). Methods Morphological characteristics of 160 non-target lesions from 85 patients with coronary artery disease were assessed by OCT. High-density lipoprotein (HDL) subclass profiles were analyzed using non-denaturing polyacrylamide gel electrophoresis. Results The plasma levels of small ...

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    Mentions: Harbin Medical University Jingbo Hou Bo Yu

16. PhD Opening in Optical Coherence Tomography at University of Kent

    Explore Optical Coherence Tomography News Dec 22 2018 Jobs & Studentships

    

    Project Description A PhD position is available in the field of Biophotonics. This project is in competition with other projects offered by the School of Physical Sciences for one of a number of EPSRC Doctoral Training Partnership Studentships. The aim of this project is to advance the technology of optical coherence tomography (OCT). OCT has a range of applications in medical imaging and the project can focus on one of the areas of rapid development such as Master Slave and Down-conversion OCT methods, prototyping OCT assemblies, or advancing the technology of OCT components such as the optical source or ultra ...

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    Mentions: Adrian G. Podoleanu University of Kent

17. Repeatability and Reproducibility of Quantification of Superficial Peri-papillary Capillaries by four Different Optical Coherence Tomography Angiography Devices

    Explore Nature Publishing Group Dec 19 2018 Ophthalmology

    

    This study was performed to test the repeatability and reproducibility of measurements of peri-papillary capillaries from four optical coherence tomography angiography (OCTA) devices. 109 healthy eyes were imaged with four OCTA devices (Spectralis, Optovue, Triton and Cirrus). A 3 × 3 mm scan pattern centered on the disc was repeated twice by each device. En face images of superficial capillary plexus were screened and processed for calculation. Vessel length density (VLD) was calculated on four equally divided parts of a ring between two concentric circles manually centered on the disc. General linear model (GLM) was used to test the impact of ...

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    Mentions: Optovue Heidelberg Engineering Topcon Medical Systems

18. Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study

    Explore ScienceDirect Dec 19 2018 Cardiology

    

    Objectives This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment. Background OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Methods In the IBIS-4 (Integrated Biomarker Imaging Study-4), 103 patients underwent intravascular ultrasonography and OCT of 2 noninfarct-related coronary arteries in the acute phase of STEMI. Patients were treated with high-dose rosuvastatin for ...

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    Mentions: Imperial College London Leiden University University of Copenhagen

19. Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market

    Explore Optical Coherence Tomography News Dec 17 2018 Ophthalmology , Other Business News

    

    First U.S. clinical trial initiated with patient-operated home OCT device for monitoring patients diagnosed with exudative age-related macular degeneration (eAMD) Notal Vision, Inc., (“Notal”) a privately-held ophthalmic diagnostic services company, focused on advancing eye care by extending ophthalmic disease management from the clinic to the home, has announced the achievement of a significant milestone in its plan to develop and commercialize a home-based, patient-operated, spectral-domain optical coherence tomography (SD-OCT) system. The first targeted application of the Notal Home OCT is to monitor exudative (wet) age-related macular degeneration (eAMD) patients between scheduled, standard-of-care examinations by their treating retinal specialist. Notal ...

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    Mentions: Wasatch Photonics FDA Nishant Mohan

20. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

    Explore archivesofpathology.org Dec 16 2018 Urology

    

    Context.— The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (μOCT) that generates depth-resolved tissue images at a high frame rate with an isotropic resolution of 1 μm. Objective.— To demonstrate that optical images obtained with μOCT provide cellular-level contrast in prostate specimens ...

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    Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

21. In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

    Explore archivesofpathology.org Dec 15 2018 Microscopy

    

    The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or also in freshly excised tissue, termed ex vivo microscopy. Both in vivo and ex vivo microscopy have tremendous potential for clinical impact in a wide variety of applications. However, in ...

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    Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

22. Moody's says Excelitas' proposed $80 million first lien term loan facility to acquire Axsun is a moderate credit negative; ratings unaffected

    Explore Optical Coherence Tomography News Dec 12 2018 Acquisition , Other Business News

    

    Moody's Investors Service ("Moody's") says EXC Holdings III Corp.'s (dba Excelitas) proposed $80 million incremental first lien term loan facility to fund the acquisition of Axsun is a modest credit negative, but it does not impact the company's B3 Corporate Family Ratings or stable rating outlook. Following the add-on, the USD denominated first lien term loan will increase to $685 million from $605 million ($681 million outstanding proforma at September 30, 2018). The $80 million proceeds along with $1.2 million of cash on hand will be used to fund the acquisition and approximately $5 million ...

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    Mentions: Axsun Technologies

23. Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples

    Explore arxiv.org Dec 11 2018

    

    Optical coherence tomography (OCT) is being increasingly adopted as a label-free and non-invasive technique for biomedical applications such as cancer and ocular disease diagnosis. Diagnostic information for these tissues is manifest in textural and geometric features of the OCT images which are used by human expertise to interpret and triage. However, it suffers delays due to long process of conventional diagnostic procedure and shortage of human expertise. Here, a custom deep learning architecture, LightOCT, is proposed for classification of OCT images into diagnostically relevant classes. LightOCT is a convolutional neural network with only 2 convolutional layers and a fully connected ...

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    Mentions: Dalip Singh Mehta Indian Institute of Technology at Delhi Nanyang Technological University

24. Direct comparison of optical coherence tomography and high-definition 60-MHz intravascular ultrasound imaging of intra-procedural stent thrombosis in a patient with acute coronary syndrome

    Explore ScienceDirect Dec 11 2018 Cardiology

    

    An 80-year-old man with ST-segment elevation myocardial infraction underwent coronary stenting using an everolimus-eluting stent, which resulted in a good coronary flow with no residual stenosis. However, 10 min after final coronary angiography, the patient complained of chest discomfort and the ECG again showed ST elevation. Repeat coronary angiography revealed multiple contrast filling defects in the stent. High-definition 60-MHz intravascular ultrasound (IVUS) examination showed multiple low echoic structures inside the stent, though its visualization was not clear. We also conducted optical coherence tomography (OCT) for further investigation, which clearly delineated the outline of the thrombus. An additional balloon dilatation was ...

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    Mentions: Kyoto University Graduate School of Medicine
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