1. Featured Articles

    1. Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging

      Explore Nature Publishing Group
      Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging

      Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting efficient noise suppression via coherent averaging and a simple computational bandwidth expansion procedure. We demonstrate a resolution enhancement of 1.5 × relative to the aberration-free limit while maintaining comparable SNR ...

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      Mentions: Cornell University

    2. Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography

      Explore ACS Publications Home Page
      Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography

      Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral contrast (SC)-OCT measurements, we can distinguish signatures of different gold nanobipyramids (GNBPs) in lymphatic vessels from the surrounding tissue and blood vessels in live mouse models. This technique could ...

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      Mentions: Massachusetts General Hospital Stanford University Harvard University

    3. Notal Vision Reports Results from First U.S. Home OCT Feasibility Study

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      Notal Vision Reports Results from First U.S. Home OCT Feasibility Study

      Notal Vision, Inc. reported today that results of the first U.S.-based feasibility study with its investigational home-based optical coherence tomography (OCT) platform were presented at the Retina Society and the American Society of Retina Specialists (ASRS) annual meetings. The Notal Home OCT pipeline technology is designed to provide patient-initiated retinal OCT scans to support the management of patients with wet age-related macular degeneration (AMD), complementing existing standard of care treatments as well as emerging longer acting drugs and drug delivery systems. The study evaluated the ability of subjects with wet AMD to perform sequential daily self-imaging of their ...

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      Mentions: Notal Vision

    4. Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Explore Optical Coherence Tomography News Gynecology , Funding
      Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography.

      Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...

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      Mentions: Glannaventa, Inc.

    5. Simultaneous directional full-field OCT using path-length and carrier multiplexing

      Explore OSA | OSA Publishing
      Simultaneous directional full-field OCT using path-length and carrier multiplexing

      Full-field swept-source optical coherence tomography (FF-SS-OCT) is an emerging technology with potential applications in ophthalmic imaging, microscopy, metrology, and other domains. Here we demonstrate a novel method of multiplexing FF-SS-OCT signals using carrier modulation (CM). The principle of CM could be used to inspect various properties of the scattered light, e.g. its spectrum, polarization, Doppler shift, or distribution in the pupil. The last of these will be explored in this work, where CM was used to acquire images passing through two different optical pupils. The two pupils contained semicircular optical windows with perpendicular orientations, with each window permitting measurement ...

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      Mentions: UCSD

    6. Line-field confocal optical coherence tomography as a tool for three-dimensional in vivo quantification of healthy epidermis: a pilot study

      Explore Wiley Online Library Dermatology
      Line-field confocal optical coherence tomography as a tool for three-dimensional in vivo quantification of healthy epidermis: a pilot study

      Epidermal three-dimensional (3D) topography/quantification have not been completely characterized yet. The recently developed line-field confocal optical coherence tomography (LC-OCT) provides real-time, high-resolution, in-vivo 3D imaging of the skin. This pilot study aimed at quantifying epidermal metrics [epidermal thicknesses, dermal-epidermal junction (DEJ) undulation and keratinocyte number/shape/size] using 3D LC-OCT. For each study participant (8 female, skin-type-II, younger/older volunteers), seven body sites were imaged with LC-OCT. Epidermal metrics were calculated by segmentations and measurements assisted by artificial intelligence (AI) when appropriate. Thicknesses of epidermis/SC, DEJ undulation and keratinocyte nuclei volume varied across body sites. Evidence of keratinocyte ...

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    7. 114 nm broadband all-fiber nonlinear polarization rotation mode locked-laser and time-stretch optical coherence tomography

      Explore OSA | OSA Publishing
      114 nm broadband all-fiber nonlinear polarization rotation mode locked-laser and time-stretch optical coherence tomography

      We propose and demonstrate an all-fiber Er-doped mode-locked laser with a 3-dB spectrum of 114 nm by using nonlinear polarization rotation (NPR), which to the best of our knowledge is the first realization to date of such a broad spectrum without any spatial optical devices. The repetition rate and pulse width of the laser are 183.6 MHz and 3.7 ps, respectively. Such an all-fiber NPR mode-locked laser is then applied in time-stretch optical coherence tomography. The axial resolution is 12.1 µm. The all-fiber high speed broadband swept laser based on the time stretching technique has compact structure ...

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    8. What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021

      Explore Optical Coherence Tomography News Otolaryngology
      What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021

      This free, live event will take place on October 6 th, 10 EDT (4 PM CET) and will include an interactive Q&A session. For information and to register please visit this link. After the event a recorded version will be available at www.thorlabs.com/webinars . Abstract: Drs. Elizabeth Olson and Elliott Strimbu from Columbia University will highlight Phase Sensitive Spectral Domain Optical Coherence Tomography as it relates to nanoscale vibrometry. They will cover in detail the performance parameters of a Thorlabs Telesto for nanoscale displacement measurements in the cochlea and leverage their years of experience in the field ...

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      Mentions: Thorlabs Columbia University

    9. Luneau Technology Group merges with Optovue

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Luneau Technology Group merges with Optovue

      Luneau Technology Group announced that its merger with Optovue Inc. will enable the two companies to offer a comprehensive portfolio of health solutions to eye care providers. “We’re two agile companies with a startup mentality of innovation and flexibility,” Marc Abitbol, PhD, CEO of the newly merged company, said in a press release. “Together, we now have a full pipeline that covers everything for visual health. Optovue’s OCT expertise, stellar reputation and primary position in the medical eye care market and complementary portfolio of products make us an ideal partner, so our combined company can offer complete end-to-end ...

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      Mentions: Optovue
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  2. Recent Articles From Around The Web

    1. Anterior segment optical coherence tomography findings in leukemic iris infiltration

      Explore ScienceDirect Ophthalmology
      Anterior segment optical coherence tomography findings in leukemic iris infiltration

      Iris involvement by acute lymphoblastic leukemia is a very rare primary leukemic infiltration. Blurred vision, conjunctival injection, anterior chamber reaction, pseudohypopyon, thickening of the iris stroma, change in iris shape and color are common clinical signs in leukemic iris infiltration. There is no optimal treatment. Radiotherapy, systemic chemotherapy (high-dose of methotrexate and/or high-dose cytarabine), topical and systemic corticosteroids have been reported as treatment modalities. Herein we present anterior segment optical coherence tomography findings in a 21-years-old, male, diffuse B-cell Acute Lymphoblastic Leukemia (ALL) patient who has a leukemic iris infiltration in his left eye that was successfully treated with ...

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    2. Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT

      Explore Home - Springer Ophthalmology
      Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT

      Purpose: To investigate the value of pattern electroretinography (PERG) and photopic negative response (PhNR) in monitoring glaucoma compared to standard clinical tests (standard automated perimetry (SAP) and clinical optic disc assessment) and structural measurements using spectral-domain OCT. Methods: A prospective study included 32 subjects (32 eyes) with ocular hypertension, suspect or early glaucoma monitored for progression with clinical examination, SAP, PERG, PhNR and OCT for at least 4 years. Progression was defined clinically by the documented change of the optic disc and/or significant visual field progression (EyeSuite™ trend analysis). One eye per patient was included in the analysis. Results ...

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    3. Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Explore LWW Online Ophthalmology
      Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Purpose: To assess the dimensions of the limbus-sulcus region measured by swept-source optical coherence tomography (SS-OCT) and correlation study in a large healthy population. Setting: Centro Internacional de Oftalmología Avanzada. Design: Cross-sectional study. Methods: The dimensions of the limbus-sulcus region were measured in 625 eyes of 625 subjects in the temporal and nasal quadrants using a SS-OCT. The limbus-sulcus distance (LSD), the posterior iris line-ocular surface to limbus distance (PIOLD) and the angle to sulcus distance (ASD) were measured. These distances were then assessed for correlations with the factors age, sex, refractive error, anterior chamber angle (ACA), ciliary muscle ...

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    4. Digital ocular swept source optical coherence aberrometry

      Explore OSA | OSA Publishing Ophthalmology
      Digital ocular swept source optical coherence aberrometry

      Ocular aberrometry is an essential technique in vision science and ophthalmology. We demonstrate how a phase-sensitive single mode fiber-based swept source optical coherence tomography (SS-OCT) setup can be employed for quantitative ocular aberrometry with digital adaptive optics (DAO). The system records the volumetric point spread function at the retina in a de-scanning geometry using a guide star pencil beam. Succeeding test-retest repeatability assessment with defocus and astigmatism analysis on a model eye within ± 3 D dynamic range, the feasibility of technique is demonstrated in-vivo at a B-scan rate of >1 kHz in comparison with a commercially available aberrometer.

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      Mentions: Medical University of Vienna

    5. New diagnostic and imaging technologies in dermatology

      Explore Wiley Online Library Dermatology
      New diagnostic and imaging technologies in dermatology

      Introduction Diagnosis of dermatological disorders is primarily based on clinical examination in combination with histopathology. However, clinical findings alone may not be sufficient for accurate diagnosis and cutaneous biopsies are being associated with morbidity. Objective The objective of this article is to review the newer technologies along with their applications, limitation and future prospectus. Methodology Comprehensive literature search was performed using electronic online databases “PubMed” and “Google Scholar”. Articles published in English language were considered for the review. Results In order to improve and/or widen the armamentarium in dermatologic disease diagnosis and therapy, newer emerging technologies are being made ...

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    6. A comparison of different methods to calculate the axial length measured by optical biometry

      Explore LWW Online Ophthalmology
      A comparison of different methods to calculate the axial length measured by optical biometry

      Purpose To compare axial length (AL) measurements in long eyes by two swept-source optical coherence tomography (SS-OCT) biometers, one based on the group refractive index (IOLMaster 700, Zeiss) and the other based on sum of segments (Argos, Movu), and compare these measurements to previously published methods to optimize AL. Setting I.R.C.C.S. - G.B. Bietti Foundation, Rome, Italy Design Prospective case series Methods AL was measured with both optical biometers in myopic patients (AL > 24.00 mm) and compared to the values obtained with Wang-Koch adjustment, polynomial equations for the Holladay 1 and 2 formulas and Cooke ...

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      Mentions: Movu

    7. Retinal Microvascular and Perfusional Disruption in Paediatric COVID-19: A Case-Control Optical Coherence Tomography Angiography Study

      Explore ScienceDirect Ophthalmology
      Retinal Microvascular and Perfusional Disruption in Paediatric COVID-19: A Case-Control Optical Coherence Tomography Angiography Study

      Purpose: To investigate the short-term effect of coronavirus 2019 (COVID-19) on the retinal capillary network and choroid in children. Materials and methods: This prospective, cross-sectional, case-control study included 19 recovered COVID-19 paediatric patients and 20 healthy children. Macular thickness, choroidal thickness, vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) values were obtained. Central vessel and perfusion densities were measured at the central 6-mm area, and the values were compared among three subgroups according to location. Results: The mean ages of patients and controls were 12.42 ± 3.3 years and 13.35 ± 1.2 years, respectively. Significant ...

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    8. A Quantitative Model for Optical Coherence Tomography

      Explore MDPI Open Access Journals Platform
      A Quantitative Model for Optical Coherence Tomography

      Optical coherence tomography (OCT) is a widely used imaging technique in the micrometer regime, which gained accelerating interest in medical imaging in the last twenty years. In up-to-date OCT literature, certain simplifying assumptions are made for the reconstructions, but for many applications, a more realistic description of the OCT imaging process is of interest. In mathematical models, for example, the incident angle of light onto the sample is usually neglected or a plane wave description for the light–sample interaction in OCT is used, which ignores almost completely the occurring effects within an OCT measurement process. In this article, we ...

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      Mentions: Medical University of Vienna

    9. Acute Posterior Ocular Toxoplasmosis: An Optical Coherence Tomography Angiography and Dye Angiography Study

      Explore Taylor & Francis Online Ophthalmology
      Acute Posterior Ocular Toxoplasmosis: An Optical Coherence Tomography Angiography and Dye Angiography Study

      Purpose: To compare Indocyanine Green (ICGA) and fundus fluorescein angiography (FFA) with Optical Coherence Tomography Angiography (OCTA) findings in toxoplasmic chorioretinitis (TCR). Methods: Patients affected by active TCR were included. FFA, ICGA, and OCTA images were analyzed and lesions were compared between different modalities. Satellite dark dots (SDD) were compared between modalities. Results: Fifteen patients were enrolled. The mean lesion area was similar between fundus photography (FP), FFA, and OCTA-Retina. The mean lesion area was similar between ICGA and OCTA-Choroid slab. ICGA and OCTA-Choroid showed a larger extension of the lesion compared to FP, FFA, and OCTA-Retina ( p = .01, 0 ...

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    10. Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

      Explore Wiley Online Library
      Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

      Optical imaging in the second near infrared region (NIR-II, 1000–1700 nm) provides higher resolution and deeper penetration depth for accurate and real-time vascular anatomy, blood dynamics, and function information, effectively contributing to the early diagnosis and curative effect assessment of vascular anomalies. Currently, NIR-II optical imaging demonstrates encouraging results including long-term monitoring of vascular injury and regeneration, real-time feedback of blood perfusion, tracking of lymphatic metastases, and imaging-guided surgery. This review summarizes the latest progresses of NIR-II optical imaging for angiography including fluorescence imaging, photoacoustic (PA) imaging, and optical coherence tomography (OCT). The development of current NIR-II fluorescence, PA ...

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    11. Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study

      Explore Journals | PLOS Ophthalmology
      Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study

      Objective To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA). Methods Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: < 24.0 mm; 35 eyes), Group 2 (AL: 24.0–25.99 mm; 37 eyes), and Group 3 (AL: ≥ 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6× 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated ...

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      Mentions: Carl Zeiss Meditec Chungnam National University Hospital

    12. Imaging of iris vasculature: current limitations and future perspective

      Explore Nature Publishing Group Ophthalmology
      Imaging of iris vasculature: current limitations and future perspective

      Fluorescein and indocyanine green angiography have been the traditional ways to image the vasculature of the iris in the last few decades. Because of the invasive nature of these procedures, they are performed in rare situations, and thus, our understanding about iris vasculature is very limited. Optical coherence tomography angiography (OCTA) is a noninvasive imaging method that enables the detailed visualization of the retinal and choroidal vascular networks. More recently, it has been also used for the examination of the iris vasculature in healthy and disease eyes. However, there is a lack of uniformity in the image acquisition protocols and ...

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    13. Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study

      Explore Home - Springer Ophthalmology
      Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study

      Background/aims: To quantify the longitudinal changes of the macular microvasculature and the foveal avascular zone (FAZ) parameters in patients recovered from coronavirus disease-2019 (COVID-19) using optical coherence tomography angiography (OCTA) analysis. Methods: This observational, longitudinal study was performed on patients recovered from COVID-19. The OCTA images were recorded at baseline and after 1 and 3 months at the follow-up examination. Vessel density (VD) of the retinal superficial (SCP) and deep capillary plexus (DCP), as well as the area of the FAZ of patients who had recovered from COVID-19, were measured. Results: In total, 36 eyes of 18 patients (62 ...

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    14. Altered peripapillary vessel density and nerve fiber layer thickness in thyroid-associated ophthalmopathy using optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      Altered peripapillary vessel density and nerve fiber layer thickness in thyroid-associated ophthalmopathy using optical coherence tomography angiography

      Objective: To measure the peripapillary vessel density (VD) and retinal nerve fiber layer thickness (RNFLT) in thyroid-associated ophthalmopathy (TAO) and dysthyroid optic neuropathy (DON) patients using optical coherence tomography angiography (OCTA), and determine their prognostic relevance. Methods: Forty-three TAO patients with or without DON (82 eyes in total) and 26 healthy subjects (52 eyes) were enrolled. All participants underwent ophthalmology and endocrinology tests. The peripapillary VD in retinal peripapillary capillary layer and RNFLT were analyzed using OCTA images. Multiple linear regression analysis was used to assess the relationship between peripapillary VD /RNFLT and the relevant factors. Results: The total peripapillary ...

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    15. Investigation of the Retinal and Optic Disc Microvascularization in Polycystic Ovary Syndrome: An Optical Coherence Tomography Angiography Study

      Explore Taylor & Francis Online Ophthalmology
      Investigation of the Retinal and Optic Disc Microvascularization in Polycystic Ovary Syndrome: An Optical Coherence Tomography Angiography Study

      Purpose: To investigate retinal and optic disc microvascular alterations using optical coherence tomography angiography (OCTA) in women with polycystic ovary syndrome (PCOS). Methods: Forty-six eyes of 23 patients with PCOS (PCOS group), and 50 eyes of 25 sex and age-matched healthy controls (control group) were included in this cross-sectional study. Foveal retinal thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of the retina and optic disc were analyzed by OCTA. Results: The superficial parafoveal vessel densities were significantly lower in PCOS group compared to the control group (53.7 ± 4.0%, and 55.4 ± 2 ...

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      16. See all articles
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    Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography Notal Vision Reports Results from First U.S. Home OCT Feasibility Study Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. Simultaneous directional full-field OCT using path-length and carrier multiplexing Line-field confocal optical coherence tomography as a tool for three-dimensional in vivo quantification of healthy epidermis: a pilot study 114 nm broadband all-fiber nonlinear polarization rotation mode locked-laser and time-stretch optical coherence tomography What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021 Luneau Technology Group merges with Optovue Anterior segment optical coherence tomography findings in leukemic iris infiltration Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

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    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
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