1. Recent Articles From Around The Web

    1. Subcellular Comparison of Visible-Light Optical Coherence Tomography and Electron Microscopy in the Mouse Outer Retina

      Subcellular Comparison of Visible-Light Optical Coherence Tomography and Electron Microscopy in the Mouse Outer Retina

      Purpose: We employed in vivo, 1.0-µm axial resolution visible-light optical coherence tomography (OCT) and ex vivo electron microscopy (EM) to investigate three subcellular features in the mouse outer retina: reflectivity oscillations inner to band 1 (study 1); hyperreflective band 2, attributed to the ellipsoid zone or inner segment/outer segment (IS/OS) junction (study 2); and the hyperreflective retinal pigment epithelium (RPE) within band 4 (study 3). Methods: Pigmented (C57BL/6J, n = 10) and albino (BALB/cJ, n = 3) mice were imaged in vivo. Enucleated eyes were processed for light and electron microscopy. Using well-accepted reference surfaces, we ...

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    2. Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics

      Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics

      Purpose: To determine if diabetic retinopathy (DR) severity affects quadrant asymmetry (QA) of optical coherence tomography angiography (OCTA) metrics differentially. Methods: Ninety eyes (60 patients) with no diabetes mellitus (DM) (n = 39) or varying levels of DR (n = 51) had OCTA images (3 × 3 mm, Cirrus5000) acquired five times and averaged. The vessel length density (VLD) and perfusion density (PD) of the superficial retinal layer (SRL) and deep retinal layer (DRL) were measured. QA was defined as the maximum minus minimum value among four parafoveal Early Treatment Diabetic Retinopathy quadrants, and compared with DR severity by linear regression including fixed ...

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    3. Customized fiber generates Bessel beams

      Customized fiber generates Bessel beams

      An all fiber-based approach to generating special optical beams, called Bessel beams, could open up new applications in imaging, optical trapping and communications. Bessel beams look quite different from the usual Gaussian light beams found in optics. In particular, they possess several interesting properties including self-healing, diffraction-free propagation and the ability to carry orbital angular momentum (OAM). This family of beams—also known as vortex beams with a characteristic ring-like shape and a dark central region—include different "orders" of beams carrying different values of OAM.

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    4. PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX)

      PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX)

      There has been ample evidence of the role of intracoronary imaging for optimizing the stent, especially among the patients with complex coronary lesions. Intracoronary imaging can be used during the entire process of percutaneous coronary intervention (PCI), from pre-PCI to post-PCI stages. Notably, approximately 15-20% of patients who underwent angiographically successful PCI showed significant stent underexpansion, malapposition, intra-stent thrombus formation, and edge dissection on intracoronary imaging studies, including optical coherence tomography (OCT). Meanwhile, the role of pre-interventional fractional flow reserve (FFR) measurement has been well established and recommended by recent guideline. However, although previous studies evaluated the efficacy and safety ...

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    5. Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation

      Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation

      Purpose: To develop and validate a risk score assessable in real-time using only retinal thickness-related values measured by spectral domain optical coherence tomography alone for use in population-based glaucoma mass screenings. Methods: A total of 7572 participants (aged 35-74 years) underwent spectral domain optical coherence tomography examination annually between 2016 to 2021 in a population-based setting. We selected 284 glaucoma cases and 284 controls, matched by age and sex, from 11,487 scans in 2016. We conducted multivariable logistic regression with backward stepwise selection of retinal thickness-related variables to develop the diagnostic models. The developed risk scores were applied to ...

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    6. Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease

      Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease

      Background Diabetic retinopathy and retinal vein occlusion are vision threatening retinal vascular diseases. Current first-line therapy targets the vascular component, but many patients are treatment-resistant due to unchecked inflammation. Non-invasive inflammatory imaging biomarkers are a significant unmet clinical need for patients. Imaging of macrophage-like cells on the surface of the retina using clinical optical coherence tomography (OCT) is an emerging field. These cells are increased in patients with retinal vascular disease, and could be a potential inflammatory biomarker. However, since OCT is limited by an axial resolution of 5–10 microns, the exact location and identity of these retinal cells ...

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    7. Vertical scan imaging of Anterior Segment Optical Coherence Tomography for descemet anchoring caterpillar seta: A case report and review of literature

      Vertical scan imaging of Anterior Segment Optical Coherence Tomography for descemet anchoring caterpillar seta: A case report and review of literature

      Purpose To report Anterior Segment Optical Coherence Tomography (ASOCT) characteristic and its usefulness in the case of Descemet's membrane (DM) anchoring caterpillar seta, highlighting the importance of vertical scans of ASOCT in detecting and delineating the deep seta and its anterior chamber (AC) penetration. Observation A 30-year-old male patient presented with complaints of foreign body sensation and watering in the left eye after falling of an insect. Slit-lamp examination showed the presence of two caterpillar hairs, one embedded in the superficial conjunctiva and the second one embedded in the corneal stroma . Conjunctival hair was removed leading to the resolution ...

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    8. Evaluation of signal degradation due to birefringence in a multiple reference optical coherence tomography system with polarization-based balanced detection

      Evaluation of signal degradation due to birefringence in a multiple reference optical coherence tomography system with polarization-based balanced detection

      Although time-domain optical coherence tomog- raphy (TD-OCT) systems are straightforward to realize, the imaging speed, sensitivity, and imaging depth limit their range of applications. Multiple reference optical coherence tomography (MR-OCT) based on TD-OCT increases imaging range by about tenfold while providing sensitivity to image highly scattering biological samples. The multiple path-delays and free- space construction make MR-OCT also interesting for hybrid and compact systems, filling the gap between fibre-based and wafer-level integrated optical systems. We describe an optical configuration using a balanced detection scheme and the resulting signal properties due to the required use of polarizing optical components. We numerically ...

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    9. An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images

      An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images

      Laser-induced choroidal neovascularization (L-CNV) in murine models is a standard method for assessing therapies, genetics, and mechanisms relevant to the blinding eye disease neovascular or “wet” age-related macular degeneration. The ex vivo evaluation of these lesions involves confocal microscopy analysis. In vivo evaluation via optical coherence tomography (OCT) has previously been established and allows longitudinal assessment of lesion development. However, to produce robust data, evaluation of many lesions may be required, which can be a slow, arduous process. A prior, manual method for quantifying these lesions as ellipsoids from orthogonal OCT images was effective but time consuming. We therefore investigated ...

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    10. Multimodal Imaging Including Swept Source Optical Coherence Tomography Angiography in A Case with Sclerochoroidal Calcification

      Multimodal Imaging Including Swept Source Optical Coherence Tomography Angiography in A Case with Sclerochoroidal Calcification

      Purpose: We report a case of idiopathic sclerochoroidal calcification (SCC) evaluated with multimodal imaging including swept source optical coherence tomography angiography (SS-OCTA). Case presentation: A 52-year-old man was diagnosed with sclerochoroidal calcification in the left eye. Multimodal imaging revealed mixed hypoautofluorescence and hyperautofluorescence on fundus autofluorescence (FAF) imaging; an acoustically solid lesion with hyperreflective deposits on ultrasonography (USG); a rocky configuration with marked disruption of outer retinal layers and abrupt transition from normal to tumor tissue on swept source optical coherence tomography (SS-OCT); outer retinal and choroidal flow void areas and retinochoroidal shunt vessel on SS-OCTA; and central hypofluorescence with ...

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    11. Clinical study to estimate correlation between graft thickness as measured by anterior segment Optical Coherence Tomography and visual recovery after manual Descemet stripping endothelial keratoplasty

      Clinical study to estimate correlation between graft thickness as measured by anterior segment Optical Coherence Tomography and visual recovery after manual Descemet stripping endothelial keratoplasty

      Purpose: To estimate the correlation between graft thickness as measured by anterior segment Optical Coherence Tomography and visual recovery after manual Descemet stripping endothelial keratoplasty. Design: Prospective observational study. Materials and methods: This prospective observational study included 25 patients with pseudophakic bullous keratopathy, who underwent DSEK. Visual acuity in LogMAR units and estimation of graft thickness measured by Anterior Segment Optical Coherence Tomography (AS-OCT) was carried out on postoperative day 1, 3rd month and 6th month. Correlation analysis was performed between graft thickness and postoperative visual acuity on postoperative day 1, 3rd month and 6th month. Results: The mean LogMAR ...

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    12. AS-OCT of cyclitic membrane pre and post treatment with rtPA in the anterior chamber

      AS-OCT of cyclitic membrane pre and post treatment with rtPA in the anterior chamber

      We present the case of a 40 - year - old male, who presented to the ophthalmology emergency department with pain and visual loss in his left eye 10 days after an intravitreal injection of a split medication. At the exploration, we found an intense corneal edema in the left eye with endothelial dusting and ciliary hyperemia. LE fundus was impracticable due to anterior chamber opacity. Because of the corneal edema, we performed an anterior segment optical coherence tomography (AS - OCT), vi sualizing a cyclitic membrane with pupillary block and inflammatory cells in the anterior chamber. There are different treatments to lyse ...

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    13. Intraoperative Optical Coherence Tomography in Idiopathic Macular Epiretinal Membrane Surgery

      Intraoperative Optical Coherence Tomography in Idiopathic Macular Epiretinal Membrane Surgery

      Objective: To evaluate the feasibility and practicability of intraoperative optical coherence tomography (IOCT) in the surgery of idiopathic macular epiretinal membrane (IMM) without internal limiting membrane staining in all patients. Methods: Patients were selected from July 2018 to June 2020, and 32 patients (32 eyes) with IMM were operated with the use of IOCT. All patients underwent standard 23g vitrectomy. The internal limiting membrane was peeled off if there were obvious retinal folds. Intraoperative and postoperative complications, macular microstructural changes, and integrity of the detached membranes were recorded. The preoperative and postoperative best corrected visual acuity were compared. Results: The ...

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    14. Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives

      Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives

      When it first appeared, multimodal fundus imaging revolutionized the diagnostic workup and provided extremely useful new insights into the pathogenesis of fundus diseases. The recent addition of quantitative approaches has further expanded the amount of information that can be obtained. In spite of the growing interest in advanced quantitative metrics, the scientific community has not reached a stable consensus on repeatable, standardized quantitative techniques to process and analyze the images. Furthermore, imaging artifacts may considerably affect the processing and interpretation of quantitative data, potentially affecting their reliability. The aim of this survey is to provide a comprehensive summary of the ...

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    15. Intra-Operative Mounted Optical Coherence Tomography Findings Following Reversal of Optic Nerve Head Cupping in Childhood Glaucoma

      Intra-Operative Mounted Optical Coherence Tomography Findings Following Reversal of Optic Nerve Head Cupping in Childhood Glaucoma

      Purpose To examine the structural changes occurring in the optic nerve head (ONH) and macula in infants with childhood glaucoma and clinically observed ONH cupping reversal following intraocular pressure (IOP)-reducing glaucoma surgery, as captured by intra-operative spectral-domain optical coherence tomography (SD-OCT). Design Retrospective observational case series from an ongoing prospective cohort study. Methods Included were 18 eyes of 14 patients with childhood glaucoma. All eyes had SD-OCT imaging pre- and post-glaucoma intervention and clinically identified ONH cupping reversal. Patients with poor quality images or persistent optic nerve swelling following IOP reduction were excluded. Outcome measurements included IOP, cup-to-disc ratio ...

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      Mentions: Duke University
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  4. Picture Gallery

    3D-printed fiber-based zeroth- and high-order Bessel beam generator Postdoctoral Research Position Opening in  Intravascular Imaging at University of California, Davis Pairing imaging, AI may improve colon cancer screening, diagnosis 66% of diagnostic biopsies for common skin cancer can be avoided using Michelson Diagnostics' VivoSight OCT laser scanner Senior Scientist Opening at Topcon Healthcare Efficacy of Artificial Intelligence-Assisted Discrimination of Oral Cancerous Lesions from Normal Mucosa Based on the Oral Mucosal Image: A Systematic Review and Meta-Analysis Investigation of craquelure patterns in oil paintings using precise 3D morphological analysis for art authentication Algorithm Scientist Open Position at Optovue OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study Nondestructive in situ monitoring of pea seeds germination using optical coherence tomography Subcellular Comparison of Visible-Light Optical Coherence Tomography and Electron Microscopy in the Mouse Outer Retina Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu