1. Featured Articles

    1. What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021

      Explore Optical Coherence Tomography News Otolaryngology
      What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021

      This free, live event will take place on October 6 th, 10 EDT (4 PM CET) and will include an interactive Q&A session. For information and to register please visit this link. After the event a recorded version will be available at www.thorlabs.com/webinars . Abstract: Drs. Elizabeth Olson and Elliott Strimbu from Columbia University will highlight Phase Sensitive Spectral Domain Optical Coherence Tomography as it relates to nanoscale vibrometry. They will cover in detail the performance parameters of a Thorlabs Telesto for nanoscale displacement measurements in the cochlea and leverage their years of experience in the field ...

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      Mentions: Thorlabs Columbia University

    2. New Ultra-fast Digitizers gets a boost with peer-to-peer streaming

      Explore go.teledynelecroy.com Other Business News
      New Ultra-fast Digitizers gets a boost with peer-to-peer streaming

      Anyone working in experimental science or with high-end sampling applications at the limits of modern ultra-fast digitizers will soon realize the performance benefits to be gained from peer-to-peer (P2P) streaming. Rather than data being arbitrated between the host and its local memory, P2P streaming side-tracks the host enabling direct data transfers between expansion cards in modern PC backplanes. In this white paper, we explore the pitfalls of PCIe data transfer – how maximum throughput is impacted by host architecture, protocol coding, and payload size. 

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      Mentions: Teledyne SP Devices

    3. Luneau Technology Group merges with Optovue

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Luneau Technology Group merges with Optovue

      Luneau Technology Group announced that its merger with Optovue Inc. will enable the two companies to offer a comprehensive portfolio of health solutions to eye care providers. “We’re two agile companies with a startup mentality of innovation and flexibility,” Marc Abitbol, PhD, CEO of the newly merged company, said in a press release. “Together, we now have a full pipeline that covers everything for visual health. Optovue’s OCT expertise, stellar reputation and primary position in the medical eye care market and complementary portfolio of products make us an ideal partner, so our combined company can offer complete end-to-end ...

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      Mentions: Optovue

    4. Several Open Positions at the ZEISS Lab @ Medical University of Vienna

      Explore Optical Coherence Tomography News Jobs & Studentships
      Several Open Positions at the ZEISS Lab @ Medical University of Vienna

      The ZEISS Lab is a joint research initiative between the Medical University of Vienna and ZEISS. As an expansion of a successful, over 30 ‑ year ‑ long collaboration, it was established in 2018. With a focus on ophthalmology and surgical microscopy, we are investigating technologies that hold the potential to disrupt the way medicine is practiced. To grow and strengthen our team, we are currently seeking highly talented students and postdocs. We offer cutting-edge research projects at the interface between industry and academia as well as deep involvement in the innovation process of a leading medical device company. You can expect ...

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      Mentions: Medical University of Vienna Carl Zeiss Meditec

    5. Millimeter-scale chip–based supercontinuum generation for optical coherence tomography

      Explore Science Broadband Sources
      Millimeter-scale chip–based supercontinuum generation for optical coherence tomography

      Supercontinuum sources for optical coherence tomography (OCT) have raised great interest as they provide broad bandwidth to enable high resolution and high power to improve imaging sensitivity. Commercial fiber-based supercontinuum systems require high pump powers to generate broad bandwidth and customized optical filters to shape/attenuate the spectra. They also have limited sensitivity and depth performance. We introduce a supercontinuum platform based on a 1-mm 2 Si 3 N 4 photonic chip for OCT. We directly pump and efficiently generate supercontinuum near 1300 nm without any postfiltering. With a 25-pJ pump pulse, we generate a broadband spectrum with a flat ...

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      Mentions: Columbia University

    6. Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

      Explore bioRxiv.org Neurology
      Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2'-thiodiethanol (TDE) immersion on the improvement of PS-OCT measurements in ex vivo human brain tissue. We obtain the cortical fiber orientation maps in the gray matter, which reveals the radial fibers in the ...

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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University

    7. Take OCT to the Next Level

      Explore reviewofoptometry.com Ophthalmology
      Take OCT to the Next Level

      Mo re and more optometrists are investing in optical coherence tomography (OCT) for their practices. With the increase in adoption of this technology comes the question of how to expand its uses from conventional and common to sophisticated but still practical. This article looks to explore a few ways ODs can ramp up their OCT usage. OCT-A in Diabetic Retinopathy OCT angiography (OCT-A) is a noninvasive, dyeless imaging technology that provides volumetric maps of the retinal and choroidal vascular systems, as well as information on blood flow. Because it employs OCT imaging technology, vascular information can be viewed alongside or ...

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    8. Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign

      The Biophotonics Imaging Laboratory at the Beckman Institute for Advanced Science and Technology on the campus of the University of Illinois Urbana-Champaign has immediate openings for a post-doctoral research associate and a graduate student in the area of otologic (ear) imaging using optical coherence tomography (OCT). Headed by Prof. Stephen Boppart, the Biophotonics Imaging Laboratory is a dynamic and productive interdisciplinary research and training environment focused on developing novel optical biomedical imaging technologies, translating them into clinical applications, and driving them toward commercialization for improving healthcare. 

      Successful candidates are expected to have a strong experimental research background in OCT hardware ...

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      Mentions: University of Illinois at Urbana-Champaign

    9. Two Postdoc Openings at the Physical Optics and Biophotonics Group at Institute of Physical Chemistry, Warsaw, Poland

      Explore Optical Coherence Tomography News Jobs & Studentships
      Two Postdoc Openings at the Physical Optics and Biophotonics Group at Institute of Physical Chemistry, Warsaw, Poland

      This project aims to introduce and experimentally verify the authors' original description of physical processes related to the influence of light with partial spatial coherence on image reconstruction in the presence of optical heterogeneity. The proposed research works will allow for a better understanding of physical and technical limitations for imaging with partially spatially coherent light in systems with phase-sensitive (interferometric or holographic) detection. In this fundamental research program, we would like to solve one of the most basic problems of optics, which is in-vivo microscopic imaging in biological samples. This project aims to broaden our knowledge about the image ...

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    10. Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast

      Explore OSA | OSA Publishing
      Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast

      Volumetric imaging of dynamic processes with microscopic resolution holds a huge potential in biomedical research and clinical diagnosis. Using supercontinuum light sources and high numerical aperture (NA) objectives, optical coherence tomography (OCT) achieves microscopic resolution and is well suited for imaging cellular and subcellular structures of biological tissues. Currently, the imaging speed of microscopic OCT (mOCT) is limited by the line-scan rate of the spectrometer camera and ranges from 30 to 250 kHz. This is not fast enough for volumetric imaging of dynamic processes in vivo and limits endoscopic application. Using a novel CMOS camera, we demonstrate fast 3-dimensional OCT ...

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      Mentions: University of Lübeck

    11. Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Explore Nature Publishing Group Otolaryngology
      Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear's ...

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      Mentions: Massachusetts General Hospital Stanford University Harvard University

    12. Toth Receives 26th Annual Gertrude D. Pyron Award

      Explore Duke Ophthalmology Programs Ophthalmology
      Toth Receives 26th Annual Gertrude D. Pyron Award

      This year, the Retina Research Foundation's Gertrude D. Pyron Award is being presented to Cynthia A. Toth, MD , the Joseph A.C. Wadsworth Professor of Ophthalmology at Duke University School of Medicine and professor in the Department of Biomedical Engineering at Duke University’s Pratt School of Engineering. Dr. Toth is also vice chair of clinical research and director of physician-scientist development for Duke Eye Center. The Pyron Award was created by the Retina Research Foundation of Houston, Texas, to recognize outstanding vision scientists whose work contributes to knowledge about vitreoretinal disease. Its $50,000 cash prize includes a ...

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      Mentions: National Institutes of Health Duke University FDA

    13. Head-to-head comparison of quantitative measurements between intravascular imaging systems: An in vitro phantom study

      Explore ScienceDirect Cardiology
      Head-to-head comparison of quantitative measurements between intravascular imaging systems: An in vitro phantom study

      Introduction The present study aimed to compare the accuracy of quantitative measurements by contemporary intravascular imaging systems including optical frequency domain imaging (OFDI), frequency domain optical coherence tomography (FD-OCT), and 6 intravascular ultrasound (IVUS) systems. Methods We imaged five cylindrical phantom models made from an acrylic resin with known lumen diameters (1.51, 2.03, 3.04, 4.04, and 5.04 mm, respectively) using OFDI (FastView and LUNAWAVE, Terumo), FD-OCT (Dragonfly JP and ILUMIEN OPTIS, Abbott Vascular), and 6 mechanically rotating IVUS systems including a system, two 40-MHz, one 45-MHz, two 60-Mhz and one broad-band frequency IVUS systems. The ...

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      Mentions: Terumo Corporation Stanford University Abbott

    14. High-resolution mid-infrared optical coherence tomography with kHz line rate

      Explore OSA | OSA Publishing
      High-resolution mid-infrared optical coherence tomography with kHz line rate

      We report on mid-infrared optical coherence tomography (OCT) at 4 µm based on collinear sum-frequency upconversion and promote the A-scan scan rate to 3 kHz. We demonstrate the increased imaging speed for two spectral realizations, one providing an axial resolution of 8.6 µm, and one providing a record axial resolution of 5.8 µm. Image performance is evaluated by sub-surface micro-mapping of a plastic glove and real-time monitoring of C O 2 CO2 in parallel with OCT imaging.

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      Mentions: Technical University of Denmark (DTU) NKT Photonics

    15. MEMS-VCSEL as a tunable light source for OCT imaging of long working distance

      Explore SPIE Digital Library Tunable Sources
      MEMS-VCSEL as a tunable light source for OCT imaging of long working distance

      We present a wavelength tunable vertical-cavity surface-emitting laser (VCSEL) constructed by die-bonding a half-cavity InGaAs laser diode (LD) chip onto a silicon-on-insulator chip with a microelectromechanical system electrostatic diaphragm mirror that functions as a Fabry–Perot interferometer. As a result of the short cavity length, the integrated tunable LD has single-mode lasing characteristics with an extremely large coherence length of 150 m or more. The developed wavelength tunable LD is used to perform swept-source optical coherence tomography with a large scan depth, which is applicable to ophthalmic observation for the diagnosis of pathologic nearsightedness based on the measurement of the ...

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      Mentions: Santec

    16. Munch and optical coherence tomography: unravelling historical and artist applied varnish layers in painting collections

      Explore Home - Springer Art
      Munch and optical coherence tomography: unravelling historical and artist applied varnish layers in painting collections

      Effective care of large-scale museum collections requires planning that includes the conservation treatment of specific groups of art works, such as appropriate cleaning strategies. Optical coherence tomography (OCT) has been successfully applied as a non-invasive method for the stratigraphic visualisation of the uppermost transparent and semi-transparent layers in paintings, such as varnishes. Several OCT case study examples have further demonstrated the capabilities of the non-contact interferometric technique to measure the thickness of the various varnish layers, to help monitor cleaning and associated optical changes, and to detect past restorations. OCT was applied for the detection of varnishes to 13 paintings ...

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      Mentions: Nicolaus Copernicus University

    17. Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma

      Explore ScienceDirect Pulmonology
      Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma

      Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. 1 Patients with severe asthma may benefit from bronchial thermoplasty (BT), an endoscopic treatment that targets structural AR and induces ASM reduction. 2 Assessment of AR is critical to evaluate the impact of BT and might provide a tool for patient selection for BT. Polarization sensitive optical coherence tomography (PS-OCT) imaging has been proposed as a minimally invasive diagnostic method to assess ASM mass as an alternative to focal airway biopsies. Bronchoscopic standard optical coherence ...

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      Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam

    18. Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Explore Optical Coherence Tomography News Other Business News
      Wasatch Photonics announces the appointment of Neil Anderson as Vice President, Gratings and OCT

      Wasatch Photonics is pleased to announce and welcome Neil Anderson, Ph.D. as the new Vice President of Gratings and OCT. In this role, Neil will be responsible for commercial leadership and growth of the company’s transmission gratings and optical coherence tomography business, working with the teams in Logan, UT, and Morrisville, NC, to develop innovative product solutions matched to current and emerging market needs in laser pulse compression, optical coherence tomography (OCT), astronomy, and photonics. Neil is a well-known and respected figure in the optics and photonics industry and brings 15 years of experience supporting customers with optical ...

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      Mentions: Wasatch Photonics

    19. A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

      Explore ScienceDirect
      A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

      The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to ...

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      Mentions: University of Kent Chinese Academy of Sciences

    20. Ophthalmic Systems Architect at Zeiss

      Explore Optical Coherence Tomography News Jobs & Studentships
      Ophthalmic Systems Architect at Zeiss

      JOB SUMMARY: The Ophthalmic Systems Architect is responsible for driving systems architecture design, trade-off analysis, implementation, and validation across cloud-ready ophthalmic diagnostics products. This role collaborates with various functions within ZEISS to define systems requirements for performance, cost, manufacturability, serviceability, and reliability from hardware through software and user experience. The Ophthalmic Systems Architect works from concept phase through commercial launch to ensure meeting customer needs and exceeding their expectations. Deep passion and experience in developing consumer products from prototyping through productization is crucial for success in this role. ESSENTIAL FUNCTIONS: (Responsibilities that are central to the job and MUST be ...

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      Mentions: Carl Zeiss Meditec
    21. See all articles

  2. Recent Articles From Around The Web

    1. Vascular and Structural Alterations of the Choroid Evaluated by Optical Coherence Tomography Angiography and Enhanced-Depth Imaging Optical Coherence Tomography in Eyes with Reticular Pseudodrusen and Soft Drusen

      Explore ScienceDirect Ophthalmology
      Vascular and Structural Alterations of the Choroid Evaluated by Optical Coherence Tomography Angiography and Enhanced-Depth Imaging Optical Coherence Tomography in Eyes with Reticular Pseudodrusen and Soft Drusen

      Background To assess the vascularity of choriocapillaris and structural choroidal differences in eyes with reticular pseudodrusen (RPD) and soft drusen. Methods 21 eyes with RPD (group 1), 17 eyes with soft drusen (group 2), and 19 eyes as a control group (group 3) were included in this study. Choriocapillaris vascular density and flow area were measured by optical coherence tomography angiography. Total choroidal area, luminal area, stromal area, and lumen/stroma ratios were measured on optical coherence tomography B-scans converted to binary images. Results Mean choriocapillaris vascular density was higher in group 3 than other groups (group 1 vs 3 ...

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    2. Total venous nature of retinal deep capillary plexus inferred by continuity of prominent middle limiting membrane sign in optical coherence tomography

      Explore Journals | PLOS Ophthalmology
      Total venous nature of retinal deep capillary plexus inferred by continuity of prominent middle limiting membrane sign in optical coherence tomography

      This study aimed to theoretically identify the vascular nature of the deep capillary plexus (DCP) by examining patients presenting with both paracentral acute middle maculopathy (PAMM) and prominent middle limiting membrane (p-MLM) sign and p-MLM sign alone in spectral-domain optical coherence tomography (SD-OCT). A retrospective review of the medical records of patients with retinal vein or artery occlusion from two tertiary medical centers was performed. Consecutive patients with a clinical diagnosis of all categories of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) (branch or central and ischemic or non-ischemic) who had undergone SD-OCT imaging from January 2015 to ...

      Read Full Article

    3. Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography

      Explore jcadonline.com Dermatology
      Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography

      Background. Onychomycosis affects 43 million people in the United States and Europe. Topical therapies can be effective but require lengthy and costly regimens without an established method for predicting the treatment outcome. Objective. We studied the role of optical coherence tomography (OCT), a noninvasive imaging device approved by the United States Food and Drug Administration, in evaluating onychomycosis treatment outcomes. Methods. This investigator-initiated prospective clinical study recruited subjects from two urban medical centers. A total of 34 subjects with mild-to-moderate onychomycosis, confirmed using periodic acid-Schiff (PAS) staining, were treated with topical efinaconazole for 48 weeks, at which time a final ...

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      Mentions: Mount Sinai School of Medicine

    4. Accuracy of Common Motion Estimators in Wave-Based Optical Coherence Elastography

      Explore jbpe.ssau.ru
      Accuracy of Common Motion Estimators in Wave-Based Optical Coherence Elastography

      Abstract. Motion estimators are commonly used in shear wave optical coherence elastography to compute small displacements. This work focuses on comparing three motion estimators: Kasai, Loupas, and the vector method. Our results show that the vector method is superi or in low - SNR, low - amplitude situations for group velocity calculation and profile reconstruction . © 202 1 Journal of Biomedical Photonics & Engineering.

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      Mentions: University of Houston

    5. Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy

      Explore OSA | OSA Publishing Developmental Biology
      Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy

      Dynamic full-field optical coherence microscopy (DFFOCM) was used to characterize the intracellular dynamic activities and cytoskeleton of HeLa cells in different viability states. HeLa cell samples were continuously monitored for 24 hours and compared with histological examination to confirm the cell viability states. The averaged mean frequency and magnitude observed in healthy cells were 4.79±0.5 Hz and 2.44±1.06, respectively. In dead cells, the averaged mean frequency was shifted to 8.57±0.71 Hz, whereas the magnitude was significantly decreased to 0.53±0.25. This cell dynamic activity analysis using DFFOCM is expected ...

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      Mentions: National Institutes of Health

    6. A New Method for Automating the Diagnostic Analysis of Human Fundus Images Obtained Using Optical Coherent Tomography Angiography

      Explore Home - Springer Ophthalmology
      A New Method for Automating the Diagnostic Analysis of Human Fundus Images Obtained Using Optical Coherent Tomography Angiography

      This article presents the results of the joint work of image analysis specialists and ophthalmologists on the problem of analyzing images obtained by optical coherence tomography (angiography). A descriptive algorithmic scheme for analyzing images obtained using optical coherence tomography angiography was constructed to automate detection of pathological changes in the morphometric characteristics of the fundus. The algorithmic scheme is based on the image processing, analysis, and recognition methods. A feature space has been developed that makes it possible to identify pathological changes in the structure of the vascular plexuses of the human retina. It was possible to achieve high-accuracy classification ...

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    7. Quantifying Retinal Microvascular Morphology in Schizophrenia Using Swept-Source Optical Coherence Tomography Angiography

      Explore Journals Neurology , Ophthalmology
      Quantifying Retinal Microvascular Morphology in Schizophrenia Using Swept-Source Optical Coherence Tomography Angiography

      Background: Retinovascular changes are reported on fundus imaging in schizophrenia (SZ). This is the first study to use swept-source optical coherence tomography angiography (OCT-A) to comprehensively examine retinal microvascular changes in SZ. Methods: This study included 30 patients with SZ/schizoaffective disorder (8 early and 15 chronic) and 22 healthy controls (HCs). All assessments were performed at Beth Israel Deaconess Medical Center and Massachusetts Eye and Ear. All participants underwent swept-source OCT-A of right (oculus dextrus [OD]) and left (oculus sinister [OS]) eye, clinical, and cognitive assessments. Macular OCT-A images (6 × 6 mm) were collected with the DRI Topcon Triton ...

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      Mentions: Beth Israel Deaconess Medical Center Topcon Medical Systems

    8. In vivo examination of healthy human skin after short-time treatment with moisturizers using confocal Raman spectroscopy and optical coherence tomography: Preliminary observations

      Explore Wiley Online Library Dermatology
      In vivo examination of healthy human skin after short-time treatment with moisturizers using confocal Raman spectroscopy and optical coherence tomography: Preliminary observations

      Skin is our barrier against environmental damage. Moisturizers are widely used to increase hydration and barrier integrity of the skin; however, there are contrasting observations on their in vivo effects in real-life settings. In cosmetic studies, corneometers and tewameters are traditionally used to assess skin hydration. In this study, two novel noninvasive diagnostic techniques, optical coherence tomography (OCT) and confocal Raman spectroscopy, were used to analyze stratum corneum and epidermal thickness (ET), water content, blood flow in function of depth, skin roughness, attenuation coefficient, natural moisturizing factor, ceramides and free fatty acids, cholesterol, urea, and lactates in 20 female subjects ...

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      Mentions: Ludwig Maximilian University of Munich

    9. Human Foveal Cone and Müller Cells Examined by Adaptive Optics Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      Human Foveal Cone and Müller Cells Examined by Adaptive Optics Optical Coherence Tomography

      Purpose: The purpose of this study was to image and investigate the foveal microstructure of human cone and Müller cells using adaptive optics-optical coherence tomography. Methods: Six healthy subjects underwent the prototype adaptive optics-optical coherence tomography imaging, which allowed an axial resolution of 3.4 µm and a transverse resolution of approximately 3 µm. The morphological features of the individual retinal cells observed in the foveola were qualitatively and quantitatively evaluated. Results: In the six healthy subjects, the image B-scans showed hyper-reflective dots that were densely packed in the outer nuclear layer. The mean number, diameter, and density of ...

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      Mentions: Kyoto University Graduate School of Medicine

    10. Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      Explore American Journal of Ophthalmology Ophthalmology
      Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      We read with interest the manuscript by Bansal and associates 1 regarding optical coherence tomography (OCT) to assess retinal reattachment following successful pneumatic retinopexy (PnR). The authors propose that retinal reattachment occurs through 5 specific stages: approach of the neurosensory retina towards the retinal pigment epithelium (RPE, stage 1), improvement of outer retinal corrugations (stage 2), contact of the neurosensory retina to the RPE (stage 3), deturgescence of the photoreceptors (stage 4) and recovery of photoreceptor integrity (stage 5). An incomplete resolution of outer retinal corrugations before retinal reattachment may lead, according to the authors, to the formation of outer ...

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    11. Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

      Explore bioRxiv.org Neurology
      Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

      The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic centimeters of ex vivo human cerebellum tissue using as-PSOCT. The morphometric and optical properties of the cerebellar cortex across five subjects were quantified. While the molecular and granular layers exhibited ...

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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Harvard University

    12. Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Explore American Journal of Ophthalmology Ophthalmology
      Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Purpose To evaluate the ocular and systemic determinants of the choriocapillaris flow deficits percentage (CC FD%) in normal eyes. Design Observational cross-sectional study. Methods Healthy Chinese participants without ocular or systemic diseases underwent detailed ophthalmic evaluations, including swept-source optical coherence tomography angiography (SS-OCTA) with 6 × 6 mm macular choriocapillaris images. The CC FD% was assessed in circular regions with diameters of 1.0 and 5.0 mm, rings with 1.0–2.5-mm and 2.5–5.0-mm diameters. Results The study included 830 individuals (mean age: 58.66±8.75 years). CC FD% (mean: 22.05%±1.13%) was ...

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      Mentions: Topcon Medical Systems Sun Yat-Sen University Haag-Streit

    13. Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Explore American Journal of Ophthalmology Ophthalmology
      Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Purpose To develop deep learning models for identification of sex and age from macular optical coherence tomography (OCT), and to analyze the features for differentiation of sex and age. Design Algorithm development using database of macular OCT. Setting One eye center in Taiwan. Study Population 6147 sets of macular optical coherence tomography (OCT) images from the healthy eyes of 3134 persons. Main Outcome Measures Deep learning based algorithms were used to develop models for identification of sex and age, and 10-fold cross-validation was applied. Gradient-weighted class activation mapping (Grad-CAM) was used for feature analysis. Results The accuracy for sex prediction ...

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    15. Estimation of scleral mechanical properties from air-puff optical coherence tomography

      Explore OSA | OSA Publishing
      Estimation of scleral mechanical properties from air-puff optical coherence tomography

      We introduce a method to estimate the biomechanical properties of the porcine sclera in intact eye globes ex vivo , using optical coherence tomography that is coupled with an air-puff excitation source, and inverse optimization techniques based on finite element modeling. Air-puff induced tissue deformation was determined at seven different locations on the ocular globe, and the maximum apex deformation, the deformation velocity, and the arc-length during deformation were quantified. In the sclera, the experimental maximum deformation amplitude and the corresponding arc length were dependent on the location of air-puff excitation. The normalized temporal deformation profile of the sclera was distinct ...

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      Mentions: University of Rochester Spanish National Research Council
      16. See all articles
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    1. (4 articles) Harvard University
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    3. (4 articles) Ludwig Maximilian University of Munich
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    1. (3 articles) Optovue
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  8. Picture Gallery

    What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021 New Ultra-fast Digitizers gets a boost with peer-to-peer streaming Luneau Technology Group merges with Optovue Several Open Positions at the ZEISS Lab @ Medical University of Vienna Millimeter-scale chip–based supercontinuum generation for optical coherence tomography Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue Take OCT to the Next Level Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign Two Postdoc Openings at the Physical Optics and Biophotonics Group at Institute of Physical Chemistry, Warsaw, Poland Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter Toth Receives 26th Annual Gertrude D. Pyron Award

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    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu