1. Recent Articles From Around The Web

    1. Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions

      Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions

      The aim of this study was to evaluate retinal and choriocapillaris vessel density using optical coherence tomography angiography (OCTA) in eyes with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) complicated by macular edema (ME). Sixty eyes of 60 patients with CRVO or BRVO and ME and 40 healthy subjects underwent measurements of superficial and deep foveal and parafoveal vessel density (FVD, PFVD) and choricapillary density using OCTA at baseline and 60 days after intravitreal dexamethasone implant (IVDEX). FVD and PFVD of the superficial plexus were not significantly lower in CRVO group compared to the controls while ...

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    2. Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography

      Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography

      Importance The evaluation of anterior chamber scan (ACS) of Cirrus optical coherence tomography (OCT) for routine clinical use Background To assess the variability of anterior chamber angle (ACA) measurements using the ACS Design Cross-sectional observational study Participants Forty subjects aged 40-80 years Methods One randomly selected eye from 40 subjects was imaged with Cirrus OCT (model 5000, Carl Zeiss Meditec, Dublin, CA) by two different operators (expert vs non-expert) with a 15-minute interval for inter- and intra-observer variability of image acquisition. For image grading, the angle opening distance (AOD750) and the trabecular iris space area (TISA750) of nasal and temporal ...

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    3. OCT angiography offers dual advantage of imaging structure, blood flow

      OCT angiography offers dual advantage of imaging structure, blood flow

      tate-of-the-art of optical coherence tomography angiography in 2017 is for diagnosis and management of neovascularization, according to a speaker here. “It’s a single device, two modalities,” Jay S. Duker, MD , said at Retina 2017. “And once you get over the initial cost of buying OCTA, there’s really not a lot of added cost. It’s a few seconds of chair time per eye.” Jay S. Duker OCT angiography allows clinicians to view both the structure and blood flow of the retinal and choroidal tissue simultaneously via three-dimensional angiograms, providing a tool for diagnosing neovascularization and other abnormalities. It ...

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    4. Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      PURPOSE: To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles. . METHODS: Seventy eyes from 35 healthy patients were studied. Three OCT instruments—Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)—were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles. The intraclass correlation coefficient (ICC) was calculated to determine the reproducibility and the agreement between the three ...

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    5. Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      There has been increasing attention on neoatherosclerosis in coronary arteries following implantation of bare-metal and drug-eluting stents.1,2 Neoatherosclerosis might be a concern even in the field of peripheral artery disease (PAD). A 75-year-old man with hypertension, diabetes mellitus, dyslipidemia and a history of right iliac artery stenting with a Wallstent 12 years previously, was referred to hospital for treatment of recurrent/progressive intermittent claudication (Rutherford category 3) that had started 6 months earlier. Ankle brachial index (ABI) was 0.51 on the right. Diagnostic angiography showed significant in-stent restenosis in the right iliac artery stent (Figure A). Intravascular ...

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    6. Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

      Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

      Background The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. OCTA images were analyzed for alterations in retinochoroidal microvasculature. Results Thirty-four eyes (24 patients; 10 with VKH and 14 with CSC) were included. OCTA en face images showed apparent areas of choriocapillaris flow void due to shadowing effect from ...

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      Mentions: Vishali Gupta
    7. Waheed gives four steps for detecting CNV with OCT angiography

      Waheed gives four steps for detecting CNV with OCT angiography

      Even though fluorescein angiography plus high-resolution optical coherence tomography is the gold standard for detecting neovascularization, OCT angiography does a better job than FA in some situations, Nadia K. Waheed , MD, said at Retina 2017. However, interpreting the OCT angiography findings can be time consuming, with the reader needing sometimes to scroll through entire data sets. In cases of suspected choroidal neovascularization, Waheed offered guidance to help OCT angiography users interpret the data. First, she said, make sure to look at the right spot using the 3 by 3 scan to provide the highest resolution. “The second step that I ...

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    8. Automated assessment of glaucoma loss from optical coherence tomography

      Automated assessment of glaucoma loss from optical coherence tomography

      Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.

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    9. High visibility endoprosthesis and method

      High visibility endoprosthesis and method

      An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.

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    10. Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

      Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

      Importance Correct attribution of vascular features in optical coherence tomography (OCT) angiography depends on accurate segmentation of retinal layers. Objective To evaluate the segmentation of retinal layers among 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular plexuses terminate. Design, Setting, and Participants A retrospective review of a representative OCT angiogram from 1 patient and an evaluation of the vascular pattern in an autopsied eye were conducted at a community retina practice at a university laboratory. A set of 3 × 3-mm scans centered on the fovea using the Cirrus 5000, RTVue XR Avanti ...

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    11. OCT Study of the Femtosecond Laser Opaque Bubble Layer

      OCT Study of the Femtosecond Laser Opaque Bubble Layer

      PURPOSE: To characterize the location and regularity of the opaque bubble layer (OBL) in the corneal stroma after femtosecond laser-assisted LASIK (FS-LASIK) flap generation. METHODS: In this prospective study, 30 eyes of 15 patients who had FS-LASIK surgery for myopia, astigmatism, and/or hyperopia were included. Screen captures were obtained at the end of the flap creation and the eyes with hard type OBL were immediately imaged with anterior segment optical coherence tomography. RESULTS: The mean age of the 9 men and 6 women was 40 ± 11.3 years (range: 22 to 60 years). Seven eyes (23.3%) developed hard ...

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      Mentions: Cleveland Clinic
    12. The role of optical coherence tomography in Alzheimer’s disease

      The role of optical coherence tomography in Alzheimer’s disease

      Background Alzheimer’s disease (AD) is the most common cause of dementia and its incidence is increasing worldwide along with population aging. Previous clinical and histologic studies suggest that the neurodegenerative process, which affects the brain, may also affect the retina of AD patients. Main body Optical coherence tomography (OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Several previous studies demonstrated that both peripapillary retinal nerve fiber layer and macular thickness measurements assessed by OCT were able to detect neuronal loss in AD. Moreover, recent advances in OCT technology, have allowed ...

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    13. The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

      The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

      Background Biomarker”, a merged word of “biological marker”, refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases. Main body Spectral domain optical coherence tomography imaging-based biomarkers provide a valuable tool for detecting the earlier stages of the disease, tracking progression, and ...

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      Mentions: Sandeep Saxena
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  2. Organizations in the News

    1. (3 articles) Tufts University
    2. (2 articles) Center for Ophthalmic Optics and Lasers
    3. (2 articles) University of Kent
    4. (2 articles) Oregon Health & Science University
    5. (1 articles) Centre Hospitalier Intercommunal de Créteil
    6. (1 articles) National University of Singapore
    7. (1 articles) National Institutes of Health
    8. (1 articles) Singapore Eye Research Institute
    9. (1 articles) Kobe University Graduate School of Medicine
    10. (1 articles) Imperial College London
  3. People in the News

    1. (2 articles) David Huang
    2. (2 articles) Adrian G. Podoleanu
    3. (1 articles) Robert A. Huber
    4. (1 articles) Adrian Bradu
    5. (1 articles) Thomas Klein
    6. (1 articles) Richard F. Spaide
    7. (1 articles) Milan Sonka
    8. (1 articles) Gangjun Liu
    9. (1 articles) Hiromasa Otake
    10. (1 articles) Ramona Cernat
    11. (1 articles) Pearse A. Keane
    12. (1 articles) Yali Jia
    13. (1 articles) Sandeep Saxena
    14. (1 articles) Nadia K. Waheed
    15. (1 articles) Michael D. Abràmoff
  4. OCT Companies in the News

    1. (5 articles) Carl Zeiss Meditec
    2. (2 articles) Topcon Medical Systems
    3. (1 articles) Optovue
    4. (1 articles) St. Jude Medical
    5. (1 articles) NinePoint Medical
    6. (1 articles) Heidelberg Engineering
  5. Picture Gallery

    Research Assistant/Associate in Biophotonics and Endoscopic Imaging at Imperial College London High-speed OCT light sources and systems Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography Two from MIT share National Academy of Engineering Fritz J. and Dolores H. Russ Prize Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity Medical Imaging Innovator Christine Hendon Wins Presidential Honor Heidelberg Engineering and Gauss Medical Corporation Establish an Ophthalmic Healthcare IT Joint Venture in China The University of Houston Receives NIH Grant for Optical Coherence Tomography to Study Effect of Poly-Drug Exposure on Fetal Brain Development En face coherence microscopy SPIE 2017 awards honor biomedical, photonics achievements and dedication to education including Early Career Achievement Award in OCT To Utkarsh Sharma Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography
  6. Recent Quotes

    1. Our OCT Angiography congresses is a major force in promoting the transition from FA to OCTA by educating the ophthalmologists .
      By Bruno Lumbroso
    2. The development of OCT in the early 1990s greatly benefited from components and methods used in fiber-optical communications...And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    3. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    4. Our study demonstrates world-record results in cubic meter volume imaging, with at least an order of magnitude larger depth range and volume compared to previous demonstrations of three-dimensional OCT...These results provide a proof-of-principle demonstration for using OCT in this new regime...Long-range OCT is a new range of operation that requires extremely high performance light sources, integrated optical receivers and signal processing.
      By James G. Fujimoto
    5. Research by our group at MIT and our collaborators at Praevium Research and Thorlabs indicated that the coherence length of the VCSEL source was orders of magnitude longer than other swept laser technologies suitable for OCT, which suggested the possibility of long-range OCT imaging.
      By Benjamin M. Potsaid
    6. "The development of OCT in the early 1990s greatly benefited from components and methods used in fiber optical communications,. And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      By James G. Fujimoto
    7. OCT has revolutionized the treatment of eye disease on a global basis and it is now routinely used to make clinical decisions in treating patients with blinding eye diseases...I’ve been honored to be part of the team that created this technology and to know our creation has improved diagnosis and treatment for millions of eye patients around the world.
      By Carmen A. Puliafito
    8. We believe strongly that our MRO™ sub-dermal fingerprint technology can play a key role in addressing the presentation attack problem by providing an effective deployable solution.
      By Don Bogue
    9. Today, interdisciplinary research in biomedical optics is the standard. “And that was less common 25 years ago. A lot of innovation happens at the boundaries of disciplines. OCT is such a rich combination of disciplines—in optics, mechanical systems, electronics, software, medical devices, clinical medicine. That’s one of the reasons there’s been so much innovation in OCT, and that there’s so much more to come.
      By Eric A. Swanson
    10. We are excited to bring to market groundbreaking technologies that provide valuable new, detailed information about the microvasculature of the eye, in a manner that reduces the burden for both the patient and the clinic staff...DualTrac Motion Correction allows for improved imaging and quicker data collection to further the clinical utility of OCTA technology by accommodating natural eye movement.
      By Jay Wei