1. Recent Articles From Around The Web

    1. Imaging retinal structures at cellular-level resolution by visible-light optical coherence tomography

      Imaging retinal structures at cellular-level resolution by visible-light optical coherence tomography

      In vivo high-resolution images are the most direct way to understand retinal function and diseases. Here we report the use of visible-light optical coherence tomography with volumetric registration and averaging to achieve cellular-level retinal structural imaging in a rat eye, covering the entire depth of the retina. Vitreous fibers, nerve fiber bundles, and vasculature were clearly revealed, as well as at least three laminar sublayers in the inner plexiform layer. We also successfully visualized ganglion cell somas in the ganglion cell layer, cells in the inner nuclear layer, and photoreceptors in the outer nuclear layer and ellipsoid zone. This technique ...

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    2. Radial Artery Spiral Dissection Confirmed by OCT Without Guidewire Shadow

      Radial Artery Spiral Dissection Confirmed by OCT Without Guidewire Shadow

      A 75-year-old man underwent right transradial coronary angiography because of acute myocardial infarction. Postprocedural radial angiography revealed a dissection with a spiral luminal filling defect in the proximal radial artery corresponding to a National Heart, Lung, and Blood Institute type D dissection (Figure 1A; Video 1). In order to acquire a full, 360° optical coherence tomography (OCT) image, we withdrew the guidewire out of the sheath ahead of pullback and left the OCT imaging wire in the vessel alone. However, subsequent pullbacks were performed without any difficulties. Without the guidewire shadow, it was clear that the dissection started from a ...

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    3. Intraretinal Fluid Pattern Characterization in Optical Coherence Tomography Images

      Intraretinal Fluid Pattern Characterization in Optical Coherence Tomography Images

      Optical Coherence Tomography (OCT) has become a relevant image modality in the ophthalmological clinical practice, as it offers a detailed representation of the eye fundus. This medical imaging modality is currently one of the main means of identification and characterization of intraretinal cystoid regions, a crucial task in the diagnosis of exudative macular disease or macular edema, among the main causes of blindness in developed countries. This work presents an exhaustive analysis of intensity and texture-based descriptors for its identification and classification, using a complete set of 510 texture features, three state-of-the-art feature selection strategies, and seven representative classifier strategies ...

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    4. Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography

      Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography

      Aims: We sought to evaluate procedural complications and one-year clinical outcomes for patients who underwent percutaneous coronary intervention (PCI) with orbital (OA) and rotational atherectomy (RA). Methods and results: From a total of 13,467 patients who underwent PCI in our hospital between January 2013 and June 2016, 1,149 consecutive patients were treated with atherectomy for moderately-severely calcified lesions (184 with OA, 965 with RA). Procedural complications were similarly observed in the two groups except for higher dissection and perforation rates with OA. Major adverse cardiovascular events (MACE) were defined as the composite of death, myocardial infarction or target ...

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    5. Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

      Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

      Coronary artery vasospasm is an infrequent cause of acute coronary syndrome (ACS). A 50-year-old female developed persistent chest discomfort related to anterior STEMI. After an unsuccessful thrombolysis attempt, due to delay concern, the patient was then sent to the catheterization laboratory for rescue PCI. The coronary angiogram revealed a TIMI 3 flow proximal LAD significant stenosis with spastic appearance of the coronary arteries which has improved after intracoronary nitrates administration. Optical Coherence Tomography (OCT) excluded coronary artery dissection and haematoma also revealed thrombus on moderate atherosclerotic plaque. The patient was then pain-free; she was managed medically and discharged after few ...

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    6. OCT-A characterisation of recurrent type 3 macular neovascularisation

      OCT-A characterisation of recurrent type 3 macular neovascularisation

      Purpose To investigate optical coherence tomography angiography (OCT-A) findings in recurrent type 3 macular neovascularisation (MNV). Methods In this retrospective cohort study, consecutive patients with type 3 MNV secondary to age-related macular degeneration underwent OCT-A at three different time points: baseline, after anti-vascular endothelial growth factor treatment with complete resolution of the exudative signs (ie, non-exudative stage) and at the recurrence of exudation (ie, recurrence stage). Demographics and clinical findings were analysed, including OCT-A features of type 3 MNV recurrence. Results Twelve eyes (12 patients, mean age 78±7 years) were included. Using OCT-A, at baseline all type 3 MNVs ...

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    7. Quantitative Coronary Angiography Can Predict Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients

      Quantitative Coronary Angiography Can Predict Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients

      Purpose Cardiac allograft vasculopathy (CAV) is a leading cause of death and re-transplantation (tx). Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are increasingly used for earlier detection, but lengthen procedure time and cost, and are unsuitable in small children. Coronary angiography is routine in all age groups but may be subjectively interpreted. We hypothesized that serial analysis of quantitative coronary angiography (QCA) is possible in infants and children and may also predict disease progression. Methods Pediatric recipients between Feb 1999 - July 2012 were studied. QCA was performed in two projections of the same region of the right (RCA), left ...

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    8. “Virtual Biopsies” of Normal Skin and Thermal and Chemical Burn Wounds

      “Virtual Biopsies” of Normal Skin and Thermal and Chemical Burn Wounds

      The search for noninvasive methods to image and measure the mechanical properties of skin has been a frequent subject of research for many years. Although suction testing, elastography, and other testing can be noninvasive, these tests fail to yield comparable results to destructive tests such as uniaxial tensile testing. Accordingly, researchers have developed a technique to combine optical coherence tomography with vibrational analysis ( vibrational optical coherence tomography ) to image and analyze the biomechanical properties of tissues noninvasively and nondestructively. The result of this analysis is a “ virtual biopsy ” of skin , along with a physical analysis of the major components of ...

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    9. Dynamic optical coherence elastography (Thesis)

      Dynamic optical coherence elastography (Thesis)

      Dynamic optical coherence elastography (OCE) is a functional imaging modality which leverages the propagation of mechanical waves in order to estimate the mechanical properties of tissues. It is very useful since it does not require (i) a priori knowledge of force/stress, (ii) mandatory direct contact between the mechanical loading source and the tissue under study, and (iii) large deformation of tissues. Therefore, dynamic OCE shows promise for non-contact, in situ, and in vivo mechanical characterization of tissues with applications in laboratory and clinical studies. To date, the impact of using transient/continuous temporal excitation produced by one/multiple loading ...

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    10. The evaluation and correlation of subfoveal choroidal thickness and macular hole apical and basal diameters with enhanced depth imaging optical coherence tomography in patients with idiopathic macular hole

      The evaluation and correlation of subfoveal choroidal thickness and macular hole apical and basal diameters with enhanced depth imaging optical coherence tomography in patients with idiopathic macular hole

      Purpose: To investigate the evaluation and correlation between apical and basal hole diameters and subfoveal choroidal thickness (SCT) in patients with idiopathic macular hole (IMH), using enhanced depth imaging optical coherence tomography (OCT). Methods: This cross-sectional study included 30 eyes of 30 patients with IMH and 30 healthy controls eyes. The SCT of subjects were measured using enhanced depth imaging OCT and the results were compared. In the IMH group, the mean horizontal apical and basal diameters of IMH were calculated and the correlation between mean apical and basal diameters and SCT were investigated. All patients with IMH underwent vitreoretinal ...

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    11. In vivo imaging of human cornea with highspeed and high-resolution Fourier-domain full-field optical coherence tomography

      In vivo imaging of human cornea with highspeed and high-resolution Fourier-domain full-field optical coherence tomography

      : Corneal evaluation in ophthalmology necessitates cellular-resolution and fast imaging techniques allowing accurate diagnoses. Currently, the fastest volumetric imaging technique is Fourier-domain full-field optical coherence tomography (FD-FF-OCT) that uses a fast camera and a rapidly tunable laser source. Here, we demonstrate high-resolution, highspeed, non-contact corneal volumetric imaging in vivo with FD-FF-OCT that can acquire a single 3D volume with a voxel rate of 7.8 GHz. The spatial coherence of the laser source was suppressed to prevent it from focusing to a spot on the retina, and therefore, exceeding the maximum permissible exposure (MPE). Inherently volumetric nature of FD-FF-OCT data enabled ...

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    12. Accuracy of swept source optical coherence tomography and ultrasound biomicroscopy for evaluation of posterior lens capsule in traumatic cataract

      Accuracy of swept source optical coherence tomography and ultrasound biomicroscopy for evaluation of posterior lens capsule in traumatic cataract

      Purpose To assess the efficacy of swept source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM) in detecting posterior capsule (PC) defect in patients with traumatic cataract. Design Observational case-series Methods Sixty-seven eyes from 67 patients, without age limitation and with traumatic cataract severe enough to prevent slit lamp evaluation of the PC, included in a simple sequence without randomization. Patients underwent both 50 MHz UBM and SS-OCT evaluation of the PC by different operators. Then, cataract surgery was performed using a single technique. Results Sixty-seven eyes from 67 patients including 60 men and 7 women were studied. The mean ...

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    13. RAG-FW: A hybrid convolutional framework for the automated extraction of retinal lesions and lesion-influenced grading of human retinal pathology

      RAG-FW: A hybrid convolutional framework for the automated extraction of retinal lesions and lesion-influenced grading of human retinal pathology

      The identification of retinal lesions plays a vital role in accurately classifying and grading retinopathy. Many researchers have presented studies on optical coherence tomography (OCT) based retinal image analysis over the past. However, to the best of our knowledge, there is no framework yet available that can extract retinal lesions from multi-vendor OCT scans and utilize them for the intuitive severity grading of the human retina. To cater this lack, we propose a deep retinal analysis and grading framework (RAG-FW). RAG-FW is a hybrid convolutional framework that extracts multiple retinal lesions from OCT scans and utilizes them for lesion-influenced grading ...

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  2. Organizations in the News

    1. (2 articles) Medical University of Vienna
    2. (2 articles) Harbin Medical University
    3. (2 articles) University of Rochester
    4. (1 articles) Sungkyunkwan University
    5. (1 articles) Centre Hospitalier Intercommunal de Créteil
    6. (1 articles) Université Pierre et Marie Curie
    7. (1 articles) San Raffaele Scientfic Institute
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    9. (1 articles) Oregon Health & Science University
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  3. People in the News

    1. (2 articles) Francesco Bandello
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    5. (1 articles) Wolfgang Drexler
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    13. (1 articles) Angelika Unterhuber
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  4. OCT Companies in the News

    1. (1 articles) Optovue
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  5. Picture Gallery

    Spectroscopic optical coherence refraction tomography NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy Open Rank Tenure Track Faculty Position in Retina Research, University of Rochester, Rochester, NY NTU scientists develop handheld, high-resolution medical imaging device COMPARISON OF POST STENT OPTICAL COHERENCE TOMOGRAPHY FINDINGS AMONG THREE SUBTYPES OF CALCIFIED CULPRIT PLAQUES IN PATIENTS WITH ACUTE CORONARY SYNDROME Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast Novel Tunable Lasers for Optical Coherence Tomography: Marie Curie Early Stage Positions to train towards PhD in an European Innovative Training Network PhotoniCare Announces Nishant Mohan as their New Chief Technology and Product Officer ZEISS Medical Technology Announces Changes in Ophthalmic Devices Executive Leadership Optical Coherence Tomography Angiography of Idiopathic Foveal Hypoplasia and Its Correlation With Visual Acuity Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode Dual-band infrared optical coherence tomography using a single supercontinuum source
  6. Recent Quotes

    1. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    2. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    3. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    4. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    5. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen
    6. We hope that this new lab between SNEC-SERI and NTU will be the start of an important programme to utilise engineering solutions to help and improve care of our patients with eye problems.
      By Tin Aung
    7. “At PhotoniCare we set out to solve the massive problem of frequent misdiagnosis of middle ear infections, and the overuse of antibiotics and referrals to surgery in children that result...We thank the FDA for clearing our TOMi Scope under a new product code unique to our technology, and look forward to bringing this innovation to doctors and patients very soon.”
      By Ryan L. Shelton
    8. The move to the new office space on Fox Drive has been exciting, to say the least...Part of the move includes a build out of a portion of the office space. So the #EnginEarGuys got to try our hand at interior design! Much of the design, however, was spearheaded by one of PhotoniCare’s engineers, Heather Howard. She helped the team navigate the moving process and make decisions on everything from our new manufacturing layout to the aesthetics – carpet, paint, and furniture!
      By Ryan L. Shelton
    9. “Our group has spent quite a few years working on developing the underlying imaging technology...This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to better understand how surgical maneuvers impact postoperative visual function.
      By Yuankai K. Tao
    10. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt