1. Recent Articles From Around The Web

    1. DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      OCTA imaging is an emerging modality for the discovery of retinal biomarkers in systemic disease. Several studies have already shown the potential of deep learning algorithms in the medical domain. However, they generally require large amount of manually graded images which may not always be available. In our study, we aim to investigate whether transfer learning can help in identifying patient status from a relatively small dataset. Additionally, we explore if data augmentation may help in improving our classification accuracy. Finally, for the first time, we propose a validation of our model on OCTA images acquired with a different device ...

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    2. Full-field optical coherence tomography—An educational setup for an undergraduate lab

      Full-field optical coherence tomography—An educational setup for an undergraduate lab

      Optical coherence tomography, or in short OCT, is a measurement technique established in the early 1990s for the non-invasive imaging of interfaces in the bulk of biological tissues or other samples. A full-field OCT setup is built from a microscope combined with a Michelson interferometer, where the mirror in one arm is replaced by the sample. Using white light, which is temporally partially coherent, interference fringes disclose the presence of an interface whenever the lengths of both interferometer arms are nearly equal. Scanning one arm allows for a volumetric reconstruction of all interfaces inside the sample. While the importance of ...

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    3. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      We report on the investigation of spectral leakage’s impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches the theoretical resolution limit.

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    4. Axial Super-Resolution Study for Optical Coherence Tomography Images via Deep Learning

      Axial Super-Resolution Study for Optical Coherence Tomography Images via Deep Learning

      Optical coherence tomography (OCT) is a noninvasive, high resolution, and real-time imaging technology that has been used in ophthalmology and other medical fields. Limited by the point spread function of OCT system, it is difficult to optimize its spatial resolution only based on hardware. Digital image processing methods, especially deep learning, provide great potential in super-resolving images. In this paper, the matched axial low resolution (LR) and high resolution OCT image pairs from actual OCT imaging are collected to generate the dataset by our home-made spectral domain OCT (SD-OCT) system. Several methods are selected to super-resolve LR OCT images. It ...

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    5. Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

      Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

      Abstract Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated the structural neuro-retinal abnormalities, especially the thickness in the ganglion cell complex (GCC), in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC thickness in MELAS patients was significantly thinner than that in normal controls even when they had no history of transient homonymous hemianopia. There was a negative correlation between GCC thickness and disease duration. In conclusion, OCT may be an effective tool to monitor and predict disease progression in MELAS patients.

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    6. Evaluation of Accuracy and Agreement of Optical Coherence Tomography Angiography Interpretation of Common Retinal Findings and Diagnoses

      Evaluation of Accuracy and Agreement of Optical Coherence Tomography Angiography Interpretation of Common Retinal Findings and Diagnoses

      Abstract Purpose: To evaluate the accuracy and agreement of OCTA interpretation in cases of common retinal findings and diagnoses, and evaluate the effect of the OCT B-scans on OCTA interpretations. Methods: A case-series study, consisting of a questionnaire with 8 cases demonstrating common retinal conditions of normal, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Each case included OCTA images, and 58 participants were asked to identify retinal findings and provide a diagnosis. Following OCTA interpretation, the corresponding OCT B-scans were revealed and participants were asked again to identify retinal findings and provide a diagnosis. Rates of accuracy and agreement ...

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    7. Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients

      Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients

      AIM To observe the findings of spectral domain optical coherence tomography (SD-OCT) scan in cytomegalovirus retinitis (CMVR). METHODS Forty-six eyes of 33 patients with acquired immunodeficiency syndrome and CMVR were enrolled in the study. Complete ophthalmologic examinations, color fundus photography, SD-OCT and fundus autofluorescence (FAF) were performed for all patients at the first visit and each follow-up visit. Retinal necrosis in CMVR was analyzed on SD-OCT and classified into two types, the typical type and the atypical type. RESULTS Forty-one eyes of active CMVR and 4 eyes of recurrent CMVR were classified into typical type, and 4 eyes with graying ...

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    8. Evaluating anterior segment structure using anterior segment optical coherence tomography in malignant glaucoma after Ahmed valve implantation

      Evaluating anterior segment structure using anterior segment optical coherence tomography in malignant glaucoma after Ahmed valve implantation

      Rationale: Malignant glaucoma is a rare condition that can be associated with surgery for glaucoma. In the present case report, we describe a case of malignant glaucoma occurring a week after Ahmed valve implantation. The change in anterior segment structure was identified using anterior segment optical coherence tomography (AS-OCT). Patient concerns: The 86-year-old woman with pseudoexfoliation glaucoma underwent Ahmed valve implantation. A week later, the intraocular pressure (IOP) increased to 74 mm Hg. Diagnosis: The anterior chamber was totally collapsed with conjunctival injection and edematous cornea. Finally, the patient was diagnosed with malignant glaucoma. The structure of anterior chamber was ...

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    9. Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Purpose To evaluate the agreement between a new UBM and a SS-OCT. Methods The scans of the right eye of each volunteer were obtained using the 2 devices. Data were fitted and recorded including: central corneal thickness (CCT), aqueous depth (AQD) (the distance from endothelium to lens), angle-to-angle distance (ATA), lens thickness (LT), diameter of the lens in the horizontal direction (LDia angle : distance between the sharp angles on both sides of the lens, LDia arc : distance between the vertex of the circular arcs on both sides of the lens), anterior and posterior corneal radius (Rf and Rb). Results 25 ...

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    10. PhD position in the Applied Optics Group, University of Kent, Canterbury UK

      PhD position in the Applied Optics Group, University of Kent, Canterbury UK

      Project Summary Plant cuticle and underlying epidermis forms the outermost layer protecting plants from desiccation and from abiotic and biotic stresses. The cuticle comprises mainly of polyester cutin and epicuticular waxes that help to prevent moisture loss and maintenance of cell turgor. In fruits changes in surface properties play an important role in increasing consumer appeal during maturation through development of ‘blooms’ and colour changes. Importantly, the cuticle and epidermis form a mechanical barrier acting as the first-line in defence against the ingress from plant pathogens. The PhD Studentship will aim to develop optical coherence tomography (a non-invasive high-resolution microscopy ...

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    11. How can optical coherence tomography be used to optimize percutaneous coronary intervention?

      How can optical coherence tomography be used to optimize percutaneous coronary intervention?

      Optical coherence tomography (OCT) imaging provides high resolution assessment of coronary parietal and endoluminal abnormalities. Clinical evidence and intuitive utilization make this tool relevant for use in daily practice in the catheterization laboratory. In the present review, we summarize the benefits of OCT for the optimization of percutaneous coronary intervention (PCI) in daily practice. First, we focus on the characterization of lesion type with a view to anticipating challenges during PCI. Then, we describe the utility of OCT to identify culprit lesions and ambiguous angiographic findings. Finally, we outline targets for optimization after PCI and the mechanisms underlying stent failure.

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    12. When to use intravascular ultrasound or optical coherence tomography during percutaneous coronary intervention?

      When to use intravascular ultrasound or optical coherence tomography during percutaneous coronary intervention?

      Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are intravascular imaging technologies widely used in the cardiac catheterization laboratory. The impact of these modalities for optimizing the acute and longer-term clinical impact following percutaneous coronary intervention (PCI) is supported by a wealth of clinical evidence. Intravascular imaging provides unique information for enhanced lesion preparation, optimal stent sizing, recognizing post PCI complications, and the etiology of stent failure. This review compares and contrasts the key aspects of these imaging modalities during PCI.

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      Mentions: Cleveland Clinic
    13. Optical coherence tomography: fundamentals and clinical utility

      Optical coherence tomography: fundamentals and clinical utility

      Although coronary angiography is the standard method employed to assess the severity of coronary artery disease and to guide treatment strategies, it provides only 2D image of the intravascular lesions. In contrast, intravascular imaging modalities such as optical coherence tomography (OCT) produce cross-sectional images of the coronary arteries at a far greater spatial resolution, capable of accurately determining vessel size as well as plaque morphology, eliminating many of the disadvantages inherent to angiography. This review will discuss the role of OCT in the catherization laboratory for the assessment and management of coronary disease.

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    14. The assessment of intermediate coronary lesions using intracoronary imaging

      The assessment of intermediate coronary lesions using intracoronary imaging

      Intermediate coronary artery stenosis, defined as visual angiographic stenosis severity of between 30–70%, is present in up to one quarter of patients undergoing coronary angiography. Patients with this particular lesion subset represent a distinct clinical challenge, with operators often uncertain on the need for revascularization. Although international guidelines appropriately recommend physiological pressure-based assessment of these lesions utilizing either fractional flow reserve (FFR) or quantitative flow ratio (QFR), there are specific clinical scenarios and lesion subsets where the use of such indices may not be reliable. Intravascular imaging, mainly utilizing intravascular ultrasound (IVUS) and optical coherence tomography (OCT) represents an ...

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    15. In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations

      In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations

      In vivo imaging of plaque instability has been considered to have a great potential to predict future coronary events and evaluate the stabilization effect of novel anti-atherosclerotic medical therapies. Currently, there are several intravascular imaging modalities which enable to visualize plaque components associated with its vulnerability. These include virtual histology intravascular ultrasound (VH-IVUS), integrated backscatter IVUS (IB-IVUS), optical coherence tomography (OCT), near-infrared spectroscopy and coronary angioscopy. Recent studies have shown that these tools are applicable for risk stratification of cardiovascular events as well as drug efficacy assessment. However, several limitation exists in each modality. The current review paper will outline ...

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    PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston Quantification of plant morphology and leaf thickness with optical coherence tomography Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award Optical coherence tomography in the 2020s—outside the eye clinic 8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020” Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT Open Source Optical Coherence Tomography Software Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio
  6. Recent Quotes

    1. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    2. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    3. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    4. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    5. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    6. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    7. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    8. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    9. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu
    10. This milestone marks the first step towards establishing physician and patient reimbursement for our home OCT pipeline technology...We applaud the AMA’s CPT Editorial panel for establishing codes for billing remote diagnostic services and patient home monitoring services. We believe that a home-based OCT will be the future of monitoring patients with wet AMD, one that allows doctors to individualize their patients’ treatment.
      By Kester Nahen