1. Recent Articles From Around The Web

    1. Multimodal Imaging: Redefining Retinal Disease With Current Technology

      Multimodal Imaging: Redefining Retinal Disease With Current Technology

      Ophthalmic imaging has long been a mainstay of the diagnosis and treatment of eye disease. This aspect of retinal specialists’ practice has undergone many recent advances, leading to an expanding structural understanding of disease processes. The combination of multiple imaging modalities has helped retinal physicians to further understand disease progression and treatment response. In the era of multimodal imaging, recent observations have helped to clarify the underlying pathogenesis of many retinal diseases. Each imaging “modality” has tissue-specific characteristics that have allowed for the redefinition of many common retinal conditions and have led to an evolution of our understanding of vitreoretinal ...

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    2. Coronary plaque rupture with subsequent thrombosis typifies the culprit lesion of non-ST-segment-elevation myocardial infarction, not unstable angina: non-ST-segment-elevation acute coronary syndrome study

      Coronary plaque rupture with subsequent thrombosis typifies the culprit lesion of non-ST-segment-elevation myocardial infarction, not unstable angina: non-ST-segment-elevation acute coronary syndrome study

      Recently, unstable angina pectoris (UAP) and non-ST-segment-elevation myocardial infarction (NSTEMI) have been considered together because they exhibit indistinguishable clinical and electrocardiogram features, and constitute non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). However, no optical coherence tomography (OCT) studies have reported the association between vulnerable plaque morphology and clinical characteristics in NSTE-ACS patients based on assessment of clinical symptoms and myocardial necrosis. The aim of this study was to investigate the differences in clinical characteristics and plaque morphology assessed by OCT between patients with UAP and NSTEMI. Preinterventional OCT images of 84 NSTE-ACS patients were studied, 19 with NSTEMI and 65 with UAP ...

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    3. Continuous intraoperative OCT guided management of post-deep anterior lamellar keratoplasty descemet’s membrane detachment

      Continuous intraoperative OCT guided management of post-deep anterior lamellar keratoplasty descemet’s membrane detachment

      Continuous intraoperative optical coherence tomography (iOCT) integrated into the operating microscope is a new modification in the current operating microscope to aid in the surgical procedures involving both the anterior and the posterior segment. This helps in intraoperative planning, modification of the surgical steps if required and confirmation of the surgical endpoint in the operating room itself. iOCT was used for the successful management of descemet’s membrane detachment (DMD) following deep anterior lamellar keratoplasty (DALK) with intracameral injection of 20% Sulphur hexafluoride. The gas was injected under direct visualization through the microscope with continuous real time monitoring of the ...

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    4. Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

      Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

      Purpose To measure corneal epithelial thickness (CET) in healthy adults and to investigate its variation with age by use of anterior segment optical coherence tomography (OCT). Methods A total of 210 healthy individuals were enrolled and divided into four, almost equally sized groups on the basis of age: 18–29 years (group 1), 30–44 years (group 2), 45–59 years (group 3), and 60–80 years (group 4). The CET and total corneal thickness in the central area (diameter 6.0 mm) of each patient were obtained by Fourier-domain OCT, and the regional thickness and topographic variability were compared ...

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    5. Artifactual Flow Signals Within Drusen Detected by OCT Angiography

      Artifactual Flow Signals Within Drusen Detected by OCT Angiography

      BACKGROUND AND OBJECTIVE: To demonstrate possible flow artifacts when imaging drusen with optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Patients with drusen were enrolled in a prospective OCT study using the Zeiss AngioPlex OCTA instrument (Carl Zeiss Meditec, Dublin, CA). Two kinds of en face slabs were created for visualizing both structure and flow. The first slab followed the contour of Bruch's membrane. The second slab had an inner boundary following the retinal pigment epithelium (RPE) contour and an outer boundary following the contour of Bruch's membrane. The structure and flow signals from within the drusen were ...

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    6. A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      Neovascularization may be associated with cat-scratch neuroretinitis in the absence of retinal vascular occlusion. Bartonella organisms establish an intimate relationship with the vascular endothelium, causing angioproliferative lesions, which might represent a dedicated pathogenic strategy for expanding the bacterial host cell habitat. In the eye, pathological angiogenesis caused by Bartonella has been described as peripapillary or macular choroidal neovascularization, but the presence of neovascularization within foci of chorioretinitis has never before been reported. The authors present a case of Bartonella chorioretinitis in which optical coherence tomography angiography, by detecting erythrocyte motion, was able to identify neovessels inside the infectious focus.

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    7. Spectral-Domain Optical Coherence Tomography Findings in Lipemia Retinalis

      Spectral-Domain Optical Coherence Tomography Findings in Lipemia Retinalis

      Severe hypertriglyceridemia can give rise to a fundus appearance with whitish-colored retinal vessels called lipemia retinalis. A 52-year-old man with hypertriglyceridemia presented with a best-corrected visual acuity of 20/20 in both eyes and creamy-white retinal vessels on fundus. Spectral-domain optical coherence tomography (SD-OCT) revealed hyperreflective and engorged retinal vessels and white dots mainly accumulated in the inner nuclear and ganglion cell layer. Follow-up fundus examination after plasmapheresis sessions revealed normal retinal vessels. The hyperreflective appearance of the retinal vessels in OCT reversed rapidly 5 days after the treatment, whereas hyperreflective dots in retina disappeared slowly in 3 months. OCT ...

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    8. Optical Coherence Tomography Angiography Demonstration of Choroidal Neovascularization in Malattia Leventinese

      Optical Coherence Tomography Angiography Demonstration of Choroidal Neovascularization in Malattia Leventinese

      In a case of Malattia Leventinese, optical coherence tomography angiography led to the diagnosis of type 1 neovascularization, despite absence of evidence on conventional dye-based angiography. The authors hypothesize that, at least in some cases, accumulation of subretinal fluid in Malattia Leventinese could be due to a subretinal pigment epithelium (RPE) neovascular component rather than creation of hydrophobic barrier at the RPE and Bruch's membrane.

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    9. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their shortened lifetime. Despite continuous efforts, the mechanisms leading to CHDs remain largely unclear. In part, this is because most developmental cardiology studies fail to address the influential role of ...

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    10. OPTIC COHERENCE TOMOGRAPHY SHOWS INFLAMMATION AND DEGENERATION IN MAJOR DEPRESSIVE DISORDER PATIENTS CORRELATED WITH DISEASE SEVERITY

      OPTIC COHERENCE TOMOGRAPHY SHOWS INFLAMMATION AND DEGENERATION IN MAJOR DEPRESSIVE DISORDER PATIENTS CORRELATED WITH DISEASE SEVERITY

      Background Previous research has consistently detected inflammation in the etiology of depression and neuroimaging studies have demonstrated grey matter abnormalities implying a neurodegenerative process in depression. The aim of this study was to compare ganglion cell layer (GCL), and inner plexiform layer (IPL) volumes and retinal nerve fiber layer (RNFL) thickness between first episode and recurrent major depressive disorder (MDD) patients and controls using optic coherence tomography (OCT) in order to detect findings supporting a degenerative process. Also choroid thicknesses of the same groups were compared to examine effects of inflammation on MDD. Methods This study included 50 recurrent MDD ...

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    11. Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration

      Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration

      BACKGROUND AND OBJECTIVE: To evaluate the spectral-domain optical coherence tomography (SD-OCT) characteristics of the junctional zone corresponding to areas of increased autofluorescence (IAF) at the margin of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). PATIENTS AND METHODS: SD-OCT and fundus autofluorescence (FAF) images from untreated eyes with GA available from archived studies at Doheny Image Reading Center were evaluated. Areas of definite decreased autofluorescence (DDAF) corresponding to GA, and areas of IAF at the margins of the GA were manually segmented. Eyes with evidence of IAF were selected. Following manual registration of FAF and OCT data, areas ...

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    12. Optical Coherence Tomography Parameters in Morbidly Obese Patients Who Underwent Laparoscopic Sleeve Gastrectomy

      Optical Coherence Tomography Parameters in Morbidly Obese Patients Who Underwent Laparoscopic Sleeve Gastrectomy

      Purpose . To investigate changes in optical coherence tomography parameters in morbidly obese patients who had undergone laparoscopic sleeve gastrectomy (LSG). Methods . A total of 41 eyes of 41 morbidly obese patients (BMI ≥ 40) who had undergone LSG were included in study. The topographic optic disc parameters, central macular thickness (CMT), total macular volume (TMV), and retinal ganglion cell layer (RGCL) were measured by spectral-domain optical coherence tomography (SD-OCT). Subfoveal choroidal thickness (SFCT) was measured by enhanced deep imaging-optical coherence tomography (EDI-OCT). Results . The mean CMT was   μ m,   μ m, and   μ m preoperatively, 3 months postoperatively, and 6 months postoperatively, respectively ( ). The ...

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    13. Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

      Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

      Background Optical coherence tomography (OCT) is a non-invasive optical imaging method that has proven useful in various fields such as ophthalmology, dermatology and neuroscience. In ophthalmology, significant progress has been made in retinal layer segmentation and enhancement of OCT images. There are also segmentation algorithms to separate epidermal and dermal layers in OCT-acquired images of human skin. New Method We describe simple image processing methods that allow automatic segmentation and enhancement of OCT images of rodent brain. Results We demonstrate the effectiveness of the proposed methods for OCT-based microangiography (OMAG) and tissue injury mapping (TIM) of mouse cerebral cortex. The ...

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    14. Angiographically minimal but functionally significant coronary lesion confirmed by optical coherence tomography

      Angiographically minimal but functionally significant coronary lesion confirmed by optical coherence tomography

      A 48-year-old man visited our hospital due to exertional chest pain. His resting electrocardiogram exhibited a T wave inversion in the inferior leads. A transthoracic echocardiogram showed a preserved left ventricular systolic function without any regional wall motion abnormalities. Multi-detector computed tomography was performed to evaluate the existence of any coronary artery disease and it revealed a significant stenosis in the right coronary artery; however, there was a minimal atherosclerotic lesion in the left coronary artery (Fig. 1A). The right coronary angiogram showed a significant stenosis in the mid portion of the right coronary artery and percutaneous coronary intervention for ...

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    15. Early Optical Coherence Tomography Findings after Vitreomacular Traction Release

      Early Optical Coherence Tomography Findings after Vitreomacular Traction Release

      After the introduction of intravitreal ocriplasmin (Jetrea; ThromboGenics, Iselin, NJ) for symptomatic vitreomacular traction (VMT), reports began surfacing of diffuse ellipsoid zone (EZ) changes and acute visual loss after treatment. 1–5 Two explanations for these abnormalities have been proposed. 2 Because ocriplasmin is a recombinant protease, the drug may cleave layers in the outer retina beyond the vitreomacular interface. Alternatively, because these changes are found primarily after successful VMT release, the effect could be secondary to a transient increase in mechanical traction on the retina when the vitreous separates.

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    In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching Characterization of Automotive Paint by Optical Coherence Tomography High efficiency for prostate biopsy qualification with full-field OCT after training Research Associate Position in OCT at the University of Maryland Analyzing the Evolution of Membrane Fouling via a Novel Method Based on 3D Optical Coherence Tomography Imaging Postdoctoral Fellow Position at the Advanced Ophthalmic Imaging Laboratory at Indian Universitiy Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography Coin-Sized Scanner to Target Blindness Optical module to extend any Fourier-domain optical coherence tomography system into a polarisation-sensitive system Postdoctoral research position for Biomedical/Optics Engineer Scientist at Harvard Medical School and Wellman Center Post-Doc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography
  7. Recent Quotes

    1. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      By Wolfgang Drexler
    2. This gives us a very controlled way of looking at ovarian cancer.
      By Jennifer K. Barton
    3. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      By Jennifer K. Barton
    4. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    5. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
      By Philip J. Rosenfeld
    6. Our goal with MicroAngio is to provide a flexible tool that can be used in an optimal fashion for a wide range of applications...MicroAngio comes with customized probes and fixtures for small animal retinal, dorsal window chamber and brain imaging. We also provide a suite of algorithms for data analysis essential for angiographic imaging.”
      By Nishant Mohan
    7. In the majority of cases it is clinically and dermoscopically possible to differentiate between AK and BCC, but there are difficult situations, especially in early cases or during topical therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear...This data published shows that VivoSight OCT is not only able to differentiate between the two diseases by means of epidermal thickness and signal intensity measurements but also able to be used as a non-invasive technique to determine and monitor the treatment. This technology significantly improves the diagnostic methods currently used resulting in better outcomes for patients.
      By Julia Welzel
    8. We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness...Since we first introduced this technology to markets outside the U.S. fourteen months ago, the technology is in daily clinical use at over 525 clinical sites where it provides a more patient-friendly approach to diseases of the retina that lead to progressive blindness.
      By Jay Wei
    9. In the field of OCT imaging and biometry, size, price and operating power are three critical elements to commercialization in mass market applications...Our MRO system is the first version of OCT with the size, cost and operating power profile to address high volume applications in areas such as mobile personal health monitoring and biometric security.
      By Don Bogue
    10. The clinical benefit to the patient and the work flow to clinics have been a major impact to society.
      By Jay Wei