1. Feature Of The Week: Stanford University Investigates an Approach to Scalable Multiplexing for Parallel Imaging with Interleaved OCT

    We demonstrate highly parallel imaging with interleaved optical coherence tomography (iOCT) using an in-house-fabricated, air-spaced virtually-imaged phased array (VIPA). The air-spaced VIPA performs spectral encoding of the interferograms from multiple lateral points within a single sweep of the source and allows us to tune and balance several imaging parameters: number of multiplexed points, ranging depth, and sensitivity. In addition to a thorough discussion of the parameters and operating principles of the VIPA, we experimentally demonstrate the effect of different VIPA designs on the multiplexing potential of iOCT. Using a 200-kHz light source, we achieve an effective A-scan rate of 3.2-MHz by multiplexing 16 lateral points onto a single wavelength sweep. The improved sensitivity of this system is demonstrated for 3D imaging of biological samples such as a human finger and a fruit fly.

    For more information see recent Article. Courtesy Hee Yoon Lee and Audrey Ellerbee from Stanford University. To share this article click Here.

    Also see request by Stanford on On Sharing Data and Code in the OCT Community by clicking Here.
  2. Recent Articles From Around The Web

    1. Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy

      Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy

      Purpose: While identifying functional and structural parameters of the retina in central serous chorioretinopathy (CSCR) patients, this study investigated how an optical coherence tomography (OCT)-based diagnosis can be significantly supplemented with functional diagnostic tools and to what degree the determination of disease severity and therapy outcome can benefit from diagnostics complementary to OCT. Methods: CSCR patients were evaluated prospectively with microperimetry (MP) and spectral domain optical coherence tomography (SD-OCT) to determine retinal sensitivity function and retinal thickness as outcome measures along with measures of visual acuity (VA). Patients received clinical care that involved focal laser photocoagulation or pharmacotherapy targeting ...

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    2. Left Main Coronary Artery Lesions and Optical Coherence Tomography

      Left Main Coronary Artery Lesions and Optical Coherence Tomography

      Optimal treatment of left main coronary artery (LMCA) lesions requires a highly tailored approach that incorporates patient comorbidities, clinical presentation, the extent of coronary artery disease (CAD), lesion characteristics and local expertise. 1,2 Coronary artery bypass grafting (CABG) is the treatment for LMCA lesions that has the highest evidence level in guideline recommendations. 2,3 However, the evidence for percutaneous coronary intervention (PCI) has increased in recent years and is now class IIa for ostial and trunk LMCA lesions and IIb for distal LMCA bifurcation treatment in stable patients suited for PCI. 2,3 However, these lesion-specific recommendations cannot ...

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      Mentions: St. Jude Medical
    3. Structure-Function Relationship between Frequency-Doubling Technology Perimetry and Optical Coherence Tomography in Glaucoma

      Structure-Function Relationship between Frequency-Doubling Technology Perimetry and Optical Coherence Tomography in Glaucoma

      Purpose: To assess the relationship between the retinal nerve fibre layer (RNFL) thickness and the frequency-doubling technology perimetry (FDT) outcome. Methods: Sixty-two healthy individuals and 72 glaucoma patients were prospectively selected. All participants underwent a reliable FDT and optical coherence tomography (OCT). Pearson correlations were calculated between the unlogged threshold values of FDT and RNFL thicknesses measured by OCT. Results: Mild to moderate correlations were found between a few points from FDT and RNFL thicknesses in the vertical axis. The nasal superior area of FDT and the RNFL thickness at the 7-o'clock position had the strongest correlation (0.434 ...

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    4. Retinal Ganglion Cell Analysis Using High-Definition Optical Coherence Tomography in Patients with Mild Cognitive Impairment and Alzheimer's Disease

      Retinal Ganglion Cell Analysis Using High-Definition Optical Coherence Tomography in Patients with Mild Cognitive Impairment and Alzheimer's Disease

      Background: Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it is associated with retinal ganglion cell loss; however, few data exist to establish this association. Objective: To determine whether macular ganglion cell -inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL), as quantitatively measured by non-invasive in vivo spectral-domain optical coherence tomography (SD-OCT), are altered in patients with AD and mild cognitive impairment (MCI). Methods: Patients with AD and MCI were recruited from dementia/memory clinics, and cognitively normal controls were selected from the Singapore Epidemiology of Eye Disease program. SD-OCT (CIRRUS, software version 6 ...

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    5. Optical coherence tomography and its use in optical neuritis and multiple sclerosis

      Optical coherence tomography and its use in optical neuritis and multiple sclerosis

      Optical coherence tomography is a relatively new non-invasive imaging technique used for obtaining the images and quantifying the layers of the retina. It also provides information about optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume which correlates with axonal loss. Until now, this method was used mainly in ophthalmology; now it has emerged as relevant in neurology as well. RNFL thickness is of particular interest in optic neuropathies and in multiple sclerosis. In sclerosis multiplex, axonal loss occurs as early as the first stages and the quantification of the RNFL thickness by OCT provides an ...

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    6. Comparison of vascular response between everolimus-eluting stent and bare metal stent implantation in ST-segment elevation myocardial infarction assessed by optical coherence tomography

      Comparison of vascular response between everolimus-eluting stent and bare metal stent implantation in ST-segment elevation myocardial infarction assessed by optical coherence tomography

      Aims The long-term safety of second-generation everolimus-eluting stents (EESs) in ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of this study was to evaluate the late vascular response after stent implantation in STEMI between EES and bare-metal stent (BMS) by using optical coherence tomography (OCT). Methods and results A prospective OCT examination was performed in 102 patients at 10 months after stent implantation for treatment of STEMI. A total of 1253 frames with 12 772 struts in 61 EESs and 776 frames with 8594 struts in 41 BMSs were analysed. There were no significant differences in the percentage of ...

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    7. Intra-coronary thrombus evolution during acute coronary syndrome: regression assessment by serial optical coherence tomography analyses

      Intra-coronary thrombus evolution during acute coronary syndrome: regression assessment by serial optical coherence tomography analyses

      Aims We investigated the feasibility of thrombus quantification by frequency-domain optical coherence tomography (FD-OCT) methods in patients with highly thrombotic acute coronary syndrome (ACS) treated by deferred stenting strategy. Methods and results Patients were suitable for inclusion if they presented (i) an ACS that was successfully revascularized by manual thrombo-aspiration and (ii) a large residual thrombus on coronary angiography and initial FD-OCT analysis. These patients underwent a second procedure including FD-OCT analysis after several days of optimal antithrombotic therapy. Serial area measurements within the athero-thrombotic culprit lesion were performed to evaluate the OCT-thrombus score, volume, and length. Sixteen patients (88 ...

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    8. OCT corneal epithelial topographic asymmetry as a sensitive diagnostic tool for early and advancing keratoconus

      OCT corneal epithelial topographic asymmetry as a sensitive diagnostic tool for early and advancing keratoconus

      Purpose: To investigate epithelial thickness-distribution characteristics in a large group of keratoconic patients and their correlation to normal eyes employing anterior-segment optical coherence tomography (AS-OCT). Materials and methods: The study group (n=160 eyes) consisted of clinically diagnosed keratoconus eyes; the control group (n=160) consisted of nonkeratoconic eyes. Three separate, three-dimensional epithelial thickness maps were obtained employing AS-OCT, enabling investigation of the pupil center, average, mid-peripheral, superior, inferior, maximum, minimum, and topographic epithelial thickness variability. Intraindividual repeatability of measurements was assessed. We introduced correlation of the epithelial data via newly defined indices. The epithelial thickness indices were then correlated ...

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    9. The effect of incorrect scanning distance on boundary detection errors and macular thickness measurements by spectral domain optical coherence tomography: a cross sectional study

      The effect of incorrect scanning distance on boundary detection errors and macular thickness measurements by spectral domain optical coherence tomography: a cross sectional study

      Background To investigate the influence of scan distance on retinal boundary detection errors (RBDEs) and retinal thickness measurements by spectral domain optical coherence tomography (SD-OCT). Methods 10 eyes of healthy subjects, 10 eyes with diabetic macular edema (DME) and 10 eyes with neovascular age-related macular degeneration (AMD) were examined with RTVue SD-OCT. The MM5 protocol was used in two consecutive sessions to scan the macula. For the first session, the device was set 3.5 cm from the eye in order to obtain detectable signal with low fundus image quality (suboptimal setting) while in the second session a distance of ...

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    10. Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling

      Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling

      Hemodynamics plays a critical role in the development of atherosclerosis, specifically in regions of curved vasculature such as bifurcations exhibiting irregular blood flow profiles. Carotid atherosclerotic disease can be intervened by stent implantation, but this may result in greater alterations to local blood flow and consequently further complications. This study demonstrates the use of a variant of Doppler optical coherence tomography (DOCT) known as split spectrum DOCT (ssDOCT) to evaluate hemodynamic patterns both before and after stent implantation in the bifurcation junction in the internal carotid artery (ICA). Computational fluid dynamics (CFD) models were constructed to simulate blood velocity profiles ...

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    11. Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

      Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

      1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details.

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    12. Differentiating untreated and cross-linked porcine corneas of the same measured stiffness with optical coherence elastography

      Differentiating untreated and cross-linked porcine corneas of the same measured stiffness with optical coherence elastography

      Structurally degenerative diseases, such as keratoconus, can significantly alter the stiffness of the cornea, directly affecting the quality of vision. Ultraviolet-induced collagen cross-linking (CXL) effectively increases corneal stiffness and is applied clinically to treat keratoconus. However, measured corneal stiffness is also influenced by intraocular pressure (IOP). Therefore, experimentally measured changes in corneal stiffness may be attributable to the effects of CXL, changes in IOP, or both. We present a noninvasive measurement method using phase-stabilized swept-source optical coherence elastography to distinguish between CXL and IOP effects on measured corneal stiffness. This method compared the displacement amplitude attenuation of a focused air-pulse-induced ...

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    13. Miniaturized endoscopic probe for optical coherence tomography with a tiny magnet driving device

      Miniaturized endoscopic probe for optical coherence tomography with a tiny magnet driving device

      This paper proposes an endoscopic probe for optical coherence tomography (OCT) applying on side-imaging of internal organs. The probe consists of single-mode fiber, a gradient-index (GRIN) lens, and a mirror of cylindrical wedge shape attaching to a magnetized metal piece by epoxy with a short steel wire. For OCT scanning, we use magnetic field generated by a larger magnet externally to drive the rotation of the magnetized metal. Compare with other probes, our probe design has two distinct advantages: 1) The exit beam will be unobstructed during 360 degree circumference scanning because there are no connecting wires in the scanning ...

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    14. Detection and analysis of multi-dimensional pulse wave based on optical coherence tomography

      Detection and analysis of multi-dimensional pulse wave based on optical coherence tomography

      Pulse diagnosis is an important method of traditional Chinese medicine(TCM). Doctors diagnose the patients’ physiological and pathological statuses through the palpation of radial artery for radial artery pulse information. Optical coherence tomography (OCT) is an useful tool for medical optical research. Current conventional diagnostic devices only function as a pressure sensor to detect the pulse wave,which can just partially reflect the doctors feelings and lost large amounts of useful information. In this paper, the microscopic changes of the surface skin above radial artery had been studied in the form of images based on OCT. The deformation of surface ...

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    15. Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation

      Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation

      Cardiovascular disease is associated with a high burden of mortality secondary to acute coronary events. Assessment for vulnerable plaque and an understanding of the etiology of stent failure by intravascular imaging may facilitate a greater understanding of the underlying processes responsible for adverse clinical outcomes and guide future therapy. This review focuses on the role of optical coherence tomography in tissue characterization and highlights future advances within the field providing potential enhancement of image interpretation.

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    16. See all articles
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  2. Organizations in the News

    1. (3 articles) Stanford University
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  4. OCT Companies in the News

    1. (3 articles) St. Jude Medical
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    1. (3 articles) Optovue RTVue-100
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    3. (1 articles) Lightlab C7 XR OCT Imaging System
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  6. Picture Gallery

    Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography The EASY-FIT Study Leading Irish University Bio-Photonics Laboratory And Compact Imaging Extend Agreement For Innovative Research Collaboration Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill Depth-encoded all-fiber swept source polarization sensitive OCT Optical coherence elastography for tissue characterization: a review Monte Carlo modeling of angiographic optical coherence tomography Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves Breathing laser as an inertia-free swept source for high-quality ultrafast optical bioimaging Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography
  7. Recent Quotes

    1. Compact Imaging’s MRO™ architecture has clear and sustainable advantages in size, cost, and power consumption over other OCT technologies...We’re delighted that our team in Galway is contributing so significantly to a dramatically different version of OCT technology that can make advanced optical imaging and biometry accessible both outside the clinic to patients and other health-oriented consumers and to developing countries where provision of affordable, ‘fit for purpose’ diagnostics is a real need.
      By Martin J. Leahy
    2. Our collaboration with NUI Galway and Professor Leahy’s labs has been critical to demonstrating the principles and potential applications of MRO™’s low cost, small form factor design...We believe that CI’s MRO™-based sensor development is unlocking the world of high value personal biometrics...The collaboration has been very successful...This is just one of several ways in which Ireland, its people, and its institutions, have supported the development of Compact Imaging. With the strong Irish position in medical device design, development, and manufacturing, we expect continued expansion of our presence in Ireland.
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    3. It was a great occasion and reinforced our desire to use the very best of technology with this fast track driving.
      By Tosh Vadhia
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