1. Featured Articles

    1. Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      A postdoctoral research fellow position is available in the Center for Ophthalmic Optics & Lasers Lab ( www.coollab.net ), Casey Eye Institute, Oregon Health & Science University. This is an outstanding opportunity for a candidate to use optical coherence tomography to conduct visual optics research in an academic ophthalmology setting. The researcher on this position will work with a team of scientists, engineers and physicians to develop ultrahigh-performance OCT systems for comprehensive optical characterization of the anterior eye and wide-field ocular surface topography, to improve post-refractive surgery intraocular lens power calculation, therapeutic scleral lens design, diagnosis and classification of corneal shape irregularities ...

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      Mentions: National Institutes of Health David Huang Oregon Health & Science University

    2. Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Conavi Medical Announces Health Canada Approval of Novasight Hybrid System for Visualization During Coronary Angioplasty Procedures

      Conavi Medical Inc. is pleased to announce that it has received a Health Canada Medical Device License for the Novasight Hybrid System. This patented technology is the only clinical system that enables simultaneous imaging of coronary arteries with both intravascular ultrasound (IVUS) and optical coherence tomography (OCT), and was invented at Sunnybrook Research Institute. Angioplasty and stenting is performed four million times around the world every year as an important part of the treatment of coronary artery disease, including patients suffering from heart attacks and angina. Recent randomized studies with existing IVUS systems have shown that intravascular imaging has the ...

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      Mentions: Sunnybrook Health Sciences Centre Brian K. Courtney Conavi Medical Inc.

    3. Finger-mounted quantitative micro-elastography

      Explore OSA | OSA Publishing Probes
      Finger-mounted quantitative micro-elastography

      We present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is rigidly affixed to a 3D-printed thimble that is mounted on the finger. Analogous to manual palpation, the probe compresses the tissue through the force exerted by the finger. The resulting ...

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      Mentions: University of Western Australia University of St. Andrews Andrea Curatolo

    4. Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms?

      Explore Duke Health Neurology , Ophthalmology
      Could An Eye Doctor Diagnose Alzheimer’s Before You Have Symptoms?

      A quick eye exam might one day allow eye doctors to check up on both your eyeglasses prescription and your brain health. A study of more than 200 people at the Duke Eye Center published March 11 in the journal Ophthalmology Retina suggests the loss of blood vessels in the retina could signal Alzheimer’s disease. In people with healthy brains, microscopic blood vessels form a dense web at the back of the eye inside the retina, as seen in 133 participants in a control group. In the eyes of 39 people with Alzheimer’s disease, that web was less ...

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      Mentions: National Institutes of Health Duke University

    5. Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Explore Ophthalmology Retina Neurology , Ophthalmology
      Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

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      Mentions: Duke University Carl Zeiss Meditec

    6. Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy

      Explore Nature Publishing Group
      Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy

      Cellular traction forces (CTFs) play an integral role in both physiological processes and disease, and are a topic of interest in mechanobiology. Traction force microscopy (TFM) is a family of methods used to quantify CTFs in a variety of settings. State-of-the-art 3D TFM methods typically rely on confocal fluorescence microscopy, which can impose limitations on acquisition speed, volumetric coverage, and temporal sampling or coverage. In this report, we present the first quantitative implementation of a new TFM technique: traction force optical coherence microscopy (TF-OCM). TF-OCM leverages the capabilities of optical coherence microscopy and computational adaptive optics (CAO) to enable the ...

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      Mentions: Cornell University Steven G. Adie

    7. Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

      Explore OSA | OSA Publishing
      Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

      Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution ...

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      Mentions: University of Western Australia Brendan F. Kennedy

    8. Postdoctoral/Research Fellow Opening at Australian National University

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoctoral/Research Fellow Opening at Australian National University

      Job Title: Postdoctoral/Research Fellow Location: Canberra / ACT Salary package: $71,509 - $111,365 per annum plus 17% superannuation Terms: Full time, Continuing Contingent Funded (1 year with possibility of renewal) Applications close: 02 Apr 2019 11:55:00 PM AUS Eastern Daylight Time Description: The Department of Quantum Science, Research School of Physics and Engineering at the Australian National University has a research collaboration with an industry partner to develop technology for the inspection of inorganic and organic materials. The Postdoctoral / Research Fellow will be a key member of a multi-disciplinary team to develop next-generation automatic three-dimensional volumetric imaging ...

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    9. The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly

      Explore American Journal of Ophthalmology Ophthalmology
      The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly

      Purpose To describe the synergistic benefits and cost-savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab, in the treatment of exudative age-related macular degeneration (AMD) Design Retrospective literature review and personal perspective. Methods Retrospective literature review and personal perspective. Results The introduction of the first clinically useful OCT instrument coincided with early phase clinical trials of a drug that would become known as ranibizumab. OCT provided a non-invasive imaging strategy that unambiguously showed the macular fluid associated with exudative AMD and the ability of anti-VEGF therapy to resolve this fluid ...

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      Mentions: Philip J. Rosenfeld University of Miami

    10. Functional retinal imaging using adaptive optics swept-source OCT at 1.6  MHz

      Explore OSA | OSA Publishing
      Functional retinal imaging using adaptive optics swept-source OCT at 1.6  MHz

      Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus ...

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      Mentions: John S. Werner Robert J. Zawadzki UCSD

    11. Local wavefront mapping in tissue using computational adaptive optics OCT

      Explore OSA | OSA Publishing
      Local wavefront mapping in tissue using computational adaptive optics OCT

      The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction ...

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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Fredrick A. South

    12. Chief Technology Officer Opening at PhotoniCare

      Explore Optical Coherence Tomography News
      Chief Technology Officer Opening at PhotoniCare

      PhotoniCare, Inc. (www.photoni.care) is a medical device manufacturer located in Champaign, IL. We believe better decisions in patient care need to be made at the front lines of medicine, prior to specialty care, so we can improve outcomes and save on downstream healthcare costs. As a result, we’ve developed a low-cost handheld imaging platform that uses light to see through tissue. Our first product on this platform is empowering front- line providers to make better decisions about middle ear infections, the leading cause of hearing loss, antibiotic use, and surgeries in children. PhotoniCare has developed the TOMi ...

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      Mentions: FDA PhotoniCare

    13. PhotoniCare, Inc. Signs Exclusive Distribution Agreement with Adachi Co., LTD to Commercialize the TOMi Scope in Japan

      Explore Optical Coherence Tomography News Other Business News , Partnership
      PhotoniCare, Inc. Signs Exclusive Distribution Agreement with Adachi Co., LTD to Commercialize the TOMi Scope in Japan

      PhotoniCare, Inc., a medical device company headquartered in Champaign, Illinois, has signed an exclusive distribution agreement with Adachi Co., LTD , (Osaka, Japan) to commercialize PhotoniCare’s TOMi ™ Scope device throughout Japan. PhotoniCare’s TOMi Scope uses an advanced light-based technology to see through the eardrum. For the first time, physicians can view a high-resolution depth image on-screen to directly visualize the middle ear contents. Current diagnostic tools can only provide a view of the surface of the eardrum, so physicians are left to guess, or, unfortunately, employ invasive surgical procedures to diagnosis middle ear pathologies. PhotoniCare’s non-invasive solution eliminates ...

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      Mentions: University of Illinois at Urbana-Champaign Ryan L. Shelton PhotoniCare

    14. Deep Learning for Prediction of AMD Progression: A Pilot Study

      Explore IOVS Journal Ophthalmology
      Deep Learning for Prediction of AMD Progression: A Pilot Study

      Purpose : To develop and assess a method for predicting the likelihood of converting from early/intermediate to advanced wet age-related macular degeneration (AMD) using optical coherence tomography (OCT) imaging and methods of deep learning. Methods : Seventy-one eyes of 71 patients with confirmed early/intermediate AMD with contralateral wet AMD were imaged with OCT three times over 2 years (baseline, year 1, year 2). These eyes were divided into two groups: eyes that had not converted to wet AMD ( n = 40) at year 2 and those that had ( n = 31). Two deep convolutional neural networks (CNN) were evaluated using 5-fold cross ...

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      Mentions: Jonathan D. Oakley Voxeleron

    15. Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Explore Journals NDE/NDT
      Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Coral reefs are highly productive photosynthetic systems and coral optics studies suggest that such high efficiency is due to optimized light scattering by coral tissue and skeleton. Here, we characterize the inherent optical properties, i.e. the scattering coefficient, μ s , and the anisotropy of scattering, g , of eight intact coral species using optical coherence tomography (OCT). Specifically, we describe light scattering by coral skeletons, coenoarc tissues, polyp tentacles and areas covered by fluorescent pigments (FP). Our results reveal that light scattering between coral species ranges from μ s = 3 mm −1 ( Stylophora pistillata ) to μ s = 25 mm −1 ( Echinopora lamelosa ) . For ...

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      Mentions: University of Copenhagen Steven L. Jacques Daniel Wangpraseurt

    16. AO-OCT Comes into Focus

      Explore Photonics.com Ophthalmology
      AO-OCT Comes into Focus

      Adaptive optics (AO) technology is often used to correct for wavefront distortions imparted when light travels through complex optical systems, enhancing image resolution and facilitating diffraction-limited optics. It has played a particularly prominent role in ophthalmic imaging, where retinal tissue imaging is limited by inherent aberrations in the eye. Given the widespread adoption of OCT in clinical diagnostics over the last 20 years, these two techniques should be natural partners. But because of technological limitations on both sides, practical applications of AO-OCT have been difficult to implement. Improved imaging AO refers to a family of techniques used for correcting distortions ...

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      Mentions: University of Maryland Daniel X. Hammer Wasatch Photonics

    17. Fried Illuminates the Future of Dentistry

      Explore NIH Record Newsletter Dentistry
      Fried Illuminates the Future of Dentistry

      For anyone who dreads going to the dentist, there may be light at the end of the tunnel. Advances in laser and light-based imaging technologies may soon change the face of modern dentistry. Dr. Daniel Fried Tooth enamel is almost transparent at longer wavelengths, making it possible to shine near-infrared light on a tooth to detect dental decay. “You can see right into the tooth,” said Dr. Daniel Fried, professor, University of California, San Francisco School of Dentistry. “The enamel looks almost like an ice cube.” Light-based imaging is minimally invasive, providing a safer alternative to an X-ray’s ionizing ...

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      Mentions: Daniel S. Fried UCSF

    18. Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR

      Explore SPIE Digital Library Tunable Sources
      Tunable 1060nm VCSEL co-packaged with pump and SOA for OCT and LiDAR

      A 1060 nm optically pumped tunable VCSEL was formed from an InGaAs/AlGaAs/GaAs half-VCSEL bonded to a MEMS movable mirror on a silicon substrate. The VCSEL was co-packaged in a 14-pin butterfly module with an 825 nm pump laser and a 1060 nm semiconductor optical amplifier. The co-packaged device exhibited shot-noise-limited sensitivity with up to 50 mW output power and 75 nm tunability. Ophthalmic OCT, especially whole-eye imaging and ocular biometry, is considered the primary application of this device. However, we have also investigated LiDAR to greater than 10 meter ranges with non-mechanical beam steering through angular diffraction from ...

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      Mentions: Axsun Technologies Bart Johnson

    19. Soliton microcomb based spectral domain optical coherence tomography

      Explore arxiv.org Broadband Sources
      Soliton microcomb based spectral domain optical coherence tomography

      Spectral domain optical coherence tomography (SD-OCT) has become a widely applied minimally invasive technique for bio-medical imaging[1–4], and industrial process control[5]. One of the most commonly used light source for SD-OCT is based on superluminescent diodes (SLD), which provide a low-noise broadband coverage.[6] Recent advances have allowed creating photonic integrated chipscale frequency combs, that provide an attractive alternative illumination scheme for SD-OCT. Yet to date, the use of such soliton micro-combs in OCT has not been demonstrated or considered. Here we explore the use of soliton microcombs in spectral domain OCT. By using photonic chipscale Si3N4 ...

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      Mentions: Carl Zeiss Meditec Polytechnique Montreal Theo Lasser

    20. BiOS Hot Topics: Changing of the Guard

      Explore Home: SPIE.org
      BiOS Hot Topics: Changing of the Guard

      The near-capacity crowd at their ultimate session this week broke into applause as Rox Anderson opened with "This is the largest meeting in the world for biomedical optics, and that's because of you!" He added that the reason BiOS has grown so popular is the diversity of the intellect and specialties that are featured in the symposium, such as those involved in medicine, bioscience, and physics. James Fujimoto introduced the new BiOS co-chairs, Jennifer Barton of the University of Arizona and Wolfgang Drexler of the University of Vienna. Touching on the impressive backgrounds of each, Fujimoto noted, "we know ...

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      Mentions: James G. Fujimoto Wolfgang Drexler Leiden University

    21. Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      Explore OSA | OSA Publishing
      Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography

      We propose a simplification for a robust and easy to implement fast phase unwrapping (FPU) algorithm that is used to solve the phase wrapping problem encountered in various fields of optical imaging and metrology. We show that the number of necessary computations using the algorithm can be reduced compared to its original version. FPU can be easily extended from two to three spatial dimensions. We demonstrate the applicability of the two- and three-dimensional FPU algorithm for Doppler optical coherence tomography (DOCT) in numerical simulations, and in the imaging of a flow phantom and blood flow in the human retina in ...

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      Mentions: Nicolaus Copernicus University Maciej Szkulmowski Iwona Gorczynska

    22. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Explore Nature Publishing Group Neurology , Oncology
      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

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      Mentions: Institute of Applied Physics Grigory V. Gelikonov Elena V. Zagaynova

    23. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Explore OSA | OSA Publishing Gastroenterology
      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...

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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    24. System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      Explore Optical Coherence Tomography News Jobs & Studentships
      System Engineer Opening at Heidelberg Engineering in Lübeck Germany

      We are looking for In order to support our development department in Lübeck, we are looking for a professionally and personally convincing personality. We offer you an exciting and responsible position in a fast-growing company. Our Lübeck site specialises in OCT technology and systems integration. With your high understanding of systems, you will accompany a project from the initial conception, through the definition of the architecture, the construction of prototypes to testing and handover to production. Your responsibilities System development from the basic concept to production Evaluation of new technological possibilities Definition and elaboration of the system architecture ...

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      Mentions: Heidelberg Engineering
    25. See all articles

  2. Recent Articles From Around The Web

    1. Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Explore ACS Publications Home Page
      Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Optical coherence tomography (OCT) can be utilized with significant speckle reduction techniques and highly-scattering contrast agents for noninvasive, contrast-enhanced imaging of living tissues at the cellular scale. The advantages of reduced speckle noise and improved targeted contrast can be harnessed to track objects as small as 2 μm in vivo, which enables applications for cell tracking and quantification in living subjects. Here we demonstrate the use of Large Gold Nanorods (LGNRs) as contrast agents for detecting individual micron-sized polystyrene beads and single myeloma cells in blood circulation using speckle modulating-OCT (SM-OCT). This report marks the first time that OCT has ...

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      Mentions: Stanford University Adam de la Zerda Elliott D. SoRelle

    2. Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Explore Nature Publishing Group Ophthalmology
      Macular OCT-angiography parameters to predict the clinical stage of nonproliferative diabetic retinopathy: an exploratory analysis

      Background To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with nonproliferative DR (up to ETDRS Level 53) were evaluated with OCTA (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Seven-field photographs of the fundus were taken for DR staging according to the ETDRS-grading scheme. The vessel density in the superficial and deep capillary plexus (SCP and DCP, respectively ...

      Read Full Article
      Mentions: Optovue Optovue RTVue-100

    3. Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Explore SAGE Journals Ophthalmology
      Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them ...

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    4. Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease

      Explore ingentaconnect.com Cardiology
      Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease

      Following on from a previous finding that there was a significant association between the increase in inflammatory monocytes after AMI and microcirculation impairment, and another that direct rennin inhibitors mediate the suppression of inflammatory monocytes after AMI to improve myocardial relief rate, the researchers are setting out to: discover the significance of peripheral blood monocytes in microcirculation impairment; clarify the influence of renin/aldosterone (the renin-angiotensin-aldosterone system is the most important system involved in the regulation of systemic blood pressure, renal blood flow, and monocytes recruitment); and establish a treatment. Initially, the team conducted clinical research involving 50 patients with ...

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      Mentions: Yuichi Ozaki

    5. Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Explore ScienceDirect Otolaryngology
      Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis

      Objectives Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. This study describes UVFP microanatomy and identifies possible vocal fold atrophy using OCT. Methods Three UVFP patients (ages 1, 11, and 17 years) underwent bilateral OCT imaging using a ...

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      Mentions: Harvard University Massachusetts Eye and Ear Infirmary

    6. Optical coherence tomography for diagnosis of BCC

      Explore Wiley Online Library Dermatology
      Optical coherence tomography for diagnosis of BCC

      Basal cell carcinoma (BCC) is the most common form of skin cancer in the world. Its incidence in Europe has increased at an alarming rate of 5.5% per year over the past four decades. In the U.K., the incidence of BCC has risen at a rate six times higher than in the rest of Europe. The diagnosis of BCC typically requires a biopsy of the skin and careful analysis under a microscope. Optical coherence tomography (OCT) is an imaging tool that uses light to visualize the layers underneath the skin surface in real‐time without the need to ...

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    7. MUcociliary Clearance IN Stroke

      Explore Home - ClinicalTrials.gov Pulmonology , Clinical Trials
      MUcociliary Clearance IN Stroke

      Survival and functional outcome of stroke is strongly depending on the occurence of pneumonia (stroke-associated pneumonia, SAP). Early diagnose and treatment of SAP is paramount in the treatment of stroke patients. While dysphagia strongly contributes to its pathogenesis, recent years have also shown a strong risk-modulation by CNS injury induced immunosuppression, making stroke patients more susceptible to SAP. Additionally, murine models of stroke showed changes in mucociliary clearance as possible contributors to SAP. It remains unclear, whether structural integrity and mucociliary clearance of the respiratory epithel change in stroke patients, and whether these changes might contribute to the occurence of ...

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      Mentions: University of Lübeck

    8. Optical Coherence Tomography Investigations and Modeling of the Sintering of Ceramic Crowns

      Explore MDPI Open Access Journals Platform Dentistry
      Optical Coherence Tomography Investigations and Modeling of the Sintering of Ceramic Crowns

      Dental prostheses are sintered in ovens that sometimes suffer from a loss of calibration. This can lead to variations of the sintering temperature outside the range recommended by the manufacturer. Stress and even fractures in dental ceramics may occur, and this leads to the necessity to rebuild the dental construct. The aim of this work is to monitor the quality of sintering processes using an established biomedical imaging technique—optical coherence tomography (OCT). Conventional current procedures imply the fabrication of supplemental samples that add to the expenses and are only evaluated visually. To our knowledge, we were the first to ...

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      Mentions: Adrian G. Podoleanu University of Kent Cosmin Sinescu

    9. Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Explore PR Newswire Ophthalmology , Other Business News
      Optovue Launches New AngioWellness™ Scan at Vision Expo East

      Optovue , the global leader in the development of optical coherence tomography (OCT) and OCT angiography (OCTA), will launch its new AngioWellness™ scan at Vision Expo East in New York , March 21-24, 2019 . The AngioWellness scan utilizes Optovue's advanced AngioVue ® OCTA technology to quickly assess and diagnose new pathologies in patients, including diabetic patients and those who may be at risk for glaucoma. Sample AngioWellness Report AngioWellness combines structural information on retinal and ganglion cell thickness with objective metrics on retinal vasculature into one easy-to-read report. The first of its kind patient-monitoring tool was designed to help eye care professionals ...

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      Mentions: Optovue

    10. Photonics21 digs in for next phase of continental R&D

      Explore Home: SPIE.org
      Photonics21 digs in for next phase of continental R&D

      Laser pen for ‘while you wait' cancer test The Photonics21 team says that another successful PPP-related development has been delivered by the Automatic Detection of VAscular Networks for Cancer Evaluation (ADVANCE) project team. They have produced a portable laser scanner that can diagnose a malignant melanoma in less than one minute, promising to become what its developers describe as "the world‘s first while-you-wait test for skin cancer." The imaging system, intended to eliminate discomfort and uncertainty for patients, is able to fit every stage of disease identification within the short time of a single doctor's appointment. Using a ...

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      Mentions: Michelson Diagnostics Jon Holmes

    11. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      Explore Optical Coherence Tomography News Gastroenterology , Funding
      NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures

      NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...

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      Mentions: National Institutes of Health NinePoint Medical Eman Namati

    12. Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Explore The JAMA Network Cardiology
      Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-term Clinical Stability An In Vivo Optical Coherence Tomography Study

      Importance At one end of the coronary artery disease (CAD) spectrum, there are patients with multiple recurrent acute coronary syndromes (rACS), and at the other end there are those with long-standing clinical stability. Predicting the natural history of these patients is challenging because unstable plaques often heal without resulting in ACS. Objective To assess in vivo the coronary atherosclerotic phenotype as well as the prevalence and characteristics of healed coronary plaques by optical coherence tomography (OCT) imaging in patients at the extremes of the CAD spectrum. Design, Setting, and Participants This is an observational, single-center cohort study with prospective clinical ...

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      Mentions: Mount Sinai School of Medicine Massachusetts General Hospital Harvard University

    13. Cross-polarization optical coherence tomography for brain tumor imaging

      Explore Frontiers Neurology
      Cross-polarization optical coherence tomography for brain tumor imaging

      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) – OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An ...

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      Mentions: Institute of Applied Physics Grigory V. Gelikonov Pavel A. Shilyagin

    14. Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Explore Journals | PLOS Cardiology
      Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling

      Background / Objectives Automatic algorithms for stent struts segmentation in optical coherence tomography (OCT) images of coronary arteries have been developed over the years, particularly with application on metallic stents. The aim of this study is three-fold: (1) to develop and to validate a segmentation algorithm for the detection of both lumen contours and polymeric bioresorbable scaffold struts from 8-bit OCT images, (2) to develop a method for automatic OCT pullback quality assessment, and (3) to demonstrate the applicability of the segmentation algorithm for the creation of patient-specific stented coronary artery for local hemodynamics analysis. Methods The proposed OCT segmentation algorithm ...

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    15. Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Explore ScienceDirect Cardiology
      Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Purpose Despite the controversial effect of elevated heart rate on progression of cardiac allograft vasculopathy (CAV), heart-rate-slowing agents are frequently prescribed with the assumption that higher heart rate predicts worse outcomes in cardiovascular disease. Methods This prospective 2-center trial investigated progression of CAV in 116 heart transplant (HTx) patients. Both baseline (1 month after HTx) and follow-up (12 months after HTx) examinations by coronary optical coherence tomography (OCT) were analyzed using highly automated 3D graph-based segmentation software. Mean heart rate was assessed by 24-hour ambulatory ECG monitoring at baseline and at 12-month follow-ups after HTx. Results During the first post-transplant ...

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      Mentions: University of Iowa Milan Sonka
      16. See all articles
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