1. Recent Articles From Around The Web

    1. Diurnal Stability Of Peripapillary Vessel Density And Nerve Fiber Layer Thickness On Optical Coherence Tomography Angiography In Healthy, Ocular Hypertension And Glaucoma Eyes

      Diurnal Stability Of Peripapillary Vessel Density And Nerve Fiber Layer Thickness On Optical Coherence Tomography Angiography In Healthy, Ocular Hypertension And Glaucoma Eyes

      Purpose: By using optical coherence tomography angiography (OCTA), to evaluate diurnal changes of the following parameters: vessel density in the peripapillary area (PP-VD) and in the optic nerve head (ONH-VD); thickness of retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC). Methods: All prospectively enrolled participants were imaged on the same day at 8 am and 7 pm by means of the XR Avanti device with AngioVue and AngioAnalytics software (Optovue Inc., Fremont, CA, USA). Only eyes with correct automatic segmentation and good-quality images (scan quality > 7/10) were included. Results: Forty-six eyes from 28 patients with glaucoma, 53 ...

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    2. The impact of artificial intelligence in the diagnosis and management of glaucoma

      The impact of artificial intelligence in the diagnosis and management of glaucoma

      eep learning (DL) is a subset of artificial intelligence (AI), which uses multilayer neural networks modelled after the mammalian visual cortex capable of synthesizing images in ways that will transform the field of glaucoma. Autonomous DL algorithms are capable of maximizing information embedded in digital fundus photographs and ocular coherence tomographs to outperform ophthalmologists in disease detection. Other unsupervised algorithms such as principal component analysis (axis learning) and archetypal analysis (corner learning) facilitate visual field interpretation and show great promise to detect functional glaucoma progression and differentiate it from non-glaucomatous changes when compared with conventional software packages. Forecasting tools such ...

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    3. VIS-OCT offers sight line

      VIS-OCT offers sight line

      The benefits of optical coherence tomography (OCT) have long been known as an imaging tool in ophthalmology, enabling the examination of the eye at microscopic resolution. But what may not be widely appreciated is that the use of visible light sources can improve upon the results of this well-developed technique in the detection and understanding of various eye-related diseases such as macular degeneration and glaucoma. While most commercial OCT and OCTA (angiography) systems use NIR light for economic and technical reasons, broadband visible light sources have expanded from 400 to 2000 nm or more. This has enabled the imaging of ...

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    4. Avinger Announces Full Commercial Launch of Pantheris SV

      Avinger Announces Full Commercial Launch of Pantheris SV

      Avinger, Inc. (NASDAQ: AVGR ), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of Peripheral Artery Disease (PAD), today announced the full commercial launch of the Pantheris SV (small vessel) image-guided atherectomy system in the U.S. All current and prospective Lumivascular accounts are now eligible to order the Pantheris SV device. Avinger launched Pantheris SV at select Avinger sites in late July in order to demonstrate the product's ease of use and efficiency across a variety of user approaches and vascular conditions in a real-world clinical setting, as well ...

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      Mentions: Avinger
    5. Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital

      Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital

      Employer Description Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. Led by Guillermo ...

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    6. Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss

      Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss

      Aims To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss. Methods Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF ...

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    7. Miniaturizing medical imaging, sensing technology

      Miniaturizing medical imaging, sensing technology

      Scientists in Christine Hendon's and Michal Lipson's research groups at Columbia University, New York, have used a microchip to map the back of the eye for disease diagnosis. The interference technology, like bat sonar but using light instead of sound waves , used in the microchip has been around for a little while. This is the first time that technical obstacles have been overcome to fabricate a miniature device able to capture high quality images. Ophthalmologists' current optical coherence tomography (OCT) devices and surveyors' light detection and ranging (LIDAR) machines are bulky and expensive. There is a push for ...

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    8. On-chip tunable photonic delay line

      On-chip tunable photonic delay line

      An on-chip tunable photonic delay line is a key building block for applications including sensing, imaging, and optical communication. However, achieving long and tunable delay lines within a small footprint remains challenging. Here, we demonstrate an on-chip tunable photonic delay line using ultralow loss high confinement Si 3 N 4 waveguides with integrated microheaters. As an example of potential application, we embed a 0.4 m delay line within an optical coherence tomography (OCT) system. We show that the delay line can extend the OCT imaging range by 0.6 mm while maintaining a high signal to noise ratio. Our ...

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    9. Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance

      Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance

      Expanding the company's lineup of eye-care product offerings, Canon U.S.A. , Inc., a leader in digital imaging solutions, is pleased to announce the new intuitive, user-friendly Xephilio OCT-A1 Optical Coherence Tomography device from Canon Inc. This device features automated acquisition functionality, which makes it easy to use, allowing healthcare professionals to obtain high-quality reproducible scans and images. The Xephilio OCT-A1 Optical Coherence Tomography device has received FDA 510(k) clearance for sale in the United States of America 1. The Xephilio OCT-A1 Optical Coherence Tomography device, together with the required RX Capture software, computer and LCD monitor (collectively ...

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    10. Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry

      Objectives The aim of this study was to compare angiographic and optical coherence tomography findings following subintimal as opposed to intraplaque recanalization of chronic total occlusions (CTOs). Background There is ongoing controversy regarding outcomes of intraplaque versus subintimal CTO recanalization. Methods Consecutive patients undergoing angiography and intravascular optical coherence tomography following CTO recanalization were included in the ISAR-OCT-CTO (Intracoronary Stenting and Angiographic Results - Optical Coherence Tomography for Chronic Total Occlusions) registry. The study endpoints were percent diameter stenosis and late lumen loss as well as rate of uncovered and malapposed struts. Independent correlates of uncovered and malapposed struts were assessed ...

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    11. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data, including current approaches used in modeling light scattering in tissue and in AC estimation. We also report on demonstrated clinical applications of the AC, such as for atherosclerotic tissue characterization ...

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    12. Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Optical sensors are ubiquitous for their precision and non-contact acquisition, and have enjoyed widespread use in applications such as biosensing, environmental monitoring, and security. Despite their sensitivity, many of these sensors rely on costly laboratory instrumentation, and are not adaptable to the ever-growing volume of consumer detectors and optics that are readily available, making their application limited to benchtop analytics. This work leverages plasmonic resonances and optical coherence phenomena to make modifications upon traditional sensing formats that improve their sensitivity when deployed in off-the-shelf optical systems. In particular, we demonstrate that label-free plasmonic sensors can be combined with electrochemical impedance ...

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    13. Recent progress in optical probing and manipulation of tissue: introduction

      Recent progress in optical probing and manipulation of tissue: introduction

      This feature issue of Biomedical Optics Express represents a cross-section of the most recent work in tissue optics, including exciting developments in tissue optical clearing, deep tissue imaging, optical elastography, nanophotonics in tissue, and therapeutic applications of light, amongst others. A collection of 33 papers provides a comprehensive overview of current research in tissue optics, much of it inspired and informed by the pioneering work of Prof. Valery Tuchin. The issue contains three invited manuscripts and several mini-reviews that we hope will benefit researchers in this exciting area.

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    14. Elimination of Artifacts Caused by the Nonidentity of Parallel Signal-Reception Channels in Spectral Domain Optical Coherence Tomography

      Elimination of Artifacts Caused by the Nonidentity of Parallel Signal-Reception Channels in Spectral Domain Optical Coherence Tomography

      We study the causes of artifact appearance in the images obtained by the method of spectral domain optical coherence tomography with parallel reception of the optical-spectrum components, which are manifested in repetition and overlay of the structural elements of the images of the studied medium with a shift in depth. It is shown that nonidentity of the transfer characteristics of the channels of the multichannel photoreceiving elements is one of the sources of such artifacts. A numerical method for eliminating such artifacts is proposed and experimentally verified. This method is based on using the models whose parameters are estimated by ...

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    15. Changes in Amblyopia Using Optical Coherence Tomography

      Changes in Amblyopia Using Optical Coherence Tomography

      There have been multiple trials to investigate the morphological changes in the macula and retinal nerve fiber layer of amblyopic eyes, due to the different published results and the lack of evident association between these changes and the patients' parameters. So, we perform this study to compare the variations in macular parameters (central thickness, average thickness, macular volume) and peripapillary thickness in different cases of amblyopic eyes versus the normal fellow eyes using spectral-domain optical coherence tomography . In addition, to estimate the relationship of optical coherence tomography variations with different defined patients' parameters (age, sex, best corrected visual acuity, spherical ...

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    16. See all articles
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  2. Organizations in the News

    1. (2 articles) Institute of Applied Physics
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    6. (2 articles) University of Western Australia
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  3. People in the News

    1. (2 articles) Guillermo J. Tearney
    2. (2 articles) Grigory V. Gelikonov
    3. (2 articles) Valentin M. Gelikonov
    4. (2 articles) Christine P. Hendon
    5. (2 articles) Pavel A. Shilyagin
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    12. (1 articles) Zhongping Chen
    13. (1 articles) Steven T. Bailey
    14. (1 articles) Matthew Brenner
    15. (1 articles) Yali Jia
  4. OCT Companies in the News

    1. (2 articles) Canon Medical Systems
    2. (1 articles) Optovue
    3. (1 articles) Wasatch Photonics
    4. (1 articles) Opticent Health
    5. (1 articles) Avinger
  5. Picture Gallery

    Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial Integrated optical system with photonic integrated circuit including coherent optical receiver and optical phased array Optoretinography: optical measurements of human cone and rod photoreceptor responses to light OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT Electromagnetic analysis for optical coherence tomography based through silicon vias metrology Postdoc Position at the University of Southern California Specsavers Installs the 350th Topcon Maestro Fully Automated OCT Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University ZEISS Showcases New CIRRUS 6000 OCT System at the European Society of Retina Specialists 2019 Congress
  6. Recent Quotes

    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      By Joseph A. Izatt
    2. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      By Stephen A. Boppart
    3. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      By Guillermo J. Tearney
    4. I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.
      By Eman Namati
    5. Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.
      By Giulio Guagliumi
    6. We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.
      By Eman Namati
    7. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      By Xincheng Yao
    8. With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.
      By Donald C. Hood
    9. Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.
      By Brian K. Courtney
    10. Being named a Fellow is a great honor, and I am in very illustrious company.
      By Audrey K. Bowden