1. Recent Articles From Around The Web

    1. Optical coherence tomography-guided percutaneous coronary intervention: a review of current clinical applications

      Optical coherence tomography-guided percutaneous coronary intervention: a review of current clinical applications

      Optical coherence tomography (OCT) is an emerging high-resolution intravascular imaging modality that can provide physicians with critical information, thereby enabling precise characterization of plaque morphology and luminal geometry and facilitating pre-intervention lesion assessment. As OCT has a higher sensitivity for lipid-rich plaque characterization than intravascular ultrasound, vulnerable plaque detection by OCT has thus been investigated. By evaluating both the calcium thickness and arc, OCT can be the ideal method for determining both the indication and endpoint of rotational atherectomy for calcified lesions prior to stent implantation. OCT has become applicable for the optimization of stent implantation with immediate and semi-automatic ...

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    2. Initial Study for the Determination of the Sequence of Intersecting Lines between Gel Pens and Seals by Optical Coherence Tomography

      Initial Study for the Determination of the Sequence of Intersecting Lines between Gel Pens and Seals by Optical Coherence Tomography

      Determining the sequence of intersecting lines is a significant issue in the forensic document examination that can reveal the fraud or distinguish between different allegations. Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging technique that has been introduced into forensic science field recently. The potential of OCT as a novel method to determine the sequence of intersecting lines was examined for the first time. In this study, a spectral-domain OCT system with a center wavelength of 900 nm was employed to perform nondestructive examination on determining the sequence of 18 heterogeneous intersecting line samples produced using three types of ...

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    3. Intraoperative optical coherence tomography-assisted displacement of prepapillary membrane in eyes with optic disc pit maculopathy

      Intraoperative optical coherence tomography-assisted displacement of prepapillary membrane in eyes with optic disc pit maculopathy

      Purpose: To determine the efficacy of displacing a prepapillary membrane during vitrectomy assisted by intraoperative optical coherence tomography (OCT) to treat eyes with optic disc pit maculopathy. Method: Pars plana vitrectomy was performed with 27-gauge instruments on 4 eyes of 4 consecutive patients for optic disc pit maculopathy with retinoschisis and foveal detachment. After creating a posterior vitreous detachment, the prepapillary membrane was made visible by brilliant blue G staining. The membrane was peeled from the central retinal vessel and inverted and placed over intraretinal clefts or stuffed into the optic disc pit. These procedures were guided by intraoperative OCT ...

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    4. Morphological Characteristics of Eroded Plaques with Noncritical Coronary Stenosis: An Optical Coherence Tomography Study

      Morphological Characteristics of Eroded Plaques with Noncritical Coronary Stenosis: An Optical Coherence Tomography Study

      Aims: Recent studies suggested plaque erosion with noncritical stenosis could be treated distinctly from that with critical stenosis, but their morphological features remained largely unknown. The present study aimed to investigate morphological features of eroded plaques with different lumen stenosis using optical coherence tomography (OCT). Methods: A total of 348 ST-segment elevated myocardial infarction patients with culprit OCT-defined plaque erosion (OCT-erosion) were analyzed. Based on the severity of lumen area stenosis, all patients with OCT-erosions were divided into the following three groups: Group A (area stenosis <50%, n=50); Group B (50% ≤area stenosis <75%, n=146); Group C (area ...

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    5. Choriocapillaris flow impairment in type 3 macular neovascularization: a quantitative analysis using swept-source optical coherence tomography angiography

      Choriocapillaris flow impairment in type 3 macular neovascularization: a quantitative analysis using swept-source optical coherence tomography angiography

      Purpose: To quantitatively analyze choriocapillaris alterations using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with type 3 macular neovascularization (MNV) and to compare these alterations with eyes presenting with intermediate AMD (iAMD). Methods: Macular 3x3 mm SS-OCTA scans were retrospectively analyzed in eyes with type 3 MNV and in eyes with iAMD. The choriocapillaris en face slabs were extracted from the SS-OCTA device after manual segmentation. En face choriocapillaris flow images were compensated with en face choriocapillaris structure images, followed by the Phansalkar local thresholding method using a window radius of 4 and 8 pixels. Percentage of flow ...

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    6. Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19

      Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19

      The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure as measured by OCT. Correlating endobronchial assessment with multiple breath nitrogen washout and impulse oscillometry will allow the characterisation of the relationship between small airway structural findings and these validated investigations. A small volume lung wash, endobronchial brushings and the collection of a limited number of endobronchial cryobiopsy samples will be performed to better understand the endobronchial environment of the small airways through inflammatory studies. Following the completion ...

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    7. Imaging of Cardiac Transplantation: An Overview

      Heart transplantation (HTx) remains the optimal treatment for selected patients with end-stage advanced heart failure. However, survival is limited early by acute rejection and long term by cardiac allograft vasculopathy (CAV). Even though the diagnosis of rejection is based on histology, cardiac imaging provides a pivotal role for early detection and severity assessment of these hazards. The present review focuses on the use and reliability of different invasive and non-invasive imaging modalities to detect and monitor CAV and rejection after HTx. Coronary angiography remains the corner stone in routine CAV surveillance. However, angiograms are invasive and underestimates the CAV severity ...

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    8. Past, present and future role of retinal imaging in neurodegenerative disease

      Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo . Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly improved their clinical management. Since the retina is an extension of the brain and shares a common embryological origin with the central nervous system, there has also been intense interest ...

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    9. Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography

      Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography

      Embodiments provide systems and methods associated with a reflectance-based projection-resolved (rbPR) optical coherence tomography angiography (OCTA) algorithm which uses optical coherence tomography (OCT) reflectance to enhance the flow signal and suppress the projection artifacts in 3-dimensional OCTA. rbPR improves the vascular connectivity and improved the discrimination of the deeper plexus angiograms in healthy eyes, compared to prior PR-OCTA method. Additionally, rbPR removes flow projection artifacts more completely from the outer retinal slab in the eyes with age-related macular degeneration, and preserves vascular integrity of the intermediate and deep capillary plexuses in the eyes with diabetic retinopathy. Additionally, the rbPR method ...

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    10. Health collaborations forged at CIIE begin to bear fruit

      Health collaborations forged at CIIE begin to bear fruit

      Two months after the third China International Import Expo ended in Shanghai, some exhibitors from the healthcare sector have disclosed that collaborations forged during the event have now materialized in the form of new drugs, innovative systems and technologies benefiting patients and the general public. It transpires that several agreements were clinched between pharmaceutical multinationals and local healthcare authorities, institutions, schools and enterprises during the third CIIE. Their partnerships' objective is to exploit inherent advantages and synergies in order to make the healthcare ecosystem in the country more innovative. Executives of US-headquartered Boston Scientific said they had forged a strategic ...

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    11. Method for determining the topography of the cornea of an eye

      Method for determining the topography of the cornea of an eye

      A method for determining the topography of the cornea of an eye on the basis of an optical, contactless data capture. In the method for determining the topography of the cornea of an eye, which is based on a deflectometric method, the deflectometric measurements are carried out with the aid of a keratometric method by virtue of additional OCT-based scans being made at the keratometric measurement points, wherein the two measurement systems are registered to one another and both the keratometric and the OCT-based measurement values are recorded and used for mutual calibration to determine and output the topographic data ...

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    12. Optical measurement system using multicore optical fiber

      Optical measurement system using multicore optical fiber

      An optical-fiber measurement system includes an optical system that generates light and a spatial optical switch that is coupled to the optical system that processes the light generated by the optical system and generates light at a plurality of spatially distributed optical ports. A respective one of a plurality of optical cores at a first end of a multicore optical fiber is positioned to receive light from a respective one of the plurality of spatially distributed optical ports, where the light generated at the plurality of spatially distributed optical ports propagates through the multicore optical fiber. Distal optics is positioned ...

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      Mentions: Eric A. Swanson
    13. Fiber optic rotary joints and methods of using and manufacturing same

      Fiber optic rotary joints and methods of using and manufacturing same

      One or more fiber optic rotary joints (FORJ), free space beam combiners, OCT, SEE and/or fluorescence devices and systems for use therewith, methods of manufacturing same and storage mediums are provided. One or more embodiments of FORJs may be used with numerous applications in the optical field, including, but not limited to, OCT and fluorescence applications. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments.

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    14. High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation

      High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation

      Motion contrast optical coherence tomography angiography (OCTA) entails a precise identification of dynamic flow signals from the static background, but an intermediate region with voxels exhibiting a mixed distribution of dynamic and static scatterers is almost inevitable in practice, which degrades the vascular contrast and connectivity. In this work, the static-dynamic intermediate region was pre-defined according to the asymptotic relation between inverse signal-to-noise ratio (iSNR) and decorrelation, which was theoretically derived for signals with different flow rates based on a multi-variate time series (MVTS) model. Then the ambiguous voxels in the intermediate region were further differentiated using a shape mask ...

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    15. A Novel 3D Segmentation Approach for Extracting Retinal Layers from Optical Coherence Tomography Images

      A Novel 3D Segmentation Approach for Extracting Retinal Layers from Optical Coherence Tomography Images

      Purpose Accurate segmentation of retinal layers of the eye in 3‐D Optical Coherence Tomography (OCT) data provides relevant information for clinical diagnosis. This manuscript describes a 3D segmentation approach that uses an adaptive patient‐specific retinal atlas, as well as an appearance model for 3D OCT data. Methods To reconstruct the atlas of 3D retinal scan, the central area of the macula (macula mid‐area) where the fovea could be clearly identified, was segmented initially. Markov Gibbs Random Field (MGRF) including intensity, spatial information, and shape of 12 retinal layers were used to segment the selected area of retinal ...

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  2. Organizations in the News

    1. (3 articles) Harvard University
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  3. People in the News

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  4. OCT Companies in the News

    1. (1 articles) Boston Scientific
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  5. Picture Gallery

    Investigation of Gd2O3: Er3+/Yb3+ Upconversion Nanoparticles (UCNPs) as a Multi‐model Contrast Agent for Functional Optical Coherence Tomography In Vivo Quantitative Analysis of Anterior Chamber White Blood Cell Mixture Composition Using Spectroscopic Optical Coherence Tomography Integrated System for Combined Optical Coherence Tomography-Raman Spectroscopy of Neocaridina denticulate sinensis Postdoctoral Research Fellowships (Machine Vision/Image Analysis) at Massachusetts General Hospital The Thorlabs OCT team is proud to present a webinar given by Dr. Brendan Kennedy from the University of Western Australia - January 20, 2021 Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposur Photonics for Forensics: new publication on peer-reviewed journal Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings Comprehensive review of surgical microscopes: technology development and medical applications Nanoplus Launches Superluminescent Eiodes (SLD) in the Spectral Band from 760 nm to 2900 nm Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model Ultra-Low Contrast Percutaneous Coronary Intervention Guided by Optical Coherence Tomography Complicated by Coronary Perforation
  6. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu