1. Recent Articles From Around The Web

    1. Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Purpose The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. Methods Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center. These morphologic characteristics were compared with functional variables [best-corrected visual acuity (BCVA), contrast sensitivity (CS), retinal sensitivity/microperimetry, fixation stability], and patients’ subjective handicap from CSC using the National ...

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    2. Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice

      Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice

      We report on a study to assess the feasibility of a swept source-based speckle variance optical coherence tomography setup for monitoring cutaneous microvasculature. Punch wounds created in the ear pinnae of diabetic mice were monitored at different times post wounding to assess the structural and vascular changes. It was observed that the epithelium thickness increases post wounding and continues to be thick even after healing. Also, the wound size assessed by vascular images is larger than the physical wound size. The results show that the developed speckle variance optical coherence tomography system can be used to monitor vascular regeneration during ...

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    3. REPEATABILITY OF CHOROIDAL THICKNESS MEASUREMENTS ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IN HEALTHY AND DIABETIC INDIVIDUALS

      REPEATABILITY OF CHOROIDAL THICKNESS MEASUREMENTS ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IN HEALTHY AND DIABETIC INDIVIDUALS

      Purpose: To assess the intrasession repeatability of choroidal thickness measurements obtained using swept-source optical coherence tomography in Type 2 diabetic (T2D) patients and healthy controls. Methods: This was a single-center, prospective, observational, cross-sectional study with consecutive inclusion of 33 healthy subjects and 43 T2D patients. Subjects underwent three consecutive swept-source optical coherence tomography scans in a single session. After automatic delineation of the choroid, subfoveal choroidal thickness, and thickness at 500-μm intervals up to 2,500 μm nasal and temporal from the fovea were measured using the software caliper by the same operator. Intraclass correlation coefficients (ICCs), coefficients of ...

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    4. Observation of curative effect of intravitreal injection of conbercept in wet age-related macular degeneration: Optical coherence tomography analysis after injection

      Observation of curative effect of intravitreal injection of conbercept in wet age-related macular degeneration: Optical coherence tomography analysis after injection

      To observe the clinical efficacy of intravitreal injection of conbercept in the treatment of wet age-related macular degeneration (wAMD), optical coherence tomography (OCT) and the best corrected visual acuity (BCVA) was observed to measure the changes of anatomical changes of central macular thickness (CMT) and the area and volume of retinal pigment epithelium (RPE) uplift. Fifteen patients (15 eyes) with wet AMD were enrolled in this study. All patients underwent intravitreal injection of conbercept of 0.05 mL once. After 1 week, 1 month, and 3 months, OCT and BCVA were used to examine and to compare with the preoperative ...

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    5. In vivo classification of human skin burns using machine learning and quantitative features captured by optical coherence tomography

      In vivo classification of human skin burns using machine learning and quantitative features captured by optical coherence tomography

      We report the first fully automated detection of human skin burn injuries in vivo , with the goal of automatic surgical margin assessment based on optical coherence tomography (OCT) images. Our proposed automated procedure entails building a machine-learning-based classifier by extracting quantitative features from normal and burn tissue images recorded by OCT. In this study, 56 samples (28 normal, 28 burned) were imaged by OCT and eight features were extracted. A linear model classifier was trained using 34 samples and 22 samples were used to test the model. Sensitivity of 91.6% and specificity of 90% were obtained. Our results demonstrate ...

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    6. In Vivo Automated Quantification of Thermally Damaged Human Tissue Using Polarization Sensitive Optical Coherence Tomography

      In Vivo Automated Quantification of Thermally Damaged Human Tissue Using Polarization Sensitive Optical Coherence Tomography

      Over the decades numerous technologies have been performed for the quantification of skin injuries, but their poor sensitivity, specificity and accuracy limits their applications. Optical coherence tomography (OCT) can be potential tool for the identification but the modern high-speed OCT system acquires huge amount of data, which will be very time-consuming and tedious process for human interpretation. Our proposed method opens the possibility of fully automated quantitative analysis based on morphological features of thermally damaged tissue, which will become biomarker for the removal of non-viable skin. The proposed method is based on multi-level ensemble classifier by dissociating morphological features (A-line ...

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    7. A Comparative Study between Fundus Imaging and Optical Coherence Tomography for the Early Diagnosis of Alzheimer’s Disease

      A Comparative Study between Fundus Imaging and Optical Coherence Tomography for the Early Diagnosis of Alzheimer’s Disease

      Alzheimer’s disease (AD) is a neurodegenerative condition as well as changes in retina region that leads to permanent memory loss. AD is presently creating lot of problems in care taking. There are lot of tests and imaging modalities to be performed for an effective diagnosis of the disease. The most popular of them are Magnetic Resonance Imaging, Positron Emission Tomography and Single Photon Emission CT Scanning. They can provide valuable information regarding the changes in brain regions for diagnosing AD. But the detailed study made on AD suggests that there are some variations on the retina region of the ...

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    8. Visibility of blood flow on optical coherence tomography angiography in a case of branch retinal artery occlusion

      Visibility of blood flow on optical coherence tomography angiography in a case of branch retinal artery occlusion

      Purpose: We report the variability in flow angiogram during the course of branch retinal artery occlusion (BRAO) in a case imaged by optical coherence tomography angiography (OCTA). Case Report: OCTA was performed in a patient with BRAO at initial examination and 6 hours later. Initially, the occluded retinal artery and its branches were not detected on OCTA whereas a slow perfusion was present on fluorescein angiography. Six hours after initial examination, flow was detected on OCTA image in the previously occluded artery. Conclusion: This case confirmed the relevance of using OCTA in monitoring BRAO and showed that capillaries with a ...

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    9. Automatic Quantitative Analysis of Bioresorbable Vascular Scaffold Struts in Optical Coherence Tomography Images Using Region Growing

      Automatic Quantitative Analysis of Bioresorbable Vascular Scaffold Struts in Optical Coherence Tomography Images Using Region Growing

      Bioresorbable vascular scaffolds are new-generation stents that reduce the risk of intimal hyperplasia and late stent thrombosis. Intravascular optical coherence tomography is an important technique to evaluate images about struts. Analyzing strut status, such as apposition and malapposition, is important for the follow-up treatment of patients. Traditionally, it has taken up to 8 hours to manually analyze the strut status. In this study, a new method is presented to detect and quantify struts automatically. Ten pullback runs containing 7720 struts were acquired to validate the algorithm. For apposed/malapposed stent struts, the sensitivity of the method was 93.0% and ...

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    10. Precision of Optic Nerve Head and Retinal Nerve Fiber Layer Parameter Measurements by Spectral-domain Optical Coherence Tomography

      Precision of Optic Nerve Head and Retinal Nerve Fiber Layer Parameter Measurements by Spectral-domain Optical Coherence Tomography

      Purpose: The aim of this study was to assess the repeatability and reproducibility (R&R) of Bruch’s Membrane Opening – based on Minimum Rim Width (BMO-MRW), Minimum Rim Area (BMO-MRA) and peripapillary retinal nerve fiber layer thickness (RNFLT) with the Spectralis OCT (Heidelberg Engineering) for normal and glaucoma subjects. Precise measurement of these parameters can support detection of structural glaucomatous damage and progression. Methods: This cross-sectional study included 16 healthy controls and 16 patients with glaucoma. One eye was randomly selected and included in this study. Subjects underwent 1 baseline and 3 follow-up measurements, using three different Spectralis OCT devices ...

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    11. Evaluation of Femtosecond Laser Versus Manual Clear Corneal Incisions in Cataract Surgery Using Spectral-Domain Optical Coherence Tomography

      Evaluation of Femtosecond Laser Versus Manual Clear Corneal Incisions in Cataract Surgery Using Spectral-Domain Optical Coherence Tomography

      PURPOSE: To investigate the wound healing changes of clear corneal incisions performed with a femtosecond laser or a steel bevel knife in cataract surgery using spectral-domain optical coherence tomography. METHODS: Prospectively, consecutive patients undergoing either femtosecond laser–assisted cataract surgery (femtosecond laser group) using the LenSx laser (Alcon Laboratories, Inc., Fort Worth, TX) or traditional cataract surgery using steel blades (control group) were enrolled. The incidence of posterior wound gape, Descemet's membrane detachment, posterior wound retraction, and the inner and outer corneal incision thicknesses were assessed. RESULTS: Compared to the control group, the femtosecond laser group had significantly lower ...

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    12. Glaucoma Implant Tube Lumen Obstruction Visualized Using Anterior Segment Optical Coherence Tomography

      Glaucoma Implant Tube Lumen Obstruction Visualized Using Anterior Segment Optical Coherence Tomography

      We report a case of glaucoma implant tube lumen obstruction visualized with anterior segment optical coherence tomography (ASOCT) and present its surgical management. The patient was a 66-year-old man with refractory glaucoma associated with traumatic aphakia in the right eye after trabeculectomy, several bleb needling procedures, and scleral fixation of the intraocular lens with pars plana vitrectomy. Finally, we performed Baerveldt implantation at the pars plana of the temporal inferior quadrant with a several Sherwood slit. However, his intraocular pressure (IOP) was >30 mm Hg despite maximum medication for several weeks. We attempted second vitrectomy and completely removed vitreous around ...

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    13. 3D topology of orientation columns in visual cortex revealed by functional optical coherence tomography

      3D topology of orientation columns in visual cortex revealed by functional optical coherence tomography

      Orientation tuning is a canonical neuronal response property of 6-layer visual cortex that is encoded in pinwheel structures with center orientation singularities. Optical imaging of intrinsic signals enables us to map these surface 2D structures, while lack of appropriate techniques has not allowed us to visualize depth structures of orientation coding. Here, we performed functional optical coherence tomography (fOCT), a technique capable of acquiring 3D map of the intrinsic signals, to study the topology of orientation coding inside the cat visual cortex. With this technique, for the first time, we visualized columnar assemblies in orientation coding that had been predicted ...

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    14. Scaffold thrombosis following implantation of the Absorb Bvs in routine clinical practice: Insight into possible mechanisms from optical coherence tomography

      Scaffold thrombosis following implantation of the Absorb Bvs in routine clinical practice: Insight into possible mechanisms from optical coherence tomography

      Objectives To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis. Background The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear. Methods Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging. After guidewire passage or balloon inflations, OCT images were acquired. Pullbacks were assessed offline at each 1 mm longitudinal interval within the treated segment and the 5 mm segments ...

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    15. Indocyanine Green Dye Filling Time for Polypoidal Lesions in Polypoidal Choroidal Vasculopathy Affects the Visibility of the Lesions on OCT Angiography

      Indocyanine Green Dye Filling Time for Polypoidal Lesions in Polypoidal Choroidal Vasculopathy Affects the Visibility of the Lesions on OCT Angiography

      Purpose To elucidate the factors that affect the visibility of polypoidal lesions on OCT angiography (OCTA) based on indocyanine green angiography (ICGA) findings in eyes with polypoidal choroidal vasculopathy (PCV). Design Retrospective, consecutive case series. Participants Thirty-one eyes of 31 patients with PCV diagnosed on ICGA. Methods We compared the numbers of polyps visible on ICGA and on OCTA. The following time points and durations were determined: first appearance of dye in the choroidal arteries, first appearance of dye within a polyp, and the time it took the dye to fill entire lesions. Then we compared visible and invisible polyps ...

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    In vivo high resolution human corneal imaging using full-field optical coherence tomography Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo PhD Scholarship in Multi-Spectral Photo-Acoustic Imaging University of Kent Holographic line field en-face OCT with digital adaptive optics in the retina in vivo Multiple aperture synthetic optical coherence tomography for biological tissue imaging Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography Detection and characterization of early plaque formations by Raman probe spectroscopy and optical coherence tomography: an in vivo study on a rabbit model European Multiple Sclerosis Consortium to use Voxeleron’s Orion for OCT Image Analysis Symposium on Advances in Biomedical Polarimetry, March 12, 2018 in Boston Postdoctoral Researcher - in Imaging Software and Algorithm Development, National University of Ireland, Galway
  6. Recent Quotes

    1. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen
    2. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    3. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    4. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei
    5. Combining en-face OCT with movement detection within blood vessels, we get OCT-A, and with it a new imaging era.
      By Eric H. Souied
    6. Obtaining the Category III CPT code for OCT of the skin is an important step towards our goal of obtaining reimbursement and coverage, and we welcome the new codes that can be used by clinicians to record their clinical use of VivoSight OCT in their practice.
      By Jon Holmes
    7. We showed that you can take effectively any OCT system out there and, with minimal changes, boost its resolution to the point where it can detect anatomical features smaller than the size of a typical cell.
      By Adam de la Zerda
    8. This honor highlights the commitment Avinger has to bring the most advanced technology to market for physicians dedicated to treating PAD and their patients who are affected by this disease...Pantheris radically changes the treatment of vascular disease and the Edison Award represents a win for our entire Lumivascular portfolio.
      By John B. Simpson
    9. While we have been actively advancing our lesion assessment technology for the last two years, we are very pleased to see that the significant Series B investment will give MedLumics the means to complete our best-in-class product, conduct a series of international clinical trials to prove its safety and efficacy, and market it to specialist centers. As the company advances and grows into new areas, we will now expand and develop the team internationally.
      By Eduardo Margallo Balbás
    10. It's the most rapidly adopted ophthalmic technology in history.
      By Joel S. Schuman