1. Feature Of The Week: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

    Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. In this study, the diagnostic value of 3-D OCT in comparison to 2-D OCT in the comprehensive grading of human cartilage degeneration is investigated. In total, 53 human osteochondral samples were harvested. The imaging was performed by obtaining a single B-scan image (2-D OCT) and by collecting 100 consecutive B-scan images to generate a volumetric data set (3-D OCT). OCT images were assessed qualitatively according to a modified version of the DJD classification. OCT images were assessed quantitatively by algorithm-based evaluation of surface irregularity, tissue homogeneity and signal attenuation. In conclusion, the generation of 3-D volumetric datasets as well as multiple reconstructions such as rendering, surface topography, parametric and cross-sectional views proved to be of potential diagnostic value.

    For more information see recent Article. Courtesy of Nicolai Brill and Sven Nebelung from RWTH Aachen University. To share this article click Here.

  2. Featured Articles

    1. Technological platform for vertical multi-wafer integration of miniature imaging instruments

      Explore Conference Proceedings
      Technological platform for vertical multi-wafer integration of miniature imaging instruments

      We describe a technological platform developed for miniaturization of optical imaging instruments, such as laser scanning confocal microscopes or Optical Coherence Tomography devices. The platform employs multi-wafer vertical integration approach, combined with integrated glass-based micro-optics and heterogeneous bonding and interconnecting technologies. In this paper we focus on the unconventional fabrication methods of monolithic micro-optical structures and components in borosilicate glass (e.g. micro beamsplitters, refractive microlenses) for optical beam shaping and routing. In addition, we present hybrid laser-assisted integration of glass ball microlenses on the silicon MEMS actuators for transmissive beam scanning as well as methods of electrical signals distribution ...

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    2. Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Explore Optical Coherence Tomography News Cardiology
      Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics

      Columbia research team creating novel technology to improve diagnosis of peripheral arterial disease A comparison between a cross section of a foot in a healthy and a diabetic patient with peripheral artery disease. The optical tomographic imaging technology shows blood perfusion, or the absence of perfusion, in the issue. Approximately 8 to 12 million people in the United States alone are suffering from peripheral arterial disease (PAD) , a common vascular problem that is also one of the most serious complications of diabetes. Andreas Hielscher, professor of biomedical engineering, electrical engineering and radiology (physics) at Columbia Engineering, is developing a novel ...

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      Mentions: National Institutes of Health Columbia University

    3. Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea

      Explore pnas.org Otolaryngology
      Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea

      Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating down its length as a traveling wave. For over half a century, vibratory measurements to study cochlear traveling waves have been made using invasive approaches such as laser Doppler vibrometry. Although these studies have provided critical information regarding the nonlinear processes within the living cochlea that increase the amplitude of vibration and sharpen frequency tuning, the data have typically been limited to point measurements of basilar membrane vibration. In addition, opening the cochlea may alter its function and affect the findings. Here we describe volumetric ...

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      Mentions: Stanford University Harvard University Audrey K. Ellerbee

    4. Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice

      Explore radcliffecardiology.com Cardiology
      Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice

      Background While many hundreds of studies have been published utilising coronary artery optical coherence tomography (OCT), very few have focused on the application of OCT in daily clinical practice. The following case studies are intended to help guide physicians on specific clinical situations in which OCT can help optimise physician treatment strategies. The cardiac cath lab at Mount Sinai Hospital, New York, New York, is a leader in sharing best practices for improving outcomes in complex coronary cases. Mount Sinai has established guidelines to help drive best practices among interventional cardiologists and fellows in the cath lab. OCT has been ...

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      Mentions: St. Jude Medical

    5. Optical coherence tomography for the diagnosis and evaluation of human otitis media

      Explore KoreaMed Synapse Otolaryngology
      Optical coherence tomography for the diagnosis and evaluation of human otitis media

      We report the application of optical coherence tomography (OCT) to the diagnosis and evaluation of otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard and pneumatic otoscopy, are limited to visualizing the surface of the tympanic membrane (TM), OCT effectively reveals the depth-resolved microstructure below the TM with very high spatial resolution, with the potential advantage of its use for diagnosing different types of OM. We examined the use of 840-nm spectral domain-OCT (SD-OCT) clinically, using normal ears and ears with the adhesive and effusion types of OM. Specific features were identified in two-dimensional OCT images of abnormal ...

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      Mentions: University of Ulsan Jeehyun Kim Kyungpook National University

    6. Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography

      Explore opticsinfobase.org Gynecology
      Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography

      During pregnancy, the uterine cervix is the mechanical barrier that prevents delivery of a fetus. The underlying cervical collagen ultrastructure, which influences the overall mechanical properties of the cervix, plays a role in maintaining a successful pregnancy until term. Yet, not much is known about this collagen ultrastructure in pregnant and nonpregnant human tissue. We used optical coherence tomography to investigate the directionality and dispersion of collagen fiber bundles in the human cervix. An image analysis tool has been developed, combining a stitching method with a fiber orientation measurement, to study axially sliced cervix samples. This tool was used to ...

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      Mentions: Columbia University Christine P. Fleming Hendon

    7. NASA presents Heidelberg Engineering the NASA Certificate of Appreciation

      Explore Optical Coherence Tomography News Ophthalmology
      NASA presents Heidelberg Engineering the NASA Certificate of Appreciation

      Heidelberg Engineering was honored today by visitors from NASA. The guests from NASA: Dr. Christian Otto, Lead Scientist for the Vision Impairment and Intracranial Pressure (VIIP) project ; Dr. Steven Hart, lead flight surgeon for VIIP ; Rachel Brady, VIIP Science Coordinator; and Jennifer Villarreal, Project Manager came for a ceremony to present Heidelberg Engineering with the NASA Certificate of Appreciation in recognition of Heidelberg Engineering’s support in placing a SPECTRALIS ® OCT system on the International Space Station (ISS). During the ceremony, the NASA guests described the physiological challenges encountered with long duration space flight and the research underway to understand ...

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      Mentions: Heidelberg Engineering Heidelberg Spectralis

    8. Parametric imaging of viscoelasticity using optical coherence elastography

      Explore IOPscience
      Parametric imaging of viscoelasticity using optical coherence elastography

      We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin–Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft ...

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      Mentions: David D. Sampson University of Western Australia Robert A. McLaughlin

    9. Automated peroperative assessment of stents apposition from OCT pullbacks

      Explore Computers in Biology and Medicine Cardiology
      Automated peroperative assessment of stents apposition from OCT pullbacks

      This study׳s aim was to control the stents apposition by automatically analyzing endovascular optical coherence tomography (OCT) sequences. Lumen is detected using threshold, morphological and gradient operators to run a Dijkstra algorithm. Wrong detection tagged by the user and caused by bifurcation, struts’presence, thrombotic lesions or dissections can be corrected using a morphing algorithm. Struts are also segmented by computing symmetrical and morphological operators. Euclidian distance between detected struts and wall artery initializes a stent׳s complete distance map and missing data are interpolated with thin-plate spline functions. Rejection of detected outliers, regularization of parameters by generalized cross-validation ...

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    10. Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Explore Optical Coherence Tomography News Cardiology , Other Business News
      Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser has now been developed for use in the treatment of atherosclerotic cardio-vascular disease. DWH Systems, Inc. of Seminole Florida working with ELAN Vascular Technologies has developed a system whereby three OCT imaging heads monitor a femtosecond ablation laser in real-time, to perform micro ablation on the outer surface of diseased arteries. OCT is used first to acquire a 3D, C-scan map of the diseased portion of an artery then develops an ablation map for the system to follow. As ablation is performed, OCT again monitors the lasers cutting process from multiple angles in ...

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      Mentions: Douglas Hamilton DWH Systems

    11. James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      Explore rle.mit.edu
      James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      On February 19 th , the birthday of Nicolaus Copernicus, Professor James G. Fujimoto was awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University in Poland. Professor Fujimoto was awarded the University’s highest academic distinction, Doctor Honoris Causa, by Rector Andrzej Tretyn and Dean Andrzej Kowalczyk in recognition of his contribution to the fields of biomedical optics and medicine, his training and mentoring of young scientists, and his service to the international scientific community. Presentation of the Honorary Doctorate to Prof. Fujimoto by Dean Andrzej Kowalczyk (left) and Rector Andrzej Tretyn (right), photo by Andrzej Romański. The Copernicus University ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Nicolaus Copernicus University

    12. Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      Explore opticsinfobase.org
      Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      We provide a framework for compensating errors within passive optical quadrature demodulation circuits used in swept-source optical coherence tomography (OCT). Quadrature demodulation allows for detection of both the real and imaginary components of an interference fringe, and this information separates signals from positive and negative depth spaces. To achieve a high extinction (∼60 dB) between these positive and negative signals, the demodulation error must be less than 0.1% in amplitude and phase. It is difficult to construct a system that achieves this low error across the wide spectral and RF bandwidths of high-speed swept-source systems. In a prior work ...

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      Mentions: Massachusetts General Hospital Benjamin J. Vakoc

    13. Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      Explore Hindawi Publishing Corporation Dentistry
      Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      This study describes microleakage sensing based on swept-source optical coherence tomography (SS-OCT). With a handheld scanning probe, the SS-OCT system can provide portable real-time imaging for clinical diagnosis. Radiography is the traditional clinical imaging instrument used for dentistry; however, it does not provide good contrast images between filling material and the enamel of treated teeth with microleakage. The results of this study show that microleakage can be detected with oral probing using SS-OCT in vivo . The calculated microleakage length was 401  μ m and the width is 148  μ m, which is consistent with the related histological biopsy measurements. The diagnosis of ...

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    14. Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Explore eurointervention.org Cardiology
      Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Aims: Residual thrombus accumulation around stent struts has been observed after the end of primary PCI and may represent a risk factor for acute stent thrombosis. The aim of this study is to test whether a strategy of prolonged bivalirudin infusion may reduce thrombosis of stent struts as compared to an intraprocedural only administration in subjects undergoing primary PCI. Methods and results: One hundred and sixty patients will be selected from the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) study with all the following inclusion criteria: a) STEMI patients undergoing primary PCI with stent implantation, b ...

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      Mentions: Carlo Di Mario Evelyn Regar Hector M. Garcia-Garcia

    15. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Explore AME Publishing Company Gynecology
      Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Background: Endocervical mucus acts as an important barrier to block human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). Disruption of the mucus layer increases the risk of infection for females. An effective method to image the mucus properties can serve as a pre-screening step to risk-stratify the susceptible population. Methods: We proposed to use optical coherence tomography (OCT) to quantitatively measure the thickness of endocervical mucus. We used a home-built bench-top OCT system to monitor the dynamic change in mucus thickness of a cultivated sample. We also fabricated a prototype endoscopic OCT probe to demonstrate potential in ...

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      Mentions: Northwestern University Ji Yi Hao F. Zhang

    16. Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      Explore opticsinfobase.org
      Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      We demonstrate three-dimensional structural and functional retinal imaging with line-field parallel swept source imaging (LPSI) at acquisition speeds of up to 1 MHz equivalent A-scan rate with sensitivity better than 93.5 dB at a central wavelength of 840 nm. The results demonstrate competitive sensitivity, speed, image contrast and penetration depth when compared to conventional point scanning OCT. LPSI allows high-speed retinal imaging of function and morphology with commercially available components. We further demonstrate a method that mitigates the effect of the lateral Gaussian intensity distribution across the line focus and demonstrate and discuss the feasibility of high-speed optical angiography ...

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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    17. Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      Explore SPIE | Journal Dentistry
      Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      A technology to characterize early enamel lesions is needed in dentistry. Optical coherence tomography (OCT) is a noninvasive method that provides high-resolution cross-sectional images. The aim of this study is to compare OCT with microfocus x-ray computed tomography ( μ CT ) for assessment of natural enamel lesions in vitro . Ten human teeth with visible white spot-like changes on the enamel smooth surface and no cavitation (ICDAS code 2) were subjected to imaging by μCT (SMX-100CT, Shimadzu) and 1300-nm swept-source OCT (Dental SS-OCT, Panasonic Health Care). In μ CT , the lesions appeared as radiolucent dark areas, while in SS-OCT, they appeared as areas of ...

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      Mentions: University of Washington Yasunori Sumi Tokyo Medical & Dental University

    18. Depth-encoded synthetic aperture optical coherence tomography of biological tissues with extended focal depth

      Explore opticsinfobase.org
      Depth-encoded synthetic aperture optical coherence tomography of biological tissues with extended focal depth

      Optical coherence tomography (OCT) has proven to be able to provide three-dimensional (3D) volumetric images of scattering biological tissues for in vivo medical diagnostics. Unlike conventional optical microscopy, its depth-resolving ability (axial resolution) is exclusively determined by the laser source and therefore invariant over the full imaging depth. In contrast, its transverse resolution is determined by the objective’s numerical aperture and the wavelength which is only approximately maintained over twice the Rayleigh range. However, the prevailing laser sources for OCT allow image depths of more than 5 mm which is considerably longer than the Rayleigh range. This limits high ...

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      Mentions: VU University Amsterdam Jianhua Mo Mattijs de Groot

    19. Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Explore Wiley Online Library Cardiology
      Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Representative magnetomotive signal (green) using targeted and non-targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a ...

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      Mentions: National Institutes of Health Stephen A. Boppart University of Illinois at Urbana-Champaign

    20. Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Explore Optical Coherence Tomography News Dermatology , Funding , Other Business News
      Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, is pleased to announce that it has closed the £2.5 million First Tranche of its Series B financing. This was led by strategic investor, global medical technology business Smith & Nephew and included new investor Kent County Council as well as existing investors. The £2.5 million investment will be used to expand the Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-centre clinical biopsy avoidance study and explore further applications of ...

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      Mentions: Michelson Diagnostics FDA Michelson Diagnostics Vivosight

    21. Current and evolving uses of optical coherence tomography in the genitourinary tract

      Explore Home - Springer Urology
      Current and evolving uses of optical coherence tomography in the genitourinary tract

      Optical coherence tomography is an emerging imaging modality that provides high-resolution, real-time, cross-sectional visualization of urologic tissue with promising results. Early studies have demonstrated detailed, accurate histologic information of tissues sampled. Optical coherence tomography (OCT) has also been applied in evaluating malignancy of the bladder, prostate, and kidney. In the bladder, it can assist in the identification, biopsy, and intraoperative resection of lesions suspicious for bladder cancer. Intraoperative use of OCT during radical prostatectomy can improve visualization of the neurovascular bundle and surgical margins. Several small, ex vivo studies have also shown promising results in the ability of OCT to ...

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      Mentions: University of Florida Li-Ming Su Imalux Niris

    22. OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

      Explore ScienceDirect Cardiology
      OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

      After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core intravascular imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer “vulnerability” to rupture—namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and ...

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      Mentions: Cardiovascular Research Foundation Gary S. Mintz Christos V. Bourantas

    23. Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      Explore IEEE Xplore Ophthalmology , Tunable Sources
      Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      In this paper, we present a 1050 nm electricallypumped micro-electro-mechanically-tunable vertical-cavitysurface- emitting-laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost & complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over 6 mm × 6 ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    24. Polarization sensitive optical frequency domain imaging system for endobronchial imaging

      Explore opticsinfobase.org Pulmonology
      Polarization sensitive optical frequency domain imaging system for endobronchial imaging

      A polarization sensitive endoscopic optical frequency domain imaging (PS-OFDI) system with a motorized distal scanning catheter is demonstrated. It employs a passive polarization delay unit to multiplex two orthogonal probing polarization states in depth, and a polarization diverse detection unit to detect interference signal in two orthogonal polarization channels. Per depth location four electro-magnetic field components are measured that can be represented in a complex 2x2 field matrix. A Jones matrix of the sample is derived and the sample birefringence is extracted by eigenvalue decomposition. The condition of balanced detection and the polarization mode dispersion are quantified. A complex field ...

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      Mentions: Johannes F. de Boer VU University Amsterdam
    25. See all articles

  3. Recent Articles From Around The Web

    1. Multi-wafer bonding technology for the integration of a micromachined Mirau interferometer

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      Multi-wafer bonding technology for the integration of a micromachined Mirau interferometer

      The paper presents the multi-wafer bonding technology as well as the integration of electrical connection to the zscanner wafer of the micromachined array-type Mirau interferometer. A Mirau interferometer, which is a key-component of optical coherence tomography (OCT) microsystem, consists of a microlens doublet, a MOEMS Z-scanner, a focusadjustment spacer and a beam splitter plate. For the integration of this MOEMS device heterogeneous bonding of Si, glass and SOI wafers is necessary. Previously, most of the existing methods for multilayer wafer bonding require annealing at high temperature, i.e., 1100°C. To be compatible with MEMS devices, bonding of different material ...

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    2. Rotational MEMS mirror with latching arm for silicon photonics

      Explore Conference Proceedings Probes
      Rotational MEMS mirror with latching arm for silicon photonics

      We present an innovative rotational MEMS mirror that can control the direction of propagation of light beams inside of planar waveguides implemented in silicon photonics. Potential applications include but are not limited to optical telecommunications, medical imaging, scan and spectrometry. The mirror has a half-cylinder shape with a radius of 300 μm that provides low and constant optical losses over the full angular displacement range. A circular comb drive structure is anchored such that it allows free or latched rotation experimentally demonstrated over 8.5° (X-Y planar rotational movement) using 290V electrostatic actuation. The entire MEMS structure was implemented using ...

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    3. Macular thickness assessed with spectral domain OCT in a population-based study of children: normative data, repeatability and reproducibility and comparison with time domain OCT

      Explore Wiley Online Library Ophthalmology
      Macular thickness assessed with spectral domain OCT in a population-based study of children: normative data, repeatability and reproducibility and comparison with time domain OCT

      Purpose To collect data on macular thickness assessed with Cirrus OCT in healthy children in a population-based study, to examine the repeatability and reproducibility, and to compare the values with Stratus OCT. Methods Fifty-eight 6- to 15-year-old children, born at term, were examined. Best-corrected visual acuity and refraction were assessed. One examiner performed three OCT assessments, and the repeatability was calculated. Thereafter, a second examiner repeated the examinations to calculate the reproducibility. One eye was randomized to be included in the normal material. Finally, the second examiner assessed the macular thickness with the Stratus OCT. Results The mean value (±SD ...

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      Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT Zeiss Stratus OCT

    4. Application of swept-source optical coherent tomography to caries diagnosis

      Explore search.informit.com.au Dentistry
      Application of swept-source optical coherent tomography to caries diagnosis

      Swept-source optical coherence tomography(SS-OCT) is a new imaging technology using optical light with the wavelengths around 1300nm. The SS-OCT provides us the 3 dimensional image with much higher resolution than dental X-ray. The extent of caries lesion is very clearly observed in the obtained image. The purposes of this article is to introduce the recent research on the SS-OCT imaging of tooth and to discuss the possibility of clinical application of the SS-OCT for diagnosing occlusal caries, inter-proximal caries, recurrent caries, root caries, cracks, and monitoring the early caries lesion.

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      Mentions: Tokyo Medical & Dental University Junji Tagami

    5. A fully static OCT sensor using a glass integrated optic chip bonded to a CCD linear camera

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      A fully static OCT sensor using a glass integrated optic chip bonded to a CCD linear camera

      A fully static OCT device is proposed. The glass integrated optic technology is used to have a large Fourier interferogram along an edge of the glass chip bonded on CCD linear detector array without protective glass window. After having described the system principles, first measurements will be presented. For that an optical signal coming from a SLED is divided in two equal parts injected respectively in a reference input and a probe input. It will be demonstrated that an optical phase difference measurement close to 600µm in the air can be achieved with an optical contrast of 30dB.

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    6. Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Explore Home - Springer Cardiology
      Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming

      Objectives Fibrous cap thickness is the most critical component of plaque stability. Therefore, in vivo quantification of cap thickness could yield valuable information for estimating the risk of plaque rupture. In the context of preoperative planning and perioperative decision making, intracoronary optical coherence tomography imaging can provide a very detailed characterization of the arterial wall structure. However, visual interpretation of the images is laborious, subject to variability, and therefore not always sufficiently reliable for immediate decision of treatment. Methods A novel semiautomatic segmentation method to quantify coronary fibrous cap thickness in optical coherence tomography is introduced. To cope with the ...

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      Mentions: Evelyn Regar Gijs van Soest Antonios Karanasos

    7. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      Explore Wiley Online Library Dermatology
      High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      Background and Objective Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography-based microangiography in detecting high-resolution, three-dimensional structural, and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. Materials and Methods A real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1,310 ...

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      Mentions: National Institutes of Health University of Washington Ruikang K. Wang

    8. Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Explore jstage.jst.go.jp Cardiology
      Thin Cap Fibroatheroma Defined as Lipid Core Abutting Lumen (LCAL) on Integrated Backscatter Intravascular Ultrasound

      Background:This study evaluated the ability of a newly developed integrated backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, Japan) to detect optical coherence tomography (OCT)-verified thin cap fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI).Methods and Results:One hundred culprit lesions in 100 consecutive patients with ischemic heart disease who consented to repeated IVUS and OCT prior to PCI were studied. Of 100 lesions, 48 had OCT-verified TCFA with a cap thickness <65 µm. Such lesions had larger percentage lipid area and lipid angle >2 quadrants on IB-IVUS. A ...

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      Mentions: Terumo Corporation Takashi Muramatsu

    9. Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Explore LWW Online Neurology , Ophthalmology
      Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisen grade >2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups: non-atrophic papilledema and atrophic papilledema. Automated SD-OCT segmentation was performed on patients with non-atrophic papilledema and age-matched controls for each of the 9 regions of the Early Treatment Diabetic Retinopathy ...

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      Mentions: Duke University Sina Farsiu Stephanie J. Chiu

    10. Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Explore Canadian Journal of Cardiology Cardiology
      Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 months Following Biolimus A9-Eluting Biodegradable Polymer Coated Stent Implantation

      Background Nobori is a biolimus A9-eluting stent (BES) featured with a biodegradable polymer coated on the abluminal side only. We previously reported that favorable vessel healing was achieved at 6-12 months after BES implantation. However, detailed long-term vessel reaction post-BES deployment is unclear. Methods Twenty-two BESs were serially evaluated by optical coherence tomography (OCT) at 6, 12, and 24 months post-stenting. Average neointimal thickness, uncovered struts and neointimal unevenness score (NUS: each cross section as maximum neointimal thickness in one cross section divided by the average neointimal thickness of the same cross-section) were manually measured. In addition, we evaluated the ...

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      Mentions: Ken-ichi Hirata Junya Shite Toshiro Shinke

    11. Association between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography

      Explore iovs.org Ophthalmology
      Association between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography

      Purpose: This study aimed to evaluate an association between hypertension and macular thickness. Methods: Eight hundreds and twenty-seven Korean adults composed of 163 pairs of twins and their family members were included in this population-based cross-sectional study. Macular thickness was measured with optical coherence tomography at nine macular subfields defined by the Early Treatment of Diabetic Retinopathy Study. Cardiometabolic risk factors, including body mass index (BMI), hypertension, diabetes, lipid profiles, and smoking status, were assessed. Linear mixed regression analysis was conducted with consideration of familial correlations and adjustment for covariates. Results: Age-, sex-, and axial length-adjusted analysis showed that systemic ...

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      Mentions: Seoul National University Sungkyunkwan University Samsung

    12. Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

      Explore Dental Materials Dentistry
      Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

      Objective To evaluate the effect of pre-conditioning enamel white spot lesion (WSL) surfaces using bioactive glass (BAG) air-abrasion prior to remineralization therapy. Methods Ninety human enamel samples with artificial WSLs were assigned to three WSL surface pre-conditioning groups ( n = 30): (a) air-abrasion with BAG-polyacrylic acid (PAA-BAG) powder, (b) acid-etching using 37% phosphoric acid gel (positive control) and (c) unconditioned (negative control). Each group was further divided into three subgroups according to the following remineralization therapy ( n = 10): (I) BAG paste (36 wt.% BAG), (II) BAG slurry (100 wt.% BAG) and (III) de-ionized water (negative control). The average surface roughness and ...

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      Mentions: Kings College London

    13. Quantitative Analysis of Microdistortions in Bowman's Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections

      Explore Healio.com Ophthalmology
      Quantitative Analysis of Microdistortions in Bowman's Layer Using Optical Coherence Tomography After SMILE Among Different Myopic Corrections

      PURPOSE: To quantitatively analyze the characteristics of Bowman’s layer microdistortions after femtosecond laser small incision lenticule extraction (SMILE) among different myopic corrections, and their correlations with stromal lenticule thickness. METHODS: In this nonrandomized, prospective, controlled study, 63 eyes of 32 consecutive patients undergoing SMILE were divided into three groups according to the preoperative spherical equivalent (SE): greater than −6.00 D (20 eyes), −3.00 to −6.00 D (26 eyes), and −3.00 D or less (17 eyes). Measurement by slit-lamp microscope, uncorrected distance visual acuity (UDVA), manifest refraction, and Fourier-domain optical coherence tomography (FD-OCT) were conducted preoperatively ...

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      Mentions: Fudan University

    14. Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      Explore Healio.com Ophthalmology
      Swept-source Optical Coherence Tomography of Retinal Cavernous Hemangioma: A New Imaging Modality

      The authors report a new, non-invasive diagnostic method in the diagnosis of retinal cavernous hemangioma (RCH). A 6-year-old girl was referred for a non-clearing retinal hemorrhage of 6 months’ duration. Fourier-domain optical coherence tomography (FD-OCT) showed an intraretinal lesion with cystic-like internal appearance. Optical shadowing was present, preventing establishment of any subretinal component to the lesion. Swept-source OCT (SS-OCT) showed an intraretinal lesion consisting of a group of clearly defined grape-like caverns with overlying preretinal tissue. Wide-field fundus fluorescein angiography (WF-FFA) confirmed the diagnosis of RCH. SS-OCT was superior to FD-OCT in showing the internal anatomy of the RCH and ...

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      Mentions: Topcon Medical Systems University of Manchester Paulo E. Stanga
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    Technological platform for vertical multi-wafer integration of miniature imaging instruments Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea Application and Practical Use of Optical Coherence Tomography to Guide Percutaneous Coronary Intervention in Clinical Practice Optical coherence tomography for the diagnosis and evaluation of human otitis media Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography NASA presents Heidelberg Engineering the NASA Certificate of Appreciation Parametric imaging of viscoelasticity using optical coherence elastography Automated peroperative assessment of stents apposition from OCT pullbacks Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

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