1. Feature Of The Week

    The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.

    For more information see recent Article. Courtesy Jiawen Li from University of Adelaide. To share this article click Here.
  2. Recent Articles From Around The Web

    1. Non-local Weighted Sparse Representation for OCT Reconstruction

      Non-local Weighted Sparse Representation for OCT Reconstruction

      his repository contains the code associated with the following paper: Ashkan Abbasi, Amirhassan Monadjemi, Leyuan Fang, Hossein Rabbani, "Optical coherence tomography retinal image reconstruction via nonlocal weighted sparse representation," J. Biomed. Opt. 23(3), 036011 (2018), doi:10.1117/1.JBO.23.3.036011. We introduce a method for OCT retinal image denoising and interpolation. If you find it useful, kindly cite the above paper. For more detail, see https://github.com/ashkan-abbasi66/NWSR

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    2. Multimodality Imaging to Detect Vulnerable Plaque in Coronary Arteries and Its Clinical Application (Book Chapter)

      Multimodality Imaging to Detect Vulnerable Plaque in Coronary Arteries and Its Clinical Application (Book Chapter)

      Postmortem studies have described the association between the thin-cap fibroatheroma (TCFA) and the occurrence of acute coronary syndrome (ACS). Both noninvasive and invasive techniques have been refined and used as a research tool to visualize the plaque at a high risk of disruption. There has been a considerable effort to develop the imaging modalities that offer detailed visualization of coronary pathology and accurately predict the adverse cardiac outcomes. This chapter provides an overview of the current and experimental coronary imaging methods to detect vulnerable plaque and discuss the potential implication of multimodality imaging in clinical practice.

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    3. Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Purpose . To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods . Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear. The conjunctival overlap was ranked as the percentage of the edge covered by the conjunctiva. The frequency of occurrence for visualized peripheral ...

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    4. Optical coherence tomography angiography in glaucoma care

      Optical coherence tomography angiography in glaucoma care

      Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. Optical coherence tomography angiography (OCTA) is the non-invasive in vivo imaging of the vasculature located within the retina and optic nerve head area. The principle of OCTA is to use the variations in OCT signals caused by moving particles as the contrast mechanism for imaging of flow. Several algorithms which aim to maximize the contrast signal and minimize the noise have been developed including the phase-based techniques, intensity-based techniques (e.g., split-spectrum amplitude decorrelation ...

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      Mentions: Shan C. Lin
    5. Optical Coherence Tomography for Brain Imaging (Book Chapter)

      Optical Coherence Tomography for Brain Imaging (Book Chapter)

      Optical coherence tomography (OCT) is an imaging technique based on the detection of light back-reflected or backscattered by tissue. Based on the principles of low-coherence interferometry, OCT provides rapid volumetric imaging with micrometer-scale resolution. OCT has been massively successful in ophthalmology where it became a routine tool for retinal diagnostics. In recent years, however, OCT has also been applied to other fields including—amongst others—cardiovascular imaging, endoscopy of the gastrointestinal tract, and neuroimaging. In the brain and other neural tissues, OCT provides contrast for tissue microstructures and enables noninvasive in vivo and in vitro imaging with high resolution. Novel ...

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      Mentions: Bernhard Baumann
    6. High Resolution Wide Field-of-View Optical Coherence Tomography For 3D Imaging (Thesis)

      High Resolution Wide Field-of-View Optical Coherence Tomography For 3D Imaging (Thesis)

      Optical coherence tomography (OCT) is a noninvasive, cross-sectional, and three-dimensional (3D) tomographic imaging modality. It offers subsurface deeper penetration depth and larger scan area than confocal microscopy as well as higher resolution than ultrasound imaging, very suitable for 3D in vivo imaging of eyes, skins, blood vessels, and other non-biomedical samples. However, there is a trade-off problem among lateral resolution, lateral field of view (FOV), and axial imaging depth, limiting the performance of OCT systems. In this dissertation, we report our studies to solve these problems and to make the OCT a competitive tool for a variety of 3D imaging ...

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    7. The CLASS Surgical Site Characteristics in a Clinical Grading Scale and Anterior Segment Optical Coherence Tomography: A One-Year Follow-Up

      The CLASS Surgical Site Characteristics in a Clinical Grading Scale and Anterior Segment Optical Coherence Tomography: A One-Year Follow-Up

      Purpose . We combined a clinical grading scale and swept source anterior segment OCT to describe the successful and failed CLASS. Material and Methods . 23 patients in the successful group and 17 patients in the failed group were compared in terms of the IBAGS grades and AS-OCT findings at one, three, and twelve months postoperatively. Results . The majority in the successful group presented shallow blebs (91%, 57%, and 52% at 1M, 3M, and 12M, resp.). 59% of the failed group presented no bleb (H0 E0) from the early postoperative period with the rate increasing to 88% at 3M and 100% at ...

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    8. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT images. We demonstrate our technique by performing an ILM peel in ex vivo eyes using low ICG concentrations and laser powers. These results establish the feasibility of PT-OCT for intraoperative ...

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    9. Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography

      Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography

      Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can noninvasively detect fibrotic area in blebs after glaucoma surgery. Evaluation of scar fibrosis in blebs is important not only for predicting bleb function, but also for planning revision trabeculectomy. Herein, we characterize the intensity, phase retardation, and local birefringence images of blebs using PS-OCT. A total of 85 blebs from 85 patients who had undergone trabeculectomy were examined. Both phase retardation and local birefringence images detected fibrotic changes in blebs after glaucoma surgery. Phase retardation images ...

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    10. Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

      Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

      Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree of sensitivity, discrete areas of degeneration in the cerebellum of the SCA1 mouse models. We used ATXN1[82Q] and ATXN1[30Q]-D776 mice in which the transgene is directed only to Purkinje cells. Molecular layer, granular layer, and white matter regions are analyzed using the intrinsic contrasts provided by polarization-sensitive optical coherence tomography. Cerebellar atrophy in SCA1 mice occurred both in gray matter and white matter. While gray matter atrophy is obvious ...

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    11. Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma

      Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma

      Purpose To describe the vascular changes of circumscribed choroidal hemangioma (CCH) after ruthenium-106 brachytherapy using optical coherence tomography angiography (angio-OCT). Methods Seven eyes of 7 patients diagnosed with symptomatic CCH who underwent ruthenium-106 plaque radiotherapy were included in the study. Patients underwent complete ophthalmic examination, bulbar echography and angio-OCT. The same protocol was applied 1 year after ruthenium-106 brachytherapy. Results At baseline, the mean best-corrected visual acuity (BCVA) in affected eyes was 0.67 ± 0.14 logMAR, and the mean tumor thickness was 4.46 ± 0.91 mm measured by standardized A-scan echography. After ruthenium-106 plaque treatment, the mean BCVA ...

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    12. Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

      Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

      Background: Optic disc drusen (ODD) are seen in up to 2.4% of the general population, but the etiology and pathophysiology of the condition is still unknown. The purpose of this study was to determine the prevalence of ODD in a population-based child cohort and to determine if scleral canal diameter and fetal birth and pubertal parameters are associated with the presence of ODD. Methods: This observational, longitudinal population-based birth cohort study, with a nested case–control, included 1,406 children. Eye examinations were performed when the children were between 11 and 12 years of age. Assessment was performed of ...

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    13. Investigation of retinal nerve fiber layer thickness and ganglion cell layer-inner plexiform layer thickness in patients with optic pathway gliomas

      Investigation of retinal nerve fiber layer thickness and ganglion cell layer-inner plexiform layer thickness in patients with optic pathway gliomas

      Purpose This study aimed to compare the optical coherence tomography (OCT) findings of optic pathway glioma (OPG) patients (sporadic or secondary to neurofibromatosis type 1, NF1) with NF1 without OPG patients and healthy controls. Methods This was a prospective, case-control study in which 27 patients (13 with OPGs and 14 with NF1 without OPGs) and 13 control subjects were included. The retinal nerve fiber layer (RNFL) thickness, macular thickness, and ganglion cell layer-inner plexiform layer (GCL-IPL) thickness findings measured using OCT and the results were compared between the groups. Results The macular thickness was significantly lower in the OPG group ...

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    14. PhD Studentship in Ocular Imaging (temporary for 2 years)

      PhD Studentship in Ocular Imaging (temporary for 2 years)

      PhD Studentship in Ocular Imaging (temporary for 2 years) We are seeking an exceptional, highly motivated, and talented PhD student (DVM or MD) to perform in vivo experiments to explore safety and efficacy of novel therapeutic approaches for ocular diseases. In this position you will interact closely with other scientists and technicians in a laboratory. Specifically, you will: Perform ocular examinations of animal models in drug safety studies Apply in vivo imaging modalities with a focus on optical coherence tomography (OCT) Participate in ongoing research projects Train and supervise laboratory technicians and fellow researchers to expand skills and knowledge within ...

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    Postdoctoral positions open at Boston University School of Medicine, Boston Medical Center Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease Postdoctoral Research Position at The University of Liverpool Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy Evaluating micro-optical coherence tomography (μOCT) as a feasible imaging tool for pancreatic disease diagnosis Quantitative measurement of peri-implant bone defects using optical coherence tomography OCTLIGHT Closes Investment Round on Path to Commercialize OCT Swept Source Conavi Medical Announces FDA 510(k) Clearance of the Novasight Hybrid System with Simultaneous Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT) Capabilities NinePoint Medical, Inc. Enters Into A Strategic Partnership and Worldwide Distribution with Merit Medical Systems, Inc. 2017 Beckman-Argyros Award Winner Dr. James Fujimoto Non-local Weighted Sparse Representation for OCT Reconstruction Multimodality Imaging to Detect Vulnerable Plaque in Coronary Arteries and Its Clinical Application (Book Chapter)
  6. Recent Quotes

    1. This is the world's first intravascular imaging system for clinical use with the capability to acquire both IVUS and OCT images using a single catheter. IVUS and OCT are the two most commonly used intravascular imaging technologies in addition to angiography...The Novasight Hybrid System provides the resolution and contrast of OCT with the larger field of view of IVUS, and displays the images in a precisely co-registered fashion.
      By Brian K. Courtney
    2. We started with middle ear infections because of our personal experience with this disease as both parents and patients. Our novel application of optical coherence tomography revolutionizes the diagnosis, treatment and monitoring of the middle ear infections that affect 80% of children.
      By Ryan L. Shelton
    3. With the assistance of the next generation Pantheris system, we helped restore blood flow within the previously blocked segment of the artery and most importantly achieved a great outcome for the patient.
      By Arne G. Schwindt
    4. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      By Ton G. van Leeuwen
    5. This agreement represents an important commercial milestone for Conavi. China has the second largest volume of cardiovascular interventional procedures in the world and is growing quickly as a result of extensive investments in healthcare infrastructure. We are delighted to have found a partner that shares our vision of bringing the potential benefits of advanced image guidance to a broad range of existing and emerging minimally invasive cardiovascuar procedures to patients in China.
      By Brian K. Courtney
    6. We are thrilled to be celebrating three years since we introduced our AngioVue OCT Angiography imaging technology at the AAO in 2014.
      By Jay Wei
    7. Optovue continues to lead innovation in Optical Coherence Tomography (OCT) imaging with the first non-contact technique of measuring the epithelial layer of the cornea...Our epi-mapping software has been the subject of more than 200 publications, underscoring its importance and value in the care of patients with corneal and ocular surface conditions. With epi-mapping, physicians are able to quantify epithelial thickness in patients in a manner that is suitable for daily clinical practice.
      By Jay Wei
    8. Combining en-face OCT with movement detection within blood vessels, we get OCT-A, and with it a new imaging era.
      By Eric H. Souied
    9. Obtaining the Category III CPT code for OCT of the skin is an important step towards our goal of obtaining reimbursement and coverage, and we welcome the new codes that can be used by clinicians to record their clinical use of VivoSight OCT in their practice.
      By Jon Holmes
    10. We showed that you can take effectively any OCT system out there and, with minimal changes, boost its resolution to the point where it can detect anatomical features smaller than the size of a typical cell.
      By Adam de la Zerda