1. Recent Articles From Around The Web

    1. Usefulness of optical coherence tomography with angiographic coregistration in the guidance of coronary stent implantation

      Usefulness of optical coherence tomography with angiographic coregistration in the guidance of coronary stent implantation

      Optical coherence tomography (OCT)-angiography coregistration during stent implantation may be useful to avoid geographical mismatch and incomplete lesion coverage. Untreated lipid-rich plaque at stent edge is associated with subsequent stent edge restenosis. The present study sought to compare the frequency of untreated lipid-rich plaque at the stent edge between OCT-guided percutaneous coronary intervention (PCI) with and without OCT-angiography coregistration. We investigated 398 patients who underwent OCT-guided stent implantation (n = 198 in the coregistration group, and n = 200 in the no coregistration group). In OCT after PCI, untreated lipid-lich plaque was identified by the maximum lipid arc > 180˚ in the ...

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    2. Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma

      Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma

      Background: Effective and aesthetically appealing management options are needed for basal cell carcinoma (BCC), the most common skin cancer. The Nd:YAG laser shows promise, but most studies use biopsy to demonstrate tumor clearance. Optical coherence tomography (OCT) could allow good tumor margin control while enabling recurrence monitoring. Objective: Determine the efficacy of the Nd:YAG laser to treat BCCs while controlling for tumor margin with OCT. Methods: A 1064-nm Nd:YAG laser was applied to treat 119 BCCs in 102 patients, where tumor margins were approximated using OCT. Lesions were treated every 2 months until no residual tumor remained ...

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    3. Known and new facts on basal cell carcinoma

      Known and new facts on basal cell carcinoma

      Basal cell carcinoma (BCC) is the most common malignant tumor in light-skinned people and amounts to about 75 % of all cases of skin cancer. Increasing incidence rates have been reported for decades all over the world. The main risk factors include UV radiation, male sex, light skin type, advanced age, long-term immunosuppression, a positive individual or family history, and certain genodermatoses. BCC metastasizes only rarely, and its mortality is low, but it is associated with significant morbidity. Genetic mutations especially in the hedgehog pathway play an important role in BCC pathogenesis. Non-invasive procedures such as optical coherence tomography or confocal ...

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    4. In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes

      In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes

      Purposes: To examine corneal nerve and retinal nerve characteristics of participants with type 2 diabetes mellitus (T2DM) compared with obese participants without diabetes to discover potential nerve vulnerabilities. Methods: All participants underwent a complete medical examination including a physical examination and blood sample tests. The ophthalmologic examination included best-corrected visual acuity, intraocular pressure, Schirmer test, tear film breakup time, slit-lamp examination, dilated fundus photography, in vivo corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT). Results: The study cohort consisted of 83 eyes of 83 individuals: a group of 44 participants with T2DM, and a control group of 39 obese ...

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    5. Changes in the Macular Vascular Density After Bariatric Surgery Measured by Optical Coherence Tomography Angiograph

      Changes in the Macular Vascular Density After Bariatric Surgery Measured by Optical Coherence Tomography Angiograph

      Objective : The objective is to study the diagnosis of coronary heart disease by optical coherence tomography based on random walk algorithm, so as to assist doctors in diagnosing coronary heart disease. Method : K -means algorithm combined with mathematical morphology provides seed points for random walk algorithm, and realizes semi-automatic segmentation of different kinds of patches. Secondly, by adding the space distance term based on the distance between the edge and the seed point in the weight function, the random walk algorithm is improved, which can make the weak edge patch area not be segmented too much. Results : the results were ...

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    6. Changes in the Macular Vascular Density After Bariatric Surgery Measured by Optical Coherence Tomography Angiography

      Changes in the Macular Vascular Density After Bariatric Surgery Measured by Optical Coherence Tomography Angiography

      Purpose: To evaluate the effect of the weight loss, 3 months after bariatric surgery, on the macular thickness and macular vascular density by optical coherence tomography angiography (OCTA). Methods: Forty obese patients were included in this prospective study. Body mass index (BMI), macular thickness (whole, fovea, parafovea and perifovea), macular vascular density (VD) in superficial capillary plexus (whole, fovea, parafovea and perifovea), and macular vascular density in deep capillary plexus (whole, fovea, parafovea and perifovea) were measured before and 3 months after bariatric surgery. Results: The BMI was significantly reduced postoperatively to 43.75± 4.4 kg/m 2 compared ...

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    7. Effect of Alirocumab on Coronary Plaque in Patients With Coronary Artery Disease Assessed by Optical Coherence Tomography

      Effect of Alirocumab on Coronary Plaque in Patients With Coronary Artery Disease Assessed by Optical Coherence Tomography

      Background Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been demonstrated with significant greater reduction of LDL cholesterol levels and cardiovascular events, compared with standard statin therapy. However, the evidence on the impact of PCSK9 inhibitors on coronary plaque composition and morphology are limited. Methods In this prospective, open-label, randomized study, eligible patients with intermediate coronary lesions and elevated LDL cholesterol values were randomized to either alirocumab 75 mg Q2W plus statin therapy (alirocumab arm) or statin therapy (standard care arm). Optical coherence tomography (OCT) assessment for target lesions were obtained at the baseline and at 36 weeks of ...

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    8. Optical Coherence Tomographic Patterns of Posterior Segment Sticky Heavy Silicone Oil OCT Patterns of Preretinal Sticky HSO

      Optical Coherence Tomographic Patterns of Posterior Segment Sticky Heavy Silicone Oil OCT Patterns of Preretinal Sticky HSO

      Purpose: To describe unique optical coherence tomography (OCT) observations of adherent pre-retinal heavy silicone oil (HSO) following removal. Methods: Retrospective observational review of files and OCT scans of patients who had pars plana vitrectomy with HSO. We investigated the possible precipitating pre-and intra-operative factors and the association with postoperative epiretinal membrane (ERM) and cystoid macular edema (CME). Results: Forty-one eyes from 39 patients were involved. Two characteristic sticky silicone oil (SO) structures were identified in 33 patients (80%): - variably reflective macro-droplets (bubbles) and hyperreflective micro-droplets (dots). The main contributing variable was the tamponade duration. Other notable associations included postoperative ERM ...

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    9. En‑face optical coherence tomography analysis of gold and silver nanoparticles in endodontic irrigating solutions: An in vitro study

      En‑face optical coherence tomography analysis of gold and silver nanoparticles in endodontic irrigating solutions: An in vitro study

      Optical coherence tomography (OCT) is a non‑invasive, non‑radioactive optical diagnostic method based on low‑coherence interferometry, which achieves images with different orientation. In dentistry, its major advantage is represented by the localization and characterization of the smallest defects in hard dental tissues, dental materials and of the smallest details in dental anatomy (supplementary canals, recesses, isthmuses, or intra‑radicular connections). The aim of the present in vitro study was to evaluate using c‑scan en‑face optical coherence tomography, the optical opacity, and the distribution inside the root canal lumen of several extracted human teeth of silver and ...

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    10. The Optical Coherence Tomography and Raman Spectroscopy for Sensing of the Bone Demineralization Process

      The Optical Coherence Tomography and Raman Spectroscopy for Sensing of the Bone Demineralization Process

      Aim of the presented research was to develop an optical sensing system to investigate the demineralization process of the bones. Optical measurement techniques are widely used and increasingly adapted in biological and biomedical applications due to their non-destructive nature and safety. Optical examination of the bone condition could facilitate clinical trials and improve the safety of patients. The authors used a set of complementary methods: polarization-sensitive optical coherence tomography (PS-OCT) and Raman spectroscopy. To stimulate the process of demineralization and gradual removal of the hydroxyapatite, the test samples of chicken bones were placed into 10% acetic acid. Measurements were carried ...

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    11. Choroidal thickness in patients with different refractive status measured by spectral-domain optical coherence tomography

      Choroidal thickness in patients with different refractive status measured by spectral-domain optical coherence tomography

      Aim: To evaluate the choroidal thickness in patients with different refractive status measured by spectral-domain optical coherence tomography. Material and methods : This cross-sectional observational study consisted of 60 subjects, who visited the out-patient department of Ophthalmology, Chattrapati Shivaji Subharti Hospital, Meerut, India and were randomly selected over a period of 1 year. Subjects were classified into three groups based on refractive error: those with a +1 diopter or greater refractive power were assigned to the hyperopia group; those with a diopter lower than +1 and greater than –1 were assigned to the emmetropia group; and those with a –1 diopter ...

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      Mentions: Optovue
    12. Multi-Compartment Spatially-derived Radiomics from Optical Coherence Tomography Predict Anti-VEGF Treatment Durability in Macular Edema Secondary to Retinal Vascular Disease

      Multi-Compartment Spatially-derived Radiomics from Optical Coherence Tomography Predict Anti-VEGF Treatment Durability in Macular Edema Secondary to Retinal Vascular Disease

      Objective: Diabetic macular edema (DME) and retinal vein occlusion (RVO) are the leading causes of visual impairments across the world. Vascular endothelial growth factor (VEGF) stimulates breakdown of blood-retinal barrier that causes accumulation of fluid within macula. Anti-VEGF therapy is the first-line treatment for both the diseases; however, the degree of response varies for individual patients. The main objective of this work was to identify the (i) texture-based radiomics features within individual fluid and retinal tissue compartments of baseline spectral-domain optical coherence tomography (SD-OCT) images and (ii) the specific spatial compartments that contribute most pertinent features for predicting therapeutic response ...

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    13. Changes in Limbal Optical Coherence Tomography Angiography Outcomes in Patients With Overnight Contact Lens Wear

      Changes in Limbal Optical Coherence Tomography Angiography Outcomes in Patients With Overnight Contact Lens Wear

      Objectives: To evaluate the perilimbal vasculature of patients who wear contact lenses (CLs) overnight with optical coherence tomography angiography (OCTA) and compare the results with healthy population. Methods: Forty-two patients were included in this observational study. The OCTA imaging was performed in the temporal quadrant of the perilimbal region using a swept-source optical coherence tomography system (Triton DRI-OCT; Topcon Corporation, Tokyo, Japan). The assessments were made in two depths: starting from the conjunctival epithelium to 200 μm scleral depth and the scleral depth between 200 and 1,000 μm. The vessel density, vessel length density, vessel diameter index, and fractal ...

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    14. Aqueous Humor Cytokine Levels Through Microarray Analysis and a Sub-Analysis Based on Optical Coherence Tomography in Wet Age-Related Macular Degeneration Patients

      Aqueous Humor Cytokine Levels Through Microarray Analysis and a Sub-Analysis Based on Optical Coherence Tomography in Wet Age-Related Macular Degeneration Patients

      Purpose: To evaluate the magnitude of change in optic disc, peripapillary retinal nerve fiber layer (RNFL) and macular parameters measured by swept-source optical coherence tomography (SS-OCT) in glaucomatous eyes after filtration surgery, and to determine any possible relationship between these measurements and baseline factors. Patients and Methods: This multicenter, prospective, consecutive observational study included patients with open-angle glaucoma who required glaucoma filtering surgery (surgical group, 29 eyes) and those with stable disease (control group, 25 eyes). Patients from the surgical group underwent measurement of optic disc, peripapillary retinal nerve fiber layer (RNFL) and macular parameters before and after surgery. Results ...

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    1. (2 articles) World Health Organization
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  4. Picture Gallery

    White Paper on Superluminscent Diodes  by Anritsu Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging Kalman filtered depth prediction using Optical Coherence Tomography for laser bone cutting Notal Vision announces publication of first prospective longitudinal pilot study of daily self-imaging with patient-operated Home OCT in wet AMD patients Unified k-space theory of optical coherence tomography Robotic-arm-assisted flexible large field-of-view optical coherence tomography Anrtisu Introduces a New Swept Light Source Usefulness of optical coherence tomography with angiographic coregistration in the guidance of coronary stent implantation Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma Known and new facts on basal cell carcinoma
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu