1. Feature Of The Week: Tuning of Vernier Tuned DBR Lasers for Optical Comb Swept Source OCT

    Monolithic Vernier tuned distributed Bragg reflector (VT-DBR) lasers are expected to become one of the most promising sources for optical comb swept source optical coherence tomography (SS-OCT) with reduced sensitivity roll-off due to a long coherence length, potential capability for a very fast A-scan rate, and low cost with monolithic structure. However, mainly four problems inhibited an ideal implementations: 1) frequencies deviate from the targeted values when scanned, 2) large amounts of noise appear associated with abrupt changes in injection currents, 3) optically aliased noise appears due to a long coherence length, and 4) the narrow wavelength coverage of a single chip limits resolution. These problems have been solved by developments of a method of dynamical frequency-tuning, a method of selective data sampling to eliminate current switching noise, an interferometer to reduce aliased noise, and an excess-noise-free connection of two serially scanned lasers to enhance resolution. An optical frequency comb SS-OCT system was achieved using super-structure grating distributed Bragg reflector lasers with good sensitivity, no sensitivity roll-off within the principal depth range, good dynamic range of 55-72 dB (depended on the depth) within the principal depth range, and OCT imaging of excellent image penetration. Further improvements of SS-OCT with VT-DBR laser are suggested by numerical simulation of PSF over extended depth ranges.

    For more information see recent Article. Courtesy of Kohji Ohbayashi from Advanced Imaging Co. Ltd. To share this article click Here.

  2. Featured Articles

    1. Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M

      Explore Optical Coherence Tomography News Gastroenterology , Acquisition
      Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M

      Covidien Announces Definitive Agreement to Acquire Given Imaging Advances Covidien strategy to more comprehensively address key specialties and procedures globally Adds Given Imaging’s broad suite of minimally invasive gastrointestinal diagnostic and monitoring solutions Accelerates development of world-class gastrointestinal portfolio focused on serving patient from diagnosis to treatment Accretive to earnings per share beginning in fiscal 2015 Covidien plc (NYSE: COV) and Given Imaging Ltd . (Nasdaq: GIVN) today announced a definitive agreement under which Covidien will acquire all of the outstanding shares of Given Imaging for $30.00 per share in cash, for a total of approximately $860 million, net ...

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    2. Motion artifact and speckle noise reduction in polarization sensitive optical coherence tomography by retinal tracking

      Explore opticsinfobase.org
      Motion artifact and speckle noise reduction in polarization sensitive optical coherence tomography by retinal tracking

      We present a novel polarization sensitive optical coherence tomography (PS-OCT) system with an integrated retinal tracker. The tracking operates at up to 60 Hz, correcting PS-OCT scanning positions during the acquisition to avoid artifacts caused by eye motion. To demonstrate the practical performance of the system, we imaged several healthy volunteers and patients with AMD both with B-scan repetitions for frame averaging and with 3D raster scans. Under large retinal motions with up to 1 mm amplitude at 0.5 ~a few Hz frequency range, motion artifact suppression in the PS-OCT images as well as standard deviation noise reduction in ...

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      Mentions: Christoph K. Hitzenberger Michael Pircher Medical University of Vienna

    3. Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News , Partnership
      Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research

      Phoenix Research Labs, Inc. today announced a partnership with Voxeleron, LLC to lead in the development of optical coherence tomography (OCT) segmentation software. The parties have entered into a strategic partnership to apply Voxeleron segmentation technology to the Phoenix Image-Guided Optical Coherence Tomography (OCT) data. This will allow users to readily analyze retinal layers, precisely measuring changes to thickness and structure over time. “We’re very excited by the opportunity to work with Phoenix. Clearly they have a strong portfolio of technologies optimized for animal eye research, so the addition of image analysis software can only strengthen their customers’ ability ...

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      Mentions: Jonathan D. Oakley Phoenix Research Laboratories Voxeleron

    5. Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

      Explore SPIE | Journal Cardiology
      Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

      During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number of cellular, molecular, and hemodynamic processes. There is growing recognition that mechanical factors may actively drive vascular cell signaling and regulate atherosclerosis disease progression. In advanced plaques, the mechanical properties of the atheroma influence stress distributions in the fibrous cap and mediate plaque rupture resulting in acute coronary events. This review paper explores current optical technologies that provide information on the mechanical properties of arterial tissue to advance our understanding of the mechanical factors involved in atherosclerosis development leading to plaque ...

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      Mentions: Massachusetts General Hospital Harvard University

    6. Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Explore Optical Coherence Tomography News Ophthalmology , Jobs & Studentships
      Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis. One position will be filled by someone with background in vision science while the other will be for a person with experience in a high-resolution imaging modality such as OCT, adaptive optics or scanning laser ophthalmoscope. Strong skills in programming or image processing would be an asset. The positions will be open until filled. Salary will be based on experience and salary scales of the UC. The University of California is committed to diversity. Minorities, women, veterans and persons ...

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      Mentions: John S. Werner UC Davis

    7. A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects

      Explore IEEE Xplore
      A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects

      In optical coherence elastography, images are formed by mapping a mechanical property of tissue. Such images, known as elastograms, are formed on the microscale, intermediate between that of cells and whole organs. Optical coherence elastography holds great promise for detecting and monitoring the altered mechanical properties that accompany many clinical conditions and pathologies, particularly in cancer, cardiovascular disease and eye disease. In this review, we first consider how the mechanical properties of tissue are linked with tissue function and pathology. We then describe currently prominent optical coherence elastography techniques, with emphasis on the methods of mechanical loading and displacement estimation ...

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      Mentions: David D. Sampson University of Western Australia Brendan F. Kennedy

    8. In vivo pump-probe optical coherence tomography imaging in Xenopus laevis

      Explore Wiley Online Library Developmental Biology
      In vivo pump-probe optical coherence tomography imaging in Xenopus laevis

      Currently, optical coherence tomography (OCT), is not capable of obtaining molecular information often crucial for identification of disease. To enable molecular imaging with OCT, we have further developed a technique that harnesses transient changes in light absorption in the sample to garner molecular information. A Fourier-domain Pump-Probe OCT (PPOCT) system utilizing a 532 nm pump and 830 nm probe has been developed for imaging hemoglobin. Methylene blue, a biological dye with well-know photophysics, was used to characterize the system before investigating the origin of the hemoglobin PPOCT signal. The first in vivo PPOCT images were recorded of the vasculature in ...

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      Mentions: Texas A&M University Brian E. Applegate

    9. Optical coherence tomography 2014

      Explore Healio.com Ophthalmology
      Optical coherence tomography 2014

      Optical coherence tomography (OCT) is now widely recognized as the most important retinal imaging technique, replacing angiographic techniques as first-line imaging tools. This has largely been driven by widespread application of retinal pharmacotherapy. As a clinical decision-making tool in that setting, OCT has unparalleled value in delivering important information in a matter of seconds. OCT has dramatically improved the productivity of retinal specialists — ie, the number of patients who can be evaluated in a given clinical session. This special issue on OCT highlights its value as a quantitative tool in assessing retinal anatomy in both health and disease, its power ...

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      Mentions: Carmen A. Puliafito University of Southern California

    10. Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Explore ScienceDirect Dermatology
      Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Background Photodynamic therapy with methyl aminolaevulinate (MAL-PDT) is a widely used non-invasive treatment modality for non-melanoma skin cancer (NMSC). The outcome of MAL-PDT is usually primarily evaluated clinically. Optical coherence tomography (OCT) is a non-invasive imaging technology based on interferiometry. OCT has been proven to provide high accuracy in identifying NMSC lesions and performing thickness measurements of thin tumours. Objectives To describe the OCT morphology in in-vivo NMSC lesions during MAL-PDT treatment and to investigate the use of OCT in evaluating the response of MAL-PDT treated NMSC lesions Methods A total of 18 biopsy-proven basal cell carcinomas and actinic keratoses ...

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      Mentions: Mette Mogensen University of Copenhagen Gregor B. E. Jemec

    11. Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish

      Explore PLoS ONE Developmental Biology
      Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish

      Light-induced lesions are a powerful tool to study the amazing ability of photoreceptors to regenerate in the adult zebrafish retina. However, the specificity of the lesion towards photoreceptors or regional differences within the retina are still incompletely understood. We therefore characterized the process of degeneration and regeneration in an established paradigm, using intense white light from a fluorescence lamp on swimming fish (diffuse light lesion). We also designed a new light lesion paradigm where light is focused through a microscope onto the retina of an immobilized fish (focused light lesion). Focused light lesion has the advantage of creating a locally ...

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      Mentions: Dresden University of Technology Edmund Koch Peter Cimalla

    12. Comparison of longitudinal geometric measurement in human coronary arteries between frequency-domain optical coherence tomography and intravascular ultrasound

      Explore Home - Springer Cardiology
      Comparison of longitudinal geometric measurement in human coronary arteries between frequency-domain optical coherence tomography and intravascular ultrasound

      Previous studies have demonstrated the higher accuracy of frequency-domain optical coherence tomography (FD-OCT) for quantitative measurements in comparison with intravascular ultrasound (IVUS). However, those analyses were based on the cross-sectional images. The aim of this study was to assess the accuracy of FD-OCT for longitudinal geometric measurements of coronary arteries in comparison with IVUS. Between October 2011 and March 2012, we performed prospective FD-OCT and IVUS examinations in consecutive 77 patients who underwent percutaneous coronary intervention with single stent. Regression analysis and Bland-Altman analysis revealed an excellent correlation between the FD-OCT-measured stent lengths and IVUS-measured stent lengths (r = 0.986 ...

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      Mentions: Wakayama Medical University Takashi Kubo Takashi Tanimoto

    13. Stephen A. Boppart named fellow of American Association for the Advancement of Science

      Explore News Bureau
      Stephen A. Boppart named fellow of American Association for the Advancement of Science

      Four University of Illinois at Urbana-Champaign faculty members have been named Fellows of the American Association for the Advancement of Science. Sharon Hammes-Schiffer Kanti Jain William King Stephen A. Boppart, Susan Hammes-Schiffer, Kanti Jain and William P. King are among 388 honorees recognized for their “scientifically or socially distinguished efforts to advance science or its applications.” New fellows will be recognized in a ceremony Feb. 15 at the 2014 AAAS Annual Meeting in Chicago. “This year’s AAAS fellows demonstrate that Illinois is at the forefront of research and innovation,” said Phyllis M. Wise, the chancellor of the Urbana-Champaign campus ...

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      Mentions: Massachusetts Institute of Technology Stephen A. Boppart Stanford University

    14. Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?

      Explore AJP - Heart and Circulatory Physiology Developmental Biology
      Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?

      Alcohol-induced congenital heart defects (CHDs) are frequently among the most life-threatening and require surgical correction in newborns. The etiology of these defects, collectively known as Fetal Alcohol Syndrome (FAS), has been the focus of much study, particularly involving cellular and molecular mechanisms. Few studies have addressed the influential role of altered cardiac function in early embryogenesis, due to a lack of tools with the capability to assay tiny beating hearts. To overcome this gap in our understanding, we used optical coherence tomography (OCT), a non-destructive imaging modality capable of micrometer-scale resolution imaging, to rapidly and accurately map cardiovascular structure and ...

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      Mentions: Andrew M. Rollins Case Western Reserve University Michael W. Jenkins

    15. Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

      Explore ScienceDirect Cardiology
      Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis

      The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.

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      Mentions: Zhongping Chen UC Irvine Steven C. George

    16. Development of a prediction formula of Parkinson disease severity by optical coherence tomography

      Explore Wiley Online Library Neurology , Ophthalmology
      Development of a prediction formula of Parkinson disease severity by optical coherence tomography

      The aims of this study were to assess the peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease (PD), to determine its correlation with disease severity, and to define a simple biomarker for predicting clinical severity. One hundred two eyes from 52 patients affected by PD were compared with 97 eyes from 50 age-comparable controls. In all patients, peripapillary RNFL thickness was measured by optical coherence tomography (OCT). We used the Unified Parkinson's Disease Rating Scale (UPDRS) total score and measured responses in the on medication state. Eyes from patients with PD had a statistically ...

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    17. Comparison of different metrics for analysis and visualization in spectroscopic optical coherence tomography

      Explore opticsinfobase.org
      Comparison of different metrics for analysis and visualization in spectroscopic optical coherence tomography

      Spectroscopic Optical Coherence Tomography (S-OCT) extracts depth resolved spectra that are inherently available from OCT signals. The back scattered spectra contain useful functional information regarding the sample, since the light is altered by wavelength dependent absorption and scattering caused by chromophores and structures of the sample. Two aspects dominate the performance of S-OCT: (1) the spectral analysis processing method used to obtain the spatially-resolved spectroscopic information and (2) the metrics used to visualize and interpret relevant sample features. In this work, we focus on the second aspect, where we will compare established and novel metrics for S-OCT. These concepts include ...

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      Mentions: Duke University Francisco E. Robles Nils C. Gerhardt

    18. Tuning of successively scanned two monolithic Vernier-tuned lasers and selective data sampling in optical comb swept source optical coherence tomography

      Explore opticsinfobase.org Tunable Sources
      Tuning of successively scanned two monolithic Vernier-tuned lasers and selective data sampling in optical comb swept source optical coherence tomography

      Monolithic Vernier tuned super-structure grating distributed Bragg reflector (SSG-DBR) lasers are expected to become one of the most promising sources for swept source optical coherence tomography (SS-OCT) with a long coherence length, reduced sensitivity roll-off, and potential capability for a very fast A-scan rate. However, previous implementations of the lasers suffer from four main problems: 1) frequencies deviate from the targeted values when scanned, 2) large amounts of noise appear associated with abrupt changes in injection currents, 3) optically aliased noise appears due to a long coherence length, and 4) the narrow wavelength coverage of a single chip limits resolution ...

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      Mentions: Kohji Ohbayashi Kitasato University

    19. Thomas Milner Wins University of Texas Inventor of the Year Award

      Explore Home | The University of Texas at Austin
      Thomas Milner Wins University of Texas Inventor of the Year Award

      Thomas Milner , professor of biomedical engineering , was named Inventor of the Year at the university’s annual Inventor Award Ceremony on Nov. 19. Milner’s inventions have helped physicians better detect and diagnose illnesses such as glaucoma and heart disease, and they have helped treat many dermatological conditions. Thomas Milner received the award for his development of light-based therapeutic and diagnostic procedures that treat or prevent disease in humans. Milner pioneered the development of optical-based instrumentation application in clinical settings. “As the holder of 35 patents and the author of five book chapters and 153 scholarly articles, Dr. Milner is ...

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      Mentions: National Institutes of Health Thomas E. Milner CardioSpectra

    20. Evaluating a novel fissure caries model using swept source optical coherence tomography

      Explore jstage.jst.go.jp Dentistry
      Evaluating a novel fissure caries model using swept source optical coherence tomography

      The objective of this study was to determine the efficacy of Swept Source Optical Coherence Tomography (SS-OCT) imaging in assessing a novel fissure caries model. Samples were imaged by both near infrared based SS-OCT and high resolution x-ray tomography imaging to non-destructively quantify artificial lesions. The mean relative reflectivities of the demineralized fissures were at least 6 times higher than the corresponding sound fissures ( p <0.02). Importantly, this study demonstrated that SS-OCT reflectivity images can be used to predict the depth of fissure demineralization. Despite correctly evaluating the depth, this work showed that the lesion width calculated from SS-OCT ...

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      Mentions: University of Minnesota Robert S. Jones

    21. In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography

      Explore SPIE | Journal Doppler
      In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography

      We developed a three-beam Doppler optical coherence tomography (OCT) system that enables measurement of the velocity vector of moving particles in three-dimensions (3-D). The spatial orientation as well as the magnitude of motion can be determined without prior knowledge of the geometry of motion. The system combines three spectral-domain OCT interferometers whose sample beams are focused at the sample by a common focusing lens at three different angles. This provides three spatially independent velocity components simultaneously from which the velocity vector can be reconstructed. We demonstrate the system in a simple test object (rotating disc), a flow phantom, and for ...

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      Mentions: Christoph K. Hitzenberger Michael Pircher Medical University of Vienna

    22. Announcing BIGGS 2014 Biophotonics and Imaging Graduate Summer School June 15th, 2014 Galway, Ireland

      Explore Optical Coherence Tomography News
      Announcing BIGGS 2014 Biophotonics and Imaging Graduate Summer School June 15th, 2014 Galway, Ireland

      The 5 th Biophotonics and Imaging Graduate Summer School (BIGSS) will be taking place from June 15th-20th, 2014 in Galway, Ireland. BIGSS provides a unique opportunity for students to engage with international experts in the field of biophotonics and optics through week long discussion groups and presentations. For more information click HERE .

      Read Full Article
      Mentions: National University of Ireland, Galway

    23. In-stent neoatherosclerosis 10 years after bare metal stent implantation: ruptured vulnerable plaque by optical coherence tomography

      Explore eurointervention.org Cardiology
      In-stent neoatherosclerosis 10 years after bare metal stent implantation: ruptured vulnerable plaque by optical coherence tomography

      In-stent neoatherosclerosis has recently been described as an important mechanism of late stent failure. A 56-year-old man with a single bare metal stent implantation ten years previously presented with new-onset chest pain. Coronary angiography revealed a right coronary artery with focal in-stent restenosis (Online Figure 1). Optical coherence tomography (OCT) demonstrated the presence of fibroatheroma throughout the entire length of the stent. At one point (panel C), a thin-cap fibroatheroma (TCFA) with plaque rupture is noted (Figure 1, Online Figure 2) - 

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    24. Optovue Launches Next Generation Widefield Enface OCT

      Explore Optical Coherence Tomography News Ophthalmology , Other Business News
      Optovue Launches Next Generation Widefield Enface OCT

      Optovue ( www.optovue.com ), a pioneer in spectral-domain optical coherence tomography (SD-OCT), today announced the worldwide launch and availability of Avanti Widefield Enface OCT. Avanti will make its US debut at the annual American Academy of Ophthalmology (AAO) meeting, November 16-19 in New Orleans. Avanti is a next generation diagnostic device providing an all-in-one solution for posterior and anterior high-speed, high-resolution OCT imaging offering 70,000 A-scans per second, Widefield 3D motion correction and 3 micron digital resolution (sampling). With the next wave of OCT technology innovation in mind, Avanti is designed as a scalable platform to take eye care ...

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      Mentions: Optovue Jay Wei FDA
    25. See all articles

  3. Recent Articles From Around The Web

    1. Differentiating Mild Papilledema and Buried Optic Nerve Head Drusen Using Spectral Domain Optical Coherence Tomography

      Explore Ophthalmology Ophthalmology
      Differentiating Mild Papilledema and Buried Optic Nerve Head Drusen Using Spectral Domain Optical Coherence Tomography

      Purpose To evaluate the clinical utility of spectral domain optical coherence tomography (SD-OCT) in differentiating mild papilledema from buried optic nerve head drusen (ONHD). Design Comparative case series. Participants Sixteen eyes of 9 patients with ultrasound-proven buried ONHD, 12 eyes of 6 patients with less than or equal to Frisén grade 2 papilledema owing to idiopathic intracranial hypertension. Two normal fellow eyes of patients with buried ONHD were included. Methods A raster scan of the optic nerve and analysis of the retinal nerve fiber layer (RNFL) thickness was performed on each eye using SD-OCT. Eight eyes underwent enhanced depth ...

      Read Full Article
      Mentions: University of Miami

    2. Feature Of The Week 12/8/2013: Tuning of Vernier Tuned DBR Lasers for Optical Comb Swept Source OCT

      Explore Optical Coherence Tomography News Tunable Sources
      Feature Of The Week 12/8/2013: Tuning of Vernier Tuned DBR Lasers for Optical Comb Swept Source OCT

      Monolithic Vernier tuned distributed Bragg reflector (VT-DBR) lasers are expected to become one of the most promising sources for optical comb swept source optical coherence tomography (SS-OCT) with reduced sensitivity roll-off due to a long coherence length, potential capability for a very fast A-scan rate, and low cost with monolithic structure. However, mainly four problems inhibited an ideal implementations: 1) frequencies deviate from the targeted values when scanned, 2) large amounts of noise appear associated with abrupt changes in injection currents, 3) optically aliased noise appears due to a long coherence length, and 4) the narrow wavelength coverage of a ...

      Read Full Article
      Mentions: Kohji Ohbayashi Kitasato University Advanced Imaging Company Ltd

    3. Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      Explore Wiley::Home Cardiology , Textbooks
      Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order ...

      Read Full Article

    4. The Structure-Function Relationship between Macular Morphology and Visual Function Analyzed by Optical Coherence Tomography in Retinitis Pigmentosa

      Explore Hindawi Publishing Corporation Ophthalmology
      The Structure-Function Relationship between Macular Morphology and Visual Function Analyzed by Optical Coherence Tomography in Retinitis Pigmentosa

      To evaluate the relationship between macular microstructures and visual function in retinitis pigmentosa (RP). Method. Fourier domain optical coherence tomography (FD-OCT) and Goldmann perimetry were used to examine 100 eyes of 100 RP patients. The preserved photoreceptor outer segment (PROS) length was measured at the horizontal and vertical high definition line scans. The PROS area was calculated from slab image and line scans simultaneously. The visual field area (VFA) was quantified. Each retinal thickness was measured: inner retina (IRT), outer retina (ORT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT). Results. The PROS area values acquired differently were consistent ...

      Read Full Article
      Mentions: Carl Zeiss Meditec Zeiss Cirrus HD-OCT

    5. Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Explore Home - Springer Dermatology , Textbooks
      Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Optical coherence tomography (OCT) is a noninvasive imaging method. Using infrared broadband light sources, images of superficial skin layers can be obtained in vivo and real time. In dermatology, OCT can be used for investigation of skin tumors and inflammatory skin diseases, for quantification of skin changes, and for evaluation of treatment effects

      Read Full Article

    6. Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography

      Explore PLoS ONE Ophthalmology
      Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography

      We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 ...

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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    7. Comparison of Choroidal Thickness in Patients with Diabetes by Spectral-domain Optical Coherence Tomography

      Explore KoreaMed Synapse Ophthalmology
      Comparison of Choroidal Thickness in Patients with Diabetes by Spectral-domain Optical Coherence Tomography

      Purpose To evaluate choroidal thickness in diabetes patients using spectral-domain optical coherence tomography. Methods We examined 203 eyes of 203 diabetic participants and 48 eyes of 48 healthy controls. The choroidal thickness at the foveal lesion was measured by enhanced-depth imaging optical coherence tomography. The participants were grouped according to diabetic retinopathy grade: no diabetic change, mild-to-moderate or severe non-proliferative, or proliferative diabetic retinopathy. The study parameters included history, age, axial length, intraocular pressure, central retinal thickness, fasting glucose, and blood pressure. Results The subfoveal choroidal thickness was thinner in eyes with non-proliferative or proliferative diabetic retinopathy than in normal ...

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    8. Multimodal Imaging in Persistent Placoid Maculopathy

      Explore JAMA Network Ophthalmology
      Multimodal Imaging in Persistent Placoid Maculopathy

      Importance Persistent placoid maculopathy (PPM) is a rare clinical entity with features that superficially resemble acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and macular serpiginous choroidopathy. It is important to differentiate PPM from APMPPE because both conditions may appear similar at presentation. Objective To investigate the short-term and long-term retinal changes in patients with PPM using spectral domain optical coherence tomography (SD-OCT), indocyanine green angiography (ICG-A), fluorescein angiography (FA), and fundus autofluorescence (FAF). Design, Setting, and Participants We performed a retrospective medical record review in 5 patients diagnosed as having PPM at tertiary retinal practices. Main Outcomes and Measures Findings ...

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      Mentions: Northwestern University

    9. Anti-VEGF-refractory Exudative Age-related Macular Degeneration: Differential Response According to Features on Optical Coherence Tomography

      Explore KoreaMed Synapse Ophthalmology
      Anti-VEGF-refractory Exudative Age-related Macular Degeneration: Differential Response According to Features on Optical Coherence Tomography

      Purpose To describe optical coherence tomography (OCT) characteristics of neovascular age-related macular degeneration (AMD) patients refractory to intravitreal anti-vascular endothelial growth factor (VEGF) injections (ranibizumab, bevacizumab) and their responses to alternative anti-VEGF agents or photodynamic therapy (PDT). Methods A retrospective review of 267 neovascular AMD patients treated with intravitreal anti-VEGF injections. Results Twenty patients (7.5%) were refractory to anti-VEGF injections (stationary or increased retinal exudation despite three or more monthly injections). They were grouped into either the extensive intraretinal fluid group (IRF group, 9 patients) or the subretinal fluid only group (SRF group, 11 patients) according to OCT findings ...

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      Mentions: Seoul National University Se Joon Woo Kyu Hyung Park

    10. Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms

      Explore SPIE | Journal Cardiology
      Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms

      Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. Two approaches are followed to evaluate this risk: the analysis of the reflectivity decay along the penetration depth and the textural analysis of a two-dimensional spatial distribution of the aortic wall backscattering. Both techniques require preprocessing stages for the identification of the air–sample interface and for the segmentation ...

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      Mentions: University of Cantabria

    11. Use of 2D images of depth and integrated reflectivity to represent the severity of demineralization in cross-polarization optical coherence tomography

      Explore Wiley Online Library Dentistry
      Use of 2D images of depth and integrated reflectivity to represent the severity of demineralization in cross-polarization optical coherence tomography

      Several studies have demonstrated the potential of cross-polarization optical coherence tomography (CP-OCT) to quantify the severity of early caries lesions (tooth decay) on tooth surfaces. The purpose of this study is to show that 2D images of the lesion depth and the integrated reflectivity can be used to accurately represent the severity of early lesions. Simulated early lesions of varying severity were produced on tooth samples using simulated lesion models. Methods were developed to convert the 3D CP-OCT images of the samples to 2D images of the lesion depth and lesion integrated reflectivity. Calculated lesion depths from OCT were compared ...

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      Mentions: Cynthia L. Darling Daniel S. Fried UCSF

    12. Study finds SD-OCT best correlates with perimetry status

      Explore Healio.com Ophthalmology
      Study finds SD-OCT best correlates with perimetry status

      A study comparing three types of nerve fiber layer measurements and their correlation with visual field sensitivity showed that spectral domain-optical coherence tomography predicts standard automated perimetry status significantly better than scanning laser polarimetry and confocal scanner laser tomography. Goren and colleagues reported in Optometry and Vision Science that none of the tests currently used for assessing function and structure can be relied upon on their own. “Identifying structural features that change concurrently with functional measures could indicate a causal relationship, shedding light on the pathophysiological processes leading to vision loss,” they said. The researchers evaluated data from 400 eyes ...

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      Mentions: National Eye Institute

    13. SD-OCT shows mechanisms, risk factors involved in RPE tears

      Explore Healio.com Ophthalmology
      SD-OCT shows mechanisms, risk factors involved in RPE tears

      VIENNA — High-definition spectral-domain optical coherence tomography analysis helped clarify mechanisms and risk factors of retinal pigment epithelium tears occurring in fibrovascular pigment epithelium detachment, according to one specialist. “Fibrovascular PED develops tears in 10% to 15% of the eyes in a variety of retinal disorders. They tend to grow over time, with significant consequences on vision. As they reach the large diameter of grade 3 and 4, they are difficult to treat,” David Sarraf, MD, said at the Advanced Retinal Therapy meeting. David Sarraf SD-OCT analysis showed that the size of the PED in terms of diameter and height and ...

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    14. Zeiss Meditec hits growth target

      Explore optics.org Other Business News
      Zeiss Meditec hits growth target

      Carl Zeiss Meditec says that despite ongoing market volatility it will continue to spend heavily on research and development activity, in a bid to ensure that it stays ahead in an increasingly competitive market. The Germany-headquartered company, which specializes in photonics-based healthcare technologies, made the comments as it posted a 5 per cent increase in annual revenues in its latest financial year. Sales of €906.4 million were near the upper end of the firm’s earlier predicted range, and improved margins delivered earnings before deductions for interest and tax of €133.9 million, up from €122.9 million last ...

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      Mentions: Carl Zeiss Meditec Ludwin Monz

    15. Optical Coherence Tomography for Oral Mucosal Lesions – A Review Article

      Explore jamdsr.com Otolaryngology
      Optical Coherence Tomography for Oral Mucosal Lesions – A Review Article

      Optical coherence tomography (OCT) is used to produce the cross sectional images of tissues. It is a non-invasive technique. It was first introduced by Huang and co-workers in 1991. It can be used for imaging and diagnosing epithelial and subepithelial dysplastic changes within the oral mucosal tissues and in the detection of early oral cancer. Optical coherence tomography produces higher resolution for imaging the epithelium and lamina propria within the normal and dysplastic oral mucosal tissues. Optical coherence tomography technique utilizes near infrared light which allows it to penetrate into the scattering medium and produces submicrometer resolution. OCT can also ...

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    Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M Motion artifact and speckle noise reduction in polarization sensitive optical coherence tomography by retinal tracking Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research OCT Lines up for Dermatology Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects In vivo pump-probe optical coherence tomography imaging in Xenopus laevis Optical coherence tomography 2014 Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish Comparison of longitudinal geometric measurement in human coronary arteries between frequency-domain optical coherence tomography and intravascular ultrasound

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