1. Feature Of The Week Section is on Vacation until September

    The Feature of the Week Section is on summary vacation till September due to large fraction of OCT News subscribers being on a holiday schedule.
  2. Recent Articles From Around The Web

    1. Anterior segment optical coherence tomography in acute anterior uveitis

      Anterior segment optical coherence tomography in acute anterior uveitis

      Purpose: To analyze the corneal thickness and anterior chamber (AC) angle using anterior segment optical coherence tomography (AS-OCT) in patients with acute anterior uveitis (AAU). Methods: Twenty two patients (24 eyes) were included. All patients underwent complete ophthalmological examination, applanation tonometry and AS-OCT at diagnosis and fifteen days after treatment. Results: Average corneal thickness before treatment was 564.2 ± 44.2 µm, 580.0 ± 44.3 µm and 580.1 ± 2.9 µm, respectively in central, pericentral and paracentral cornea. Fifteen days after treatment a significant decrease of corneal thickness was observed, with 529.5 ± 33.1 µm (p=0 ...

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    2. Truncated-correlation photothermal coherence tomography for deep subsurface analysis

      Truncated-correlation photothermal coherence tomography for deep subsurface analysis

      Photothermal diffusion-wave imaging is a promising technique for the analysis of a range of media. However, traditional diffusion-wave techniques are limited by the physics of parabolic diffusion and can only produce depth-integrated planar images. Here, we report a depth-resolved photothermal imaging modality, henceforth termed truncated-correlation photothermal coherence tomography (TC-PCT). This enables three-dimensional visualization of subsurface features, which is not possible with known optical or photothermal imaging techniques. Examples include imaging of solids with intricate subsurface structures and discontinuities, such as holes in steel, burn depth profiles in tissues, and the structure of bone. It is compatible with regulations concerning maximum ...

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    3. EFFECT OF RANIBIZUMAB ON HIGH-SPEED INDOCYANINE GREEN ANGIOGRAPHY AND MINIMUM INTENSITY PROJECTION OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      EFFECT OF RANIBIZUMAB ON HIGH-SPEED INDOCYANINE GREEN ANGIOGRAPHY AND MINIMUM INTENSITY PROJECTION OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

      Purpose: The purpose of this 1-year prospective study was to investigate how induction/pro re nata ranibizumab intravitreal treatment of eyes with neovascular age-related macular degeneration affects the anatomy of choroidal neovascularization (CNV) and the overlying outer retinal tissue. Methods: High-speed indocyanine green (HS-ICG) angiography measurements provided quantification of the CNV size in 60 patients followed for 1 year. Minimum intensity projection optical coherence tomography (MinIP OCT), a novel algorithm assessing minimum optical intensity between the internal limiting membrane and retinal pigment epithelium, measured the area of outer retinal disruption overlying the CNV. Fluorescein angiography was also assessed to evaluate ...

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    4. Handheld Micromanipulator for Robot-Assisted Microsurgery (Thesis)

      Handheld Micromanipulator for Robot-Assisted Microsurgery (Thesis)

      Robot-assisted surgery has been increasingly adopted in a wide variety of surgical applications because it offers fine manipulation with high precision and dexterity. Despite the commercial success of robotic platforms, practical use in microsurgery is still challenging due to a considerable level of accuracy required at sub-millimeter scales. Limited visualization and constrained accessibility also hinder operation under operating microscopes. Furthermore, lack of tactile feedback may lead to substantial and even irrecoverable injury. To address these issues in microsurgery, a handheld micromanipulator, Micron, has been introduced as an alternative to conventional robotic platforms. It allows surgeons to directly maneuver surgical tools ...

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    5. MACULAR AND PERIPAPILLARY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHANGES IN SICKLE CELL RETINOPATHY

      MACULAR AND PERIPAPILLARY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHANGES IN SICKLE CELL RETINOPATHY

      Purpose: To assess peripapillary retinal nerve fiber layer, macular ganglion cell complex, and total macular thicknesses using spectral domain optical coherence tomography on sickle cell disease patients with and without sickle retinopathy. Method: Nineteen eyes of 11 patients with hemoglobin sickle cell disease, 65 eyes of 36 patients with hemoglobin SS disease, and 48 eyes of 24 healthy subjects underwent spectral domain optical coherence tomography scanning (RTVue). Eyes of patients with sickle cell disease were classified into 3 groups according to posterior segment changes: no retinopathy (n = 64), nonproliferative retinopathy (n = 12), and proliferative retinopathy (n = 8). Results: The central ...

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    6. Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of ...

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    7. Assessment of Coronary Atherosclerosis using Optical Coherence Tomography

      Assessment of Coronary Atherosclerosis using Optical Coherence Tomography

      Optical coherence tomography (OCT) is a catheter-based imaging system that uses near-infrared light to produce cross-sectional images of the coronary arteries. With its extraordinarily high resolution (10-20 μ m), OCT allows clinicians to observe various morphological features of coronary atherosclerosis in vivo . For example, intimal thickening presents as homogeneous, signal-rich regions on OCT, while fibroatheroma with a lipid-rich necrotic core is characterized by the presence of signal-poor regions with a diffuse border. Furthermore, plaque rupture is detected in 50〜70% of culprit lesions of acute coronary syndrome (ACS), and plaque erosion develops over areas of intimal thickening and/or thick-cap fibroatheroma ...

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    8. Two-Level Optical Coherence Tomography Scheme for Suppressing Spectral Saturation Artifacts

      Two-Level Optical Coherence Tomography Scheme for Suppressing Spectral Saturation Artifacts

      We demonstrate a novel method for reducing saturation artifacts in spectral-domain optical coherence tomography (SD-OCT) systems. This method is based on a two-level SD-OCT system with a dual-line charge-coupled device (CCD) camera. We compensate the saturated signal detected by the first line using the unsaturated signal detected by the second line. The Fourier transform of the compensated spectrum shows effective suppression of saturation artifacts. This method was also successfully performed on phantom material and skin on a human finger. Our method causes neither back-scattering power loss nor signal-to-noise ratio (SNR) degradation. The only difference between the traditional system and our ...

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    9. Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      ingenol mebutate gel has been approved lately for the topical treatment of actinic keratoses (AK). Modern imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) have been shown useful for the non-invasive diagnostics of non-melanoma skin cancer 1-6 . Both techniques differ in optical resolution and penetration depth.

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      Mentions: Tanja Maier
    10. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Purpose: Evaluation of bleb morphology using anterior segment optical coherence tomography (OCT) can offer important information regarding bleb function after glaucoma surgery. However, analysis of tissue properties, such as scar fibrosis of blebs, is difficult with conventional OCT. The birefringence of the blebs as susceptible measure of fibrosis scar was evaluated using polarization-sensitive OCT (PS-OCT) and its relation with bleb function was assessed. Methods: One hundred and fifty-three blebs of 122 patients that had undergone trabeculectomy or an Ex-Press tube shunt were examined. Also, in 14 blebs of 12 patients, consecutive measurements were performed for 2 months after surgery. The ...

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    11. A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      Background High-definition optical coherence tomography scanners have recently been developed. Objectives To assess the diagnostic performance of HD-OCT in the differentiation of benign melanocytic skin lesions (MSL) and cutaneous melanoma (CM). Methods Patients with MSL were assessed by HD-OCT. All diagnoses were histopathologically confirmed. One blinded observer evaluated both slice and en-face HD-OCT images and diagnosed MLS on the basis of an algorithm adopted from reflectance confocal microscopy, recent HD-OCT reports, and conventional OCT. Results A total of 93 MSL were studied comprising 66 benign MSL and 27 CM. The sensitivity of HD-OCT was 74.1% [95% confidence interval (CI ...

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    12. SPIE Launches Neurophotonics Journal With Special Section On BRAIN Initiative

      SPIE Launches Neurophotonics Journal With Special Section On BRAIN Initiative

      The new peer-reviewed journal Neurophotonics, published by SPIE, the international society for optics and photonics, will facilitate further collaboration on technological advances in optogenetics, photoacoustics, spectroscopy, and more. This will have significant medical and cognitive applications, and contribute to a comprehensive understanding of the brain. The inaugural issue includes a special section on the the U.S. BRAIN Initiative. The advanced optical methods and applications for imaging and manipulation of the brain that are driving a revolution in the neurosciences were the inspiration behind Neurophotonics, a new peer-reviewed journal published by SPIE, the international society for optics and photonics. The ...

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    13. Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures

      Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures

      We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach is based on spectral encoding of spatial frequency. Information about the spatial structure is directly translated from the Fourier domain to the image domain as different wavelengths, without compromising the accuracy. Axial spatial period profiles of the structure are reconstructed for any volume of interest within the 3D OCT image with nanoscale sensitivity. An example of application of the nanoscale OCT to probe the internal structure of ...

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    14. Achromatic registration of quadrature components of the optical spectrum in spectral domain opticalcoherence tomography

      Achromatic registration of quadrature components of the optical spectrum in spectral domain opticalcoherence tomography

      We have thoroughly investigated the method of simultaneous reception of spectral components with the achromatised quadrature phase shift between two portions of a reference wave, designed for the effective suppression of the 'mirror' artefact in the resulting image obtained by means of spectral domain optical coherence tomography (SD OCT). We have developed and experimentally tested a phase-shifting element consisting of a beam divider, which splits the reference optical beam into the two beams, and of delay lines being individual for each beam, which create a mutual phase difference of π/2 in the double pass of the reference beam. The phase ...

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    15. Biomedical applications of holographic microspectroscopy

      Biomedical applications of holographic microspectroscopy

      The identification and quantification of specific molecules are crucial for studying the pathophysiology of cells, tissues, and organs as well as diagnosis and treatment of diseases. Recent advances in holographic microspectroscopy, based on quantitative phase imaging or optical coherence tomography techniques, show promise for label-free noninvasive optical detection and quantification of specific molecules in living cells and tissues (e.g., hemoglobin protein). To provide important insight into the potential employment of holographic spectroscopy techniques in biological research and for related practical applications, we review the principles of holographic microspectroscopy techniques and highlight recent studies.

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  2. Organizations in the News

    1. (4 articles) Harvard University
    2. (4 articles) Massachusetts General Hospital
    3. (3 articles) National Institutes of Health
    4. (2 articles) Medical University of Vienna
    5. (2 articles) Korea Advanced Institute of Science and Technology
    6. (2 articles) Chang Gung University
    7. (2 articles) Erasmus University
    8. (2 articles) Cleveland Clinic
    9. (1 articles) National University of Ireland, Galway
    10. (1 articles) FDA
  3. People in the News

    1. (2 articles) David A. Boas
    2. (2 articles) Marcus P. Raele
    3. (2 articles) Meng-Tsan Tsai
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    5. (2 articles) Tanja Maier
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    13. (1 articles) Nathan D. Shemonski
    14. (1 articles) Nicolas Foin
    15. (1 articles) Ursula Schmidt-Erfurth
  4. OCT Companies in the News

    1. (3 articles) Optovue
    2. (2 articles) St. Jude Medical
    3. (2 articles) Carl Zeiss Meditec
    4. (1 articles) AGFA Healthcare
    5. (1 articles) Heidelberg Engineering
    6. (1 articles) Axsun Technologies
    7. (1 articles) Volcano Corporation
  5. OCT Products in the News

    1. (3 articles) Optovue RTVue-100
    2. (1 articles) Zeiss Cirrus HD-OCT
    3. (1 articles) Heidelberg Spectralis
    4. (1 articles) Zeiss Visante OCT
    5. (1 articles) Zeiss Stratus OCT
  6. Picture Gallery

    Optical coherence tomography today: speed, contrast, and multimodality Terahertz imaging based on optical coherence tomography Fully Integrated High-Speed Intravascular Optical Coherence Tomography/Near-Infrared Fluorescence Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence-Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atherom Stability in computed optical interferometric tomography (Part I): Stability requirements Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer The Prospective Intraoperative and Perioperative Ophthalmic ImagiNg with Optical CoherEncE TomogRaphy (PIONEER) Study: 2-year Results Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn? Optical coherence tomography applied to tests of skin care products in humans – a case study ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance Postdoctoral Research Associate Opening at University of Liverpool Viewing Dentistry in a New Light Versatile Swept Source With Adjustable Coherence Length
  7. Recent Quotes

    1. Neurophotonics provides a highly visible focal point to facilitate and accelerate the rapidly expanding impact of this discipline.
      By David Boas
    2. Tooth enamel is almost completely transparent in the near-infrared. We showed that you could take an OCT image of a lesion and tell how severe it is. Previously the only option was to extract the tooth and cut it open for closer inspection. Dental decay isn't like cancer. You can actually treat it, arrest it and even reverse it. If you spot the lesions early enough, you can treat them with fluoride and re-mineralize them, and you can measure this with OCT. It gives the clinician a way of telling whether the chemical intervention is working.
      By Daniel S. Fried
    3. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions.
      By Yu Chen
    4. That's why these correlations are important, so that in the future we can be confident regarding the relationship of OCT to MRI, and perhaps be able to use OCT as an additional tool more upfront to help in the diagnosis.
      By Laura Balcer
    5. We are excited about the success story of intraoperative OCT in ophthalmology
      By Eva Lankenau
    6. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions...Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord...An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen
    7. An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen
    8. Conventional pulse oximetry measures oxygen saturation using transmitted light.
      By Shau Poh Chong
    9. The broad set of measurements provided by the system, including angiography, oximetry and red blood cell flow rates enables the direct assessment of tissue oxygen metabolism, which is essential for understanding the evolution of oxygen supply and demand in numerous disease models.
      By Shau Poh Chong
    10. We are delighted to be working with Dr Guitera and the Melanoma Institute of Australia. She is one of the top ten world experts in her field. We believe that our VivoSight system is the future of tumour diagnosis and monitoring and we looking forward to reporting the results in due course.
      By Jon Holmes