Optical Coherence Tomography News

Feature Of The Week Section is on Vacation untill September

The Feature of the Week Section is on summary vacation till September due to large fraction of OCT News subscribers being on a holiday schedule.
Featured Articles
1. Michelson Diagnostics to present at Fortbildungswoche, Munich
  
  Explore Optical Coherence Tomography News Jul 21 2014 Dermatology , Other Business News
  
  Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that leading experts in the use of optical technology in dermatology will be presenting the benefits of multi-beam OCT at the 24th Annual Education Week for Practical Dermatology and Venereology, known as Fortbildungswoche, in Munich, Germany, 19-25 July 2014. The conference session on ‘Evidence for OCT diagnostics’ will take place at 12:15-13:15, Forum 9, on Friday 25th July. The presentations include: Optical coherence tomography scientific fundamentals and applications, Dr. Martina Ulrich Optical coherence tomography for basal cell carcinoma, Prof. Dr ...
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  Mentions: Michelson Diagnostics Jon Holmes Michelson Diagnostics Vivosight
2. A Functional Anatomic Defect of the Cystic Fibrosis Airway
  
  Explore Home (thoracic) Jul 21 2014 Pulmonology
  
  Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. Objective: To establish mechanisms linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea, as well as adult swine trachea in the presence of selective anion inhibitors. Methods: We investigated airway functional microanatomy using micro-optical coherence tomography, a new imaging modality that concurrently quantifies multiple functional parameters of airway epithelium in a co-localized fashion. Main Results: Tracheal explants from wild type swine demonstrated a direct link between periciliary liquid (PCL) hydration and mucociliary transport (MCT) rates, a relationship frequently invoked but never experimentally confirmed ...
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  Mentions: Guillermo J. Tearney Johns Hopkins University Massachusetts General Hospital
3. Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions
  
  Explore eurointervention.org Jul 21 2014 Cardiology
  
  Aims: To assess whether a strategy of invasive management without stents in selected acute coronary syndrome (ACS) patients with a large thrombus burden (LTB) might be feasible and safe. Methods and results: We performed a prospective non-randomised observational cohort study of invasive treatment decisions guided by optical coherence tomography (OCT) in selected ACS patients with LTB. Among 852 ACS patients who had undergone invasive coronary angiography, 101 (11.8%) patients with large thrombus burden on initial angiography underwent thrombectomy to restore TIMI 3 flow without stenting. All of these patients then had repeat angiography with OCT (days 0-2 [Group 1 ...
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  Mentions: Francesco Prati
4. Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography
  
  Explore Circulation Jul 21 2014 Cardiology
  
  Background —Recent reports show that plaque erosion can be diagnosed in vivo using optical coherence tomography (OCT) in patients with acute coronary syndromes (ACS). However, quantitative OCT image criteria for computer-aided diagnosis of plaque erosion have not been established. Methods and Results —A total of 42 patients with ACS caused by plaque erosion were included. Plaque erosion was identified according to the previously established OCT criteria. Both optical properties and morphological features of the focal eroded region as well as erosion-adjacent region were analyzed using a custom designed computer algorithm. Non-eroded fibrous plaques remote from the erosion site within the ...
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  Mentions: Brigham and Women’s Hospital Massachusetts Institute of Technology James G. Fujimoto
5. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography
  
  Explore PLoS ONE Jul 21 2014 Ophthalmology
  
  Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
6. Do you know where your fillers go? An ultrastructural investigation of the lips
  
  Explore Medical Journals Publisher Jul 16 2014
  
  Aim: To investigate the exact location and position of hyaluronic acid fillers in the perioral region by ultrasound and optical coherence tomography. Introduction: To date, there are few in vivo investigations in humans on the exact positioning of injectable hyaluronic acid fillers, and severe complications such as hematoma and thromboembolism are rarely addressed. Materials and methods: There were nine female patients investigated in this pilot study. All of them were periorally injected with hyaluronic acid. The exact product, amount, and locations, as well as the injection techniques, were recorded and compared. Before, immediately after, and 18 days after injection, photo ...
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7. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma
  
  Explore Ophthalmology Jul 16 2014 Ophthalmology
  
  Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto David Huang
8. Avinger Enrolls First PAD Patient in VISION Global Clinical Trial
  
  Explore avinger.com Jul 15 2014 Cardiology , Other Business News
  
  Avinger Inc., pioneer of the lumivascular approach for treating vascular disease announced today that Dr. John Pigott of Jobst Vascular Institute, Toledo, OH, enrolled the first patient in VISION. VISION is a global IDE clinical trial, approved by the FDA to evaluate Avinger’s PantherisTM catheter for the treatment of Peripheral Artery Disease (PAD). It is estimated that PAD affects 12 million people in the US alone. The PantherisTM system combines directional atherectomy capabilities with real-time intravascular visualization to remove plaque from blocked arteries. The minimally invasive catheter is designed to remove plaque, while avoiding the disruption of normal arterial ...
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  Mentions: John B. Simpson FDA Avinger
9. Academic Post Doc Position in Biomedical Optics at the Medical University Vienna
  
  Explore Optical Coherence Tomography News Jul 15 2014 Jobs & Studentships
  
  An academic PostDoc position is available from September 1, 2014 in the Biomedical Optics Division, Center for Medical Physics and Biomedical Engineering . Depending on the candidates’ research record the position may be continued as tenure track after the first two to three years. We offer an academic position at an international highly recognized research institute in the field of biomedical imaging with strong interdisciplinary (door to door) collaboration with clinicians as well as biologists. Our research group is developing novel coherent biomedical imaging methods to overcome the conventional resolution limits and to pave the way from pure structural to functional ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna
10. In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe
  
  Explore opticsinfobase.org Jul 15 2014 Probes
  
  We report three-dimensional (3D) imaging of microcirculation within human cavity tissues in vivo using a high-speed swept-source optical coherence tomography (SS-OCT) at 1300 nm with a modified probe interface. Volumetric structural OCT images of the inner tissues of oral and nasal cavities are acquired with a field of view of 2 mm × 2 mm. Two types of disposable and detachable probe attachments are devised and applied to the port of the imaging probe of OCT system, enabling forward and side imaging scans for selective and easy access to specific cavity tissue sites. Blood perfusion is mapped with OCT-based microangiography from ...
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  Mentions: University of Washington Ruikang K. Wang Woo June Choi
11. Use of Optical Coherence Tomography (OCT) to Cross Peripheral Arterial Chronic Total Occlusions
  
  Explore YouTube Jul 14 2014 Cardiology
  
  Published on Jul 14, 2014 In this series of XLPAD webinars, Dr. Ian Cawich presents a novel application of optical coherence tomography (OCT) in the use of crossing infrainguinal chronic total occlusions (CTO). Dr. Cawich has trained physicians worldwide on how to use the Ocelot (Avinger, Redwood City, CA) CTO crossing device, and he displays his expertise in this webinar, highlighting the keys to using this device and answering questions from experienced peripheral interventionists. Recorded July 10, 2014.
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  Mentions: Avinger
12. Post-Doc Job Offer in Clinical Applications of Image Processing at Duke University
  
  Explore Optical Coherence Tomography News Jul 12 2014 Jobs & Studentships
  
  There is an immediate opening at Duke University Biomedical Engineering Department for a Postdoctoral Research Associate interested in interdisciplinary applications of image processing with emphasis on Optical Coherence Tomography (OCT) and adaptive optics. Post-doc will be supervised by Prof. Sina Farsiu in collaboration with Prof. Joseph A. Izatt and other senior professors from Duke University Electrical and Computer Engineering Department, Biomedical Engineering Department and Duke University School of Medicine. Requirement: PhD in EE, BME, or CS. No previous experience in ophthalmic sciences or optical coherence tomography is necessary. The candidate must have a demonstrated strong background in image processing, as ...
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  Mentions: Joseph A. Izatt National Institutes of Health Duke University
13. Extending XNAT towards a Cloud-Based Quality Assessment Platform for Retinal Optical Coherence Tomographies
  
  Explore IEEE Xplore Jul 12 2014
  
  Neuroscienciﬁc research is increasingly based on image analysis methods. Large sets of imaging data are processed using complex image analysis tools. While today magnetic resonance imaging (MRI) is widely used for both functional and anatomical analysis of the human brain, new imaging modalities are beginning to prove their capabilities for neurological research. Among them, optical coherence tomography (OCT) allows for noninvasive visualization of anatomical structures on a micrometer scale. Becoming a standard diagnostic tool in ophthalmology, it is of rising interest for neurological research. Crucial to all data analysis methods is the quality of the input data. The platform presented ...
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14. Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements
  
  Explore Wiley Online Library Jul 12 2014 Ophthalmology
  
  Purpose To investigate grader learning effect and to quantify intergrader reproducibility of Doppler Spectral-Domain Optical Coherence Tomography (SD-OCT) derived retinal blood flow measurements. Methods Fifteen healthy young subjects (mean age 28.44; SD 3 years) underwent Doppler SD-OCT scans of one eye using the circumpapillary double circular scan protocol of the Optovue RTVue by one of two experienced operators. One trained (i.e. having undergone certification) and one novice (i.e. preliminary training comprising five standard practice data sets) individual then graded a standardized set of scans, consisting of 15 data sets (session 1) using custom Doppler Optical Coherence Tomography ...
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  Mentions: University of Toronto Optovue David Huang
15. Fabrication and Characteristics of Ce-Doped Fiber for High-Resolution OCT Source
  
  Explore IEEE Xplore Jul 12 2014 Broadband Sources
  
  The fabrication of Ce-doped ﬁbers (CeDFs) is demonstrated by drawing-tower method employing rod-in-tube technique. The ﬂuorescence spectrum of CeDFs with a 16-μm core exhibited a 160-nm broadband emission with 1.45-μm axial resolution. This CeDF may be functioned as a high-resolution light source for optical coherence tomography applications.
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  Mentions: National Taiwan University Sun Yat-Sen University Sheng-Lung Huang
16. Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography
  
  Explore OMICS Group Jul 12 2014
  
  Optical coherence tomography has emerged as valuable imaging modality in ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT ...
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  Mentions: Vanderbilt University
17. Optical Coherence Tomography: Age estimation of Calliphora vicina pupae in vivo?
  
  Explore Forensic Science International Jul 10 2014 Developmental Biology
  
  Necrophagous blowfly pupae are valuable contributors to the estimation of post-mortem interval, should an accurate age estimate be obtained. At present, this is reliant on a combination of rearing and destructive methods conducted on preserved samples, including morphological observation and gene expression analyses. This study demonstrates the use of optical coherence tomography (OCT) as a tool for in vivo morphological observation and pupal age estimation. Using a Michelson OCT microscope, alive and preserved four and ten-day old Calliphora vicina pupae were scanned in different orientations. Two and three-dimensional images were created. Morphological characteristics such as the brain, mouthparts and legs ...
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18. Quantitative Assessment of Tissue Prolapse on Optical Coherence Tomography and its Relation with Underlying Plaque Morphologies and Clinical Outcome in Patients with Elective Stent Implantation
  
  Explore International Journal of Cardiology Jul 9 2014 Cardiology
  
  Background Tissue prolapse (TP) is sometimes observed after percutaneous coronary intervention (PCI), but its clinical significance remains unclear. We investigated the relationship between TP volume on optical coherence tomography (OCT) after PCI and underlying plaque morphologies, and the impact of TP on clinical outcomes. Methods We investigated 178 native coronary lesions with normal pre-PCI creatine kinase-myocardial band (CK-MB) values (154 lesions with stable angina; 24 with unstable angina). TP was defined as tissue extrusion from stent struts throughout the stented segments. All lesions were divided into tertiles according to TP volume. The differences in plaque morphologies and 9-month clinical outcomes ...
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  Mentions: Tokyo Medical & Dental University Naohiko Kawaguchi Keiichi Hishikari
19. The investigation of acute optic neuritis: a review and proposed protocol
  
  Explore Nature Publishing Group Jul 9 2014 Neurology , Ophthalmology
  
  Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis ...
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  Mentions: University Hospital Zurich University of Sydney VU University Amsterdam
20. Multiwavelength phase unwrapping and aberration correction using depth filtered digital holography
  
  Explore opticsinfobase.org Jul 8 2014
  
  In this Letter, we present a new approach to processing data from a standard spectral domain optical coherence tomography (OCT) system using depth filtered digital holography (DFDH). Intensity-based OCT processing has an axial resolution of the order of a few micrometers. When the phase information is used to obtain optical path length differences, subwavelength accuracy can be achieved, but this limits the resolvable step heights to half of the wavelength of the system. Thus there is a metrology gap between phase- and intensity-based methods. Our concept addresses this metrology gap by combining DFHD with multiwavelength phase unwrapping. Additionally, the measurements ...
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  Mentions: Dresden University of Technology Nils C. Gerhardt Martin R. Hofmann
21. High-resolution images of inner ear could lead to new hearing loss therapies
  
  Explore College of Engineering Jul 8 2014 Otolaryngology
  
  Understanding how hearing works has long been hampered by challenges associated with seeing inside the inner ear, but technology being developed by a team of researchers that includes a biomedical engineer from Texas A&M University is generating some of the most detailed images of the inner ear to date while offering new insight into the mechanics of hearing that could lead to new therapies for hearing loss. Employing a technique that generates high-resolution, three-dimensional images, Brian Applegate, associate professor in the Department of Biomedical Engineering at Texas A&M, and colleagues from Stanford University are mapping the tissues within ...
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  Mentions: Stanford University Texas A&M University Brian E. Applegate
22. Investigating Recurrent Neural Networks for OCT A-scan Based Tissue Analysis
  
  Explore Schattauer GmbH Jul 7 2014
  
  Objectives: Optical Coherence Tomography (OCT) has been proposed as a high resolution image modality to guide transbronchial biopsies. In this study we address the question, whether individual A-scans obtained in needle direction can contribute to the identification of pulmonary nodules. Methods: OCT A-scans from freshly resected human lung tissue specimen were recorded through a customized needle with an embedded optical fiber. Bidirectional Long Short Term Memory networks (BLSTMs) were trained on randomly distributed training and test sets of the acquired A-scans. Patient specific training and different pre-processing steps were evaluated. Results: Classification rates from 67.5% up to 76% were ...
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  Mentions: University of Tübingen Gereon Hüttmann University of Lübeck
23. Morphometric grading of osteoarthritis by optical coherence tomography - An ex vivo study
  
  Explore Wiley Online Library Jul 7 2014
  
  Optical Coherence Tomography (OCT) yields microscopic cross-sectional images of cartilage in real time and at high resolution. As yet, comprehensive grading of degenerative cartilage changes based on OCT has rarely been performed. This study investigated the potential of quantitative OCT using algorithm-based image parameters such as irregularity (OII – Optical Irregularity Index), homogeneity (OHI – Optical Homogeneity Index) and attenuation (OAI – Optical Attenuation Index) in the objective grading of cartilage degeneration. Therefore, OCT was used to image and assess 113 human osteochondral samples obtained from total knee replacements. Processing included the analysis of OII (by calculation of the standard deviation with regards ...
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  Mentions: RWTH Aachen University Ulrich Marx Robert Schmitt
24. Numerical focusing methods for full field OCT: a comparison based on a common signal model
  
  Explore opticsinfobase.org Jun 29 2014
  
  In this paper a theoretical model of the full field swept source (FF SS) OCT signal is presented based on the angular spectrum wave propagation approach which accounts for the defocus error with imaging depth. It is shown that using the same theoretical model of the signal, numerical defocus correction methods based on a simple forward model (FM) and inverse scattering (IS), the latter being similar to interferometric synthetic aperture microscopy (ISAM), can be derived. Both FM and IS are compared quantitatively with sub-aperture based digital adaptive optics (DAO). FM has the least numerical complexity, and is the fastest in ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
25. See all articles
Recent Articles From Around The Web
1. An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model
  
  Explore jmss.mui.ac.ir Jul 21 2014 Ophthalmology
  
  Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model (GMM) is used for automatic segmentation of three clinically important corneal boundaries on optical coherence tomography (OCT) images. For this purpose, we apply the GMM method in two consequent steps. In the first step, the GMM is applied on the original image to localize the first and the last boundaries. In the next step, gradient response of a ...
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2. Fienup Algorithm With Sparsity Constraints: Application to Frequency-Domain Optical-Coherence Tomography
  
  Explore IEEE Xplore Jul 21 2014
  
  We address the problem of reconstructing a sparse signal from its discrete Fourier transform (DFT) magnitude. We refer to this problem as the sparse phase retrieval (SPR) problem, which finds applications in tomography, digital holography, electron microscopy, etc. We develop a Fienup-type iterative algorithm, which we refer to as the max-K algorithm, to enforce sparsity, and to successively refine the estimate of phase. We show that the max-K algorithm possesses Cauchy convergence properties under certain conditions, that is, the mean-squarederror (MSE) of reconstruction does not increase with iterations. We also formulate the problem of SPR as a feasibility problem, where ...
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  Mentions: Chandra Sekhar Seelamantula
3. Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  Purpose To report a novel spectral-domain optical coherence tomography (SD-OCT) finding in children affected by tilted disc syndrome (TDS), and to correlate it with early visual field defects. Methods Patients between 5 and 17 years old with TDS were enrolled in this study. The diagnosis of TDS was made by stereoscopic fundus photography, when the upper edge of the optic disc protruded anteriorly relative to its lower edge. All eyes were examined with 12 radial SD-OCT B-scans of 12 mm centered on the optic disc; the fundus area encompassing the optic nerve was additionally scanned using several vertical and horizontal ...
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  Mentions: Tokyo Medical & Dental University Kyoko Ohno-Matsui
4. Optical coherence tomography-guided classification of epiretinal membranes
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  To study and classify epiretinal membranes (ERMs) based on spectral domain optical coherence tomography (SD-OCT) findings. One hundred and twelve patients with ERMs were examined clinically and underwent OCT examination. The anatomical structure of the macula and vitreoretinal interface was studied. ERMs were classified in two categories: A, with posterior vitreous detachment (PVD) (91 cases), and B, with the absence of PVD (21 cases). Category A was divided into two subcategories: A1, without contraction of the ERM (37 cases), and A2, with the presence of membrane contraction (54 cases). A2 was further subdivided into A2.1, with retinal folding (15 ...
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5. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study
  
  Explore iovs.org Jul 21 2014 Ophthalmology
  
  Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...
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6. Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial
  
  Explore eurointervention.org Jul 21 2014 Cardiology
  
  Aims: To compare stent strut coverage using optical coherence tomography (OCT) at three-month follow-up between a PLGA-polymer with electro-grafting base layer sirolimus-eluting stent (SES) (BuMA) and a PLA-polymer SES (EXCEL). Methods and results: This prospective, single-centre, non-inferiority randomised BuMA-OCT trial enrolled patients with de novo coronary artery lesions, treated with either the BuMA or the EXCEL stent. The study primary endpoint was OCT-evaluated stent strut coverage at three months. Secondary endpoints were neointimal thickness of stent struts, and incomplete stent apposition evaluated with OCT. A total of 80 patients were randomly assigned to receive the BuMA (n=40) or the ...
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  Mentions: Cardiovascular Research Foundation Gary S. Mintz
7. Inner and outer central retinal findings after surgery for rhegmatogenous retinal detachment using different spectral-domain optical coherence tomography devices
  
  Explore Home - Springer Jul 21 2014 Ophthalmology
  
  Purpose The aim of the study was to analyse macular changes after rhegmatogenous retinal detachment (RRD) repair using spectral-domain optical coherence tomography (SD-OCT). Methods Forty eyes with macula-on and 27 eyes with macula-off RRD underwent scleral buckling or vitrectomy and were postoperatively imaged using 2 SD-OCT devices (Cirrus® HD-OCT, RTVue-100®). Measurement of total and inner macular thickness consisting of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus or retinal nerve fibre layer + ganglion cell layer + inner plexiform layer (RNFL-GCL-IPL) using RTVue was performed. Results of inner macular thickness were compared with image results of 40 healthy controls. Qualitative analysis ...
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  Mentions: Optovue Carl Zeiss Meditec Zeiss Cirrus HD-OCT
8. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma
  
  Explore iovs.org Jul 21 2014 Ophthalmology
  
  Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...
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  Mentions: Optovue RTVue-100 Yonsei University Gong Je Seong
9. An Optical Coherence Tomography-based Analysis of Choroidal Morphologic Features and Choroidal Vascular Diameter in Children and Adults
  
  Explore American Journal of Ophthalmology Jul 21 2014 Ophthalmology
  
  Purpose To analyze choroidal sublayers and vascular diameter in children, and to compare these choroidal features with those of adults. Design Retrospective observational study Methods This study included 96 eyes from 48 healthy children and 54 eyes from 27 healthy adults. The subfoveal choroidal thickness, large choroidal vessel layer thickness, medium choroidal vessel layer-choriocapillaris layer thickness, and large choroidal vessel diameter were estimated. The ratio of thickness of the large choroidal vessel layer to total choroidal thickness was calculated. The association between subfoveal choroidal thickness with large choroidal vessel layer, as well as ratio of thickness of the large choroidal ...
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  Mentions: Sungkyunkwan University Samsung
10. Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study
  
  Explore Nature Publishing Group Jul 21 2014 Ophthalmology
  
  Purpose To compare intraocular lens implantation using a motorized injector vs standard manual injector through a 2.2-mm clear corneal incision. Methods Patients underwent standard phacoemulsification using a 2.2-mm clear corneal incision. Hydrophobic acrylic aspheric intraocular lens (Acrysof SN60WF intraocular lens (IOL)) was inserted using D cartridge with manual monarch injector or autosert motorized injector. IOL safety, final incision size and wound integrity in terms of anterior and posterior wound gape, and descemet’s membrane detachment were compared between the two groups at post-operative day 1 and at 1 month using Anterior Segment Optical Coherence Tomography. Results The study ...
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11. Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy
  
  Explore LWW Online Jul 21 2014 Ophthalmology
  
  Purpose: To evaluate the diagnostic accuracy of glaucoma in different stages, different types of glaucoma, and different ethnic groups using Stratus optical coherence tomography (OCT). Methods: We searched MEDLINE to identify available articles on diagnostic accuracy of glaucoma published between January 2004 and December 2011. A PubMed (National Center for Biotechnology Information) search using medical subject headings and keywords was executed using the following terms: "diagnostic accuracy" or "receiver operator characteristic" or "area under curve" or "AUC" and "Stratus OCT" and "glaucoma." The search was subsequently limited to publications in English. The area under a receiver operator characteristic (AUC) curve ...
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  Mentions: Carl Zeiss Meditec Zeiss Stratus OCT
12. Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis
  
  Explore Home - Springer Jul 21 2014 Cardiology
  
  The occurrence of deteriorated coronary flow associated with distal embolization during percutaneous coronary intervention results in impaired myocardial perfusion and worsens the clinical prognosis. This study aimed to examine the impact of optical coherence tomography (OCT)-determined coronary plaque morphology on the prediction of deteriorated coronary flow after stent implantation in acute as well as stable coronary syndromes (ACS and SAP, respectively). We studied 126 patients who underwent OCT during stenting for ACS ( n = 44) and SAP ( n = 82) with a de novo lesion. Angiographic deteriorated coronary flow was defined as the deterioration of TIMI flow grade after mechanical dilatation ...
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13. Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia
  
  Explore Home | Physiological Reports Jul 21 2014 Ophthalmology
  
  The purpose of this study was to investigate changes in total retinal blood flow (RBF) using Doppler Fourier Domain Optical Coherence Tomography (Doppler FD‐OCT) in response to the manipulation of systemic partial pressure of CO 2 (P ET CO 2 ). Double circular Doppler blood flow scans were captured in nine healthy individuals (mean age ± standard deviation: 27.1 ± 4.1, six males) using the RTVue ™ FD‐OCT (Optovue). P ET CO 2 was manipulated using a custom‐designed computer‐controlled gas blender (RespirAct ™ ) connected to a sequential gas delivery rebreathing circuit. Doppler FD‐OCT measurements were captured at baseline ...
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  Mentions: Optovue David Huang University of Waterloo
14. Light sheet imaging the Airy way
  
  Explore Home: SPIE.org Jul 18 2014 Microscopy
  
  Recent decades have seen an expansion in the breadth of light-based imaging techniques that address problems in biomedicine. Despite perceived limitations in terms of penetration depth and resolution, optical imaging has made significant strides to encroach upon the traditional territory of other modalities, such as electron microscopy and x-ray. At the nanoscale, optical methods exploit light fields in tandem with the properties of fluorescent proteins to answer biological questions in neuroscience and virology that were previously restricted to electron microscopy. At the larger scale, the same methods are making headway to generate biopsies solely with light. A prime example is ...
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  Mentions: University of St. Andrews Kishan Dholakia
15. To Be or not TB?
  
  Explore BJO Online Jul 18 2014 Neurology , Ophthalmology
  
  Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...
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  Mentions: Oregon Health & Science University University of Southern California