1. Feature Of The Week Section is on Vacation untill September

    The Feature of the Week Section is on summary vacation till September due to large fraction of OCT News subscribers being on a holiday schedule.
  2. Recent Articles From Around The Web

    1. An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model

      An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model

      Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model (GMM) is used for automatic segmentation of three clinically important corneal boundaries on optical coherence tomography (OCT) images. For this purpose, we apply the GMM method in two consequent steps. In the first step, the GMM is applied on the original image to localize the first and the last boundaries. In the next step, gradient response of a ...

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    2. Fienup Algorithm With Sparsity Constraints: Application to Frequency-Domain Optical-Coherence Tomography

      Fienup Algorithm With Sparsity Constraints: Application to Frequency-Domain Optical-Coherence Tomography

      We address the problem of reconstructing a sparse signal from its discrete Fourier transform (DFT) magnitude. We refer to this problem as the sparse phase retrieval (SPR) problem, which finds applications in tomography, digital holography, electron microscopy, etc. We develop a Fienup-type iterative algorithm, which we refer to as the max-K algorithm, to enforce sparsity, and to successively refine the estimate of phase. We show that the max-K algorithm possesses Cauchy convergence properties under certain conditions, that is, the mean-squarederror (MSE) of reconstruction does not increase with iterations. We also formulate the problem of SPR as a feasibility problem, where ...

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    3. Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome

      Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome

      Purpose To report a novel spectral-domain optical coherence tomography (SD-OCT) finding in children affected by tilted disc syndrome (TDS), and to correlate it with early visual field defects. Methods Patients between 5 and 17 years old with TDS were enrolled in this study. The diagnosis of TDS was made by stereoscopic fundus photography, when the upper edge of the optic disc protruded anteriorly relative to its lower edge. All eyes were examined with 12 radial SD-OCT B-scans of 12 mm centered on the optic disc; the fundus area encompassing the optic nerve was additionally scanned using several vertical and horizontal ...

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    4. Optical coherence tomography-guided classification of epiretinal membranes

      Optical coherence tomography-guided classification of epiretinal membranes

      To study and classify epiretinal membranes (ERMs) based on spectral domain optical coherence tomography (SD-OCT) findings. One hundred and twelve patients with ERMs were examined clinically and underwent OCT examination. The anatomical structure of the macula and vitreoretinal interface was studied. ERMs were classified in two categories: A, with posterior vitreous detachment (PVD) (91 cases), and B, with the absence of PVD (21 cases). Category A was divided into two subcategories: A1, without contraction of the ERM (37 cases), and A2, with the presence of membrane contraction (54 cases). A2 was further subdivided into A2.1, with retinal folding (15 ...

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    5. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...

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    6. Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial

      Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial

      Aims: To compare stent strut coverage using optical coherence tomography (OCT) at three-month follow-up between a PLGA-polymer with electro-grafting base layer sirolimus-eluting stent (SES) (BuMA) and a PLA-polymer SES (EXCEL). Methods and results: This prospective, single-centre, non-inferiority randomised BuMA-OCT trial enrolled patients with de novo coronary artery lesions, treated with either the BuMA or the EXCEL stent. The study primary endpoint was OCT-evaluated stent strut coverage at three months. Secondary endpoints were neointimal thickness of stent struts, and incomplete stent apposition evaluated with OCT. A total of 80 patients were randomly assigned to receive the BuMA (n=40) or the ...

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    7. Inner and outer central retinal findings after surgery for rhegmatogenous retinal detachment using different spectral-domain optical coherence tomography devices

      Inner and outer central retinal findings after surgery for rhegmatogenous retinal detachment using different spectral-domain optical coherence tomography devices

      Purpose The aim of the study was to analyse macular changes after rhegmatogenous retinal detachment (RRD) repair using spectral-domain optical coherence tomography (SD-OCT). Methods Forty eyes with macula-on and 27 eyes with macula-off RRD underwent scleral buckling or vitrectomy and were postoperatively imaged using 2 SD-OCT devices (Cirrus® HD-OCT, RTVue-100®). Measurement of total and inner macular thickness consisting of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus or retinal nerve fibre layer + ganglion cell layer + inner plexiform layer (RNFL-GCL-IPL) using RTVue was performed. Results of inner macular thickness were compared with image results of 40 healthy controls. Qualitative analysis ...

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    8. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...

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    9. An Optical Coherence Tomography-based Analysis of Choroidal Morphologic Features and Choroidal Vascular Diameter in Children and Adults

      An Optical Coherence Tomography-based Analysis of Choroidal Morphologic Features and Choroidal Vascular Diameter in Children and Adults

      Purpose To analyze choroidal sublayers and vascular diameter in children, and to compare these choroidal features with those of adults. Design Retrospective observational study Methods This study included 96 eyes from 48 healthy children and 54 eyes from 27 healthy adults. The subfoveal choroidal thickness, large choroidal vessel layer thickness, medium choroidal vessel layer-choriocapillaris layer thickness, and large choroidal vessel diameter were estimated. The ratio of thickness of the large choroidal vessel layer to total choroidal thickness was calculated. The association between subfoveal choroidal thickness with large choroidal vessel layer, as well as ratio of thickness of the large choroidal ...

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    10. Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study

      Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study

      Purpose To compare intraocular lens implantation using a motorized injector vs standard manual injector through a 2.2-mm clear corneal incision. Methods Patients underwent standard phacoemulsification using a 2.2-mm clear corneal incision. Hydrophobic acrylic aspheric intraocular lens (Acrysof SN60WF intraocular lens (IOL)) was inserted using D cartridge with manual monarch injector or autosert motorized injector. IOL safety, final incision size and wound integrity in terms of anterior and posterior wound gape, and descemet’s membrane detachment were compared between the two groups at post-operative day 1 and at 1 month using Anterior Segment Optical Coherence Tomography. Results The study ...

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    11. Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy

      Meta-analysis of Stratus OCT Glaucoma Diagnostic Accuracy

      Purpose: To evaluate the diagnostic accuracy of glaucoma in different stages, different types of glaucoma, and different ethnic groups using Stratus optical coherence tomography (OCT). Methods: We searched MEDLINE to identify available articles on diagnostic accuracy of glaucoma published between January 2004 and December 2011. A PubMed (National Center for Biotechnology Information) search using medical subject headings and keywords was executed using the following terms: "diagnostic accuracy" or "receiver operator characteristic" or "area under curve" or "AUC" and "Stratus OCT" and "glaucoma." The search was subsequently limited to publications in English. The area under a receiver operator characteristic (AUC) curve ...

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    12. Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis

      Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis

      The occurrence of deteriorated coronary flow associated with distal embolization during percutaneous coronary intervention results in impaired myocardial perfusion and worsens the clinical prognosis. This study aimed to examine the impact of optical coherence tomography (OCT)-determined coronary plaque morphology on the prediction of deteriorated coronary flow after stent implantation in acute as well as stable coronary syndromes (ACS and SAP, respectively). We studied 126 patients who underwent OCT during stenting for ACS ( n = 44) and SAP ( n = 82) with a de novo lesion. Angiographic deteriorated coronary flow was defined as the deterioration of TIMI flow grade after mechanical dilatation ...

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    13. Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      Assessment of total retinal blood flow using Doppler Fourier Domain Optical Coherence Tomography during systemic hypercapnia and hypocapnia

      The purpose of this study was to investigate changes in total retinal blood flow (RBF) using Doppler Fourier Domain Optical Coherence Tomography (Doppler FD‐OCT) in response to the manipulation of systemic partial pressure of CO 2 (P ET CO 2 ). Double circular Doppler blood flow scans were captured in nine healthy individuals (mean age ± standard deviation: 27.1 ± 4.1, six males) using the RTVue ™ FD‐OCT (Optovue). P ET CO 2 was manipulated using a custom‐designed computer‐controlled gas blender (RespirAct ™ ) connected to a sequential gas delivery rebreathing circuit. Doppler FD‐OCT measurements were captured at baseline ...

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    14. Light sheet imaging the Airy way

      Light sheet imaging the Airy way

      Recent decades have seen an expansion in the breadth of light-based imaging techniques that address problems in biomedicine. Despite perceived limitations in terms of penetration depth and resolution, optical imaging has made significant strides to encroach upon the traditional territory of other modalities, such as electron microscopy and x-ray. At the nanoscale, optical methods exploit light fields in tandem with the properties of fluorescent proteins to answer biological questions in neuroscience and virology that were previously restricted to electron microscopy. At the larger scale, the same methods are making headway to generate biopsies solely with light. A prime example is ...

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    15. To Be or not TB?

      To Be or not TB?

      Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...

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  2. Organizations in the News

    1. (2 articles) Massachusetts General Hospital
    2. (2 articles) Yonsei University
    3. (2 articles) Harvard University
    4. (2 articles) Oregon Health & Science University
    5. (2 articles) Massachusetts Institute of Technology
    6. (1 articles) Stanford University
    7. (1 articles) Cardiovascular Research Foundation
    8. (1 articles) Korea University
    9. (1 articles) Sungkyunkwan University
    10. (1 articles) Samsung
  3. People in the News

    1. (2 articles) James G. Fujimoto
    2. (1 articles) Aaron D. Aguirre
    3. (1 articles) Milan Sonka
    4. (1 articles) Tsunenari Soeda
    5. (1 articles) Kyoko Ohno-Matsui
    6. (1 articles) Randy H. Kardon
    7. (1 articles) Chen D. Lu
    8. (1 articles) Hille W. Van Dijk
    9. (1 articles) Chandra Sekhar Seelamantula
    10. (1 articles) Jon Holmes
    11. (1 articles) Ik-Kyung Jang
    12. (1 articles) Zhao Wang
    13. (1 articles) K. Bailey Freund
    14. (1 articles) Hang Lee
    15. (1 articles) Michael D. Abràmoff
  4. OCT Companies in the News

    1. (3 articles) Carl Zeiss Meditec
    2. (2 articles) Optovue
    3. (1 articles) Michelson Diagnostics
    4. (1 articles) NinePoint Medical
  5. OCT Products in the News

    1. (3 articles) Optovue RTVue-100
    2. (1 articles) Zeiss Cirrus HD-OCT
    3. (1 articles) Zeiss Stratus OCT
    4. (1 articles) Michelson Diagnostics Vivosight
  6. Picture Gallery

    Michelson Diagnostics to present at Fortbildungswoche, Munich A Functional Anatomic Defect of the Cystic Fibrosis Airway Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography Do you know where your fillers go? An ultrastructural investigation of the lips Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma Avinger Enrolls First PAD Patient in VISION Global Clinical Trial Academic Post Doc Position in Biomedical Optics at the Medical University Vienna In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe Use of Optical Coherence Tomography (OCT) to Cross Peripheral Arterial Chronic Total Occlusions Post-Doc Job Offer in Clinical Applications of Image Processing at Duke University
  7. Recent Quotes

    1. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions.
      By Yu Chen
    2. That's why these correlations are important, so that in the future we can be confident regarding the relationship of OCT to MRI, and perhaps be able to use OCT as an additional tool more upfront to help in the diagnosis.
      By Laura Balcer
    3. We are excited about the success story of intraoperative OCT in ophthalmology
      By Eva Lankenau
    4. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions...Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord...An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen
    5. An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      By Yu Chen
    6. Conventional pulse oximetry measures oxygen saturation using transmitted light.
      By Shau Poh Chong
    7. The broad set of measurements provided by the system, including angiography, oximetry and red blood cell flow rates enables the direct assessment of tissue oxygen metabolism, which is essential for understanding the evolution of oxygen supply and demand in numerous disease models.
      By Shau Poh Chong
    8. We are delighted to be working with Dr Guitera and the Melanoma Institute of Australia. She is one of the top ten world experts in her field. We believe that our VivoSight system is the future of tumour diagnosis and monitoring and we looking forward to reporting the results in due course.
      By Jon Holmes
    9. The unique combination of two established Zeiss gold standards means we can now offer surgeons more comprehensive visualization during surgery, which enables better treatment results.
      By Ludwin Monz
    10. We look forward to collaborating with strong academic partners, such as Ecole Polytechnique & Université de Montréal, to bring innovative optical components to the market place. We are also excited to contribute to strengthening Montréal's position as a technological center in Photonics.
      By Eric Geoffrion