1. Recent Articles From Around The Web

    1. OCT angiography quantitates differences in lesion responses to anti-VEGF therapy

      OCT angiography quantitates differences in lesion responses to anti-VEGF therapy

      Type 1 neovascular lesions are large, mature and resistant to anti-VEGF therapy, whereas type 3 lesions are small capillary tufts that are highly responsive to just one anti-VEGF injection, according to a study presented here. Using OCT angiography, David Sarraf, MD, and colleagues looked at the quantitative and qualitative effects of anti-VEGF therapy in both types of lesions in cases of age-related macular degeneration. “In this particular study, we wanted to look at the microvascular response of these lesions to anti-VEGF therapy and quantitate the reduction in area and density of these lesions,” Sarraf said at the American Ophthalmological Society ...

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      Mentions: Optovue
    2. SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY IMAGE CONTRAST AND BACKGROUND COLOR SETTINGS INFLUENCE IDENTIFICATION OF RETINAL STRUCTURES

      SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY IMAGE CONTRAST AND BACKGROUND COLOR SETTINGS INFLUENCE IDENTIFICATION OF RETINAL STRUCTURES

      Purpose: To evaluate image contrast and color setting on assessment of retinal structures and morphology in spectral-domain optical coherence tomography. Methods: Two hundred and forty-eight Spectralis spectral-domain optical coherence tomography B-scans of 62 patients were analyzed by 4 readers. B-scans were extracted in 4 settings: W + N = white background with black image at normal contrast 9; W + H = white background with black image at maximum contrast 16; B + N = black background with white image at normal contrast 12; B + H = black background with white image at maximum contrast 16. Readers analyzed the images to identify morphologic features. Interreader correlation was ...

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    3. Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment

      Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment

      Background The purpose of this study was to evaluate the extension and traction effects of posterior vitreous detachment (PVD) complicated with retinal tears using spectral domain optical coherence tomography (OCT) and B-scan ultrasonography. Methods Complete ophthalmological examination, B-scan ultrasonography and spectral domain OCT were performed in patients with acute PVD and retinal tears. Vitreous detachment was classified as complete or incomplete, based on extent of posterior pole or peripheral vitreous detachment. Retinal tear location and persistent traction on the retinal flap was evaluated with B-scan ultrasonography and OCT. Categorical data were evaluated with Fisher’s exact test. Statistical significance was ...

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    4. Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia

      Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia

      Purpose To investigate the relationship between vision and foveal maturity, especially in foveal hypoplasia exhibiting severe structural immaturity. Methods This retrospective observational case series included 42 eyes of 23 patients (mean age, 7.0 ± 5.0 years; 9 patients with foveal hypoplasia as an isolated entity and 14 patients with aniridia). A complete ophthalmic examination included measurement of best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), and outer retinal layers, including Henle’s fiber layer (HFL), were measured and analyzed. Results Using SD-OCT images, eyes were classified as having a differentiated ...

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    5. Serial “En Face” Optical Coherence Tomography Imaging Of Slowly Resorbing Subretinal Fluid After Pneumatic Retinopexy

      Serial “En Face” Optical Coherence Tomography Imaging Of Slowly Resorbing Subretinal Fluid After Pneumatic Retinopexy

      Purpose: To describe the use and utility of serial “en face” C-scan optical coherence tomography in following the postoperative subretinal fluid status in a patient after pneumatic retinopexy treatment of a rhegmatogenous retinal detachment. Method: Case study. Results: Serial “en face” optical coherence tomography imaging enhanced postoperative follow-up of persistent subretinal fluid, demonstrating its spontaneous disappearance over time. Conclusion: Previous studies showed that subretinal fluid persists in a large proportion of patients after rhegmatogenous retinal detachment repair (especially in those with a chronic component). “En face” optical coherence tomography imaging is a valuable tool for demonstrating postoperative fluid status and ...

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    6. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

      The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

      Objective: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. Methods: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. Results: We provide a 9-point checklist encompassing aspects deemed relevant when reporting quantitative OCT studies. The areas covered are study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection ...

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    7. Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

      Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

      Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver. Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal ...

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    8. Outer Retinal Layers Alterations in Chronic Central Serous Chorioretinopathy: Spectral Domain-OCT and Fundus Autofluorescence Findings

      Outer Retinal Layers Alterations in Chronic Central Serous Chorioretinopathy: Spectral Domain-OCT and Fundus Autofluorescence Findings

      Purpose To document alteration of the outer retinal layers and fundus autofluorescence (FAF) change in eyes with chronic central serous chorioretinopathy (CSCR). Methods Seventeen eyes of fifteen patients diagnosed with chronic CSCR from January 2014 to March 2015 with at least 6 months of follow-up and no history of surgery were enrolled in this study. Morphologic alterations in the retinal pigment epithelium (RPE), the photoreceptor inner segment/outer segment (IS/OS) junction layer, and the outer retina were evaluated by Spectral domain optical coherence tomography (SD-OCT). The FAF images were obtained via Heidelberg Retina Angiogram using a view mode of ...

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    9. Recanalization of Organized Thrombi Demonstrated by Coronary CT Angiography Compared With OCT

      Recanalization of Organized Thrombi Demonstrated by Coronary CT Angiography Compared With OCT

      Recanalization of organized thrombi (ROT) is a rarely recognized disease histologically characterized by older coronary thrombi forming small lumens or endothelium-lined neovascular channels within thrombus. Optical coherence tomography (OCT) is the method of choice for diagnosis and shows signal-rich, high backscattered septa dividing the lumen into multiple small channels that communicate with each other (1) . Computed tomography angiography (CTA) in the longitudinal and cross-sectional planes may demonstrate the ROT by showing multiple small contrast-filled spaces divided by low-attenuation septa in agreement with the OCT findings (Figures Figure 1 and Figure 2 ). Given its rarity, CTA findings of ROT have not ...

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    10. An All-Fiber-Optic Combined System of Noncontact Photoacoustic Tomography and Optical Coherence Tomography

      An All-Fiber-Optic Combined System of Noncontact Photoacoustic Tomography and Optical Coherence Tomography

      We propose an all-fiber-based dual-modal imaging system that combines noncontact photoacoustic tomography (PAT) and optical coherence tomography (OCT). The PAT remotely measures photoacoustic (PA) signals with a 1550-nm laser on the surface of a sample by utilizing a fiber interferometer as an ultrasound detector. The fiber-based OCT, employing a swept-source laser centered at 1310 nm, shares the sample arm of the PAT system. The fiber-optic probe for the combined system was homemade with a lensed single-mode fiber (SMF) and a large-core multimode fiber (MMF). The compact and robust common probe is capable of obtaining both the PA and the OCT ...

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    11. The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes

      The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes

      Purpose To evaluate the repeatability of retinal layer thickness measurements in normal eyes imaged using spectral domain optical coherence tomography (SD-OCT). Methods Sixty-eight eyes of 34 healthy subjects were enrolled in this study. Imaging was performed 4 times using 9 × 9 mm macular scans with SD-OCT (RS 3000 Advance HD OCT, NIDEK, Gamagori, Japan) at the same visit by an experienced examiner. After automatic retinal segmentation (layering) in 5 layers, the thickness of each layer was calculated. Macular thickness of 9 Early Treatment of Diabetic Retinopathy Study (ETDRS)–like regions was obtained. Repeatability for each of the 9 subfield areas ...

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      Mentions: Nidek
    12. Assessment of Vascular Response after Stent Implantation by Intracoronary Optical Coherence Tomograph

      Assessment of Vascular Response after Stent Implantation by Intracoronary Optical Coherence Tomograph

      Optical coherence tomography (OCT) is a high resolution (10-20 μm) imaging modality that provides microscopic visualization of the coronary artery including vascular response after stent implantation. Compared to conventional intravascular ultrasound, OCT can more clearly identify findings immediately after stent implantation, such as tissue protrusion, stent edge dissection, and incomplete stent strut apposition. Furthermore, OCT allows clinicians to accurately assess the late acquired stent malapposition and strut coverage which could be a surrogate marker for stent thrombosis after drug-eluting stent (DES) implantation. OCT can evaluate not only the extent and amount of neointima but also the tissue characteristics of neointimal ...

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    13. In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography

      In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography

      High-definition optical coherence tomography (HD-OCT) features of basal cell carcinoma (BCC) have recently been defined. We assessed in vivo optical properties (IV-OP) of BCC, by HD-OCT. Moreover their critical values for BCC subtype differentiation were determined. The technique of semi-log plot whereby an exponential function becomes linear has been implemented on HD-OCT signals. The relative attenuation factor ( µ raf ) at different skin layers could be assessed. . IV-OP of superficial BCC with high diagnostic accuracy (DA) and high negative predictive values (NPV) were (i) decreased µ raf in lower part of epidermis and (ii) increased epidermal thickness (E-T). IV-OP of nodular BCC with ...

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    14. Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      Purpose: To propose a classification of retinal astrocytic hamartoma based on spectral domain optical coherence tomography and correlate each class with systemic manifestations of tuberous sclerosis complex. Methods: Retrospective chart review conducted at four international referral medical retina centers. There were 43 consecutive patients with an established diagnosis of tuberous sclerosis complex based on presence of at least 2 major or 1 major and 2 minor features of the diagnostic criteria. Clinical and spectral domain optical coherence tomography features regarding retinal astrocytic hamartoma were documented. Results: The mean patient age at presentation was 16.2 years. The retinal astrocytic hamartoma ...

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    15. Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography

      Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography

      Purpose: To compare the real-time visualization of vitreoretino-choroidal structures using full-depth imaging (FDI) spectral domain optical coherence tomography (SD-OCT) and swept-source (SS)-OCT. Methods: Foveal scans using both FDI SD-OCT (Heidelberg Spectralis) and SS-OCT (Topcon Deep Range Imaging-OCT-1) were obtained in 40 normal eyes, 40 eyes with macular pathologies, and 40 eyes with glaucoma. Full-depth imaging SD-OCT images were obtained by manually enhancing the vitreoretinal interface first and then the choroid while averaging each OCT B-scan 100 times. Swept-source-OCT images were obtained by averaging each B-scan 96 times. After masking and randomly mixing the original OCT images, two independent physicians ...

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    Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography Perimeter Medical Imaging Receives FDA Clearance for OTISTM Optical Tissue Imaging System Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography Medical Marvel: Duke’s GPU-Powered Imaging Wins $150,000 Global Impact Award Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University Optical teardown of a Kindle Paperwhite display by OCT. An Elastic Second Skin SNR of swept SLEDs and swept lasers for OCT Two Imaging Catheters Unite to Better Detect Dangerous Plaques in Arteries NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S. Polarization sensitive optical coherence microscopy for brain imaging OCT Laser Device Allows Visualization of Skin Without Biopsy
  7. Recent Quotes

    1. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    2. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
      By Philip J. Rosenfeld
    3. Our goal with MicroAngio is to provide a flexible tool that can be used in an optimal fashion for a wide range of applications...MicroAngio comes with customized probes and fixtures for small animal retinal, dorsal window chamber and brain imaging. We also provide a suite of algorithms for data analysis essential for angiographic imaging.”
      By Nishant Mohan
    4. In the majority of cases it is clinically and dermoscopically possible to differentiate between AK and BCC, but there are difficult situations, especially in early cases or during topical therapy, where the diagnosis, grading, subtype and/or lesion thickness is unclear...This data published shows that VivoSight OCT is not only able to differentiate between the two diseases by means of epidermal thickness and signal intensity measurements but also able to be used as a non-invasive technique to determine and monitor the treatment. This technology significantly improves the diagnostic methods currently used resulting in better outcomes for patients.
      By Julia Welzel
    5. We are thrilled to announce FDA clearance of our AngioVue System, which will bring the significant benefits of our innovative, non-invasive retinal imaging to patients in the U.S. who suffer from retinal diseases that lead to progressive blindness...Since we first introduced this technology to markets outside the U.S. fourteen months ago, the technology is in daily clinical use at over 525 clinical sites where it provides a more patient-friendly approach to diseases of the retina that lead to progressive blindness.
      By Jay Wei
    6. In the field of OCT imaging and biometry, size, price and operating power are three critical elements to commercialization in mass market applications...Our MRO system is the first version of OCT with the size, cost and operating power profile to address high volume applications in areas such as mobile personal health monitoring and biometric security.
      By Don Bogue
    7. The clinical benefit to the patient and the work flow to clinics have been a major impact to society.
      By Jay Wei
    8. OCT is a big saver of healthcare dollars – the guidance of anti-vascular endothelial growth factor therapy in age-related macular degeneration alone saves billions of dollars per year by avoiding unnecessary injections.
      By David Huang
    9. “Now we’re at a precipice of potentially a new frontier...This technology means that retina doctors are “seeing things we never thought we would see” and “seeing things maybe we don’t even know how to interpret.
      By Peter K. Kaiser
    10. This is a newsworthy application for those working in the ICU..."Infection is an ever-present risk, and an easier way to check for biofilm could see such checks done more often and infection rates lowered, which would be a great outcome.
      By David D. Sampson