1. Recent Articles From Around The Web

    1. Chronic central serous chorioretinopathy imaged by optical coherence tomographic angiography

      Chronic central serous chorioretinopathy imaged by optical coherence tomographic angiography

      Purpose To describe optical coherence tomographic (OCT) angiography findings in chronic central serous chorioretinopathy (CSC), and to characterize their OCT-B-Scans by the mean of Split Spectrum Amplitude Decorrelation Angiography algorithm. Design Evaluation of an imaging technique in a cohort of patients. Methods Fluorescein (FA) and indocyanine green (ICGA) angiography (Heidelberg Spectralis, Heidelberg, Germany), OCT and OCT angiography with the Split Spectrum Amplitude Decorrelation Angiography algorithm (XR Optovue, Freemont, CA, USA) were performed. A qualitative analysis of the whole imaging data was done. Results Twelve eyes of 10 patients were included. Mean visual acuity was 20/30. All eyes presented findings ...

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    2. Enhanced Optical Coherence Vibration Tomography for Subnanoscale-Displacement-Resolution Calibration of Piezoelectric Actuators

      Enhanced Optical Coherence Vibration Tomography for Subnanoscale-Displacement-Resolution Calibration of Piezoelectric Actuators

      We report a sub nanoscale-displacement-resolution optical coherence vibration tomography (SOCVT) system for real-time calibration of piezoelectric actuators. The calibrations of the actuators at nanoscale or microscale displacement ranges were performed by varying the input voltage over the entire range in the ascending and descending directions. The computational and experimental results demonstrated that the developed SOCVT could be used to characterizethe dynamic hysteretic behaviour, nonlinear effect, and impulsive behaviour of piezoelectric actuators. The SOCVT technique is non-contact and non-invasive in nature, making it ideal for real-time and in situ ultra-precision calibration of piezoelectric actuators, which are widely used in active vibration ...

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    3. Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study

      Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study

      Purpose. To characterize the optical coherence tomography (OCT) findings in late-stage Vogt-Koyanagi-Harada (VKH) disease and its correlation with visual function. Methods. The records of patients with late-stage VKH disease (defined as ≥12 months from disease onset) were retrospectively reviewed. The analysis focused on the OCT findings and microperimetry, in addition to the possible correlation between morphology and functional findings. Results. Twenty-nine patients (58 eyes) were included. Mean age at onset was 34.24 ± 10.67 years. The OCT revealed that the outer retina and retinal pigment epithelium (RPE) were mainly affected. These effects included RPE thickening and breakage or disappearance ...

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    4. 2D fractal analysis in layered retinal structures of healthy and diabetic eyes with optical coherence tomography

      2D fractal analysis in layered retinal structures of healthy and diabetic eyes with optical coherence tomography

      Optical coherence tomography (OCT) is usually employed for the measurement of retinal thickness characterizing the structural changes of tissue. However, fractal dimension (FD) could also character the structural changes of tissue. Therefore, fractal dimension changes may provide further information regarding cellular layers and early damage in ocular diseases. We investigated the possibility of OCT in detecting changes in fractal dimension from layered retinal structures. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) or mild diabetic retinopathy (MDR, n = 43 eyes) and normal healthy subjects (Controls, n = 74 eyes). Fractal dimension was calculated using the differentiate ...

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    5. Real-time in vivo micromorphology and histopathology of choroidal osteoma using enhanced depth imaging

      Real-time in vivo micromorphology and histopathology of choroidal osteoma using enhanced depth imaging

      Choroidal osteoma is a usually unilateral benign tumor of the choroid composed of mature bone. Optical coherence tomography (OCT) has been used to image osteoma for several years. With the advent of enhanced depth imaging (EDI) feature of spectral-domain OCT (SD-OCT), better visualization of the morphology of choroidal lesions has been possible. Herein we present a case of choroidal osteoma in a 45-year-old woman, wherein in vivo morphology of the choroidal osteoma had been visualized using EDI technique of SD-OCT before and after performing photodynamic therapy. EDI OCT has proven to be a valuable noninvasive imaging modality, almost comparable to ...

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    6. Spectral domain optical coherence tomography changes following intravitreal dexamethasone implant, Ozurdex ® in patients with uveitic cystoid macular edema

      Spectral domain optical coherence tomography changes following intravitreal dexamethasone implant, Ozurdex ® in patients with uveitic cystoid macular edema

      Purpose: To correlate the structural and functional changes following intravitreal injection of dexamethasone 0.7 mg (Ozurdex ® ) implant in patients with recalcitrant uveitic cystoid macular edema (CME). Materials and Methods: In a prospective, interventional, nonrandomized study, 30 eyes (27 patients) with uveitic CME received Ozurdex ® implant and were followed-up for 24 weeks at periodic intervals to monitor structural alterations seen on spectral domain optical coherence tomography (SD-OCT). The outcome measures included change in central macular thickness (CMT) and best-corrected visual acuity (BCVA) as well as structural alterations seen on OCT such as change in the height of cystoid spaces (CSs ...

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    7. Effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography

      Effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography

      Aim: The aim of the present study was to study the effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography (OCT). Materials and Methods: One hundred and fifty-one subjects were included from the normative study of foveal morphology carried out at our hospital. Subjects underwent comprehensive eye examination and macular scanning using Cirrus high-definition OCT and axial length (AXL) measurement. Macular cube 512 × 128 scan protocol was used for scanning the macula. Automated measurements of the fovea namely foveal diameter, foveal slope (lateral measurements) and foveal depth (axial measurement) were taken. A correction factor for ...

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    8. Optical coherence tomography and autofluorescence findings in chronic phototoxic maculopathy secondary to snow-reflected solar radiation

      Optical coherence tomography and autofluorescence findings in chronic phototoxic maculopathy secondary to snow-reflected solar radiation

      A professional mountain trekker presented with gradual, moderate visual decline in one eye. The subnormal vision could not be explained by the examination of anterior and posterior segment of either eye, which was unremarkable. Optical coherence tomography and autofluorescence imaging revealed subtle defects in the outer retina, which correlated with the extent of visual disturbance. A novel presentation of retinal phototoxicity due to indirect solar radiation reflected from snow in inadequately protected eyes of a chronically exposed subject is reported.

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    9. Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

      Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

      Purpose: To measure the choroidal thickness (CT) after dynamic exercise by using enhanced depth imaging optical coherence tomography (EDI-OCT). Materials and Methods: A total of 19 healthy participants performed 10 min of low-impact, moderate-intensity exercise (i.e., riding a bicycle ergometer) and were examined with EDI-OCT. Each participant was scanned before exercise and afterward at 5 min and 15 min. CT measurement was taken at the fovea and 1000 μ away from the fovea in the nasal, temporal, superior, and inferior regions. Retinal thickness, intraocular pressure, ocular perfusion pressure (OPP), heart rate, and mean blood pressure (mBP) were also measured. Results ...

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      Mentions: Necip Kara
    10. Microscope-integrated optical coherence tomography: A new surgical tool in vitreoretinal surgery

      Microscope-integrated optical coherence tomography: A new surgical tool in vitreoretinal surgery

      Optical coherence tomography (OCT) has revolutionized imaging of ocular structures and various disease conditions. Though it has been used in the clinic for some decades, the OCT has only recently found its way into the operating theater. Early attempts at intraoperative OCT, hand-held and microscope mounted, have already improved our understanding of the surgical pathology and the role it might play in surgical decision-making. The microscope-integrated OCT now allows seamless, high-resolution, real-time imaging of surgical maneuvers from the incision to wound closure. Visualization of instruments and intraoperative tissue manipulation are possible with this in vivo modality and, therefore, help improve ...

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    11. Measurement of ciliary beat frequency using Doppler optical coherence tomography

      Measurement of ciliary beat frequency using Doppler optical coherence tomography

      Background Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic noncontact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. In this work we used D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. Methods Fresh ex vivo samples of rabbit tracheal mucosa were imaged using both D-OCT and phase-contrast microscopy (n = 5). The D-OCT system was designed and built to specification in our lab (1310-nm swept source vertical-cavity surface-emitting laser ...

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    12. Accurate real-time depth control for CP-SSOCT distal sensor based handheld microsurgery tools

      Accurate real-time depth control for CP-SSOCT distal sensor based handheld microsurgery tools

      This paper presents a novel intuitive targeting and tracking scheme that utilizes a common-path swept source optical coherence tomography (CP-SSOCT) distal sensor integrated handheld microsurgical tool. To achieve micron-order precision control, a reliable and accurate OCT distal sensing method is required; simultaneously, a prediction algorithm is necessary to compensate for the system delay associated with the computational, mechanical and electronic latencies. Due to the multi-layered structure of retina, it is necessary to develop effective surface detection methods rather than simple peak detection. To achieve this, a shifted cross-correlation method is applied for surface detection in order to increase robustness and ...

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    13. To see or not to see: An eye opening optical coherence tomography

      To see or not to see: An eye opening optical coherence tomography

      The clinical problem described in this case arose from a few technical misjudgments. As difficult as it is to be a Monday morning Quarter Back or post one-day cricket analysis, this post PCI complication is further magnified when decisions were made to use a BVS without clear visibility and wires that were not clearly separated. Was this complication avoidable remains to be the question? As the number of percutaneous coronary interventions are growing around the world, more outside US currently than in the USA that was in the lead for past 2 decades, one has to wonder whether the devices ...

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    14. Spectral-domain optical coherence tomography analysis of persistent subretinal fluid after scleral buckling surgery for macula-off retinal detachment

      Spectral-domain optical coherence tomography analysis of persistent subretinal fluid after scleral buckling surgery for macula-off retinal detachment

      Purpose To determine the predictive value of markers for persistent subretinal fluid (SRF) absorption and the influence of subfoveal fluid on visual outcome after scleral buckle (SB) surgery for rhegmatogenous retinal detachment (RRD). Patients and methods This was a retrospective, observational study. We reviewed the medical records of 64 eyes of 64 patients who underwent SB surgery for macula-off RRD. Patients underwent clinical examination and spectral-domain optical coherence tomography before surgery, at 1 month and every 3 months postoperatively. The height and width of SRF bleb(s) were measured over time. Results Persistent SRF at 1 month was observed in ...

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    15. Chromatic dispersion effects in ultra-low coherence interferometry

      Chromatic dispersion effects in ultra-low coherence interferometry

      We consider the properties of an interference signal shift from zero-path-difference position in the presence of an uncompensated dispersive layer in one of the interferometer arms. It is experimentally shown that in using an ultra-low coherence light source, the formation of the interference signal is also determined by the group velocity dispersion, which results in a nonlinear dependence of the position of the interference signal on the geometrical thickness of the dispersive layer. The discrepancy in the dispersive layer and compensator refractive indices in the third decimal place is experimentally shown to lead to an interference signal shift that is ...

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  6. Picture Gallery

    Dark-field full-field optical coherence tomography Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the Center for Ophthalmic Optics & Lasers, Oregon Health & Science University Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy St. Jude Medical Announces Launch of the First International Trial to Compare OCT-Guided Stent Implantation to IVUS or Angiography-Guided PCI Optovue Introduces AngioVue OCTA in Glaucoma High-resolution three-dimensional in vivo imaging of mouse oviduct using optical coherence tomography Computational high-resolution optical imaging of the living human retina Optical Coherence Tomography: Technology and Applications Second Edition (Textbook) Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection Chronic central serous chorioretinopathy imaged by optical coherence tomographic angiography Enhanced Optical Coherence Vibration Tomography for Subnanoscale-Displacement-Resolution Calibration of Piezoelectric Actuators
  7. Recent Quotes

    1. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      By Stephen A. Boppart
    2. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      By Stephen A. Boppart
    3. Based on this pivotal research, we believe that VivoSight scans should become the gold standard for non-invasive diagnosis and monitoring of non-melanoma skin cancer...We are now expanding the availability of our new generation VivoSight scanner in Germany and select territories in Europe.
      By Andy Hill
    4. We are delighted to join Leica Microsystems. Together, we believe we can jointly leverage our ophthalmic imaging technologies, address broader research and clinical markets, and more efficiently complete the next steps in integrating OCT imaging capabilities into the operating room.
      By Eric L. Buckland
    5. These acute results from the VISION study have exceeded even my high expectations going into the trial...Never before have we been able to see the arterial wall during atherectomy, nor have I seen these types of results, with this much control over the procedure outcomes and so little adjunctive therapy required to achieve the desired angiographic results, with only 4% of lesions treated receiving placement of a stent. Based on the data we have seen to date, I believe we continue to be on track to meet or exceed our primary safety endpoint once all six-month follow-up data becomes available.
      By John B. Simpson
    6. The ophthalmic optical coherence tomography (OCT) application was one of the key drivers.
      By John Roush
    7. Why it's a big deal is that OCT is the most commonly ordered test in ophthalmology.
      By David Wilson
    8. What's new is ability to use the OCT device to create an angiogram that actually is better than the one you get from injecting the dye.
      By David Wilson
    9. This is a tremendously exciting approach to granting that fosters the innovative thinking and scientific collaboration that are critical for the future of breast cancer research.
      By Judith A. Salerno
    10. OSA is greatly honored to recognize these leaders in the field of optics.
      By Elizabeth Rogan