1. Recent Articles From Around The Web

    1. Air Pollution and Coronary Plaque Vulnerability and Instability: An Optical Coherence Tomography Study

      Air Pollution and Coronary Plaque Vulnerability and Instability: An Optical Coherence Tomography Study

      Objectives: We assessed the relationship between exposure to air pollutants and mechanisms of coronary instability evaluated by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Background: Air pollution is an emerging key player in determining the residual risk of coronary events. However, pathophysiological mechanisms linking air pollution and coronary events have been not adequately investigated. Methods: Patients with ACS undergoing OCT imaging were retrospectively selected. Mechanism of culprit lesion instability was classified as plaque rupture (PR) or intact fibrous cap (IFC) by OCT, and the presence of macrophage infiltrates (MØI) and thin-cap fibroatheroma (TCFA) at the ...

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    2. Mount Sinai Launches First and Only Eye Stroke Service in New York City to Rapidly Diagnose and Treat Blinding Condition

      Mount Sinai Launches First and Only Eye Stroke Service in New York City to Rapidly Diagnose and Treat Blinding Condition

      Mount Sinai Health System has launched the first eye stroke service in New York City to expedite the diagnosis and treatment of patients who arrive at the emergency room with eye stroke—a medical emergency that must be addressed as quickly as possible to prevent irreversible vision loss. Four emergency departments in the Mount Sinai Health System are now the only sites in New York City equipped with advanced high-resolution imaging systems to rapidly detect eye stroke. These, along with new communication and treatment protocols between emergency medicine physicians, ophthalmologists, and the stroke service, allow patients to have an urgent ...

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    3. Sensorless astigmatism correction using a variable cross-cylinder for high lateral resolution optical coherence tomography in a human retina

      Sensorless astigmatism correction using a variable cross-cylinder for high lateral resolution optical coherence tomography in a human retina

      High lateral resolution ( ∼ 5 µ m ∼5µm ) optical coherence tomography (OCT) that employs a variable cross-cylinder (VCC) to compensate for astigmatism is presented for visualizing minute structures of the human retina. The VCC and its sensorless optimization process enable ocular astigmatism correction of up to − 5.0 −5.0 diopter within a few seconds. VCC correction has been proven to increase the signal-to-noise ratio and lateral resolution using a model eye. This process is also validated using the human eye by visualizing the capillary network and human cone mosaic. The proposed method is applicable to existing OCT, making high lateral ...

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    4. Differences in Culprit Lesions Between Pre-menopausal and Postmenopausal Women with Acute Coronary Syndrome: An Optical Coherence Tomography Study

      Differences in Culprit Lesions Between Pre-menopausal and Postmenopausal Women with Acute Coronary Syndrome: An Optical Coherence Tomography Study

      Background Differences in culprit lesion characteristics remain unclear between pre-menopausal and postmenopausal women with acute coronary syndrome (ACS). Optical coherence tomography (OCT) enables high-resolution in-vivo identification of plaques. We investigated potential differences in culprit lesions between pre-menopausal and postmenopausal women with ACS by using OCT. Methods We included 191 ACS patients who had undergone pre-interventional OCT and stratified them into two groups according to their menopausal status: group A (pre-menopausal, n=97) and group B (postmenopausal, n=94). The characteristics of culprit lesions were compared between the two groups. Results Multivessel lesions were more commonly noted on angiography in the ...

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    5. Correlation of axial length and peripapillary retinal nerve fiber layer thickness measured by Cirrus HD optical coherence tomography in myopes

      Correlation of axial length and peripapillary retinal nerve fiber layer thickness measured by Cirrus HD optical coherence tomography in myopes

      Purpose: To evaluate the RNFL thickness by optical coherence tomography ( OCT ) and correlate it with the axial length and refractive error in myopes. Methods: Patients with myopia −1D to −10D attending ophthalmology OPD at a tertiary hospital from October 2013 to April 2015 for evaluation underwent ophthalmic examination including refraction, axial length, and OCT RNFL thickness measurements. The patients were divided into two groups; group A included patients with AL ≤24 mm and group B AL >24 mm. Results: The study included 100 eyes with myopia ranging from −1D to −10D. The mean (±SD) age was 26.87 (±5.93 ...

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    6. Visually guided chick ocular length and structural thickness variations assessed by swept-source optical coherence tomography

      Visually guided chick ocular length and structural thickness variations assessed by swept-source optical coherence tomography

      Chicks are an excellent model for studying myopia. To study the change of the ocular structures in chicks, ultrasound is mostly used. However, it suffers from limited spatial resolution. In this study, we investigated the axial length (AL) and the thickness of different ocular structures in chicks’ eye undergoing visually induced changes using a swept-source optical coherence tomography (SS-OCT) system in vivo . Two groups of chicks wore a translucent plastic goggle (n = 6) over the right eye to induce form-deprivation myopia. Following 12 days of form deprivation, goggles were removed in one group of chicks (n = 3), and they were ...

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    7. Optical Coherence Tomography Angiography Characteristics Serve as Retinal Vein Occlusion Therapeutic Biomarkers for Dexamethasone Intravitreal Implant

      Optical Coherence Tomography Angiography Characteristics Serve as Retinal Vein Occlusion Therapeutic Biomarkers for Dexamethasone Intravitreal Implant

      Background. Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease. Intravitreal dexamethasone implant has been applied to treat macular edema secondary to RVO (RVO-ME). However, the alteration of morphologic features detected with optical coherence tomography angiography (OCTA) has not been fully studied in RVO-ME patients before and after the treatment. Objective. This study is aimed at identifying potential therapeutic targets in RVO with integrative bioinformatic analysis and compares the OCTA characteristics alterations in patients with RVO-ME receiving injection of dexamethasone intravitreal implant. Methods. Bioinformatic analysis was analyzed in GSE101398 dataset from the Gene Expression Omnibus database ...

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    8. Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning

      Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning

      Percutaneous coronary intervention (PCI) of bifurcation lesions poses unique challenges and carries a high risk of adverse events on follow-up, mainly driven by repeat revascularization and stent thrombosis . Several techniques exist to tackle bifurcation lesions. Among those, double kissing (DK) crush has emerged in recent years as a safe and effective approach for complex bifurcations requiring a two-stent strategy. In its most recent iteration, the DK nano-crush, minimal (ideally less than 3 mm) side branch stent protrusion into the main branch is recommended, to reduce the number of layers of stent struts at the ostium. Angiographic guidance of stent placement ...

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    9. Anterior segment optical coherence tomography findings in leukemic iris infiltration

      Anterior segment optical coherence tomography findings in leukemic iris infiltration

      Iris involvement by acute lymphoblastic leukemia is a very rare primary leukemic infiltration. Blurred vision, conjunctival injection, anterior chamber reaction, pseudohypopyon, thickening of the iris stroma, change in iris shape and color are common clinical signs in leukemic iris infiltration. There is no optimal treatment. Radiotherapy, systemic chemotherapy (high-dose of methotrexate and/or high-dose cytarabine), topical and systemic corticosteroids have been reported as treatment modalities. Herein we present anterior segment optical coherence tomography findings in a 21-years-old, male, diffuse B-cell Acute Lymphoblastic Leukemia (ALL) patient who has a leukemic iris infiltration in his left eye that was successfully treated with ...

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    10. Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT

      Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT

      Purpose: To investigate the value of pattern electroretinography (PERG) and photopic negative response (PhNR) in monitoring glaucoma compared to standard clinical tests (standard automated perimetry (SAP) and clinical optic disc assessment) and structural measurements using spectral-domain OCT. Methods: A prospective study included 32 subjects (32 eyes) with ocular hypertension, suspect or early glaucoma monitored for progression with clinical examination, SAP, PERG, PhNR and OCT for at least 4 years. Progression was defined clinically by the documented change of the optic disc and/or significant visual field progression (EyeSuite™ trend analysis). One eye per patient was included in the analysis. Results ...

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    11. Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Purpose: To assess the dimensions of the limbus-sulcus region measured by swept-source optical coherence tomography (SS-OCT) and correlation study in a large healthy population. Setting: Centro Internacional de Oftalmología Avanzada. Design: Cross-sectional study. Methods: The dimensions of the limbus-sulcus region were measured in 625 eyes of 625 subjects in the temporal and nasal quadrants using a SS-OCT. The limbus-sulcus distance (LSD), the posterior iris line-ocular surface to limbus distance (PIOLD) and the angle to sulcus distance (ASD) were measured. These distances were then assessed for correlations with the factors age, sex, refractive error, anterior chamber angle (ACA), ciliary muscle ...

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    12. Digital ocular swept source optical coherence aberrometry

      Digital ocular swept source optical coherence aberrometry

      Ocular aberrometry is an essential technique in vision science and ophthalmology. We demonstrate how a phase-sensitive single mode fiber-based swept source optical coherence tomography (SS-OCT) setup can be employed for quantitative ocular aberrometry with digital adaptive optics (DAO). The system records the volumetric point spread function at the retina in a de-scanning geometry using a guide star pencil beam. Succeeding test-retest repeatability assessment with defocus and astigmatism analysis on a model eye within ± 3 D dynamic range, the feasibility of technique is demonstrated in-vivo at a B-scan rate of >1 kHz in comparison with a commercially available aberrometer.

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    13. New diagnostic and imaging technologies in dermatology

      New diagnostic and imaging technologies in dermatology

      Introduction Diagnosis of dermatological disorders is primarily based on clinical examination in combination with histopathology. However, clinical findings alone may not be sufficient for accurate diagnosis and cutaneous biopsies are being associated with morbidity. Objective The objective of this article is to review the newer technologies along with their applications, limitation and future prospectus. Methodology Comprehensive literature search was performed using electronic online databases “PubMed” and “Google Scholar”. Articles published in English language were considered for the review. Results In order to improve and/or widen the armamentarium in dermatologic disease diagnosis and therapy, newer emerging technologies are being made ...

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    14. A comparison of different methods to calculate the axial length measured by optical biometry

      A comparison of different methods to calculate the axial length measured by optical biometry

      Purpose To compare axial length (AL) measurements in long eyes by two swept-source optical coherence tomography (SS-OCT) biometers, one based on the group refractive index (IOLMaster 700, Zeiss) and the other based on sum of segments (Argos, Movu), and compare these measurements to previously published methods to optimize AL. Setting I.R.C.C.S. - G.B. Bietti Foundation, Rome, Italy Design Prospective case series Methods AL was measured with both optical biometers in myopic patients (AL > 24.00 mm) and compared to the values obtained with Wang-Koch adjustment, polynomial equations for the Holladay 1 and 2 formulas and Cooke ...

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      Mentions: Movu
    15. Retinal Microvascular and Perfusional Disruption in Paediatric COVID-19: A Case-Control Optical Coherence Tomography Angiography Study

      Retinal Microvascular and Perfusional Disruption in Paediatric COVID-19: A Case-Control Optical Coherence Tomography Angiography Study

      Purpose: To investigate the short-term effect of coronavirus 2019 (COVID-19) on the retinal capillary network and choroid in children. Materials and methods: This prospective, cross-sectional, case-control study included 19 recovered COVID-19 paediatric patients and 20 healthy children. Macular thickness, choroidal thickness, vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) values were obtained. Central vessel and perfusion densities were measured at the central 6-mm area, and the values were compared among three subgroups according to location. Results: The mean ages of patients and controls were 12.42 ± 3.3 years and 13.35 ± 1.2 years, respectively. Significant ...

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    Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography Notal Vision Reports Results from First U.S. Home OCT Feasibility Study Glannaventa Receives a NIH SBIR Grant for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. Simultaneous directional full-field OCT using path-length and carrier multiplexing Line-field confocal optical coherence tomography as a tool for three-dimensional in vivo quantification of healthy epidermis: a pilot study 114 nm broadband all-fiber nonlinear polarization rotation mode locked-laser and time-stretch optical coherence tomography What explorations involve the fundamental workings of the inner ear?– Webinar October 6th, 2021 Luneau Technology Group merges with Optovue Air Pollution and Coronary Plaque Vulnerability and Instability: An Optical Coherence Tomography Study Mount Sinai Launches First and Only Eye Stroke Service in New York City to Rapidly Diagnose and Treat Blinding Condition
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu