1. Recent Articles From Around The Web

    1. Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      Optical coherence tomography angiography in age-related macular degeneration: persistence of vascular network in quiescent choroidal neovascularization

      This study was supported by the Werner H. Spross Foundation (Zurich, Switzerland). The ‘Stiftung wissenschaftliche Forschung, Fonds Ophthalmologie, City Hospital Triemli’ received research grants from Novartis Schweiz AG and Bayer Schweiz AG and payments for invited talks or advisory board participations for M.B and S.M. from Allergan, Novartis, Alimera, Bayer, Roche and Clanotech. None of the authors above has any conflict of interest related to this research. This study was presented as an e-poster (POS- 6771) at the 15th EURETINA Congress in Nice, France (17. – 20.09.2015).

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      Mentions: Stephan Michels
    2. An Evaluation of Computational Imaging Techniques for Heterogeneous Inverse Scattering

      An Evaluation of Computational Imaging Techniques for Heterogeneous Inverse Scattering

      Inferring internal scattering parameters for general, heterogeneous materials, remains a challenging inverse problem. Its difficulty arises from the complex way in which scattering materials interact with light, as well as the very high dimensionality of the material space implied by heterogeneity. The recent emergence of diverse computational imaging techniques, together with the widespread availability of computing power, present a renewed opportunity for tackling this problem. We take first steps in this direction, by deriving theoretical results, developing an algorithmic framework, and performing quantitative evaluations for the problem of heterogeneous inverse scattering from simulated measurements of different computational imaging configurations.

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    3. The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      Immunosuppressed transplant recipients have increased risk for the development of basal cell carcinoma skin cancers. While oral vismodegib therapy has been successful in treating locally advanced basal cell tumors, few studies document its use and efficacy in organ transplant patients. In this immunocompromised population, topical imiquimod 5% cream has been shown to be an effective and well-tolerated option for superficial and nodular basal cell carcinomas. To the authors' knowledge, no data documents the use of optical coherence tomography, a noninvasive imaging technique, to monitor progress of such combined therapies on in vivo skin. The authors report the successful treatment of ...

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    4. Adaptive optics full-field optical coherence tomography

      Adaptive optics full-field optical coherence tomography

      We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level. As a consequence, an image-based algorithm was applied for the optimization process by using the FFOCT image intensity as the metric. Aberration corrections were demonstrated with both an USAF resolution ...

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    5. In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical coherence tomography (SD-OCT) was employed for depth-resolved retinal imaging. A custom-designed animal holder equipped with ear bar and bite bar was used to minimize eye movements. Dynamic OCT imaging revealed ...

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      Mentions: Xincheng Yao
    6. Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection: The Stardust Sign

      Granular Hyperreflective Specks By Spectral Domain Optical Coherence Tomography As Signs Of West Nile Virus Infection:  The Stardust Sign

      Purpose: To report the retinal findings and evolution of a visually symptomatic case of West Nile virus meningoencephalitis. Methods: Case report. Main outcome measures include serologic testing for West Nile virus as well as longitudinal funduscopic examination, fluorescein angiography, and spectral domain optical coherence tomography. Results: A 47-year-old diabetic man was referred for ophthalmic evaluation after hospitalization and treatment for West Nile meningoencephalitis. The patient presented with decreased vision and black spots in the right eye. Baseline visual acuity was 20/100 in the right eye and 20/40 in the left. Funduscopic examination and fluorescein angiography revealed multiple outer-retinal ...

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      Mentions: Rui Wang
    7. Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Purpose To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. Methods This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5–18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Results Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had ...

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    8. Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      Heidelberg Engineering Receives FDA Clearance to Market SPECTRALIS® OCT Glaucoma Module Premium Edition

      The Glaucoma Module Premium Edition for SPECTRALIS provides a comprehensive analysis of the optic nerve head, retinal nerve fiber layer, and ganglion cell layer by precisely matching unique scan patterns to the fine anatomic structures relevant in glaucoma diagnostics. By means of a new proprietary technology called the Anatomic Positioning System, the module creates an anatomic map unique to each patient’s eye using two fixed, structural landmarks: the center of the fovea and the center of Bruch’s membrane opening. All subsequent scan protocols are automatically oriented according to each eye’s unique anatomic map, enabling a precise examination ...

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    9. New fingerprinting technology will aid law enforcement

      New fingerprinting technology will aid law enforcement

      The CSIR has unveiled a new-generation fingerprint sensing technology to aid in law enforcement and forensic areas. The device, funded by the Department of Science and Technology, is the first prototype, and the next step will be to reduce its size to a hand-held gadget and prepare it for commercialisation. The system is capable of exploring the internal features of an object. Laser scientist Ann Sigh said optical coherence tomography used light to capture in 3D the finest of details from biological tissue and could be likened to ultrasound but using light. She said it was important to note that ...

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    10. Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

      Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from ...

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    11. Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis (OCTIMS)

      This is a 3-year, pharmacologically non-interventional study to evaluate OCT as an outcome measure in patients with relapsing remitting multiple sclerosis (RRMS). Approximately 350 RRMS patients, either untreated or treated with an approved MS disease-modifying therapy and approximately 70 reference subjects without ophthalmologic or neurologic disease are enrolled. No study medications are provided. Patients on disease-modifying therapy are treated according to the local prescribing information. For each MS patient and each reference subject, the study consists of Screening (up to 1 month), Baseline, and a 36-month longitudinal data collection phase. Eligibility will be confirmed during Screening.

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    12. Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects

      To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions. The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm 2 and 0.270 ± 0.090 mm 2 , respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the ...

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    13. Paws, print, detect, arrest

      Paws, print, detect, arrest

      South African researchers revealed a prototype fingerprint-sensing device at the CSIR in Pretoria yesterday.  The new technology, the first of its kind in Africa, will be linked to police and Home Affairs fingerprint databases. Through the use of lasers it processes fingerprints taken from crime scenes and from people in under three seconds. Researchers are now hard at work to make the device portable. It is currently the size of a big shoebox and can be fitted to a police vehicle. Co-designer Ameeth Sharman said that in the initial design the technology had been geared towards the collection of "live ...

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    14. Axial length measurement failure rates with biometers using swept source optical coherence tomography compared to partial coherence interferometry and optical low-coherence interferometry

      Axial length measurement failure rates with biometers using swept source optical coherence tomography compared to partial coherence interferometry and optical low-coherence interferometry

      Purpose To compare a new swept source optical coherence tomography (SS-OCT) based biometer (OA-2000) with the IOLMaster v5.4 (partial coherence interferometry) and Aladdin (optical low-coherence interferometry) biometers in terms of axial length measurement and failure rate in eyes with cataract. Design Reliability study Methods A total of 377 eyes of 210 patients were scanned with the three biometers in a random order. For each biometer, the number of unobtainable axial length measurements was recorded and grouped as per the type and severity of cataract based on the Lens Opacities Classification System III by the same experienced ophthalmologist. The Bland-Altman ...

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    1. (4 articles) Harvard University
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    Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography Postdoctoral Associate: Biophotonics and Computer Vision Stanford University, Stanford, CA Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation Micro-optical coherence tomography of the mammalian cochlea Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer Automatic classification of atherosclerotic plaques imaged with intravascular OCT Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry Wideband ultrafast fiber laser sources for OCT and metrology Jennifer Barton a Leader in Cancer research, Imaging Honored with 2016 SPIE President’s and Directors’ Awards Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography
  6. Recent Quotes

    1. Bogue said, “time. We believe strongly that our MRO™ sub-dermal fingerprint technology can play a key role in addressing the presentation attack problem by providing an effective deployable solution.
      By Don Bogue
    2. Today, interdisciplinary research in biomedical optics is the standard. “And that was less common 25 years ago. A lot of innovation happens at the boundaries of disciplines. OCT is such a rich combination of disciplines—in optics, mechanical systems, electronics, software, medical devices, clinical medicine. That’s one of the reasons there’s been so much innovation in OCT, and that there’s so much more to come.
      By Eric A. Swanson
    3. We are excited to bring to market groundbreaking technologies that provide valuable new, detailed information about the microvasculature of the eye, in a manner that reduces the burden for both the patient and the clinic staff...DualTrac Motion Correction allows for improved imaging and quicker data collection to further the clinical utility of OCTA technology by accommodating natural eye movement.
      By Jay Wei
    4. I am pleased to see how well the OCT technology has evolved over the past 25 years to help diagnose and treat the most common causes of blindness, age-related macular degeneration, diabetic retinopathy and glaucoma...OCT use continues to grow exponentially in ophthalmology and other medical specialties, including cardiology, dermatology, neurology and gastroenterology.
      By David Huang
    5. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      By Wolfgang Drexler
    6. This gives us a very controlled way of looking at ovarian cancer.
      By Jennifer K. Barton
    7. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      By Jennifer K. Barton
    8. The real advantage of en face OCT is the ability to slice and dice the images throughout their entire depth, from the choroid to the vitreous.
      By Philip J. Rosenfeld
    9. En face OCT imaging became clinically useful with the advent of high-speed, high-density, spectral domain OCT raster-scanning techniques.
      By Philip J. Rosenfeld
    10. Our goal with MicroAngio is to provide a flexible tool that can be used in an optimal fashion for a wide range of applications...MicroAngio comes with customized probes and fixtures for small animal retinal, dorsal window chamber and brain imaging. We also provide a suite of algorithms for data analysis essential for angiographic imaging.”
      By Nishant Mohan