1. Recent Articles From Around The Web

    1. Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature

      Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature

      Purpose: To quantify the abnormal corneal thinning and posterior surface steepening that is observed in keratoconus with an Ectasia Index. Methods: Optical coherence tomography (OCT) was used to image the corneas of normal individuals and patients with varying stages of keratoconus (manifest, subclinical, and forme fruste). Maps of corneal pachymetry and posterior surface mean curvature were generated, and an Ectasia Index was calculated by multiplying Gaussian fits obtained from the two types of maps. Repeated five-fold cross-validation was used to evaluate the ability of the Ectasia Index to differentiate between normal and keratoconic eyes. The classification performance of the Ectasia ...

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    2. Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

      Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

      Purpose: To explore the relationship between serum uric acid (SUA) and retinochoroidal microcirculation in the Chinese population. Methods: This prospective cross-sectional study was conducted among the residents of Guangzhou, southern China. A commercially available optical coherence tomography angiography (OCTA) device was used to obtain the superficial vessel density (SVD) and deep vessel density in the retina and the choriocapillaris flow deficit (CFD) in the macular region. Univariable and multivariable linear regression models were used to assess the association of hyperuricemia and SUA levels with OCTA parameters. Results: A total of 638 participants with normal SUA and 296 participants with hyperuricemia ...

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    3. Age-related assessment of foveal avascular zone and surrounding capillary networks with swept source optical coherence tomography angiography in healthy eyes

      Age-related assessment of foveal avascular zone and surrounding capillary networks with swept source optical coherence tomography angiography in healthy eyes

      Aim To assess the macular capillary networks and foveal avascular zone (FAZ) with swept-source optical coherence tomography angiography in healthy eyes. Methods This cross-sectional, prospective, observational study enrolled 222 eyes of 116 healthy participants with no ocular or systemic disease. SS-OCTA images were captured using the PLEX Elite 9000 (Carl Zeiss Meditec Inc., Dublin, CA, USA) with a 6 × 6 mm pattern centered on the foveal center. Vessel length density (VLD), perfusion density (PD), and FAZ parameters were analyzed using the manufacturer’s automated software. Results A significant negative correlation was observed between age and average VLD in the superficial ...

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      Mentions: UCLA
    4. Precision of attenuation coefficient measurements by optical coherence tomography

      Precision of attenuation coefficient measurements by optical coherence tomography

      Significance: Optical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g., the attenuation coefficient), which provides information regarding the structure and organization of tissue. However, a rigorous and standardized measure of the precision of the OCT-derived optical properties, to date, is missing. Aim: We present a robust theoretical framework, which provides the Cramér -Rao lower bound σμOCT for the precision of OCT-derived optical attenuation coefficients. Approach: Using a maximum likelihood approach and Fisher information, we derive an analytical solution for ...

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    5. Machine learning classification of multiple sclerosis in children using optical coherence tomography

      Machine learning classification of multiple sclerosis in children using optical coherence tomography

      Background: In children, multiple sclerosis (MS) is the ultimate diagnosis in only 1/5 to 1/3 of cases after a first episode of central nervous system (CNS) demyelination. As the visual pathway is frequently affected in MS and other CNS demyelinating disorders (DDs), structural retinal imaging such as optical coherence tomography (OCT) can be used to differentiate MS. Objective: This study aimed to investigate the utility of machine learning (ML) based on OCT features to identify distinct structural retinal features in children with DDs. Methods: This study included 512 eyes from 187 ( n eyes = 374) children with demyelinating diseases ...

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    6. Daily Self-Imaging with Home OCT Viable Among Patients with nAMD

      Daily Self-Imaging with Home OCT Viable Among Patients with nAMD

      New findings suggest daily home optical coherence tomography (OCT) imaging has feasibility among patients with neovascular age-related macular degeneration (nAMD) . The home OCT additionally allowed for detailed graphical and mathematical analyses of retinal fluid volume trajectories, including novel parameters in order to inform clinical decision making. “It demonstrated good agreement with human expert grading for retinal fluid identification and excellent agreement with the in-clinic OCT scans,” wrote study author Jeffrey Heier, MD, Ophthalmic Consultants of Boston. The prospective, observational study aimed to validate the performance of a home OCT system (Notal Vision Home OCT) for daily self-imaging at home and ...

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      Mentions: Notal Vision
    7. Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery

      Duke University Received a 2022 NIH Grant for $719,653 for Intraoperative OCT Guidance of Intraocular Surgery. The principal investigator is Joseph Izatt. Below is a summary of the proposed work. This is a resubmission application for a Bioengineering Research Partnership (BRP) which brings together a highly collaborative and experienced team of engineers and ophthalmic surgeons to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon’s current stereo microscopic view of ocular structures by continuing to integrate optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice ...

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    8. Duke University Receives NIH Grant for OCTA and Glaucoma Progression in the Non-Human Primate

      Duke University Receives NIH Grant for OCTA and Glaucoma Progression in the Non-Human Primate

      Duke University Received a 2022 NIH Grant for $537,613 for OCTA and Glaucoma Progression in the Non-Human Primate . The principal investigator is Nimesh Patel. Below is a summary of the proposed work. Glaucoma is a group of diseases that results in a pathological loss of retinal ganglion cells (RGC) and irreversible vision loss. Increased intraocular pressure (IOP) is a major risk factor for glaucoma, but some individuals with elevated pressures never develop disease, and others with low pressures progress to blindness. Similarly, in the non-human primate experimental glaucoma model, animals with similar IOP profiles are shown to have significant ...

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    9. University of Alabama at Birmingham Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama at Birmingham Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama at Birmingham Received a 2022 NIH Grant for $108,284 for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease. The principal investigator is Yuqiang Bai. Below is a summary of the proposed work. In humans, the precorneal tear film (PCTF) is a thin layer (~3-5 µm) of a complex biological fluid coating the ocular surface, that serves to nourish and protect the ocular surface and provide a smooth refractive optical surface for vision. In dry eye disease, the PCTF becomes thinner, and destabilizes (evaporates ...

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    10. Massachusetts General Hosptial Receives NIH Grant for Intravascular microstructural, chemical and biomechanical characterization of coronary plaques

      Massachusetts General Hosptial Receives NIH Grant for Intravascular microstructural, chemical and biomechanical characterization of coronary plaques

      Massachusetts General Hosptial Received a 2022 NIH Grant for $689,065 for Intravascular microstructural, chemical and biomechanical characterization of coronary plaques. The principal investigator is Nestor Uribe-Patarroyo. Below is a summary of the proposed work. Heart disease is the leading cause of death in the US; the most prevalent type of heart disease is caused by atherosclerosis, the thickening of the vessel wall and creation of atherosclerotic plaque. Intravascular optical coherence tomography (IV-OCT) has enabled the imaging of coronary artery structures with un- precedented detail, and can be used to evaluate the response to percutaneous coronary intervention when treating atherosclerotic ...

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    11. Theia Imaging, LLD Receives NIH Grant for A Widefield, Handheld OCT system for Patients who are Unable to Cooperate

      Theia Imaging, LLD Receives NIH Grant for A Widefield, Handheld OCT system for Patients who are Unable to Cooperate

      Theia Imaging, LLD Received a 2022 NIH Grant for $145,597 for A Widefield, Handheld OCT system for Patients who are Unable to Cooperate . The principal investigator is Christian Viehland. Below is a summary of the proposed work. Optical coherence tomography (OCT) is the standard of care for the diagnosis and monitoring of adult retinal diseases. However, most clinical OCT devices are large tabletop systems that are not suitable for use with infants, young children, and patients that are unable to cooperate (I/YC/UC patients). As these patients cannot communicate about disturbances to their vision, diagnosis of disease in ...

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    12. Massachusetts General Hosptial Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hosptial Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hosptial Received a 2022 NIH Grant for $189,000 for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography. The principal investigator is David Adams. Below is a summary of the proposed work. Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty ...

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    13. Washington University Receives NIH Grant for Expansion Optical Coherence Microscopy (ExOCM)

      Washington University Receives NIH Grant  for Expansion Optical Coherence Microscopy (ExOCM)

      Washington University Received a 2022 NIH Grant for $236,250 for Expansion Optical Coherence Microscopy (ExOCM) . The principal investigator is Chao Zhou. Below is a summary of the proposed work. Inspired by recent advances in expansion microscopy (ExM), we propose to develop a new technology called expansion optical coherence microscopy (ExOCM). Using a standard optical coherence tomography (OCT) or a high-resolution OCM system, we will obtain super-resolution, molecular-specific images of expanded tissue samples. Our recent pilot experiment demonstrated that intrinsic scattering signals from expanded samples can be observed using OCT, demonstrating the feasibility of ExOCM based on intrinsic scattering contrast ...

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    14. Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives a 2022 NIH Grant for $681,670 for Optically guided catheter ablation of atrial fibrillation. The principal investigator is James Lee. Below is a summary of the proposed work. A trial fibrillation (AF) affects approximately 3 million patients and its prevalence is expected to rise as the population ages. Catheter ablation, the preferred treatment strategy for symptomatic patients, creates local regions of tissue necrosis in the atria called lesions that are meant to abolish abnormal electrical activity that causes AF. However, AF recurrence is significant in these patients mostly due to inadequate lesions formed by ...

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    3D-printed fiber-based zeroth- and high-order Bessel beam generator Postdoctoral Research Position Opening in  Intravascular Imaging at University of California, Davis Pairing imaging, AI may improve colon cancer screening, diagnosis 66% of diagnostic biopsies for common skin cancer can be avoided using Michelson Diagnostics' VivoSight OCT laser scanner Senior Scientist Opening at Topcon Healthcare Efficacy of Artificial Intelligence-Assisted Discrimination of Oral Cancerous Lesions from Normal Mucosa Based on the Oral Mucosal Image: A Systematic Review and Meta-Analysis Investigation of craquelure patterns in oil paintings using precise 3D morphological analysis for art authentication Algorithm Scientist Open Position at Optovue OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study Nondestructive in situ monitoring of pea seeds germination using optical coherence tomography Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography
  5. Recent Quotes

    1. “I am inspired by Dr. Sanford Greenberg’s vision to end blindness and humbled to be recognized along with Prof. Jim Fujimoto and Eric Swanson for the development of optical coherence tomography, a very sensitive imaging technology widely used to detect and diagnose eye diseases...At the Casey Eye Institute, we are continuing to work on ending all preventable blindness by advancing diagnostic technologies, broadening community outreach, and providing cutting edge treatments.
      By David Huang
    2. We will develop a novel method for the imaging and assessment of corneal elastic properties that could potentially be used for routine clinical diagnostics of different corneal diseases and treatment.
      By Kirill V. Larin
    3. The Board, founders, and team at SpectraWAVE have been an inspiring group to join. They are talented, experienced, and purpose-driven, which will be key as we move towards the launch of our new photonic imaging technology for coronary artery disease. Our flagship technology will define our clinical impact and growth, and we are working hard to bring that solution to the market to help as many patients as possible with coronary artery disease.
      By Eman Namati
    4. After planning a procedure with angiography alone, we exposed physicians to all the information provided by OCT on the same blockage and were able to demonstrate the significant impact that the information had on our decisions...OCT takes the guesswork out of angiography, offering doctors real-time high-quality granularity and precision when performing PCIs, and helping doctors make real-time decisions in the cath lab.
      By Hiram G. Bezerra
    5. Previous research has seen a thinning of the retina in Alzheimer's patients, but by adding a light-scattering technique to the measurement, we've found that the retinal nerve fiber layer is also rougher and more disordered...Our hope is that we can use this insight to create an easy and cheap screening device that wouldn't only be available at your doctor's office, but at places like your local pharmacy as well
      By Adam Wax
    6. Despite living in the 'digital age,' surgeons must routinely rely on their eyesight and sense of touch to determine if they have removed the entire tumor during breast-conserving surgery...Due to lack of adequate tools, 20 to 30 percent of patients must return for additional surgery, resulting in substantial physical and financial burdens and increased risk of complications.
      By Brendan F. Kennedy
    7. In ophthalmology we have a wealth of eye images—fundus photographs, optical coherence tomography (OCT), etc.—that are fundamental to the diagnosis, monitoring, and treatment of a number of eye diseases, so this field is ideally suited for deep learning applications.
      By Felipe A. Medeiros
    8. We are delighted to have received MHLW approval of the Novasight Hybrid system. Clinical data in the past several years has increasingly demonstrated that intravascular imaging with either IVUS or OCT has significant potential to improve outcomes in the large number of patients being treated with angioplasty and stenting for coronary artery disease. However, there are substantial differences between the images generated by these two technologies. Until now, physicians in Japan have had to choose between IVUS or OCT when performing percutaneous coronary interventions (PCI). We are delighted that Conavi and Japan Lifeline can now begin to offer both of these highly complementary imaging techniques on a single catheter to physicians in Japan.
      By Brian K. Courtney
    9. It is such a huge honor to be recognized with this prestigious industry award for best healthcare product in 2020, and we’d like to thank SPIE and Photonics Media for sponsoring this incredible opportunity...Our team is working hard to provide better options to millions of patients who suffer from middle ear infections. Following our recent 510(k) clearance from the FDA, we cannot wait to see how the TOMi Scope impacts the standard of care for this incredibly common disease.
      By Ryan L. Shelton
    10. We developed an algorithm that can be used to automatically analyze optical coherence tomography (OCT) images of the retina to predict whether a patient is likely to respond to anti-VEGF treatments...This research represents a step toward precision medicine, in which such predictions help clinicians better select first-line therapies for patients based on specific disease conditions.
      By Sina Farsiu